Title: 19 Gastric Tumor Development in SMAD3-Deficient Mice Initiates From Forestomach/Glandular Transition Zone Along the Lesser Curvature
Abstract: and, if genetic, to identify the mode of inheritance of FBE.The inheritance models were compared by likelihood ratio tests and Akaike's A Information Criterion.RESULTS: The random environmental and/or a multifactorial components were insufficient to fully explain the familial nature of FBE, but rather there is segregation of a major type transmitted from one generation to the next (p-value < 10-10).An incompletely dominant inheritance model together with a polygenic component fits the data best.For this dominant model, the estimated average penetrance of the dominant allele is 0.1005 (95% CI: 0.0587 to 0.1667) and the average sporadic rate is 0.0012 (95% confidence interval: 0.0004 to 0.0042), corresponding to an average relative risk of 82.53 (95% confidence interval: 28.70 to 237.35), or odds ratio of 91.63 (95% CI: 32.01 to 262.29).CONCLUSIONS: This segregation analysis provides epidemiological evidence in support of one or more rare autosomally inherited dominant susceptibility allele(s) in FBE families, and hence motivates linkage analyses.