Title: Inhibition of Streptozocin-Induced Insulitis and Diabetes With Lobenzarit in CD-1 Mice
Abstract: When multiple low doses (30 mg/kg body wt) of streptozocin were given to CD-1 mice, diabetes associated with L3T4 T-lymphocyte- and B-lymphocyte-predominant insulitis occurred. Thus, a model of type I (insulin-dependent) diabetes was obtained. To treat these diabetic mice, we administered lobenzarit (CCA), a newly synthesized immunomodulator. CCA (2 or 10 mg/kg body wt) significantly inhibited the progression of diabetes by suppressing the severity and incidence of insulitis. Insulin contents of the pancreas were preserved. The possibility that autoimmune-related diabetes can be treated with CCA warrants further attention.
Publication Year: 1989
Publication Date: 1989-05-01
Language: en
Type: article
Indexed In: ['crossref', 'pubmed']
Access and Citation
Cited By Count: 4
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