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255], 'insufficiency.': [77], 'assessment': [80, 1579], 'adequately': [81], 'reflects': [82], 'free': [83, 174, 277, 356, 585, 1465, 1572], 'plasma': [85, 355, 390, 478, 1466, 1506], 'concentration.': [86], 'Full-Text': [87, 186], 'PDF': [88, 187, 237, 1451, 1546], 'insufficiency:': [90], 'Diagnosis': [91], 'patients': [93, 143, 162, 553, 565, 577, 592, 600, 657, 757, 782, 805, 843, 979, 1061, 1108, 1142, 1191, 1348, 1377, 1394, 1414, 1442], 'liver': [95, 145, 1398], 'cirrhosis': [96, 146, 312, 581, 596, 604, 611, 858, 872, 989, 1063, 1110, 1194, 1381, 1416], 'difficultJournal': [98], '54Issue': [101], '3PreviewWe': [102], 'were': [103, 338, 360, 415, 431, 461, 648, 698, 814, 976, 1038, 1272], 'very': [104, 140], 'interested': [105], 'by': [106, 134, 200, 391, 1178, 1287, 1329], 'letter': [108], 'Montagnese': [110], 'et': [111, 216, 1435, 1525], 'al.': [112], 'published': [113, 1498], 'this': [115, 305, 1041, 1510, 1619, 1639], 'issue': [116], 'Journal': [119], 'Hepatology': [121], '[1].': [122], 'Many': [123], 'recent': [124, 198], 'publications': [125], 'led': [126], 'us': [127], 'believe': [129], 'that': [130, 245, 1107, 1268, 1344, 1383, 1405, 1459, 1553, 1622], 'insufficiency,': [132], 'assays,': [138], 'was': [139, 374, 451, 528, 566, 573, 635, 752, 819, 838, 950], '[2–7].': [147], 'fact,': [149], 'transport': [151], '(cortisol': [153], 'binding': [154], 'albumin)': [157], 'are': [158, 1067, 1593], 'often': [159], 'decreased': [160], 'cirrhosis,': [164, 272, 631, 1352], 'leading': [165], 'reduced': [168, 267], 'bound': [169, 261], 'fraction': [170, 181, 262, 279], 'whereas': [173, 1353], 'concentration,': [176], 'active': [180], 'remains': [184], 'unchanged.': [185, 281], 'Open': [188], 'Access': [189], 'To': [190], 'Editor:': [192], 'We': [193, 282], 'read': [194], 'interest': [196, 1635], 'study': [199, 1620], 'Galbois': [201], 'colleagues': [203], '[[1]Galbois': [204, 1513], 'A.': [205, 213, 1514, 1522], 'Rudler': [206, 1515], 'M.': [207, 1434, 1516], 'Massard': [208, 1517], 'J.': [209, 497, 1432, 1518], 'Fulla': [210, 1519], 'Y.': [211, 1520], 'Bennani': [212, 1521], 'Bonnefont-Rousselot': [214, 1523], 'D.': [215, 1524], 'al.Assessment': [217, 1436, 1526], 'salivary': [224, 1533], 'preferred.J': [228, 1537], 'Hepatol.': [229, 1445, 1538], '2010;': [230, 1147, 1446, 1539], '52:': [231, 1447, 1540], '839-845Abstract': [232, 1541], 'Full': [233, 235, 1449, 1542, 1544], 'Text': [234, 236, 1450, 1543, 1545], 'PubMed': [238, 403, 515, 1150, 1185, 1336, 1547], 'Scopus': [239, 404, 516, 1151, 1186, 1337, 1548], '(93)': [240, 1549], 'Google': [241, 406, 518, 1153, 1188, 1339, 1452, 1550], 'Scholar],': [242, 1154, 1551], 'showed': [244, 612], 'measurement': [247, 353, 1280], 'considerably': [252, 567], 'overestimates': [253], 'hepato-adrenal': [257, 1557], 'syndrome': [258, 1558], 'because': [259, 1477], 'may': [265, 296, 1156], 'presence': [270], 'while': [273], 'more': [275, 574, 614, 1385, 1396, 1561], 'important': [276], 'would': [283], 'like': [284, 1074], 'report': [286], 'on': [287, 467, 1500], 'how': [288], 'abnormalities': [289, 1031, 1112, 1140, 1158, 1228, 1389], '24-h': [292, 536, 588, 1270], 'rhythm': [293, 460, 524, 743, 784, 826, 972, 1029, 1091, 1387, 1484], 'also': [297, 432], 'confound': [298], 'diagnosis': [300, 1555], 'patient': [306, 1042, 1511], 'population.': [307], 'Twenty': [308], 'outpatients': [309], 'biopsy-proven': [311], '[mean': [313], '(±SD)': [314], 'age': [315], '59': [316], '±': [317, 335, 662, 666, 708, 712, 718, 722, 732, 736, 764, 768, 845, 849, 874, 878, 897, 901, 920, 924, 936, 940, 1002, 1006, 1012, 1016], '11': [318], 'yr;': [319], 'Child’s': [320, 579, 594, 602, 609, 629, 856, 870, 981, 987, 1379], 'grade': [321], 'A:': [322], 'n': [323], '=': [324, 966], '14,': [325], 'B:': [326], '4,': [327], 'C:': [328], '2]': [329], 'nine': [331], 'healthy': [332, 549, 659, 761, 777, 808], 'volunteers': [333, 550, 660, 762, 778, 809], '(60': [334], '14': [336], 'yr)': [337], 'studied': [339, 1349], 'sleep': [342], 'laboratory': [343], 'under': [344, 1274], 'light-controlled': [345], 'conditions': [346], '[2].': [347], 'Venous': [348], 'blood': [349], 'samples': [350, 1468], 'for': [351, 417, 1236, 1297, 1420, 1568, 1585, 1607], '(PFC)': [358, 587], 'concentrations': [359, 426, 479, 687, 706, 895, 918, 960, 1289, 1602], 'obtained': [361, 416], 'hourly': [362], 'between': [363, 369, 437, 523, 656, 828, 952], '18:00': [364], '10:00': [366, 370], 'two-hourly': [368], '18:00.': [372], 'PFC': [373, 409, 425, 459, 537, 561, 652, 678, 705, 729, 742, 863, 894, 917, 959, 971, 1198, 1206, 1242], 'measured': [375], 'using': [376], 'radioimmunoassay': [378], '[[3]Read': [379], 'G.F.': [380], 'Fahmy': [381], 'D.R.': [382], 'Walker': [383], 'R.F.': [384], 'Determination': [385], 'human': [389], 'radioimmunoassay.': [392], 'Use': [393], '125I-labelled': [396], 'radioligand.Ann': [397], 'Clin': [398], 'Biochem.': [399], '1977;': [400], '14:': [401], '343-349Crossref': [402], '(20)': [405], 'Scholar].': [407, 1189, 1340, 1453], 'Absolute': [408], 'values': [410, 653, 864, 1199, 1207], 'at': [411, 654, 1200, 1417], '08.00': [412, 862, 1201], '(‘morning': [413], 'cortisol’)': [414], 'each': [418], 'subject.': [419], 'Means': [420], 'five': [423, 442, 446, 703, 892, 915, 957], 'lowest/highest': [424, 704], 'over': [427, 688, 1208], '24': [429, 1210], 'h': [430, 1211], 'obtained.': [433, 801], 'The': [434, 453, 1190, 1261, 1341, 1612], 'mathematical': [435], 'difference': [436, 818], 'mean': [439, 651, 889, 912], 'lowest': [443, 893, 958], 'highest': [447, 916], 'values,': [448], 'or': [449, 727, 1244, 1463, 1632], 'range,': [450], 'calculated.': [452], 'onset': [454, 525, 744, 973, 1025, 1485], 'offset': [456, 527, 785, 795, 827, 975, 1010], 'defined': [462], 'as': [463, 1472], 'time': [465, 521], 'points,': [466], 'rise': [469], 'fall': [471], 'concentration–time': [474, 538, 679], 'curve,': [475], 'when': [476], 'equalled': [480], '25%': [481], 'peak': [484, 530, 562, 623, 837, 1037], 'concentration': [485], '[[4]Gogenur': [486], 'I.': [487], 'Ocak': [488], 'U.': [489], 'Altunpinar': [490], 'O.': [491], 'Middleton': [492, 1124], 'B.': [493, 1125], 'Skene': [494, 1128], 'D.J.': [495, 1129], 'Rosenberg': [496], 'Disturbances': [498], 'melatonin,': [500, 1075], 'core': [503], 'body': [504], 'temperature': [505], 'rhythms': [506, 1164, 1175, 1271, 1326, 1373], 'after': [507, 787], 'major': [508], 'surgery.World': [509], 'J': [510, 1145], 'Surg.': [511], '2007;': [512], '31:': [513], '290-298Crossref': [514], '(58)': [517], 'Scholar];': [519], 'interval': [522], 'termed': [529], 'duration.': [531], 'Visual': [532], 'analysis': [533], 'curves': [539, 590, 680], '(Fig.': [540, 569, 582, 692, 990], '1)': [541], 'revealed': [542], 'morning': [544, 690, 1406, 1461], '‘double-peak’': [545], 'both': [547, 1160], 'cirrhosis.': [555], 'However,': [556, 1367, 1454], 'timing': [558, 619, 823, 1058], 'delayed': [568, 754, 977], '1).': [570, 693, 773], 'This': [571], 'feature': [572], 'prominent': [575, 615], 'B/C': [580, 603, 610, 857, 982, 1380], '2).Fig.': [583], '2Plasma': [584], 'concentration-time': [589], 'A': [595, 630, 741, 871, 988, 1020], '(black': [597], 'circles)': [598], '(grey': [605], 'triangles).': [606], 'Patients': [607, 854], 'delay': [616, 1022, 1481], 'compared': [624, 758, 865, 983, 1212], 'their': [626, 867, 1214], 'counterparts': [627, 868], 'although': [632, 908], 'statistical': [633, 998], 'significance': [634, 999], 'not': [636, 799, 909, 996, 1285, 1625], 'reached.View': [637], 'Large': [638], 'Image': [639], 'Figure': [640], 'ViewerDownload': [641], 'Hi-res': [642], 'image': [643], 'Download': [644], '(PPT)': [645], 'No': [646], 'differences': [647, 697, 994], 'observed': [649, 699, 820, 951, 1039, 1357, 1480], '08:00': [655], '(212': [661], '102': [663], 'vs.': [664, 710, 720, 734, 766, 847, 876, 899, 922, 938, 1004, 1014], '171': [665], '67': [667], 'nmol/L,': [668, 714, 724, 738, 880, 903, 926, 942], 'p=': [669, 715, 725, 739, 770, 852, 881, 904, 927, 943, 1008, 1018], '0.29),': [670], 'most': [671, 1068, 1345, 1358], 'likely': [672, 1069], 'reflecting': [673], 'shape': [675, 1488], 'considerable': [683, 1021], 'variability': [684], 'hours': [691], 'Similarly,': [694], 'no': [695, 816], 'significant': [696, 817], 'average': [702], '(51': [707], '19': [709], '53': [711], '12': [713, 898], '0.60;': [716], '248': [717], '76': [719], '211': [721], '37': [723], '0.20)': [726], 'range': [730, 934], '(196': [731], '73': [733], '157': [735], '34': [737], '0.12).': [740], 'identified': [747], 'all': [749], 'subjects;': [750], 'it': [751, 1455], 'significantly': [753, 839, 860, 910, 1196], '(05:24': [763], '02:06': [765], '03:54': [767], '01:00,': [769], '0.02,': [771], 'Fig.': [772], 'two': [775, 830], '(22%)': [776], 'seven': [780, 807], '(35%)': [781], 'occurred': [786], '18:00,': [788], 'beyond': [789], 'sampling': [790], 'time,': [791], 'thus': [792, 1308], 'parameters': [794, 813], 'duration': [797, 834, 1034], '13': [804], 'whom': [811], 'obtained,': [815], 'groups': [831], 'but': [832, 992], 'shorter': [840], '(7.0': [844], '3.8': [846], '10.6': [848], '2.3': [850], 'h,': [851], '0.03).': [853], 'had': [859, 886, 1195, 1350], 'lower': [861, 933, 1197], '(135': [873], '42': [875], '246': [877], '103': [879], '0.04).': [882, 944], 'addition,': [884, 946], 'they': [885, 1066, 1623], 'higher': [888], '(61': [896], '48': [900], '20': [902], '0.05),': [905], 'lower,': [907], 'different,': [911], '(208': [919], '74': [921], '264': [923], '72': [925], '0.12)': [928], 'and,': [929, 1290, 1576], 'consequence,': [931], '(148': [935], '75': [937], '217': [939], '63': [941], 'direct': [948, 1078], 'correlation': [949], 'means': [954], 'Pugh’s': [963], 'score': [964], '(R': [965], '0.64,': [967], 'p<0.01).': [968], 'Both': [969], 'those': [985, 1361], '2)': [991], 'did': [995], 'reach': [997], '(onset': [1000], '06:12': [1001], '01:48': [1003], '05:06': [1005], '02:12,': [1007], 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[1137], 'cirrhosis.Am': [1144], 'Gastroenterol.': [1146], '105:': [1148], '1773-1781Crossref': [1149], '(60)': [1152], 'explain': [1157], 'melatonin': [1161, 1172, 1323, 1589], '[[5]Boivin': [1165, 1316], 'D.B.': [1166, 1317], 'Czeisler': [1167, 1318], 'C.A.': [1168, 1319], 'Resetting': [1169, 1320], 'humans': [1177, 1328], 'ordinary': [1179, 1330], 'room': [1180, 1331], 'light.Neuroreport.': [1181, 1332], '1998;': [1182, 1333], '9:': [1183, 1334], '779-782Crossref': [1184, 1335], '(114)': [1187, 1338], 'decompensated': [1193, 1363], 'less': [1203], 'variation': [1204], 'compensated': [1215, 1351], 'counterparts.': [1216], 'These': [1217], 'findings': [1218], 'might': [1219, 1390, 1559], 'relate': [1220], 'to:': [1221], '(i)': [1222, 1278], 'per': [1225], 'se;': [1226], '(ii)': [1227, 1291], 'metabolism,': [1231], 'responsible': [1235], 'increase': [1238], 'low': [1241], 'values;': [1243], '(iii)': [1245], 'sympathetic–parasympathetic': [1246], 'imbalance,': [1247], 'affect': [1250], 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