Title: Mucosal Tolerance to Experimental Autoimmune Myasthenia Gravis Is Associated with Down‐regulation of AChR‐specific IFN‐γ‐expressing Th1‐like Cells and Up‐regulation of TGF‐β mRNA in Mononuclear Cells
Abstract: Annals of the New York Academy of SciencesVolume 778, Issue 1 p. 273-287 Mucosal Tolerance to Experimental Autoimmune Myasthenia Gravis Is Associated with Down-regulation of AChR-specific IFN-γ-expressing Th1-like Cells and Up-regulation of TGF-β mRNA in Mononuclear Cells CUN-GEN MA, CUN-GEN MA Division of Neurology Karolinska Institute Huddinge University Hospital S-141 86 Huddinge, SwedenSearch for more papers by this authorGUANG-XIAN ZHANG, GUANG-XIAN ZHANG Division of Neurology Karolinska Institute Huddinge University Hospital S-141 86 Huddinge, SwedenSearch for more papers by this authorBAO-GUO XIAO, BAO-GUO XIAO Division of Neurology Karolinska Institute Huddinge University Hospital S-141 86 Huddinge, SwedenSearch for more papers by this authorZENG-YU WANG, ZENG-YU WANG Division of Neurology Karolinska Institute Huddinge University Hospital S-141 86 Huddinge, SwedenSearch for more papers by this authorJOANNE LINK, JOANNE LINK Division of Neurology Karolinska Institute Huddinge University Hospital S-141 86 Huddinge, SwedenSearch for more papers by this authorTOMAS OLSSON, TOMAS OLSSON Division of Neurology Karolinska Institute Huddinge University Hospital S-141 86 Huddinge, SwedenSearch for more papers by this authorHANS LINK, HANS LINK Division of Neurology Karolinska Institute Huddinge University Hospital S-141 86 Huddinge, SwedenSearch for more papers by this author CUN-GEN MA, CUN-GEN MA Division of Neurology Karolinska Institute Huddinge University Hospital S-141 86 Huddinge, SwedenSearch for more papers by this authorGUANG-XIAN ZHANG, GUANG-XIAN ZHANG Division of Neurology Karolinska Institute Huddinge University Hospital S-141 86 Huddinge, SwedenSearch for more papers by this authorBAO-GUO XIAO, BAO-GUO XIAO Division of Neurology Karolinska Institute Huddinge University Hospital S-141 86 Huddinge, SwedenSearch for more papers by this authorZENG-YU WANG, ZENG-YU WANG Division of Neurology Karolinska Institute Huddinge University Hospital S-141 86 Huddinge, SwedenSearch for more papers by this authorJOANNE LINK, JOANNE LINK Division of Neurology Karolinska Institute Huddinge University Hospital S-141 86 Huddinge, SwedenSearch for more papers by this authorTOMAS OLSSON, TOMAS OLSSON Division of Neurology Karolinska Institute Huddinge University Hospital S-141 86 Huddinge, SwedenSearch for more papers by this authorHANS LINK, HANS LINK Division of Neurology Karolinska Institute Huddinge University Hospital S-141 86 Huddinge, SwedenSearch for more papers by this author First published: February 1996 https://doi.org/10.1111/j.1749-6632.1996.tb21135.xCitations: 33AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat REFERENCES 1 Lindstrom, J., D. Shelton & Y. Fujii. 1988. Myasthenia gravis. Adv. Immunol. 42: 233. 2 Drachman, D. B. 1994. Myasthenia gravis. N. Engl. J. Med. 330: 1797. 3 Hohlfeld, R., I. Kalies, B. Kohleisen, K. Heininger, B. Conti-Tronconi & K. V. Toyka. 1986. Myasthenia gravis: stimulation of antireceptor autoantibodies by autoreactive T cell lines. Neurology 36: 618. 4 Bach, J. F. 1993. Immunosuppressive therapy of autoimmune diseases. Immunol. Today 14: 322. 5 Drachman, D. B., K. R. McIntosh, S. De Silva, R. W. Kuncl & C. Kahn. 1988. Strategies for the treatment of myasthenia gravis. Ann. N.Y. Acad. Sci. 540: 176–186. 6 Weiner, H. L., A. Friedman, A. Miller, S. J. Khoury, A. Al-Sabbagh, L. Santos, M. Sayegh, R. B. Nussenblatt, D. A. Trentham & D. A. Hafler. 1994. Oral tolerance: Immunologic mechanisms and treatment of murine and human organ specific autoimmune diseases by oral administration of autoantigens. Annu. Rev. Immunol. 12: 809. 7 Dick, A. D., Y. F. Cheng, A. McKinnon, J. Liversidge & J. V. Forrester. 1993. Nasal administration of retinal antigens suppresses the inflammatory response in experimental allergic uveoretinitis. A preliminary report of intranasal induction of tolerance with retinal antigens. Br. J. Ophthalmol. 77: 171. 8 Link, J., M. Söderström, Å. Ljungdahl, B. Höjeberg, T. Olsson, Z. Xu, S. Fredrikson, Z. Y. Wang & H. Link. 1994. Organ-specific autoantigans induce IFN-γ and IL-mRNA expression in mononuclear cells in multiple sclerosis and myasthenia gravis. Neurology 44: 728. 9 Miller, A., O. Lider, A. B. Roberts, M. B. Spron & H. L. Weiner. 1992. Suppressor T cells generated by oral tolerization to myelin basic protein suppress both in vitro and in vivo immune responses by the release of transforming growth factor β following antigen-specific triggering. Proc. Natl. Acad. Sci. USA 89: 421. 10 Simmons, R. D. & D. O. Willenborg. 1990. Direct injection of cytokines into the spinal cord causes autoimmune encephalomyelitis-like inflammation. J. Neurol. Sci. 100: 37. 11 Mustafa, M. I., P. Diener, B. Höjeberg, P. van der Meide & T. Olsson. 1991. T cell immunity and interferon-γ secretion during experimental allergic encephalomyelitis in Lewis rats. J. Neuroimmunol. 31: 165. 12 Link, H., O. Olsson, J. B. Sun, W. Z. Wang, G. Andersson, H. P. Ekre, T. Brenner, O. Abramsky & T. Olsson. 1991. Acetylcholine receptor-reactive T and B cells in myasthenia gravis and controls. J. Clin. Invest. 87: 2191. 13 Hamel, C. P., B. Detrick, & J. J. Hooks. 1990. Evaluation of Ia expression in rat ovular tissues following inoculation with interferon-gamma. Exp. Eye Res. 50: 173. 14 Schattner, A. 1994. Lymphokines in autoimmunity – a critical review. Clin. Immunol. Immunopathol. 70: 177. 15 Gu, D., L. Wogensen, N. A. Calcutt, G. Xia, S. Zhu, J. P. Merlie, H. S. Fox, J. Lindstrom, H. C. Powell & N. Sarvetnick. 1995. Myasthenia gravis-like syndrome induced by expression of interferon γ in the neuromuscular junction. J. Exp. Med. 181: 547. 16 Skoskiewicz, M. H., R. B. Callin, E. E. Sternberger & P. S. Russel. 1985. Widespread and selective induction of major histocompatibility complex determined antigens in vivo by γ interferon. J. Exp. Med. 162: 1645. 17 Sidman, C. L., J. D. Maxwell, L. D. Schultz, W. P. Gray & H. M. Johnson. 1984. γ-Interferon is one of several direct B cell-maturing lymphokines. Nature 309: 801. 18 Collart, M. A., J. Belin, D. Vassalli, S. de Kossodo & P. Vassalli. 1986. Gamma-interferon enhances macrophage transcription of the tumor necrosis factor/cachectin, interleukin-1, and urokinase genes, which are controlled by short-lived repressors. J. Exp. Med. 164: 2113. 19 Nakano, S. & A. G. Engel. 1993. Myasthenia gravis: quantitative immunocytochemical analysis of inflammatory cells and detection of complement membraane attack complex at the end-plate in 30 pattients. Neurology 43: 1167. 20 Finkelman, F. D. & J. Holmes. 1990. Lymphokine control of in vivo immunoglobulin isotype selection. Annu. Rev. Immunol. 8: 303. 21 Link, J., V. Navikas, M. Yu, S. Fredrikson, P. O. Osterman & H. Link. 1994. Augmented interferon-γ, interleukin-4 and transforming growth factor-β mRNA expression in blood mononuclear cells in myasthenia gravis. J. Neuroimmunol. 51: 185. 22 Sasaki, H., R. B. Pollard, D. Schmitt & F. Suzuki. 1992. Transforming growth factor-β in the regulation of the immune response. Clin. Immunol. Immunopathol. 65: 1. 23 Kehrl, J. H., C. Thevenin, P. Rieckmann & A. S. Fauci. 1991. Transforming growth factor-β suppresses human B lymphocyte Ig production by inhibiting synthesis and the switch from the membrane form to the secreted form of Ig mRNA. J. Immunol. 146: 4016. 24 Kehrl, J. H., L. D. Wakefield, A. B. Roberts, S. Jakowlew, M. Alvarez-Mon, R. Derynck, M. B. Sporn & A. S. Fauci. 986. Production of transforming growth factor β by human T lymphocytes and its potential role in the regulation of T cell growth. J. Exp. Med. 163: 1037. 25 Stevens, D. B., K. E. Gould & R. H. Swanborg. 1994. ransforming growth factor β1 inhibits tumor necrosis factor-α/lymphotoxin production and adoptive transfer of disease by effector cells of autoimmune encephalomyelitis. J. Neuroimmunol. 51: 77. 26 Kim, K. J., J. Abrams & M. Alphonso. 1990. Role of endogenously produced interleukin-6 as a second signal in murine thymocyte proliferation induced by multiple cytokines: regulatory effects of transforming growth factor-β1. Cell. Immunol. 131: 261. 27 Czarniecki, C. W., H. H. Chiu, G. W. Wong, S. M. McCabe & M. A. Palladino. 1988. Transforming growth factor-β 1 modulates the expression of class II histocompatibility antigens on human cells. J. Immunol. 140: 4217. 28 Gamble, J. R. & M. A. Vadas. 1991. Endothelial cell adhesiveness for human T lymphocytes is inhibited by transforming growth factor-β. J. Immunol. 146: 1149. 29 Link, J., S. Fredrikson, M. Söderström, T. Olsson, B. Höjeberg, Å. Ljungdahl & H. Link. 1994. Organ-specific autoantigens induce transforming growth factor-β mRNA expression in mononuclear cells in multiple sclerosis and myasthenia gravis. Ann. Neurol. 35: 197. 30 Link, J., B. He, V. Navikas, W. Palasik, S. Fredriskon, M. Söderström & H. Link. 1995. TGF-β1 suppresses autoantigen-induced expression of proinflammatory cytokines but not IL-10 in multiple sclerosis and myasthenia gravis. J. Neuroimmunol. 58: 21. Citing Literature Volume778, Issue1Oral Tolerance: Mechanisms and ApplicationsFebruary 1996Pages 273-287 ReferencesRelatedInformation
Publication Year: 1996
Publication Date: 1996-02-01
Language: en
Type: article
Indexed In: ['crossref', 'pubmed']
Access and Citation
Cited By Count: 40
AI Researcher Chatbot
Get quick answers to your questions about the article from our AI researcher chatbot