Crystal Structure of Imaginal Disc Growth Factor-2

Name: Work Video:
Duration: 3 min 30 s
Paloma F. Varela; Andrea S. Llera; Roy A. Mariuzza; José R. Tormo
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237], 'with': [38, 70, 186, 238, 270, 386, 452, 476, 749, 809, 911, 937, 1134, 1194, 1374, 1473, 1520, 1555, 1585, 2146, 2331, 2439, 2561, 2585, 2632, 2760, 2798, 2966, 3100, 3118, 3560, 3690, 3716, 3775, 3838, 3891, 3988, 4217, 4256], 'insulin': [39, 198, 239, 398, 811, 821, 830, 1341], 'stimulating': [41, 241, 813], 'the': [42, 50, 61, 94, 114, 124, 166, 196, 242, 250, 261, 294, 314, 324, 366, 396, 411, 477, 598, 626, 734, 754, 819, 865, 870, 880, 928, 1178, 1195, 1203, 1269, 1305, 1311, 1319, 1323, 1333, 1340, 1381, 1415, 1560, 1639, 1676, 1682, 1690, 1695, 1715, 1804, 1826, 1849, 1871, 1893, 1902, 1913, 1935, 1960, 1987, 2034, 2056, 2065, 2076, 2104, 2139, 2183, 2251, 2268, 2426, 2440, 2443, 2469, 2495, 2500, 2534, 2545, 2668, 2757, 2799, 2805, 2836, 2886, 2899, 2923, 2943, 2951, 3082, 3085, 3397, 3452, 3465, 3470, 3535, 3588, 3640, 3648, 3691, 3707, 3710, 3717, 3783, 3816, 3825, 3828, 3831, 3909, 3926, 3933, 3936, 3941, 3984, 4002, 4011, 4015, 4022, 4029, 4038, 4045, 4064, 4134, 4138, 4151, 4164, 4171, 4223, 4227, 4237, 4471, 4484], 'cells.': [47, 247, 1353], 'We': [48, 248, 1235], 'report': [49, 249], 'crystal': [51, 251, 1501, 1631, 2141, 2255, 2273, 2374, 2497, 2524, 2746, 2789, 2811, 3917], 'structure': [52, 59, 252, 259, 1262, 1298, 1962, 2078, 2133, 2187, 2738, 2806, 3938], 'IDGF-2': [54, 101, 156, 254, 301, 356, 1160, 1185, 1238, 1457, 1488, 1504, 1625, 2135, 2435, 2540, 2740, 2897, 3494, 3641, 3792, 3937, 4036, 4095, 4115, 4231, 4477], 'at': [55, 130, 255, 330, 532, 621, 1265, 1366, 1459, 1552, 1574, 1611, 1626, 1672, 1686, 2659, 2835, 3976, 3992, 4079], '1.3-Å': [56, 256], 'resolution.': [57, 257], 'The': [58, 258, 405, 1254, 1297, 1438, 1468, 1484, 1512, 1577, 2132, 2242, 2253, 2400, 2475, 2737, 2771, 2813, 2860, 2871, 3090, 3514, 3537, 3581, 3681, 3699, 4041, 4055, 4122], 'shows': [60, 260, 3919], 'classical': [62, 262], '(βα)8': [63, 263, 1271, 2924, 3806], 'barrel-fold': [64, 264, 1275], '18': [67, 267, 860, 1278, 2904, 3441, 3523, 3798, 3993, 4440], 'glycosyl': [68, 268, 861, 1279, 2905, 3442, 3558, 3799, 4441], 'hydrolases,': [69, 269, 862, 3443], 'an': [71, 74, 271, 274, 1212, 1556, 1896, 2059, 2776, 2932, 2963, 2967, 4107], 'insertion': [72, 272, 2949, 3086], 'α': [75, 275, 1534, 1600, 1766, 1785, 2968, 3590, 3712], '+': [76, 276, 2969, 3591, 3713], 'β': [77, 277, 1536, 1602, 1768, 1787, 3592, 3714, 3811], 'domain': [78, 278, 2965, 3593, 3715], 'similar': [79, 279, 586, 1187, 1482], 'to': [80, 137, 164, 178, 280, 337, 364, 378, 449, 479, 524, 544, 555, 631, 696, 807, 858, 914, 1250, 1301, 1322, 1443, 1516, 1581, 1803, 1809, 1816, 1825, 1831, 1838, 1848, 1854, 1861, 1870, 1876, 1883, 1912, 1918, 1925, 1934, 1940, 1947, 2033, 2039, 2046, 2191, 2411, 2455, 2459, 2786, 2833, 2875, 2942, 3074, 3079, 3450, 3528, 3549, 3948, 3954, 4021, 4037, 4150, 4214, 4364], 'Serratia': [83, 283, 2150], 'marcescens': [84, 284, 2151, 2977, 3605], 'chitinases': [85, 99, 177, 285, 299, 377, 915, 1327, 2978, 4126, 4369], 'A': [86, 286, 2153, 2359, 2673, 2826, 2979, 3121, 3600, 4155], 'and': [87, 112, 287, 312, 439, 446, 584, 700, 709, 1129, 1164, 1247, 1259, 1410, 1426, 1508, 1660, 1685, 1701, 1712, 1742, 1814, 1836, 1859, 1881, 1899, 1923, 1945, 2044, 2062, 2212, 2326, 2396, 2405, 2414, 2419, 2428, 2448, 2457, 2462, 2471, 2480, 2491, 2505, 2517, 2536, 2553, 2630, 2662, 2685, 2749, 2868, 2881, 2928, 2957, 2980, 3396, 3472, 3510, 3516, 3526, 3546, 3685, 3696, 3704, 3722, 3770, 3815, 3840, 3851, 3862, 3924, 3994, 4053, 4093, 4140, 4146, 4204, 4232, 4360], 'B.': [88, 288, 884, 987, 1282, 2592, 2908, 3014, 3156, 3187, 3245, 3289, 3305, 4296], 'However,': [89, 289, 899], 'amino': [90, 290, 540, 854, 2893, 3852], 'acid': [91, 291, 541, 855, 2894, 3853], 'substitutions': [92, 292], 'consensus': [95, 295], 'catalytic': [96, 296, 904, 3471, 3842, 4228], 'sequence': [97, 297, 542, 582, 856, 912, 2895, 3431, 4016, 4046], 'give': [100, 300], 'less': [103, 303], 'negatively': [104, 304, 4147, 4219], 'charged': [105, 305, 4148, 4220], 'environment': [106, 306, 4211], 'its': [108, 308, 581, 1260, 1347], 'putative': [109, 309, 1336], 'ligand-binding': [110, 310], 'site': [111, 311, 1320, 1325, 2840, 4124], 'preclude': [113, 313], 'nucleophilic': [115, 315, 4224], 'attack': [116, 316, 4225], 'mechanism': [117, 317], 'chitin': [119, 319, 877, 946], 'hydrolysis.': [120, 320], 'Particularly': [121, 321], 'important': [122, 322, 3551], 'replacement': [125, 325, 2145, 2262], 'Glu': [127, 327, 4156], 'by': [128, 328, 443, 488, 1497, 1546, 1662, 2021, 2108, 2143, 2219, 2260, 2878, 2938, 3702, 4133], 'Gln': [129, 329], 'position': [131, 331], '132,': [132, 332], 'which': [133, 333, 619, 863, 3643, 4143], 'shown': [136, 336, 806, 2822, 4363], 'abolish': [138, 338, 4365], 'enzymatic': [139, 339, 919, 3894, 4259, 4366], 'activity': [140, 340, 455, 551, 920, 3778, 4098, 4260, 4367], 'chitinases.': [142, 342], 'Nevertheless,': [143, 343], 'modest': [145, 345], 'conservation': [146, 346], 'residues': [148, 348, 2409, 2453, 2780, 2863, 3438, 3457, 3539, 3727, 3785, 3858, 3931, 4062, 4083, 4149, 4221], 'participate': [150, 350], 'oligosaccharide': [152, 352], 'recognition': [153, 353, 1334], 'suggests': [154, 354, 3939], 'could': [157, 357], 'bind': [158, 358], 'carbohydrates,': [159, 359], 'assuming': [160, 360], 'several': [161, 361, 909, 3093], 'conformational': [162, 362], 'changes': [163, 363], 'open': [165, 365], 'partially': [167, 367, 2264], 'occluded': [168, 368], 'binding': [169, 369, 3553, 3864], 'site.': [170, 370], 'Thus,': [171, 371, 3959], 'may': [173, 373, 932, 1328, 1344, 4067], 'have': [174, 374, 456, 485, 804, 901, 921, 1175, 1236, 2541, 3108, 3955, 4085], 'evolved': [175, 375], 'from': [176, 376, 417, 492, 634, 693, 1166, 1239, 1986, 2009, 2103, 2138, 2189, 2267, 2691, 2892, 3603, 3801, 4071, 4481], 'acquire': [179, 379], 'new': [180, 380, 526, 2130], 'functions': [181, 381, 943], 'as': [182, 195, 382, 395, 702, 704, 826, 1101, 1339, 1658, 1965, 2082, 2182, 2821, 3095, 3097, 3736, 3738, 3896, 3965, 3967, 4432, 4434], 'factors,': [184, 384], 'interacting': [185, 385], 'surface': [188, 388, 3934], 'glycoproteins': [189, 389, 529], 'implicated': [190, 390], 'growth-promoting': [192, 392, 515, 550, 1349], 'processes,': [193, 393], 'such': [194, 394, 1338], 'receptor.': [199, 399], 'factor': [403, 1104], 'N-acetylglucosamine': [404], 'different': [406, 697, 2745], 'adult': [407, 706], 'epidermal': [408], 'structures': [409, 2670, 3091, 3525], 'fruit': [412], 'fly': [413], 'melanogaster': [415], 'derive': [416], 'larval': [418, 681, 698], 'sheets': [419], 'epithelial': [421], 'cells': [422, 429, 708, 1241, 1358, 1386], 'called': [423], 'are': [430, 624, 676, 729, 1733, 2436, 2526, 2817, 2873, 3518, 3635, 3644, 3728, 3793, 3833], 'dependent': [431], 'on': [432, 1351, 1698, 2667, 2809, 3932], 'soluble': [433], 'for': [436, 828, 1105, 1332, 1346, 1404, 1746, 1812, 1819, 1834, 1841, 1857, 1864, 1879, 1886, 1921, 1928, 1943, 1950, 1966, 1970, 2042, 2049, 2083, 2087, 2372, 2425, 2468, 2483, 2494, 2509, 2522, 2767, 3531, 3552, 3860, 3888, 4060, 4114, 4355], 'survival': [438], 'proliferation,': [440], 'numerous': [441], 'attempts': [442], 'homology': [444, 583, 857, 913, 3432], 'searching': [445], 'genetic': [447], 'analysis': [448, 3961], 'identify': [450], 'proteins': [451, 910, 936, 3077, 3099, 3774, 3890, 4255], 'direct': [453], 'mitogenic': [454, 758], 'unsuccessful': [458], '(1.Hipfner': [459], 'D.R.': [460], 'Cohen': [461], 'S.M.': [462], 'Bioessays.': [463], '1999;': [464, 508, 612, 647, 722, 845, 2729, 2854, 3573, 4182, 4400], '21:': [465], '718-720Crossref': [466], 'PubMed': [467, 511, 576, 615, 650, 670, 725, 768, 784, 848, 894, 963, 983, 1005, 1037, 1059, 1089, 1124, 1154, 1230, 1292, 2177, 2237, 2317, 2354, 2385, 2577, 2597, 2609, 2625, 2647, 2732, 2857, 2918, 3005, 3035, 3062, 3145, 3177, 3204, 3229, 3252, 3271, 3296, 3321, 3344, 3365, 3391, 3424, 3489, 3576, 3629, 3676, 3765, 3879, 4185, 4199, 4280, 4303, 4324, 4352, 4387, 4403, 4429, 4465], 'Scopus': [468, 577, 671, 769, 785, 895, 964, 1006, 1038, 1060, 1090, 1125, 1155, 1231, 1293, 1727, 2178, 2207, 2238, 2318, 2355, 2386, 2578, 2598, 2610, 2626, 2648, 2733, 2919, 3006, 3036, 3063, 3146, 3178, 3205, 3230, 3253, 3272, 3297, 3322, 3345, 3366, 3392, 3425, 3490, 3577, 3630, 3677, 3766, 3880, 4200, 4281, 4304, 4325, 4388, 4466], '(17)': [469], 'Google': [470, 512, 579, 616, 651, 673, 726, 745, 771, 787, 849, 897, 966, 984, 1008, 1018, 1040, 1062, 1092, 1127, 1157, 1233, 1295, 1729, 2124, 2180, 2209, 2240, 2320, 2357, 2388, 2580, 2600, 2612, 2628, 2650, 2735, 2858, 2921, 3008, 3038, 3065, 3148, 3180, 3207, 3232, 3255, 3274, 3299, 3324, 3347, 3368, 3394, 3427, 3492, 3579, 3632, 3679, 3768, 3882, 4186, 4202, 4283, 4306, 4327, 4353, 4390, 4404, 4430, 4468], 'Scholar).': [471, 513, 617, 674, 727, 788, 850, 898, 1093, 1158, 1234, 1296, 1730, 2125, 2241, 2358, 2389, 2581, 2651, 2736, 2859, 3428, 3493, 3580, 3633, 3680, 3883, 4469], 'Recently,': [472], 'however,': [473, 791], 'protein': [474, 1469, 1550, 1996, 4004], 'ability': [478], 'stimulate': [480], 'isolated': [487], 'fractionating': [489], 'conditioned': [490, 1167], 'medium': [491, 1168, 1246, 1372, 1393, 1409], 'cultures': [496], '(2.Kawamura': [497, 601, 636, 711, 834, 2843], 'K.': [498, 602, 637, 654, 712, 835, 989, 2844, 3379, 4332, 4334, 4375, 4409, 4411], 'Shibata': [499, 603, 638, 713, 836, 2845], 'T.': [500, 604, 639, 656, 714, 837, 2305, 2379, 2846, 3375, 4330, 4336, 4371, 4407, 4413], 'Saget': [501, 605, 640, 715, 838, 2847], 'O.': [502, 606, 641, 716, 839, 2848], 'Peel': [503, 607, 642, 717, 840, 2849], 'D.': [504, 608, 643, 718, 841, 2850, 3185], 'Bryant': [505, 609, 644, 719, 842, 2851], 'P.J.': [506, 610, 645, 720, 738, 843, 2604, 2852], 'Development.': [507, 611, 646, 721, 844, 2853], '126:': [509, 613, 648, 723, 846, 2855], '211-219Crossref': [510, 614, 649, 724, 847, 2856], 'These': [514, 801, 1542, 1607, 3725, 3844], 'molecules,': [516], 'termed': [517], '(IDGFs),1': [522], 'belong': [523], 'comprises': [531], 'least': [533, 4080], 'five': [534], 'members': [535], '(IDGF': [536], '1–5)': [537], 'having': [538], '∼50%': [539], 'identity': [543, 1494], 'one': [545, 1634], 'another.': [546], 'no': [548, 902, 917, 3104, 3776, 3892, 4257], 'specific': [549, 2711], 'assigned': [554, 2467], 'previously': [557], 'glycoprotein': [559, 1256], 'designated': [560], 'DS47': [561, 592], '(3.Kirkpatrick': [562, 1216], 'R.B.': [563, 1217, 4317], 'Matico': [564, 1218], 'R.E.': [565, 1219], 'McNulty': [566, 1220], 'D.E.': [567, 1221], 'Strickler': [568, 1222], 'J.E.': [569, 1223], 'Rosenberg': [570, 1224, 4318], 'M.': [571, 1021, 1108, 1225, 2297, 2346, 2566, 3262, 3279, 3303, 3480, 3756, 3870, 4264, 4286, 4319, 4340, 4417], 'Gene.': [572, 1226], '1995;': [573, 1051, 1146, 1227, 3249, 3293, 3336, 4300], '153:': [574, 1228], '147-154Crossref': [575, 1229], '(71)': [578, 1232], 'Scholar),': [580, 746, 1128, 2321, 2601, 2613, 2922, 3039, 3149, 3208, 3275, 3300, 3325, 3348, 3369, 3395, 4354, 4431], 'pattern': [587], 'expression': [589], 'suggest': [590], 'represents': [593], 'sixth': [595], 'IDGF': [599, 1204, 3733, 3910, 4234], 'IDGFs,': [618], 'act': [620, 808], 'nanomolar': [622], 'concentrations,': [623], 'among': [625], 'first': [627, 1162, 3515], 'be': [632, 933, 1329, 2784, 2830, 3529, 3550, 3945], 'identified': [633], 'invertebrates': [635], 'Scholar,': [652, 772, 967, 985, 1009, 1019, 1041, 1063, 3009, 3233, 3256, 4187, 4284, 4307, 4328, 4391, 4405], '4.Homma': [653], 'Matsushita': [655], 'Natori': [657], 'S.': [658, 2976, 3030, 3172, 3189, 3199, 3239, 3309, 3381, 3604, 4377, 4450], 'J.': [659, 974, 994, 1026, 1048, 1078, 1113, 1143, 2118, 2199, 2295, 2571, 2618, 3265, 3290, 3413, 3483, 3570, 3665, 3760, 3873, 4118, 4269, 4297, 4343, 4420], 'Biol.': [660, 780, 890, 958, 975, 995, 1027, 1049, 1079, 1114, 1144, 1288, 2312, 2573, 2642, 2914, 3267, 3292, 3414, 3485, 3572, 3666, 3875, 4195, 4270, 4299, 4344, 4421], 'Chem.': [661, 976, 996, 1028, 1050, 1080, 1115, 1145, 3415, 3667, 4271, 4345, 4422], '1996;': [662, 960, 997, 3268, 3486, 3876], '271:': [663, 998], '13770-13775Abstract': [664], 'Full': [665, 667, 980, 1000, 1002, 1032, 1034, 1054, 1056, 1084, 1086, 1119, 1121, 1149, 1151, 2172, 2174, 2232, 2234, 3000, 3002, 3057, 3059, 3140, 3142, 3224, 3226, 3339, 3341, 3419, 3421, 3624, 3626, 3671, 3673, 4275, 4277, 4349, 4426], 'Text': [666, 668, 981, 1001, 1003, 1033, 1035, 1055, 1057, 1085, 1087, 1120, 1122, 1150, 1152, 2173, 2175, 2233, 2235, 3001, 3003, 3058, 3060, 3141, 3143, 3225, 3227, 3340, 3342, 3420, 3422, 3625, 3627, 3672, 3674, 4276, 4278, 4350, 4427], 'PDF': [669, 982, 1004, 1036, 1058, 1088, 1123, 1153, 2176, 2236, 3004, 3061, 3144, 3228, 3343, 3423, 3628, 3675, 4279, 4351, 4428], '(61)': [672], 'expressed': [677, 732], 'only': [679, 1633, 3972], 'discs': [683], 'but': [684, 916, 1968, 2085, 3040, 3103, 3594], 'also': [685, 730, 1211, 2973, 3444, 3645, 3886, 4076], 'throughout': [686], 'all': [687, 2408, 2484, 2510, 3521, 3557, 3731], 'developmental': [688], 'stages': [689], 'variable': [691, 3848], 'patterns,': [692], 'early': [694, 750], 'embryo': [695], 'glands': [699], 'tissues,': [701], 'well': [703, 2437, 3096, 3737, 3966, 4433], 'nurse': [707], 'oocytes': [710], 'strongly': [731], 'fat': [735, 755], 'body': [736, 756], '(5.Bryant': [737], 'Novartis': [739], 'Found': [740], 'Symp.': [741], '2001;': [742, 1081, 3201, 3416, 3668], '237:': [743], '182-194PubMed': [744], 'accordance': [748], 'reports': [751], 'showing': [752], 'produces': [757, 1184], '(6.Davis': [760], 'K.T.': [761, 776], 'Shearn': [762], 'A.': [763, 774, 2155, 2203, 2222, 2350, 2588, 2983, 3031, 3123, 3173, 3200, 3243, 3565, 3607, 3752], 'Science.': [764, 2605], '1977;': [765], '196:': [766], '438-440Crossref': [767], '(69)': [770], '7.Shearn': [773], 'Davis': [775], 'Hersperger': [777], 'E.': [778, 2723, 3018, 3160, 4446], 'Dev.': [779], '1978;': [781], '65:': [782], '536-540Crossref': [783], '(11)': [786], 'At': [789], 'present,': [790], 'little': [792], 'known': [794, 903, 2669], 'about': [795], 'how': [796], 'proliferation.': [800], 'mammalian': [810, 3398, 3772], 'through': [818], 'receptor,': [822, 1342], 'suggesting': [823], 'role': [825], 'cofactors': [827], 'or': [831, 1272, 1666, 1977, 2094, 2614, 2693, 3115, 3601, 3803], 'insulin-like': [832], 'molecules': [833], 'present': [852, 934, 1637, 2476, 2974, 3445, 3795], '15–25%': [853], 'includes': [864, 2403], 'chitinases,': [866, 3094, 3469], 'enzymes': [867], 'catalyze': [869], 'hydrolysis': [871, 4169], 'β-(1,': [873], '4)-N-acetyl-d-glucosamine': [874], 'linkages': [875, 2880], 'polymers': [878], 'arthropod': [881], 'cuticle': [882], '(8.Henrissat': [883, 1281, 2907], 'Davies': [885, 1283, 2909], 'G.': [886, 1284, 2377, 2910, 4452], 'Curr.': [887, 1285, 2911, 4192], 'Opin.': [888, 1286, 2912, 4193], 'Struct.': [889, 1287, 2913, 4194], '1997;': [891, 1289, 1724, 2229, 2382, 2622, 2915], '7:': [892, 1290, 2916], '637-644Crossref': [893, 1291, 2917], '(1379)': [896, 1294, 2920], 'activity.': [905, 1315, 3843], 'In': [906, 1380, 1629, 3781, 3805, 4230], 'this': [907, 1408, 2810, 3070, 3951, 4072], 'respect,': [908], 'detectable': [918], 'vertebrates,': [925], 'indicating': [926], 'typical': [929], 'chitinase-like': [930, 3076, 3101, 3650, 3773, 3889, 4254], 'fold': [931, 2901], 'wide': [939], 'range': [940, 1953], 'biological': [942], 'other': [944, 4218, 4233, 4253], 'than': [945], 'degradation': [947], '(9.Buhi': [948], 'W.C.': [949], 'Alvarez': [950], 'I.M.': [951], 'Choi': [952], 'I.': [953, 1071, 2157, 2163, 2530, 2985, 2991, 3125, 3131, 3609, 3615], 'Cleaver': [954], 'B.D.': [955], 'Simmen': [956], 'F.A.': [957], 'Reprod.': [959], '55:': [961], '1305-1314Crossref': [962], '(62)': [965], '10.Hakala': [968], 'B.E.': [969], 'White': [970], 'C.': [971, 2224, 3311, 3331], 'Recklies': [972], 'A.D.': [973], '1993;': [977, 2121, 4346, 4423], '268:': [978, 4347, 4424], '25803-25810Abstract': [979], '11.Hu': [986], 'Trinh': [988], 'Figueira': [990], 'W.F.': [991], 'Price': [992], 'P.A.': [993], '19415-19420Abstract': [999], '(168)': [1007], '12.Morrison': [1010], 'B.W.': [1011, 3020, 3052, 3162, 3219, 3247, 3264, 3287, 3482, 3872, 4294], 'Leder': [1012], 'P.': [1013, 2289, 2721, 3334, 3353, 4458], 'Oncogene.': [1014], '1994;': [1015, 2169, 2204, 2644, 2997, 3054, 3137, 3221, 3362, 3621, 4196, 4462], '9:': [1016, 3389, 4385], '3417-3426PubMed': [1017], '13.Owhashi': [1020], 'Arita': [1022, 1109, 4265], 'H.': [1023, 1110, 2568, 4266, 4338, 4342, 4415, 4419], 'Hayai': [1024, 1111, 4267], 'N.': [1025, 1112, 4268], '2000;': [1029, 1116, 3032, 3174, 3388, 4272, 4384], '275:': [1030, 1117, 4273], '1279-1286Abstract': [1031, 1118, 4274], '(117)': [1039, 1126, 4282], '14.Shackelton': [1042], 'L.M.': [1043, 1138, 2303], 'Mann': [1044, 1139], 'D.M.': [1045, 1140], 'Millis': [1046, 1141], 'A.J.': [1047, 1142], '270:': [1052, 1147], '13076-13083Abstract': [1053, 1148], '(190)': [1061, 1156], '15.Chang': [1064], 'N.-C.A.': [1065, 3404, 3656], 'Hung': [1066, 3405, 3657], 'S.-I.': [1067, 3406, 3658], 'Hwa': [1068], 'K.-Y.': [1069], 'Kato': [1070], 'Chen': [1072, 4176, 4394], 'J.-E.': [1073], 'Liu': [1074], 'C.-H.': [1075], 'Chang': [1076, 3403, 3407, 3655, 3659], 'A.C.': [1077, 3046, 3213, 3237, 3260, 3285, 3408, 3478, 3660, 3868, 4292], '276:': [1082, 1725, 3417, 3669], '17497-17506Abstract': [1083], '(210)': [1091], 'For': [1094, 1642, 2271, 2499], 'example,': [1095], 'mouse': [1096], 'ECF-L': [1097], 'chemotactic': [1103], 'eosinophils': [1106], '(13.Owhashi': [1107, 4263], 'porcine': [1130], 'GP38K': [1131], 'associated': [1133], 'tissue': [1135], 'remodeling': [1136], '(14.Shackelton': [1137], 'was': [1161, 1257, 1263, 1418, 1440, 1470, 1489, 1495, 2136, 2257, 2276, 2367, 2716, 2741, 2796], 'obtained': [1163, 1610], 'characterized': [1165], 'cultures,': [1173], 'we': [1174], 'found': [1176, 3646], 'Schneider': [1179, 1355], 'SL3': [1180, 1240, 1356], 'embryo-derived': [1181, 1213], 'line': [1183, 1215], 'under': [1186, 1481, 2549], 'conditions.': [1189, 1483], 'This': [1190, 3884, 4248], 'agreement': [1193], 'identification': [1196], 'DS47,': [1198, 2700], 'likely': [1200], 'family,': [1205], 'culture': [1207, 1416], 'supernatants': [1208], 'S2,': [1210], 'purified': [1237, 1255, 1472, 3963], 'grown': [1242, 1403, 1545], 'supplemented': [1244, 1373], 'complete': [1245], 'then': [1248, 1411, 1441], 'allowed': [1249, 2247], 'condition': [1251], 'serum-free': [1252], 'medium.': [1253, 4040], 'crystallized,': [1258], 'three-dimensional': [1261], 'determined': [1264, 2137], 'high': [1266, 2819], 'resolution,': [1267], 'revealing': [1268], 'characteristic': [1270, 2900], 'triose-phosphate': [1273, 3561], 'isomerase': [1274, 3562], 'hydrolases': [1280, 2906, 3559, 3800], 'enables': [1299], 'us': [1300], 'explain': [1302], 'some': [1303, 3856, 4081], 'unique': [1306], 'characteristics': [1307], 'IDGF-2,': [1309, 3447, 3964], 'including': [1310, 2322], 'lack': [1312, 4056], 'chitinase': [1314, 2152, 2672, 2680, 3106, 3120, 3150, 3372, 3524, 3599, 3777, 4161], 'Certain': [1316], 'features': [1317], 'homologous': [1321], 'chitin-binding': [1324], 'significance': [1331], 'ligands,': [1337], 'account': [1345], 'potent': [1348], 'effects': [1350], 'Embryo-derived': [1354], 'were': [1359, 1387, 1402, 1505, 1544, 1609, 1647, 1670, 1709, 1984, 2101, 2194, 2217, 2398, 2466, 2559, 2583, 2654, 2689], 'routinely': [1360], 'cultured': [1361], 'suspension': [1363], '(shaker': [1364], 'flasks)': [1365], '28': [1367], '°C,': [1368], 'Sf-900': [1370], 'II': [1371], '3%': [1375], 'fetal': [1376, 1398], 'bovine': [1377, 1399], 'serum': [1378], '(Invitrogen).': [1379], 'last': [1382, 2360, 2887], 'passage': [1383], 'before': [1384], 'harvesting,': [1385], 'diluted': [1388], '1:5': [1389], 'SFM': [1392], '(Invitrogen),': [1394], 'without': [1395], 'addition': [1396], 'serum.': [1400], 'Cells': [1401], '3': [1405, 2715], 'days': [1406], 'harvested.': [1412], 'After': [1413], 'centrifugation,': [1414], 'supernatant': [1417, 1439], 'dialyzed': [1419], 'against': [1420], '20': [1421, 1453, 2516], 'mm': [1422, 1461], 'Tris-HCl,': [1423], 'pH': [1424, 1455, 1572, 1622], '7.9,': [1425], 'concentrated': [1427], '4-fold': [1428], 'using': [1429, 1463, 1624, 1714, 2263, 2278, 2337, 2370, 2718], 'spiral': [1431], 'cartridge': [1432], 'ultrafiltration': [1433], 'system': [1434], '(Amicon,': [1435], 'Beverly,': [1436], 'MA).': [1437], 'applied': [1442], 'Q-Sepharose': [1445], 'anion': [1446], 'exchange': [1447], 'column': [1448, 1477], '(Amersham': [1449, 1478], 'Biosciences)': [1450, 1479], 'equilibrated': [1451], 'mmTris-HCl,': [1454], '7.9.': [1456], 'eluted': [1458], '50': [1460], 'NaCl': [1462], 'linear': [1465], 'salt': [1466], 'gradient.': [1467], 'further': [1471, 2802], 'Mono': [1475], 'Q': [1476], 'run': [1480], 'final': [1485, 2401], 'yield': [1486], '∼2': [1490], 'mg/liter': [1491], 'culture.': [1492], 'Protein': [1493, 2546, 3386, 4382], 'verified': [1496], 'N-terminal': [1498, 3817, 4008], 'sequencing.': [1499], 'Two': [1500], 'forms': [1502, 2375, 2525, 2538, 2754, 2962, 3114, 3918], 'obtained,': [1506], 'trigonal': [1507, 1513, 1683, 2140, 2269, 2427, 2470, 2496, 2535, 2748, 2800], 'orthorhombic': [1509, 1578, 1696, 2254, 2429, 2472, 2501, 2537, 2750], '(Table': [1510, 2751], 'I).': [1511, 2752], 'form': [1514, 1579, 2142, 2256], 'belongs': [1515, 1580], 'space': [1517, 1582], 'group': [1518, 1583], 'P3221': [1519, 1813, 1835, 1858, 1880, 1922, 1944, 2043], 'unit': [1521, 1586], 'dimensions': [1523, 1588], '=': [1525, 1527, 1531, 1535, 1537, 1540, 1590, 1594, 1597, 1601, 1603, 1605, 1759, 1763, 1767, 1769, 1771, 1774, 1776, 1779, 1783, 1786, 1788, 2478, 2507], 'b': [1526, 1593, 1778], '106.4': [1528, 1760], 'Å,': [1529, 1533, 1592, 1599, 1761, 1765, 1781], 'c': [1530, 1762, 1782], '90.0': [1532, 1764], '90.0o,': [1538], 'γ': [1539, 1604, 1770, 1773, 1789], '120o.': [1541], 'crystals': [1543, 1608, 1646], 'mixing': [1547], 'aliquots': [1548], 'solution,': [1551], '10': [1553], 'mg/ml,': [1554], 'equal': [1557], 'volume': [1558], 'reservoir': [1561, 1652], 'solution': [1562, 1653], 'consisting': [1563, 2930], '12%': [1565], 'polyethylene': [1566, 1616], 'glycol': [1567, 1617, 1657], '4000,': [1568, 1618], '0.1': [1569, 1619], 'msodium': [1570], 'acetate,': [1571], '5.0,': [1573], '4': [1575], '°C.': [1576], 'P212121': [1584], '49.5': [1591], '72.2': [1595, 1780], 'Å,c': [1596], '105.8': [1598], '90.0o.': [1606], '25': [1612], '°C': [1613], '25%': [1615], 'm': [1620], 'Tris,': [1621], '7.0,': [1623], '15': [1627, 2190], 'mg/ml.': [1628], 'both': [1630, 2272, 2373, 2394, 2412, 2523], 'forms,': [1632, 2274, 2430, 2473, 2747], 'molecule': [1635], 'asymmetric': [1640, 1753], 'unit.': [1641], 'cryogenic': [1643], 'data': [1644, 1740, 2485, 2511], 'collection,': [1645], 'harvested': [1648], 'modified': [1651], 'containing': [1654], '20%': [1655], 'ethylene': [1656], 'cryoprotectant': [1659], 'flash-cooled': [1661], 'plunging': [1663], 'into': [1664], 'propane': [1665], 'liquid': [1667], 'nitrogen.': [1668], 'Data': [1669, 1708, 1731, 2547, 2675], 'collected': [1671], 'beamline': [1673, 1687], 'X12B': [1674], 'Brookhaven': [1677], 'National': [1678], 'Synchrotron': [1679, 1693], 'Laboratory': [1680], '(for': [1681, 1694, 1975, 1979, 2092, 2096], 'form)': [1684, 1697], 'X11': [1688], 'Deutsche': [1691], 'Elektronen': [1692], 'ADSC': [1699], 'quantum4': [1700], 'Mar': [1702], 'Research': [1703], 'CCD': [1704], 'plate': [1705], 'detectors,': [1706], 'respectively.': [1707, 2431, 2474], 'integrated,': [1710], 'scaled,': [1711], 'merged': [1713], 'HKL': [1716], 'package': [1717], '(16.Otwinowski': [1718], 'Z.': [1719, 2159, 2987, 3127, 3307, 3611], 'Minor': [1720], 'W.': [1721], 'Methods': [1722, 2380], 'Enzymol.': [1723, 2381], '307-326Crossref': [1726], '(38253)': [1728], 'statistics': [1732, 1745, 2521], 'given': [1734, 2527], 'Table': [1736, 2529], 'I.Table': [1737], 'ISummary': [1738], 'collection': [1741, 1748], 'model': [1743, 2335, 2402], 'refinement': [1744, 2275, 2366], 'IDGF-2Data': [1747], 'Space': [1749], 'groupP3221P212121': [1750], 'Molecules': [1751], 'per': [1752], 'unit11': [1754], 'Unit': [1755], 'dimensionsa': [1757], '=b': [1758], '90.0°,': [1772], '120°a': [1775], '49.5Å,': [1777], '105.8Å,': [1784], '90.0°': [1790], 'Resolution': [1791, 1952], '(Å)1.31.7': [1792], 'Total': [1793], 'observations758,311303,904': [1794], 'Unique': [1795], 'reflections129,90440,966': [1796], 'Completeness': [1797], '(%)90.3': [1798], '(53.5)1-aValues': [1799], 'parentheses': [1801, 1823, 1846, 1868, 1910, 1932, 2031], 'correspond': [1802, 1824, 1847, 1869, 1911, 1933, 2032], 'highest': [1805, 1827, 1850, 1872, 1914, 1936, 2035], 'resolution': [1806, 1828, 1851, 1873, 1915, 1937, 2036, 2793], 'shell': [1807, 1829, 1852, 1874, 1916, 1938, 2037], '(1.33': [1808, 1830, 1853, 1875, 1917, 1939, 2038], '1.30': [1810, 1832, 1855, 1877, 1919, 1941, 2040], 'Å': [1811, 1818, 1833, 1840, 1856, 1863, 1878, 1885, 1920, 1927, 1942, 1949, 2041, 2048, 2193, 2493, 2766], '1.74': [1815, 1837, 1860, 1882, 1924, 1946, 2045], '1.70': [1817, 1839, 1862, 1884, 1926, 1948, 2047], 'P212121).98.2': [1820], '(80.8)1-aValues': [1821], 'P212121).': [1842, 1887], 'I/ς<I>23.82': [1843], '(2.88)1-aValues': [1844], 'P212121).23.27': [1865], '(6.05)1-aValues': [1866], 'Rsym1-bRsym=∑‖Ij': [1888], '−': [1889, 1956, 2052, 2072], '<I>/∑Ij': [1890, 2053], 'where': [1891, 1958, 2054, 2074], 'Ijis': [1892, 2055], 'intensity': [1894, 1904, 2057, 2067], 'individual': [1897, 2060, 2363], 'reflection': [1898, 2061], '<I>': [1900, 2063], 'average': [1903, 2066], 'reflection.2.3': [1907], '(25.7)1-aValues': [1908], 'P212121).4.3': [1929], '(27.4)1-aValues': [1930], 'P212121).Refinement': [1951], '(Å)100–1.320–1.7': [1954], 'Rcryst1-cRcryst=∑‖‖Fo‖': [1955], '‖Fc‖/∑‖Fc‖‖,': [1957, 2073], 'Fcis': [1959, 2075], 'calculated': [1961, 1969, 2020, 2077, 2086, 2107], 'factor./Rfree1-dRfree': [1963], 'Rcryst,': [1967, 2084], 'randomly': [1972, 2089], 'chosen': [1973, 2090], '1.8%': [1974, 2091], 'P3221)': [1976, 2093], '10.1%': [1978, 2095], 'P212121)': [1980, 2097], 'reflections': [1982, 2099], 'omitted': [1985, 2102], 'refinement.(%)17.6/20.219.5/25.9': [1988], 'Reflections': [1989], 'Working': [1990], 'set127,32736,692': [1991], 'Rfreeset2,2984,114': [1992], 'Number': [1993, 1998, 2002], 'non-hydrogen': [1995], 'atoms3,1663,166': [1997], 'solvent': [2000, 2324, 2464], 'atoms701439': [2001], 'heteroatoms5050': [2004], 'Root': [2005], 'mean': [2006], 'square': [2007], 'deviations': [2008], 'ideality': [2010], 'Bond': [2011, 2014], 'lengths': [2012], '(Å)0.0060.006': [2013], 'angles': [2015], '(°)1.6001.540': [2016], 'Ramachandran': [2017], 'plot': [2018], 'statistics1-eAs': [2019], 'PROCHECK': [2022, 2109], '(56).': [2023], 'Most': [2024], 'favored': [2025], '(%)91.289.1': [2026], 'Allowed': [2027], '(%)8.810.91-a': [2028], 'Values': [2029], 'P212121).1-b': [2050], 'Rsym=∑‖Ij': [2051], 'reflection.1-c': [2070], 'Rcryst=∑‖‖Fo‖': [2071], 'factor.1-d': [2079], 'Rfree': [2080, 2397, 2506], 'refinement.1-e': [2105], 'As': [2106, 2890], '(56.Laskowski': [2110], 'R.A.': [2111], 'MacArthur': [2112], 'M.W.': [2113], 'Moss': [2114], 'D.S.': [2115], 'Thornton': [2116], 'J.M.': [2117], 'Appl.': [2119], 'Crystallog.': [2120], '26:': [2122], '283-291Crossref': [2123], 'Open': [2126], 'table': [2127], 'tab': [2131], 'molecular': [2144, 2261, 3981], 'truncated': [2147], 'coordinates': [2148, 2266, 2532], '(17.Perrakis': [2154, 2982, 3122, 3606], 'Tews': [2156, 2984, 3124, 3608], 'Dauter': [2158, 2986, 3126, 3306, 3610], 'Oppenheim': [2160, 2988, 3128, 3612], 'A.B.': [2161, 2989, 3129, 3613], 'Chet': [2162, 2990, 3130, 3614], 'Wilson': [2164, 2225, 2992, 3132, 3314, 3616], 'K.S.': [2165, 2226, 2993, 3133, 3315, 3617], 'Vorgias': [2166, 2994, 3134, 3618], 'C.E.': [2167, 2995, 3135, 3619], 'Structure.': [2168, 2996, 3053, 3136, 3220, 3335, 3620], '2:': [2170, 2230, 2998, 3055, 3138, 3222, 3622], '1169-1180Abstract': [2171, 2999, 3139, 3623], '(374)': [2179, 3007, 3147, 3631], 'Scholar)': [2181, 2210, 2629, 3066, 3769, 4203], 'search': [2184], 'model.': [2185], 'Normalized': [2186], '4.5': [2192], 'used': [2195], 'AMoRe': [2197], '(18.Navaza': [2198], 'Acta': [2200, 2308, 2347, 2638], 'Crystallogr.': [2201, 2309, 2313, 2348, 2639, 2643], 'Sect.': [2202, 2310, 2349, 2640], '50:': [2205, 2645], '157-163Crossref': [2206], '(5026)': [2208], 'rotation': [2211], 'translation': [2213], 'functions.': [2214], 'Model': [2215], 'phases': [2216], 'improved': [2218], 'wARP': [2220], '(19.Perrakis': [2221], 'Ouzounis': [2223], 'Folding': [2227], 'Des.': [2228], '291-294Abstract': [2231], '(25)': [2239], 'resulting': [2243, 4070], 'electron': [2244, 2422, 2814, 3920, 4058], 'density': [2245, 2423, 2815, 3921, 4059], 'map': [2246], 'unambiguous': [2248], 'rebuilding': [2249, 2336], 'molecule.': [2252], 'readily': [2258], 'solved': [2259, 2742], 'refined': [2265], 'form.': [2270, 2498, 2812], 'performed': [2277], 'CNS1.0': [2279], '(20.Brunger': [2280], 'A.T.': [2281], 'Adams': [2282], 'P.D.': [2283], 'Clore': [2284], 'G.M.': [2285], 'DeLano': [2286], 'W.L.': [2287], 'Gros': [2288], 'Grosse-Kunstleve': [2290], 'R.W.': [2291], 'Jiang': [2292], 'J.-S.': [2293], 'Kuszewski': [2294], 'Nilges': [2296], 'Pannu': [2298], 'N.S.': [2299], 'Read': [2300], 'R.J.': [2301], 'Rice': [2302], 'Simonson': [2304], 'Warren': [2306], 'G.L.': [2307], 'D': [2311, 2641], '1998;': [2314, 3762, 4321], '54:': [2315, 4322], '905-921Crossref': [2316], '(16919)': [2319], 'bulk': [2323], 'correction': [2325], 'overall': [2327], 'anisotropic': [2328, 2364], 'scaling,': [2329], 'interspersed': [2330], 'iterative': [2332], 'rounds': [2333], 'O': [2338], '(21.Jones': [2339], 'T.A.': [2340], 'Zou': [2341], 'J.Y.': [2342], 'Cowan': [2343], 'S.W.': [2344], 'Kjeldgaard': [2345], '1991;': [2351, 2594, 2606], '47:': [2352], '110-119Crossref': [2353], '(12999)': [2356], 'round': [2361], 'B-factor': [2365], 'carried': [2368, 2655], 'out': [2369, 2656], 'SHELX': [2371], '(22.Sheldrick': [2376], 'Shneider': [2378], '277:': [2383], '319-343Crossref': [2384], '(1867)': [2387], 'Only': [2390], 'procedures': [2391], 'minimized': [2393], 'Rcryst': [2395, 2477], 'used.': [2399], '91.2': [2404], '89.1%': [2406], 'fitted': [2410], 'averaged': [2413], 'unaveraged': [2415], 'ςA-weighted': [2416], '2Fo': [2417], '−Fc': [2418, 2421], 'Fo': [2420], 'maps,': [2424], 'All': [2432], 'regions': [2433], 'ordered,': [2438], 'exception': [2441], 'missing': [2444], 'loop': [2445, 2778, 3692, 3718, 3943, 3952, 4066, 4110], 'between': [2446, 2489, 2515, 2954, 3683, 3693, 3719, 3810, 3922, 4051], 'Val-141': [2447, 3923], 'Ile-161.': [2449], 'Both': [2450, 2753], 'models': [2451], 'contain': [2452], '2': [2454], '141': [2456], '161': [2458], '420;': [2460], '701': [2461], '439': [2463], 'atoms': [2465], '17.6%': [2479], 'Rfree=': [2481], '20.2%': [2482], '(F': [2486, 2512], '>': [2487, 2513], '0)': [2488, 2514], '100': [2490], '1.3': [2492], 'form,': [2502], 'Rcryst=': [2503], '19.5%': [2504], '25.9%': [2508], '1.7': [2518], 'Å.': [2519], 'Refinement': [2520], 'Atomic': [2531], 'deposited': [2543], 'Bank': [2548, 2676], 'accession': [2550, 2677], 'codes': [2551], '1JND': [2552], '1JNE,': [2554], 'respectively': [2555], '(http://www.rcsb.org).': [2556], 'Structure': [2557], 'superpositions': [2558], 'done': [2560], 'SHP': [2562], '(23.Stuart': [2563], 'D.I.': [2564, 2725], 'Levine': [2565], 'Muirhead': [2567], 'Stammers': [2569], 'D.K.': [2570], 'Mol.': [2572, 2619, 3266, 3291, 3484, 3571, 3874, 4298], '1979;': [2574], '134:': [2575], '109-142Crossref': [2576], '(372)': [2579], 'Figs.': [2582], 'produced': [2584], 'GRASP': [2586], '(24.Nicholls': [2587], 'Sharp': [2589], 'K.A.': [2590], 'Honig': [2591], 'Proteins.': [2593], '11:': [2595], '281-296Crossref': [2596], '(5311)': [2599], 'MOLSCRIPT': [2602], '(25.Kraulis': [2603], '254:': [2607, 3294, 4301], '581-582Crossref': [2608], '(46)': [2611], 'BOBSCRIPT': [2615], '(26.Esnouf': [2616], 'R.M.': [2617], 'Graph.': [2620], 'Model.': [2621], '15:': [2623, 2730], '132-134Crossref': [2624], '(1794)': [2627], 'rendered': [2631], 'RASTER3D': [2633], '(27.Merritt': [2634], 'E.A.': [2635], 'Murphy': [2636], 'M.E.P.': [2637], '869-873Crossref': [2646], '(2854)': [2649], 'Sequence': [2652], 'alignments': [2653], 'ClustalW': [2658], 'ExPASy': [2660], '(www.expasy.ch),': [2661], 'subsequently': [2663], 'edited': [2664], 'manually': [2665], 'based': [2666, 2808], '(Protein': [2674], 'code': [2678], '1CNV),': [2679], 'B': [2681, 2981, 3151, 3277, 3602], '(1E15),': [2682], 'hevamine': [2683, 3042, 3209], '(2HVM),': [2684], 'Ym1': [2686, 3400, 3652, 4357], '(1E9L).': [2687], 'Sequences': [2688], 'retrieved': [2690], 'GenBankTM': [2692], 'SwissProt': [2694], '(IDGFs': [2695], '1–4,': [2696], 'AAC99417–20;': [2697], 'IDGF-5,': [2698], 'AAF57703.1;': [2699], 'AAC48306;': [2701], 'BRP39,': [2702], 'S61550;': [2703], 'HCGP-39,': [2704], 'AAA16074;': [2705], 'GP38K,': [2706], 'AAA86482;': [2707], 'YKL-39,': [2708], 'AAC50597;': [2709], 'oviduct': [2710], 'glycoprotein,': [2712], 'Q28990).': [2713], 'Fig.': [2714, 2824, 3899, 4246], 'drawn': [2717], 'ESPript': [2719], '(28.Gouet': [2720], 'Courcelle': [2722], 'Stuart': [2724], 'Metoz': [2726], 'F.': [2727], 'Bioinformatics.': [2728], '305-308Crossref': [2731], '(2499)': [2734], 'two': [2744, 2865, 2869, 3500, 3636, 3916, 3989], 'show': [2755], 'essentially': [2756], 'same': [2758], 'structure,': [2759, 3642], 'root-mean-square': [2762], 'difference': [2763], '0.5': [2765], '398': [2768], 'Cα': [2769], 'atoms.': [2770], 'greatest': [2772], 'deviation': [2773], 'occurs': [2774], 'external': [2777, 4039], 'comprising': [2779], '320–340': [2781], 'can': [2783, 2829], 'attributed': [2785], 'differences': [2787], 'packing.': [2790], 'Because': [2791], 'better': [2792], '(1.3': [2794], 'Å)': [2795], 'achieved': [2797], 'crystal,': [2801], 'description': [2803], 'maps': [2816], 'quality,': [2820], '1.': [2825], 'carbohydrate': [2827], 'chain': [2828, 4473], 'traced': [2831], 'attached': [2832], 'Asn-200': [2834], 'conserved': [2837, 3437, 3519, 3597, 3729], 'N-linked': [2838], 'glycosylation': [2839], 'visible': [2861], 'sugar': [2862], 'include': [2864], 'N-acetylglucosamines': [2866], '(NAGs)': [2867], 'mannoses.': [2870], 'NAGs': [2872], 'linked': [2874], 'neighbor': [2877], 'β(1–4)': [2879], 'α(1–3)': [2883], 'linkage': [2884], 'binds': [2885], 'Man': [2888], 'residue.': [2889], 'predicted': [2891, 4023], 'similarity,': [2896], 'adopts': [2898], 'barrel': [2925, 2944, 2952, 3453, 3807], '(residues': [2926, 2960, 3903], '2–279': [2927], '371–420),': [2929], 'eight-stranded': [2933], 'parallel': [2934], 'β-barrel': [2935], '(β1-β8)': [2936], 'surrounded': [2937], 'eight': [2939], 'α-helices': [2940, 3820], 'antiparallel': [2941], '(α1-α8)': [2945], '(Fig.': [2946, 3067, 3088, 3455, 3512, 3779, 4153, 4242, 4261, 4358], '2).': [2947, 3068], 'An': [2948], 'motif': [2953], 'strand': [2955, 3688, 3697, 3720, 3812, 3829], 'β7': [2956], 'helix': [2958, 3694, 3723], 'α7': [2959], '280–370)': [2961], 'additional': [2964], 'β-fold': [2970], '29.van': [3010], 'Aalten': [3011, 3153, 3182], 'D.M.F.': [3012, 3154, 3183], 'Synstad': [3013, 3155, 3186], 'Brurberg': [3015, 3157], 'M.B.': [3016, 3158], 'Hough': [3017, 3159], 'Riise': [3019, 3161], 'Eijsink': [3021, 3163, 3192], 'V.G.H.': [3022, 3164, 3193], 'Wierenga': [3023, 3165], 'R.K.': [3024, 3166], 'Proc.': [3025, 3167, 3194], 'Natl.': [3026, 3168, 3195], 'Acad.': [3027, 3169, 3196], 'Sci.': [3028, 3170, 3197, 3387, 4383], 'U.': [3029, 3171, 3198], '97:': [3033, 3175], '5842-5847Crossref': [3034, 3176], '(239)': [3037, 3179], '(30.Terwisscha': [3043, 3210], 'van': [3044, 3211, 3235, 3258, 3283, 3476, 3866, 4290], 'Scheltinga': [3045, 3212, 3236, 3259, 3284, 3477, 3867, 4291], 'Kalk': [3047, 3214, 3240], 'K.H.': [3048, 3215, 3241], 'Beintema': [3049, 3216], 'J.J.': [3050, 3217], 'Dijkstra': [3051, 3218, 3246, 3263, 3286, 3481, 3871, 4293], '1181-1189Abstract': [3056, 3223], '(217)': [3064, 3231], 'Interestingly,': [3069, 4470], 'feature': [3071], 'common': [3073], 'most': [3075, 4061], 'date,': [3080], 'although': [3081, 3846], 'length': [3083, 3850], 'varies': [3087], '3).': [3089, 3513, 3780], 'folds': [3102], 'apparent': [3105, 3893, 4258], 'activity,': [3107, 3895], 'reported,': [3110], 'free': [3113], 'complexes': [3117], 'ligands:': [3119], '(29.van': [3152], 'Scholar,31.van': [3181], 'Komander': [3184], 'Gaseidnes': [3188], 'Peter': [3190], 'M.G.': [3191], '98:': [3202], '8979-8984Crossref': [3203], '(388)': [3206], '32.Terwisscha': [3234], 'Armand': [3238], 'Isogai': [3242], 'Henrissat': [3244], 'Biochemistry.': [3248, 3361], '34:': [3250], '15619-15623Crossref': [3251], '(304)': [3254], '33.Terwisscha': [3257], 'Hennig': [3261, 3479, 3869], '262:': [3269, 3487, 3877], '243-257Crossref': [3270, 3488, 3878], '(164)': [3273, 3491, 3881], 'concanavalin': [3276], '(34.Hennig': [3278], 'Jansonius': [3280, 4287], 'J.N.': [3281, 4288], 'Terwisscha': [3282, 4289], 'Schlesier': [3288, 3304, 4295], '237-246Crossref': [3295, 4302], '(75)': [3298, 4305], 'narbonin': [3301], '(35.Hennig': [3302], 'Pfeffer': [3308], 'Betzel': [3310], 'Hohne': [3312], 'W.E.': [3313, 3750], 'FEBS': [3316], 'Lett.': [3317], '1992;': [3318], '306:': [3319], '80-84Crossref': [3320], '(51)': [3323], 'endoglycosidase': [3326, 3349, 4436], 'H': [3327], '(36.Rao': [3328], 'V.': [3329, 3355], 'Guan': [3330], 'Van': [3332], 'Roey': [3333, 3352], '3:': [3337], '449-457Abstract': [3338], '(54)': [3346], 'F': [3350], '(37.Van': [3351], 'Rao': [3354], 'Plummer': [3356], 'Jr.,': [3357], 'T.H.': [3358], 'Tarentino': [3359], 'A.L.': [3360], '33:': [3363], '13989-13996Crossref': [3364], '(55)': [3367], 'Coccidioides': [3370], 'immitis': [3371], '1': [3373], '(38.Hollis': [3374, 4370], 'Monzingo': [3376, 4372], 'A.F.': [3377, 4373], 'Bortone': [3378, 4374], 'Ernst': [3380, 4376], 'Cox': [3382, 4378], 'R.': [3383, 3569, 4379], 'Robertus': [3384, 4380], 'J.D.': [3385, 4189, 4381], '544-551Crossref': [3390, 4386], '(108)': [3393, 4389], 'lectin': [3399, 3651], '(39.Sun': [3401, 3653], 'Y.-J.': [3402, 3654], 'Chou': [3409, 3661], 'C.-C.': [3410, 3662], 'Hsiao': [3411, 3663], 'C.-D.': [3412, 3664], '17507-17514Abstract': [3418, 3670], '(86)': [3426, 3678], 'Despite': [3429], 'low': [3430], '(22–25%': [3433], 'similarity),': [3434], 'few': [3436], 'seem': [3448, 3548], 'essential': [3449, 4113], 'maintain': [3451], 'folding': [3454, 3533], '3;': [3456], 'white': [3459], 'over': [3460], 'red': [3461], 'background)': [3462], 'and,': [3463], 'case': [3466], 'active': [3468, 4123], 'substrate-binding': [3473], 'sites': [3474], '(33.Terwisscha': [3475, 3865], 'three': [3496], 'cis': [3497, 3543, 3583], 'peptide': [3498, 4031], 'bonds,': [3499], 'them': [3502], 'involving': [3504], 'proline': [3506], 'residue:': [3507], 'Gly-39–Tyr-40,': [3508], 'Pro-295–Val-296,': [3509], 'Phe-394–Asp-395': [3511], 'third': [3517], 'appear': [3527], 'necessary': [3530], 'correct': [3532], 'barrel.': [3536], 'aromatic': [3538, 4145], 'involved': [3540, 3786, 3835], 'these': [3542, 3929], 'bonds': [3544], '(Tyr-40': [3545], 'Phe-394)': [3547], 'substrate': [3555, 3839, 3863, 4152, 4215], 'barrel-folds': [3563], '(40.Jabs': [3564], 'Weiss': [3566], 'M.S.': [3567], 'Hilgenfeld': [3568], '286:': [3574], '291-304Crossref': [3575], '(273)': [3578], 'Pro-295–Val-296': [3582], 'bond': [3584, 3789, 4173], 'located': [3586], 'inserted': [3589, 3711], 'There': [3634], 'disulfide': [3637, 3788], 'bridges': [3638], 'murine': [3649], 'first,': [3682], 'Cys-6': [3684], 'Cys-33,': [3686], 'links': [3687], 'β1': [3689], 'α1': [3695], 'β2.': [3698], 'second,': [3700], 'formed': [3701, 4132], 'Cys-322': [3703], 'Cys-405,': [3705], 'connects': [3706], 'α-helix': [3708], 'β8': [3721], 'α8.': [3724], 'Cys': [3726, 3784], 'six': [3732], 'members,': [3735, 4236], 'human': [3741], 'chitotriosidase': [3742], '(41.Renkema': [3743], 'G.H.': [3744], 'Boot': [3745], 'R.G.': [3746], 'Au': [3747], 'F.L.': [3748], 'Donker-Koopman': [3749], 'Strijland': [3751], 'Muijsers': [3753], 'A.O.': [3754], 'Hrebicek': [3755], 'Aerts': [3757], 'J.M.F.G.': [3758], 'Eur.': [3759], 'Biochem.': [3761, 4460], '251:': [3763], '504-509Crossref': [3764], '(331)': [3767], 'contrast,': [3782], 'formation': [3790], 'plants': [3802], 'bacteria.': [3804], 'enzymes,': [3808], 'loops': [3809, 4141], 'C': [3813, 4135], 'termini': [3814, 4136], 'portion': [3818], '(loops': [3821], 'βXαX,': [3822, 4142], 'X': [3823], 'being': [3824], 'number': [3826], 'barrel)': [3832], 'usually': [3834, 4206], 'interactions': [3837], 'loops,': [3845], 'fairly': [3847], 'composition,': [3854], 'conserve': [3855], 'key': [3857, 4165], 'responsible': [3859], 'catalysis': [3861], 'true': [3887], 'seen': [3897, 4251], '3.': [3900], 'Loop': [3901], 'β4α4': [3902, 3942], '131–165)': [3904], 'distinctly': [3906], 'long': [3907], 'family.': [3911], 'neither': [3913], 'our': [3915, 4089], 'Ile-161,': [3925], 'location': [3927], 'boundary': [3930], 'should': [3944], 'fully': [3946], 'exposed': [3947], 'solvent.': [3949], 'Furthermore,': [3950], 'appears': [3953], 'undergone': [3956], 'proteolytic': [3957], 'cleavage.': [3958, 4073], 'SDS-PAGE': [3960], 'redissolved': [3969], 'crystals,': [3970], 'revealed': [3971], 'faint': [3974], 'band': [3975, 4013, 4043], '47': [3977], 'kDa': [3978, 3996], '(the': [3979], 'expected': [3980], 'mass': [3982], 'intact': [3985, 4108], 'protein),': [3986], 'along': [3987], 'prominent': [3990], 'bands': [3991], '29': [3995], 'together': [3998], 'represented': [3999], '>90%': [4000], 'total': [4003], '(data': [4005], 'shown).': [4007], 'sequencing': [4009], '18-kDa': [4012], 'gave': [4014], 'ASNLV': [4017], 'XYYDSS': [4018], 'XYTREGLGK,': [4019], 'corresponding': [4020, 4238], 'N': [4024], 'terminus': [4025], 'following': [4026], 'removal': [4027], 'signal': [4030], 'during': [4032, 4168], 'secretion': [4033], 'mature': [4035], '29-kDa': [4042], 'yielded': [4044], 'TGDFIVDPHAALHKEQ,': [4047], 'implying': [4048], 'nick': [4050], 'Phe-156': [4052], 'Thr-157.': [4054], '131–165': [4065], 'reflect': [4068], 'disorder': [4069], 'It': [4074], 'possible': [4077], '142–160': [4084], 'excised': [4087], 'preparations.': [4090], 'Importantly,': [4091], 'cleaved': [4092], 'uncleaved': [4094], 'display': [4096], 'comparable': [4097], 'assays,': [4104], 'demonstrating': [4105], '131–145': [4109], 'function.': [4116], '2P.': [4117], 'Bryant,': [4119], 'personal': [4120], 'communication.': [4121], 'situated': [4128], 'cleft': [4131], 'β-strands': [4139], 'presents': [4144], '4B).': [4154], 'residue': [4157, 4239], '(e.g.': [4158], 'Glu-315': [4159], 'A)': [4162], 'proton': [4166], 'donor': [4167], 'glycosidic': [4172], '(42.Lin': [4174], 'F.-P.': [4175, 4393], 'H.-C.': [4177, 4395], 'Lin': [4178, 4396], 'C.-S.': [4179, 4397], 'IUBMB': [4180, 4398], 'Life.': [4181, 4399], '48:': [4183, 4401], '199-204Crossref': [4184, 4402], '43.McCarter': [4188], 'Withers': [4190], 'S.G.': [4191], '4:': [4197], '885-892Crossref': [4198], '(797)': [4201], 'imbedded': [4207], 'hydrophobic': [4210], 'contributes': [4213], 'binding,': [4216], 'facilitating': [4222], 'Glu.': [4229], 'Gln-132': [4241, 4475], '3,': [4243], 'blue': [4244], 'star;': [4245], '4A).': [4247], 'substitution': [4249], '3)': [4262], '34.Hennig': [4285], '44.Jin': [4308], 'H.M.': [4309], 'Copeland': [4310], 'N.G.': [4311], 'Gilbert': [4312], 'D.J.': [4313], 'Jenkins': [4314], 'N.A.': [4315], 'Kirkpatrick': [4316], 'Genomics.': [4320], '316-322Crossref': [4323], '(70)': [4326], '45.Watanabe': [4329, 4406], 'Kobori': [4331, 4408], 'Miyashita': [4333, 4410], 'Fujii': [4335, 4412], 'Sakai': [4337, 4414], 'Uchida': [4339, 4416], 'Tanaka': [4341, 4418], '18567-18572Abstract': [4348, 4425], 'example': [4356], '4C),': [4359], '42.Lin': [4392], 'H,': [4437], 'hydrolase': [4442], '(46.Schmidt': [4443], 'B.F.': [4444], 'Ashizawa': [4445], 'Jarnagin': [4447], 'A.S.': [4448], 'Lynn': [4449], 'Noto': [4451], 'Woodhouse': [4453], 'L.': [4454], 'Estell': [4455], 'D.A.': [4456], 'Lad': [4457], 'Arch.': [4459], 'Biophys.': [4461], '311:': [4463], '350-353Crossref': [4464], '(16)': [4467], 'side': [4472], 'oriented': [4479], 'differently': [4480], 'ca': [4485]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2069502744', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2023, 'cited_by_count': 1}, {'year': 2022, 'cited_by_count': 5}, {'year': 2021, 'cited_by_count': 2}, {'year': 2020, 'cited_by_count': 9}, {'year': 2019, 'cited_by_count': 6}, {'year': 2018, 'cited_by_count': 1}, {'year': 2017, 'cited_by_count': 2}, {'year': 2016, 'cited_by_count': 1}, {'year': 2015, 'cited_by_count': 4}, {'year': 2014, 'cited_by_count': 4}, {'year': 2013, 'cited_by_count': 3}, {'year': 2012, 'cited_by_count': 6}], 'updated_date': '2024-12-14T16:47:45.991044', 'created_date': '2016-06-24'}
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