Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2069802690', 'doi': 'https://doi.org/10.1097/00004872-199206000-00001', 'title': 'Molecular biology of adrenergic receptors', 'display_name': 'Molecular biology of adrenergic receptors', 'publication_year': 1992, 'publication_date': '1992-06-01', 'ids': {'openalex': 'https://openalex.org/W2069802690', 'doi': 'https://doi.org/10.1097/00004872-199206000-00001', 'mag': '2069802690', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/1320069'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1097/00004872-199206000-00001', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S115964404', 'display_name': 'Journal of Hypertension', 'issn_l': '0263-6352', 'issn': ['0263-6352', '1473-5598'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315671', 'host_organization_name': 'Lippincott Williams & Wilkins', 'host_organization_lineage': ['https://openalex.org/P4310315671', 'https://openalex.org/P4310318547'], 'host_organization_lineage_names': ['Lippincott Williams & Wilkins', 'Wolters Kluwer'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'review', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5052177416', 'display_name': 'Ruth H. Strasser', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I223822909', 'display_name': 'Heidelberg University', 'ror': 'https://ror.org/038t36y30', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I223822909']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Ruth H. Strasser', 'raw_affiliation_strings': ['From the University of Heidelberg, Heidelberg, Germany'], 'affiliations': [{'raw_affiliation_string': 'From the University of Heidelberg, Heidelberg, Germany', 'institution_ids': ['https://openalex.org/I223822909']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5037892780', 'display_name': 'Renate Ihl-Vahl', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I223822909', 'display_name': 'Heidelberg University', 'ror': 'https://ror.org/038t36y30', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I223822909']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Renate Ihl-Vahl', 'raw_affiliation_strings': ['From the University of Heidelberg, Heidelberg, Germany'], 'affiliations': [{'raw_affiliation_string': 'From the University of Heidelberg, Heidelberg, Germany', 'institution_ids': ['https://openalex.org/I223822909']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5088359235', 'display_name': 'Rainer Marquetant', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I223822909', 'display_name': 'Heidelberg University', 'ror': 'https://ror.org/038t36y30', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I223822909']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Rainer Marquetant', 'raw_affiliation_strings': ['From the University of Heidelberg, Heidelberg, Germany'], 'affiliations': [{'raw_affiliation_string': 'From the University of Heidelberg, Heidelberg, Germany', 'institution_ids': ['https://openalex.org/I223822909']}]}], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 0.156, 'has_fulltext': False, 'cited_by_count': 12, 'citation_normalized_percentile': {'value': 0.305603, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 80, 'max': 81}, 'biblio': {'volume': '10', 'issue': '6', 'first_page': '501', 'last_page': '506'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11178', 'display_name': 'Structure and Function of G Protein-Coupled Receptors', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11178', 'display_name': 'Structure and Function of G Protein-Coupled Receptors', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T13338', 'display_name': 'Effects of Beta-Adrenergic Agonists in Livestock', 'score': 0.9989, 'subfield': {'id': 'https://openalex.org/subfields/1103', 'display_name': 'Animal Science and Zoology'}, 'field': {'id': 'https://openalex.org/fields/11', 'display_name': 'Agricultural and Biological Sciences'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10814', 'display_name': 'Role of Neuropeptides in Physiology and Disease', 'score': 0.9984, 'subfield': {'id': 'https://openalex.org/subfields/2804', 'display_name': 'Cellular and Molecular Neuroscience'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/class-c-gpcr', 'display_name': 'Class C GPCR', 'score': 0.64986074}, {'id': 'https://openalex.org/keywords/rhodopsin-like-receptors', 'display_name': 'Rhodopsin-like receptors', 'score': 0.64413244}, {'id': 'https://openalex.org/keywords/g-protein-coupled-receptors', 'display_name': 'G Protein-Coupled Receptors', 'score': 0.544275}, {'id': 'https://openalex.org/keywords/receptor-activation', 'display_name': 'Receptor Activation', 'score': 0.509167}, {'id': 'https://openalex.org/keywords/receptors', 'display_name': 'Receptors', 'score': 0.502913}, {'id': 'https://openalex.org/keywords/alpha-1a-adrenergic-receptor', 'display_name': 'Alpha-1A adrenergic receptor', 'score': 0.47905907}, {'id': 'https://openalex.org/keywords/alpha-1b-adrenergic-receptor', 'display_name': 'Alpha-1B adrenergic receptor', 'score': 0.46251145}, {'id': 'https://openalex.org/keywords/immune-receptor', 'display_name': 'Immune receptor', 'score': 0.45417333}], 'concepts': [{'id': 'https://openalex.org/C170493617', 'wikidata': 'https://www.wikidata.org/wiki/Q208467', 'display_name': 'Receptor', 'level': 2, 'score': 0.88764787}, {'id': 'https://openalex.org/C203270574', 'wikidata': 'https://www.wikidata.org/wiki/Q24725121', 'display_name': 'Class C GPCR', 'level': 5, 'score': 0.64986074}, {'id': 'https://openalex.org/C42221972', 'wikidata': 'https://www.wikidata.org/wiki/Q7321217', 'display_name': 'Rhodopsin-like receptors', 'level': 5, 'score': 0.64413244}, {'id': 'https://openalex.org/C40465926', 'wikidata': 'https://www.wikidata.org/wiki/Q410568', 'display_name': 'Adrenergic receptor', 'level': 3, 'score': 0.6208059}, {'id': 'https://openalex.org/C135285700', 'wikidata': 'https://www.wikidata.org/wiki/Q38173', 'display_name': 'G protein-coupled receptor', 'level': 3, 'score': 0.49379715}, {'id': 'https://openalex.org/C121528942', 'wikidata': 'https://www.wikidata.org/wiki/Q17710494', 'display_name': 'Alpha-1A adrenergic receptor', 'level': 5, 'score': 0.47905907}, {'id': 'https://openalex.org/C46688247', 'wikidata': 'https://www.wikidata.org/wiki/Q17710475', 'display_name': 'Alpha-1B adrenergic receptor', 'level': 5, 'score': 0.46251145}, {'id': 'https://openalex.org/C103474210', 'wikidata': 'https://www.wikidata.org/wiki/Q142851', 'display_name': 'Immune receptor', 'level': 3, 'score': 0.45417333}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.4404902}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.38977018}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.37040442}, {'id': 'https://openalex.org/C169760540', 'wikidata': 'https://www.wikidata.org/wiki/Q207011', 'display_name': 'Neuroscience', 'level': 1, 'score': 0.33251482}, {'id': 'https://openalex.org/C26702167', 'wikidata': 'https://www.wikidata.org/wiki/Q901988', 'display_name': 'Metabotropic receptor', 'level': 4, 'score': 0.2702667}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.25649086}, {'id': 'https://openalex.org/C169331234', 'wikidata': 'https://www.wikidata.org/wiki/Q4897175', 'display_name': 'Beta-3 adrenergic receptor', 'level': 4, 'score': 0.21533364}, {'id': 'https://openalex.org/C2778938600', 'wikidata': 'https://www.wikidata.org/wiki/Q389934', 'display_name': 'Agonist', 'level': 3, 'score': 0.15650457}], 'mesh': [{'descriptor_ui': 'D011941', 'descriptor_name': 'Receptors, Adrenergic', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019204', 'descriptor_name': 'GTP-Binding Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019204', 'descriptor_name': 'GTP-Binding Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011941', 'descriptor_name': 'Receptors, Adrenergic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011941', 'descriptor_name': 'Receptors, Adrenergic', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D011941', 'descriptor_name': 'Receptors, Adrenergic', 'qualifier_ui': 'Q000145', 'qualifier_name': 'classification', 'is_major_topic': False}, {'descriptor_ui': 'D011941', 'descriptor_name': 'Receptors, Adrenergic', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D011942', 'descriptor_name': 'Receptors, Adrenergic, alpha', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011942', 'descriptor_name': 'Receptors, Adrenergic, alpha', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D011942', 'descriptor_name': 'Receptors, Adrenergic, alpha', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D011942', 'descriptor_name': 'Receptors, Adrenergic, alpha', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D011942', 'descriptor_name': 'Receptors, Adrenergic, alpha', 'qualifier_ui': 'Q000145', 'qualifier_name': 'classification', 'is_major_topic': False}, {'descriptor_ui': 'D011943', 'descriptor_name': 'Receptors, Adrenergic, beta', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011943', 'descriptor_name': 'Receptors, Adrenergic, beta', 'qualifier_ui': 'Q000145', 'qualifier_name': 'classification', 'is_major_topic': False}, {'descriptor_ui': 'D011943', 'descriptor_name': 'Receptors, Adrenergic, beta', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D011943', 'descriptor_name': 'Receptors, Adrenergic, beta', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D011943', 'descriptor_name': 'Receptors, Adrenergic, beta', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1097/00004872-199206000-00001', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S115964404', 'display_name': 'Journal of Hypertension', 'issn_l': '0263-6352', 'issn': ['0263-6352', '1473-5598'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315671', 'host_organization_name': 'Lippincott Williams & Wilkins', 'host_organization_lineage': ['https://openalex.org/P4310315671', 'https://openalex.org/P4310318547'], 'host_organization_lineage_names': ['Lippincott Williams & Wilkins', 'Wolters Kluwer'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/1320069', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'score': 0.66, 'id': 'https://metadata.un.org/sdg/3', 'display_name': 'Good health and well-being'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 100, 'referenced_works': ['https://openalex.org/W109691321', 'https://openalex.org/W1482398833', 'https://openalex.org/W1488128956', 'https://openalex.org/W1496068612', 'https://openalex.org/W1507509794', 'https://openalex.org/W1517863220', 'https://openalex.org/W1520083061', 'https://openalex.org/W1524561975', 'https://openalex.org/W1527877656', 'https://openalex.org/W1528193286', 'https://openalex.org/W1528867517', 'https://openalex.org/W1530935792', 'https://openalex.org/W1533437922', 'https://openalex.org/W1533947687', 'https://openalex.org/W1559238179', 'https://openalex.org/W1559810631', 'https://openalex.org/W1568073470', 'https://openalex.org/W1574183181', 'https://openalex.org/W1579580511', 'https://openalex.org/W1580970296', 'https://openalex.org/W1582928646', 'https://openalex.org/W1586068082', 'https://openalex.org/W1588194000', 'https://openalex.org/W1603768470', 'https://openalex.org/W1665636669', 'https://openalex.org/W1765712819', 'https://openalex.org/W1794062514', 'https://openalex.org/W1841809633', 'https://openalex.org/W1865252654', 'https://openalex.org/W1935133508', 'https://openalex.org/W1940252732', 'https://openalex.org/W1966043663', 'https://openalex.org/W1971251151', 'https://openalex.org/W1983908525', 'https://openalex.org/W1985820664', 'https://openalex.org/W1991167830', 'https://openalex.org/W1991194283', 'https://openalex.org/W1991296020', 'https://openalex.org/W1993301425', 'https://openalex.org/W1996972993', 'https://openalex.org/W2001692359', 'https://openalex.org/W2001884742', 'https://openalex.org/W2002733371', 'https://openalex.org/W2002896923', 'https://openalex.org/W2006836217', 'https://openalex.org/W2006875910', 'https://openalex.org/W2006913937', 'https://openalex.org/W2007003323', 'https://openalex.org/W2009133356', 'https://openalex.org/W2012335673', 'https://openalex.org/W2012901328', 'https://openalex.org/W2014740637', 'https://openalex.org/W2015912619', 'https://openalex.org/W2018823973', 'https://openalex.org/W2024040954', 'https://openalex.org/W2026399791', 'https://openalex.org/W2029313038', 'https://openalex.org/W2033653650', 'https://openalex.org/W2036339488', 'https://openalex.org/W2038240048', 'https://openalex.org/W2045060141', 'https://openalex.org/W2045384414', 'https://openalex.org/W2045417541', 'https://openalex.org/W2047347345', 'https://openalex.org/W2047896617', 'https://openalex.org/W2048669565', 'https://openalex.org/W2049473805', 'https://openalex.org/W2052325698', 'https://openalex.org/W2056403651', 'https://openalex.org/W2056720873', 'https://openalex.org/W2067153967', 'https://openalex.org/W2067660894', 'https://openalex.org/W2073102622', 'https://openalex.org/W2075491849', 'https://openalex.org/W2080082237', 'https://openalex.org/W2080288217', 'https://openalex.org/W2080875376', 'https://openalex.org/W2082058674', 'https://openalex.org/W2092964019', 'https://openalex.org/W2101228796', 'https://openalex.org/W2116881916', 'https://openalex.org/W2116949924', 'https://openalex.org/W2124186179', 'https://openalex.org/W2136189765', 'https://openalex.org/W2147456943', 'https://openalex.org/W2157644893', 'https://openalex.org/W2164097764', 'https://openalex.org/W2168679726', 'https://openalex.org/W2174098483', 'https://openalex.org/W2219941561', 'https://openalex.org/W2263286898', 'https://openalex.org/W2264160417', 'https://openalex.org/W2281938476', 'https://openalex.org/W2284144531', 'https://openalex.org/W2414578283', 'https://openalex.org/W2415253841', 'https://openalex.org/W2419241215', 'https://openalex.org/W2441899978', 'https://openalex.org/W2460995248', 'https://openalex.org/W2468278975'], 'related_works': ['https://openalex.org/W4211003194', 'https://openalex.org/W3042775', 'https://openalex.org/W2985048223', 'https://openalex.org/W2073775600', 'https://openalex.org/W2046232255', 'https://openalex.org/W2021865527', 'https://openalex.org/W2002943506', 'https://openalex.org/W1990756371', 'https://openalex.org/W164102396', 'https://openalex.org/W1593083013'], 'abstract_inverted_index': {'G': [0, 90], 'protein-coupled': [1, 91], 'receptors': [2, 14, 30, 96], 'respond': [3], 'to': [4, 39], 'many': [5], 'neuro-': [6], 'and': [7, 33, 42, 55], 'autocrine': [8], 'transmitters.': [9], 'Among': [10], 'these': [11, 29, 95], 'receptors,': [12, 92], 'adrenergic': [13], 'are': [15, 31], 'particularly': [16], 'important': [17], 'in': [18, 87], 'the': [19, 50], 'regulation': [20], 'of': [21, 100], 'cardiovascular': [22], 'function.': [23], 'The': [24], 'primary': [25], 'physiological': [26], 'agonists': [27], 'for': [28], 'epinephrine': [32], 'norepinephrine,': [34], 'which': [35, 81], 'have': [36, 60, 74, 82], 'been': [37, 61, 75], 'used': [38], 'differentiate': [40], 'α-': [41], 's-receptor': [43], 'families': [44], '[1].': [45], 'Pharmacological': [46], 'properties': [47], 'can': [48], 'distinguish': [49], 'subtypes': [51, 73], 'α1-,': [52], 'α2-,': [53], 's1-': [54], 's2-receptors': [56], '[2,3].': [57], 'Further': [58], 'subdivisions': [59], 'made': [62], 'possible': [63], 'by': [64, 77], 'radioligand': [65], 'binding': [66], 'techniques': [67], '(e.g.': [68], 'α2A-,': [69], 'α2B-,': [70], 'α2C-receptors).': [71], 'Additional': [72], 'characterized': [76], 'molecular': [78], 'biology': [79], 'techniques,': [80], 'also': [83], 'revealed': [84], 'common': [85], 'features': [86], 'quite': [88], 'different': [89], 'suggesting': [93], 'that': [94], 'might': [97], 'be': [98], 'members': [99], 'a': [101], 'large': [102], 'receptor': [103], 'superfamily.': [104]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2069802690', 'counts_by_year': [{'year': 2021, 'cited_by_count': 1}, {'year': 2019, 'cited_by_count': 1}, {'year': 2013, 'cited_by_count': 1}], 'updated_date': '2024-08-15T08:08:23.156151', 'created_date': '2016-06-24'}