A Mitogenic Action for Fibrinogen Mediated through Intercellular Adhesion Molecule-1

Name: Work Video:
Duration: 3 min 30 s
Elizabeth E. Gardiner; Stanley E. D’Souza
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2660, 2811, 2824, 2940, 3132, 3192, 3215, 3559, 3571, 3588, 3617, 3639, 3700, 3731, 4047, 4115, 4207, 4226, 4311, 4368, 4391, 4459, 4466, 4518], 'vascular': [24, 233, 443, 543], 'endothelium.': [25, 234], 'The': [26, 52, 89, 235, 261, 298, 546, 604, 971, 1391, 1493, 1521, 2174, 2336, 2384, 2543, 2573, 2765, 3043, 4409], 'plasma': [27, 236, 750, 774, 1955], 'protein': [28, 237, 751, 2089, 2805, 2890], 'fibrinogen': [29, 44, 81, 142, 173, 189, 204, 238, 253, 290, 351, 382, 398, 413, 1289, 2003, 3211, 4350], 'also': [31, 83, 134, 240, 292, 343, 2057, 3100, 3683], 'been': [32, 241, 674, 797, 943, 978, 1021, 1404, 2976, 3855, 4413], 'shown': [33, 242, 1022], 'interact': [35, 244], 'with': [36, 125, 158, 172, 179, 183, 245, 334, 367, 381, 388, 392, 752, 975, 1113, 1140, 1387, 1694, 1706, 1738, 1854, 2115, 2228, 2311, 2405, 2638, 2761, 2859, 2869, 2888, 2893, 2951, 3059, 3081, 3191, 3201, 3649, 3947, 3949, 4021, 4190, 4259, 4384], 'ICAM-1.': [37, 109, 246, 318, 1269, 1390, 1492, 2572, 2876, 4375], 'We': [38, 247], 'have': [39, 248, 483, 673, 796, 1020, 3883], 'investigated': [40, 249, 4366], 'effect': [42, 251, 1145, 4144, 4516], 'of': [43, 54, 64, 108, 114, 141, 252, 263, 273, 317, 323, 350, 548, 601, 637, 671, 680, 773, 804, 806, 853, 860, 863, 882, 892, 937, 973, 989, 1083, 1101, 1110, 1153, 1268, 1338, 1384, 1491, 1627, 1697, 1754, 1813, 1887, 1925, 2000, 2054, 2062, 2082, 2084, 2091, 2103, 2177, 2197, 2256, 2265, 2289, 2304, 2314, 2339, 2343, 2388, 2440, 2529, 2571, 2576, 2615, 2656, 2664, 2730, 2733, 2750, 2767, 2779, 2784, 2813, 2844, 2878, 2881, 2898, 2912, 2938, 2942, 2985, 2988, 3045, 3076, 3084, 3094, 3105, 3148, 3170, 3208, 3603, 3614, 3627, 3638, 3641, 3688, 3694, 3703, 3730, 3742, 3845, 3934, 3953, 3967, 3975, 4046, 4056, 4065, 4070, 4102, 4118, 4135, 4151, 4154, 4183, 4206, 4213, 4229, 4234, 4239, 4272, 4274, 4290, 4319, 4382, 4393, 4401, 4404, 4470, 4501], 'binding': [45, 254, 612, 1085, 3693, 3851, 3927, 3933, 4050, 4057, 4081, 4093, 4105, 4418], 'ICAM-1-expressing': [47, 256, 1620, 1765], 'cells': [48, 156, 257, 365, 710, 1027, 1192, 1623, 1626, 1653, 1672, 1767, 2622, 2830, 2863, 2882, 3046, 3596, 3646, 4023], 'on': [49, 143, 258, 352, 550, 676, 1237, 1677, 2070, 2253, 2301, 2349, 2718, 3219, 3644, 4059, 4361, 4372, 4517], 'proliferation.': [51, 208, 260, 417, 4287], 'inclusion': [53, 262, 4150], '200–800': [55, 264], 'nmfibrinogen': [56, 146, 265, 355], 'but': [57, 161, 266, 370, 3970, 4327], 'not': [58, 162, 267, 371, 3724, 3971, 4160, 4278, 4328], 'fibronectin': [59, 268, 1332, 4156], 'culture': [62, 271, 1771, 1781, 4116, 4258], 'medium': [63, 272, 1683, 1782, 1812, 1893, 2364, 2835, 2959, 4117, 4197, 4216, 4243, 4260], 'Raji': [65, 93, 274, 302, 1622, 1636, 1777, 2827, 3019, 3085, 3589, 3615, 3682, 3695, 3838, 3853, 3887, 3938, 3948, 4022, 4060, 4166, 4184, 4192, 4214, 4230, 4240, 4251, 4297, 4326, 4362, 4373, 4383], 'induced': [66, 147, 275, 356, 4176, 4284, 4293], '2–4-fold': [68, 277], 'increase': [69, 150, 278, 359, 4179, 4249], '[3H]thymidine': [71, 152, 280, 361, 2899, 4136, 4405], 'incorporation': [72, 153, 281, 362, 4134, 4403], 'after': [73, 282, 4185, 4220, 4254], '8': [74, 283, 4186, 4221, 4255], 'h.': [75, 284, 2934, 4222], 'Cell': [76, 285, 659, 2447, 2902, 3179, 3755], 'proliferation': [77, 286], 'cultures': [79, 288, 4193, 4238], 'containing': [80, 116, 289, 325, 1645, 1662, 1708, 1818, 1894, 2271, 2319, 2324, 2365, 2602, 2736, 2755, 3038, 3101, 3159, 4171, 4217, 4244, 4261], 'was': [82, 94, 133, 291, 303, 342, 1106, 1320, 1356, 1395, 1510, 1543, 1788, 1937, 1950, 2045, 2113, 2180, 2185, 2223, 2248, 2284, 2390, 2513, 2561, 2582, 2587, 2605, 2667, 2770, 2807, 2981, 3048, 3126, 3195, 3891, 3921, 3939, 4112, 4123, 4145, 4231, 4263, 4310, 4323, 4374], 'confirmed': [84, 293, 2668, 3922], 'by': [85, 96, 154, 294, 305, 363, 558, 874, 1108, 1322, 1512, 1736, 1760, 1773, 1783, 1956, 2068, 2250, 2293, 2347, 2515, 2607, 2669, 2776, 2823, 2960, 2983, 3135, 3214, 3577, 3696, 3858, 3964, 4133, 4211, 4265, 4270, 4406], 'direct': [86, 295, 929, 1147, 4266], 'counting.': [88, 297], 'proliferative': [90, 139, 299, 348, 4163], 'response': [91, 300, 1223, 1245, 4164, 4295], 'abrogated': [95, 304, 1107, 4077], 'an': [97, 184, 306, 393, 532, 748, 1484, 2262, 2845, 3067, 3145, 3220, 3965, 3972], 'anti-ICAM-1': [98, 307, 1392, 1494, 1876, 3068, 3618, 4073, 4387], 'mAb': [99, 308, 1393, 1495, 1739, 1861, 1870, 1873, 3619, 3654, 4087, 4388, 4410, 4510], '84H10': [100, 309, 1394, 3070, 4075, 4389, 4411, 4462], 'which': [101, 310, 1135, 1218, 2522, 2560, 3634, 4061], 'maps': [102, 311], 'first': [105, 118, 314, 327, 605, 887, 982, 1265, 1488, 2567, 4467], 'Ig': [106, 315, 1489, 2569, 4468], 'domain': [107, 316, 636, 984, 1267, 1490, 2662, 4469], 'A': [110, 319, 928, 1093, 2065, 2105, 2438, 3929, 4247, 4305, 4314], 'purified': [111, 320, 1333, 1377, 1698, 1951, 2219, 2249, 2606, 2713, 2785, 3576, 4109, 4155], 'truncated': [112, 321], 'form': [113, 322, 891, 2387, 2663], 'ICAM-1': [115, 131, 159, 202, 324, 340, 368, 411, 529, 549, 588, 638, 672, 932, 976, 990, 1087, 1117, 1141, 1231, 1709, 1733, 1755, 2389, 2511, 2658, 2665, 2708, 2711, 2743, 2769, 2787, 3209, 3228, 3538, 3628, 3642, 4352, 4358, 4471], 'two': [119, 328, 606, 861, 2568, 2661], 'Ig-like': [120, 329, 592, 607, 635, 983, 1266], 'domains': [121, 330, 593, 608, 2570], 'peptide': [124, 182, 333, 391], 'amino': [126, 185, 335, 394, 986, 1255, 3202], 'acid': [127, 186, 336, 395, 1256, 2992, 3000, 3203], 'sequence': [128, 187, 337, 396, 2575], 'corresponding': [129, 338, 3205], '(8–22)': [132, 341], 'able': [135, 344, 767, 1143, 2808], 'block': [137, 346, 1407, 4416], 'action': [140, 349, 881], 'Raji.': [144, 353, 3739, 4095, 4107], '200': [145, 354, 4172, 4394], '3-fold': [149, 358], '293': [155, 165, 364, 374, 1625, 1652, 1671, 1766, 2829], 'transfected': [157, 366, 1689, 1705], 'cDNA': [160, 369, 1710, 2512, 2531, 2537, 2564], 'control': [163, 372, 1857, 2870, 4191], 'non-transfected': [164, 373], 'cells.': [166, 375, 2620, 4408], 'Comparable': [167, 376], 'mitogenic': [168, 377, 1159, 1234, 1244, 4312, 4316, 4369], 'effects': [169, 378], 'were': [170, 379, 1275, 1283, 1374, 1571, 1593, 1610, 1632, 1637, 1654, 1673, 1687, 1734, 1757, 1768, 1778, 1836, 1846, 1882, 1909, 1930, 2056, 2108, 2328, 2345, 2354, 2623, 2712, 2740, 2745, 2788, 2831, 2852, 2864, 2886, 2906, 2924, 2945, 2955, 3002, 3020, 3057, 3079, 3114, 3212, 3227, 3556, 3575, 3584, 3834, 4097], 'achieved': [171, 380, 4210], 'fragments': [174, 383, 903, 1152, 2200], 'X': [175, 384, 896], 'D100,': [177, 386], 'synthetic': [181, 390], 'matching': [188, 397], 'γ': [190, 399, 867, 940, 1261], 'chain': [191, 400, 941, 1262, 2517, 2579], '(117–133).': [192, 401], 'These': [193, 402, 3582], 'results': [194, 403, 4300], 'indicate': [195, 404], 'that': [196, 405, 1105, 1137, 1230, 1241, 1480, 1996, 2974, 3886, 4235, 4281, 4308, 4380], 'interaction': [197, 406, 930, 972], 'between': [198, 407, 931, 1026], 'discrete': [199, 408, 935, 1254], 'sequences': [200, 409, 1257, 2549, 3204, 3226], 'within': [201, 410, 712, 1258, 1486, 4465], 'result': [205, 414], 'cellular': [207, 416, 1222, 2849, 2979, 4286], 'Fibrinogen': [418], '(Fg)': [419], '1The': [420], 'abbreviations': [421], 'used': [422, 2098, 2612], 'are:': [423], 'Fg,': [424], 'fibrinogen;': [425], 'ICAM-1,': [426, 3604], 'intercellular': [427, 455], 'molecule-1;': [429, 446], 'mAb,': [430], 'monoclonal': [431], 'antibody;': [432], 'IMDM,': [433], "Iscove's": [434, 2360], 'modified': [435, 1658, 2361], "Dulbecco's": [436, 1657, 1792, 2362], 'medium;': [437], 'FACS,': [438], 'fluorescence-activated': [439, 1749], 'sorting;': [441], 'VCAM-1,': [442], 'FCS,': [447], 'fetal': [448], 'calf': [449], 'serum;': [450], 'FITC,': [451], 'fluorescein': [452], 'isothiocyanate.': [453], 'are': [460, 609, 766, 1155, 3606, 4353], 'prominent': [461], 'ligands': [462], 'several': [464], 'integrin': [465, 1564, 1582, 1591, 3064, 3732, 4086, 4509], 'receptor': [466, 1236, 4318, 4371], 'subclasses': [467], '(1Hynes': [468], 'R.O.': [469], 'Cell.': [470, 517, 620, 1042, 1467, 2156, 3525, 4006, 4488], '1992;': [471, 741, 844, 1468, 2502, 3256, 3309, 3526, 4489], '69:': [472], '11-25Abstract': [473], 'Full': [474, 521, 624, 961, 963, 1007, 1009, 1046, 1070, 1072, 1310, 1312, 1471, 1721, 1723, 1971, 2032, 2034, 2132, 2160, 2213, 2425, 2427, 2697, 2699, 3330, 3332, 3356, 3358, 3445, 3447, 3529, 3672, 3674, 3806, 3824, 3826, 3909, 3911, 4010, 4343, 4492], 'Text': [475, 522, 625, 962, 964, 1008, 1010, 1047, 1071, 1073, 1311, 1313, 1472, 1722, 1724, 1972, 2033, 2035, 2133, 2161, 2214, 2426, 2428, 2698, 2700, 3331, 3333, 3357, 3359, 3446, 3448, 3530, 3673, 3675, 3807, 3825, 3827, 3910, 3912, 4011, 4344, 4493], 'PDF': [476, 523, 626, 965, 1011, 1048, 1074, 1314, 1473, 1725, 1973, 2036, 2134, 2162, 2215, 2429, 2701, 3334, 3360, 3449, 3531, 3676, 3808, 3828, 3913, 4012, 4345, 4494], 'PubMed': [477, 498, 524, 567, 583, 627, 664, 705, 724, 786, 824, 923, 966, 1012, 1049, 1075, 1130, 1184, 1211, 1315, 1351, 1421, 1446, 1474, 1505, 1538, 1726, 1974, 1988, 2037, 2135, 2163, 2216, 2430, 2485, 2505, 2702, 3184, 3238, 3269, 3289, 3335, 3361, 3378, 3399, 3422, 3450, 3464, 3479, 3504, 3532, 3677, 3760, 3791, 3809, 3829, 3876, 3914, 4013, 4040, 4346, 4429, 4453, 4495], 'Scopus': [478, 499, 525, 568, 584, 628, 665, 725, 787, 924, 967, 1013, 1050, 1076, 1131, 1185, 1316, 1352, 1422, 1447, 1475, 1506, 1539, 1727, 1989, 2038, 2164, 2431, 2486, 2506, 2703, 3185, 3239, 3270, 3336, 3362, 3379, 3400, 3451, 3465, 3480, 3505, 3533, 3678, 3761, 3792, 3830, 3877, 3915, 4014, 4041, 4430, 4454, 4496], '(9014)': [479], 'Google': [480, 501, 527, 570, 586, 630, 667, 706, 727, 744, 789, 825, 847, 926, 969, 1015, 1052, 1078, 1133, 1187, 1212, 1318, 1354, 1424, 1449, 1477, 1508, 1541, 1729, 1975, 1991, 2040, 2136, 2166, 2217, 2433, 2488, 2508, 2705, 3187, 3241, 3259, 3272, 3290, 3312, 3338, 3364, 3381, 3402, 3423, 3453, 3467, 3482, 3507, 3535, 3680, 3763, 3794, 3810, 3832, 3879, 3917, 4016, 4043, 4347, 4432, 4456, 4498], 'Scholar)': [481, 1188, 1319, 1355, 1509, 1542, 2167, 3536, 3833, 4017], 'important': [484], 'roles': [485], 'facilitating': [487], 'cell-cell': [488], 'associations': [489], 'adhesions': [491], '(2Springer': [492, 561], 'T.A.': [493, 562, 619, 657, 1435, 2141, 3493, 4442], 'Nature.': [494, 563, 1126, 1417, 1442, 3374, 3475, 3500, 4425, 4449], '1990;': [495, 564, 661, 4340], '346:': [496, 565], '425-434Crossref': [497, 566], '(5852)': [500, 569], 'Scholar,': [502, 571, 826, 1053, 1425, 1450, 2137, 2460, 2489, 3242, 3260, 3273, 3291, 3313, 3339, 3365, 3382, 3403, 3424, 3454, 3468, 3483, 3508, 3764, 3795, 3811], '3Languino': [503], 'L.R.': [504, 954, 1029, 1063, 3323, 3993], 'Plescia': [505, 949, 1030, 1058, 3318, 3994], 'J.': [506, 579, 653, 658, 699, 739, 842, 950, 955, 1001, 1031, 1059, 1064, 1121, 1173, 1206, 1304, 1324, 1347, 1715, 1965, 2026, 2126, 2207, 2419, 2468, 2495, 2691, 3177, 3254, 3307, 3319, 3324, 3350, 3369, 3388, 3417, 3439, 3460, 3666, 3754, 3800, 3815, 3818, 3865, 3903, 3995, 4029, 4334, 4337], 'Duperray': [507, 947, 1032, 1056, 3316, 3996], 'A.': [508, 810, 948, 1033, 1057, 1171, 1180, 1198, 1345, 1454, 1534, 2481, 3175, 3275, 3317, 3386, 3395, 3409, 3458, 3512, 3787, 3863, 3872, 3997, 4027, 4036, 4336, 4475], 'Brian': [509, 1034, 3998], 'A.A.': [510, 1035, 1200, 3411, 3999], 'Plow': [511, 1036, 1713, 2124, 2152, 3816, 4000], 'E.F.': [512, 1037, 1714, 2125, 2153, 3817, 4001], 'Geltosky': [513, 1038, 4002], 'J.E.': [514, 1039, 4003], 'Altieri': [515, 1040, 4004], 'D.C.': [516, 946, 1041, 1055, 3315, 3747, 4005], '1993;': [518, 1043, 1208, 3419, 4007], '73:': [519, 1044, 4008], '1423-1434Abstract': [520, 1045, 4009], '(303)': [526, 1051, 4015], 'Scholar).': [528, 587, 668, 745, 790, 848, 927, 970, 1079, 1730, 1992, 2509, 2706, 3188, 3681, 3918, 4044, 4348, 4499], 'functions': [530], 'as': [531, 2286, 2678, 2774, 3568, 3594, 4131, 4149, 4188], 'adhesive': [533], 'leukocytic': [536], 'β2integrins': [537], 'mediates': [539, 1220], 'extravasation': [541], 'across': [542], 'endothelial': [544, 709, 3645], 'barriers.': [545], 'expression': [547, 1756, 3602, 3626, 3687], 'endothelium': [551, 677, 683, 1104], 'controlled': [553], 'at': [554, 1249, 1840, 1848, 1914, 2092, 2189, 2225, 2381, 2798, 2926, 2996, 3119, 3137, 3167], 'least': [555, 1250, 2093], 'part': [557, 1252], 'inflammatory': [559], 'cytokines': [560], '4Albelda': [572], 'S.M.': [573], 'Smith': [574, 2154, 2436], 'C.W.': [575], 'Ward': [576], 'P.A.': [577, 1458, 3516, 3776, 4479], 'FASEB': [578], '1994;': [580, 702, 2157], '8:': [581], '504-512Crossref': [582], '(955)': [585], 'five': [590], 'extracellular': [591], 'numerousN-glycosylations': [595], 'contributing': [596], 'molecular': [599, 854, 2337], 'mass': [600, 855], '95': [602], 'kDa.': [603], 'critical': [610], '(LFA-1)': [615], '(5Marlin': [616], 'S.D.': [617, 3778], 'Springer': [618, 656, 1434, 3492, 4441], '1987;': [621, 1535, 3803], '51:': [622], '813-819Abstract': [623], '(1413)': [629], 'Scholar),': [631, 707, 1016, 1134, 1478, 2041, 2218, 3880, 4457], 'whereas': [632], 'third': [634], 'binds': [639], '(Mac-1)': [642], '(6Diamond': [643], 'M.S.': [644], 'Staunton': [645], 'D.E.': [646, 2147], 'de': [647], 'Fougerolles': [648], 'A.R.': [649, 1452, 3510, 4473], 'Stacker': [650], 'S.A.': [651, 1981], 'Garcia-Aguilar': [652], 'Hibbs': [654], 'M.L.': [655, 1202, 1433, 3413, 3491, 4440], 'Biol.': [660, 956, 1002, 1065, 1305, 1716, 1966, 2027, 2127, 2208, 2420, 2692, 3325, 3351, 3440, 3667, 3756, 3801, 3819, 3904, 4338], '111:': [662], '3129-3139Crossref': [663], '(778)': [666], 'Elevated': [669], 'levels': [670, 3640, 3729, 3741, 4273], 'detected': [675, 1735, 1931], 'lining': [678], 'regions': [679, 873, 3207], 'inflamed': [681], 'tissues,': [682], 'experiencing': [684], 'shear': [685], 'stress': [686], '(7Nagel': [687], 'T.': [688, 1361], 'Resnick': [689], 'N.': [690, 1466, 3524, 4487], 'Atkinson': [691], 'W.J.': [692], 'Dewey': [693], 'Jr.,': [694, 697, 718, 812, 3232, 3277], 'C.F.': [695], 'Gimbrone': [696, 717, 3231], 'M.A.': [698, 719, 3233], 'Clin.': [700], 'Invest.': [701], '94:': [703], '885-891Crossref': [704], 'present': [711, 4360], 'atherosclerotic': [713, 807], 'lesions': [714, 808], '(8Cybulsky': [715, 3229], 'M.I.': [716, 3230], 'Science.': [720, 3234], '1991;': [721, 3235, 3788], '251:': [722, 3236], '788-791Crossref': [723, 3237], '(1399)': [726, 3240], 'Scholar,9van': [728], 'der': [729, 3244], 'Wal': [730, 3245], 'A.C.': [731, 3246], 'Das': [732, 3247], 'P.I.': [733, 3248], 'Tigges': [734, 3249], 'A.J.': [735, 3250], 'Becker': [736, 3251], 'A.E.': [737, 3252], 'Am.': [738, 841, 3253, 3306], 'Pathol.': [740, 843, 3255, 3308], '141:': [742, 845, 3257, 3310], '1427-1433PubMed': [743, 3258], 'Fg': [746, 763, 791, 793, 849, 884, 893, 902, 910, 939, 974, 1084, 1138, 1150, 1154, 1219, 1235, 1260, 1949, 2055, 2112, 2179, 2184, 2199, 2220, 2281, 2325, 2344, 3078, 3108, 3541, 3544, 3547, 3552, 3708, 3850, 3890, 3926, 3936, 3945, 3969, 4019, 4049, 4080, 4092, 4104, 4111, 4148, 4174, 4262, 4282, 4292, 4309, 4317, 4370], 'abundant': [749], 'well': [754, 2944], 'recognized': [755], 'blood': [758, 2816], 'coagulation': [759], 'hemostasis.': [761], 'Both': [762], 'fibrin': [765, 2001], 'bind': [769, 3707], 'variety': [772], 'matrix': [776], 'proteins': [777, 2744, 3745], '(10Doolittle': [778, 915], 'R.F.': [779, 916, 1977, 3262], 'Annu.': [780, 917, 3263], 'Rev.': [781, 918, 3264], 'Biochem.': [782, 919, 1346, 1983, 2498, 3265, 3459], '1984;': [783, 920, 3266], '53:': [784, 921, 3267], '195-229Crossref': [785, 922, 3268], '(526)': [788, 925, 3271], 'degradation': [794], 'products': [795, 2342], 'localized': [798, 979], 'early': [800], 'late': [802], 'stages': [803], 'formation': [805], '(11Bini': [809], 'Fenoglio': [811, 3276], 'J.J.': [813, 3278], 'Mesa-Tejada': [814, 3279], 'R.': [815, 828, 1123, 1514, 2472, 3280, 3293, 3371, 3749], 'Kudryk': [816, 839, 3281, 3304], 'B.': [817, 1416, 3282, 3474, 3768, 4424], 'Kaplan': [818, 3283], 'K.L.': [819, 3284], 'Arteriosclerosis.': [820, 3285], '1989;': [821, 1502, 3286], '9:': [822, 3287], '109-121Crossref': [823, 3288], '12Valenzuela': [827, 3292], 'Shainoff': [829, 1325, 1963, 2205, 3294], 'J.R.': [830, 1291, 1964, 2013, 2206, 3295, 3426], 'DiBello': [831, 1294, 2016, 3296, 3429], 'P.M.': [832, 1295, 2017, 3297, 3430, 3751], 'Urbanic': [833, 3298], 'D.A.': [834, 1527, 3299, 3797], 'Anderson': [835, 3300], 'J.M.': [836, 3301], 'Matsueda': [837, 3302], 'G.R.': [838, 1500, 3303], 'B.J.': [840, 3305], '861-880PubMed': [846, 3311], 'homodimer': [852], '340': [856], 'kDa,': [857], 'made': [858], 'up': [859], 'sets': [862], 'α,': [864], 'β,': [865], 'polypeptide': [868], 'chains': [869], 'linked': [870], 'through': [871, 1217, 1884, 3144], 'N-terminal': [872], 'interchain': [875], 'disulfide': [876], 'bonds.': [877], 'Upon': [878], 'proteolytic': [880], 'plasmin,': [883], 'cleaved': [886, 3557], '260-kDa': [890], 'termed': [894], 'fragment': [895, 911, 2247, 2282, 2290, 2326], 'subsequently': [898], 'smaller': [900], 'C-terminal': [901], 'D': [904, 2291], '(100': [905], 'kDa)': [906, 914], 'central': [909], 'E': [912, 2283, 2327], '(50': [913], 'region': [936, 2528, 2534], 'demonstrated': [944, 1156, 3684, 3885], '(13Altieri': [945], 'Thornton': [951, 1060, 3320], 'G.B.': [952, 1061, 1293, 2015, 3321, 3428], 'Languino': [953, 1062, 3322], 'Chem.': [957, 1003, 1066, 1306, 1717, 1967, 2028, 2128, 2209, 2421, 2693, 3326, 3352, 3441, 3668, 3802, 3820, 3905, 4339], '1995;': [958, 1067, 3327], '270:': [959, 1068, 3328], '696-699Abstract': [960, 1069, 3329], '(97)': [968, 1077, 3337], 'incorporating': [985], 'acids': [987], '8–21': [988], "(14D'Souza": [991, 2409, 2681, 3656, 3893], 'S.E.': [992, 2139, 2410, 2682, 3341, 3657, 3894], 'Byers-Ward': [993, 2144, 2411, 2683, 3342, 3658, 3895], 'V.J.': [994, 1962, 2204, 2412, 2684, 3343, 3659, 3896], 'Gardiner': [995, 2413, 2685, 3344, 3660, 3897], 'E.E.': [996, 2414, 2686, 3345, 3661, 3898], 'Wang': [997, 2415, 2687, 3346, 3662, 3899], 'H.': [998, 1303, 2025, 2416, 2470, 2688, 3347, 3438, 3663, 3900], 'Sung': [999, 2417, 2689, 3348, 3664, 3901], 'S.-S.': [1000, 2418, 2690, 3349, 3665, 3902], '1996;': [1004, 1127, 1307, 1718, 2029, 2422, 2694, 3353, 3375, 3442, 3669, 3906], '271:': [1005, 1308, 1719, 2030, 2423, 2695, 3354, 3443, 3670, 3907], '24270-24277Abstract': [1006, 2424, 2696, 3355, 3671, 3908], '(30)': [1014, 2432, 2704, 3363, 3679, 3916], 'Fg:ICAM-1': [1018, 3848], 'interactions': [1019, 1410, 3991, 4020], 'mediate': [1024], 'contact': [1025], '(3Languino': [1028, 3992], '13Altieri': [1054, 3314], 'However,': [1080], 'consequences': [1082, 4101], 'may': [1088], 'be': [1089, 1247, 2821, 3725, 3961], 'even': [1090], 'more': [1091], 'direct.': [1092], 'recent': [1094], 'report': [1095, 1227], 'described': [1097, 2679, 3569], 'Fg-mediated': [1099, 4227], 'vasorelaxation': [1100], 'saphenous': [1102], 'vein': [1103], 'treatment': [1109, 3648], 'tissue': [1112], 'antibodies': [1114, 1370, 1901, 1929, 2677, 2871, 2873, 3697], 'directed': [1115, 1561, 1580, 2874, 3698], 'against': [1116, 1562, 1581, 1589, 1604, 2171, 2278, 2331, 2875, 3699], '(15Hicks': [1118], 'R.C.J.': [1119, 3367], 'Golledge': [1120, 3368], 'Mir-Hasseine': [1122, 3370], 'Powell': [1124, 3372], 'J.T.': [1125, 3373], '379:': [1128, 3376], '818-820Crossref': [1129, 3377], '(50)': [1132, 3380], 'suggests': [1136], 'association': [1139, 3959], 'physiological': [1148], 'response.': [1149], 'induce': [1158, 4161], 'activity': [1160, 2176], 'T': [1162], 'B': [1164, 1238, 2067, 2107, 3590, 3839], 'lymphocyte': [1165, 1409, 3591], 'lines': [1167], '(16Lévesque': [1168, 3860, 4024], 'J.-P.': [1169, 1196, 3173, 3384, 3407, 3861, 4025, 4332], 'Hatzfeld': [1170, 1172, 1197, 1205, 3174, 3176, 3385, 3387, 3408, 3416, 3862, 3864, 4026, 4028, 4333, 4335], 'Proc.': [1174, 1528, 2475, 3389, 3781, 3866, 4030], 'Natl.': [1175, 1529, 2476, 3390, 3782, 3867, 4031], 'Acad.': [1176, 1530, 2477, 3391, 3783, 3868, 4032], 'Sci.': [1177, 1531, 2478, 3392, 3784, 3869, 4033], 'U.': [1178, 1532, 2479, 3393, 3785, 3870, 4034], 'S.': [1179, 1441, 1533, 2480, 3394, 3499, 3772, 3786, 3871, 4035, 4448], '1986;': [1181, 3396, 3873, 4037], '83:': [1182, 3397, 3874, 4038], '6494-6498Crossref': [1183, 3398, 3875, 4039], '(27)': [1186, 3401, 3878, 4042], 'hematopoietic': [1190], 'progenitor': [1191], '(17Zhou': [1193], 'Y.Q.': [1194, 3405], 'Lévesque': [1195, 3406], 'Cardoso': [1199, 3410], 'Li': [1201, 3412], 'Sansilvestri': [1203, 3414], 'P.': [1204, 1439, 3415, 3497, 4446], 'Blood.': [1207, 3418], '82:': [1209, 2483, 3420], '800-806Crossref': [1210, 3421], 'Scholar);': [1213], 'however,': [1214, 3692], 'mechanism': [1216], 'this': [1221, 1481, 2804, 3958], 'remains': [1224], 'unclear.': [1225], 'This': [1226, 1401, 3919, 3977, 4143, 4201], 'provides': [1228], 'evidence': [1229], 'lymphocytes,': [1239], 'observed': [1243, 3940, 4236], 'can': [1246], 'attributed': [1248], 'Transferrin': [1270], 'bovine': [1272, 1832, 3040], 'serum': [1273, 1383, 1833, 3041], 'albumin': [1274], 'purchased': [1276], 'from': [1277, 1284, 1359, 1381, 1396, 1546, 1573, 1595, 1611, 1634, 1702, 1770, 1780, 1952, 2002, 2714, 2957, 3128, 3558, 4325], 'Sigma.': [1278], '125I-Sodium': [1279], 'iodide': [1280], '[methyl-3H]thymidine': [1282], 'Amersham': [1285], 'Life': [1286], 'Sciences.': [1287], 'Fibrin-free': [1288], '(18Shainoff': [1290, 2012], 'Smejkal': [1292, 2014, 3427], 'Mitkevich': [1296, 2018, 3431], 'O.V.': [1297, 2019, 3432], 'Levy': [1298, 2020, 3433], 'P.J.': [1299, 2021, 3434], 'Dempfle': [1300, 2022, 3435], 'C.E.': [1301, 2023, 3436], 'Lill': [1302, 2024, 3437], '24129-24137Abstract': [1309, 2031, 3444], '(29)': [1317, 2039, 3452], 'provided': [1321, 1511, 3841], 'Dr.': [1323, 1360, 1513, 1547], '(Cleveland': [1326, 1363], 'Clinic': [1327, 1364], 'Foundation,': [1328, 1365], 'Cleveland,': [1329, 1366], 'OH).': [1330, 1367], 'Human': [1331], 'according': [1334], 'method': [1337, 1693, 3218], 'Vuento': [1339], 'Vaheri': [1341], '(19Vuento': [1342], 'M.': [1343, 3456], 'Vahery': [1344, 3457], '1979;': [1348, 3461], '183:': [1349, 3462], '331-337Crossref': [1350, 3463], '(410)': [1353, 3466], 'gift': [1358, 1545], 'Ugarova': [1362], 'Anti-ICAM-1': [1368], 'polyclonal': [1369], 'R686': [1371], 'R803': [1373], 'prepared': [1375], 'our': [1379], 'laboratory': [1380], 'rabbits': [1385], 'injected': [1386], 'Escherichia': [1388], 'coli-expressed': [1389], 'AMAC': [1397], 'International': [1398, 1575], '(Westbrook,': [1399], 'ME).': [1400], 'antibody': [1402, 1482, 1523, 3065, 3069, 4074], 'reported': [1405, 3705, 3857, 3988, 4414], 'αLβ2/ICAM-1-mediated': [1408], '(20Simmons': [1411, 4419], 'D.': [1412, 1548, 1979, 3470, 4420], 'Makgoba': [1413, 3471, 4421], 'M.W.': [1414, 1427, 3472, 3485, 4422, 4434], 'Seed': [1415, 3473, 4423], '1988;': [1418, 1443, 3476, 3501, 3757, 4426, 4450], '331:': [1419, 1444, 3477, 3502, 4427, 4451], '624-627Crossref': [1420, 3478, 4428], '(506)': [1423, 1448, 3481, 3506, 4431, 4455], '21Makgoba': [1426, 3484], 'Sanders': [1428, 3486, 4435], 'M.E.': [1429, 3487, 4436], 'Luce': [1430, 3488, 4437], 'G.E.G.': [1431, 3489, 4438], 'Dustin': [1432, 3490, 4439], 'Clark': [1436, 3494, 4443], 'E.A.': [1437, 3495, 4444], 'Mannoni': [1438, 3496, 4445], 'Shaw': [1440, 3498, 4447], '86-88Crossref': [1445, 3503, 4452], '22Berendt': [1451, 3509], 'McDowall': [1453, 3511, 4474], 'Craig': [1455, 3513, 4476], 'A.G.': [1456, 3514, 4477], 'Bates': [1457, 3515, 4478], 'Sternberg': [1459, 3517, 4480], 'M.J.E.': [1460, 3518, 4481], 'Marsh': [1461, 3519, 4482], 'K.': [1462, 3520, 3813, 4483], 'Newbold': [1463, 3521, 4484], 'C.I.': [1464, 3522, 4485], 'Hogg': [1465, 3523, 4486], '68:': [1469, 3527, 4490], '71-81Abstract': [1470, 3528, 4491], '(229)': [1476, 3534, 4497], 'indicating': [1479], 'recognizes': [1483], 'epitope': [1485, 4460], 'QE2': [1496, 1740, 1878, 3620, 3655], '(23Faull': [1497], 'R.J.': [1498], 'Russ': [1499], 'Transplantation.': [1501], '48:': [1503], '226-230Crossref': [1504], '(148)': [1507], 'Faull': [1515], '(St.': [1516], 'George': [1517], 'Hospital,': [1518], 'Kogarah,': [1519], 'Australia).': [1520], 'anti-αvβ3': [1522], 'LM': [1524, 1865], '609': [1525, 1866], '(24Cheresh': [1526], '84:': [1536], '6471-6475Crossref': [1537], '(420)': [1540], 'Cheresh': [1549], '(Scripps': [1550], 'Research': [1551], 'Institute,': [1552], 'La': [1553], 'Jolla,': [1554], 'CA).': [1555, 1577, 1599, 1907, 1948], 'mAb1980,': [1556, 1868], 'mAb1969,': [1557, 1874], 'mAb1965': [1559], 'mAbs': [1560, 1864, 1877], 'subunits': [1565, 3702], 'αv,': [1566], 'α5,': [1567], 'β1,': [1569], 'respectively,': [1570, 1609], 'obtained': [1572, 1594, 1633], 'Chemicon': [1574], '(Temecula,': [1576], 'MAb': [1578], 'KB90': [1579], 'subunit': [1583, 1592], 'αX': [1584, 3720], '(CD11c,': [1585], 'P150,95)': [1586], 'MHM23': [1588], 'β2': [1590, 1605, 4085], 'Dako': [1596], 'Corp.': [1597], '(Carpinteria,': [1598], 'Antibodies': [1600], 'TS1/18': [1601, 3062, 4088, 4511], 'TS1/22': [1603], 'αL': [1607, 3689], 'subunits,': [1608], 'American': [1613], 'Type': [1614], 'Culture': [1615, 2448], 'Collection': [1616], '(ATCC,': [1617], 'Rockville,': [1618], 'MD).': [1619], 'lymphoblastoid': [1621], 'human': [1628, 1954, 4110], 'kidney': [1629], 'fibroblast': [1630], 'origin': [1631], 'ATCC.': [1635], 'grown': [1638, 2624, 3608, 4241], 'RPMI': [1640], '1640': [1641], '(BioWhittaker,': [1642], 'Walkersville,': [1643], 'MD)': [1644], '7.5%': [1646], 'FCS': [1647, 1664, 1888, 2837, 4219], '1.0': [1649, 1666, 2368], 'mm': [1650, 1667, 1820, 1823, 1826, 2267, 2369], 'glutamine.': [1651, 1668], 'maintained': [1655, 2832], "Eagle's": [1659, 2363], 'medium/F-12': [1660], '(BioWhittaker)': [1661], '10%': [1663, 4218, 4245], 'For': [1669, 2194], 'transfection,': [1670], 'washed': [1674, 1789, 2637, 2853, 2966], 'plated': [1676], '60-mm': [1678], 'plastic': [1679], 'Petri': [1680], 'dishes': [1681], 'without': [1684, 1804, 2836], 'FCS.': [1685, 4246], 'Cells': [1686, 1731, 1835, 1881, 1908, 2851, 2954], 'stably': [1688], 'using': [1690, 1932, 1939, 2008, 2079, 2117, 2261, 2359, 2519, 2594, 2675, 2726, 3050, 3197, 3563, 3587, 3616, 3653, 3923], 'calcium-phosphate': [1692], '10–20': [1695], 'μg': [1696], 'plasmid': [1699], 'DNA': [1700, 2408, 2581, 2586, 2604, 2980, 4121, 4181], 'isolated': [1701, 1746, 1769, 1779, 2043, 2285, 2956, 3047, 4324], 'E.': [1703], 'coli': [1704], 'pCDM8': [1707], '(25Zhang': [1711], 'L.': [1712, 2497, 3770], '18211-18216Abstract': [1720], '(85)': [1728], 'expressing': [1732], 'incubation': [1737, 2958, 4212], 'FITC-conjugated': [1742, 1897], 'anti-mouse': [1743, 1899], 'IgG': [1744, 1900, 4504], 'sorter': [1751], '(FACS).': [1752], 'Levels': [1753], 'routinely': [1758], 'monitored': [1759], 'FACS': [1761, 3612], 'analysis.': [1762], 'Control': [1763], 'flasks': [1772], 'brief': [1774], 'trypsin': [1775], 'treatment.': [1776], 'centrifugation.': [1784], 'Each': [1785, 2246], 'type': [1787], 'twice': [1790, 2854, 2967], 'phosphate-buffered': [1793, 2279, 2639, 2651, 2969], 'saline,': [1794, 2640, 2652, 2970], 'pH': [1795, 1828, 2269, 2317, 2641, 2653, 2728, 2753, 2971], '7.4,': [1796, 1829, 2270, 2318, 2642, 2754], 'once': [1798, 3004], "Hanks'": [1800, 1814, 3027, 3034], 'balanced': [1801, 1815, 3028, 3035], 'salt': [1802, 1816, 3029, 3036], 'solution': [1803, 1817, 2313, 3011, 3030, 3037], 'divalent': [1805], 'cations': [1806], 'then': [1807, 1918, 2636], 'resuspended': [1808, 1839, 1890, 1921, 2789, 3023], 'staining': [1811, 1892, 1926, 2778], '2.0': [1819, 1822], 'CaCl2,': [1821], 'MgCl2,': [1824], '25': [1825, 3060, 4071], 'HEPES,': [1827], '0.1%': [1831, 3039], 'albumin.': [1834, 3042], 'counted': [1837, 2858], '106': [1841, 3088], 'cells/ml,': [1842], '0.1-ml': [1844], 'aliquots': [1845, 2795], 'incubated': [1847, 1910, 2224, 3115, 4194], '4': [1849, 1915, 2634, 2896, 2997], '°C': [1850, 1916, 2191, 2227, 2928], '30': [1852, 1912, 2867, 3072, 3117], 'min': [1853, 1913, 2868, 3118, 3143], '5.0': [1855], 'μg/ml': [1856, 1896, 2230, 2373, 3061, 4072, 4386], 'mouse': [1858, 4503], 'IgG,': [1859], 'anti-αM': [1860], 'OKM1,': [1862], 'anti-αVβ3': [1863], 'or': [1867, 1875, 1879, 2659, 2828, 2872, 3066, 3109, 3737, 4157, 4507], 'anti-αX': [1869], 'KB90,': [1871], 'anti-α5': [1872], '84H10.': [1880], 'centrifuged': [1883, 1919, 3021], 'cushion': [1886], '50': [1895, 2266, 2315], 'goat': [1898], '(Zymed': [1902], 'Laboratories,': [1903], 'South': [1904], 'San': [1905, 1946, 2398], 'Francisco,': [1906], '0.5': [1923], 'ml': [1924, 2880, 2987, 3083], 'medium.': [1927], 'Cell-bound': [1928], 'FACScan,': [1934], 'analysis': [1936, 3613], 'performed': [1938], 'LYSIS': [1941], 'II': [1942], 'program': [1943], '(Becton': [1944, 2917], 'Dickinson,': [1945, 2918], 'Jose,': [1947], 'fresh': [1953], 'cryoethanol': [1957], 'precipitation': [1958], '(26Budzynski': [1959, 2201], 'A.Z.': [1960, 2202], 'Marder': [1961, 2203], '1974;': [1968, 2210], '249:': [1969, 2211], '2294-2302Abstract': [1970, 2212], 'Scholar,27Doolittle': [1976], 'Schubert': [1978], 'Schwartz': [1980], 'Arch.': [1982], 'Biophys.': [1984, 2499], '1967;': [1985], '118:': [1986], '456-467Crossref': [1987], '(179)': [1990], 'Using': [1993], 'electrophoretic': [1994], 'conditions': [1995], 'allow': [1997], 'separation': [1999], 'monomer': [2004], 'subsequent': [2006], 'visualization': [2007], 'Coomassie': [2009], 'violet': [2010], 'R-250': [2011], 'material': [2044, 2739], 'estimated': [2046], 'comprise': [2048], 'greater': [2049, 2095, 2771], 'than': [2050, 2096, 2772], '95%': [2051], 'fibrinogen.': [2052], 'Preparations': [2053], 'analyzed': [2058], 'presence': [2061], 'free': [2063, 3124], 'fibrinopeptides': [2064, 2086, 2104], 'elution': [2069, 2263], 'Sep-Pak': [2072], 'C18': [2073], 'high': [2074, 3578], 'pressure': [2075, 3579], 'liquid': [2076, 3580], 'chromatography': [2077, 2252, 2300], 'column': [2078, 2255, 2303], 'standard': [2080], 'preparations': [2081, 2292, 2296], 'each': [2083, 2943], '(Sigma).': [2087], 'At': [2088], 'concentrations': [2090, 2353], '50-fold': [2094], 'those': [2097], 'these': [2100, 2295, 3595, 3743, 4407], 'experiments,': [2101], 'amounts': [2102, 3075, 4153, 4289], 'below': [2109, 3835], 'detectable': [2110, 3836], 'levels.': [2111], 'radiolabeled': [2114], '125I-Na': [2116], 'IODO-BEADS': [2118], '(Pierce)': [2119], '(28Marguerie': [2120], 'G.A.': [2121], 'Edgington': [2122, 3752], 'T.S.': [2123, 3753], '1980;': [2129], '255:': [2130], '154-161Abstract': [2131], "29D'Souza": [2138], 'Haas': [2140], 'Piotrowicz': [2142], 'R.S.': [2143], 'V.': [2145], 'McGrath': [2146], 'Soule': [2148], 'H.R.': [2149], 'Cierniewski': [2150], 'C.S.': [2151], 'J.W.': [2155], '79:': [2158], '659-667Abstract': [2159], '(204)': [2165], 'extensively': [2169, 2277, 2330], 'dialyzed': [2170, 2276, 2329], '0.3m': [2172], 'NaCl.': [2173, 2322], 'specific': [2175, 2520, 3930, 4078, 4146], '125I-labeled': [2178, 3077, 3935, 4048, 4079], '0.45–0.52': [2181], 'mCi/mg.': [2182], 'Radiolabeled': [2183], 'aliquoted': [2186, 2907], 'stored': [2188, 2380, 2797, 2925], '−80': [2190], 'until': [2192], 'use.': [2193], 'preparation': [2196, 2806], 'plasmin-digested': [2198], '(5.0': [2221], 'mg/ml)': [2222], '37': [2226, 2927], '8.3': [2229], 'plasmin': [2231, 2240, 2340], '1': [2233, 2357, 2793, 3630, 3942], 'h': [2234, 2243, 2840, 2995, 4187, 4225, 4256], '(fragment': [2235, 2244], 'X)': [2236], '0.1': [2238, 2986, 3082], 'mg/ml': [2239, 2358], '2': [2242, 2994, 4168, 4377], 'D100).': [2245], 'ion-exchange': [2251], 'DEAE-cellulose': [2257], '(Pharmacia,': [2258, 2307], 'Uppsala,': [2259, 2308], 'Sweden)': [2260, 2309], 'buffer': [2264, 2749], 'Tris/HCl,': [2268], '0.4': [2272], 'm': [2273, 2321], 'NaCl': [2274], 'saline.': [2280], 'by-product': [2288], 'subjecting': [2294], 'size': [2298], 'exclusion': [2299], 'Sephacryl': [2305], 'S200': [2306], 'equilibrated': [2310], 'mmTris/HCl,': [2316], '0.15': [2320], 'Fractions': [2323], 'distilled': [2332], 'water': [2333], 'lyophilized.': [2335], 'weights': [2338], 'digestion': [2341], 'verified': [2346, 4264], 'electrophoresis': [2348], 'SDS': [2350, 2734, 2758, 2780, 3010], 'gels.': [2351], 'Protein': [2352], 'adjusted': [2355], 'penicillin,': [2366], 'streptomycin,': [2367], 'glutamine,': [2370], '5': [2372], 'transferrin': [2374, 4158], '(IMDM)': [2375], '(Life': [2376, 2630], 'Technologies,': [2377, 2631], 'Inc.),': [2378], '−20': [2382, 2799], '°C.': [2383, 2800, 2998, 3121], 'full-length': [2385], 'five-domain': [2386], 'ligated': [2391, 2588], 'into': [2392, 2589, 2908, 2978, 4137], 'viral': [2394], 'vector': [2395, 2592, 2603], 'PVL1392': [2396], '(Invitrogen,': [2397], 'Diego,': [2399], 'CA)': [2400], 'allowed': [2402], 'recombine': [2404], 'baculoviral': [2406], 'genomic': [2407], 'Scholar,30Summers': [2434], 'M.D.': [2435, 2474], 'G.E.': [2437, 2462], 'Manual': [2439], 'Methods': [2441], 'Baculovirus': [2443], 'Vectors': [2444], 'Insect': [2446], 'Procedures,': [2449], 'Bulletin': [2450], '1555.': [2451], 'Texas': [2452], 'Agricultural': [2453], 'Experiment': [2454], 'Station,': [2455, 2457], 'College': [2456], 'TX1987:': [2458], '1-57Google': [2459], '31Smith': [2461], 'Ju': [2463], 'G.': [2464], 'Ericson': [2465], 'B.L.': [2466], 'Moschera': [2467], 'Lahm': [2469], 'Chizzonite': [2471], 'Summers': [2473], '1985;': [2482, 3181], '8404-8408Crossref': [2484], '(220)': [2487], '32Cobb': [2490], 'R.R.': [2491], 'Dubins': [2492], 'J.S.': [2493], 'Warner': [2494], 'Molony': [2496], 'Res.': [2500, 3180], 'Commun.': [2501], '185:': [2503], '1022-1033Crossref': [2504], '(10)': [2507], 'Truncated': [2510], 'generated': [2514], 'polymerase': [2516, 2578], 'reaction': [2518], 'primers': [2521], 'annealed': [2523], 'extreme': [2526], '5′': [2527], '3′': [2535, 2544], 'encoding': [2538, 2565], 'second': [2540], 'IgG-like': [2541], 'domain.': [2542], 'reverse': [2545], 'primer': [2546], 'contained': [2547], 'appropriate': [2548, 2834], 'stop': [2552], 'codon': [2553], 'NotI': [2556, 2597], 'restriction': [2557, 2598], 'enzyme': [2558], 'site': [2559], 'unique': [2562], 'nucleotide': [2574], 'reaction-amplified': [2580], 'confirmed,': [2583], 'baculovirus': [2591], 'pBlueBacIII': [2593], 'XbaI': [2595], 'sites.': [2599], 'Recombinant': [2600], 'virus': [2601], 'repeated': [2608], 'plaque': [2609], 'purification': [2610], 'infection': [2614], 'Spodoptera': [2616], 'frugiperda': [2617], '(Sf9)': [2618], 'insect': [2619, 2627], 'Sf9': [2621, 2715], "Grace's": [2626], 'media': [2629], 'Inc.)': [2632], 'days,': [2635], 'lysed': [2644], '1%': [2646], '(w/v)': [2647, 2757, 3009], 'octyl': [2648], 'glucoside': [2649], '7.4.': [2654, 2972], 'Expression': [2655], 'intact': [2657], '(D1D2ICAM-1)': [2666], 'enzyme-linked': [2670], 'immunosorbent': [2671], 'assay': [2672], 'immunoblotting': [2674], 'ICAM-1-specific': [2676], 'previously': [2680, 3856], 'Full-length': [2707], 'D1D2': [2710, 2768, 2786], 'lysates': [2717], 'Rotofor': [2720], 'preparative': [2721], 'isoelectric': [2722], 'focusing': [2723], 'apparatus': [2724], '(Bio-Rad)': [2725], 'gradient': [2729], '6–8.': [2731], 'Portions': [2732], 'gels': [2735], 'similar,': [2737], 'unstained': [2738], 'excised,': [2741], 'extracted': [2746], '0.2': [2751, 2879, 3095], 'mTris/HCl,': [2752], '2%': [2756, 3008], 'precipitated': [2760, 2982], '80%': [2762, 4233], '(v/v)': [2763, 2990], 'acetone.': [2764], 'purity': [2766], '90%,': [2773], 'judged': [2775], 'silver': [2777], 'gels,': [2781], 'portions': [2783], 'IMDM': [2791, 2856, 2894], 'μm': [2794], 'In': [2801], 'assays,': [2803], 'support': [2810], '51Cr-labeled': [2814], 'peripheral': [2815], 'lymphocytes': [2817, 3840], 'could': [2820, 3723, 3960], 'blocked': [2822, 3963], 'anti-β2antibody': [2825], 'MHM23.': [2826], '24': [2839, 4224], 'prior': [2841], 'commencement': [2843], 'experiment,': [2846], 'achieve': [2848], 'quiescence.': [2850], 'hemocytometer.': [2861], 'Some': [2862, 3097], 'preincubated': [2865, 3058], 'Aliquots': [2877], '(4': [2883], '×': [2884, 3087, 3139, 3955], '105cells/ml)': [2885], 'mixed': [2887, 3080, 3166], '0.2-ml': [2889], 'solutions': [2891], 'diluted': [2892], 'μl': [2897], '(1.0': [2900], 'μCi/μl).': [2901], 'suspensions': [2903, 3056, 3113], '(0.1': [2904, 3157], 'ml)': [2905, 3152, 3158], 'four': [2909], 'replicate': [2910], 'wells': [2911], '96-well': [2914, 2949], 'flat-bottomed': [2915], 'plate': [2916, 2950], 'Franklin': [2919], 'Lakes,': [2920], 'NJ),': [2921], 'plates': [2923], '5%': [2930], 'CO2': [2931], '4–24': [2933], 'To': [2935], 'measure': [2936], 'uptake': [2937], '[3H]thymidine,': [2939], 'contents': [2941], 'transferred': [2946], 'v-shaped': [2952], 'wells.': [2953], 'centrifugation': [2961, 3136], '(200': [2962], '×g/10': [2963], 'min)': [2964], '[3H]Thymidine': [2973], 'had': [2975, 4283, 4514], 'incorporated': [2977], 'addition': [2984, 4392], '20%': [2989], 'trichloroacetic': [2991], 'Trichloroacetic': [2999], 'pellets': [3001], 'rinsed': [3003], 'resolubilized': [3006], 'assayed': [3013, 3196], 'radioactivity': [3015, 3125, 3129], 'β-counter.': [3018], 'three': [3024], 'times': [3025], 'finally': [3032], 'number': [3044], 'ascertained': [3049], 'hemocytometer,': [3052], 'some': [3054], 'anti-β2': [3063, 4508], 'min.': [3073], 'Increasing': [3074], '(5': [3086], 'cells/ml)': [3089], 'final': [3092], 'volume': [3093], 'ml.': [3096], 'mixtures': [3099], '10–50-fold': [3103], 'excess': [3104, 3966], 'either': [3106], 'unlabeled': [3107, 3968], 'transferrin.': [3110, 3976], 'All': [3111], '22': [3120], 'Following': [3122], 'incubation,': [3123], 'separated': [3127], 'bound': [3130, 4062], '11,300': [3138], 'g': [3140], '2.5': [3142], 'upper': [3146], 'phase': [3147, 3156], '8%': [3149], 'sucrose': [3150], '(0.2': [3151], 'lower': [3155], 'dibutyl': [3160], 'phthalate': [3161, 3164], 'dimethyl': [3163], '(Aldrich)': [3165], 'proportion': [3169], '10:1.05': [3171], '(33Levesque': [3172], 'Exp.': [3178], '156:': [3182], '558-562Crossref': [3183], '(9)': [3186], 'Radioactivity': [3189], 'associated': [3190, 3946], 'pellet': [3194], 'γ-counter.': [3199], 'Peptides': [3200, 3555, 3574], 'synthesized': [3213], 'Fmoc': [3216], '(N-(9-fluorenyl)methoxycarbonyl)': [3217], 'Applied': [3221], 'Biosystems': [3222], 'ABI-66': [3223], 'instrument.': [3224], 'Specific': [3225], '9van': [3243], '10Doolittle': [3261], '11Bini': [3274], "14D'Souza": [3340], '15Hicks': [3366], '16Lévesque': [3383], '17Zhou': [3404], '18Shainoff': [3425], '19Vuento': [3455], '20Simmons': [3469], 'KVILPRGGSVLVTCS,': [3537], '(130–139)': [3539], 'REPAVGEPAE,': [3540], 'Aα(571–576)': [3542], 'GRGDSP,': [3543], 'γ(117–133)': [3545, 3548], 'NNQKIVNLKEKVAQLEA,': [3546], 'scrambled': [3549], 'ALENAEVQNLVKKIQKN,': [3550], 'γ(124–133)': [3553], 'LKEKVAQLEA.': [3554], 'resin': [3560], 'deprotected': [3562], 'crystalline': [3564], 'phenol': [3565], 'thioanisole': [3567], 'instruction': [3572], 'manual.': [3573], 'chromatography.': [3581], 'studies': [3583], 'carried': [3585], 'out': [3586], 'line': [3593], 'demonstrate': [3597], 'constitutive': [3599, 3623, 3686], 'stable': [3601, 3625], 'readily': [3607], 'suspension': [3610], 'culture.': [3611], 'revealed': [3621], '(Fig.': [3629, 3941, 4139, 4167], 'A,': [3631], 'panel': [3632], 'a)': [3633], 'represented': [3635, 4203], 'approximately': [3636, 4066, 4204, 4232, 4320], '75%': [3637], 'found': [3643], 'upon': [3647], 'tumor': [3650], 'necrosis': [3651], 'factor-α': [3652], '(panel': [3690, 3711, 3714, 3717, 3721], 'd);': [3691], 'α': [3701], 'including': [3709], 'αV': [3710], 'b),': [3712], 'α5': [3713], 'c),': [3715], 'αM': [3716], 'e),': [3718], 'f)': [3722], 'detected,': [3726], 'suggesting': [3727], 'negligible': [3728], 'heterodimers': [3733], 'αMβ2,': [3734], 'αXβ2,': [3735], 'αVβ3,': [3736], 'α5β1on': [3738], 'As': [3740, 4349], 'Fg-binding': [3744], '(34Altieri': [3746], 'Bader': [3748], 'Mannucci': [3750], '107:': [3758], '1893-1900Crossref': [3759], '(304)': [3762], '35Loike': [3765], 'J.D.': [3766], 'Sodeik': [3767], 'Cao': [3769], 'Leucona': [3771], 'Weitz': [3773], 'J.I.': [3774], 'Detmers': [3775], 'Wright': [3777], 'Silverstein': [3779], 'S.C.': [3780], '88:': [3789], '1044-1048Crossref': [3790], '(228)': [3793], '36Cheresh': [3796], 'Spiro': [3798], 'R.C.': [3799], '262:': [3804], '17703-17711Abstract': [3805], '37Suehiro': [3812], 'Gailit': [3814], '1997;': [3821], '272:': [3822], '5360-5366Abstract': [3823], '(149)': [3831], 'levels,': [3837], 'suitable': [3843], 'means': [3844], 'exclusively': [3846], 'studying': [3847], 'interactions.': [3849], 'others': [3859], 'we': [3882, 4365], 'recently': [3884], 'ICAM-1-dependent': [3892], 'finding': [3920], 'soluble': [3925, 4103], 'assay.': [3928], 'saturable': [3932], 'B).': [3943, 4142, 4169], '125I-Labeled': [3944], 'K': [3951, 3978, 3985], 'd': [3952, 3979, 3986], '3': [3954], '10−7m': [3956], 'competitively': [3962], 'equivalent': [3973, 4152], 'amount': [3974], 'value': [3980], 'comparable': [3982], 'other': [3984], 'values': [3987], 'ICAM-1/Fg': [3990], 'Analysis': [4045], 'data': [4051], 'suggested': [4052], 'single': [4054], 'class': [4055], 'sites': [4058], 'total': [4064], '40,000': [4067], 'molecules/cell.': [4068], 'Inclusion': [4069, 4500], 'completely': [4076], 'Raji,': [4083, 4120], 'while': [4084], 'failed': [4089], 'block125I-labeled': [4091], 'Experiments': [4096], 'designed': [4098], 'investigate': [4100], 'When': [4108], 'included': [4113], 'serum-depleted': [4119], 'synthesis': [4122, 4182], 'stimulated': [4124], 'time-': [4127], 'dose-dependent': [4129], 'manner': [4130], 'measured': [4132], 'macromolecules': [4138], '2,A': [4140], 'did': [4159], 'any': [4162], 'Medium': [4170], 'nm': [4173], 'consistently': [4175], '2–3-fold': [4178], 'compared': [4189], '[3H]thymidine-containing': [4196], 'alone': [4198], '(n=': [4199], '15).': [4200], 'stimulation': [4202, 4209, 4228], '120%': [4205], 'maximal': [4208], 'After': [4223], '2-fold': [4248], 'numbers': [4253], 'counting': [4268], 'measurement': [4271], 'intracellular': [4275], 'enzymes': [4276], '(data': [4277], 'shown),': [4279], 'confirming': [4280, 4307], 'Similar': [4288], 'fibrin-free': [4291], 'identical': [4298], 'presented': [4301], 'Fig.': [4303, 4376], '2,': [4304], 'andB,': [4306], 'component.': [4313], 'putative': [4315], '92': [4321], 'kDa': [4322], 'conclusively': [4329], 'identified': [4330], '(38Levesque': [4331], '265:': [4341], '328-333Abstract': [4342], 'known': [4354], 'interact,': [4356], 'surfaces,': [4364], 'whether': [4367], 'C': [4378], 'shows': [4379], 'preincubation': [4381], '20': [4385], 'before': [4390], 'nmFg': [4395], 'resulted': [4396], '91%': [4399], 'inhibition': [4400], 'Fg-induced': [4402], 'αLβ2-dependent': [4417], 'Scholar,21Makgoba': [4433], 'located': [4464], '(22Berendt': [4472], 'normal': [4502], '(not': [4505], 'shown)': [4506], '(20': [4512], 'μg/ml)': [4513], 'no': [4515], 'Fg-': [4519]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2068428035', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2023, 'cited_by_count': 1}, {'year': 2021, 'cited_by_count': 1}, {'year': 2018, 'cited_by_count': 1}, {'year': 2017, 'cited_by_count': 1}, {'year': 2016, 'cited_by_count': 1}, {'year': 2015, 'cited_by_count': 2}, {'year': 2014, 'cited_by_count': 2}, {'year': 2013, 'cited_by_count': 3}, {'year': 2012, 'cited_by_count': 1}], 'updated_date': '2024-12-11T07:27:16.905969', 'created_date': '2016-06-24'}
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