Title: Spontaneous activity of A9 and A10 dopamine neurons after acute and chronic administration of the selective dopamine D-1 receptor antagonist SCH 23390
Abstract: The effects of acute and chronic treatment with the selective dopamine (DA) D-1 antagonist SCH 23390 on the population response of midbrain DA cells were determined. One hour pretreatment with SCH 23390 (0.0125, 0.025, 0.05 mg/kg s.c.) caused a dose-related increase in the number of spontaneously firing DA neurons in both the A9 and A10 cell regions. Chronic (28 day) administration of SCH 23390 (0.05 mg/kg s.c.) caused depolarization inactivation of only A10 DA cells. These data suggest that SCH 23390 may have antipsychotic properties with a reduced likelihood of producing extrapyramidal side effects.
Publication Year: 1988
Publication Date: 1988-10-01
Language: en
Type: article
Indexed In: ['crossref', 'pubmed']
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Cited By Count: 20
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