Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2068334663', 'doi': 'https://doi.org/10.1097/icu.0b013e32835f8ec0', 'title': 'Ocular and systemic safety of bevacizumab and ranibizumab in patients with neovascular age-related macular degeneration', 'display_name': 'Ocular and systemic safety of bevacizumab and ranibizumab in patients with neovascular age-related macular degeneration', 'publication_year': 2013, 'publication_date': '2013-03-22', 'ids': {'openalex': 'https://openalex.org/W2068334663', 'doi': 'https://doi.org/10.1097/icu.0b013e32835f8ec0', 'mag': '2068334663', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/23518613'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1097/icu.0b013e32835f8ec0', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S145244763', 'display_name': 'Current Opinion in Ophthalmology', 'issn_l': '1040-8738', 'issn': ['1040-8738', '1080-8132', '1531-7021'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315671', 'host_organization_name': 'Lippincott Williams & Wilkins', 'host_organization_lineage': ['https://openalex.org/P4310315671', 'https://openalex.org/P4310318547'], 'host_organization_lineage_names': ['Lippincott Williams & Wilkins', 'Wolters Kluwer'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'review', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5040478720', 'display_name': 'Davin Johnson', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I204722609', 'display_name': "Queen's University", 'ror': 'https://ror.org/02y72wh86', 'country_code': 'CA', 'type': 'education', 'lineage': ['https://openalex.org/I204722609']}], 'countries': ['CA'], 'is_corresponding': False, 'raw_author_name': 'Davin Johnson', 'raw_affiliation_strings': ["Department of Ophthalmology, Queen's University Kingston, Ontario, Canada"], 'affiliations': [{'raw_affiliation_string': "Department of Ophthalmology, Queen's University Kingston, Ontario, Canada", 'institution_ids': ['https://openalex.org/I204722609']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5041247166', 'display_name': 'Sanjay Sharma', 'orcid': 'https://orcid.org/0000-0003-3951-7560'}, 'institutions': [{'id': 'https://openalex.org/I204722609', 'display_name': "Queen's University", 'ror': 'https://ror.org/02y72wh86', 'country_code': 'CA', 'type': 'education', 'lineage': ['https://openalex.org/I204722609']}, {'id': 'https://openalex.org/I2801322873', 'display_name': 'Hotel Dieu Hospital', 'ror': 'https://ror.org/01s7w1z60', 'country_code': 'CA', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2801322873']}], 'countries': ['CA'], 'is_corresponding': True, 'raw_author_name': 'Sanjay Sharma', 'raw_affiliation_strings': ["Department of Ophthalmology, Queen's University Kingston, Ontario, Canada", 'e-mail: [email\xa0protected]', 'to Sanjay Sharma, MD, MSc, MBA, FRCSC, Professor, Departments of Ophthalmology and Epidemiology, Hotel Dieu Hospital, 166 Brock St., Kingston, Ontario K7L5G2, Canada. Tel: +1 613 544 3400'], 'affiliations': [{'raw_affiliation_string': "Department of Ophthalmology, Queen's University Kingston, Ontario, Canada", 'institution_ids': ['https://openalex.org/I204722609']}, {'raw_affiliation_string': 'to Sanjay Sharma, MD, MSc, MBA, FRCSC, Professor, Departments of Ophthalmology and Epidemiology, Hotel Dieu Hospital, 166 Brock St., Kingston, Ontario K7L5G2, Canada. Tel: +1 613 544 3400', 'institution_ids': ['https://openalex.org/I2801322873']}, {'raw_affiliation_string': 'e-mail: [email\xa0protected]', 'institution_ids': []}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 2, 'corresponding_author_ids': ['https://openalex.org/A5041247166'], 'corresponding_institution_ids': ['https://openalex.org/I204722609', 'https://openalex.org/I2801322873'], 'apc_list': None, 'apc_paid': None, 'fwci': 0.875, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 29, 'citation_normalized_percentile': {'value': 0.569182, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 92, 'max': 93}, 'biblio': {'volume': '24', 'issue': '3', 'first_page': '205', 'last_page': '212'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10170', 'display_name': 'Age-Related Macular Degeneration Research', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2731', 'display_name': 'Ophthalmology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10170', 'display_name': 'Age-Related Macular Degeneration Research', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2731', 'display_name': 'Ophthalmology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11194', 'display_name': 'Epidemiology and Management of Ocular Inflammatory Diseases', 'score': 0.9991, 'subfield': {'id': 'https://openalex.org/subfields/2731', 'display_name': 'Ophthalmology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11438', 'display_name': 'Detection and Management of Retinal Diseases', 'score': 0.9972, 'subfield': {'id': 'https://openalex.org/subfields/2741', 'display_name': 'Radiology, Nuclear Medicine and Imaging'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/intravitreal-injection', 'display_name': 'Intravitreal Injection', 'score': 0.530605}], 'concepts': [{'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.9708597}, {'id': 'https://openalex.org/C2781100027', 'wikidata': 'https://www.wikidata.org/wiki/Q414270', 'display_name': 'Ranibizumab', 'level': 4, 'score': 0.97021776}, {'id': 'https://openalex.org/C2777802072', 'wikidata': 'https://www.wikidata.org/wiki/Q413299', 'display_name': 'Bevacizumab', 'level': 3, 'score': 0.9435369}, {'id': 'https://openalex.org/C2776403814', 'wikidata': 'https://www.wikidata.org/wiki/Q27429789', 'display_name': 'Macular degeneration', 'level': 2, 'score': 0.82539505}, {'id': 'https://openalex.org/C197934379', 'wikidata': 'https://www.wikidata.org/wiki/Q2047938', 'display_name': 'Adverse effect', 'level': 2, 'score': 0.68461907}, {'id': 'https://openalex.org/C118487528', 'wikidata': 'https://www.wikidata.org/wiki/Q161437', 'display_name': 'Ophthalmology', 'level': 1, 'score': 0.5846167}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.21917766}, {'id': 'https://openalex.org/C2776694085', 'wikidata': 'https://www.wikidata.org/wiki/Q974135', 'display_name': 'Chemotherapy', 'level': 2, 'score': 0.17093316}], 'mesh': [{'descriptor_ui': 'D061067', 'descriptor_name': 'Antibodies, Monoclonal, Humanized', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': True}, {'descriptor_ui': 'D057135', 'descriptor_name': 'Wet Macular Degeneration', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': True}, {'descriptor_ui': 'D020533', 'descriptor_name': 'Angiogenesis Inhibitors', 'qualifier_ui': 'Q000009', 'qualifier_name': 'adverse effects', 'is_major_topic': False}, {'descriptor_ui': 'D020533', 'descriptor_name': 'Angiogenesis Inhibitors', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': False}, {'descriptor_ui': 'D020533', 'descriptor_name': 'Angiogenesis Inhibitors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D061067', 'descriptor_name': 'Antibodies, Monoclonal, Humanized', 'qualifier_ui': 'Q000009', 'qualifier_name': 'adverse effects', 'is_major_topic': False}, {'descriptor_ui': 'D061067', 'descriptor_name': 'Antibodies, Monoclonal, Humanized', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000068258', 'descriptor_name': 'Bevacizumab', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D058449', 'descriptor_name': 'Intravitreal Injections', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D056687', 'descriptor_name': 'Off-Label Use', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000069579', 'descriptor_name': 'Ranibizumab', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D042461', 'descriptor_name': 'Vascular Endothelial Growth Factor A', 'qualifier_ui': 'Q000037', 'qualifier_name': 'antagonists & inhibitors', 'is_major_topic': False}, {'descriptor_ui': 'D042461', 'descriptor_name': 'Vascular Endothelial Growth Factor A', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014792', 'descriptor_name': 'Visual Acuity', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}, {'descriptor_ui': 'D014792', 'descriptor_name': 'Visual Acuity', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D057135', 'descriptor_name': 'Wet Macular Degeneration', 'qualifier_ui': 'Q000503', 'qualifier_name': 'physiopathology', 'is_major_topic': False}, {'descriptor_ui': 'D057135', 'descriptor_name': 'Wet Macular Degeneration', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1097/icu.0b013e32835f8ec0', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S145244763', 'display_name': 'Current Opinion in Ophthalmology', 'issn_l': '1040-8738', 'issn': ['1040-8738', '1080-8132', '1531-7021'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315671', 'host_organization_name': 'Lippincott Williams & Wilkins', 'host_organization_lineage': ['https://openalex.org/P4310315671', 'https://openalex.org/P4310318547'], 'host_organization_lineage_names': ['Lippincott Williams & Wilkins', 'Wolters Kluwer'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/23518613', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'score': 0.84, 'id': 'https://metadata.un.org/sdg/3', 'display_name': 'Good health and well-being'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 111, 'referenced_works': ['https://openalex.org/W115097612', 'https://openalex.org/W1481978003', 'https://openalex.org/W1493343577', 'https://openalex.org/W1500728559', 'https://openalex.org/W1516883653', 'https://openalex.org/W1965415561', 'https://openalex.org/W1966486839', 'https://openalex.org/W1974962627', 'https://openalex.org/W1975986695', 'https://openalex.org/W1982733715', 'https://openalex.org/W1983763042', 'https://openalex.org/W1984413085', 'https://openalex.org/W1984850323', 'https://openalex.org/W1986457383', 'https://openalex.org/W1989312280', 'https://openalex.org/W1990136344', 'https://openalex.org/W1992267606', 'https://openalex.org/W1993747607', 'https://openalex.org/W1995044506', 'https://openalex.org/W1995708259', 'https://openalex.org/W1997244967', 'https://openalex.org/W2000836065', 'https://openalex.org/W2003601553', 'https://openalex.org/W2003869308', 'https://openalex.org/W2004033327', 'https://openalex.org/W2004237626', 'https://openalex.org/W2005385371', 'https://openalex.org/W2005448076', 'https://openalex.org/W2007023975', 'https://openalex.org/W2011393181', 'https://openalex.org/W2013705308', 'https://openalex.org/W2013865180', 'https://openalex.org/W2015344488', 'https://openalex.org/W2015805580', 'https://openalex.org/W2018875379', 'https://openalex.org/W2020050260', 'https://openalex.org/W2020158860', 'https://openalex.org/W2020732840', 'https://openalex.org/W2021415488', 'https://openalex.org/W2024416781', 'https://openalex.org/W2027875367', 'https://openalex.org/W2031205148', 'https://openalex.org/W2031737722', 'https://openalex.org/W2034029819', 'https://openalex.org/W2035786085', 'https://openalex.org/W2036832061', 'https://openalex.org/W2036940508', 'https://openalex.org/W2037978728', 'https://openalex.org/W2040674866', 'https://openalex.org/W2043863730', 'https://openalex.org/W2043885997', 'https://openalex.org/W2044157838', 'https://openalex.org/W2047424583', 'https://openalex.org/W2048049691', 'https://openalex.org/W2052826267', 'https://openalex.org/W2052892208', 'https://openalex.org/W2055385676', 'https://openalex.org/W2057196912', 'https://openalex.org/W2057204474', 'https://openalex.org/W2059176107', 'https://openalex.org/W2059742424', 'https://openalex.org/W2065425407', 'https://openalex.org/W2067731615', 'https://openalex.org/W2068742492', 'https://openalex.org/W2071548666', 'https://openalex.org/W2075984382', 'https://openalex.org/W2078028176', 'https://openalex.org/W2080886828', 'https://openalex.org/W2081275070', 'https://openalex.org/W2085712747', 'https://openalex.org/W2085945127', 'https://openalex.org/W2089509133', 'https://openalex.org/W2089838877', 'https://openalex.org/W2090387132', 'https://openalex.org/W2090779239', 'https://openalex.org/W2095251825', 'https://openalex.org/W2095310587', 'https://openalex.org/W2102012604', 'https://openalex.org/W2102548918', 'https://openalex.org/W2107923114', 'https://openalex.org/W2115952198', 'https://openalex.org/W2121785313', 'https://openalex.org/W2124415048', 'https://openalex.org/W2127486928', 'https://openalex.org/W2130646854', 'https://openalex.org/W2132441818', 'https://openalex.org/W2142693543', 'https://openalex.org/W2146660508', 'https://openalex.org/W2146673937', 'https://openalex.org/W2152447515', 'https://openalex.org/W2157204458', 'https://openalex.org/W2159361800', 'https://openalex.org/W2159562236', 'https://openalex.org/W2160726762', 'https://openalex.org/W2165066800', 'https://openalex.org/W2168865951', 'https://openalex.org/W2169580554', 'https://openalex.org/W2170468054', 'https://openalex.org/W2172216670', 'https://openalex.org/W2199292288', 'https://openalex.org/W2314031220', 'https://openalex.org/W2324273084', 'https://openalex.org/W2324968497', 'https://openalex.org/W2326275443', 'https://openalex.org/W2327207950', 'https://openalex.org/W2327541576', 'https://openalex.org/W2329117104', 'https://openalex.org/W2330906582', 'https://openalex.org/W2332234963', 'https://openalex.org/W2429981634', 'https://openalex.org/W4233722894'], 'related_works': ['https://openalex.org/W2898797637', 'https://openalex.org/W2343066505', 'https://openalex.org/W2124415048', 'https://openalex.org/W2085743381', 'https://openalex.org/W2079794035', 'https://openalex.org/W2052958850', 'https://openalex.org/W2024548441', 'https://openalex.org/W2014260690', 'https://openalex.org/W1663750035', 'https://openalex.org/W1507570872'], 'abstract_inverted_index': {'Purpose': [0], 'of': [1, 21, 56, 71, 92, 105], 'review': [2], 'This': [3], 'study': [4, 101], 'reviews': [5], 'differences': [6], 'in': [7, 18, 75], 'both': [8], 'ocular': [9], 'and': [10, 16, 63], 'systemic': [11, 72], 'safety': [12, 104], 'between': [13], 'intravitreal': [14], 'bevacizumab': [15, 34, 52, 57, 78, 93], 'ranibizumab': [17, 36], 'the': [19, 106], 'setting': [20], 'neovascular': [22], 'age-related': [23], 'macular': [24], 'degeneration.': [25], 'Recent': [26], 'findings': [27], 'Serious': [28], 'adverse': [29, 73, 87], 'events': [30, 74, 88], 'associated': [31], 'with': [32, 61, 80, 89, 98], 'either': [33], 'or': [35], 'injections': [37], 'are': [38, 94], 'generally': [39], 'rare.': [40], 'However,': [41], 'acute': [42], 'intraocular': [43], 'inflammation': [44], '(AII)': [45], 'tends': [46], 'to': [47], 'occur': [48], 'more': [49, 95], 'frequently': [50], 'following': [51], 'injection.': [53], 'Systemic': [54], 'absorption': [55], 'is': [58, 109], 'greater': [59], 'than': [60, 97], 'ranibizumab,': [62], 'many': [64], 'studies': [65], 'have': [66], 'shown': [67], 'an': [68], 'increased': [69], 'risk': [70], 'patients': [76], 'receiving': [77, 82], 'compared': [79], 'those': [81], 'ranibizumab.': [83, 99], 'Summary': [84], 'Although': [85], 'rare,': [86], 'off-label': [90], 'use': [91], 'common': [96], 'Continued': [100], 'into': [102], 'long-term': [103], 'two': [107], 'agents': [108], 'warranted.': [110]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2068334663', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2023, 'cited_by_count': 1}, {'year': 2021, 'cited_by_count': 5}, {'year': 2020, 'cited_by_count': 5}, {'year': 2019, 'cited_by_count': 2}, {'year': 2017, 'cited_by_count': 1}, {'year': 2016, 'cited_by_count': 4}, {'year': 2015, 'cited_by_count': 3}, {'year': 2014, 'cited_by_count': 3}, {'year': 2013, 'cited_by_count': 2}], 'updated_date': '2024-09-20T00:33:28.337068', 'created_date': '2016-06-24'}