Publication Information

{'id': 'https://openalex.org/W2070695299', 'doi': 'https://doi.org/10.1016/j.canlet.2005.10.026', 'title': 'Cytochrome P450 2A6 polymorphism in nasopharyngeal carcinoma', 'display_name': 'Cytochrome P450 2A6 polymorphism in nasopharyngeal carcinoma', 'publication_year': 2005, 'publication_date': '2005-12-28', 'ids': {'openalex': 'https://openalex.org/W2070695299', 'doi': 'https://doi.org/10.1016/j.canlet.2005.10.026', 'mag': '2070695299', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/16377082'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1016/j.canlet.2005.10.026', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S106234763', 'display_name': 'Cancer Letters', 'issn_l': '0304-3835', 'issn': ['0304-3835', '1872-7980'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5042337630', 'display_name': 'Danai Tiwawech', 'orcid': 'https://orcid.org/0000-0002-5023-7888'}, 'institutions': [{'id': 'https://openalex.org/I161296585', 'display_name': 'Tokyo University of Science', 'ror': 'https://ror.org/05sj3n476', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I161296585']}, {'id': 'https://openalex.org/I4210100251', 'display_name': 'National Cancer Institute of Thailand', 'ror': 'https://ror.org/011mar637', 'country_code': 'TH', 'type': 'facility', 'lineage': ['https://openalex.org/I4210100251']}, {'id': 'https://openalex.org/I74801974', 'display_name': 'The University of Tokyo', 'ror': 'https://ror.org/057zh3y96', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I74801974']}], 'countries': ['JP', 'TH'], 'is_corresponding': False, 'raw_author_name': 'Danai Tiwawech', 'raw_affiliation_strings': ['Research Division, National Cancer Institute, Bangkok 10400, Thailand', 'Unit of Human Biology and Genetics, Department of Biological Sciences, Graduate School of Science, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan'], 'affiliations': [{'raw_affiliation_string': 'Unit of Human Biology and Genetics, Department of Biological Sciences, Graduate School of Science, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan', 'institution_ids': ['https://openalex.org/I161296585', 'https://openalex.org/I74801974']}, {'raw_affiliation_string': 'Research Division, National Cancer Institute, Bangkok 10400, Thailand', 'institution_ids': ['https://openalex.org/I4210100251']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5047908861', 'display_name': 'Petcharin Srivatanakul', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210100251', 'display_name': 'National Cancer Institute of Thailand', 'ror': 'https://ror.org/011mar637', 'country_code': 'TH', 'type': 'facility', 'lineage': ['https://openalex.org/I4210100251']}], 'countries': ['TH'], 'is_corresponding': False, 'raw_author_name': 'Petcharin Srivatanakul', 'raw_affiliation_strings': ['Research Division, National Cancer Institute, Bangkok 10400, Thailand'], 'affiliations': [{'raw_affiliation_string': 'Research Division, National Cancer Institute, Bangkok 10400, Thailand', 'institution_ids': ['https://openalex.org/I4210100251']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5021351931', 'display_name': 'Anant Karalak', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210100251', 'display_name': 'National Cancer Institute of Thailand', 'ror': 'https://ror.org/011mar637', 'country_code': 'TH', 'type': 'facility', 'lineage': ['https://openalex.org/I4210100251']}], 'countries': ['TH'], 'is_corresponding': False, 'raw_author_name': 'Anant Karalak', 'raw_affiliation_strings': ['Pathology Division, National Cancer Institute, Bangkok 10400, Thailand'], 'affiliations': [{'raw_affiliation_string': 'Pathology Division, National Cancer Institute, Bangkok 10400, Thailand', 'institution_ids': ['https://openalex.org/I4210100251']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5009828327', 'display_name': 'Takafumi Ishida', 'orcid': 'https://orcid.org/0000-0002-0896-3069'}, 'institutions': [{'id': 'https://openalex.org/I161296585', 'display_name': 'Tokyo University of Science', 'ror': 'https://ror.org/05sj3n476', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I161296585']}, {'id': 'https://openalex.org/I74801974', 'display_name': 'The University of Tokyo', 'ror': 'https://ror.org/057zh3y96', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I74801974']}], 'countries': ['JP'], 'is_corresponding': True, 'raw_author_name': 'Takafumi Ishida', 'raw_affiliation_strings': ['Unit of Human Biology and Genetics, Department of Biological Sciences, Graduate School of Science, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan'], 'affiliations': [{'raw_affiliation_string': 'Unit of Human Biology and Genetics, Department of Biological Sciences, Graduate School of Science, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan', 'institution_ids': ['https://openalex.org/I161296585', 'https://openalex.org/I74801974']}]}], 'institution_assertions': [], 'countries_distinct_count': 2, 'institutions_distinct_count': 3, 'corresponding_author_ids': ['https://openalex.org/A5009828327'], 'corresponding_institution_ids': ['https://openalex.org/I161296585', 'https://openalex.org/I74801974'], 'apc_list': {'value': 4100, 'currency': 'USD', 'value_usd': 4100, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 2.0, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 50, 'citation_normalized_percentile': {'value': 0.881362, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 93, 'max': 94}, 'biblio': {'volume': '241', 'issue': '1', 'first_page': '135', 'last_page': '141'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T12334', 'display_name': 'Small Cell Lung Cancer', 'score': 0.9895, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T12334', 'display_name': 'Small Cell Lung Cancer', 'score': 0.9895, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10417', 'display_name': 'Advancements in Lung Cancer Research', 'score': 0.9844, 'subfield': {'id': 'https://openalex.org/subfields/2740', 'display_name': 'Pulmonary and Respiratory Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10375', 'display_name': 'Drug Metabolism and Pharmacogenomics', 'score': 0.9822, 'subfield': {'id': 'https://openalex.org/subfields/3004', 'display_name': 'Pharmacology'}, 'field': {'id': 'https://openalex.org/fields/30', 'display_name': 'Pharmacology, Toxicology and Pharmaceutics'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/cyp2a6', 'display_name': 'CYP2A6', 'score': 0.6934525}, {'id': 'https://openalex.org/keywords/cytochrome-p450', 'display_name': 'Cytochrome P450', 'score': 0.574156}], 'concepts': [{'id': 'https://openalex.org/C2778997737', 'wikidata': 'https://www.wikidata.org/wiki/Q1693598', 'display_name': 'Nasopharyngeal carcinoma', 'level': 3, 'score': 0.81426764}, {'id': 'https://openalex.org/C180754005', 'wikidata': 'https://www.wikidata.org/wiki/Q80726', 'display_name': 'Allele', 'level': 3, 'score': 0.73520744}, {'id': 'https://openalex.org/C135763542', 'wikidata': 'https://www.wikidata.org/wiki/Q106016', 'display_name': 'Genotype', 'level': 3, 'score': 0.71610266}, {'id': 'https://openalex.org/C196013638', 'wikidata': 'https://www.wikidata.org/wiki/Q14874295', 'display_name': 'CYP2A6', 'level': 5, 'score': 0.6934525}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.5995124}, {'id': 'https://openalex.org/C114246631', 'wikidata': 'https://www.wikidata.org/wiki/Q187661', 'display_name': 'Carcinogen', 'level': 2, 'score': 0.5394884}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.50337285}, {'id': 'https://openalex.org/C168007829', 'wikidata': 'https://www.wikidata.org/wiki/Q857299', 'display_name': 'Restriction fragment length polymorphism', 'level': 4, 'score': 0.42636803}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.3727128}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.3219605}, {'id': 'https://openalex.org/C526171541', 'wikidata': 'https://www.wikidata.org/wiki/Q407693', 'display_name': 'Cytochrome P450', 'level': 3, 'score': 0.28991663}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.24355984}, {'id': 'https://openalex.org/C134018914', 'wikidata': 'https://www.wikidata.org/wiki/Q162606', 'display_name': 'Endocrinology', 'level': 1, 'score': 0.23247075}, {'id': 'https://openalex.org/C62231903', 'wikidata': 'https://www.wikidata.org/wiki/Q1057', 'display_name': 'Metabolism', 'level': 2, 'score': 0.05229965}, {'id': 'https://openalex.org/C109650736', 'wikidata': 'https://www.wikidata.org/wiki/Q424440', 'display_name': 'CYP3A4', 'level': 4, 'score': 0.04085335}, {'id': 'https://openalex.org/C509974204', 'wikidata': 'https://www.wikidata.org/wiki/Q180507', 'display_name': 'Radiation therapy', 'level': 2, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D001189', 'descriptor_name': 'Aryl Hydrocarbon Hydroxylases', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D006899', 'descriptor_name': 'Mixed Function Oxygenases', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D009303', 'descriptor_name': 'Nasopharyngeal Neoplasms', 'qualifier_ui': 'Q000201', 'qualifier_name': 'enzymology', 'is_major_topic': True}, {'descriptor_ui': 'D011110', 'descriptor_name': 'Polymorphism, Genetic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D000328', 'descriptor_name': 'Adult', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000368', 'descriptor_name': 'Aged', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000369', 'descriptor_name': 'Aged, 80 and over', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001189', 'descriptor_name': 'Aryl Hydrocarbon Hydroxylases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D065637', 'descriptor_name': 'Cytochrome P-450 CYP2A6', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005260', 'descriptor_name': 'Female', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005838', 'descriptor_name': 'Genotype', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008875', 'descriptor_name': 'Middle Aged', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006899', 'descriptor_name': 'Mixed Function Oxygenases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009303', 'descriptor_name': 'Nasopharyngeal Neoplasms', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009303', 'descriptor_name': 'Nasopharyngeal Neoplasms', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D016133', 'descriptor_name': 'Polymerase Chain Reaction', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012150', 'descriptor_name': 'Polymorphism, Restriction Fragment Length', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1016/j.canlet.2005.10.026', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S106234763', 'display_name': 'Cancer Letters', 'issn_l': '0304-3835', 'issn': ['0304-3835', '1872-7980'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/16377082', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'display_name': 'Good health and well-being', 'id': 'https://metadata.un.org/sdg/3', 'score': 0.71}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 41, 'referenced_works': ['https://openalex.org/W1492157159', 'https://openalex.org/W1515703937', 'https://openalex.org/W1790660744', 'https://openalex.org/W1856158664', 'https://openalex.org/W1970541895', 'https://openalex.org/W1972406926', 'https://openalex.org/W1974993420', 'https://openalex.org/W1976888905', 'https://openalex.org/W1981316929', 'https://openalex.org/W1992877948', 'https://openalex.org/W2011140384', 'https://openalex.org/W2014970345', 'https://openalex.org/W2015362565', 'https://openalex.org/W2033977600', 'https://openalex.org/W2041675187', 'https://openalex.org/W2049057684', 'https://openalex.org/W2055139096', 'https://openalex.org/W2055622515', 'https://openalex.org/W2064682737', 'https://openalex.org/W2073133535', 'https://openalex.org/W2076244798', 'https://openalex.org/W2081021064', 'https://openalex.org/W2082119404', 'https://openalex.org/W2083207377', 'https://openalex.org/W2088561852', 'https://openalex.org/W2094932400', 'https://openalex.org/W2112919958', 'https://openalex.org/W2113796991', 'https://openalex.org/W2114255421', 'https://openalex.org/W2127614605', 'https://openalex.org/W2134325441', 'https://openalex.org/W2143481327', 'https://openalex.org/W2156826712', 'https://openalex.org/W2163209725', 'https://openalex.org/W2169420652', 'https://openalex.org/W2184557788', 'https://openalex.org/W2342414835', 'https://openalex.org/W2402503107', 'https://openalex.org/W2412181071', 'https://openalex.org/W3159825070', 'https://openalex.org/W4242614329'], 'related_works': ['https://openalex.org/W3023095530', 'https://openalex.org/W2560974577', 'https://openalex.org/W2370948200', 'https://openalex.org/W2349233961', 'https://openalex.org/W2171370504', 'https://openalex.org/W2087363717', 'https://openalex.org/W2071583942', 'https://openalex.org/W2054843958', 'https://openalex.org/W1936347095', 'https://openalex.org/W1541945634'], 'abstract_inverted_index': {'Nitrosamine': [0], 'has': [1], 'been': [2], 'identified': [3], 'as': [4, 146], 'a': [5, 15, 55, 68, 109, 135, 147], 'carcinogen': [6], 'for': [7, 88, 113, 150], 'nasopharyngeal': [8], 'carcinoma': [9], '(NPC).': [10], 'Here,': [11], 'we': [12], 'investigated': [13], 'if': [14], 'nitrosamine': [16], 'metabolizing': [17], 'gene,': [18], 'cytochrome': [19], 'P450': [20], '2A6': [21], '(CYP2A6)': [22], 'played': [23], 'an': [24, 85], 'important': [25], 'role': [26, 137], 'in': [27, 39, 138], 'NPC': [28, 41, 75, 89, 114, 139], 'development.': [29], 'Relationships': [30], 'between': [31, 54, 71], 'the': [32, 35], 'disease': [33], 'and': [34, 43, 60, 65, 74, 141], 'CYP2A6': [36, 72, 107, 131], 'were': [37], 'studied': [38], '74': [40], 'patients': [42], '137': [44], 'age-matched': [45], 'healthy': [46], 'controls': [47], 'by': [48], 'using': [49], 'PCR-RFLP': [50], 'assay': [51], 'to': [52, 92], 'distinguish': [53], 'wide': [56], 'type': [57], 'allele,': [58], '*1A,': [59], 'two': [61], 'mutant': [62, 82, 104], 'alleles,': [63], '*1B': [64], '*4C.': [66], 'Overall,': [67], 'significant': [69], 'association': [70], 'polymorphism': [73, 132], 'development': [76], 'was': [77], 'observed': [78], '(P<0.05).': [79], 'Individual': [80], 'with': [81, 94, 117], 'alleles': [83, 105], 'had': [84, 108], 'increased': [86, 111], 'risk': [87, 112, 148], 'when': [90, 115], 'compared': [91, 116], 'those': [93, 118], '*1A/*1A': [95, 121], '(OR=2.37,': [96], '95%': [97, 124], 'CI=1.27–4.46).': [98], 'In': [99], 'addition,': [100], 'males': [101], 'who': [102, 119], 'carried': [103, 120], 'of': [106], 'fivefold': [110], 'genotype': [122], '(OR=5.02,': [123], 'CI=1.82–14.14).': [125], 'It': [126], 'is': [127], 'thus': [128], 'suggested': [129], 'that': [130], 'may': [133, 143], 'play': [134], 'crucial': [136], 'susceptibility': [140], 'it': [142], 'be': [144], 'used': [145], 'marker': [149], 'NPC.': [151]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2070695299', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2022, 'cited_by_count': 1}, {'year': 2021, 'cited_by_count': 1}, {'year': 2020, 'cited_by_count': 1}, {'year': 2019, 'cited_by_count': 4}, {'year': 2018, 'cited_by_count': 3}, {'year': 2017, 'cited_by_count': 1}, {'year': 2015, 'cited_by_count': 3}, {'year': 2014, 'cited_by_count': 4}, {'year': 2013, 'cited_by_count': 1}, {'year': 2012, 'cited_by_count': 10}], 'updated_date': '2024-09-18T21:14:05.040187', 'created_date': '2016-06-24'}