Publication Information

{'id': 'https://openalex.org/W2072261604', 'doi': 'https://doi.org/10.1172/jci17741', 'title': 'Neuronal degeneration and mitochondrial dysfunction', 'display_name': 'Neuronal degeneration and mitochondrial dysfunction', 'publication_year': 2003, 'publication_date': '2003-02-01', 'ids': {'openalex': 'https://openalex.org/W2072261604', 'doi': 'https://doi.org/10.1172/jci17741', 'mag': '2072261604', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/12569152', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/151870'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1172/jci17741', 'pdf_url': 'http://www.jci.org/articles/view/17741/files/pdf', 'source': {'id': 'https://openalex.org/S114430552', 'display_name': 'Journal of Clinical Investigation', 'issn_l': '0021-9738', 'issn': ['0021-9738', '1558-8238'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320279', 'host_organization_name': 'American Society for Clinical Investigation', 'host_organization_lineage': ['https://openalex.org/P4310320279'], 'host_organization_lineage_names': ['American Society for Clinical Investigation'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'review', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'bronze', 'oa_url': 'http://www.jci.org/articles/view/17741/files/pdf', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5108554998', 'display_name': 'Eric A. Schon', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I78577930', 'display_name': 'Columbia University', 'ror': 'https://ror.org/00hj8s172', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I78577930']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Eric A. Schon', 'raw_affiliation_strings': ['Department of Neurology, Columbia University, New York, New York 10032, USA.'], 'affiliations': [{'raw_affiliation_string': 'Department of Neurology, Columbia University, New York, New York 10032, USA.', 'institution_ids': ['https://openalex.org/I78577930']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5068204379', 'display_name': 'Giovanni Manfredi', 'orcid': 'https://orcid.org/0000-0003-3893-1348'}, 'institutions': [{'id': 'https://openalex.org/I205783295', 'display_name': 'Cornell University', 'ror': 'https://ror.org/05bnh6r87', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I205783295']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Giovanni Manfredi', 'raw_affiliation_strings': ['Department of Neurology and Neuroscience, Weill Medical College of Cornell University, New York, New York, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Neurology and Neuroscience, Weill Medical College of Cornell University, New York, New York, USA', 'institution_ids': ['https://openalex.org/I205783295']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 2, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 5200, 'currency': 'USD', 'value_usd': 5200, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 2.522, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 325, 'citation_normalized_percentile': {'value': 0.999693, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 98, 'max': 99}, 'biblio': {'volume': '111', 'issue': '3', 'first_page': '303', 'last_page': '312'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10301', 'display_name': 'Mitochondrial Function and Pathology', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10301', 'display_name': 'Mitochondrial Function and Pathology', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11027', 'display_name': 'Metabolism and Genetic Disorders', 'score': 0.9987, 'subfield': {'id': 'https://openalex.org/subfields/1308', 'display_name': 'Clinical Biochemistry'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T12494', 'display_name': 'Alcoholism and Thiamine Deficiency', 'score': 0.9953, 'subfield': {'id': 'https://openalex.org/subfields/2728', 'display_name': 'Neurology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/degeneration', 'display_name': 'Degeneration (medical)', 'score': 0.6751985}, {'id': 'https://openalex.org/keywords/neuronal-degeneration', 'display_name': 'Neuronal Degeneration', 'score': 0.47435796}], 'concepts': [{'id': 'https://openalex.org/C2779354088', 'wikidata': 'https://www.wikidata.org/wiki/Q15467261', 'display_name': 'Degeneration (medical)', 'level': 2, 'score': 0.6751985}, {'id': 'https://openalex.org/C28859421', 'wikidata': 'https://www.wikidata.org/wiki/Q39572', 'display_name': 'Mitochondrion', 'level': 2, 'score': 0.5761978}, {'id': 'https://openalex.org/C2992208609', 'wikidata': 'https://www.wikidata.org/wiki/Q1755122', 'display_name': 'Neuronal degeneration', 'level': 3, 'score': 0.47435796}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.39202905}, {'id': 'https://openalex.org/C169760540', 'wikidata': 'https://www.wikidata.org/wiki/Q207011', 'display_name': 'Neuroscience', 'level': 1, 'score': 0.38707292}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.36137864}, {'id': 'https://openalex.org/C142724271', 'wikidata': 'https://www.wikidata.org/wiki/Q7208', 'display_name': 'Pathology', 'level': 1, 'score': 0.3142283}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.28176695}, {'id': 'https://openalex.org/C2779134260', 'wikidata': 'https://www.wikidata.org/wiki/Q12136', 'display_name': 'Disease', 'level': 2, 'score': 0.13492432}], 'mesh': [{'descriptor_ui': 'D008928', 'descriptor_name': 'Mitochondria', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D009474', 'descriptor_name': 'Neurons', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016923', 'descriptor_name': 'Cell Death', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004272', 'descriptor_name': 'DNA, Mitochondrial', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004272', 'descriptor_name': 'DNA, Mitochondrial', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D004579', 'descriptor_name': 'Electron Transport', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005621', 'descriptor_name': 'Friedreich Ataxia', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005621', 'descriptor_name': 'Friedreich Ataxia', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008928', 'descriptor_name': 'Mitochondria', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008928', 'descriptor_name': 'Mitochondria', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D008954', 'descriptor_name': 'Models, Biological', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008957', 'descriptor_name': 'Models, Genetic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009154', 'descriptor_name': 'Mutation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019636', 'descriptor_name': 'Neurodegenerative Diseases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019636', 'descriptor_name': 'Neurodegenerative Diseases', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D009474', 'descriptor_name': 'Neurons', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1172/jci17741', 'pdf_url': 'http://www.jci.org/articles/view/17741/files/pdf', 'source': {'id': 'https://openalex.org/S114430552', 'display_name': 'Journal of Clinical Investigation', 'issn_l': '0021-9738', 'issn': ['0021-9738', '1558-8238'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320279', 'host_organization_name': 'American Society for Clinical Investigation', 'host_organization_lineage': ['https://openalex.org/P4310320279'], 'host_organization_lineage_names': ['American Society for Clinical Investigation'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc151870', 'pdf_url': 'https://europepmc.org/articles/pmc151870?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC151870', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/12569152', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1172/jci17741', 'pdf_url': 'http://www.jci.org/articles/view/17741/files/pdf', 'source': {'id': 'https://openalex.org/S114430552', 'display_name': 'Journal of Clinical Investigation', 'issn_l': '0021-9738', 'issn': ['0021-9738', '1558-8238'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320279', 'host_organization_name': 'American Society for Clinical Investigation', 'host_organization_lineage': ['https://openalex.org/P4310320279'], 'host_organization_lineage_names': ['American Society for Clinical Investigation'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/7', 'score': 0.61, 'display_name': 'Affordable and clean energy'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 66, 'referenced_works': ['https://openalex.org/W1484379620', 'https://openalex.org/W1503983308', 'https://openalex.org/W1525841471', 'https://openalex.org/W1550247880', 'https://openalex.org/W1565043637', 'https://openalex.org/W1635047156', 'https://openalex.org/W1884791709', 'https://openalex.org/W1968089096', 'https://openalex.org/W1969891257', 'https://openalex.org/W1972771185', 'https://openalex.org/W1973552449', 'https://openalex.org/W1975545676', 'https://openalex.org/W1978328896', 'https://openalex.org/W1982930084', 'https://openalex.org/W1985655958', 'https://openalex.org/W1986956003', 'https://openalex.org/W1989110875', 'https://openalex.org/W2000359426', 'https://openalex.org/W2013910899', 'https://openalex.org/W2014011193', 'https://openalex.org/W2015291802', 'https://openalex.org/W2020775154', 'https://openalex.org/W2025455509', 'https://openalex.org/W2030540514', 'https://openalex.org/W2030848377', 'https://openalex.org/W2031738386', 'https://openalex.org/W2033797888', 'https://openalex.org/W2038697027', 'https://openalex.org/W2038941603', 'https://openalex.org/W2040892857', 'https://openalex.org/W2044088459', 'https://openalex.org/W2046665105', 'https://openalex.org/W2047673408', 'https://openalex.org/W2049873418', 'https://openalex.org/W2051118048', 'https://openalex.org/W2052238208', 'https://openalex.org/W2056174109', 'https://openalex.org/W2056644558', 'https://openalex.org/W2064789293', 'https://openalex.org/W2066461799', 'https://openalex.org/W2068521882', 'https://openalex.org/W2068619217', 'https://openalex.org/W2070479140', 'https://openalex.org/W2075997185', 'https://openalex.org/W2087223515', 'https://openalex.org/W2094655287', 'https://openalex.org/W2097281218', 'https://openalex.org/W2105427387', 'https://openalex.org/W2109291482', 'https://openalex.org/W2111316498', 'https://openalex.org/W2111856493', 'https://openalex.org/W2113055838', 'https://openalex.org/W2121042833', 'https://openalex.org/W2125501179', 'https://openalex.org/W2136012285', 'https://openalex.org/W2141435850', 'https://openalex.org/W2144701362', 'https://openalex.org/W2153353641', 'https://openalex.org/W2153618793', 'https://openalex.org/W2160045590', 'https://openalex.org/W2168176110', 'https://openalex.org/W2170632631', 'https://openalex.org/W2264781775', 'https://openalex.org/W408505', 'https://openalex.org/W4242188225', 'https://openalex.org/W4250595227'], 'related_works': ['https://openalex.org/W4206705789', 'https://openalex.org/W3102175623', 'https://openalex.org/W3011782531', 'https://openalex.org/W286472428', 'https://openalex.org/W2561070738', 'https://openalex.org/W2316746604', 'https://openalex.org/W2313979234', 'https://openalex.org/W2084578496', 'https://openalex.org/W2043421056', 'https://openalex.org/W179580088'], 'abstract_inverted_index': {'Parkinson': [0, 4], 'disease': [1, 5, 8, 12], '(PD);': [2], 'familial': [3, 10], '(FPD);': [6], 'Alzheimer': [7, 11], '(AD);': [9], '(FAD);': [13], 'amyotrophic': [14, 19], 'lateral': [15, 20], 'sclerosis': [16, 21], '(ALS);': [17], 'sporadic': [18], '(SALS);': [22], 'oxidative': [23], 'phosphorylation': [24], '(OXPHOS);': [25], 'reactive': [26], 'oxygen': [27], 'species': [28], '(ROS);': [29], 'mitochondrial': [30, 43, 49, 89], 'DNA': [31, 40], '(mtDNA);': [32], 'ribosomal': [33], 'RNA': [34, 37], '(rRNA);': [35], 'transfer': [36], '(tRNA);': [38], 'nuclear': [39], '(nDNA);': [41], 'inner': [42], 'membrane': [44], '(IMM);': [45], 'intermembrane': [46], 'space': [47], '(IMS);': [48], 'encephalomyopathy': [50], 'with': [51, 60], 'lactic': [52], 'acidosis': [53], 'and': [54], 'strokelike': [55], 'episodes': [56], '(MELAS);': [57], 'myoclonus': [58], 'epilepsy': [59], 'ragged-red': [61, 64], 'fibers': [62], '(MERRF);': [63], 'fiber': [65], '(RRF);': [66], 'Kearns-Sayre': [67], 'syndrome': [68, 84], '(KSS);': [69], 'progressive': [70, 99], 'external': [71], 'ophthalmoplegia': [72], '(PEO);': [73], 'cytochrome': [74], 'c': [75], 'oxidase': [76], '(CCO);': [77], 'Leber': [78], 'hereditary': [79], 'optic': [80], 'neuropathy': [81], '(LHON);': [82], 'Leigh': [83], '(LS);': [85], 'Friedreich': [86], 'ataxia': [87], '(FRDA);': [88], 'superoxide': [90], 'dismutase': [91, 94], '(Mn-SOD);': [92], 'Cu,Zn-superoxide': [93], '(Cu,Zn-SOD);': [95], 'β-amyloid': [96], 'peptide': [97], '(Aβ);': [98], 'supranuclear': [100], 'palsy': [101], '(PSP);': [102], 'terminal': [103], 'deoxynucleotidyl': [104], 'transferase': [105]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2072261604', 'counts_by_year': [{'year': 2024, 'cited_by_count': 3}, {'year': 2023, 'cited_by_count': 6}, {'year': 2022, 'cited_by_count': 5}, {'year': 2021, 'cited_by_count': 8}, {'year': 2020, 'cited_by_count': 15}, {'year': 2019, 'cited_by_count': 12}, {'year': 2018, 'cited_by_count': 16}, {'year': 2017, 'cited_by_count': 26}, {'year': 2016, 'cited_by_count': 12}, {'year': 2015, 'cited_by_count': 18}, {'year': 2014, 'cited_by_count': 13}, {'year': 2013, 'cited_by_count': 15}, {'year': 2012, 'cited_by_count': 17}], 'updated_date': '2024-12-13T18:28:00.896287', 'created_date': '2016-06-24'}