Store-operated Calcium Entry in Vascular Endothelial Cells Is Inhibited by cGMP via a Protein Kinase G-dependent Mechanism

Name: Work Video:
Duration: 3 min 30 s
Hiu Yee Kwan; Yü Huang; Xiaoqiang Yao
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3121, 3131, 3172, 3334, 3363, 3467, 3472, 3494, 3513, 3518, 3711, 3758, 3804, 3973, 4045, 4334, 4342, 4351, 4420], 'key': [27, 173, 214, 360, 729, 1230], 'vasodilatory': [28, 215], 'factor.': [29, 216], 'In': [30, 217, 411, 979, 1320, 1381, 1989, 4056, 4306], 'this': [31, 218, 516, 555, 1152, 1210, 1321, 1761, 2037, 2274, 2550, 2571, 2664, 2815, 3107, 3117, 3216, 3705, 3775, 3790, 4057, 4065, 4097], 'study,': [32, 219, 3217, 4058], 'we': [33, 220, 1520, 1727, 2236, 2446, 3054, 3218, 3970, 4059], 'examined': [34, 221, 1430, 1729], 'role': [36, 174, 223, 361, 731, 1176, 1231, 2229, 2538, 2554, 3713], 'cGMP': [38, 118, 126, 157, 163, 225, 305, 313, 344, 350, 726, 741, 862, 885, 1095, 1156, 1178, 1201, 1224, 1677, 1718, 1952, 2198, 2231, 2244, 2257, 2279, 2310, 2338, 2351, 2388, 2411, 2414, 3032, 3035, 3361, 3369, 3412, 3444, 3459, 3625, 3668, 3682, 3915, 4115, 4146, 4346, 4361], 'regulating': [40, 227], 'store-operated': [42, 65, 180, 229, 252, 367, 421, 474, 573, 733, 745, 890, 1189, 1205, 1237, 1289, 1679, 1793, 1847, 2233, 2540, 3322, 3353, 3378, 4118, 4153], 'aortic': [46, 233, 2392, 2860, 3384], 'cells.': [48, 186, 235, 373, 875, 978, 1195, 2249, 2262, 2394, 2862, 4134], 'Cyclopiazonic': [49, 236], 'acid': [50, 237, 383], '(CPA)': [51, 238], 'and': [52, 105, 133, 239, 292, 320, 409, 525, 589, 701, 789, 816, 872, 880, 954, 961, 967, 1179, 1208, 1225, 1256, 1271, 1287, 1358, 1439, 1715, 1738, 1753, 1776, 1787, 2046, 2132, 2140, 2303, 2354, 2833, 2879, 2940, 2952, 3071, 3085, 3098, 3178, 3186, 3221, 3301, 3340, 3370, 3490, 3548, 3627, 3659, 3683, 3689, 3691, 3760, 3769, 3946, 4079, 4110, 4395], 'thapsigargin,': [53, 240, 2449, 3222], 'two': [54, 241, 1522, 2989, 3223, 3928], 'selective': [55, 242, 2451], 'inhibitors': [56, 243, 3225, 3338], 'endoplasmic': [58, 245, 587, 1253, 2454, 2834, 3227], 'reticulum': [59, 246, 588, 1254, 2455, 2835, 3228], 'Ca2+-ATPase,': [60, 247, 3229], 'were': [61, 248, 1355, 1758, 1860, 1870, 1886, 2054, 2081, 2332, 2396, 2405, 2520, 2576, 2679, 2910, 3076, 3093, 3661], 'used': [62, 249, 1521, 1671, 1759, 2334, 2448, 2509, 2851, 3219, 3662], 'induce': [64, 251, 1327], 'entry.': [67, 108, 254, 295, 735, 1681, 2170, 4356], '8-Bromo-cGMP,': [68, 255], 'an': [69, 256, 949, 1199, 1391, 1565, 1697, 1720, 1829, 2014, 2307, 2495, 2536, 3248, 3408, 4143], 'activator': [70, 257], 'protein': [72, 89, 129, 166, 259, 276, 316, 353, 378, 1180, 2133], 'kinase': [73, 90, 130, 167, 260, 277, 317, 354, 379, 682, 1181, 2134, 3819, 3945], 'G,': [74, 91, 261, 278, 3187], 'inhibited': [75, 262, 3330, 4068, 4354], 'CPA-': [77, 264, 3276], 'or': [78, 95, 115, 265, 282, 302, 1766, 1815, 1835, 1996, 2065, 2343, 3236, 3277, 3542, 3613, 3815, 3943, 4156], 'thapsigargin-induced': [79, 266], 'concentration-dependent': [84, 271, 1694, 1925, 3335], 'manner.': [85, 272, 3336], 'An': [86, 273, 1086, 1470, 2564], 'inhibitor': [87, 274, 1566, 1742, 2308, 2452], 'KT5823': [92, 279, 1765, 1814, 1834, 1995, 2045, 2064, 2615, 2674, 2698, 3059, 3339, 3610, 3756, 4085], '(1': [93, 280, 3611, 4086, 4425], 'μm)': [94, 281, 2255, 2769, 3612, 4087], 'H-8': [96, 283, 1769, 2047, 2068, 2749, 2767, 2786, 3341, 3614], '(10': [97, 284, 2254, 2305, 2768, 3615], 'μm),': [98, 285, 1564, 2285, 2306, 3616], 'abolished': [99, 286, 1586, 1770, 2356, 2967, 3037, 3306], 'inhibitory': [101, 288, 1211, 1772, 3344], 'action': [102, 289, 1773], '8-bromo-cGMP': [104, 291], 'resumed': [106, 293, 1777, 3060], 'Addition': [109, 296, 2340], 'ofS-nitroso-N-acetylpenicillamine': [110, 297], '(a': [111, 117, 298, 304], 'oxide': [113, 300], 'donor)': [114, 301], 'dipyridamole': [116, 303, 2304, 2344, 3660], 'phosphodiesterase': [119, 306, 2311], 'inhibitor)': [120, 307], 'during': [121, 308, 2345, 3171], 'CPA': [122, 309, 1323, 1353, 1617, 1691, 1783, 1865, 2062, 2066, 2241, 2253, 2277, 2346, 2362, 2386, 2421, 2504, 2519, 2587, 2762, 2942, 2965, 3183, 3220, 3235, 3622, 3699, 3728, 4108], 'treatment': [123, 310, 2347, 2422, 2608, 2943, 3033, 3036, 3189, 3238, 3729], 'elevated': [124, 311, 486, 1200, 1378, 3458, 3642], 'cellular': [125, 312, 1094, 1155, 2197, 2243, 2337, 2350, 3411, 3443, 3624, 3667, 3681], 'levels,': [127, 314], 'stimulated': [128, 315, 2256, 4028], 'G': [131, 318, 380, 642, 1182], 'activity,': [132, 319], 'at': [134, 321, 585, 1705, 2266, 2706, 2917, 3120, 3200, 3381, 4044], 'same': [136, 323, 2998], 'time': [137, 324, 1436, 1880, 2074, 2275, 2690], 'reduced': [138, 325, 1685], 'influx': [140, 327, 396, 605, 866, 1331, 1443, 1481, 1980, 2002, 2359, 2632, 2818, 3270, 3479, 3619, 3652, 3696, 3777, 3792, 3813, 3941], 'due': [141, 328, 1615, 1689, 1781, 2360, 2791, 2810, 3697], 'CPA.': [143, 330, 2272, 2399, 3115, 3194, 3674, 4030], 'Patch': [144, 331], 'clamp': [145, 332, 2848, 3968], 'study': [146, 333, 1170], 'confirmed': [147, 334, 3596], 'existence': [149, 336], 'CPA-activated': [152, 339, 3007, 3974], 'Ca2+-permeable': [153, 340, 2864, 3132, 3136, 3975, 4099], 'channel': [154, 341, 2865, 2891, 2925, 2947, 2969, 3008, 3039, 3062, 3108, 3118, 3137, 3153, 3205, 3976, 3997, 4051, 4066, 4091, 4102], 'sensitive': [155, 342, 3138], 'inhibition.': [158, 345], 'These': [159, 346, 1220, 1401, 1789, 2644, 3348, 3675, 3771], 'results': [160, 347, 1221, 1402, 1654, 1790, 2514, 3434, 3772], 'suggest': [161, 348, 1222, 1403, 1791, 2527, 2646, 3260, 3350, 3773, 4141], 'that': [162, 349, 582, 590, 740, 1198, 1209, 1223, 1404, 1501, 1536, 1660, 1724, 1792, 1807, 2030, 2130, 2186, 2252, 2528, 2647, 2780, 3050, 3261, 3320, 3351, 3368, 3439, 3456, 3506, 3582, 3704, 3774, 3933, 3949, 4061, 4096, 4114, 4142, 4341, 4419], 'via': [164, 351, 3466, 3938], 'G-dependent': [168, 355], 'mechanism': [169, 356, 552, 1266, 3475, 3516, 3526], 'may': [170, 357, 477, 630, 1091, 1157, 1227, 1423, 1841, 2039, 2534, 2655, 2820, 3372, 3460, 3510, 3544, 3794, 3910], 'play': [171, 358, 1228, 2535], 'regulation': [177, 364, 1186, 1234, 3499], 'cytoplasmic': [374], 'free': [375], 'calcium': [376], 'concentration': [377, 4344, 4353, 4359, 4422], 'bromo': [381], 'cyclopiazonic': [382], 'phosphate-buffered': [384], 'saline': [385, 388, 392, 2878], 'normal': [386, 2580, 2758], 'physiological': [387, 391, 2581, 2759], 'solution': [389, 393, 1343, 1348, 2582, 2760, 2875, 2882], 'calcium-free': [390], 'S-nitroso-N-acetylpenicillamine': [394], 'nonexcitable': [398, 1017, 2201, 4133, 4139], 'regulates': [400], 'such': [401, 1487, 2828, 3512, 3807], 'diverse': [402, 990], 'processes': [403], 'as': [404, 723, 2494, 2547, 2829, 3245, 3450, 3808], 'gene': [405], 'regulation,': [406], 'contraction,': [407], 'exocytosis,': [408], 'apoptosis.': [410], 'these': [412, 483, 989, 1653, 3020], 'cells,': [413, 884, 1018, 1367, 3389, 3633, 4309], 'predominant': [415], 'pathway': [418, 518, 558, 1845, 2533, 2551, 2654, 2667, 2819, 3778, 3793, 3806], 'is': [419, 441, 559, 583, 591, 720, 1148, 1244, 1507, 1623, 1719, 1799, 1811, 1818, 1828, 2188, 2779, 3000, 3266, 3286, 3297, 3305, 3356, 3394, 3455, 3480, 3493, 3504, 3594, 3620, 3635, 3645, 3702, 3724, 3779, 4034, 4067, 4094, 4124], 'one': [422, 3932], '(1.Parekh': [423, 499, 533, 1291, 2457], 'A.B.': [424, 500, 534, 911, 930, 1292, 2458, 4273, 4292], 'Penner': [425, 501, 535, 667, 896, 912, 1293, 2459, 3856, 4164, 4274], 'R.': [426, 502, 536, 668, 897, 913, 1107, 1294, 1544, 1638, 2460, 3857, 4165, 4275], 'Physiol.': [427, 503, 537, 1038, 1067, 1079, 1295, 1313, 1548, 1747, 2461], 'Rev.': [428, 504, 538, 1126, 1296, 2462], '1997;': [429, 505, 539, 1297, 2463, 3572], '77:': [430, 506, 540, 1298, 2464], '901-930Crossref': [431, 507, 541, 1299, 2465], 'PubMed': [432, 508, 542, 622, 660, 678, 698, 715, 766, 786, 806, 832, 907, 924, 939, 1009, 1042, 1056, 1083, 1114, 1141, 1300, 1317, 1580, 1647, 2220, 2298, 2327, 2466, 2489, 3430, 3559, 3828, 3849, 3867, 3885, 3899, 4020, 4175, 4193, 4213, 4229, 4248, 4286, 4301, 4330, 4392, 4412], 'Scopus': [433, 509, 543, 623, 716, 807, 833, 925, 940, 1010, 1057, 1115, 1142, 1301, 1581, 1648, 2299, 2328, 2467, 2490, 3560, 3575, 3829, 3900, 4021, 4230, 4249, 4287, 4302, 4413], '(1287)': [434, 510, 544, 1302, 2468], 'Google': [435, 511, 545, 625, 661, 679, 699, 718, 767, 787, 809, 835, 908, 927, 942, 1012, 1043, 1059, 1071, 1084, 1117, 1144, 1303, 1318, 1583, 1650, 1751, 2221, 2301, 2330, 2469, 2492, 3431, 3562, 3577, 3831, 3850, 3868, 3886, 3902, 4023, 4176, 4194, 4214, 4232, 4251, 4289, 4304, 4331, 4393, 4415], 'Scholar),': [436, 680, 700, 1553, 1584, 1752, 2302, 2331, 2493, 4416], 'which': [438, 459, 469, 482, 554, 970, 2683, 2707, 3028, 3401, 3477, 3603, 3918, 4338], 'governed': [442], 'by': [443, 481, 553, 634, 814, 1216, 1264, 1335, 1445, 1483, 1510, 1668, 1801, 1813, 1833, 1882, 1927, 1984, 2020, 2076, 2281, 2638, 2692, 2785, 2824, 2986, 3078, 3247, 3268, 3288, 3299, 3307, 3311, 3331, 3360, 3597, 3654, 3753, 3782, 4000, 4029, 4069, 4373], 'content': [445, 2389, 2415], 'stores.': [449, 3234, 3280], 'Release': [450], 'from': [453, 463, 995, 1247, 1340, 1498, 1516, 2503, 2630, 2996, 3089, 3168, 3242, 3275, 3435, 3977, 4147], 'stores': [455, 493, 997, 1022, 1286, 1409], 'causes': [456, 3742, 3757], 'store': [457, 1328, 1427, 2855, 3440, 3656, 3800, 3908], 'depletion,': [458, 3801], 'then': [460, 1092, 1333, 1359, 1842, 1975, 3919], 'activates': [461, 1023, 1410, 1725, 3403, 4152], 'Ca2+entry': [462, 746, 1290, 2181, 2650, 4119], 'extracellular': [464, 1338, 1448, 1452, 1484, 1609, 3243, 3293], 'space.': [465], 'This': [466, 1275, 3006, 3524, 3593], 'entry,': [468, 476, 2235, 4349], 'has': [470, 519, 526, 561, 607, 1277, 2127, 2192, 4157], 'been': [471, 520, 563, 608, 2128, 2193], 'termed': [472, 602], 'be': [478, 632, 1214, 1982, 2656, 2788, 2821, 2844, 2928, 3130, 3329, 3373, 3960, 3991, 4104], 'basis': [480], 'maintain': [485], '[Ca2+]i': [487, 1373, 1458, 1506, 1590, 1665, 1687, 1939, 2016, 2025, 2559, 2621, 2628, 2752, 2809, 2842, 3265, 3285, 3537, 3541], '1and': [488], 'replenish': [489], 'their': [490, 4365, 4368], 'response': [495, 984], 'agonist': [497], 'stimulation': [498, 1270, 2264, 4109], 'Scholar).': [512, 546, 626, 810, 1013, 1085, 1145, 1319, 1651, 2159, 2222, 3432, 3578, 3903, 4024, 4305], 'The': [513, 1825, 1837, 1935, 1945, 2151, 2413, 2624, 2907, 2992, 3068, 3081, 3104, 3144, 3195, 3282, 3433, 3641, 3925], 'importance': [514], 'signaling': [517], 'recognized': [521], 'numerous': [523, 959], 'investigations': [524], 'received': [527], 'great': [529], 'deal': [530], 'attention': [532], 'However,': [547, 811, 1146, 1486, 2542, 2764, 3789, 4367], 'up': [548, 1466], 'now,': [550], 'regulated': [560, 633, 1800, 3482], 'still': [562], 'poorly': [564], 'understood.At': [565], 'least': [566, 3382], 'some': [568], 'cell': [569, 1434, 1496, 3549], 'types,': [570], 'activation': [571, 3816], 'appears': [576, 1806], 'involve': [578], 'soluble': [580], 'messenger': [581, 1723], 'generated': [584], 'capable': [592], 'modulating': [594], 'plasma': [595, 2800, 2830], 'membrane': [596, 1600, 2801, 2831, 3017, 3044, 3048, 3308], 'permeability.': [598], 'A': [599, 1413, 1786, 2135, 2863, 2920, 2954, 2975, 3177, 3768, 4081], 'putative': [600], 'mediator': [601], 'factor': [606, 3814, 3942], 'identified': [609, 2867], 'Jurkat': [611, 873], 'T': [612, 874], 'lymphocytes': [613], '(2.Randriamampita': [614, 3820], 'C.': [615, 664, 893, 3821, 3853, 4161], 'Tsien': [616, 3822], 'R.Y.': [617, 3823], 'Nature.': [618, 935, 3824, 4297], '1993;': [619, 654, 672, 760, 901, 936, 1006, 1577, 1748, 3825, 3843, 3861, 4169, 4187, 4298, 4386], '364:': [620, 937, 3826, 4299], '809-814Crossref': [621, 3827], '(785)': [624, 3830], 'several': [635], 'other': [636, 1016, 2200, 2606, 2660, 2825, 3906, 3948, 4132, 4138], 'factors,': [637, 969], 'including': [638], 'small': [639], 'molecular': [640], 'weight': [641], 'proteins': [643], '(3.Bird': [644], 'G.': [645, 774, 794, 821, 2208, 3418, 3834, 4201, 4217, 4237, 4318, 4400], 'St': [646, 822, 3835, 4238], 'J.': [647, 651, 669, 689, 711, 757, 777, 796, 823, 851, 898, 1037, 1052, 1066, 1078, 1109, 1136, 1312, 1547, 1576, 1636, 1643, 1746, 2211, 2292, 3421, 3836, 3840, 3858, 3876, 3895, 4015, 4166, 4184, 4204, 4219, 4239, 4267, 4321, 4383, 4402], 'Putney': [648, 815, 824, 847, 3837, 4240, 4263], 'Jr.,': [649, 825, 848, 3838, 4241, 4264], 'J.W.': [650, 826, 849, 3839, 4242, 4265], 'Biol.': [652, 670, 690, 758, 778, 899, 2212, 3422, 3571, 3841, 3859, 3877, 4167, 4185, 4205, 4322, 4384], 'Chem.': [653, 671, 691, 759, 779, 900, 2213, 3423, 3842, 3860, 3878, 4168, 4186, 4206, 4323, 4385], '268:': [655, 673, 761, 902, 1040, 1315, 3844, 3862, 4170, 4188, 4387], '21486-21488Abstract': [656, 3845], 'Full': [657, 675, 695, 763, 783, 904, 2217, 3427, 3846, 3864, 3882, 4172, 4190, 4210, 4327, 4389], 'Text': [658, 676, 696, 764, 784, 905, 2218, 3428, 3847, 3865, 3883, 4173, 4191, 4211, 4328, 4390], 'PDF': [659, 677, 697, 765, 785, 906, 2219, 3429, 3848, 3866, 3884, 4174, 4192, 4212, 4329, 4391], 'Scholar,': [662, 768, 836, 909, 928, 1044, 1060, 1072, 1118, 1130, 1304, 2470, 3563, 3832, 3851, 3869, 3887, 4177, 4195, 4215, 4233, 4252, 4271, 4290], '4.Fasolato': [663, 3852], 'Hoth': [665, 894, 3854, 4162], 'M.': [666, 895, 1033, 1308, 3855, 4007, 4011, 4163], '20737-20740Abstract': [674, 903, 3863, 4171], 'tyrosine': [681, 702, 3818, 3944], '(5.Vostal': [683], 'J.G.': [684, 3871], 'Jackson': [685, 3872], 'W.L.': [686, 3873], 'Shulman': [687, 3874], 'N.R.': [688, 1062, 3875], '1991;': [692, 1127, 1550, 2295, 3879], '266:': [693, 3880], '16911-16916Abstract': [694, 3881], 'phosphatase': [703], '(6.Jenner': [704], 'S.': [705, 776, 919, 1120, 2210, 2484, 3420, 3889, 4203, 4281, 4320], 'Farndale': [706, 3890], 'R.W.': [707, 3891], 'Sage': [708, 3892], 'S.O.': [709, 3893], 'Biochem.': [710, 850, 1051, 1575, 2322, 3894, 4266], '1994;': [712, 780, 1080, 2214, 3424, 3896, 4017, 4207, 4324], '303:': [713, 3897], '337-339Crossref': [714, 3898], '(46)': [717, 3901], 'Scholar).There': [719], 'controversy': [722], 'whether': [725, 1151, 1977, 2549], 'plays': [727, 2552, 3709], 'regulatory': [730, 2228, 3515], 'Several': [736, 3256], 'research': [737], 'groups': [738], 'proposed': [739, 3453, 4340], 'could': [742, 1981, 2927], 'activate': [743, 2511], 'pancreatic': [748, 869, 3387, 4307], 'acinar': [749, 870, 3388, 4308], '(7.Bahnson': [751, 4377], 'T.D.': [752, 4179, 4378], 'Pandol': [753, 4180, 4379], 'S.J.': [754, 2144, 4181, 4380], 'Dionne': [755, 4182, 4381], 'V.E.': [756, 4183, 4382], '10808-10812Abstract': [762, 4189, 4388], '8.Xu': [769, 4196], 'X.': [770, 819, 842, 2204, 3414, 4197, 4235, 4258, 4314], 'Star': [771, 2205, 3415, 4198, 4315], 'R.A.': [772, 2206, 3416, 4199, 4316], 'Tortorici': [773, 2207, 3417, 4200, 4317], 'Muallem': [775, 2209, 3419, 4202, 4319], '269:': [781, 2215, 3425, 4208, 4325], '12645-12653Abstract': [782, 2216, 3426, 4209, 4326], 'Scholar)': [788, 855, 4332, 4394], 'colonic': [790], 'epithelial': [791], '(9.Bischof': [793, 4399], 'Brenman': [795, 4218, 4401], 'Bredt': [797, 4220, 4403], 'D.S.': [798, 4221, 4404], 'Machen': [799, 4222, 4405], 'T.E.': [800, 4223, 4406], 'Cell': [801, 827, 4224, 4243, 4407], 'Calcium.': [802, 828, 4225, 4244, 4408], '1995;': [803, 852, 921, 1039, 1314, 4226, 4268, 4283, 4409], '17:': [804, 3573, 4227, 4410], '250-262Crossref': [805, 4228, 4411], '(48)': [808, 4231, 4414], 'subsequent': [812, 1441, 2955, 3031, 4082], 'studies': [813], 'co-workers': [817], '(10.Bian': [818], 'Bird': [820, 843, 4236, 4259], '1996;': [829, 1068, 4245], '19:': [830, 4246], '351-354Crossref': [831, 4247], '(15)': [834, 4250], '11.Gilon': [837, 4253], 'P.': [838, 4254], 'Obie': [839, 4255], 'J.F.': [840, 4256], 'Bian': [841, 4257], 'G.S.': [844, 4260], 'Dagorn': [845, 4261], 'J.C.': [846, 4262], '311:': [853, 4269], '645-656Google': [854, 4270], 'failed': [856], 'observe': [858], 'any': [859, 1159, 2772], 'effect': [860, 888, 1212, 1598, 1675, 1827, 2164, 2178, 2239, 2714, 2718, 2747, 3345, 4159], 'on': [863, 889, 1602, 1678, 1854, 2048, 2167, 2179, 2242, 2387, 2675, 2721, 2750, 4137], 'thapsigargin-evoked': [864], 'both': [868, 4041], 'Similarly,': [876], 'Xenopus': [878], 'oocytes': [879], 'rat': [881, 2391], 'basophilic': [882], 'leukemia': [883], 'had': [886, 2176, 3024], 'no': [887, 1370, 1455, 1819, 2177, 2545, 3743, 4158], 'Ca2+influx': [891, 1511], '(4.Fasolato': [892, 4160], '12.Parekh': [910, 4272], 'Proc.': [914, 2479, 4276], 'Natl.': [915, 2480, 4277], 'Acad.': [916, 2481, 4278], 'Sci.': [917, 2482, 4279], 'U.': [918, 1103, 2483, 4280], 'A.': [920, 1101, 1105, 2485, 4282], '92:': [922, 4284], '7907-7911Crossref': [923, 4285], '(154)': [926, 4288], '13.Parekh': [929, 4291], 'Terlau': [931, 4293], 'H.': [932, 4005, 4294], 'Stuehmer': [933, 4295], 'W.': [934, 1134, 4296], '814-818Crossref': [938, 4300], '(319)': [941, 4303], 'Scholar).Vascular': [943], 'vivo': [947], 'form': [948], 'interface': [950], 'between': [951, 1433], 'flowing': [952], 'blood': [953], 'tissue,': [956], 'responding': [957], 'humoral': [960], 'physical': [962], 'stimuli': [963], 'secrete': [965], 'relaxing': [966], 'contracting': [968], 'modulate': [971], 'contractility': [973], 'smooth': [976], 'muscle': [977], 'many': [980], 'cases,': [981], 'initial': [983, 2015], 'signals': [991], 'involves': [992], 'release': [994, 1515, 3274], '(14.Himmel': [998], 'H.M.': [999], 'Whorton': [1000], 'A.R.': [1001], 'Strauss': [1002], 'H.C.': [1003], 'Hypertension': [1004], '(Dallas).': [1005], '21:': [1007], '112-127Crossref': [1008], '(234)': [1011], 'Like': [1014], 'depletion': [1019, 1405, 2191, 3390, 3441, 3909], '(15.Pasyk': [1030], 'E.': [1031, 1306, 2290, 4013], 'Inazu': [1032, 1307, 4006], 'Daniel': [1034, 1309, 4012], 'E.E.': [1035, 1310], 'Am.': [1036, 1065, 1077, 1311, 1745], 'H138-H146Crossref': [1041, 1316], '16.Schilling': [1045], 'W.P.': [1046, 1574], 'Cabello': [1047], 'O.A.': [1048, 1572], 'Rajan': [1049], 'L.': [1050, 1074], '1992;': [1053], '284:': [1054], '521-530Crossref': [1055], '(164)': [1058], '17.Sharma': [1061], 'Davis': [1063], 'M.J.': [1064], '270:': [1069], 'H267-H274PubMed': [1070], '18.Vaca': [1073], 'Kunze': [1075], 'D.L.': [1076], '267:': [1081], 'C920-C925Crossref': [1082], 'increase': [1087, 1504, 1557, 2196, 2619, 2670, 2807, 3283, 3665, 3762, 4144], 'elevate': [1093, 2336], 'levels': [1096, 2245, 2280, 3445, 3626, 3669], '(19.Luckhoff': [1100], 'Pohl': [1102], 'Mulsch': [1104], 'Busse': [1106], 'Br.': [1108, 1135], 'Pharmacol.': [1110, 1125, 1137, 2323, 4016], '1988;': [1111], '95:': [1112], '189-196Crossref': [1113], '(254)': [1116], '20.Moncada': [1119], 'Palmer': [1121], 'R.M.J.': [1122], 'Higgs': [1123], 'E.A.': [1124], '43:': [1128], '108-143Google': [1129], '21.White': [1131], 'D.G.': [1132], 'Martin': [1133], '1989;': [1138, 1644], '97:': [1139, 1551], '683-690Crossref': [1140], '(36)': [1143], 'it': [1147, 2634, 3128], 'known': [1150, 1523, 1624, 3395], 'elevation': [1153, 1392, 1446, 3249, 3409], 'way': [1160], 'influence': [1161], 'store-activated': [1163], 'cells.This': [1169], 'was': [1171, 1324, 1332, 1369, 1377, 1666, 1670, 1940, 1953, 2003, 2018, 2368, 2423, 2508, 2566, 2635, 2699, 2711, 2850, 2866, 2984, 3009, 3109, 3166, 3198, 4362, 4370], 'performed': [1172], 'assess': [1174], '(PKG)': [1183], 'We': [1196, 1429, 1594, 2028, 2160, 3366], 'found': [1197], 'level': [1202, 2923, 4150], 'attenuated': [1203], 'might': [1213, 2787, 2843, 4103], 'mediated': [1215], 'PKG-dependent': [1218, 1803, 3364, 3468, 3922], 'mechanism.': [1219, 1804, 3365, 3924], 'PKG': [1226, 1741, 1756, 1809, 1832, 1840, 1852, 1900, 2012, 2131, 2367, 2784, 3337, 3371, 3586, 3629, 3634, 3643, 3684, 3722, 3752, 3783, 4111], 'cells.RESULTSCPA': [1243], 'mycotoxin': [1246], 'Aspergillus': [1248], 'andPenicillium.': [1249], 'It': [1250, 1805, 3296, 3304, 3503, 4093], 'selectively': [1251], 'inhibits': [1252, 4116], 'Ca2+-ATPase': [1255, 2456, 2832], 'prevents': [1257], 're-uptake,': [1259], 'thereby': [1260], 'stimulating': [1261], 'independent': [1267, 2496], 'receptor': [1269], 'inositol': [1272], '1,4,5-trisphosphate': [1273], 'formation.': [1274], 'chemical': [1276, 2797], 'become': [1278], 'major': [1280], 'tool': [1281, 2497], 'for': [1282, 1383, 1459, 1465, 1538, 1630, 1760, 1846, 1866, 2069, 2854, 3161, 3517, 4107], 'depleting': [1283], 'activating': [1288], '15.Pasyk': [1305], 'experiment,': [1322], 'applied': [1325, 3055], 'depletion.': [1329, 1428, 3657], 'initiated': [1334], 'changing': [1336], 'medium': [1339, 1422], 'Ca2+-free': [1342, 1421], '(0Ca2+-PSS)': [1344], 'Ca2+-containing': [1347], '(N-PSS).': [1349], 'Control': [1350], 'without': [1352, 1896, 2090, 2420, 2761, 3727], 'pretreatment': [1354], 'washed': [1356], 'maintained': [1360], 'briefly': [1361], '0Ca2+-PSS.': [1363], 'For': [1364, 2007, 3046], 'control': [1366, 2418, 3520, 3930], 'there': [1368], 'change': [1371, 1456, 2840, 3745], 'when': [1374, 1808], 'external': [1375, 1394, 3314], '(Fig.1': [1379], 'A).': [1380, 1400, 2365, 2623, 3255], 'contrast,': [1382], 'those': [1384, 1460, 2008, 2517, 3994], 'pretreated': [1386], 'with': [1387, 1657, 1696, 1864, 2011, 2116, 2371, 2398, 2407, 2518, 2612, 2872, 2912, 2988, 3738, 4036, 4048, 4127], '10': [1388, 1767, 1921, 1997, 2098, 2267], 'μm': [1389, 1701, 1764, 1768, 1914, 1922, 1994, 1998, 2099, 2614, 2697, 3057, 3755], 'CPA,': [1390], 'drastically': [1396, 2944], 'increased': [1397, 2005, 2278, 2945], '[Ca2+]i(Fig.': [1398, 1559], '1': [1399, 1560, 1592, 1619, 1763, 1893, 1913, 1993, 2088, 2095, 2584, 2613, 2685, 2696, 2958, 3056, 3254, 3316, 3754, 4073], 'Ca': [1411], '2+influx.': [1412], 'prolonged': [1414, 1489], 'exposure': [1415, 1435], 'cultured': [1417, 3447, 3735], 'result': [1425], 'relationship': [1432, 2995], '0Ca2+-PSS': [1438, 1464, 1476, 1492, 1863, 2057], 'triggered': [1444, 3653], 'Ca2+.': [1449, 1485], 'Elevation': [1450], 'caused': [1454, 1509, 1667, 2594, 2616, 3267], 'incubated': [1462], '30': [1468], 'min.': [1469, 1868, 2071], 'incubation': [1471, 1490], '60': [1473, 3175], 'min': [1474, 1873, 2268], 'resulted': [1477, 2629], 'evoked': [1482, 3287], 'often': [1493], 'led': [1494], 'detachment': [1497], 'cultureware.To': [1499], 'confirm': [1500], 'CPA-induced': [1503, 1662, 1855, 1931, 1978, 2000, 2049, 2168, 2180, 3038, 3590, 3617, 3655], 'indeed': [1508, 3595], 'instead': [1512, 3271], 'CPA-insensitive': [1517], 'blockers': [1524], 'Ca2+entry.': [1526, 2541], 'Ni2+': [1527, 2641, 2720, 3300], '(3': [1528], 'mm),': [1529], 'potent': [1531, 1737, 3224], 'blocker': [1532], 'competes': [1537], 'Ca2+-binding': [1539], 'sites': [1540], '(29.Winegar': [1541], 'B.D.': [1542], 'Kelly': [1543], 'Lansman': [1545], 'J.B.': [1546], '(Lond.).': [1549], '351-367Google': [1552], 'completely': [1554, 1611, 1708, 2966], 'blocked': [1555, 1709, 1812, 2637, 3298], 'B).': [1561, 1593, 1620, 1703, 1716, 1788, 2643, 3770], 'SKF-96365': [1562], '(50': [1563], 'receptor-mediated': [1568], '(30.Cabello': [1571], 'Schilling': [1573], '295:': [1578], '357-366Crossref': [1579], '(56)': [1582], 'rise': [1588, 1604, 1663, 1688, 1856, 1932, 2050, 2626, 2723, 2774, 3263], '(Fig.': [1591, 1618, 1713, 1784, 2026, 2363, 2381, 2938, 2949, 2971, 3253, 3686, 3730, 3766, 3916, 3985, 4076], 'tested': [1596, 1976, 2162, 2237, 2745], 'depolarization': [1601, 1622, 3309], '[Ca2+]i.': [1606, 1858, 1934, 2052, 2677, 2725, 2776], '80': [1607, 3312], 'mm': [1608, 1707, 1894, 1906, 1910, 1918, 2174, 2585, 2592, 2640, 2686, 2709, 2959, 3313, 3740, 4074], 'K+': [1610], 'suppressed': [1612], '[Ca2+]irise': [1614], 'Membrane': [1621], 'reduce': [1626], 'driving': [1628], 'force': [1629], '(31.Adams': [1633], 'D.J.': [1634], 'Barakeh': [1635], 'Laskey': [1637], 'van': [1639], 'Breemen': [1640], 'C.V.': [1641], 'FASEB': [1642], '3:': [1645], '2389-2400Crossref': [1646], '(375)': [1649], 'Therefore,': [1652, 2837], 'are': [1655, 3151, 3157, 4027], 'consistent': [1656, 4126], 'concept': [1659], 'Ca2+influx.8-Br-cGMP': [1669], 'examine': [1673], 'Application': [1682, 2589], '8-Br-cGMP': [1684, 1704, 1775, 1817, 1911, 1919, 1928, 1943, 2593, 2960, 3188, 3332, 3741, 4075, 4424], 'manner': [1695], 'IC50': [1698], '180': [1700], '(Fig.2': [1702], '2': [1706, 1785, 1905, 1909, 1917, 2173, 2591, 3318, 3739], '2,A': [1714], 'Since': [1717, 3116], 'second': [1722], 'PKG,': [1726, 3955], 'next': [1728], 'possible': [1731, 2227], 'involvement': [1732], 'PKG.': [1734, 1824, 1988], 'KT5823,': [1735, 2766], 'highly': [1739], 'specific': [1740], '(32.Grider': [1743], 'J.R.': [1744], '264:': [1749], 'G334-G340PubMed': [1750], 'H-8,': [1754, 1816, 1999], 'another': [1755, 2450], 'inhibitor,': [1757], 'purpose.': [1762], 'activity': [1810, 2373, 2380, 2926, 2948, 2970, 3040, 3063, 3630, 3644, 3685, 3723, 4063], 'longer': [1820], 'able': [1821], 'overall': [1826], 'inhibition': [1830, 1838, 1926, 1986, 2782, 3141, 3584, 3750], 'H-8.': [1836, 1923, 2100], 'open': [1843, 3795], 'entry.Figure': [1849], '2Effects': [1850], 'modulators': [1853], 'Cells': [1859, 2053, 2395, 2678], 'placed': [1861, 2055, 2680], '40': [1867, 2070], 'Chemicals': [1869], 'introduced': [1871], '5': [1872, 2364, 2382, 3101, 3731], 'prior': [1874, 1985], 'experiments.': [1877, 2505], 'At': [1878, 2072, 2273, 2400, 2688], 'indicated': [1881, 2075, 2402, 2691, 3246], 'thearrow,': [1883], 'media': [1885, 1891, 2080, 2086], 'changed': [1887, 2082, 3111], 'respective': [1890, 2085], 'containing': [1892, 2087, 2583], 'CaCl2': [1895, 2884, 3148], 'EGTA.A,': [1897], 'effects': [1898, 3534], 'modulators.': [1901], '○,': [1902, 2092], 'control;': [1903, 2093, 3180], '●,': [1904, 2094], '8-Br-cGMP;': [1907], '▿,': [1908], '+': [1912, 1920, 2063, 2067], 'KT5823;': [1915, 2716], '▾,': [1916, 2097], 'B,': [1924, 2717], 'peak': [1936, 1946, 2017], 'amplitude': [1937, 2905, 2978, 3159], 'plotted': [1941], 'versus': [1942], 'concentration.': [1944], 'value': [1947], 'absence': [1950], 'normalized': [1954, 2424], '100.': [1956], 'Each': [1957, 2101, 2726, 3164], 'point': [1958, 2102, 2705, 2727], 'represents': [1959, 2103, 2728], 'mean': [1961, 2105, 2730], '±': [1962, 2106, 2430, 2731, 2981, 3095, 3100], 'S.E.': [1963, 2107, 2431, 2732], '(n': [1964, 2108, 2182, 2733], '=': [1965, 2109, 2183, 2602, 2734], '6–12).View': [1966], 'Large': [1967, 2119, 2434, 2736, 3208], 'Image': [1968, 2120, 2435, 2737, 3209], 'Figure': [1969, 2121, 2436, 2738, 3210], 'ViewerDownload': [1970, 2122, 2437, 2739, 3211], 'Hi-res': [1971, 2123, 2438, 2740, 3212], 'image': [1972, 2124, 2439, 2741, 3213], 'Download': [1973, 2125, 2440, 2742, 3214], '(PPT)We': [1974, 2743], 'augmented': [1983], 'presence': [1991, 2060, 2963, 3192, 3608, 3672, 3926], 'significantly': [2004, 2669], '(Fig.3).': [2006], 'treated': [2010, 2397], 'inhibitors,': [2013], 'followed': [2019], 'rapid': [2022, 3759], 'decrease': [2023, 2598], '3).': [2027], 'speculate': [2029], 'quicker': [2031], 'refillings': [2032], 'Ca2+stores': [2035, 3393], 'under': [2036, 2560, 3124, 3785, 3796], 'condition': [2038, 3798], 'subsequently': [2040, 3402], 'suppress': [2041], 'Ca2+influx.Figure': [2042], '3Effects': [2043], 'arrow,': [2078], 'mmCaCl2': [2089], 'EGTA.': [2091], 'μmKT5823;': [2096], '8–12).': [2110], '*,': [2111], 'p': [2112], '<': [2113], '0.05': [2114], 'compared': [2115], 'control.View': [2118], '(PPT)It': [2126], 'reported': [2129, 2194, 3999, 4418], 'have': [2136, 3971], 'similarities': [2137], 'structure': [2139], 'substrate': [2141], 'specificity': [2142], '(33.Beebe': [2143], 'Corbin': [2145], 'J.D.': [2146], 'Boyer': [2147], 'P.D.': [2148], 'Krebs': [2149], 'E.G.': [2150], 'Enzymes.': [2152], '17.': [2153], 'Academic': [2154], 'Press,': [2155], 'New': [2156], 'York1986:': [2157], '43-106Google': [2158], 'thus': [2161], '8-Br-cAMP': [2166, 2175], 'Unlike': [2171], 'cGMP,': [2172, 3489], '15),': [2184], 'suggesting': [2185], 'PKA': [2187], 'involved.Store': [2190], '(8.Xu': [2203, 3413, 4313], 'To': [2223], 'further': [2224, 2348, 3664], 'explore': [2225], 'Fig.4': [2250], 'illustrates': [2251, 2703, 3319], 'production': [2258, 3398, 3809, 3913], 'Maximal': [2263], 'occurred': [2265], 'after': [2269, 2931, 3112], 'addition': [2270], 'point,': [2276], '13-fold.': [2282], 'SNAP': [2283, 2342, 3658], '(100': [2284], 'NO': [2287, 3492, 3543], 'donor': [2288], '(34.Southam': [2289], 'Garthwaite': [2291], 'Neurosci.': [2293], 'Lett.': [2294], '130:': [2296], '107-111Crossref': [2297], '(158)': [2300], '(35.Weishaar': [2312], 'R.E.': [2313], 'Burrows': [2314], 'S.D.': [2315], 'Kobylarz': [2316], 'D.C.': [2317], 'Quade': [2318], 'M.M.': [2319], 'Evans': [2320], 'D.B.': [2321], '1986;': [2324], '35:': [2325], '787-800Crossref': [2326], '(245)': [2329], 'levels.': [2339], 'raised': [2349, 2374], '(Fig.5': [2352, 3639, 3700], 'B)': [2353], 'almost': [2355, 3692], 'Endogenous': [2366], 'stimulated,': [2370], 'its': [2372, 2378, 2803], '∼95%': [2376], 'maximal': [2379], 'C).Figure': [2383], '4Effect': [2384], 'times,': [2403], 'samples': [2404], 'extracted': [2406], 'ethanol': [2408], 'determine': [2410], 'content.': [2412], '1.': [2426], 'Values': [2427], 'represent': [2428], 'means': [2429], '(n=': [2432], '6).View': [2433], '(PPT)For': [2441], 'all': [2442, 3042, 3065], 'above': [2444], 'experiments,': [2445], '36.Thastrup': [2471], 'O.': [2472], 'Cullen': [2473], 'P.J.': [2474, 3567], 'Drobak': [2475], 'B.K.': [2476], 'Hanley': [2477], 'M.R.': [2478], '1990;': [2486], '87:': [2487], '2466-2470Crossref': [2488], '(2986)': [2491], 'evaluate': [2499], 'our': [2500, 3125], 'findings': [2501], 'obtained': [2502, 3077], 'When': [2506, 4031], 'thapsigargin': [2507, 3237], 'influx,': [2513], 'similar': [2515, 3992], 'observed': [2521, 2929, 3010], '(data': [2522], 'shown).These': [2524], 'data': [2525, 2645, 3349, 4130], 'strongly': [2526], 'PKG-sensitive': [2530, 2653, 2816, 3706], 'important': [2537], 'they': [2543, 4339], 'give': [2544], 'indication': [2546], 'maintenance': [2557, 3716], 'basal': [2561, 2649, 3719, 3786, 4149], 'unstimulated': [2562, 3720, 3787], 'conditions.': [2563, 3721, 3788], 'attempt': [2565], 'therefore': [2567, 3470], 'made': [2568, 3029], 'address': [2570], 'issue.': [2572], 'Cultured': [2573], 'bathed': [2577, 2756], 'Ca2+without': [2586], 'pretreatment.': [2588, 2763], 'slight': [2597], 'Ca2+(n': [2601], '10).': [2603], 'On': [2604, 2658, 3904], 'hand,': [2607, 2661, 3907], 'large': [2618], '(Fig.6': [2622, 2642], 'KT5823-induced': [2625, 2722], 'since': [2633], 'rapidly': [2636], '3': [2639, 2708], 'through': [2651, 3362, 3476, 3803, 3954], 'low.': [2657], 'opening': [2662, 2813], 'can': [2668, 3328, 4088], '[Ca2+]i.Figure': [2671], '6Effect': [2672], 'resting': [2676, 2751], 'N-PSS,': [2682], 'contained': [2684, 3147], 'CaCl2.': [2687], 'upward': [2694], 'arrows,': [2695], 'added.': [2700, 2712], 'Thedownward': [2701], 'arrow': [2702], 'NiCl2': [2710], 'A,': [2713], '4–12).View': [2735], 'unlike': [2765], 'did': [2770], 'cause': [2771, 3677], 'immediate': [2773], 'One': [2777], 'possibility': [2778], 'slow,': [2789], 'probably': [2790], 'slow': [2793, 2812], 'diffusion': [2794], 'across': [2798], 'targeted': [2804], 'site.': [2805], 'Any': [2806], 'cancelled': [2822], 'out': [2823, 3013], '[Ca2+]i-reducing': [2826], 'mechanisms': [2827], 'Ca2+-ATPase.': [2836], 'net': [2839], 'very': [2845, 2921], 'little.A': [2846], 'patch': [2847, 2914, 2999, 3196, 3967], 'technique': [2849], 'search': [2853], 'depletion-activated': [2856], 'channels': [2857, 4026, 4042], 'isolated': [2859, 3978], 'cell-attached': [2870, 3016, 3983], 'mode': [2871, 3984], 'bath': [2874, 4070], 'being': [2876, 2883], 'KCl': [2877], 'pipette': [2881, 4033], 'saline.': [2885], 'Fig.': [2886, 2899, 3003, 3436, 3601], '7(A–C)': [2887], 'shows': [2888, 2902], 'single': [2890, 2993, 3152, 3204, 4050], 'current': [2892, 2908, 2977, 3154, 3158, 3169], 'traces': [2893, 2909], 'recorded': [2894, 2911, 3972], 'typical': [2897], 'experiment.': [2898], '7': [2900, 3004], '(E–G)': [2901], 'corresponding': [2904], 'histograms.': [2906], 'potential': [2915, 3075, 3088, 3197], 'held': [2916, 3199], '−100': [2918, 3201], 'mV.': [2919, 3202], 'low': [2922, 4343], 'immediately': [2930], 'formation': [2933], 'gigaohm': [2936], 'seal': [2937], '7,A': [2939], 'E).': [2941], '7,': [2950, 2972, 4077], 'B': [2951, 3181, 3688], 'F).': [2953], 'application': [2956, 3113, 3289, 4071, 4083], 'C': [2973, 3185, 4078], 'andG).': [2974], 'unitary': [2976], '−1.0': [2980], '0.5': [2982], 'pA': [2983], 'calculated': [2985], 'fitting': [2987], 'gaussian': [2990], 'functions.': [2991], 'channelI-V': [2994], 'displayed': [3001], 'D.': [3005], '11': [3012, 3021], '62': [3015], 'patches.': [3018, 3045, 3067], 'Among': [3019], 'patches,': [3022], 'seven': [3023, 3043, 3090], 'long-lasting': [3025], 'good': [3026], 'seals,': [3027], 'possible.': [3034], 'three': [3047, 3066], 'patches': [3049, 3092], 'lasted': [3051], 'even': [3052, 3726], 'longer,': [3053], 'KT5823.': [3058], 'slope': [3069, 3083], 'conductance': [3070, 3084, 3105, 4052], 'extrapolated': [3073], 'reversal': [3074, 3087], 'linear': [3079], 'regression.': [3080], 'average': [3082], 'different': [3091], '9.1': [3094], '1.4': [3096], 'picosiemens': [3097], '22': [3099], 'mV,': [3102], 'respectively.': [3103, 3163], 'reversed': [3119], 'positive': [3122, 4046], 'voltage': [3123, 4047], 'experimental': [3126], 'conditions,': [3127], 'should': [3129], 'channel.Figure': [3133], '7A': [3134], 'CPA-inducible': [3135], 'cGMP.': [3143], 'pipette/bath': [3145], 'solutions': [3146], 'saline/KCl': [3149], 'saline.A–C': [3150], 'traces.': [3155], 'E–G': [3156], 'histograms': [3160], 'A–C,': [3162], 'histogram': [3165], 'derived': [3167], 'activities': [3170], 'period': [3173], 's.': [3176], 'E,': [3179], 'andF,': [3182], 'treatment;': [3184], 'D,': [3203], 'current-voltage': [3206], 'relationship.View': [3207], '(PPT)DISCUSSIONIn': [3215], 'deplete': [3231], 'activated': [3239, 3638, 4427], 'space': [3244], 'lines': [3257], 'evidence': [3259], 'thapsigargin-insensitive': [3278], '1)': [3281], 'solution.': [3294], '2)': [3295], 'SKF-96365.': [3302], '3)': [3303], 'induced': [3310], 'K+(Fig.': [3315], 'B).Fig.': [3317], 'reverse': [3342, 4043], '8-Br-cGMP.': [3347], 'subjected': [3357], 'modulation': [3359], 'propose': [3367], 'crucial': [3374, 3495], 'components': [3375], 'controlling': [3377], 'cells.In': [3386], 'NO,': [3400], 'guanylate': [3404], 'cyclase,': [3405], 'leading': [3406], '4': [3437], 'indicate': [3438], 'elevates': [3442, 3623], 'well.': [3451], 'Our': [3452, 3579], 'model': [3454, 3580], 'turn': [3462], 'inhibit': [3463], 'pathway,': [3469], 'providing': [3471], 'negative': [3473], 'feedback': [3474, 3525, 3923], 'finely': [3481, 3961], 'depending': [3483], 'upon': [3484], 'contents': [3486], 'Ca2+,': [3488], 'NO.': [3491, 3539], 'signal': [3496], 'tone.': [3502, 3523], 'conceivable': [3505], 'need': [3511], 'fine': [3514], 'better': [3519], 'allows': [3528, 3956], 'avoid': [3532], 'detrimental': [3533], 'excessive': [3536], 'and/or': [3538], 'Excessive': [3540], 'lead': [3545], 'apoptosis': [3547], 'death': [3550], '(37.Murphy': [3551], 'M.P.': [3552], 'Biochim.': [3553], 'Biophys.': [3554], 'Acta.': [3555], '1999;': [3556], '1411:': [3557], '401-414Crossref': [3558], '(360)': [3561], '38.Balligand': [3564], 'J.L.': [3565], 'Cannon': [3566], 'Arterioscler.': [3568], 'Thromb.': [3569], 'Vasc.': [3570], '1845-1858Crossref': [3574], '(220)': [3576], 'predicts': [3581], 'will': [3587], 'substantially': [3588], 'augment': [3589], 'influx.': [3592], 'experiments': [3599], '3,': [3602], 'show': [3604], 'that,': [3605], 'augmented.Although': [3621], 'stimulates': [3628, 3935], 'maximally': [3637], 'C).': [3640, 3732], 'enough': [3647], 'offset': [3649], 'treatments': [3676], 'additional': [3678], 'increases': [3679], '5,': [3687], 'C)': [3690], 'abolish': [3693], 'A).It': [3701], 'likely': [3703, 4095], 'limited': [3712], '[Ca2+]iunder': [3718], 'substantial': [3725], 'Treatment': [3733], 'significant': [3744, 3761], '[Ca2+]i,': [3747], 'whereas': [3748, 4350], '6.': [3767], 'mostly': [3780], 'closed': [3781], 'phosphorylation': [3784], 'presumably': [3802], 'PKG-independent': [3805], '3.Bird': [3833], '5.Vostal': [3870], '6.Jenner': [3888], '4),': [3917], 'initiates': [3920], 'separate': [3929], 'mechanisms,': [3931], 'positively': [3934], 'negatively': [3950], 'attenuates': [3951], 'regulated.With': [3962], 'use': [3964], 'technique,': [3969], '7).': [3986], 'Its': [3987], 'properties': [3988], 'appear': [3989], 'previously': [3998, 4128], 'Zhang': [4001], 'et': [4002, 4311, 4375, 4397], 'al.': [4003, 4312, 4376, 4398], '(39.Zhang': [4004], 'Weir': [4008], 'B.': [4009], 'Buchnan': [4010], 'Eur.': [4014], '251:': [4018], '119-125Crossref': [4019], '(49)': [4022], 'Both': [4025], 'filled': [4035], 'high': [4037, 4352, 4421], 'concentrations': [4038], 'CaCl2,': [4040], 'around': [4053], '7–9.5': [4054], 'picosiemens.': [4055], 'demonstrated': [4060], 'G).': [4080], 'resume': [4089], 'activity.': [4092], 'particular': [4098], 'nonselective': [4100], 'cation': [4101], 'target': [4106], 'phosphorylation.Our': [4112], 'conclusion': [4113], 'published': [4129], 'Available': [4135], 'reports': [4136], 'either': [4151], '7.Bahnson': [4178], '9.Bischof': [4216], '10.Bian': [4234], 'Xu': [4310], 'described': [4333], '"biphasic': [4335], 'response,"': [4336], 'enhanced': [4347], 'No': [4357], 'quantitative': [4358], 'given': [4363], 'report.': [4366], 'hypothesis': [4369], 'supported': [4372], 'Bahnson': [4374], 'Bischof': [4396], 'who': [4417], 'mm)': [4426], 'store-operat': [4428]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2071193932', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2022, 'cited_by_count': 4}, {'year': 2020, 'cited_by_count': 3}, {'year': 2018, 'cited_by_count': 1}, {'year': 2017, 'cited_by_count': 2}, {'year': 2016, 'cited_by_count': 5}, {'year': 2015, 'cited_by_count': 1}, {'year': 2014, 'cited_by_count': 3}, {'year': 2013, 'cited_by_count': 1}, {'year': 2012, 'cited_by_count': 16}], 'updated_date': '2024-12-15T17:35:40.568023', 'created_date': '2016-06-24'}
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