Caspase-10 Triggers Bid Cleavage and Caspase Cascade Activation in FasL-induced Apoptosis

Name: Work Video:
Duration: 3 min 30 s
Delphine Milhas; Olivier Cuvillier; Nicole Therville; Père Clavé; Mogens Thomsen; Thierry Levade; Hervé Benoist; Bruno Ségui
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'https://openalex.org/W1836073275', 'https://openalex.org/W1942214720', 'https://openalex.org/W1969893319', 'https://openalex.org/W1973109581', 'https://openalex.org/W1986308149', 'https://openalex.org/W1988728998', 'https://openalex.org/W1992637685', 'https://openalex.org/W1993129579', 'https://openalex.org/W1996345468', 'https://openalex.org/W2002323638', 'https://openalex.org/W2012173926', 'https://openalex.org/W2025044046', 'https://openalex.org/W2026057304', 'https://openalex.org/W2036505974', 'https://openalex.org/W2056641170', 'https://openalex.org/W2060925403', 'https://openalex.org/W2062853648', 'https://openalex.org/W2065540065', 'https://openalex.org/W2073028327', 'https://openalex.org/W2075882509', 'https://openalex.org/W2076807689', 'https://openalex.org/W2077705257', 'https://openalex.org/W2089244519', 'https://openalex.org/W2094334993', 'https://openalex.org/W2098593116', 'https://openalex.org/W2106763550', 'https://openalex.org/W2108307486', 'https://openalex.org/W2119683782', 'https://openalex.org/W2124925407', 'https://openalex.org/W2157600252', 'https://openalex.org/W2162618482'], 'related_works': ['https://openalex.org/W3200167435', 'https://openalex.org/W3149175423', 'https://openalex.org/W2139617193', 'https://openalex.org/W2090184034', 'https://openalex.org/W2058773384', 'https://openalex.org/W2048157470', 'https://openalex.org/W2045923190', 'https://openalex.org/W2031744872', 'https://openalex.org/W1979154669', 'https://openalex.org/W1976473462'], 'abstract_inverted_index': {'In': [0, 110, 152, 193, 303, 345, 565, 1139, 1273, 1328, 1459, 1834, 1910, 2194, 3327, 4145, 4344], 'contrast': [1, 194, 566, 1460, 1493], 'to': [2, 7, 12, 17, 122, 162, 185, 195, 200, 205, 210, 315, 355, 378, 405, 567, 797, 1137, 1217, 1289, 1461, 1494, 1543, 1551, 1586, 1677, 1848, 1872, 1890, 1935, 2069, 2256, 2530, 2572, 2875, 2919, 3009, 3079, 3249, 3303, 3544, 3630, 3935, 3980, 4065, 4104, 4126, 4168, 4210, 4229, 4236, 4279, 4285, 4330, 4371], 'caspase-8,': [3, 158, 196, 351, 1331, 1931], 'controversy': [4, 197], 'exists': [5, 198], 'as': [6, 29, 31, 54, 155, 157, 177, 199, 222, 224, 247, 348, 350, 370, 409, 723, 1597, 1879, 1881, 2825, 3421, 3449, 3526, 3875, 3877, 3911, 3913, 3926], 'the': [8, 103, 201, 296, 393, 400, 414, 426, 630, 1148, 1225, 1285, 1290, 1340, 1344, 1681, 1724, 1842, 1916, 1938, 1947, 2096, 2430, 2511, 2519, 2555, 2618, 2648, 2696, 2810, 2979, 3007, 3096, 3105, 3229, 3315, 3408, 3464, 3495, 3500, 3514, 3634, 3809, 3827, 3866, 3929, 3997, 4013, 4041, 4050, 4113, 4223, 4311, 4362, 4381], 'ability': [9, 202], 'of': [10, 24, 105, 112, 203, 217, 298, 305, 395, 399, 416, 428, 474, 505, 519, 530, 533, 585, 624, 629, 634, 657, 792, 800, 890, 1147, 1202, 1292, 1726, 1734, 1865, 1925, 1937, 1946, 2098, 2239, 2261, 2288, 2327, 2474, 2513, 2521, 2540, 2543, 2568, 2581, 2620, 2623, 2633, 2636, 2653, 2737, 2823, 2856, 2989, 3011, 3216, 3220, 3233, 3292, 3296, 3322, 3390, 3398, 3402, 3410, 3435, 3499, 3518, 3538, 3561, 3601, 3766, 3795, 3811, 3819, 3829, 3868, 3894, 3916, 3931, 3984, 4015, 4045, 4059, 4080, 4091, 4121, 4139, 4151, 4212, 4383], 'caspase-10': [11, 84, 117, 126, 143, 174, 204, 277, 310, 319, 336, 367, 1332, 1364, 1673, 1727, 1735, 1845, 1894, 1900, 1932, 3626, 3699, 3796, 3832, 3903, 4019, 4185, 4202, 4240, 4274, 4372, 4384, 4403], 'mediate': [13, 206], 'apoptosis': [14, 207, 481, 1547, 1864, 2881, 3243, 3925], 'in': [15, 42, 100, 139, 147, 181, 208, 235, 293, 332, 340, 374, 392, 432, 647, 1492, 1501, 1549, 1593, 1684, 1692, 1728, 1739, 1743, 1810, 1841, 1896, 2095, 2184, 2202, 2210, 2293, 2298, 2335, 2437, 2510, 2536, 2617, 2629, 2746, 2867, 2878, 2917, 3001, 3084, 3124, 3127, 3228, 3261, 3266, 3283, 3301, 3324, 3371, 3407, 3481, 3494, 3513, 3583, 3589, 3608, 3636, 3770, 3776, 3785, 3799, 3808, 4012, 4023, 4031, 4040, 4110, 4204, 4227, 4297, 4302, 4310, 4327, 4334, 4353, 4361], 'response': [16, 209, 1550, 2918, 3302, 4228], 'FasL.': [18, 49, 211, 242, 2137, 3792, 4127], 'Herein,': [19, 212, 1856, 2994], 'we': [20, 213, 1857, 2995, 3005, 3697, 3825], 'have': [21, 214, 477, 595, 769, 1367, 1467, 1858, 2909, 2996], 'shown': [22, 215, 1542, 1859, 2911], 'activation': [23, 216, 656, 962, 1291, 1592, 1936, 3377, 3477, 3588, 3879, 3965, 4309], 'caspase-10,': [25, 154, 218, 347, 1495, 1874, 1926, 3869], '-3,': [26, 219, 1875, 3552], 'and': [27, 38, 58, 78, 134, 191, 220, 231, 251, 271, 327, 384, 419, 421, 453, 485, 512, 517, 524, 542, 581, 591, 627, 660, 822, 867, 960, 1133, 1219, 1277, 1296, 1339, 1435, 1465, 1469, 1477, 1488, 1536, 1538, 1632, 1678, 1851, 1876, 1884, 1908, 1955, 1965, 1983, 2032, 2041, 2062, 2078, 2135, 2143, 2159, 2188, 2221, 2227, 2273, 2296, 2321, 2361, 2374, 2482, 2574, 2661, 2680, 2688, 2695, 2727, 2785, 2805, 3018, 3071, 3086, 3196, 3209, 3257, 3383, 3412, 3428, 3446, 3478, 3522, 3529, 3535, 3546, 3580, 3604, 3631, 3797, 3871, 3883, 3904, 3906, 3955, 4007, 4017, 4056, 4067, 4135, 4142, 4172, 4176, 4180, 4182, 4190, 4195, 4214, 4245, 4257, 4259, 4323, 4336, 4355, 4385, 4391, 4396], '-7': [28, 221, 1877, 3905], 'well': [30, 156, 223, 349, 1880, 3876], 'B': [32, 225, 904, 1149, 1206, 4395], 'cell': [33, 91, 120, 226, 284, 313, 475, 483, 547, 573, 587, 593, 618, 651, 717, 905, 1150, 1207, 2161, 2217, 2232, 2914, 2984, 2999, 3023, 3098, 3106, 3363, 3417, 3469, 4163, 4364], 'lymphoma-2-interacting': [34, 227, 906], 'domain': [35, 228], '(Bid)': [36, 229], 'cleavage': [37, 230, 1883, 2701, 4325], 'cytochrome': [39, 232, 1221, 1282, 1581, 1853, 1885, 3969, 3985, 4008, 4028], 'c': [40, 233, 1222, 1283, 1582, 1854, 1886, 1978, 3578, 3943, 3970, 3986, 4009, 4029], 'release': [41, 234, 1223, 1583, 4010, 4030], 'caspase-8-deficient': [43, 236, 1866, 1897, 3015, 3186, 3221, 3267, 3372, 3482, 3486, 3505, 4032], 'Jurkat': [44, 237, 1503, 1530, 1594, 1686, 1741, 1867, 2153, 2869, 2880, 3002, 3022, 3263, 3483, 3487, 3506, 3585, 3637, 4033, 4036], '(I9-2)': [45, 238], 'cells': [46, 114, 140, 239, 307, 333, 1504, 1533, 1600, 1742, 2100, 2156, 2199, 2240, 2264, 2290, 2329, 2334, 2422, 2507, 2738, 2824, 3126, 3187, 3222, 3239, 3268, 3373, 3403, 3488, 3507, 3531, 3591, 3610, 3638, 3772, 3787, 3801, 3896, 3933, 4037, 4082, 4123, 4132, 4153, 4207, 4216, 4247, 4253, 4261, 4269, 4281, 4289, 4314, 4338], 'treated': [47, 240, 3788, 3802, 4339], 'with': [48, 102, 125, 141, 149, 241, 295, 318, 334, 342, 915, 1275, 1330, 1893, 2103, 2133, 2247, 2267, 2317, 2355, 2666, 2682, 3129, 3192, 3329, 3549, 3615, 3774, 3789, 3803, 3898, 3918, 4070, 4107, 4239, 4340, 4380], 'Apoptosis': [50, 243, 498, 2866], 'was': [51, 93, 244, 286, 1584, 1870, 1999, 2015, 2025, 2052, 2085, 2108, 2235, 2337, 2427, 2457, 2559, 2615, 3074, 3184, 3269, 3311, 3365, 3378, 3419, 3466, 3592, 3606, 3805, 3945, 4208, 4359, 4368, 4386], 'clearly': [52, 245, 479, 3768], 'induced': [53, 246], 'illustrated': [55, 248, 3450], 'by': [56, 65, 97, 249, 258, 290, 502, 538, 576, 638, 732, 794, 2175, 2339, 2429, 2470, 2518, 2561, 2663, 2809, 3076, 3272, 3314, 3369, 3423, 3451, 3595, 3928, 4085, 4389], 'nuclear': [57, 250, 515, 3197, 3440, 3444, 3472], 'DNA': [59, 135, 252, 328, 525, 2331, 3299, 3325], 'fragmentation.': [60, 253, 3326], 'These': [61, 254], 'events': [62, 255], 'were': [63, 76, 137, 256, 269, 330, 1690, 1959, 1990, 2035, 2072, 2131, 2147, 2172, 2182, 2200, 2219, 2265, 2291, 2308, 2343, 2353, 2423, 2435, 2464, 2508, 2570, 2655, 2675, 2739, 2790, 2803, 2817, 2858, 3121, 3223, 3404, 3489, 3508, 3532, 3542, 3908, 4038, 4054, 4063, 4083, 4124, 4133, 4159, 4254, 4282, 4347, 4350], 'inhibited': [64, 257, 3380, 3865], 'benzyloxycarbonyl-VAD-fluoromethyl': [66, 259], 'ketone,': [67, 82, 260, 275], 'a': [68, 83, 87, 106, 261, 276, 280, 299, 644, 774, 1144, 1205, 1922, 2000, 2104, 2346, 2377, 2537, 2630, 2747, 2987, 3113, 3178, 3330, 3388, 3702, 3777, 3815, 3831, 3923, 3937, 4137, 4306, 4331, 4407], 'broad': [69, 262], 'spectrum': [70, 263], 'caspase': [71, 98, 130, 180, 188, 264, 291, 323, 373, 381, 1590, 1905, 2625, 2700, 3317, 3376, 3476, 3964, 4003, 4308], 'inhibitor,': [72, 85, 265, 278], 'indicating': [73, 266, 1928, 3320], 'that': [74, 173, 267, 366, 540, 1294, 1481, 1671, 1844, 1860, 1919, 2912, 2981, 3095, 3205, 3437, 3902, 3962, 3999, 4018, 4117, 4130, 4211, 4270, 4402], 'caspases': [75, 268, 539, 1026, 1031, 1130, 1299, 3323, 4346], 'functionally': [77, 270], 'actively': [79, 272], 'involved.': [80, 273], 'Benzyloxycarbonyl-AEVD-fluoromethyl': [81, 274], 'had': [86, 279], 'comparable': [88, 281, 4188], 'effect.': [89, 282], 'FasL-induced': [90, 283, 3242, 3461, 4250, 4295, 4377], 'death': [92, 285, 387, 417, 429, 476, 574, 619, 718, 909, 916, 2915, 2985, 3000, 3364, 3470], 'not': [94, 146, 287, 339, 1809, 3280, 3366, 3385, 3443, 3881, 3967, 3976, 4218, 4232, 4272, 4301, 4316, 4321, 4348], 'completely': [95, 288, 3240, 3312, 3379, 3806], 'abolished': [96, 289, 3313, 3807], 'inhibitors': [99, 292], 'agreement': [101, 294, 3128], 'existence': [104, 297], 'cytotoxic': [107, 300, 728], 'caspase-independent': [108, 301], 'pathway.': [109, 302, 1940], 'subpopulations': [111, 304, 4150, 4224], 'I9-2': [113, 306, 2198, 2506, 3085, 3590, 3609, 3771, 3786, 3800, 3895, 4111, 4122, 4131, 4152, 4205], 'displaying': [115, 308], 'distinct': [116, 309, 4166], 'expression': [118, 311, 1895, 2234, 3073, 3103, 3700, 4197, 4203], 'levels,': [119, 312], 'sensitivity': [121, 314, 1889, 3008, 4167, 4235], 'FasL': [123, 316, 639, 795, 1861, 1891, 2084, 2093, 2107, 2863, 2921, 3010, 3115, 3180, 3254, 3278, 3306, 3413, 3502, 3521, 3573, 3616, 3804, 3919, 4000, 4048, 4105, 4169, 4237, 4286, 4341], 'correlated': [124, 317, 1892, 4238, 4379], 'expression.': [127, 320], 'A': [128, 321, 1899, 3528, 3890], 'robust': [129, 322], 'activation,': [131, 190, 324, 383, 1878, 1907, 4004], 'Bid': [132, 161, 166, 186, 325, 354, 359, 379, 1203, 1850, 1882, 1903, 1920, 2585, 2690, 3479, 3575, 3781, 3798, 4005, 4367, 4406], 'cleavage,': [133, 326], 'fragmentation': [136, 329, 526, 3198, 3265, 3300], 'observed': [138, 331, 3607, 3947], 'high': [142, 335, 2920, 4183, 4312], 'levels': [144, 337, 4186], 'but': [145, 338, 727, 1808, 3442, 3463, 3948, 4187, 4275, 4300], 'those': [148, 341], 'low': [150, 343, 3114, 3982, 4174], 'levels.': [151, 344], 'vitro,': [153, 346], 'could': [159, 352, 1674], 'cleave': [160, 353, 541, 1132, 1498, 1849, 4405], 'generate': [163, 356], 'active': [164, 357], 'truncated': [165, 358, 1214], '(p15).': [167, 360], 'Altogether,': [168, 361, 4398], 'our': [169, 362, 3973, 3993, 4399], 'data': [170, 363, 2130, 3384, 3994, 4400], 'strongly': [171, 364, 1927, 3813, 3995, 4248, 4387], 'suggest': [172, 365, 1480], 'can': [175, 368, 403, 499, 1027, 1497, 1862, 1933, 3627, 4001, 4404], 'serve': [176, 369], 'an': [178, 371, 389, 571, 724, 2252, 2486, 3189, 4263], 'initiator': [179, 372, 823, 1280], 'Fas': [182, 375, 635, 653, 793, 1552, 1696, 1729, 3102], 'signaling': [183, 376, 729, 901, 932, 1730], 'leading': [184, 377, 1136, 1288], 'processing,': [187, 380, 1904, 4006], 'cascade': [189, 382, 1591, 1906], 'apoptosis.': [192, 385, 531, 1138, 1909, 2993], 'Cell': [386, 706, 1888, 2038, 2151, 2605, 2966, 3062, 3169, 3259], 'is': [388, 570, 620, 1837, 1846, 1913, 1921, 2986, 3434, 4020], 'essential': [390, 545, 621, 1545, 2877], 'process': [391, 3310], 'regulation': [394], 'cellular': [396, 511, 3194], 'homeostasis.': [397], 'Dysfunction': [398], 'mechanisms': [401], 'involved': [402, 4022], 'lead': [404, 1934], 'human': [406, 2136, 2689], 'diseases': [407, 412, 424], 'such': [408], 'cancers,': [410], 'autoimmune': [411], '(in': [413, 425], 'case': [415, 427], 'defect),': [418], 'neurodegenerative': [420], 'immune': [422, 631], 'deficiency': [423, 1738, 3083], 'excess)': [430], '(reviewed': [431], 'Refs.': [433], '1Bellamy': [434], 'C.O.': [435], 'Malcomson': [436], 'R.D.': [437], 'Harrison': [438], 'D.J.': [439], 'Wyllie': [440], 'A.H.': [441], 'Semin.': [442], 'Cancer': [443], 'Biol.': [444, 707, 874, 1010, 1076, 1112, 1419, 1444, 1563, 1655, 1768, 2404, 2606, 2835, 2891, 2967, 3034, 3141, 3660, 3727, 3847], '1995;': [445, 811, 950], '6:': [446], '3-16Crossref': [447], 'PubMed': [448, 467, 493, 560, 612, 688, 711, 762, 786, 817, 862, 884, 953, 1000, 1020, 1064, 1086, 1122, 1170, 1194, 1244, 1268, 1323, 1355, 1404, 1429, 1454, 1525, 1572, 1624, 1665, 1718, 1778, 1803, 1829, 2414, 2610, 2720, 2845, 2900, 2948, 2971, 3043, 3150, 3358, 3670, 3692, 3737, 3759, 3857], 'Scopus': [449, 468, 494, 561, 613, 689, 712, 763, 787, 818, 863, 885, 954, 1001, 1021, 1065, 1087, 1123, 1171, 1195, 1245, 1269, 1324, 1356, 1405, 1430, 1455, 1526, 1573, 1625, 1666, 1719, 1779, 1804, 1830, 2415, 2611, 2721, 2846, 2901, 2949, 2972, 3044, 3151, 3359, 3671, 3693, 3738, 3760, 3858], '(234)': [450], 'Google': [451, 470, 496, 563, 615, 691, 714, 765, 789, 820, 865, 887, 956, 1003, 1023, 1067, 1089, 1125, 1173, 1197, 1247, 1271, 1326, 1358, 1407, 1432, 1457, 1528, 1575, 1627, 1668, 1721, 1781, 1806, 1832, 2127, 2417, 2613, 2723, 2848, 2903, 2951, 2974, 3046, 3068, 3153, 3175, 3361, 3673, 3695, 3740, 3762, 3860], 'Scholar': [452], '2Fadeel': [454], 'B.': [455, 459, 680, 754, 2382, 2601, 2940, 3350], 'Orrenius': [456], 'S.': [457, 674, 704, 748, 937, 1059, 1399, 1520, 1604, 1713, 1798, 2386, 2587, 2595, 2597, 2833, 2934, 2964, 3344], 'Zhivotovsky': [458], 'Biochem.': [460, 555, 1350], 'Biophys.': [461], 'Res.': [462], 'Commun.': [463], '1999;': [464, 1446, 2124, 2406, 2607, 3065, 3172], '266:': [465], '699-717Crossref': [466], '(213)': [469], 'Scholar).': [471, 497, 564, 616, 715, 766, 790, 888, 1024, 1126, 1198, 1272, 1327, 1359, 1458, 1529, 1576, 1628, 1722, 1833, 2128, 2418, 2724, 2849, 2904, 2975, 3069, 3176, 3763, 3861], 'Two': [472], 'types': [473], 'been': [478, 596, 770, 1368, 1541, 2873], 'distinguished,': [480], '(programmed': [482], 'death)': [484], 'necrosis': [486, 569, 2990], '(3Wyllie': [487], 'A.': [488, 672, 700, 746, 780, 834, 972, 1060, 1096, 1100, 1104, 1110, 1400, 1521, 1606, 1639, 1643, 1647, 1653, 1714, 1752, 1756, 1760, 1766, 1799, 1819, 2113, 2121, 2589, 2591, 2932, 2960, 3342, 3644, 3648, 3652, 3658, 3682, 3711, 3715, 3719, 3725, 3749, 3843], 'Nature.': [489], '1998;': [490, 1162, 1186, 1236, 1260, 1564, 1621, 2712, 2892, 3035, 3142], '391:': [491], '20-21Crossref': [492], '(53)': [495], 'be': [500, 1544, 1587, 1675, 2876, 3628, 3977], 'characterized': [501, 575], 'typical': [503], 'sets': [504], 'changes': [506], 'including': [507], 'plasma': [508, 578], 'membrane': [509, 579, 3447], 'blebbing,': [510], 'chromatin': [513], 'condensation,': [514], 'fragmentation,': [516, 3441], 'formation': [518], 'apoptotic': [520, 3119, 3190], 'bodies.': [521], 'Phosphatidylserine': [522], 'externalization': [523], 'are': [527, 536, 1950, 3559, 4089], 'biochemical': [528], 'features': [529, 3120], 'Most': [532], 'these': [534, 3284, 4024], 'processes': [535], 'mediated': [537], 'inactivate': [543, 1134], 'proteins': [544, 1135, 2691, 2857, 3821], 'for': [546, 622, 1546, 1589, 1915, 2164, 2241, 2279, 2301, 2311, 2368, 2445, 2526, 2741, 2799, 3491, 3510, 3612, 4049], 'survival': [548], '(for': [549, 599, 773], 'review,': [550, 600, 776], 'see': [551, 601, 777], 'Ref.': [552, 602, 778], '4Cohen': [553], 'G.M.': [554, 1349], 'J.': [556, 606, 682, 705, 756, 836, 873, 949, 974, 1009, 1037, 1075, 1106, 1111, 1160, 1234, 1351, 1377, 1418, 1443, 1506, 1559, 1561, 1620, 1649, 1654, 1699, 1762, 1767, 1784, 1825, 2122, 2177, 2403, 2604, 2710, 2834, 2887, 2889, 2942, 2965, 3030, 3032, 3061, 3137, 3139, 3168, 3352, 3654, 3659, 3688, 3721, 3726, 3755, 3846], '1997;': [557, 876, 1012, 1078, 1315, 1352, 1421], '326:': [558, 1353], '1-16Crossref': [559, 1354], '(4146)': [562, 1357], 'apoptosis,': [568], '"accidental"': [572], 'profound': [577], 'alterations': [580], 'oncosis.': [582], 'Intermediate': [583], 'forms': [584, 1284], 'programmed': [586, 650], 'death,': [588, 594], 'namely': [589, 1213], 'apoptosis-': [590], 'necrosis-like': [592], 'recently': [597, 2910], 'described': [598, 1691, 2826], '5Jaattela': [603], 'M.': [604, 670, 744, 807, 826, 842, 846, 941, 943, 964, 980, 984, 1070, 1309, 2111, 2400, 2930, 3340], 'Tschopp': [605, 681, 755, 2941, 3351], 'Nat.': [607, 683, 757, 2943, 3353], 'Immunol.': [608, 684, 758, 2123, 2944, 3354], '2003;': [609], '4:': [610], '416-423Crossref': [611], '(339)': [614], 'Programmed': [617], 'elimination': [623], 'self-reactive': [625], 'lymphocytes': [626], 'down-regulation': [628], 'response.': [632, 4265], 'Stimulation': [633], 'receptor': [636], '(CD95)': [637], '(CD95L': [640], 'or': [641, 1412, 1943, 2168, 2248, 2251, 2505, 2524, 3231, 3497, 3516, 3555, 4043, 4076, 4349], 'CD178)': [642], 'plays': [643], 'crucial': [645], 'role': [646, 1725], 'inducing': [648], 'lymphocyte': [649], 'death.': [652], 'cross-linking': [654], 'triggers': [655], 'both': [658, 1482, 3820, 4140], 'caspase-dependent': [659, 3816], '-independent': [661], 'pathways': [662, 730, 768], '(6Holler': [663, 737, 2923, 3333], 'N.': [664, 738, 2384, 2924, 3334], 'Zaru': [665, 739, 2925, 3335], 'R.': [666, 740, 844, 982, 2398, 2593, 2926, 3336], 'Micheau': [667, 741, 2927, 3337], 'O.': [668, 742, 2388, 2829, 2928, 3338], 'Thome': [669, 743, 2929, 3339], 'Attinger': [671, 745, 2931, 3341], 'Valitutti': [673, 747, 2933, 3343], 'Bodmer': [675, 749, 2935, 3345], 'J.L.': [676, 750, 2936, 3346], 'Schneider': [677, 751, 2937, 3347], 'P.': [678, 752, 1102, 1301, 1555, 1645, 1758, 2883, 2938, 3026, 3049, 3055, 3133, 3156, 3162, 3348, 3650, 3717], 'Seed': [679, 753, 2939, 3349], '2000;': [685, 708, 759, 2837, 2945, 2968, 3355], '1:': [686, 760, 2946, 3356], '489-495Crossref': [687, 761, 2947, 3357], '(1467)': [690, 764, 2950, 3360], 'Scholar,': [692, 1004, 1068, 1090, 1174, 1248, 1782, 2952, 3047, 3154, 3674, 3741], '7Matsumura': [693, 2953], 'H.': [694, 1098, 1154, 1156, 1180, 1228, 1230, 1254, 1641, 1754, 1817, 1823, 2117, 2704, 2706, 2954, 3646, 3680, 3686, 3713, 3747, 3753], 'Shimizu': [695, 2955], 'Y.': [696, 698, 702, 2115, 2956, 2958, 2962], 'Ohsawa': [697, 2957], 'Kawahara': [699, 2959], 'Uchiyama': [701, 2961], 'Nagata': [703, 2963], '151:': [709, 2969], '1247-1256Crossref': [710, 2970], '(207)': [713, 2973], 'Caspase-independent': [716, 3258], 'requires': [719], 'receptor-interacting': [720, 1499], 'protein': [721, 914, 1500, 2499, 2569, 2654, 2732, 2806, 2815, 3082, 3540, 4061], '(RIP)': [722], 'effector': [725, 910, 1030, 1129, 1298, 1337], 'molecule,': [726], 'activated': [731, 1679, 1693, 3632, 4352], 'RIP': [733], 'remain': [734], 'largely': [735], 'unknown': [736], 'Caspase-dependent': [767, 3256], 'extensively': [771], 'explored': [772], 'recent': [775], '8Thorburn': [779], 'Cell.': [781, 810, 853, 991, 1161, 1185, 1235, 1259, 1314, 2711], 'Signal.': [782], '2004;': [783, 3849], '16:': [784], '139-144Crossref': [785], '(654)': [788], 'Oligomerization': [791], 'leads': [796], 'successive': [798], 'recruitment': [799], 'FADD': [801, 2165, 3072, 4192], '(9Chinnaiyan': [802], 'A.M.': [803, 828, 966], "O'Rourke": [804, 831, 969], 'K.': [805, 832, 970, 2599], 'Tewari': [806], 'Dixit': [808, 851, 871, 989, 1007, 1073, 1416], 'V.M.': [809, 852, 872, 990, 1008, 1074, 1417], '81:': [812], '505-512Abstract': [813], 'Full': [814, 857, 859, 879, 881, 995, 997, 1015, 1017, 1081, 1083, 1117, 1119, 1165, 1167, 1189, 1191, 1239, 1241, 1263, 1265, 1318, 1320, 1424, 1426, 1449, 1451, 1567, 1569, 1660, 1662, 1773, 1775, 2409, 2411, 2715, 2717, 2840, 2842, 2895, 2897, 3038, 3040, 3145, 3147, 3665, 3667, 3732, 3734, 3852, 3854], 'Text': [815, 858, 860, 880, 882, 996, 998, 1016, 1018, 1082, 1084, 1118, 1120, 1166, 1168, 1190, 1192, 1240, 1242, 1264, 1266, 1319, 1321, 1425, 1427, 1450, 1452, 1568, 1570, 1661, 1663, 1774, 1776, 2410, 2412, 2716, 2718, 2841, 2843, 2896, 2898, 3039, 3041, 3146, 3148, 3666, 3668, 3733, 3735, 3853, 3855], 'PDF': [816, 861, 883, 999, 1019, 1085, 1121, 1169, 1193, 1243, 1267, 1322, 1428, 1453, 1571, 1664, 1777, 2413, 2719, 2844, 2899, 3042, 3149, 3669, 3736, 3856], '(2165)': [819], 'Scholar)': [821, 866, 1669, 2614], 'caspase-8': [824, 959, 1141, 1476, 1496, 1535, 1539, 1737, 2140, 2169, 2523, 4016, 4277], '(10Muzio': [825, 963], 'Chinnaiyan': [827, 965], 'Kischkel': [829, 967], 'F.C.': [830, 935, 968, 1092, 1635, 1748, 3640, 3707], 'Shevchenko': [833, 971], 'Ni': [835, 973], 'Scaffidi': [837, 975], 'C.': [838, 870, 976, 1006, 1182, 1256, 1415, 1602, 1608], 'Bretz': [839, 977], 'J.D.': [840, 978, 3839], 'Zhang': [841, 979], 'Gentz': [843, 981], 'Mann': [845, 983], 'Krammer': [847, 944, 985, 1615], 'P.H.': [848, 945, 986, 1616], 'Peter': [849, 946, 987, 1617], 'M.E.': [850, 947, 988, 1618], '1996;': [854, 992, 1061, 1401], '85:': [855, 993], '817-827Abstract': [856, 994], '(2743)': [864, 1002], '-10': [868, 961, 1478, 2144, 2525], '(11Vincenz': [869, 1414], 'Chem.': [875, 1011, 1077, 1113, 1420, 1445, 1656, 1769, 2405, 2836, 3661, 3728, 3848], '272:': [877, 1013, 1079, 1422], '6578-6583Abstract': [878, 1014, 1423], '(240)': [886, 1022, 1431], 'Formation': [889], 'this': [891, 2982], 'complex,': [892], 'termed': [893], 'DISC': [894, 1682, 3635], '1The': [895], 'abbreviations': [896], 'used': [897, 1945, 2042, 2109], 'are:': [898], 'DISC,': [899], 'death-inducing': [900], 'complex;': [902], 'Bid,': [903, 1143, 1215, 3870], 'domain;': [907, 911, 917], 'DED,': [908], 'FADD,': [912], 'Fas-associated': [913], 'PARP,': [918], 'poly-(ADP-ribose)': [919], 'polymerase;': [920], 'PBL,': [921], 'peripheral': [922], 'blood': [923], 'lymphocyte;': [924], 'Z-AEVD-fmk,': [925, 3830], 'benzyloxylcarbonyl-AEVD-fluoromethylketone;': [926], 'Z-VAD-fmk,': [927, 3319, 3812], 'benzyloxycarbonyl-VAD-fluoromethylketone;': [928], 'PE,': [929], 'phycoerythrin.': [930], '(death-inducing': [931], 'complex)': [933], '(12Kischkel': [934], 'Hellbardt': [936], 'Behrmann': [938], 'I.': [939, 1178, 1252, 1305], 'Germer': [940], 'Pawlita': [942], 'EMBO': [948, 1619, 1824, 3687, 3754], '14:': [951], '5579-5588Crossref': [952], '(1792)': [955], 'Scholar),': [957, 1408, 1433, 1807, 3362, 3696], 'allows': [958], '11Vincenz': [1005], 'Both': [1025, 2976], 'directly': [1028], 'activate': [1029], '(13Fernandes-Alnemri': [1032, 1372], 'T.': [1033, 1373, 2119, 2402], 'Armstrong': [1034, 1374], 'R.C.': [1035, 1375], 'Krebs': [1036, 1376], 'Srinivasula': [1038, 1306, 1378], 'S.M.': [1039, 1307, 1379], 'Wang': [1040, 1183, 1257, 1312, 1380], 'L.': [1041, 1381, 2831], 'Bullrich': [1042, 1382], 'F.': [1043, 1383, 1610], 'Fritz': [1044, 1384], 'L.C.': [1045, 1385], 'Trapani': [1046, 1386], 'J.A.': [1047, 1387], 'Tomaselli': [1048, 1388, 1611], 'K.J.': [1049, 1389, 1612], 'Litwack': [1050, 1390], 'G.': [1051, 1391, 2005], 'Alnemri': [1052, 1310, 1392], 'E.S.': [1053, 1311, 1393], 'Proc.': [1054, 1394, 1515, 1708, 1793], 'Natl.': [1055, 1395, 1516, 1709, 1794], 'Acad.': [1056, 1396, 1517, 1710, 1795], 'Sci.': [1057, 1397, 1518, 1711, 1796], 'U.': [1058, 1398, 1519, 1712, 1797], '93:': [1062, 1402], '7464-7469Crossref': [1063, 1403], '(694)': [1066, 1406], '14Muzio': [1069], 'Salvesen': [1071], 'G.S.': [1072], '2952-2956Abstract': [1080], '(313)': [1088], '15Kischkel': [1091], 'Lawrence': [1093, 1636, 1749, 3641, 3708], 'D.A.': [1094, 1637, 1750, 3642, 3709], 'Tinel': [1095, 1638, 1751, 3643, 3710], 'LeBlanc': [1097, 1640, 1753, 3645, 3712], 'Virmani': [1099, 1642, 1755, 3647, 3714], 'Schow': [1101, 1644, 1757, 3649, 3716], 'Gazdar': [1103, 1646, 1759, 3651, 3718], 'Blenis': [1105, 1560, 1648, 1761, 2178, 2888, 3031, 3060, 3138, 3167, 3653, 3720], 'Arnott': [1107, 1650, 1763, 3655, 3722], 'D.': [1108, 1303, 1651, 1764, 2390, 3656, 3723], 'Ashkenazi': [1109, 1631, 1652, 1765, 3657, 3724], '2001;': [1114, 1522, 1657, 1715, 1770, 1800, 3662, 3729], '276:': [1115, 1658, 1771, 3663, 3730], '46639-46646Abstract': [1116, 1659, 1772, 3664, 3731], '(430)': [1124, 1667, 1780, 3672, 3739], 'Once': [1127], 'activated,': [1128], 'specifically': [1131], 'addition,': [1140, 1835, 1911], 'cleaves': [1142, 1295], 'pro-apoptotic': [1145], 'member': [1146], 'lymphoma-2': [1151, 1208], 'superfamily': [1152], '(16Li': [1153, 1227, 2703], 'Zhu': [1155, 1229, 2705], 'Xu': [1157, 1231, 2707], 'C.J.': [1158, 1232, 1557, 2708, 2885, 3028, 3053, 3135, 3160], 'Yuan': [1159, 1233, 1558, 2709, 2886, 3029, 3136], '94:': [1163, 1187, 1237, 1261, 2713], '491-501Abstract': [1164, 1238, 2714], '(3798)': [1172, 1246, 2722], '17Luo': [1175, 1249], 'X.': [1176, 1184, 1250, 1258, 1313, 3841], 'Budihardjo': [1177, 1251, 1304], 'Zou': [1179, 1253], 'Slaughter': [1181, 1255], '481-490Abstract': [1188, 1262], '(3085)': [1196, 1270], 'The': [1199, 1577, 3416, 3764, 3793, 4161], 'terminal': [1200], 'part': [1201], 'containing': [1204, 1343, 2186, 2205, 2545, 2638, 2749], 'homology': [1209, 1474], '(BH)': [1210], '3': [1211], 'domain,': [1212], 'translocates': [1216], 'mitochondria': [1218], 'promotes': [1220], 'into': [1224, 3468], 'cytosol': [1226], 'association': [1274], 'APAF-1': [1276], 'pro-caspase-9,': [1278], 'another': [1279, 1811], 'caspase,': [1281], 'apoptosome': [1286], 'complex': [1287], 'caspase-9': [1293], 'activates': [1297], '(18Li': [1300], 'Nijhawan': [1302], 'Ahmad': [1308], '91:': [1316], '479-489Abstract': [1317], '(6261)': [1325], 'analogy': [1329], 'has': [1333, 1540, 2871], 'two': [1334, 1744, 2906, 4092], 'DEDs': [1335], '(death': [1336], 'domains)': [1338], 'QACQG': [1341], 'sequence': [1342], 'catalytic': [1345, 1471], 'cysteine': [1346], 'residue': [1347], '(4Cohen': [1348], 'To': [1360, 2258, 2285], 'date,': [1361], 'four': [1362], 'different': [1363, 2527, 2907, 4149], 'splice': [1365], 'variants': [1366], 'identified,': [1369], 'caspase-10a': [1370], '(Mch4)': [1371], '-10b': [1409], '(FADD-like': [1410], 'ICE': [1411], 'FLICE-2)': [1413], '-10c': [1434], '-10d': [1436, 1466], '(19Ng': [1437], 'P.W.': [1438], 'Porter': [1439], 'A.G.': [1440], 'Janicke': [1441], 'R.U.': [1442], '274:': [1447, 2407], '10301-10308Abstract': [1448], '(77)': [1456], 'caspase-10c,': [1462], 'caspase-10a,': [1463], '-10b,': [1464], 'large': [1468], 'small': [1470], 'subunits.': [1472], 'Strong': [1473], 'between': [1475], 'might': [1479, 3960, 3975], 'enzymes': [1483], 'share': [1484, 2692], 'similar': [1485, 3101, 4209], 'substrate': [1486, 1924], 'specificity': [1487], 'biological': [1489], 'function.': [1490], 'However,': [1491, 1723, 2905], 'FasL-treated': [1502, 1685, 1740], '(20Wang': [1505, 1698], 'Chun': [1507, 1700, 1785], 'H.J.': [1508, 1701, 1786], 'Wong': [1509, 1702, 1787], 'W.': [1510, 1703, 1788], 'Spencer': [1511, 1704, 1789], 'D.M.': [1512, 1705, 1790], 'Lenardo': [1513, 1706, 1791], 'M.J.': [1514, 1707, 1792], '98:': [1523, 1716, 1801], '13884-13888Crossref': [1524, 1717, 1802], '(312)': [1527, 1720, 1805], 'T': [1531, 2154], 'lymphoma': [1532, 2155], 'contain': [1534], '-10,': [1537], 'induction': [1548], 'stimulation': [1553], '(21Juo': [1554, 2882, 3025, 3132], 'Kuo': [1556, 2884, 3027, 3052, 3134, 3159], 'Curr.': [1562, 2890, 3033, 3140], '8:': [1565, 2893, 3036, 3143], '1001-1008Abstract': [1566, 2894, 3037, 3144], '(472)': [1574, 2902, 3045, 3152], 'mitochondrial': [1578, 1939], 'pathway': [1579], 'involving': [1580], 'reported': [1585, 1670, 2874], 'critical': [1588], 'cells,': [1595, 1868, 3285, 4299, 4304], 'classified': [1596], 'type': [1598], 'II': [1599], '(22Scaffidi': [1601], 'Fulda': [1603], 'Srinivasan': [1605], 'Friesen': [1607], 'Li': [1609], 'Debatin': [1613], 'K.M.': [1614], '17:': [1622], '1675-1687Crossref': [1623], '(2633)': [1626], 'More': [1629], 'recently,': [1630], 'co-workers': [1633], '(15Kischkel': [1634, 1747, 3639, 3706], 'endogenous': [1672, 1873], 'recruited': [1676, 3629], 'at': [1680, 2043, 2244, 2282, 2304, 2314, 2371, 2448, 2467, 2533, 2626, 2792, 2796, 3112, 3244, 3617, 3633, 3885, 3910, 3939, 3950, 3988], 'level': [1683, 3765], 'cells.': [1687, 1898, 3003, 3484, 4034, 4144, 4357], 'Similar': [1688, 2129], 'findings': [1689], 'PBL': [1694], 'upon': [1695], 'ligation': [1697], 'remains': [1731], 'controversial.': [1732], 'Overexpression': [1733], 'complemented': [1736], 'independent': [1745, 3218, 3294, 3400, 3563, 4093], 'studies': [1746, 2977], '20Wang': [1783], '(23Sprick': [1812], 'M.R.': [1813, 3676, 3743], 'Rieser': [1814, 3677, 3744], 'E.': [1815, 3678, 3745], 'Stahl': [1816, 3679, 3746], 'Grosse-Wilde': [1818, 3681, 3748], 'Weigand': [1820, 3683, 3750], 'M.A.': [1821, 3684, 3751], 'Walczak': [1822, 3685, 3752], '2002;': [1826, 3689, 3756], '21:': [1827, 3690, 3757], '4520-4530Crossref': [1828, 3691, 3758], '(297)': [1831, 3694, 3761], 'there': [1836], 'no': [1838], 'direct': [1839, 1923], 'evidence': [1840, 1912], 'literature': [1843], 'able': [1847], 'trigger': [1852], 'release.': [1855, 1887, 3971], 'induce': [1863, 3281], 'which': [1869], 'associated': [1871], 'inhibitor': [1901, 3318, 3833], 'prevented': [1902], 'provided': [1914, 2174], 'first': [1917], 'time': [1918, 3891, 3952, 3990], 'that,': [1929], 'like': [1930], 'Reagents—Final': [1941], 'concentrations': [1942, 3618], 'dilutions': [1944], 'following': [1948], 'reagents': [1949], 'indicated:': [1951], 'Z-VAD(OMe)-fmk': [1952], '(40': [1953], 'μm)': [1954, 1958, 2365, 3864], 'Z-AE(OMe)-VD(OMe)-fmk': [1956], '(10': [1957, 2023, 2066, 3863], 'purchased': [1960, 2016, 2036, 2073, 2148], 'from': [1961, 1992, 2003, 2017, 2027, 2037, 2054, 2074, 2087, 2149, 2503, 2819], 'Bachem': [1962], '(Voisins-Le-Bretonneux,': [1963], 'France)': [1964, 2077], 'RD': [1966], 'systems': [1967], '(Lille,': [1968], 'France),': [1969], 'respectively;': [1970], 'monoclonal': [1971, 2009, 2046], 'anti-FADD': [1972], '(clone': [1973, 1979, 1985, 2011, 2048, 2058, 2157, 2166, 2170, 2669, 3013, 3016, 3020], 'A66-2;': [1974], '0.5': [1975, 1987], 'μg/ml),': [1976, 1982], 'anti-cytochrome': [1977, 4073], '7H8.2C12;': [1980], '1': [1981, 2013, 2579, 2765, 2774], 'anti-caspase-8': [1984], 'B9-2;': [1986], 'μg/ml)': [1988, 2014, 2024, 2051, 2067, 2277, 2359], 'antibodies': [1989, 2034], 'obtained': [1991, 2026, 2053, 2086, 2132], 'BD': [1993], 'Biosciences;': [1994], 'polyclonal': [1995, 2021, 2029], 'anticaspase-8': [1996], '(1/5': [1997], 'dilution)': [1998, 2061], 'kind': [2001], 'gift': [2002], 'Dr.': [2004, 2176], 'Cohen': [2006], '(Leicester,': [2007], 'UK);': [2008], 'anti-caspase-10': [2010, 3704], '4C1;': [2012], 'MBL': [2018], '(Meudon,': [2019], 'France);': [2020], 'anti-caspase-3': [2022], 'Dako;': [2028], 'anti-caspase-7,': [2030], 'anti-PARP,': [2031, 3554, 4075], 'anti-Bid': [2033], 'Signaling': [2039], 'Technology': [2040], '1/1000': [2044], 'dilution;': [2045], 'anti-β-actin': [2047, 3556, 4077], 'AC-15;': [2049], '5': [2050], 'Sigma.': [2055], 'Monoclonal': [2056], 'anti-CD95': [2057], '7C11;': [2059], '1/5': [2060], 'IgM': [2063], 'irrelevant': [2064, 2253], 'antibody': [2065, 2254, 2668, 3705], 'coupled': [2068, 2255], 'phycoerythrin': [2070], '(PE)': [2071], 'Immunotech': [2075], '(Marseille,': [2076], 'Santa': [2079, 2671], 'Cruz,': [2080], 'respectively.': [2081, 3237], 'Human': [2082, 2138], 'recombinant': [2083, 2139, 2522, 2584, 2624], 'Abcys': [2088], '(Paris,': [2089], 'France).': [2090], 'Alternatively,': [2091, 2578, 2673, 3972], 'mouse': [2092, 2134, 2583, 2687], 'produced': [2094], 'supernatant': [2097], 'Neuro-2A': [2099], 'stably': [2101], 'transfected': [2102], 'plasmid': [2105], 'encoding': [2106], '(24Shimizu': [2110], 'Fontana': [2112], 'Takeda': [2114], 'Yagita': [2116], 'Yoshimoto': [2118], 'Matsuzawa': [2120], '162:': [2125], '7350-7357PubMed': [2126], '(6000': [2141], 'units/mg)': [2142, 2146], '(8000': [2145], 'Abcys.': [2150], 'Lines—Parental': [2152], 'A3)': [2158], 'derived': [2160], 'lines': [2162, 3024, 3099, 4164], 'deficient': [2163], 'I2-1)': [2167, 3021], 'I9-2)': [2171], 'kindly': [2173], '(Boston,': [2179], 'MA).': [2180], 'Cells': [2181, 2307, 2434, 4053], 'cultured': [2183, 2201], 'RPMI': [2185, 2203], 'Glutamax': [2187], '10%': [2189, 2206, 2480, 2758], 'heat-inactivated': [2190], 'fetal': [2191, 2207], 'calf': [2192, 2208], 'serum.': [2193], 'limiting': [2195, 4146], 'dilution': [2196, 4147], 'experiments,': [2197, 4148], 'medium': [2204], 'serum': [2209], '96-well': [2211, 2439], 'plates.': [2212], 'From': [2213], 'serial': [2214], 'dilutions,': [2215], 'five': [2216], 'cultures': [2218], 'isolated': [2220], 'named': [2222], 'I9-2a,': [2223], 'I9-2b,': [2224, 4155], 'I9-2c,': [2225, 4156], 'I9-2d,': [2226, 4157], 'I9-2e.': [2228], 'Flow': [2229, 3091, 3201], 'Cytometry': [2230], 'Analyses—CD95': [2231], 'surface': [2233, 3107], 'determined': [2236, 2808, 4084], 'after': [2237], 'incubation': [2238], '30': [2242, 2312, 2742], 'min': [2243, 2281, 2303, 2313, 2370, 2532, 2743], '4': [2245, 2283, 2460, 2797, 3914], '°C': [2246, 2316, 2373, 2469, 2535, 2628, 2798], 'without': [2249, 3471], 'anti-CD95-PE': [2250], 'PE.': [2257], 'allow': [2259, 2286], 'study': [2260, 2287, 3332], 'phosphatidylserine': [2262], 'externalization,': [2263], 'labeled': [2266], 'Annexin': [2268], 'V-fluorescein': [2269], 'isothiocyanate': [2270], '(250': [2271, 2501], 'ng/ml)': [2272, 3183, 3251], 'propidium': [2274, 2322, 2356, 3452], 'iodide': [2275, 2323, 2357, 3453], '(12.5': [2276], '(Immunotech)': [2278], '10': [2280, 2302, 2768, 2778, 2786, 2800], '°C.': [2284, 2306, 2450], 'hypodiploidy,': [2289], 'washed': [2292], 'phosphate-buffered': [2294], 'saline': [2295], 'permeabilized': [2297], 'ethanol': [2299], '(70%)': [2300], '-20': [2305], 'next': [2309, 3270, 3593], 'incubated': [2310, 2509, 2616, 3111, 3227, 3490, 3509, 3611, 3773, 3897, 4039], '37': [2315, 2372, 2449, 2468, 2534, 2627], 'RNase': [2318], '(1': [2319], 'mg/ml)': [2320, 2455], '(0.1': [2324], 'mg/ml).': [2325], 'Percentage': [2326], 'hypodiploid': [2328, 3932, 4081], 'carrying': [2330], 'content': [2332, 2807, 3782, 4373], 'below': [2333], 'G0/G1': [2336], 'quantified': [2338, 2484], 'flow': [2340, 3424, 4086], 'cytometry.': [2341, 4087], 'Analyses': [2342], 'performed': [2344], 'on': [2345, 2563, 2658, 2677, 2744, 2860, 3104], 'FACScan': [2347], '(BD': [2348], 'Biosciences)': [2349], 'cytometer.': [2350], 'Morphological': [2351], 'Analyses—Cells': [2352], 'co-incubated': [2354], '(2': [2358], '(Sigma)': [2360, 2456], 'Syto': [2362], '13': [2363], '(2.5': [2364], '(Molecular': [2366], 'Probes)': [2367], '15': [2369, 3276], 'analyzed': [2375, 2662, 3075, 3594], 'under': [2376], 'Leica': [2378], 'fluorescence-equipped': [2379], 'microscope': [2380], '(25Segui': [2381], 'Andrieu-Abadie': [2383], 'Adam-Klages': [2385], 'Meilhac': [2387], 'Kreder': [2389], 'Garcia': [2391], 'V.': [2392], 'Bruno': [2393], 'A.P.': [2394], 'Jaffrezou': [2395], 'J.P.': [2396], 'Salvayre': [2397], 'Kronke': [2399], 'Levade': [2401], '37251-37258Abstract': [2408], '(60)': [2416], 'At': [2419, 2554, 2647], 'least': [2420], '300': [2421], 'examined.': [2424], 'MTT': [2425, 2432], 'Assay—Viability': [2426], 'evaluated': [2428, 3422, 3927], 'tetrazolium-based': [2431], 'assay.': [2433], 'seeded': [2436], 'flat-bottom': [2438], 'plates': [2440], '(106': [2441], 'cells/ml,': [2442], '100': [2443, 2472, 2651], 'μl/well)': [2444], '16': [2446, 3492, 3511, 3613, 3886, 3956], 'h': [2447, 3493, 3512, 3614, 3887, 3915], '3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium': [2451], 'bromide': [2452], '(MTT)': [2453], '(0.5': [2454], 'added': [2458], 'during': [2459], 'h.': [2461, 3941], 'Formazan': [2462], 'crystals': [2463], 'solubilized': [2465], 'overnight': [2466], 'adding': [2471], 'μl': [2473, 2542, 2635], 'solubilization': [2475], 'buffer': [2476, 2544, 2637, 2748], '(HCl': [2477], '0.01': [2478], 'N,': [2479], 'SDS)': [2481], 'spectrophotometrically': [2483], 'using': [2485, 3701], 'enzyme-linked': [2487], 'immunosorbent': [2488], 'assay': [2489, 3974], 'reader': [2490], '(λ': [2491], '=': [2492], '590': [2493], 'nm).': [2494], 'Cell-free': [2495], 'System': [2496], 'Assay—Mitochondria-free': [2497], 'cytosolic': [2498, 4060], 'extracts': [2500, 2674, 2816], 'μg)': [2502], 'A3': [2504, 3125, 4268], 'presence': [2512, 2619, 3230, 3409, 3496, 3515, 3810, 4042], 'one': [2514, 2621], 'unit': [2515, 2622], '(as': [2516], 'defined': [2517], 'manufacturer)': [2520], 'times': [2528], 'up': [2529], '90': [2531], 'final': [2538, 2631], 'volume': [2539, 2632], '200': [2541], '50': [2546, 2639, 2750, 2771, 3536], 'mm': [2547, 2552, 2640, 2645, 2751, 2756, 2766, 2769, 2772, 2775], 'HEPES,': [2548, 2641, 2752], 'pH': [2549, 2642, 2753], '7.5,': [2550, 2643, 2754], '150': [2551, 2644, 2755], 'NaCl.': [2553, 2646], 'indicated': [2556, 2649, 3094, 3204, 3501, 3901, 4051, 4116], 'times,': [2557, 2650], 'reaction': [2558], 'stopped': [2560], 'freezing': [2562], 'dry': [2564, 2659], 'ice.': [2565], '20': [2566, 2820, 4057], 'μg': [2567, 2580, 3537, 4058], 'subjected': [2571, 3543, 4064], 'SDS-PAGE': [2573, 2679, 3545, 4066], 'Western': [2575, 2664, 2728, 2851, 3077, 3547, 3596, 4068], 'blotting': [2576, 2665, 3078, 3597], 'analysis.': [2577], 'His-tagged': [2582], '(26Desagher': [2586], 'Osen-Sand': [2588], 'Nichols': [2590], 'Eskes': [2592], 'Montessuit': [2594], 'Lauper': [2596], 'Maundrell': [2598], 'Antonsson': [2600], 'Martinou': [2602], 'J.C.': [2603], '144:': [2608], '891-901Crossref': [2609], '(1093)': [2612], '60': [2634, 3621], 'ng': [2652], 'immediately': [2656], 'frozen': [2657], 'ice': [2660, 2745], 'anti-His': [2667], 'sc8036,': [2670], 'Cruz).': [2672], 'separated': [2676, 2859], '15%': [2678, 2861], 'stained': [2681], 'Coomassie': [2683], 'blue.': [2684], 'Of': [2685, 4200], 'note,': [2686, 4201], '63.5%': [2693], 'identity': [2694], 'LQTD': [2697], '↓': [2698], 'G': [2699], 'motif': [2702], 'Protein': [2725], 'Extraction': [2726], 'Blotting': [2729], 'Analyses—For': [2730], 'total': [2731, 3539], 'extraction,': [2733], '5-20': [2734], '×': [2735, 2794, 2821], '106': [2736, 2822], 'lysed': [2740], 'NaCl,': [2757], 'glycerol,': [2759], '1%': [2760], 'Triton': [2761], 'X-100,': [2762], '0.5%': [2763], 'deoxycholate,': [2764], 'NaVO4,': [2767], 'β-glycerophosphate,': [2770], 'NaF,': [2773], 'phenylmethylsulfonyl': [2776], 'fluoride,': [2777], 'μg/ml': [2779, 2782, 2787], 'leupeptin,': [2780], '2': [2781], 'pepstatin': [2783], 'A,': [2784, 3485], 'aprotinin.': [2788], 'Samples': [2789], 'centrifuged': [2791], '10,000': [2793], 'g': [2795], 'min.': [2801], 'Supernatants': [2802], 'collected': [2804], 'Bradford': [2811], 'method': [2812], '(Bio-Rad).': [2813], 'Cytosolic': [2814], 'prepared': [2818], 'previously': [2827, 2872], '(27Cuvillier': [2828], 'Edsall': [2830], 'Spiegel': [2832], '275:': [2838], '15691-15700Abstract': [2839], '(154)': [2847], 'For': [2850], 'blot': [2852], 'analyses,': [2853], 'equal': [2854], 'amount': [2855, 4382], 'SDS-PAGE.': [2862], 'Can': [2864], 'Trigger': [2865], 'Caspase-8-deficient': [2868, 3262, 3584, 4035], 'Cells—Caspase-8': [2870], 'anti-Fas-induced': [2879], 'groups': [2908], 'caspase-8-independent': [2913, 2983, 2998], 'occurs': [2916], 'concentration': [2922, 3116, 3181], 'reached': [2978], 'conclusion': [2980], 'form': [2988], 'rather': [2991], 'than': [2992, 3620, 4287], 're-examined': [2997], 'First,': [3004], 'compared': [3006], 'parental': [3012, 4206], 'A3),': [3014], 'I9-2),': [3017], 'FADD-deficient': [3019, 3238], '28Juo': [3048, 3155], 'Woo': [3050, 3157], 'M.S.': [3051, 3158], 'Signorelli': [3054, 3161], 'Biemann': [3056, 3163], 'H.P.': [3057, 3164], 'Hannun': [3058, 3165], 'Y.A.': [3059, 3166], 'Growth': [3063, 3170], 'Differ.': [3064, 3171], '10:': [3066, 3173], '797-804PubMed': [3067, 3174], 'Caspase-8': [3070], 'confirm': [3080], 'respective': [3081], 'I2-1': [3087], 'clones': [3088], '(Fig.': [3089, 3108, 3199, 3252, 3307, 3381, 3414, 3426, 3431, 3455, 3598, 3623, 3822, 3873, 3888, 3920, 4170, 4193, 4198, 4290, 4342, 4374, 4393], '1A).': [3090], 'cytometry': [3092, 3202, 3425], 'analysis': [3093, 3203], 'various': [3097, 4162, 4363], 'exhibited': [3100, 4173], '1B).': [3109], 'When': [3110, 3177], '(15': [3117], 'ng/ml),': [3118], 'seen': [3122], 'only': [3123, 3949, 4118, 4273], 'previous': [3130, 3331], 'reports': [3131], 'higher': [3179, 3619], '(500': [3182], 'used,': [3185], 'displayed': [3188, 3298, 4165, 4262], 'phenotype': [3191], 'pronounced': [3193], 'condensation': [3195, 3445], '1C).': [3200, 3253], '54.4': [3206], '±': [3207, 3211, 3214, 3287, 3290, 3393, 3396], '4.4%': [3208], '11.5': [3210], '3.6%': [3212], '(mean': [3213, 3289, 3395], 'S.D.': [3215, 3291, 3397], 'three': [3217, 3293, 3399, 3562], 'experiments)': [3219, 3295, 3401], 'scored': [3224], 'Annexin-V-positive': [3225, 3406], 'when': [3226], 'absence': [3232, 3498, 3517, 4014, 4044], '500': [3234, 3250, 3304, 3519, 3790, 3899, 4046], 'ng/ml': [3235, 3277, 3305, 3520, 3622, 3791, 3900, 4047], 'FasL,': [3236, 3775], 'resisted': [3241, 4249], 'all': [3245, 4222], 'doses': [3246], 'tested': [3247], '(up': [3248], 'Induces': [3255], 'Death': [3260], 'Cells—DNA': [3264], 'assessed': [3271], 'measuring': [3273], 'hypodiploidy.': [3274], 'Although': [3275], 'did': [3279, 3966], 'hypodiploidy': [3282, 3884, 4378], '14.4': [3286], '1.6%': [3288], 'them': [3297], '2A).': [3308], 'This': [3309, 3958], 'broad-spectrum': [3316], 'involvement': [3321], 'accordance': [3328], 'fully': [3367], 'impaired': [3368, 4294, 4388], 'Z-VAD-fmk': [3370, 3411, 3438, 3458, 3525, 4292, 4390], 'even': [3374, 4011], 'though': [3375], '3B': [3382], 'shown).': [3386, 4219, 4317], 'As': [3387, 3922], 'matter': [3389], 'fact,': [3391], '45.9': [3392], '3.4%': [3394], 'still': [3405], '2B).': [3415], 'size': [3418], 'reduced': [3420], '2C)': [3427], 'microscopic': [3429], 'examination': [3430], '2D).': [3432, 3456], 'It': [3433], 'interest': [3436], 'abrogated': [3439], 'alterations,': [3448], 'uptake': [3454], 'Thus,': [3457], 'weakly': [3459, 4351], 'affected': [3460], 'cytotoxicity,': [3462], 'latter': [3465], 'shifted': [3467], 'fragmentation.Fig.': [3473], '3FasL': [3474], 'induces': [3475, 4027], 'processing': [3480, 3818, 3867], 'concentration.': [3503], 'B,': [3504, 3530], '40': [3523], 'μm': [3524], 'indicated.': [3527], 'then': [3533], 'harvested,': [3534, 4055], 'extract': [3541, 4062], 'blotted': [3548, 4069], 'anti-caspase-10,': [3550, 4071], '-7,': [3551, 3603, 4072, 4191], 'anti-Bid,': [3553], 'antibodies.': [3557, 4078], 'Data': [3558, 4088], 'representative': [3560, 4090], 'experiments.View': [3564, 4094], 'Large': [3565, 4095], 'Image': [3566, 4096], 'Figure': [3567, 4097], 'ViewerDownload': [3568, 4098], 'Hi-res': [3569, 4099], 'image': [3570, 4100], 'Download': [3571, 4101], '(PPT)': [3572, 4102], 'Promotes': [3574], 'Cleavage,': [3576], 'Cytochrome': [3577, 3942], 'Release,': [3579], 'Caspase': [3581, 3587], 'Activation': [3582], 'Cells—': [3586], '3).': [3599], 'Cleavage': [3600], 'caspase-3,': [3602], 'PARP': [3605, 3872, 3907, 4324], '3A).': [3624], 'Because': [3625], '23Sprick': [3675, 3742], 'examined': [3698, 3826], 'specific': [3703], 'pro-caspase-10': [3767], 'decreased': [3769, 3784], 'dosedependent': [3778], 'manner.': [3779], 'Interestingly,': [3780, 4220], 'also': [3783, 3946, 4276], 'disappearance': [3794], 'suggesting': [3814, 4305], 'proteolytic': [3817], '3B).': [3823], 'Next,': [3824], 'effect': [3828], '(29Park': [3834], 'S.J.': [3835], 'Wu': [3836], 'C.H.': [3837], 'Gordon': [3838], 'Zhong': [3840], 'Emami': [3842], 'Safa': [3844], 'A.R.': [3845], '279:': [3850], '51057-51067Abstract': [3851], '(186)': [3859], 'Z-AEVD-fmk': [3862, 4392], '4A)': [3874], 'caspase-3': [3878, 4189, 4319], '(data': [3880, 4217, 4231, 4315, 4320], 'shown)': [3882, 4322], '4B).': [3889], 'course': [3892], 'experiment': [3893], 'cleaved': [3909, 4369], 'early': [3912, 3963, 3989], 'treatment': [3917], '5).': [3921], 'consequence,': [3924], 'quantification': [3930], 'increased': [3934], 'reach': [3936], 'maximum': [3938], '8': [3940], 'efflux': [3944], 'late': [3951], 'points': [3953], '(8': [3954], 'h).': [3957], 'phenomenon': [3959], 'indicate': [3961, 4401], 'require': [3968], 'sensitive': [3978, 4125, 4141, 4256, 4284], 'enough': [3979], 'detect': [3981], 'amounts': [3983], 'released': [3987], 'points.': [3991], 'Together,': [3992], 'support': [3996], 'notion': [3998], 'promote': [4002], 'likely': [4021], 'events.Fig.': [4025], '5FasL': [4026], 'times.': [4052], 'c,': [4074], 'Percentages': [4079], 'Sensitivity': [4103], 'Correlates': [4106], 'Caspase-10': [4108, 4358], 'Concentration': [4109], 'Cells—All': [4112], 'above-mentioned': [4114], 'experiments': [4115], 'about': [4119], 'half': [4120], 'We': [4128], 'hypothesized': [4129], 'heterogeneous': [4134], 'contained': [4136], 'mixture': [4138], 'non-sensitive': [4143], '(I9-2a,': [4154], 'I9-2e)': [4158], 'isolated.': [4160], '6A)': [4171], '(I9-2a': [4175], 'I9-2e),': [4177], 'intermediate': [4178, 4264], '(I9-2b': [4179], 'I9-2c),': [4181], '(I9-2d)': [4184], '6B),': [4194], 'CD95': [4196], '6C).': [4199], 'I9-2b': [4213, 4258, 4335], 'I9-2c': [4215, 4260, 4337], 'although': [4221, 4243], 'died': [4225], 'similarly': [4226, 4278], 'staurosporine': [4230], 'shown),': [4233], 'their': [4234], 'content.': [4241], 'Indeed,': [4242], 'I9-2a': [4244, 4354], 'I9-2e': [4246, 4303, 4356], 'toxicity,': [4251], 'I9-2d': [4252, 4280, 4288, 4298, 4328], 'highly': [4255], 'By': [4266], 'comparison,': [4267], 'expressed': [4271], 'more': [4283], '6A).': [4291], 'efficiently': [4293], 'toxicity': [4296], 'stronger': [4307], 'caspase-10-expressing': [4313], 'Accordingly,': [4318], 'occurred': [4326], 'and,': [4329], 'lesser': [4332], 'extent,': [4333], '7A).': [4343, 4375], 'contrast,': [4345], 'processed': [4360], 'lines,': [4365], 'whereas': [4366], 'proportionally': [4370], 'Similarly,': [4376], '7,': [4394], 'C).': [4397]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2068627962', 'counts_by_year': [{'year': 2024, 'cited_by_count': 2}, {'year': 2023, 'cited_by_count': 1}, {'year': 2022, 'cited_by_count': 6}, {'year': 2021, 'cited_by_count': 5}, {'year': 2020, 'cited_by_count': 4}, {'year': 2019, 'cited_by_count': 2}, {'year': 2018, 'cited_by_count': 3}, {'year': 2017, 'cited_by_count': 4}, {'year': 2016, 'cited_by_count': 2}, {'year': 2015, 'cited_by_count': 5}, {'year': 2014, 'cited_by_count': 6}, {'year': 2013, 'cited_by_count': 3}, {'year': 2012, 'cited_by_count': 5}], 'updated_date': '2024-12-25T07:10:28.142874', 'created_date': '2016-06-24'}
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