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'overweight,5': [280], 'remains': [281, 757, 1593], 'controversial.': [282], 'In': [283, 559, 951, 1456, 2470], 'mortality': [287, 308, 328, 433, 614, 1856, 1954, 1988, 2086, 2138, 2429, 2460], 'data': [288, 305, 1815], 'provided': [289], 'Metropolitan': [292, 1771, 1775], 'Life': [293, 1772, 1783], 'Insurance': [294, 1773], 'Company': [295], 'historically': [296], 'have': [297, 986, 1129, 1135, 1234, 1396, 1484], 'been': [298, 1095, 1269, 1387, 1397, 1575], 'used': [299], 'define': [301, 365], 'obesity.6': [302], 'Yet': [303, 389], 'these': [304, 502], 'relate': [306, 521], 'only,': [309], 'depends': [313], 'on': [314, 994, 1066, 1239, 2411, 2495, 2544, 2571, 2574, 2581, 2651, 2887, 3132, 3454, 3477, 3523, 3627, 3757, 3968], 'person’s': [316], 'frame': [317], '(size),': [318], 'which': [319, 890], 'arbitrary': [321], 'independently': [324, 540, 2524], 'related': [325, 468, 640, 662, 786, 880, 1486], 'obesity-related': [327], 'comorbidities.': [330], 'Body': [331, 1853, 2052, 2129, 2705, 3064, 3997], 'mass': [332, 649, 1241, 1824, 2130, 3416, 3719], 'index': [333, 1825, 2131, 3417, 3720], '(BMI)': [334], 'recently': [336, 452, 1096], 'gained': [337], 'favor': [338], 'better': [341], 'measure': [342], 'adiposity.78': [344], 'BMI': [345, 363, 375, 394, 517, 568, 594, 1089, 1103, 1289, 1422, 1435, 1476], 'defined': [347], 'kilograms': [351], 'divided': [352], 'height': [354, 1776], 'meters': [356], 'squared': [357], '(kg/m2).': [358], 'threshold': [360], 'level': [361], 'entirely': [369], 'appropriate': [370], 'because': [371, 1160], 'women,': [373], '<21': [376], 'greatest': [382], 'protection': [383], 'coronary': [385, 458, 473, 512, 542, 582, 609, 814, 829, 1046, 2060, 2422], 'disease': [387, 460, 475, 514, 611, 1048, 1057, 1384, 1885, 1928, 2015, 2062, 2193, 2424, 2974, 3840], 'mortality.9': [388], 'many': [391, 984], 'women': [392, 553, 565, 1900, 2786, 3295], 'near': [395], '30': [396], 'still': [398], 'concern': [402], 'when': [403, 687, 695], 'adipose': [407, 1879, 1920, 3123], 'tissue': [408, 1880, 1921, 3124], 'distributed': [410], 'pelvis': [413], 'abdomen.': [417], 'Substantial': [418], 'evidence': [419, 1123, 1691], 'now': [420], 'indicates': [421], 'increased': [424, 601, 710], 'waist': [425, 1494, 3715], 'circumference,': [426], 'waist-to-hip': [428], 'ratio,': [429], 'predicts': [430, 541], 'obesity.1011': [435], 'Unfortunately,': [436], 'BMI-based': [438], 'fails': [440], 'take': [442], 'body': [443, 523, 1013, 1240, 1488, 1760, 1823, 2008, 2133, 2792, 3415, 3718], 'distribution': [445, 2056], 'into': [446], 'account.Obesity': [447], 'Coronary': [449], 'DiseaseUntil': [451], 'relation': [454, 545, 605, 2232, 2596], 'between': [455, 606, 1104, 1375, 3070], 'was': [461, 804, 1613], 'viewed': [462], 'indirect,': [464], 'ie,': [465, 1511], 'through': [466], 'covariates': [467], 'risk,12': [476], 'hypertension;': [478], 'dyslipidemia,': [479, 1078], 'particularly': [480, 1603], 'reductions': [481, 941], 'HDL': [483], 'cholesterol;': [484], 'impaired': [486], 'glucose': [487], 'tolerance': [488], 'non–insulin-dependent': [490, 975, 1025], 'diabetes': [491, 1026, 2110, 2464], 'mellitus.': [492, 2111, 2465], 'Insulin': [493], 'resistance': [494, 1974], 'accompanying': [496], 'hyperinsulinemia': [497], 'typically': [499, 1419], 'comorbidities.13': [503], 'relating': [509], 'artery': [513, 610], 'increases,': [518, 689], 'they': [519], 'distribution.': [525, 1490], 'Long-term': [526, 2894, 2989, 3021], 'longitudinal': [527], 'studies,': [528], 'however,': [529], 'indicate': [530, 1007, 1328], 'such': [534, 867, 998, 1499], 'relates': [537], 'atherosclerosis.91415': [543], 'appears': [546, 1040], 'exist': [548], 'men': [551, 586, 1941, 1959, 1990, 2023, 2818, 3033, 3724], 'minimal': [555], 'increases': [556, 765], 'BMI.': [558], '14-year': [561], 'prospective': [562], 'study,': [563, 3851], 'middle-aged': [564, 2064], '>23': [569], '<25': [571, 1090], 'had': [572, 598, 1235, 1355], '50%': [574], 'risk': [577, 996, 1321, 1521, 1882, 1925, 2947, 3841, 3925], 'nonfatal': [579], 'fatal': [581], 'disease,9': [584], 'aged': [587], '40': [588], '65': [590], 'years': [591], '>25': [595], '<29': [597], '72%': [600], 'risk.16': [602], 'The': [603, 722, 856, 877, 1297, 1444, 2231, 2296, 2352, 2452, 2808, 3621, 3933], 'overall': [604, 2419], 'morbidity': [612], 'less': [616], 'clear': [617], 'Hispanics,17': [619], 'Pima': [620], 'Indians,18': [621], 'African-American': [623], 'women.19Congestive': [624], 'FailureLeft': [626], 'ventricular': [627, 648, 702, 748, 819, 896, 906, 916, 947, 2285], 'hypertrophy': [628, 723, 820], 'common': [630, 674, 846], 'patients': [632, 762, 795, 852, 932, 1100, 1127, 1141, 1346, 1380, 1473, 1479, 1555, 2494, 3412], 'extent': [638], 'systemic': [642, 720, 743], 'hypertension.20': [643], 'abnormalities': [645], 'left': [647, 701, 726, 747, 783, 818, 915, 2284], 'function': [651, 948, 2106], 'occur': [653, 874, 910], 'absence': [656], 'hypertension21': [658], 'severity': [665, 1068], 'obesity.22': [667], 'Hypertension': [668, 2282], 'three': [671], 'times': [672], 'obese': [676, 761, 791, 1059, 1126, 1379, 2785, 2878, 3411], 'than': [677, 1258, 1352, 2842], 'normal-weight': [678], 'persons.23': [679], 'relationship': [681], 'cause-and-effect': [684], 'so': [690], 'does': [691], 'blood': [692, 698, 2236, 2498, 2522], 'pressure,24': [693], 'whereas': [694], 'decreases,': [697], 'pressure': [699, 2237, 2499, 2523], 'falls.25Increased': [700], 'volume': [703, 712, 749, 768], 'wall': [705, 754], 'stress': [706, 755], 'addition': [708], 'stroke': [711, 767], 'cardiac': [714, 770, 840, 3133, 3793], 'output': [715, 771], 'commonly': [717, 2977], 'hypertension.2126': [721], 'ventricle': [727, 784], 'concentric': [730, 817], 'eccentric,': [732], 'diastolic': [734, 775], 'dysfunction': [735, 776, 907], 'common.': [737], 'When': [738, 793, 1168, 1433], 'present': [741], 'hypertension': [744, 893], 'absent,': [746], 'often': [751, 925], 'increased,': [752], 'usually': [756], 'normal.': [758], 'without': [763, 821], 'hypertension,': [764, 1079], 'well': [773], 'seen.': [778], 'These': [779], 'changes': [780, 2266, 2711, 2851], 'sudden': [788, 809, 849], 'death': [789, 810, 850, 2187], 'patients.': [792, 2304], '22': [794], 'severe': [797, 813, 854, 1176, 1181, 2548, 2675, 3007], 'were': [799], 'examined': [800], 'postmortem,': [801], 'dilated': [802, 835], 'cardiomyopathy': [803, 2353], 'frequently': [806], '(n=10),': [811], 'atherosclerosis': [815], '(n=6),': [816], 'dilatation': [822], '(n=4),': [823], 'pulmonary': [824, 892, 1370, 2950], 'embolism': [825], '(n=1),': [826], 'hypoplastic': [828], 'arteries': [830], '(n=1)': [831], 'found.22': [833], 'Thus,': [834, 1037, 1563], 'cardiomyopathies,': [836], 'presumably': [837], 'concomitant': [839], 'arrhythmias,': [841], 'cause': [847], 'obesity.': [855, 876, 2196, 2355, 2373, 2549, 2900, 3008], 'prolonged': [857], 'QT': [858, 1031, 2625], 'interval': [859, 1032], 'obesity27': [863], 'predispose': [865], 'arrhythmias.Changes': [868], 'right': [871, 895, 905], 'pathophysiology': [878], 'obstructive': [882, 1084], 'sleep': [883, 1085], 'apnea': [884], 'and/or': [885, 2813], 'hypoventilation': [888], 'syndrome,': [889], 'produce': [891, 1578], 'hypertrophy,': [897], 'dilatation,': [898], 'progressive': [899], 'dysfunction,': [900, 917], 'finally': [902], 'failure.2829': [903], 'can': [908, 1195], 'consequence': [913], 'failure': [921, 1052], 'develops': [923], 'biventricular.21Treatment': [926], 'Obesity': [928, 2164, 2591, 3235, 3578, 3759, 3837, 3852, 3873, 4050], 'DiseaseIn': [931], 'congestive': [934, 1050, 1075], 'failure,': [936, 1077, 1179], 'sodium': [937], 'restriction': [938, 2677, 2815], 'small': [940, 1606], 'dramatically': [945], 'improve': [946], 'oxygenation.3031': [950], 'addition,': [952], 'studies': [954, 985, 1004, 1797], 'suggest': [955], 'extensive': [959], 'follows': [963, 1016, 1034], 'gastrointestinal': [964, 1017, 1428], 'surgery': [965, 1018, 1429, 1438, 1573, 3005, 3128], 'reduces': [968, 1022, 2456], 'cardiovascular': [969, 978, 995, 1599, 1884, 1927, 3370, 3839, 3924], 'mortality32': [970], 'persons': [973], 'diabetes,': [976, 1082], 'mortality.33': [981], 'Moreover,': [982, 1518], 'although': [983], 'demonstrated': [987, 1344], 'beneficial': [989], 'effects': [990, 1308, 2152, 2540, 2680, 2726, 2809], 'factors': [997, 3926], 'hypertension253435': [1000], 'dyslipidemia,3637': [1002], 'recent': [1003], 'Sweden': [1006], 'major': [1010, 2405, 3923], 'mellitus.38': [1027], 'Shortening': [1028], 'reduction.39': [1036], 'efficacious': [1041], 'reducing': [1043], 'risks': [1044, 1485], 'potentially': [1054], 'preventing': [1055], 'patients.Treatment': [1060], 'should': [1063, 1117, 1156, 1284, 1312, 1335], 'based': [1065], 'its': [1067, 4034], 'presence': [1071], 'eg,': [1074, 1174, 1184, 1249], 'non–insulin': [1080], 'dependent': [1081, 2463], 'apnea.': [1086], 'Maintaining': [1087], 'throughout': [1091], 'adult': [1092], 'life': [1093], 'recommended.40': [1097], '25': [1105], '30,': [1107], 'lifestyle': [1108], 'modifications': [1109], 'diet': [1111, 1588, 2979], 'exercise': [1113, 1274, 2789], 'appropriate.': [1115], 'modestly': [1119], 'restricted': [1120], 'calories;': [1122], 'suggests': [1124], 'who': [1128], 'slower': [1130], 'rates': [1131], 'long-term': [1138, 1333, 1581], 'outcomes': [1139], 'undergoing': [1142], 'rapid': [1144, 1169], 'reduction.41': [1146], 'Restricting': [1147], '<30%': [1152], 'prescribed': [1159, 2978], 'low-fat': [1161, 2716], 'diets': [1162], 'promote': [1165], 'reduction.42': [1167], 'loss': [1171, 1203, 1217, 1267, 2543, 2570], 'needed,': [1173], 'biventricular': [1177], 'restriction,': [1183], '≤800': [1185], 'daily,': [1187], 'least': [1190], '0.75': [1191], 'g/kg': [1192], 'bioavailable': [1193], 'protein,': [1194], 'used.43': [1197], 'less-urgent': [1199], 'reduction,': [1201], '0.45': [1205], 'kg': [1206], '(1': [1207], 'lb)': [1208], 'per': [1209, 1227], 'week': [1210], 'reasonable.44': [1212], 'rate': [1214], 'would': [1218], 'require': [1219], 'deficit': [1222], 'about': [1224, 1306], '400': [1225], 'day.Training': [1228], 'programs': [1229, 2760], 'activity': [1233, 1592, 1714, 2869], 'variable': [1237], 'effect': [1238, 3131], 'composition.4546': [1243], 'simply': [1245], 'changing': [1246], 'daily': [1247], 'routines,': [1248], 'parking': [1250], 'farther': [1251], 'away': [1252], 'using': [1254, 3200], 'stairs': [1256], 'rather': [1257], 'elevator,': [1260], 'effective.47': [1264], 'Once': [1265], 'achieved,': [1270], 'vigorous': [1273], 'program': [1275, 2410], 'enhance': [1278], 'weight.48Pharmaceuticals': [1283], 'considered': [1286], '>30': [1290], 'less-severe': [1293], 'comorbidities.4950': [1296], 'rationale': [1298], 'use': [1300, 1329, 1334, 1530, 2911], 'discussion': [1302], 'patient': [1305], 'adverse': [1307], 'medications': [1311], 'documented': [1314], 'patient’s': [1317], 'record.': [1318], 'If': [1319], 'sufficiently': [1325], 'serious': [1326], 'antiobesity': [1331, 1413], 'drugs,': [1332], 'anticipated.': [1337], 'case-control': [1340], 'study': [1341, 1898, 1939, 3396], 'Europe': [1343, 3846], 'treated': [1347], 'dexfenfluramine': [1349, 1395], '3': [1353], 'months': [1354, 2854], 'odds': [1357], 'ratio': [1358], '23.1': [1360], '(95%': [1361], 'confidence': [1362], 'interval,': [1363], '6.9': [1364], '77.7)': [1366], 'primary': [1369, 2949], 'hypertension.51': [1371], 'potential': [1373], 'link': [1374], 'fenfluramine': [1376, 1393], 'therapy': [1377], 'valvular': [1382], 'raised.52': [1388], 'As': [1389], 'result,': [1391], 'withdrawn': [1398], 'market.': [1401], 'Few': [1402], 'drug': [1403], 'choices': [1404], 'remain.': [1405], 'Like': [1406], 'other': [1407, 1506], 'nonsurgical': [1408], 'therapies': [1409], 'once': [1412], 'drugs': [1414, 2944], 'discontinued,': [1416], 'gain': [1418], 'follows.53When': [1420], '>35': [1424], 'exist,': [1427], 'becomes': [1430], 'consideration.': [1432], '>40,': [1437], 'treatment': [1441, 2668, 3025, 3196], 'choice.': [1443], 'experience': [1445], 'surgeon': [1448], 'type': [1450], 'operation': [1452, 2455], 'chosen': [1453], 'predict': [1454], 'outcome.': [1455], 'general,': [1457], 'Roux-en-Y': [1459], 'gastric': [1460, 1465, 2453], 'bypass': [1461, 2454], 'superior': [1463], 'plication.54Although': [1466], 'recommended': [1471], '<25,': [1477], 'category': [1482], 'clearly': [1483], 'measurement': [1492, 1801], 'circumference': [1495, 3716], 'help': [1497], 'identify': [1498], 'patients,': [1500], 'assessment': [1502], 'crude,': [1504], 'approaches': [1507, 3193], 'expensive,': [1510], 'magnetic': [1512], 'resonance': [1513], 'imaging': [1514], 'computed': [1516, 1526], 'tomography.': [1517], 'radiation': [1520], 'techniques': [1524], '(eg,': [1525], 'tomography)': [1527], 'precludes': [1528], 'their': [1529, 1557, 3130], 'children.No': [1532], 'matter': [1533], 'what': [1534], 'therapeutic': [1536, 1564], 'approach,': [1537], 'it': [1538], 'realize': [1542], 'recidivism': [1549], 'common,': [1551], '<5%': [1553], 'maintaining': [1556, 1598], '4': [1561], 'years.55': [1562], 'regimens': [1565], 'maintained': [1568], 'indefinitely;': [1569], 'even': [1570], 'then,': [1571], 'proved': [1576], 'substantial': [1579], 'sustained': [1580], 'loss.': [1583, 2630], 'Prevention': [1584, 2889], 'regular': [1590], 'highest': [1595], 'priority': [1596], 'health.': [1600], 'children': [1607, 2836], 'adolescents.“Obesity': [1609], 'Disease”': [1612], 'approved': [1614], 'Science': [1620], 'Advisory': [1621], 'Coordinating': [1623], 'August': [1626], '1997.A': [1627], 'single': [1628, 3969], 'reprint': [1629, 1653], 'available': [1631], 'calling': [1633], '800-242-8721': [1634], '(US': [1635], 'only)': [1636], 'writing': [1638], 'Association,': [1642], 'Public': [1643, 3775], 'Information,': [1644], '7272': [1645], 'Greenville': [1646], 'Avenue,': [1647], 'Dallas,': [1648], 'TX': [1649], '75231-4596.': [1650], 'Ask': [1651], '71-0130.': [1655], 'References': [1656], '1': [1657], 'Kuczmarski': [1658], 'RJ,': [1659, 1982], 'Flegal': [1660], 'KM,': [1661], 'Campbell': [1662, 2387], 'SM,': [1663, 2081], 'Johnson': [1664], 'CL.': [1665], 'Increasing': [1666], 'overweight': [1669, 2208, 2493, 2817], 'among': [1670, 1740, 1857, 1957, 2063, 3032, 3294, 3842], 'U.S.': [1671], 'adults:': [1672, 2843], 'Survey.': [1679], 'JAMA.1994;': [1680], '272:205-211.CrossrefMedlineGoogle': [1681], 'Scholar2': [1682], 'Lissner': [1683], 'L,': [1684, 1866, 1912, 1914, 2772, 2805, 2920, 3051, 3181, 3183, 3218, 3314, 3558, 3781, 3820, 3901, 4068], 'Heitmann': [1685], 'BL.': [1686], 'Dietary': [1687], 'obesity:': [1690, 1817, 2299, 2670, 3027], 'epidemiology.': [1693], 'Eur': [1694], 'J': [1695, 1725, 1751, 1766, 1832, 1861, 1962, 2034, 2070, 2091, 2113, 2169, 2305, 2326, 2346, 2433, 2466, 2528, 2632, 2655, 2685, 2738, 2796, 2954, 2983, 3010, 3037, 3187, 3283, 3748], 'Clin': [1696, 1767, 1833, 2434, 2656, 2687, 2739, 2993, 3011], 'Nutr.1995;': [1697], '49:79-90.MedlineGoogle': [1698], 'Scholar3': [1699], 'Williamson': [1700], 'DF,': [1701], 'Madans': [1702], 'J,': [1703, 2118, 2175, 2476, 2554, 2928, 3085, 3093, 3107, 3143, 3259, 3503, 3507, 3598, 3653, 3657, 3814, 3816, 3893, 3903, 3907, 3909], 'Anda': [1704], 'RF,': [1705], 'Kleinman': [1706], 'JC,': [1707], 'Kahn': [1708], 'HS,': [1709], 'Byers': [1710], 'T.': [1711], 'Recreational': [1712], 'ten-year': [1716], 'change': [1718, 2594], 'national': [1722], 'cohort.': [1723], 'Int': [1724, 2090, 2631, 2795, 3036], 'Obes.1993;': [1726], '17:279-286.MedlineGoogle': [1727], 'Scholar4': [1728], 'Popkin': [1729], 'BM,': [1730, 2445], 'Siega-Riz': [1731], 'AM,': [1732, 2830], 'Haines': [1733], 'PS.': [1734], 'comparison': [1736, 2671, 2845], 'dietary': [1738], 'trends': [1739], 'racial': [1741], 'socioeconomic': [1743], 'groups': [1744], 'States.': [1748, 2214], 'N': [1749, 1859, 2952, 2981, 3062, 3229], 'Engl': [1750, 1860, 2953, 2982], 'Med.1996;': [1752, 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