Title: MK-801 blocks NMDA receptor-mediated synaptic transmission and long term potentiation in rat hippocampal slices
Abstract: The effect of the anticonvulsant and neuroprotective agent (+)-5-methyl-10,11-dihydro-5H-dibenzo[a,d]cyclo-hepten-5,10-imine maleate (MK-801) has been studied on synaptic events in the CA1 region of rat hippocampal slices. MK-801 blocked selectively the N-methyl-d-aspartate receptor-mediated component of synaptic transmission, which can be recorded in response to single shock stimulation of the Schaffer collateral-commissural pathway in the absence of added Mg2+ to the perfusate. MK-801 also prevented the induction of long term potentiation, which is normally produced in this pathway by high frequency stimulation in the presence of Mg2+.
Publication Year: 1987
Publication Date: 1987-09-01
Language: en
Type: article
Indexed In: ['crossref', 'pubmed']
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Cited By Count: 194
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