Publication Information

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[61], '309-310Crossref': [62], '(387)': [65], 'Scholar).': [67, 181, 252, 1003, 1075, 1123, 1159, 1264, 1344, 1368, 1402, 1454, 1607, 1862, 1893, 2007, 2049, 2419, 2577, 2727, 2986, 3092], 'It': [68, 1910, 2372, 3194, 3241, 3259, 3315], 'subsequently': [70], 'found': [71, 306, 476, 1830, 1916, 2218, 2870], 'this': [73, 284, 558, 1272, 1866, 2765, 3015], 'present': [76, 3371], 'large': [79, 1020, 3267], 'variety': [80], 'proteins': [82, 157, 256, 1712, 2444], 'involved': [83, 2440, 2834], 'cellular': [85, 265], 'signaling': [86, 134, 266, 309], 'or': [87, 267, 303, 1673, 2156, 2370, 3238], 'cytoskeletal': [88, 268], 'functions': [89], '(reviewed': [90], 'by7Gibson': [91], 'T.J': [92, 159, 230], 'Hyvönen': [93, 160, 231], 'M': [94, 98, 161, 165, 232, 236, 329, 1139, 1143, 1147, 1149, 1314, 1444, 1577, 1725, 1990, 2497, 2949, 2953, 2957, 2959], 'Musacchio': [95, 162, 233], 'A': [96, 163, 234, 1357, 1491], 'Saraste': [97, 164, 235, 1146, 2956], 'Birney': [99, 166, 237], 'E': [100, 167, 238], 'Trends.': [101, 168, 239], 'Biochem.': [102, 169, 240, 1445], 'Sci.': [103, 170, 241, 1255, 1301], '1994;': [104, 171, 242, 995, 1116, 1336, 1394, 1512, 1565, 1599, 2979, 3084], '19:': [105, 172, 243], '349-353Abstract': [106, 173, 244], '(295)': [112, 179, 250], 'Scholar),': [114, 1205, 1520, 3120], 'and': [115, 123, 197, 204, 215, 217, 312, 417, 440, 450, 488, 544, 562, 575, 582, 591, 633, 695, 779, 843, 928, 957, 1084, 1098, 1224, 1284, 1421, 1477, 1543, 1615, 1626, 1662, 1743, 1796, 1812, 1837, 1870, 1925, 2017, 2071, 2093, 2110, 2130, 2143, 2160, 2193, 2209, 2223, 2261, 2283, 2303, 2305, 2331, 2341, 2354, 2436, 2463, 2482, 2580, 2644, 2676, 2685, 2740, 2794, 2809, 2818, 2868, 2881, 2886, 2921, 2998, 3011, 3025, 3036, 3069, 3149, 3268, 3333, 3346, 3350], 'it': [116, 474, 1027, 1034, 1175, 3173], 'suggested,': [118], 'by': [119, 148, 287, 392, 447, 535, 649, 670, 684, 711, 729, 797, 818, 832, 860, 878, 1185, 1533, 1548, 1783, 1969, 2085, 2337, 2363, 2939], 'analogy': [120], 'with': [121, 273, 597, 674, 697, 822, 845, 1018, 1047, 1091, 1221, 1236, 1287, 1348, 1427, 1552, 1659, 1865, 1871, 1973, 2020, 2080, 2116, 2291, 2584, 2641, 2662, 2822, 2854, 2899, 2915, 2934, 3049, 3131, 3138, 3285], 'SH2': [122, 734, 883, 1800, 1810], 'SH3': [124, 745, 894], 'domains,': [125, 410, 976, 1079, 1227, 2176, 2213, 2684, 3134, 3172], 'PH': [127, 143, 182, 259, 280, 386, 409, 425, 461, 482, 586, 615, 634, 651, 680, 777, 799, 828, 926, 946, 975, 1015, 1024, 1040, 1078, 1126, 1226, 1230, 1273, 1381, 1417, 1457, 1554, 1624, 1629, 1656, 1775, 1902, 2059, 2111, 2144, 2154, 2201, 2212, 2236, 2249, 2278, 2314, 2385, 2429, 2432, 2458, 2484, 2548, 2646, 2668, 2683, 2733, 2781, 2807, 2829, 2841, 2850, 2916, 3000, 3067, 3100, 3133, 3140, 3147, 3171, 3186, 3205, 3217, 3254, 3272, 3323, 3342, 3357], 'domains': [128, 144, 183, 260, 281, 301, 396, 412, 426, 462, 483, 616, 746, 895, 947, 1677, 1776, 1789, 2052, 2112, 2142, 2145, 2155, 2190, 2206, 2279, 2433, 2485, 2647, 2917, 3187, 3206, 3255, 3273, 3324, 3343, 3358], 'might': [129, 3359], 'mediate': [130], 'protein–protein': [131], 'interactions': [132, 773, 922, 1169, 2267, 2464, 2554, 2632, 3045, 3137, 3248, 3298], 'processes.': [135], 'Since': [136, 743, 892, 2203], 'then,': [137], 'more': [138], 'than': [139, 2149], '90': [140, 3203], 'different': [141, 1798, 1805, 1927, 2153, 2241, 2940], 'putative': [142], 'have': [145, 297, 427, 936, 1086, 2053, 2179, 2686, 3208, 3310, 3325], 'been': [146, 428, 937, 971, 1087, 1781, 2687], 'analysis,': [150], 'at': [151, 431, 467, 1816, 1904, 2445, 2925], 'various': [152, 2175, 3221], 'positions': [153, 3008], 'their': [155, 443, 2243, 2259, 2287, 2451, 2627, 3129, 3326], 'host': [156, 2323], '(7Gibson': [158, 229], 'occur': [184], 'kinases': [187, 1836], 'such': [188, 211, 950, 3265], 'β': [191, 532, 540, 569, 2067, 2078, 3005, 3367], 'adrenergic': [192], 'receptor': [193, 403, 1834, 1924, 1976, 2023, 2344, 2860], '(βARK),': [195], 'Akt,': [196], 'Btk;': [198], 'phospholipase-C': [200], 'isoforms': [201], '(PLCβ,': [202], 'γ,': [203], 'δ);': [205], 'guanine': [207, 2357, 2377], 'nucleotide': [208, 2358, 2378], 'releasing': [209, 2379], 'factors': [210], 'Cdc25,': [213], 'Sos,': [214, 759, 908], 'Dbl;': [216], 'GTPase': [220, 2422], 'dynamin': [221, 2922], 'well': [223, 1641, 2541, 3228], 'GTPase-activating': [226], 'Ras-Gap': [228, 2437], 'Many': [253, 934], 'contain': [258, 656, 804], 'play': [261], 'role': [263, 2311], 'organization': [269], 'requires': [271, 1051, 1371], 'association': [272, 286], 'cell': [274, 2293, 2327, 3330], 'membranes.': [275, 3292], 'Recent': [276, 1403], 'studies': [277, 296, 439], 'suggest': [278, 1612, 3295], 'contribute': [282], 'to': [283, 289, 381, 398, 414, 420, 640, 653, 678, 707, 717, 740, 751, 765, 801, 826, 856, 866, 889, 900, 914, 941, 963, 1005, 1031, 1089, 1102, 1135, 1171, 1234, 1271, 1351, 1470, 1482, 1540, 1637, 1773, 1874, 1900, 1912, 2125, 2276, 2320, 2325, 2329, 2346, 2366, 2395, 2450, 2471, 2479, 2545, 2665, 2692, 2730, 2775, 2820, 2838, 2995, 3014, 3057, 3097, 3128, 3176, 3262, 3283, 3290, 3302, 3312, 3336, 3379], 'membrane': [285, 422, 699, 709, 767, 781, 847, 858, 916, 930, 1183, 1207, 1430, 1476, 2296, 2306, 2328, 2448, 3225], 'binding': [288, 612, 677, 712, 825, 861, 962, 1184, 1208, 1289, 1370, 1464, 1537, 1671, 2365, 2478, 2544, 2664, 2729, 2837, 3096, 3301], 'lipid': [290, 1105, 2307], 'molecules.': [291], 'In': [292], 'addition,': [293], 'recent': [294], 'structural': [295, 469, 2185, 3354], 'shown': [298, 1088], 'phosphotyrosine-recognition': [300], '(PTB': [302], 'PI': [304], 'domains),': [305], 'adapters': [310], 'Shc': [311, 416, 704, 726, 853, 875, 1713, 1802, 1826, 1876, 1931, 1961, 2159, 2192, 2208, 2302, 2367, 2481, 2643, 2780, 2806, 2867, 2997, 3146, 3347], 'IRS-1,': [313, 2282, 2304], 'adopt': [314], 'same': [316, 2056, 2181], 'fold': [317], '(20Zhou': [318, 1714, 1979, 2486], 'M.-M': [319, 1715, 1980, 2487], 'Ravichandran': [320, 1716, 1981, 2488], 'K.S': [321, 1717, 1982, 2489], 'Olejniczak': [322, 1718, 1983, 2490], 'E.T': [323, 1719, 1984, 2491], 'Petros': [324, 1720, 1985, 2492], 'A.M': [325, 1721, 1986, 2493], 'Meadows': [326, 1722, 1987, 2494], 'R.P': [327, 1723, 1988, 2495], 'Sattler': [328, 1724, 1989, 2496], 'Harlan': [330, 1726, 1991, 2498], 'J.E': [331, 1108, 1727, 1992, 2499, 2971], 'Wade': [332, 1728, 1993, 2500], 'W.S': [333, 1729, 1994, 2501], 'Burakoff': [334, 1730, 1995, 2502], 'S.J': [335, 1731, 1996, 2503], 'Fesik': [336, 1113, 1732, 1997, 2504, 2976], 'S.W': [337, 1114, 1733, 1998, 2505, 2977], '1995;': [339, 502, 523, 627, 1068, 1152, 1198, 1257, 1303, 1447, 1685, 1698, 1735, 1855, 1886, 2000, 2414, 2507, 2567, 2703, 2724, 2751, 2962, 3113], '378:': [340, 1736, 2001, 2508], '584-592Crossref': [341, 1737, 2002, 2509], '(324)': [344, 1740, 2005, 2512], '4Eck': [347, 2515, 2588], 'M.J': [348, 1141, 1355, 1390, 1489, 1508, 1561, 1746, 1935, 2026, 2516, 2589, 2951], 'Dhe-Paganon': [349, 1747, 1936, 2027, 2517, 2590], 'S': [350, 1320, 1359, 1493, 1583, 1748, 1937, 2028, 2518, 2591], 'Trüb': [351, 1749, 1938, 2029, 2519, 2592], 'T': [352, 1316, 1388, 1506, 1559, 1579, 1750, 1939, 2030, 2520, 2593], 'Nolte': [353, 1751, 1940, 2031, 2521, 2594], 'R.T': [354, 1752, 1941, 2032, 2522, 2595], 'Shoelson': [355, 1753, 1942, 2033, 2523, 2596], 'S.E': [356, 1754, 1943, 2034, 2524, 2597], '1996;': [358, 1756, 1945, 2036, 2526, 2599], '85': [359, 1757, 1946, 2037, 2527, 2600], '(this': [360, 1758, 1947, 2038, 2528, 2601], 'issue)Abstract': [361, 1759, 1948, 2039, 2529, 2602], '(253)': [369, 1767, 1956, 2047, 2537, 2610], 'Scholar[this': [371], 'issue': [372], 'Cell).': [374], 'PTB': [376, 395, 411, 1788, 1814, 1827, 1877, 1896, 1932, 1962, 2010, 2051, 2109, 2141, 2162, 2189, 2205], 'thus': [379, 763, 912, 1544], 'likely': [380, 3317], 'represent': [382, 2226, 3299], 'another': [383], 'class': [384, 1654, 2229], 'not': [390, 1029, 1779, 2864, 3196, 3321], 'recognized': [391], 'homology.': [394, 1785], 'bind': [397, 1090, 1868, 2622, 3284], 'phosphotyrosines': [399], 'particular': [401], 'activated': [402, 724, 731, 873, 880, 1833], 'tyrosine': [404, 720, 869, 1835], 'kinases,': [405], 'so,': [406], 'like': [407], 'other': [408, 1077, 1525, 3132, 3185], 'serve': [413], 'bring': [415], 'IRS-1': [418, 1744, 1895, 2009, 2161, 2194, 2210, 2353, 2483, 2645, 2849, 2999], 'close': [419, 2449], 'surface.': [423, 768, 917], 'Several': [424, 1076], 'successfully': [429], 'expressed': [430], 'high': [432, 1238, 1349, 1660, 1872, 2232, 2475, 3165, 3181, 3328], 'levels': [433], 'E.': [435], 'coli,': [436], 'allowing': [437, 2814], 'biochemical': [438], 'determination': [441, 1667], 'three': [444, 2930], 'dimensional': [445], 'structures': [446, 479, 2103], 'X-ray': [448], 'crystallography': [449], 'NMR': [451, 1970], 'spectroscopy.': [452], 'Despite': [453], 'fact': [455], 'identities': [459], 'between': [460, 567, 774, 923, 2140, 2152, 2157, 2173, 2682, 2816, 3022, 3060, 3144, 3356], 'are': [463, 490, 636, 749, 898, 1617, 1797, 1829, 2211, 2289, 2461, 2468, 2648, 2658, 2679, 2863, 2869, 3256], 'below': [464], 'level': [466], 'which': [468, 1378, 2269, 2389], 'can': [471, 2113, 2195, 3370], 'be': [472, 689, 837, 1172, 1774, 2114, 2196, 2439, 2472, 3055, 3189, 3313], 'assumed,': [473], 'from': [484, 694, 842, 980, 1082, 1709, 1799, 1929, 2651, 2832, 2918], 'βG-spectrin,': [485], 'dynamin,': [487], 'PLCδ1': [489, 646, 794, 1229, 1346, 1409, 1426, 1460, 1539, 1546, 1623, 1635, 2284, 2338, 2547, 2667, 2732, 2840, 3345], 'very': [491, 1010, 2169, 2240], 'similar': [492, 3056, 3127, 3287], '(5Ferguson': [493, 2558, 2694, 2742], 'K.M': [494, 514, 618, 1247, 1293, 2559, 2695, 2715, 2743], 'Lemmon': [495, 515, 619, 2560, 2696, 2716, 2744], 'M.A': [496, 516, 620, 1245, 1291, 2561, 2697, 2717, 2745], 'Schlessinger': [497, 519, 623, 1250, 1296, 1848, 2562, 2698, 2720, 2746], 'J': [498, 520, 624, 985, 1251, 1297, 1849, 2563, 2699, 2721, 2747, 3074], 'Sigler': [499, 517, 621, 1248, 1294, 2564, 2700, 2718, 2748], 'P.B': [500, 518, 622, 1249, 1295, 2565, 2701, 2719, 2749], '83:': [503, 2568, 2704, 2752], '1037-1046Abstract': [504, 2569, 2705, 2753], '(531)': [510, 2575, 2711, 2759], '6Ferguson': [513, 2714], 'Nature': [521, 625, 2722], 'Struct.Biol.': [522, 626, 2723], '2:': [524, 628, 2725], '715-718Google': [525, 629, 2726], 'Scholarreferences': [526, 1958], 'therein).': [527, 1959], 'Each': [528, 585, 2061, 3002], 'sandwich': [533, 559, 2079], 'formed': [534], 'two': [536, 954, 1787, 1804, 2063, 2246, 2618, 3161], 'nearly': [537, 2064], 'orthogonal': [538, 2065], 'antiparallel': [539, 2066], 'sheets': [541, 2068, 3368], '4': [543, 2070, 2586], '3': [545, 2072, 2693, 2741, 2795, 2897], 'strands': [546], 'respectively.': [547], 'An': [548], 'amphipathic': [549, 2087, 3028], 'C-terminal': [550, 756, 905, 1809, 2088, 3027, 3051, 3062], 'α': [551, 2089, 3029, 3052], 'helix': [552, 2090, 3030, 3053], 'closes': [553], 'off': [554, 2084], 'one': [555, 2081, 2927], 'corner': [556, 2082], '(Figure': [560, 1648, 1965, 2091, 2128, 2339, 2368, 2762, 2796, 2843, 2884, 3034, 3348], '1A': [561, 2579], 'Figure': [563, 787, 2094, 2131, 2578, 2581, 2585, 2887, 3037, 3351], '1C).': [564], 'loops': [566, 595, 2678, 2690, 2737, 2792, 3374], 'strands,': [570, 2073], 'particularly': [571, 2802, 3362], 'β1/β2,': [573, 2674], 'β3/β4,': [574, 2675], 'β6/β7': [576, 2677, 2873], 'loops,': [577, 2933], 'differ': [578], 'greatly': [579], 'length': [581], 'sequence.': [584], 'electrostatically': [589], 'polarized,': [590], 'most': [593, 977, 2680, 2931], 'variable': [594, 605, 2681, 2689, 2736, 2791, 2895, 2932, 3372], 'coincide': [596], 'positively': [599, 603], 'charged': [600, 604], 'face.': [601], 'This': [602, 1369], 'may': [607, 1478, 2438, 3054, 3122], 'function': [608, 2260], 'ligand': [611, 1658, 2251, 2460, 2621, 2905], 'site': [613, 722, 871, 1465], 'for': [614, 676, 824, 973, 1423, 1524, 1550, 1621, 1824, 2308, 2474, 3170, 3184, 3215, 3252, 3340], '(6Ferguson': [617], 'Scholar).Figure': [630], '2Both': [631], 'PTB/PH': [632, 715, 864], 'Domains': [635], 'Involved': [637], 'Recruitment': [639], 'Membrane': [642], 'SurfaceShow': [643], 'full': [644], 'caption(A)': [645], 'anchored': [648, 796], 'its': [650, 657, 714, 798, 805, 863, 2383, 3209], 'membranes': [654, 802, 1049, 1486, 1639], 'substrate,': [658, 806], 'PtdIns(4,5)P2': [659, 807], '(PIP2),': [660, 808], 'permitting': [661, 809], 'processive': [662, 810], 'hydrolysis': [663, 683, 811, 831, 1532, 2336], '(high': [664, 812], 'activity).': [665, 813], 'Accumulating': [666, 814], 'InsP3': [667, 815, 1616, 2543, 2663, 2728, 2836], '(IP3),': [668, 816], 'produced': [669, 817], 'enzyme,': [672, 820], 'competes': [673, 821, 1285], 'PIP2': [675, 682, 823, 830], 'domain.': [681, 829, 2430, 2669], 'unanchored': [686, 834], 'enzyme': [687, 835, 1469, 1481, 1647], 'will': [688, 836, 3188, 3207], 'less': [690, 838], 'efficient,': [691, 839], 'requiring': [692, 840], 'dissociation': [693, 841], 'reassociation': [696, 844], '(low': [700, 848], 'activity)': [701, 849], '(see': [702, 783, 850, 932], 'text).(B)': [703], 'recruited': [706, 764, 855, 913], 'surface': [710, 782, 859, 931, 2294], 'juxtamembraneous': [719, 868], 'phosphorylation': [721, 870], 'NGFR.': [725, 874], 'phosphorylated': [728, 741, 877, 890, 2215, 3224, 3234], 'receptor.': [732, 881], 'Grb2': [737, 748, 886, 897], 'then': [738, 887], 'binds': [739, 888, 1129, 1232, 1269, 1347, 1911, 2774, 2993], 'Shc.': [742, 891, 2355], 'bound': [750, 899, 2904], 'proline-rich': [752, 901], 'regions': [753, 902, 1472, 2106, 3012], 'tail': [757, 906], 'Sos': [760, 776, 909, 925, 2381, 2394, 2435], 'itself': [761, 910], 'Grb2/Sos': [769, 918, 2364], 'recruitment': [770, 919], 'also': [771, 920, 1050, 1128, 1268, 2426], 'involves': [772, 921, 1007, 2735], 'text).View': [784], 'Large': [785], 'Image': [786], 'ViewerDownload': [788], 'Hi-res': [789], 'image': [790], 'Download': [791], '(PPT)': [792], '(A)': [793], 'text).': [851, 933], '(B)': [852], 'attempts': [935], 'made,': [938], 'without': [939], 'success,': [940], 'identify': [942], 'ligands': [944, 1620, 2288, 3169, 3183, 3219, 3304, 3309, 3332], 'using': [948], 'approaches': [949], 'yeast': [953], 'hybrid': [955], 'system': [956], 'expression': [958], 'cloning': [959], 'strategies.': [960], 'However,': [961, 2630], 'βγ': [965], 'subunits': [966], 'G-proteins': [968], '(Gβγ)': [969], 'has': [970, 1412], 'reported': [972], 'several': [974, 1214, 1832, 2253, 3253], 'notably': [978, 1080], 'βARK': [981, 1014, 1046, 1186, 3066, 3099, 3139], '(18Touhara': [982, 3071], 'K': [983, 1060, 1190, 1322, 1585, 1847, 3072, 3105], 'Inglese': [984, 3073], 'Pitcher': [986, 3075], 'J.A': [987, 1058, 1188, 3076, 3103], 'Shaw': [988, 3077], 'G': [989, 3078], 'Lefkowitz': [990, 1063, 1193, 3079, 3108], 'J.': [992, 1065, 1151, 1195, 1333, 1391, 1446, 1509, 1562, 1596, 2412, 2961, 3081, 3110], 'Biol.': [993, 1066, 1196, 1334, 1392, 1510, 1563, 1597, 1854, 3082, 3111], 'Chem.': [994, 1067, 1197, 1335, 1393, 1511, 1564, 1598, 2413, 3083, 3112], '269:': [996, 1337, 1395, 1513, 1566, 1600, 3085], '10217-10220Abstract': [997, 3086], 'Binding': [1004, 1822], 'Gβγ': [1006, 3070, 3136], 'only': [1008, 2634], 'C-terminus': [1011], 'domain,': [1016, 1025, 1382, 1625, 2386], 'together': [1017, 2583], 'outside': [1022], 'so': [1026], 'clear': [1030], 'what': [1032], 'extent': [1033], 'property': [1037], 'itself.': [1042], 'Association': [1043], 'intact': [1045, 1384], 'Gβγ-containing': [1048], 'presence': [1053], 'phosphatidylinositol(4,5)bisphosphate': [1055], '(PtdInsP2)': [1056], '(16Pitcher': [1057, 1187, 3102], 'Touhara': [1059, 1189, 3104], 'Payne': [1061, 1191, 3106], 'E.S': [1062, 1192, 3107], '270:': [1069, 1199, 2415, 3114], '11707-11710Crossref': [1070, 1200, 3115], '(328)': [1073, 1203, 3118], 'those': [1081, 3058, 3143], 'spectrin,': [1085, 2919], 'low': [1092, 1165, 2910, 3246, 3288], 'affinity': [1093, 1239, 1350, 1661, 2476, 2911, 3182, 3247, 3289], '(Kd': [1094, 1131, 1240, 1275], '≥': [1095, 1132], '30': [1096], 'μM)': [1097, 1134, 1243, 1278], 'little': [1099], 'apparent': [1100], 'stereospecificity': [1101], 'PtdInsP2': [1103, 1235, 1288, 1484, 1531, 1614, 2335], 'vesicles': [1106, 1353], '(8Harlan': [1107], 'Hajduk': [1109, 2972], 'P.J': [1110, 2973], 'Yoon': [1111, 2974], 'H.S': [1112, 2975], '371:': [1117, 2980], '168-170Crossref': [1118, 2981], '(674)': [1121, 2984], 'spectrin': [1125, 1223], 'weakly': [1130], '40': [1133], 'inositol(1,4,5)trisphosphate': [1136, 1266], '(InsP3)': [1137, 1267], '(10Hyvönen': [1138, 2948], 'Macias': [1140, 2950], 'Nilges': [1142, 2952], 'Oschkinat': [1144, 2954], 'H': [1145, 1312, 1324, 1328, 1330, 1332, 1575, 1587, 1591, 1593, 1595, 2955], 'Wilmanns': [1148, 2958], 'EMBO': [1150, 2960], '14:': [1153, 2963], '4676-4685Crossref': [1154, 2964], '(306)': [1157, 2967], 'biological': [1161], 'relevance': [1162], 'these': [1164, 1610, 2443, 3297], 'affinity,': [1166, 1873, 2233, 3166, 3329], 'rather': [1167], 'nonspecific': [1168, 1217], 'remains': [1170], 'established,': [1173], 'but': [1174], 'possible,': [1177], 'case': [1181, 2300, 2318, 2947], 'could': [1209, 3141], 'involve': [1210, 2555, 2924], 'cooperation': [1212], 'weak,': [1215], 'relatively': [1216, 1237], 'interactions.': [1218], 'By': [1219], 'contrast': [1220], 'specifically': [1233], '=': [1241, 1276], '1.7': [1242], '(12Lemmon': [1244, 1290], 'Ferguson': [1246, 1292], 'Proc.': [1252, 1298], 'Natl.': [1253, 1299], 'Acad.': [1254, 1300], 'USA.': [1256, 1302], '92:': [1258, 1304], '10472-10476Crossref': [1259, 1305], '(477)': [1262, 1308], 'D-myo': [1265], 'tightly': [1270], '0.21': [1277], 'highly': [1281], 'specific': [1282, 3180, 3211, 3216, 3230], 'manner,': [1283], 'directly': [1286], '19Yagisawa': [1311, 1574], 'Hirata': [1313, 1329, 1576, 1592], 'Kanematsu': [1315, 1578], 'Watanabe': [1317, 1580], 'Y': [1318, 1581], 'Ozaki': [1319, 1582], 'Sakuma': [1321, 1584], 'Tanaka': [1323, 1586], 'Yabuta': [1325, 1588], 'N': [1326, 1589], 'Kamata': [1327, 1590], 'Nojima': [1331, 1594], '20179-20188Abstract': [1338, 1601], 'Whole': [1345], 'PtdInsP2-containing': [1352, 1541, 3291], '(17Rebecchi': [1354, 1488], 'Peterson': [1356, 1490], 'McLaughlin': [1358, 1492], 'Biochemistry.': [1360, 1494], '1992;': [1361, 1495], '31:': [1362, 1496], '12742-12747Crossref': [1363, 1497], '(175)': [1366, 1500], 'amino-terminal': [1374], 'PLCδ1,': [1377, 1534], 'contains': [1379, 1803, 2062, 2427], '(3Cifuentes': [1385, 1556], 'M.E': [1386, 1504, 1557], 'Delaney': [1387, 1505, 1558], 'Rebecchi': [1389, 1507, 1560], '1945-1948Abstract': [1396, 1514, 1567], 'immunofluorescence': [1404], 'subcellular': [1405], 'localization': [1406], 'analysis': [1407], 'deletion': [1410], 'mutants': [1411], 'further': [1413], 'demonstrated': [1414], 'necessary': [1420], 'sufficient': [1422], 'interaction': [1424, 1551, 1675, 2912, 3130], 'plasma': [1429, 1475, 2447], '(15Paterson': [1431], 'H.F': [1432], 'Savopoulos': [1433], 'J.W': [1434], 'Perisic': [1435], 'O': [1436], 'Cheung': [1437], 'Ellis': [1439], 'M.V': [1440], 'Williams': [1441, 1682, 1883], 'R.L': [1442], 'Katan': [1443], '312:': [1448], '661-666Crossref': [1449], '(111)': [1452], 'Thus': [1455], 'represents': [1461], 'noncatalytic': [1463], 'recruits': [1467], 'PtdInsP2-rich': [1471], 'allow': [1479], 'hydrolyze': [1483], 'processively': [1487], '3Cifuentes': [1503], 'seen': [1523, 2151, 2470, 3381], 'phospholipases.': [1526], 'InsP3,': [1527], 'product': [1529, 1643], 'inhibits': [1535, 1545], 'membranes,': [1542], 'activity': [1547, 2360], 'competing': [1549], 'Taken': [1608], 'together,': [1609], 'results': [1611], 'physiologically': [1618, 3167, 3257, 3307], 'relevant': [1619, 3308], 'regulatory': [1632], 'controlling': [1634], 'targeting': [1636], 'substrate-containing': [1638], 'inhibition': [1644], '2A).': [1649], 'Very': [1650], 'recently,': [1651], 'second': [1653, 2228], 'specificity': [1663, 1928], 'identified.': [1665, 3314], 'Structure': [1666], 'phosphotyrosine': [1670, 1674, 2636, 2769], '(PTB)': [1672], '(PI)': [1676], '(11Kavanaugh': [1678, 1879], 'W.M': [1679, 1880], 'Turck': [1680, 1881], 'C.W': [1681, 1882], 'L.T': [1683, 1884], 'Science.': [1684, 1885], '268:': [1686, 1887], '1177-1179Crossref': [1687, 1888], '(223)': [1690, 1891], '2Bork': [1693], 'P': [1694, 1845], 'Margolis': [1695, 1850], 'B': [1696, 1851], '80:': [1699], '693-694Abstract': [1700], '(172)': [1706], 'Scholar)': [1708, 1742, 1769, 2539, 2761], 'adapter': [1711], '(4Eck': [1745, 1934, 2025], 'showed': [1770], 'them': [1771], 'both': [1772, 2015, 2257, 2790], 'had': [1778], 'previously': [1780], 'themselves': [1790], 'share': [1791, 2252], 'no': [1792, 2147], 'significant': [1793], 'similarity,': [1795], 'domains.': [1801, 2060, 2163, 2202, 2629, 3001], 'phosphotyrosine-recognizing': [1806], 'regions:': [1807], 'N-terminus': [1818, 1906], 'molecule.': [1821, 1909], 'sites': [1823], 'comprise': [1838], 'consensus': [1840], 'L/IXNPXpY': [1841], '(1Batzer': [1842], 'A.G': [1843], 'Blaikie': [1844], 'Nelson': [1846], 'Mol.': [1852], 'Cell': [1853], '15:': [1856], '4403-4409Crossref': [1857], '(116)': [1860], 'Synthetic': [1863], 'peptides': [1864], 'specifically,': [1869], 'adjacent': [1899], 'an': [1913, 1974, 2021, 2086], 'NPXpY-containing': [1914], 'juxtamembrane': [1919], 'insulin': [1923, 2022, 2224, 2859], 'shows': [1926], 'structure': [1964], '1)': [1966], 'determined': [1968, 2013], 'complex': [1972, 2019], 'NGF': [1975, 2221], '(TrkA)': [1977, 2222], 'phosphopeptide': [1978, 2024], 'crystallographically,': [2014], 'unliganded': [2016], 'exactly': [2054], 'topology': [2057], '(with': [2069, 3274], 'respectively)': [2074], 'form': [2076], 'closed': [2083], '1': [2092, 2123, 2691, 2793, 2800], '2': [2095, 3038], 'Eck': [2097, 2134, 2890, 3040], 'et': [2098, 2135, 2891, 3041], 'al.,': [2099, 2136, 2892, 3042], '1996).': [2100, 2137, 2893, 3043], 'backbone': [2102], 'core': [2105], 'superimposed': [2115], 'root-mean-squared': [2118], '(r.m.s.)': [2119], 'deviation': [2120], 'just': [2122, 3275], 'Å': [2124, 2127], '1.9': [2126], '1C': [2129], '8B': [2132], 'difference': [2139], 'greater': [2148], 'Thus,': [2164, 2894], 'spite': [2166], 'limited': [2170, 3300], 'similarity': [2172], 'they': [2177, 2270], 'all': [2178, 2551, 2923], 'fold.': [2182], 'From': [2183], 'standpoint,': [2186], 'therefore,': [2187], 'classified': [2197], 'bona': [2199], 'fide': [2200], 'NPXpY': [2216, 2477, 2639, 2772, 2861, 2991, 3155], 'sequences': [2217, 3232], 'receptors': [2225, 2297], 'specific,': [2231], 'biologically': [2234], 'relevant,': [2235, 3168], 'ligands.': [2238], 'Although': [2239], 'structures,': [2244], 'classes': [2247, 2456, 2619, 3163], 'common': [2254, 2275, 2452], 'characteristics': [2255], '-': [2256, 2295, 3305], 'nature': [2264], 'participate.': [2271], 'Functionally,': [2272], 'feature': [2274], 'Shc,': [2281], 'associated': [2290], 'PLCδ1.': [2309], 'each': [2317, 2907, 2946, 3200], 'target': [2321, 2453], 'facilitate': [2330], 'regulate': [2332], 'enzymatic': [2333], 'reactions:': [2334], '2A);': [2340], 'coupling': [2342], 'activation': [2345], 'downstream': [2347], 'effectors': [2348], 'cases': [2351], 'Ras': [2356, 2397, 2421], 'exchange': [2359], 'regulated': [2362], '2B)': [2369], 'IRS-1.': [2371], 'noteworthy': [2374], 'factor': [2380], 'possesses': [2382], 'own': [2384, 3210, 3327], 'elimination': [2387], 'compromises': [2390], 'ability': [2392], 'activate': [2396], '(14McCollam': [2398], 'L': [2399, 2401], 'Bonfini': [2400], 'Karlovich': [2402], 'C.A': [2403], 'Conway': [2404], 'B.R': [2405], 'Kozma': [2406], 'L.M': [2407], 'Banerjee': [2408], 'U': [2409], 'Czech': [2410], 'M.P': [2411], '15954-15957Scopus': [2416], '(72)': [2417], 'activating': [2423], 'protein,': [2424], 'Ras-Gap,': [2425], 'localizing': [2442], 'Ras.': [2454], 'Both': [2455], 'phosphorylated,': [2462], 'involving': [2465, 2633, 2783], 'phosphate': [2466, 2556, 2901], 'groups': [2467], 'clearly': [2469], 'important': [2473], '(where': [2550], 'groups)': [2557], '1B,': [2582], 'Scholar': [2612], 'show': [2613], 'that,': [2614], 'broadly': [2615], 'speaking,': [2616], 'on': [2623, 2824], 'opposite': [2624, 2831], 'sides': [2625], 'cognate': [2628], 'if': [2631, 3320], 'peptide': [2640, 2773, 2862, 2992, 3048], 'considered': [2649], 'separately': [2650], 'rest': [2653], 'peptide,': [2656], 'there': [2657], 'some': [2659], 'interesting': [2660], 'parallels': [2661], 'As': [2670], 'mentioned': [2671], 'above,': [2672], 'designated': [2688], '1,': [2738], '2,': [2739], '3A).': [2763], 'Using': [2764], 'loop': [2766, 2799, 2874, 2876, 2896], 'designation,': [2767], 'basic': [2784], 'side-chains': [2785], 'acids': [2788], '3B).': [2797, 2844], 'Variable': [2798], 'long': [2803], 'extends': [2810], 'around': [2811], 'residues': [2815, 2846], "β1'": [2817], 'α2': [2819], 'interact': [2821, 2853, 3123], 'pY': [2823, 2856], 'face': [2826], 'conserved': [2865], '(variable': [2875], '3),': [2877], 'β4/β5': [2879], 'loop,': [2880], 'strand': [2882, 3023], 'β5': [2883, 3024], '7': [2885], '9': [2888], 'interacts': [2898], 'case.': [2908], 'Similarly,': [2909], 'phosphoinositides': [2914, 3121, 3250], 'least': [2926], 'additional': [2935, 3179], 'contacts': [2936], 'being': [2937], 'made': [2938], 'portions': [2941], '8Harlan': [2970], 'remainder': [2988], 'similarly': [2994], 'forms': [3003], 'turn': [3006, 3016], 'pY,': [3010], 'N-terminal': [3013, 3151], 'fill': [3017], 'groove': [3019], 'exists': [3021], '3B': [3035], 'These': [3044], 'inferred': [3059], 'portion': [3063, 3152], 'Indeed,': [3093], 'cooperative': [3095], 'manner': [3126, 3377], 'while': [3135], 'resemble': [3142], 'peptide.': [3156], 'With': [3157], 'identification': [3159], 'distinct': [3162], 'appears': [3174, 3242], 'reasonable': [3175], 'assume': [3177], 'future.': [3193], 'clear,': [3197], 'however,': [3198], 'whether': [3199], 'proposed': [3204], 'ligand.': [3212], 'Possible': [3213], 'candidates': [3214], 'include': [3220], 'inositol': [3222], 'polyphosphates,': [3223], 'components,': [3226], 'containing': [3233], 'tyrosine,': [3235], 'serine,': [3236], 'threonine,': [3237], 'histidine': [3239], 'residues.': [3240], 'unlikely': [3243], 'described': [3251, 3339], 'relevant.': [3258], 'difficult': [3261], 'imagine': [3263], 'why': [3264], 'diverse': [3269], 'family': [3270], '10-15%': [3276], 'identity)': [3278], 'would': [3279], 'exist': [3280], 'order': [3282], 'Rather,': [3293], 'we': [3294], 'noncognate': [3303], 'yet': [3311], 'many,': [3319], 'all,': [3322], 'membrane-associated,': [3331], 'operate': [3334], 'according': [3335], 'paradigms': [3338], '2A': [3349], '2B).': [3352], 'reflect': [3360], 'stable': [3363], 'scaffold': [3365], 'ligand-binding': [3373], 'analogous': [3378], 'immunoglobulin': [3384], 'superfamily.': [3385]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2070082950', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2022, 'cited_by_count': 2}, {'year': 2021, 'cited_by_count': 5}, {'year': 2019, 'cited_by_count': 5}, {'year': 2018, 'cited_by_count': 3}, {'year': 2017, 'cited_by_count': 3}, {'year': 2016, 'cited_by_count': 6}, {'year': 2015, 'cited_by_count': 4}, {'year': 2014, 'cited_by_count': 3}, {'year': 2013, 'cited_by_count': 1}, {'year': 2012, 'cited_by_count': 6}], 'updated_date': '2024-12-16T09:11:56.293388', 'created_date': '2016-06-24'}