Title: An oxygen dependent current in Aplysia neurons: An approach to the question of cellular hypoxic adaptation
Abstract: Specimens of Aplysia californica and Aplysia dactylomela were exposed to seawater of Po2 20–40 torr for 15–25 hr. Abdominal ganglia from both normoxic and hypoxic animals were monitored by recording membrane potential and by voltage clamping while oxygen concentration was varied. These neurons exhibited an oxygen-dependent outward membrane current that was found to represent activity of the sodium-potassium pump. Clamp-current response could be plotted reproducibly as a function of Po2. Although the response of the hypoxic animals did not differ significantly from that of the normoxic animals, the technique appeared sufficiently accurate that it might be useful as a measure of cellular hypoxic adaptation in more rapidly metabolizing neurons.
Publication Year: 1975
Publication Date: 1975-01-01
Language: en
Type: article
Indexed In: ['crossref', 'pubmed']
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Cited By Count: 5
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