Publication Information

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2192, 2353, 2561, 2603, 2606, 2662, 2705, 2830, 2912, 2925, 2928, 2952, 3191, 3214, 3237, 3250, 3256, 3286, 3438, 3571, 3582, 3609, 3616, 3635, 3677, 3691, 3694, 3751, 3794, 3822, 3858, 3916, 3920, 4032, 4039, 4049, 4062, 4094, 4108, 4128, 4206, 4300, 4340, 4352, 4667, 4692, 4755], 'article': [144], 'with': [145, 407, 1332, 1394, 1849, 1862, 1916, 2026, 2038, 2291, 3024, 3077, 3185, 3598, 3753, 3775, 3809, 3881, 4191], 'your': [146], 'friends': [147], 'colleagues.': [149], 'Learn': [150], 'more.Copy': [151], 'URL': [152], 'In': [153, 555, 582, 844, 1047, 1237, 2730, 2896, 4416, 4852], '20th': [155, 433, 790], 'century,': [156, 238, 837], 'predicting': [157, 2710, 3887], 'ecological': [158, 514, 2408, 3394, 3416, 3805, 4118, 4688], 'risk': [159, 239, 481, 515, 1094, 1127, 1219, 1367, 1411, 1565, 2248, 2409, 2504, 2585, 2898, 3014, 3330, 3395, 3580, 3818, 4046, 4072, 4119, 4242, 4263, 4328, 4689, 4759, 4932, 4958, 5017], 'from': [160, 188, 196, 243, 255, 266, 431, 508, 550, 592, 608, 766, 1285, 1800, 2141, 2817, 3022, 3188, 3785, 3959, 4038, 4378], 'use': [162, 1168, 1481, 1645, 1711, 1798, 1901, 1982, 2239, 2349, 3982], 'certain': [164, 687, 755, 988, 3115], 'chemicals': [165, 375, 881, 889, 897, 992, 1039, 1562, 1765, 3559, 4753], 'relied': [166], 'on': [167, 205, 357, 544, 793, 1063, 1132, 1246, 1289, 1297, 1362, 1541, 1705, 1720, 1888, 2276, 2352, 2390, 2462, 2591, 3252, 3402, 4054, 4406, 4431, 4557, 4635, 4648, 4754, 4839], 'testing': [168, 531, 850, 958, 972, 1010, 1056, 1158, 1265, 1284, 1292, 1305, 1380, 1810, 3308, 4044, 4137, 4659, 4706, 4732, 4817, 4878], 'programs': [169, 532, 1079], 'that': [170, 221, 489, 594, 717, 733, 757, 783, 1080, 1145, 1155, 1163, 1277, 1307, 1374, 1418, 1434, 1489, 1621, 1708, 1750, 1796, 1820, 1847, 1897, 2007, 2018, 2049, 2103, 2120, 2207, 2325, 2465, 2548, 2623, 2634, 2664, 2676, 2698, 2704, 2810, 2854, 2866, 2874, 2887, 2941, 2965, 2999, 3031, 3083, 3418, 3433, 3516, 3573, 3674, 3782, 3918, 3946, 3952, 3996, 4024, 4096, 4126, 4319, 4325, 4411, 4419, 4425, 4615], 'directly': [171, 545, 3466], 'measured': [172, 1592, 1603, 3316, 3467], 'adverse': [173, 548, 871, 1600, 1754, 1802, 1864, 2197, 2430, 2532, 2641, 2878, 2893, 3290, 3444, 3640, 3732, 3848, 3908, 3924], 'outcomes': [174, 549, 1601, 2198, 2894, 3469, 3931], '(death,': [175], 'disease,': [176, 3937], 'reproductive': [177, 3478, 3939], 'failure,': [178, 3479], 'or': [179, 195, 209, 537, 1028, 1140, 1503, 1596, 1607, 1619, 1627, 1632, 1649, 1873, 1953, 2085, 2243, 2306, 2468, 2516, 2524, 2696, 3035, 3087, 3124, 3140, 3335, 3352, 3413, 3452, 3480, 3508, 3511, 3526, 3548, 3554, 3578, 3727, 3800, 3806, 3814, 3830, 3863, 3938, 3940, 3957, 4102, 4116, 4250, 4621], 'developmental': [180, 3481, 3941], 'dysfunction)': [181], 'using': [182, 278, 1316, 2139, 3537], 'vivo': [184, 552, 848, 971, 1349, 3474, 3930], 'toxicity': [185, 528, 553, 849, 867, 1030, 1115, 1138, 1264, 1283, 1304, 1314, 1427, 1771, 1890, 1969, 2034, 2193, 2456, 2693, 2753, 3026, 3348, 3816, 4105, 4136, 4956], 'tests.': [186, 554, 2046], 'Extrapolation': [187], 'these': [189, 358, 956, 1552, 1801, 2688], 'tests—from': [190], 'one': [191, 588, 857, 1294], 'species': [192, 589, 3055, 3100, 3177], 'another': [194], 'controlled': [197, 609], 'laboratory': [198, 600, 610], 'tests': [199, 732, 1139, 1648, 1833, 2695], 'uncontrolled': [201, 614], 'real-world': [202], 'environments—was': [203], 'based': [204, 1062, 1131, 1288, 2436, 2441, 2461, 2590, 2850, 4088], 'largely': [206], 'conservative': [207, 627], 'assumptions': [208, 628, 1403], 'arbitrary': [210, 630, 1405, 4175], 'uncertainty': [211, 631, 1396, 1406, 4169], 'factors.': [212, 632], 'The': [213, 320, 391, 425, 524, 750, 768, 1096, 1370, 1415, 2177, 2791, 2820, 3064, 3159, 4483, 4630], 'result?': [214], 'Costly,': [215], 'time-consuming,': [216], 'unfocused,': [217], 'contentious': [219], 'assessments': [220, 1985, 2220, 2586, 2899], 'often': [222, 1060, 1084], 'failed': [223], 'inspire': [225], 'public': [226, 415, 894], 'confidence': [227, 416, 4321], 'regulatory': [230, 418, 535, 573, 1078, 1122, 4043, 4693], 'policy': [232], 'decisions.': [233], 'But': [234], 'assessment': [240, 516, 883, 1012, 1128, 1220, 1368, 1412, 1812, 2410, 2496, 3015, 4073, 4690, 4820], 'can': [241, 330, 361, 669, 1490, 1726, 1777, 1898, 1956, 1971, 2008, 2050, 2288, 2987, 3001, 3057, 3274, 3517, 4092], 'benefit': [242], 'increased': [245, 257, 909], 'understanding': [246, 1924, 3885, 4056], 'how': [248, 1721, 1764, 1774, 2204, 2232, 2286, 3699, 4432], 'biological': [249, 263, 284, 385, 1506, 1858, 2716, 2728, 2778, 2883, 3546, 3651, 3772, 3874, 3879, 3985, 4636], 'systems': [250, 3547, 3892, 4213, 4633], 'respond': [251], 'subtle': [253], 'perturbation,': [254], 'capacity': [258], 'measure': [260, 1500, 3604, 3623], 'monitor': [262], 'states,': [264], 'improved': [268, 338, 1149], 'ability': [269, 339, 370, 1498, 1543, 2748], 'analyze,': [271], 'integrate,': [272, 341], 'manage,': [273], 'model': [275, 3258], 'complex': [276, 345, 613, 3491], 'data': [277, 316, 328, 346, 561, 580, 960, 1031, 1065, 1090, 1154, 1465, 1484, 1533, 1553, 1629, 1634, 1651, 1716, 1906, 1980, 2140, 2171, 2770, 3028, 3199, 3282, 3342, 3492, 3993, 4005, 4029, 4106, 4276, 4337, 4356, 4359], 'modern': [279], 'computers.': [280], 'Advances': [281, 4244], '21st-century': [283, 359, 557, 667, 1580, 1722, 2214, 2426, 2577, 3171, 4162], 'methods,': [285, 1057], 'including': [286], 'transcriptomics,': [287, 3587], 'proteomics,': [288, 3588], 'metabolomics,': [289], 'vitro,': [291, 3459, 4101], 'high-throughput': [293, 1327, 1377, 1520], 'technologies,': [294], 'enable': [295, 2297], 'us': [296, 1523, 1623, 2037], 'simultaneously': [298, 1508, 3603], 'examine': [299], 'effects': [300, 2990, 3528, 3641, 3849, 3910], 'cell': [303, 1595], 'tissue': [305, 1597], 'level,': [306, 3320], 'while': [307, 3179, 4177, 4427], 'improving': [308], 'efficiency,': [310], 'economy,': [311], 'reliability': [313], 'collection': [318], 'methods.': [319, 1813], 'dramatic': [321], 'increase': [322, 1455], 'amount': [325, 4375], 'toxicological': [327, 1218, 3807, 3987], 'we': [329, 570, 634, 647, 824, 1172, 1181, 1639, 1655, 1756, 1797, 1821, 1991, 2001, 3000, 3040, 3130, 4091, 4214, 4283, 4304, 4412], 'collect': [331], 'analyze': [333], 'is': [334, 393, 806, 973, 1099, 1914, 2367, 2471, 2534, 2771, 3378, 3574, 3702, 3824, 3837, 3975, 3997, 4122, 4285, 4293, 4344, 4364, 4389], 'complemented': [335], 'synthesize,': [342], 'manage': [344, 1549], 'sets': [347, 4277], 'through': [348, 2062, 2341, 3046, 3450, 3716, 4170, 4186], 'power': [350], 'computational': [352, 1320, 2137, 2294, 3353], 'biology': [353, 1321, 2295, 2920], 'bioinformatics.': [355], 'Capitalizing': [356], 'tools': [360, 1618, 2681, 4020, 4160], 'accelerate': [362], 'rate': [364], 'discovery': [366, 2300, 2335, 2380], 'enhance': [368], 'classify': [372], 'characterize': [374], 'according': [376], 'ways': [379], 'which': [381, 689, 815, 860, 2909, 3253, 3735], 'they': [382, 1703, 2202, 2230, 2458, 3321, 3390], 'disrupt': [383], 'normal': [384, 3786], 'activity': [386, 3808], '(their': [387], 'modes': [388], 'action).': [390], 'result': [392, 3906], 'potentially': [394, 649, 1183], 'cost-effective,': [396], 'timely,': [397], 'informative': [399, 2493], 'assessments,': [400], 'as': [401, 403, 464, 466, 470, 810, 877, 892, 904, 941, 1017, 1224, 1662, 2149, 2221, 2223, 2781, 2783, 2829, 2951, 3109, 3148, 3213, 3263, 3345, 3915, 3935, 4107, 4233, 4510, 4512, 4564, 4566], 'well': [402, 465, 2222, 2782, 4511, 4565], 'regulations': [404], 'policies': [406], 'greater': [408, 414, 1472], 'transparency': [409], 'validity,': [411], 'thereby': [412, 660, 1194], 'inspiring': [413], 'approaches': [419, 818, 1162, 1209, 1547, 2116, 2377, 3053, 3098, 4634], 'human': [421, 1262, 1337, 1699, 2157, 5009], 'environmental': [423, 480, 2467, 2618, 2738, 3118, 4184, 4822, 5016], 'protection.': [424], 'prospect': [426], 'supporting': [428, 1359], "ecotoxicology's": [429, 1576], 'transition': [430, 507, 1577, 4063], 'century': [437, 4388], 'drew': [438], '44': [439], 'expert': [440], 'scientists': [441], 'SETAC': [444, 1664, 2110, 4528], 'Pellston': [445, 4515], 'workshop': [446, 1665, 4421, 4516, 4521, 4542], 'Forest': [448], 'Grove,': [449], 'Oregon,': [450], 'USA,': [451], 'April': [453], '2009.': [454, 4751, 4768, 4876], 'They': [455, 2284], 'represented': [456], 'academia,': [457], 'government,': [458], 'business': [460], 'seven': [462], 'countries': [463], 'diverse': [467, 831], 'disciplines': [468], 'such': [469, 579, 940, 1016, 3147, 3344, 3934, 4013, 4127], 'biochemistry,': [471], 'ecology,': [472], 'molecular': [473, 1851, 1994, 2189, 3439], 'biology,': [474], 'toxicology,': [475], 'bioinformatics,': [476], 'health': [478, 1700, 2158, 3909], 'assessment.': [482, 1095, 2505, 4120, 4243, 4760, 4933], 'Their': [483], 'work': [484, 4440], 'resulted': [485], 'five': [487], 'are': [490, 643, 825, 1061, 1202, 1640, 2326, 2381, 2460, 2492, 2570, 2734, 2848, 2937, 3131, 3283, 3315, 3326, 3355, 3742, 3903, 4201, 4266, 4278, 4335, 4360, 4791], 'included': [491], 'issue': [494], 'Chemistry,': [499], 'each': [500, 870, 1926, 2907], 'addressing': [501, 779, 1363], 'critical': [503, 2005, 2040, 3379], 'aspect': [504], 'traditional': [510, 547, 769, 1409, 2342, 2420, 3302, 4156], '20th-century': [511, 1410, 1889], 'paradigm': [512, 771, 840, 1257, 1438, 1581, 1738, 2395, 3309], '(ERA)': [517], 'an': [519, 775, 1535, 1863, 1948, 1998, 2054, 2466, 2476, 2525, 2531, 2540, 2573, 2599, 2640, 2877, 3136, 3289, 3393, 3443, 3501, 3514, 3731, 3923, 4179, 4349, 4558], 'evolving,': [520], 'groundbreaking': [521], 'new': [522, 1211, 1303, 1437, 1546, 2277, 2371, 3948, 4402, 4736], 'approach.': [523, 2421], 'History': [525], 'Most': [526], 'current': [527, 2142, 3182, 3307, 4135], 'ecotoxicity': [530], 'performed': [533], 'agencies': [536], 'regulated': [539], 'parties': [540], 'continue': [541, 4257, 4310, 4413], 'focus': [543, 1157, 2869], 'measuring': [546], 'contrast,': [556], 'mechanistic': [558, 1153, 2233], 'alternative': [560, 1650, 1713, 1903, 1977, 3339, 4323], 'may': [562, 1129, 2104, 2707, 2888, 4006, 4225], 'be': [563, 624, 820, 1118, 1130, 1148, 1267, 1422, 1461, 1475, 1491, 2010, 2051, 2105, 2210, 2289, 2386, 2589, 2647, 3037, 3058, 3357, 3365, 3518, 3913, 4131, 4148, 4227], 'considered': [564, 2231, 3167], 'some': [566, 4251], 'ERA': [567, 1718, 1908, 2450, 2675], 'scenarios,': [568], 'but': [569, 1124, 1876, 2497, 3697, 3737, 4399], 'lack': [571], 'formal': [572], 'structures': [574], 'generating': [576, 1464], 'applying': [578], 'routinely.': [581], 'addition,': [583, 2731, 2897], 'extrapolation': [585, 1617, 1827, 2546, 2558, 2680, 3056, 3196, 3971, 4089, 4144], 'data—from': [587], 'another,': [591], 'concentrations': [593, 604, 2974], 'cause': [595, 2179, 3569, 3639], 'significant': [596, 1007, 1256, 1310], 'responses': [597, 1591, 2048, 2102, 2245, 2329, 3544], 'realistic': [602, 4429], 'exposure': [603, 1960, 2595, 2622, 2632, 2789, 2976, 3471, 3523], 'environment,': [607, 3564], 'conditions': [611, 3553], 'environments,': [615], 'name': [617], 'few—has': [619], 'been': [620, 953, 994, 1004, 2644, 3034, 3107, 4546, 4591, 4597], 'continues': [622], 'characterized': [625], 'If': [633, 1171, 1638, 3338], 'could': [635, 648, 734, 1147, 1156, 1173, 1182, 2209, 2235, 2690], 'effectively': [636, 1165, 1174, 1557, 2765, 3979], 'predict': [637, 1175, 2019, 3275, 3543, 3815, 4327, 4954, 4982], 'what': [638, 2655, 3688], 'most': [640, 966, 1136, 1177, 2542], 'sensitive': [641, 1137, 1179], 'endpoints': [642, 1507, 1714, 1904, 1978, 2569, 3304, 3340, 4324], 'likely': [644, 1178, 2701], 'be,': [646], 'eliminate': [650, 1184], 'need': [652, 1186, 1279, 1657, 2565, 2587, 2824, 2900, 4845], 'conduct': [654, 1188, 1511], 'entire': [656, 1190, 1636, 1682, 3606, 3625], 'battery': [657, 1113, 1191], 'tests,': [659, 1193, 1330, 2084, 3475], 'saving': [661, 1195], 'time,': [662, 676, 804, 1196], 'resources,': [663, 1197, 1448], 'animals.': [665, 983, 1199], 'What': [666], 'do': [670, 4299], 'Researchers': [671], 'have,': [672], 'first': [675, 713, 2627], 'identified': [677], 'mechanisms': [679, 1769, 2479, 2780, 2836, 2858], 'action': [681, 753, 4712, 4953], 'two': [683, 2112, 2375], 'toxins': [684, 737, 756], 'released': [685, 3561, 3838], 'microalgae,': [688], 'contaminate': [690], 'fish': [691, 3212], 'shellfish': [693, 739], 'then': [695, 2009], 'become': [696, 719, 1381], 'toxic': [697, 1938, 3678], 'humans.': [699], 'These': [700, 3231], 'findings': [701], 'obtained': [702], 'vitro': [704, 1299, 1329, 1379, 1516, 2045, 2083, 2216, 2242, 3347, 3761], 'explain': [705], 'neurotoxicity': [707], 'phycotoxins,': [710], 'constitute': [711, 2911], 'step': [714, 1929, 3377], 'toward': [715, 3922, 4048, 4245, 4314], 'antidotes': [716], 'might': [718], 'sanitary': [721], 'economic': [723], 'necessity,': [724], 'raise': [726], 'hopes': [727, 4196], 'new,': [729, 3096], 'reliable,': [730], 'inexpensive': [731], 'detect': [735], 'offered': [740], 'consumers.': [742], '—CNRS': [743], '(Délégation': [744], 'Paris': [745], 'Michel-Ange)': [746], '(March': [747], '17,': [748], '2010).': [749], 'mode': [751, 4710, 4951], 'accumulate': [758], 'seafood.': [760], 'ScienceDaily.': [761], 'Retrieved': [762], 'August': [763], '5,': [764], 'http://www.sciencedaily.com/releases/2010/03/100311092118.htm': [767], 'toxicity-testing': [770, 839], 'has': [772, 884, 890, 901, 3017, 3620, 4064, 4590, 4596], 'certainly': [773], 'played': [774], 'important': [776, 2327, 2574, 3042], 'role': [777, 2575], 'many': [780, 809, 845, 1107, 1400, 1494, 2732], 'contaminant-related': [781], 'issues': [782, 833], 'plagued': [784], 'latter': [786], 'half': [787], 'century.': [791, 2414, 4332], 'Based': [792], 'best': [795, 4238], 'available': [796, 1169, 1483, 2165, 3025, 3281, 3991, 4380], 'practical': [798], 'science': [799, 1723, 3487, 4224, 4368, 4403], 'technology': [801, 1725, 4297, 4370], 'its': [803, 2154, 2161], 'it': [805, 1356, 2923, 3499, 4292, 4397, 4435], 'viewed': [807, 3914], '"gold': [812], 'standard"': [813], 'all': [816, 1347, 2079, 4221, 4513], 'other': [817, 1108, 2309, 2553, 4103], 'should': [819, 1266, 2384, 4021], 'measured.': [821], 'Nevertheless,': [822], 'if': [823, 1990, 2566], 'address': [827, 1659, 1727, 3005], 'nuanced': [829], 'contaminant': [832], 'must': [841, 1117, 1586, 1612, 1762, 3364], 'evolve': [842], '2-6.': [843], 'respects,': [846], 'concept': [853, 2845], '"one': [855], 'problem,': [856], 'test"': [858], '7,': [859], 'purports': [861], 'design': [863, 2213], 'single': [865, 2929], 'definitive': [866], 'test': [868, 3027], 'outcome,': [872, 2879], 'proved': [874], 'unwieldy,': [875], 'particularly': [876, 4530], 'inventory': [879, 887], 'requiring': [882], 'grown.': [885], 'That': [886, 1200], 'grown': [891], 'international': [893], 'concern': [895, 1788], 'about': [896], 'environment': [900, 3841], 'expanded': [902, 963], 'subsequent': [905], 'legislative': [906, 1014], 'requirements': [907, 1015], 'response:': [911], 'REACH': [912], 'legislation': [913], 'Europe,': [915], 'U.S.': [917, 943, 1019, 1240, 4452, 4475, 4802], 'Food': [918], 'Quality': [919, 4465], 'Protection': [920, 933, 945, 4477], 'Act': [921, 926, 934], 'Safe': [923], 'Drinking': [924], 'Water': [925], '1996,': [928], 'Canadian': [931], '1999.': [936], 'Also,': [937], 'voluntary': [938], 'programs,': [939], "Agency's": [946], 'High': [947], 'Production': [948], 'Volume': [949], 'Challenge': [950], 'Program,': [951], 'developed.': [954], 'Under': [955], 'pressures,': [957], 'needs': [961, 4686], 'dramatically': [964], 'industrial': [967], 'chemicals.': [968, 1495, 4717], 'However,': [969, 1440, 2709], 'time-consuming': [974], 'costly,': [976], 'terms': [978, 4068], 'both': [980, 1152, 1660, 2057, 2066, 2385, 4070], 'money': [981], 'As': [984, 2489, 2579, 3039, 3190, 4190, 4216], 'result,': [986], 'only': [987, 1085, 1133, 3687], 'high-risk': [989], 'classes': [990, 3092, 3144], 'subjected': [995, 1005, 4592], 'intensive': [997], 'testing.': [998], 'For': [999, 1988, 2940], 'example,': [1000, 1989], 'pesticides': [1001], 'long': [1002, 3018], 'amounts': [1008], 'under': [1013, 1077, 3850, 4738], 'Federal': [1020], 'Insecticide,': [1021], 'Fungicide': [1022], 'Rodenticide': [1024], 'Act,': [1025], 'whereas': [1026, 1471], 'little': [1027], 'no': [1029, 1225, 4336], 'remain': [1032], 'large': [1035, 1559], 'percentage': [1036], 'currently': [1040], 'commerce': [1042], '2,': [1043, 1413, 1986, 2487, 2583, 4249], '3,': [1044], '8,': [1045, 1074], '9.': [1046], 'absence': [1049], 'efficient': [1052, 1536, 1809], 'cost-effective': [1054, 4188], 'routine': [1055], 'risk–benefit': [1058], 'decisions': [1059, 4185, 4265], 'sparse': [1064], 'predictive': [1067, 1432, 2043, 2058, 2122, 2238, 2752, 3007, 3051, 4117, 4163], 'models': [1068, 1433, 1620, 1823, 2138, 2234, 2559, 2754, 2828, 2853, 2865, 2881, 2950, 2967, 2986, 3003, 3273, 3354, 3539, 3974, 4145], 'questionable': [1070], 'accuracy': [1071], 'applicability': [1073], '10.': [1075], 'Even': [1076], 'require': [1081, 1819, 2544], 'substantial': [1082, 1419, 4065], 'testing,': [1083, 1350], 'subset': [1087], 'drive': [1091, 2481], 'final': [1093, 1126], 'classic': [1097], 'example': [1098], 'pesticide': [1100], 'registration': [1101], 'United': [1104], 'States': [1105], 'countries,': [1109], 'where': [1110], 'defined': [1112, 2003, 3851], 'studies': [1116], 'submitted': [1119], 'authority,': [1123], 'few': [1135, 1469, 2101], 'endpoint': [1141], 'responses.': [1142], 'This': [1143, 2316, 3375, 4121, 4439, 4588], 'suggests': [1144, 2582], 'efficiency': [1146], 'incorporating': [1151, 2922], '3-5': [1159], 'bioinformatic': [1161], 'integrate': [1166, 3489], 'data.': [1170, 4381], 'endpoints,': [1180], 'calls': [1201, 1443], 'increasingly': [1203, 3132, 4097], 'being': [1204, 3576, 4267], 'heard': [1205], 'apply': [1207, 1625, 4295], 'innovative': [1208], 'paradigms': [1212, 1891], 'long-standing': [1215], 'challenges': [1216, 1574, 1707, 1735, 1793, 1817, 3008, 4410, 4737], 'regulation': [1222], 'comes': [1223], 'surprise': [1226], '2.': [1227, 1272, 1339, 1439, 2955, 3911], 'Impetus': [1228], 'Change': [1230], 'Paradigm': [1231, 1571], 'Shift': [1232, 1572], 'Human': [1234], 'Health': [1235, 4605], 'Toxicity': [1236, 1247, 3894, 4448, 4649, 4658, 4816, 4860, 4877], '2007,': [1238], 'National': [1241, 4604, 4669, 4812, 4826], 'Research': [1242, 4458, 4471, 4609, 4813], 'Council': [1243, 4472], '(NRC)': [1244], 'Committee': [1245, 4647], 'Testing': [1248, 4650], 'Assessment': [1250, 4652], 'Agents': [1253, 4655], 'proposed': [1254, 2080, 3108], 'shift': [1258, 1739, 2396], 'way': [1261, 3192, 4239], 'health-oriented': [1263], 'done': [1268, 4306], 'future': [1271], 'Specifically,': [1273], 'NRC': [1275, 1342, 1371, 1416, 2581, 2944], 'concluded': [1276], 'existed': [1280], '"transform': [1282], 'system': [1287, 1306, 2809, 3865, 4052], 'whole': [1290], 'animal': [1291], 'founded': [1295], 'primarily': [1296], 'methods,"': [1300], 'envisioning': [1301], '"a': [1302], 'evaluates': [1308], 'biologically': [1309, 1614, 2440, 2849, 4087], 'perturbations': [1311, 1776, 2703, 2871, 3555], 'key': [1313, 1706, 1882, 2033, 2302, 2563, 2763, 3081, 3388, 3549], 'pathways"': [1315], 'combination': [1318], 'comprehensive': [1324], 'array': [1325], 'preferably': [1331], 'cells': [1333], 'tissues': [1335, 2719], 'origin': [1338], 'Although': [1340, 2073, 2345, 3301, 4001], 'did': [1343, 1353, 1372, 1667], 'not': [1344, 1678, 1869, 2077, 2338, 2509, 3033, 3686, 3738, 3954, 4123, 4286, 4390, 4544, 4613], 'advocate': [1345], 'eliminating': [1346], 'committee': [1352, 4488], 'recommend': [1354, 1373], 'relegating': [1355], 'role,': [1360], 'focused': [1361, 1704, 2275, 3401, 4053], 'specific': [1364, 1466, 1753, 2028, 3143, 3754, 3776], 'uncertainties': [1365], 'questions.': [1369], 'mechanistically': [1375, 1513], 'based,': [1376, 1514, 1615], 'primary': [1383, 1785], 'foundation': [1384, 2355, 4109], 'characterizing': [1386, 3730], 'dose–response': [1387, 2851], 'relationships': [1388, 2016, 3870, 3949], 'assessing': [1391], 'hazards.': [1392], 'Models': [1393, 2446], 'quantifiable': [1395], 'would': [1397, 2624, 2910, 4543], 'gradually': [1398], 'replace': [1399], 'factors': [1407], '11.': [1414], 'acknowledges': [1417], 'resources': [1420, 1459, 1473], 'will': [1421, 1460, 1474, 1656, 1818, 2076, 2092, 2665, 4130, 4147, 4165, 4256, 4326], 'required': [1423], 'fully': [1425, 1911], 'understand': [1426, 1763, 2774, 2833, 3541, 3813], 'pathways': [1428, 1804, 1841, 1970, 2457, 3898], 'develop': [1431, 1613, 1807, 1822, 2013, 2750, 3002, 4012, 4259], 'support': [1435, 1825, 2121, 2236, 4183, 4339, 4928], 'approach': [1442, 2318, 2361, 4041, 4241, 4713], 'reallocation': [1446], 'rather': [1449, 4173], 'than': [1450, 4174, 4303], 'hefty': [1452], 'costly': [1454], 'resources;': [1457], 'fewer': [1458], 'invested': [1462, 1476], 'relatively': [1468], 'chemicals,': [1470], 'making': [1478, 4311, 4519], 'effective': [1480, 1976], 'developing': [1487, 2042, 2556, 4315], 'knowledge': [1488, 1799, 2205, 3961, 3988, 4009], 'generalized': [1492], 'Our': [1496], 'increasing': [1497], 'tens,': [1501], 'hundreds,': [1502], 'thousands': [1504], 'targeted,': [1512], 'assays': [1517, 2217], 'manner': [1521], 'gives': [1522], 'potential': [1525, 2188, 2425, 2904, 3110, 3138, 3276, 3583, 3601, 3621, 3832], 'generate': [1527, 4166, 4288], 'wealth': [1529], 'toxicologically': [1531], 'relevant': [1532, 2087, 2169, 2919, 3370, 3409], 'manner.': [1537], 'Can': [1538, 3912, 4950], 'capitalize': [1540], 'adopt': [1545], 'interpret': [1551], 'quickly': [1555], 'screen': [1558], 'numbers': [1560], 'inform': [1564, 1972], 'management': [1566, 4264], 'decisions?': [1567], 'Challenges': [1568, 1732], 'Two': [1573], 'impede': [1575], 'ERA:': [1583], 'Linkage:': [1584, 1835], 'We': [1585, 1611, 1760, 4548], 'establish': [1587, 1957, 2756], 'credible': [1588, 1826, 4111], 'links': [1589, 1958, 2064], 'between': [1590, 1959, 3437, 3876], 'level': [1598, 2538, 2628, 3298, 3410, 3856], 'traditionally': [1602], 'whole-animal': [1606], 'population': [1608, 3277, 3334, 3372, 3422], 'level.': [1609, 3423], 'Extrapolation:': [1610, 2443], 'quantitative': [1616, 2014, 2247, 3097], 'allow': [1622], 'cell-': [1626], 'tissue-level': [1628], 'individuals,': [1631], 'individual-level': [1633], 'populations.': [1637], 'successfully': [1642], 'incorporate': [1643, 2826, 2882], 'wider': [1644], 'suborganismal': [1647, 2568], 'types': [1652, 2656, 3116, 3343, 3777], 'into': [1653, 2172, 2924, 3285, 3367, 3562, 3839, 3994], 'ERA,': [1654, 2089, 3360], 'challenges,': [1661], 'participants': [1666, 3204, 4422], 'their': [1669, 1675, 1967, 2063, 2501, 2812, 2868, 3361, 3712, 3797, 3965, 4539], 'plenary': [1670], 'discussions': [1671], 'workgroups.': [1673], 'Ultimately,': [1674], 'intent': [1676], 'was': [1677, 4441], 'consider': [1680, 2902], 'breadth': [1683], 'scientific': [1685, 2143, 2564, 4193, 4317, 4685], 'development': [1686, 1974, 2098, 2947, 4085], 'needed': [1687, 3019, 4010, 4792], 'achieve': [1691, 4434], 'something': [1692], 'akin': [1693], "NRC's": [1696, 4247], 'vision': [1697, 4248, 4363, 4384, 4426, 4665, 4885], 'toxicology;': [1701], 'rather,': [1702, 4291], 'limit': [1709], 'those': [1728, 1775, 2100, 2891, 3030, 3891, 4019], 'challenges.': [1729], 'Meeting': [1730, 1733, 1791, 4683], 'requires': [1740, 1795], 'moving': [1741], 'beyond': [1742, 1828], 'simply': [1743], 'determining': [1744], 'concentration': [1746, 3689], 'chemical': [1749, 2024, 2314, 2469, 2514, 2592, 2604, 2636, 2740, 2760, 2818, 3091, 3229, 3692, 3752, 3810, 3823, 3836, 4799], 'causes': [1751, 3693, 3783], 'outcome': [1755, 1803, 1840, 1865, 1875, 1939, 2256, 2431, 2452, 2533, 2549, 2642, 3291, 3428, 3445, 3679, 3925, 4922], 'wish': [1757], 'prevent.': [1759], 'also': [1761, 1794, 1877, 3016, 3363, 3698], 'adversely': [1766], 'affect': [1767], 'cellular': [1768, 2702], '(i.e.,': [1770], 'pathways),': [1772], 'extend': [1778], 'individuals': [1780], 'ultimately': [1782], 'unit': [1786], 'ERA—populations.': [1790], '(AOPs)': [1805], 'Finally,': [1814, 2229, 3262], 'meeting': [1815], 'constraints': [1830], 'themselves.': [1834], 'Adverse': [1836, 1839, 2255, 2451, 3427, 4921], 'Outcome': [1837], 'Pathways': [1838], 'represent': [1842], 'sequence': [1844, 1932, 3075, 3126, 3671], 'events': [1846, 1883, 1934, 2711, 2873, 3389, 3673], 'begins': [1848], 'initiating': [1852, 1879, 1995, 2068, 2190, 3440, 3746], 'event,': [1853], 'spans': [1854], 'multiple': [1855, 2903, 2934], 'levels': [1856, 2714, 2758], 'organization,': [1859], 'ends': [1861], '12.': [1866, 1909, 1963, 1987, 2488], 'By': [1867], 'describing': [1868], 'just': [1870], 'organism-': [1872], 'population-level': [1874], 'event': [1880, 1996, 2069, 3441], 'between,': [1885], 'AOPs': [1886, 1965, 2075, 2119, 2133, 2337, 2491, 2847, 3047, 3385, 4082, 4142], 'build': [1887, 2351, 3255], 'provide': [1893, 2598, 2997, 4022, 4346], 'conceptual': [1895, 2174, 3431, 4925], 'framework': [1896, 3432, 4926], 'facilitate': [1899, 2370, 2625, 2811], 'A': [1910, 2609, 3430, 3505, 4664, 4769, 4844, 4924], 'developed': [1912, 2114, 2129], 'AOP': [1913, 1999, 2055, 2175, 2208, 2379, 2428, 2507, 2864], 'synonymous': [1915], 'mechanism': [1918], 'action—a': [1920], 'complete': [1921], 'detailed': [1923, 3670], 'every': [1928, 4269], 'leading': [1935], '(http://www.ecetoc.org;': [1940], '4,': [1941], '12,': [1942, 2000], '13).': [1943], 'Where': [1944, 4333, 4358], 'gaps': [1945], 'exist': [1946], 'AOP,': [1949, 2930], 'weight': [1950], 'evidence': [1952], 'statistical': [1954], 'correlations': [1955], 'adversity': [1962, 2486], 'Defining': [1964], 'associated': [1968, 2136, 2196, 3049, 3184, 3774], 'hazard': [1984, 2495], 'identify': [1992, 3041, 3685, 3829], 'interaction': [2006, 3749], 'modeled': [2011], 'structure–activity': [2015], '(QSARs)': [2017], 'likelihood': [2021, 2601], 'interacting': [2025, 2935], 'target.': [2029], 'Similarly,': [2030, 3120], 'defining': [2031, 2074], 'pathway': [2035, 2257, 2694, 3349, 4058], 'provides': [2036], 'information': [2039, 3486, 3875, 3995, 4023, 4180, 4377], 'Biomarker': [2047], 'contextualized': [2052], 'gain': [2056], 'diagnostic': [2060, 2227], 'credibility': [2061], 'outcome.': [2072], 'render': [2078], 'QSARs,': [2081, 3461, 3764], 'biomarkers': [2086, 2225, 3111], 'process': [2091], 'greatly': [2093], 'aid': [2094], 'identification': [2096, 2186, 3079], 'truly': [2106], 'informative.': [2107], 'At': [2108, 3854, 3964], 'workshop,': [2111], 'groups': [2113], 'complementary': [2115, 2382], 'constructing': [2118], 'ecotoxicology.': [2123, 4437], 'Watanabe': [2124, 2346], 'et': [2125, 2271, 2347, 2365, 2795, 2962, 3152, 3156, 3163, 3268, 3399], 'al.': [2126, 2272, 2348, 2366, 2796, 2963, 3153, 3157, 3164, 3269, 3400], '(p.': [2127, 2273, 2797, 3165, 3271], '9)': [2128], 'strategies': [2130, 4707], 'deriving': [2132], 'designing': [2135], 'literature.': [2144], 'Participants': [2145], 'chose': [2146], 'domoic': [2147, 2181, 2259], 'acid': [2148, 2182], 'case': [2151, 3215], 'study,': [2152], 'given': [2153], 'ecotoxicological': [2155, 3593], 'significance': [2159, 3294], 'vast': [2162, 2610], 'body': [2163, 2611], 'literature,': [2166], 'synthesized': [2168], 'published': [2170], 'model.': [2176], 'well-known': [2178], 'poisoning': [2183], 'facilitated': [2184], 'events,': [2191], 'pathway,': [2194], '(Fig.': [2199, 2397, 3062, 3299], '1).': [2200], 'Furthermore,': [2201, 2529], 'showed': [2203], 'used': [2211, 3205, 3328, 3519, 5014], 'prospective': [2219, 2407, 2584, 2674, 4115], 'appropriate': [2224, 2557, 4079], 'assessments.': [2228, 2249, 5018], 'biomarker': [2244], 'Figure': [2250, 2399, 2659], '1Open': [2251], 'figure': [2253, 2402], 'viewerPowerPoint': [2254, 2403], 'acid.': [2260], '(Photo': [2261], 'Pseudo-nitzschia': [2263], 'courtesy': [2264], 'Rafael': [2266], 'Kudela)': [2267], 'Another': [2268], 'workgroup,': [2269], 'Perkins': [2270, 2364, 4554], '22),': [2274], 'technologies': [2278, 3071, 3172], 'application': [2281, 2502, 4017, 4080, 4140], 'ecotoxicogenomics.': [2283], 'demonstrated': [2285], 'ecotoxicogenomics': [2287], 'combined': [2290], 'bioinformatics': [2292], 'unsupervised': [2299], 'nodes': [2303], '(genes,': [2304], 'proteins,': [2305], 'metabolites)': [2307], 'physiological': [2310, 2835, 3218], 'functions': [2311, 3951], 'impacted': [2312], 'stressors.': [2315], 'threefold': [2317], 'forms': [2319], 'basis': [2321, 3251], 'reverse-engineering': [2323, 2360], 'elements': [2324, 3877], 'stressors': [2331, 3525], 'previously': [2339], 'elucidated': [2340], 'hypothesis-based': [2343], 'experimentation.': [2344], 'tremendous': [2354], 'existing': [2357, 2613, 3984], 'knowledge,': [2358], 'employed': [2362], 'poised': [2368], 'discoveries.': [2372], 'Thus,': [2373, 3397], 'general': [2376], 'brought': [2387, 3059], 'bear': [2389, 3061, 4405], 'challenge': [2392, 2801, 3175, 3404, 4282], '2).': [2398, 3063, 3300], '2Open': [2400], 'Proposed': [2404], 'schema': [2405, 4095, 4129], 'Dashed': [2415], 'red': [2416], 'lines': [2417, 2423], 'indicate': [2418, 2424], 'dominant': [2419], 'Black': [2422], 'approaches.': [2427], '=': [2429, 2434, 2439], 'pathway;': [2432], 'PBTK': [2433], 'physiologically': [2435], 'toxicokinetics;': [2437], 'BBDR': [2438, 2880, 2926, 2949, 2966, 2985], 'dose–response.': [2442], 'Tools': [2444], 'Support': [2448], 'Quantitative': [2449], 'pathways,': [2453], 'encompass,': [2459], 'assumption': [2464], 'disturbance': [2470], 'severe': [2472], 'enough': [2473], 'overwhelm': [2475], "organism's": [2477, 2526, 3137], 'adaptive': [2478, 2527], 'response': [2483, 2769, 3733, 3773, 3897], 'trajectory': [2484, 3921], 'such,': [2490], 'limited': [2499], 'An': [2506], 'does': [2508, 4612], 'account': [2510, 2855], 'contributions': [2512], 'dose': [2515], 'concentration,': [2517], 'timing': [2518], 'duration': [2520], 'exposure,': [2522, 3933], 'biotransformation,': [2523], 'capacity.': [2528], 'when': [2530, 3900], 'predicted': [2535, 2972, 3956], 'individual,': [2541], 'ERAs': [2543], 'populations': [2551], 'species.': [2554, 4987], 'Consequently,': [2555], 'constitutes': [2560], 'second,': [2562], 'alternative,': [2567], 'play': [2572], 'ERA.': [2578, 4000], 'characterization': [2593], 'modeling': [2596], 'estimated': [2600], 'reaching': [2605], 'target': [2607], 'organism.': [2608], 'research': [2614, 3594, 4930], 'addresses': [2615], 'questions': [2616, 2689, 3535], 'fate,': [2619], 'distribution,': [2620], 'characterization.': [2630], 'Once': [2631], 'disruption': [2637, 2905], 'leads': [2638, 3675], 'determined': [2645], 'likely,': [2648], 'next': [2650], 'logical': [2651], 'question': [2652, 2669], 'becomes': [2653, 2722], '"Under': [2654], 'conditions?"': [2658], '2': [2660, 4646], 'depicts': [2661], 'strategy': [2663], 'help': [2666, 4540], 'answer': [2667, 2687], 'outlining': [2671], 'steps': [2672, 3741], 'define': [2677], 'necessary': [2679], 'models.': [2683], 'Initial': [2684], 'attempts': [2685], 'consist': [2691], 'QSARs': [2697, 4838, 4856], 'determine': [2699, 2889, 3567], 'stressor': [2706], 'cause.': [2708], 'higher': [2713], 'organization': [2717, 3412], '(e.g.,': [2718, 3150, 3618], 'organs)': [2721], 'complicated': [2723], 'intricacies': [2726], 'systems.': [2729], 'animals': [2733], 'able': [2735, 3133], 'withstand': [2737], 'changes,': [2741], 'adaptability': [2744], 'further': [2745, 3234], 'confounds': [2746], 'simple': [2751], 'acceptable': [2757], 'exposure.': [2761, 3230], 'One': [2762], 'harnessing': [2766], 'suborganismal,': [2767], 'non-apical': [2768, 4104], 'better': [2773, 4301, 4758], 'robustness': [2776], 'systems—the': [2779], 'limitations—in': [2785], 'relation': [2786], 'varying': [2788, 3552], 'regimens.': [2790], 'workgroup': [2792, 2821, 3160, 3203, 3270], 'Nichols': [2794, 2961, 4908], '39)': [2798], 'addressed': [2799], 'examining': [2803], 'features': [2804], 'vertebrate': [2807], 'endocrine': [2808], 'adjustment': [2813, 2838], 'recovery': [2816], 'disturbances.': [2819], 'emphasized': [2822], 'mathematical': [2827, 3538], 'means': [2831, 4036], 'recovery.': [2840], 'Especially': [2841], 'pertinent': [2842], '(BBDR)': [2852], 'major': [2857], 'homeostasis': [2860], 'allostasis.': [2862], 'Unlike': [2863, 4154], 'restrict': [2867], 'lead': [2875], 'processes': [2884], 'variables': [2886, 3550], 'whether': [2890, 4273, 4274], 'apical': [2892, 3303], 'occur.': [2895], 'sites,': [2906], 'unique': [2913], 'AOP.': [2914], 'Identifying': [2915], 'parameterizing': [2917], 'let': [2931, 4230], 'alone': [2932, 4231], 'AOPs,': [2936, 3970], 'daunting': [2938], 'tasks.': [2939], 'reason,': [2942], 'views': [2945, 4620], '"longer-term': [2953], 'goal"': [2954], 'Nonetheless,': [2956, 4262], 'literature': [2958], 'reviewed': [2959], 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4949], 'drug': [4639, 5010], 'discovery.': [4640], 'Nat': [4641], 'Biotechnol': [4642], '22:': [4643], '1215–': [4644], '1217.': [4645], 'NRC.': [4656], '2007.': [4657, 4703], 'century:': [4663, 4774, 4882], 'strategy.': [4668], 'Academies': [4670, 4827], 'Press,': [4671, 4828], 'Washington,': [4672, 4806, 4829], 'DC.': [4673, 4830], '3': [4674], 'Bradbury': [4675], 'SP,': [4676], 'Feijtel': [4677], 'TC,': [4678], 'Van': [4679], 'Leeuwen': [4680], 'CJ.': [4681], 'Environ': [4695, 4740, 4934, 4988, 5019], 'Sci': [4696, 4741, 4780, 4889, 4989, 5020], 'Technol': [4697, 4990, 5021], '38:': [4698], '463A–': [4699], '470A.': [4700], 'ECETOC.': [4702], 'I': [4704], 'ntelligent': [4705], 'ecotoxicology:': [4709], 'specifically': [4715], 'acting': [4716], 'Technical': [4718], 'Report': [4719], '102.': [4720], 'Brussels,': [4721], 'Belgium.': [4722], '5': [4723], 'Ahlers': [4724], 'J,': [4725], 'Stock': [4726], 'F,': [4727], 'Werschkun': [4728], 'B.': [4729], '2008.': [4730, 4973, 5005], 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'W.': [4836], '2003.': [4837], 'world': [4841], 'wide': [4842], 'web:': [4843], 'quality': [4847], 'assurance': [4848], 'prevent': [4850], 'misuse.': [4851], 'JD': [4853], 'Walker,': [4854], 'ed,': [4855], 'Pollution': [4858], 'Prevention,': [4859], 'Screening,': [4861], 'Assessment,': [4863], 'Web': [4865], 'Applications.': [4866], 'SETAC,': [4867], 'Pensacola,': [4868], 'FL,': [4869], 'USA.': [4870], '11': [4871], 'Andersen': [4872], 'ME,': [4873, 4970], 'Krewski': [4874], 'D.': [4875], 'Bringing': [4883], 'life.': [4887], '107:': [4890], '324–': [4891], '330.': [4892], 'GT,': [4895], 'Bennett': [4896], 'RS,': [4897], 'Erickson': [4898], 'RJ,': [4899], 'Hoff': [4900], 'DJ,': [4901], 'Hornung': [4902], 'MW,': [4903], 'Johnson': [4904], 'RD,': [4905], 'Mount': [4906], 'DR,': [4907], 'JW,': [4909], 'Russom': [4910], 'CL,': [4911], 'Schmieder': [4912], 'PK,': [4913], 'Serrano': [4914], 'JA,': [4915, 4968], 'Tietge': [4916], 'JE,': [4917], 'DL.': [4919], '2010.': [4920], 'pathways:': 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