Title: The deposition and formation of immune complexes in collagenous tissues
Abstract: Abstract In vitro techniques were employed to investigate the mechanisms by which immune complexes are deposited or formed within collagenous tissues from rabbits. In the eighteen different tissues studied, both free antibody and antigen were able to penetrate the tissues and form immune complexes, whereas the preformed immune complexes were almost completely excluded. In vitro studies with long tendons from rabbits revealed: (1) Immune complexes were formed and retained when either the soluble antigen was present prior to antibody exposure or the antibody was present prior to antigen exposure; (2) immune complexes were also formed and retained with cross-reactive antibody; (3) both IgG and IgM formed stable immune complexes in tissue; (4) antigen specific F(ab′) 2 was effective in forming insoluble immune complexes with antigen in tissue, whereas antigen specific Fab did not; (5) Fc pretreatment of tissue did not alter the formation or retention of immune complexes; (6) preformed immune complexes were excluded from both normal and antibody-treated tissue.
Publication Year: 1979
Publication Date: 1979-05-01
Language: en
Type: article
Indexed In: ['crossref', 'pubmed']
Access and Citation
Cited By Count: 15
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