Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2069685902', 'doi': 'https://doi.org/10.1097/cad.0b013e3283405801', 'title': 'NCPMF-60 induces G2/M cell cycle arrest and apoptosis in human hepatocellular carcinoma HepG2 cells', 'display_name': 'NCPMF-60 induces G2/M cell cycle arrest and apoptosis in human hepatocellular carcinoma HepG2 cells', 'publication_year': 2010, 'publication_date': '2010-10-14', 'ids': {'openalex': 'https://openalex.org/W2069685902', 'doi': 'https://doi.org/10.1097/cad.0b013e3283405801', 'mag': '2069685902', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/20948430'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1097/cad.0b013e3283405801', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S158028025', 'display_name': 'Anti-Cancer Drugs', 'issn_l': '0959-4973', 'issn': ['0959-4973', '1473-5741'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315671', 'host_organization_name': 'Lippincott Williams & Wilkins', 'host_organization_lineage': ['https://openalex.org/P4310315671', 'https://openalex.org/P4310318547'], 'host_organization_lineage_names': ['Lippincott Williams & Wilkins', 'Wolters Kluwer'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5103330820', 'display_name': 'Qinsheng Dai', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Qin-Sheng Dai', 'raw_affiliation_strings': ['Jiangsu Key Laboratory of Carcinogenesis and Intervention'], 'affiliations': [{'raw_affiliation_string': 'Jiangsu Key Laboratory of Carcinogenesis and Intervention', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100431833', 'display_name': 'Wei Liu', 'orcid': 'https://orcid.org/0000-0002-5925-3059'}, 'institutions': [{'id': 'https://openalex.org/I83519826', 'display_name': 'Nanjing Medical University', 'ror': 'https://ror.org/059gcgy73', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I83519826']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Wei Liu', 'raw_affiliation_strings': ["Department of Pharmacology, Nanjing Medical University, Nanjing, People's Republic of China"], 'affiliations': [{'raw_affiliation_string': "Department of Pharmacology, Nanjing Medical University, Nanjing, People's Republic of China", 'institution_ids': ['https://openalex.org/I83519826']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100625049', 'display_name': 'Xiaobing Wang', 'orcid': 'https://orcid.org/0000-0001-5044-3721'}, 'institutions': [{'id': 'https://openalex.org/I161716053', 'display_name': 'China Pharmaceutical University', 'ror': 'https://ror.org/01sfm2718', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I161716053']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Xiao-Bing Wang', 'raw_affiliation_strings': ['Department of Natural Medicinal Chemistry, China Pharmaceutical University'], 'affiliations': [{'raw_affiliation_string': 'Department of Natural Medicinal Chemistry, China Pharmaceutical University', 'institution_ids': ['https://openalex.org/I161716053']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5031924605', 'display_name': 'Na Lu', 'orcid': 'https://orcid.org/0000-0002-4981-5281'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Na Lu', 'raw_affiliation_strings': ['Jiangsu Key Laboratory of Carcinogenesis and Intervention'], 'affiliations': [{'raw_affiliation_string': 'Jiangsu Key Laboratory of Carcinogenesis and Intervention', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5084313380', 'display_name': 'Dandan Gong', 'orcid': 'https://orcid.org/0000-0002-7242-8589'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Dan-Dan Gong', 'raw_affiliation_strings': ['Jiangsu Key Laboratory of Carcinogenesis and Intervention'], 'affiliations': [{'raw_affiliation_string': 'Jiangsu Key Laboratory of Carcinogenesis and Intervention', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5101537258', 'display_name': 'Ling‐Yi Kong', 'orcid': 'https://orcid.org/0000-0002-4791-8615'}, 'institutions': [{'id': 'https://openalex.org/I161716053', 'display_name': 'China Pharmaceutical University', 'ror': 'https://ror.org/01sfm2718', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I161716053']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Ling-Yi Kong', 'raw_affiliation_strings': ['Department of Natural Medicinal Chemistry, China Pharmaceutical University'], 'affiliations': [{'raw_affiliation_string': 'Department of Natural Medicinal Chemistry, China Pharmaceutical University', 'institution_ids': ['https://openalex.org/I161716053']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5083151551', 'display_name': 'Qinglong Guo', 'orcid': 'https://orcid.org/0000-0001-5165-2592'}, 'institutions': [{'id': 'https://openalex.org/I161716053', 'display_name': 'China Pharmaceutical University', 'ror': 'https://ror.org/01sfm2718', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I161716053']}], 'countries': ['CN'], 'is_corresponding': True, 'raw_author_name': 'Qing-Long Guo', 'raw_affiliation_strings': ['Jiangsu Key Laboratory of Carcinogenesis and Intervention', 'e-mail: [email\xa0protected]', "to Dr Qing-Long Guo, Jiangsu Key Laboratory of Carcinogenesis and Intervention, China Pharmaceutical University, 24 Tongjiaxiang, Nanjing, Jiangsu 210009, People's Republic of China Tel/fax: +86 25 83271055"], 'affiliations': [{'raw_affiliation_string': 'e-mail: [email\xa0protected]', 'institution_ids': []}, {'raw_affiliation_string': "to Dr Qing-Long Guo, Jiangsu Key Laboratory of Carcinogenesis and Intervention, China Pharmaceutical University, 24 Tongjiaxiang, Nanjing, Jiangsu 210009, People's Republic of China Tel/fax: +86 25 83271055", 'institution_ids': ['https://openalex.org/I161716053']}, {'raw_affiliation_string': 'Jiangsu Key Laboratory of Carcinogenesis and Intervention', 'institution_ids': []}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 2, 'corresponding_author_ids': ['https://openalex.org/A5083151551'], 'corresponding_institution_ids': ['https://openalex.org/I161716053'], 'apc_list': None, 'apc_paid': None, 'fwci': 0.338, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 16, 'citation_normalized_percentile': {'value': 0.723856, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 87, 'max': 88}, 'biblio': {'volume': '22', 'issue': '1', 'first_page': '46', 'last_page': '57'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10583', 'display_name': 'The p53 Signaling Network in Cancer Research', 'score': 0.9996, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10583', 'display_name': 'The p53 Signaling Network in Cancer Research', 'score': 0.9996, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11041', 'display_name': 'Ubiquitin-Proteasome Proteolytic Pathway', 'score': 0.9959, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11482', 'display_name': 'RNA Methylation and Modification in Gene Expression', 'score': 0.9949, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/cyclin-b1', 'display_name': 'Cyclin B1', 'score': 0.810946}, {'id': 'https://openalex.org/keywords/cell-cycle', 'display_name': 'Cell Cycle', 'score': 0.526669}, {'id': 'https://openalex.org/keywords/apoptosis', 'display_name': 'Apoptosis', 'score': 0.505723}, {'id': 'https://openalex.org/keywords/cyclin-a', 'display_name': 'Cyclin A', 'score': 0.4883537}], 'concepts': [{'id': 'https://openalex.org/C127561419', 'wikidata': 'https://www.wikidata.org/wiki/Q224527', 'display_name': 'Downregulation and upregulation', 'level': 3, 'score': 0.81755924}, {'id': 'https://openalex.org/C120504264', 'wikidata': 'https://www.wikidata.org/wiki/Q1147372', 'display_name': 'Cyclin-dependent kinase 1', 'level': 4, 'score': 0.81368905}, {'id': 'https://openalex.org/C2778437423', 'wikidata': 'https://www.wikidata.org/wiki/Q5198265', 'display_name': 'Cyclin B1', 'level': 5, 'score': 0.810946}, {'id': 'https://openalex.org/C190283241', 'wikidata': 'https://www.wikidata.org/wiki/Q14599311', 'display_name': 'Apoptosis', 'level': 2, 'score': 0.685038}, {'id': 'https://openalex.org/C105696609', 'wikidata': 'https://www.wikidata.org/wiki/Q1068809', 'display_name': 'Cell cycle checkpoint', 'level': 4, 'score': 0.6153567}, {'id': 'https://openalex.org/C29537977', 'wikidata': 'https://www.wikidata.org/wiki/Q188941', 'display_name': 'Cell cycle', 'level': 3, 'score': 0.59439194}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.5308417}, {'id': 'https://openalex.org/C154317977', 'wikidata': 'https://www.wikidata.org/wiki/Q376266', 'display_name': 'Cytotoxic T cell', 'level': 3, 'score': 0.52737784}, {'id': 'https://openalex.org/C16438837', 'wikidata': 'https://www.wikidata.org/wiki/Q5198260', 'display_name': 'Cyclin A', 'level': 5, 'score': 0.4883537}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.4102804}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.39204746}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.3869417}, {'id': 'https://openalex.org/C153911025', 'wikidata': 'https://www.wikidata.org/wiki/Q7202', 'display_name': 'Molecular biology', 'level': 1, 'score': 0.3834616}, {'id': 'https://openalex.org/C120089663', 'wikidata': 'https://www.wikidata.org/wiki/Q59250999', 'display_name': 'Cyclin', 'level': 4, 'score': 0.320594}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.11375028}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.07776332}, {'id': 'https://openalex.org/C202751555', 'wikidata': 'https://www.wikidata.org/wiki/Q221681', 'display_name': 'In vitro', 'level': 2, 'score': 0.06732792}], 'mesh': [{'descriptor_ui': 'D000970', 'descriptor_name': 'Antineoplastic Agents', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D017209', 'descriptor_name': 'Apoptosis', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': True}, {'descriptor_ui': 'D006528', 'descriptor_name': 'Carcinoma, Hepatocellular', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': True}, {'descriptor_ui': 'D002455', 'descriptor_name': 'Cell Division', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': True}, {'descriptor_ui': 'D005419', 'descriptor_name': 'Flavonoids', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D016195', 'descriptor_name': 'G2 Phase', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': True}, {'descriptor_ui': 'D008113', 'descriptor_name': 'Liver Neoplasms', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': True}, {'descriptor_ui': 'D000970', 'descriptor_name': 'Antineoplastic Agents', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017209', 'descriptor_name': 'Apoptosis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016203', 'descriptor_name': 'CDC2 Protein Kinase', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D016203', 'descriptor_name': 'CDC2 Protein Kinase', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016203', 'descriptor_name': 'CDC2 Protein Kinase', 'qualifier_ui': 'Q000037', 'qualifier_name': 'antagonists & inhibitors', 'is_major_topic': False}, {'descriptor_ui': 'D006528', 'descriptor_name': 'Carcinoma, Hepatocellular', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006528', 'descriptor_name': 'Carcinoma, Hepatocellular', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D006528', 'descriptor_name': 'Carcinoma, Hepatocellular', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D018797', 'descriptor_name': 'Cell Cycle Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018797', 'descriptor_name': 'Cell Cycle Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D002455', 'descriptor_name': 'Cell Division', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019926', 'descriptor_name': 'Cyclin B', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D019926', 'descriptor_name': 'Cyclin B', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019926', 'descriptor_name': 'Cyclin B', 'qualifier_ui': 'Q000037', 'qualifier_name': 'antagonists & inhibitors', 'is_major_topic': False}, {'descriptor_ui': 'D050759', 'descriptor_name': 'Cyclin-Dependent Kinase Inhibitor p21', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D050759', 'descriptor_name': 'Cyclin-Dependent Kinase Inhibitor p21', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005419', 'descriptor_name': 'Flavonoids', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016195', 'descriptor_name': 'G2 Phase', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020662', 'descriptor_name': 'Guanine Nucleotide Exchange Factors', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D020662', 'descriptor_name': 'Guanine Nucleotide Exchange Factors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D056945', 'descriptor_name': 'Hep G2 Cells', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008113', 'descriptor_name': 'Liver Neoplasms', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008113', 'descriptor_name': 'Liver Neoplasms', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D008113', 'descriptor_name': 'Liver Neoplasms', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D009687', 'descriptor_name': 'Nuclear Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009687', 'descriptor_name': 'Nuclear Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D019253', 'descriptor_name': 'Proto-Oncogene Proteins c-bcl-2', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019253', 'descriptor_name': 'Proto-Oncogene Proteins c-bcl-2', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D051736', 'descriptor_name': 'Proto-Oncogene Proteins c-mdm2', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051736', 'descriptor_name': 'Proto-Oncogene Proteins c-mdm2', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D016159', 'descriptor_name': 'Tumor Suppressor Protein p53', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016159', 'descriptor_name': 'Tumor Suppressor Protein p53', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1097/cad.0b013e3283405801', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S158028025', 'display_name': 'Anti-Cancer Drugs', 'issn_l': '0959-4973', 'issn': ['0959-4973', '1473-5741'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315671', 'host_organization_name': 'Lippincott Williams & Wilkins', 'host_organization_lineage': ['https://openalex.org/P4310315671', 'https://openalex.org/P4310318547'], 'host_organization_lineage_names': ['Lippincott Williams & Wilkins', 'Wolters Kluwer'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/20948430', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/3', 'score': 0.63, 'display_name': 'Good health and well-being'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 24, 'referenced_works': ['https://openalex.org/W1493893483', 'https://openalex.org/W1520797890', 'https://openalex.org/W1967880683', 'https://openalex.org/W1977497204', 'https://openalex.org/W1988050012', 'https://openalex.org/W1998187004', 'https://openalex.org/W2001872187', 'https://openalex.org/W2002936090', 'https://openalex.org/W2021092136', 'https://openalex.org/W2021505095', 'https://openalex.org/W2023623233', 'https://openalex.org/W2034059961', 'https://openalex.org/W2044704490', 'https://openalex.org/W2049901047', 'https://openalex.org/W2060513486', 'https://openalex.org/W2073810398', 'https://openalex.org/W2080204564', 'https://openalex.org/W2091345050', 'https://openalex.org/W2091414184', 'https://openalex.org/W2091766574', 'https://openalex.org/W2100963721', 'https://openalex.org/W2113868312', 'https://openalex.org/W2123940686', 'https://openalex.org/W2161158382'], 'related_works': ['https://openalex.org/W77678165', 'https://openalex.org/W3127664968', 'https://openalex.org/W2908283679', 'https://openalex.org/W257022988', 'https://openalex.org/W2113993278', 'https://openalex.org/W2062464324', 'https://openalex.org/W2032772755', 'https://openalex.org/W2017808300', 'https://openalex.org/W1997643531', 'https://openalex.org/W1982298196'], 'abstract_inverted_index': {'We': [0, 117], 'recently': [1], 'established': [2], 'that': [3, 32, 120, 184, 210], 'NCPMF-60,': [4, 52], 'a': [5], 'newly': [6], 'synthesized': [7], 'flavonoid,': [8], 'is': [9, 164], 'an': [10], 'active': [11], 'cytotoxic': [12, 22], 'component.': [13], 'The': [14, 75, 100], 'molecular': [15], 'mechanisms': [16], 'by': [17, 83, 217], 'which': [18, 112, 191], 'NCPMF-60': [19, 33, 173, 185, 218], 'exerts': [20], 'its': [21, 126, 195], 'activity': [23, 76, 233], 'are': [24], 'currently': [25], 'unknown.': [26], 'In': [27, 85], 'this': [28], 'study,': [29], 'we': [30, 87], 'show': [31, 209], 'induces': [34], 'G2/M': [35], 'phase': [36], 'arrest': [37, 200, 213], 'and': [38, 63, 70, 92, 97, 125, 144, 150, 155, 178, 201, 214, 227], 'apoptosis': [39, 202, 215], 'in': [40, 107, 111, 159, 169, 203, 234], 'human': [41], 'hepatocellular': [42], 'carcinoma': [43], 'HepG2': [44, 49, 204, 235], 'cells.': [45, 161, 205, 236], 'After': [46], 'treatment': [47, 133], 'of': [48, 77, 94, 103, 123, 134, 138, 142, 153, 172, 197, 224, 230], 'cells': [50], 'with': [51, 221], 'cell': [53, 198, 211], 'cycle-related': [54], 'proteins,': [55], 'such': [56], 'as': [57], 'cyclin': [58, 60], 'B1,': [59], 'H,': [61], 'CDK7,': [62], 'p-CDK1': [64, 71], '(Thr161),': [65], 'were': [66, 73, 157], 'downregulated,': [67], 'whereas': [68], 'p21WAF1/Cip1': [69], '(Thr14/Tyr15)': [72], 'upregulated.': [74, 116], 'CDK1/cyclinB': [78], 'complex': [79], 'was': [80, 105, 114, 219], 'also': [81, 115, 118], 'inhibited': [82], 'NCPMF-60.': [84, 135], 'addition,': [86], 'observed': [88, 158], 'poly(ADP-ribose)': [89], 'polymerase': [90], 'cleavage': [91], 'activation': [93, 223], 'caspase': [95, 98], '3': [96], '9.': [99], 'expression': [101, 122], 'ratio': [102], 'Bax/Bcl-2': [104], 'increased': [106], 'the': [108, 121, 132, 151, 166, 170, 188, 222, 228], 'treated': [109], 'cells,': [110], 'Bax': [113], 'found': [119], 'p53': [124, 163, 189, 225], 'phosphorylation': [127], 'at': [128], 'Ser15': [129], 'accumulated': [130], 'after': [131], 'Moreover,': [136], 'upregulation': [137], 'p21WAF1/Cip1,': [139], 'p53-upregulated': [140], 'modifier': [141], 'apoptosis,': [143], 'Bax,': [145], 'three': [146], 'p53-target': [147], 'gene': [148], 'products,': [149], 'downregulation': [152], 'Bcl-2': [154], 'MDM2,': [156], 'NCPMF-60-treated': [160], 'However,': [162], 'not': [165], 'only': [167], 'regulator': [168], 'stimulation': [171], 'on': [174], 'p21': [175], 'transcriptional': [176], 'level': [177], 'posttranscriptional': [179], 'level.': [180], 'These': [181], 'results': [182], 'suggested': [183], 'indeed': [186], 'activated': [187], 'pathway,': [190], 'may': [192], 'contribute': [193], 'to': [194], 'induction': [196], 'cycle': [199, 212], 'Collectively,': [206], 'our': [207], 'findings': [208], 'induced': [216], 'associated': [220], 'pathway': [226], 'inhibition': [229], 'CDK-activating': [231], 'kinase': [232]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2069685902', 'counts_by_year': [{'year': 2023, 'cited_by_count': 2}, {'year': 2020, 'cited_by_count': 5}, {'year': 2018, 'cited_by_count': 1}, {'year': 2017, 'cited_by_count': 1}, {'year': 2016, 'cited_by_count': 5}, {'year': 2013, 'cited_by_count': 1}, {'year': 2012, 'cited_by_count': 1}], 'updated_date': '2024-09-19T07:01:04.737877', 'created_date': '2016-06-24'}