Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2068294690', 'doi': 'https://doi.org/10.1111/j.1600-0854.2007.00553.x', 'title': 'Evidence for a Direct Role of the Doa4 Deubiquitinating Enzyme in Protein Sorting into the MVB Pathway', 'display_name': 'Evidence for a Direct Role of the Doa4 Deubiquitinating Enzyme in Protein Sorting into the MVB Pathway', 'publication_year': 2007, 'publication_date': '2007-03-26', 'ids': {'openalex': 'https://openalex.org/W2068294690', 'doi': 'https://doi.org/10.1111/j.1600-0854.2007.00553.x', 'mag': '2068294690', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/17376168'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1111/j.1600-0854.2007.00553.x', 'pdf_url': 'https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1600-0854.2007.00553.x', 'source': {'id': 'https://openalex.org/S174148068', 'display_name': 'Traffic', 'issn_l': '1398-9219', 'issn': ['1398-9219', '1600-0854'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'bronze', 'oa_url': 'https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1600-0854.2007.00553.x', 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5058745899', 'display_name': 'Elina Nikko', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I132053463', 'display_name': 'Université Libre de Bruxelles', 'ror': 'https://ror.org/01r9htc13', 'country_code': 'BE', 'type': 'education', 'lineage': ['https://openalex.org/I132053463']}], 'countries': ['BE'], 'is_corresponding': False, 'raw_author_name': 'Elina Nikko', 'raw_affiliation_strings': ['Laboratoire de la Physiologie Moléculaire de la Cellule, IBMM, Université Libre de Bruxelles, Rue des Professeurs Jeener et Brachet 12, B-6041 Gosselies, Belgium.'], 'affiliations': [{'raw_affiliation_string': 'Laboratoire de la Physiologie Moléculaire de la Cellule, IBMM, Université Libre de Bruxelles, Rue des Professeurs Jeener et Brachet 12, B-6041 Gosselies, Belgium.', 'institution_ids': ['https://openalex.org/I132053463']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5016391062', 'display_name': 'Bruno André', 'orcid': 'https://orcid.org/0000-0002-4531-4674'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Bruno André', 'raw_affiliation_strings': [], 'affiliations': []}], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 4220, 'currency': 'USD', 'value_usd': 4220, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 3.002, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 50, 'citation_normalized_percentile': {'value': 0.786042, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 93, 'max': 94}, 'biblio': {'volume': '8', 'issue': '5', 'first_page': '566', 'last_page': '581'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10617', 'display_name': 'Mechanisms of Intracellular Membrane Trafficking', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/1307', 'display_name': 'Cell Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10617', 'display_name': 'Mechanisms of Intracellular Membrane Trafficking', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/1307', 'display_name': 'Cell Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10587', 'display_name': 'Role of Autophagy in Disease and Health', 'score': 0.9922, 'subfield': {'id': 'https://openalex.org/subfields/2713', 'display_name': 'Epidemiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11150', 'display_name': 'Endoplasmic Reticulum Stress and Unfolded Protein Response', 'score': 0.9913, 'subfield': {'id': 'https://openalex.org/subfields/1307', 'display_name': 'Cell Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/deubiquitinating-enzyme', 'display_name': 'Deubiquitinating enzyme', 'score': 0.75476533}, {'id': 'https://openalex.org/keywords/ubiquitin-conjugating-enzyme', 'display_name': 'Ubiquitin-conjugating enzyme', 'score': 0.49714187}, {'id': 'https://openalex.org/keywords/vesicle-traffic', 'display_name': 'Vesicle Traffic', 'score': 0.436732}], 'concepts': [{'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.77574587}, {'id': 'https://openalex.org/C102658986', 'wikidata': 'https://www.wikidata.org/wiki/Q5266092', 'display_name': 'Deubiquitinating enzyme', 'level': 4, 'score': 0.75476533}, {'id': 'https://openalex.org/C25602115', 'wikidata': 'https://www.wikidata.org/wiki/Q407111', 'display_name': 'Ubiquitin', 'level': 3, 'score': 0.730738}, {'id': 'https://openalex.org/C79747257', 'wikidata': 'https://www.wikidata.org/wiki/Q189814', 'display_name': 'Endocytic cycle', 'level': 4, 'score': 0.65344054}, {'id': 'https://openalex.org/C2780216420', 'wikidata': 'https://www.wikidata.org/wiki/Q83330', 'display_name': 'Lysosome', 'level': 3, 'score': 0.61072445}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.5954981}, {'id': 'https://openalex.org/C559089031', 'wikidata': 'https://www.wikidata.org/wiki/Q658882', 'display_name': 'Protein targeting', 'level': 4, 'score': 0.581187}, {'id': 'https://openalex.org/C102747710', 'wikidata': 'https://www.wikidata.org/wiki/Q824237', 'display_name': 'Endosome', 'level': 3, 'score': 0.51562065}, {'id': 'https://openalex.org/C102568950', 'wikidata': 'https://www.wikidata.org/wiki/Q127702', 'display_name': 'Vacuole', 'level': 3, 'score': 0.5098631}, {'id': 'https://openalex.org/C2777867350', 'wikidata': 'https://www.wikidata.org/wiki/Q7908031', 'display_name': 'Vacuolar protein sorting', 'level': 4, 'score': 0.5078643}, {'id': 'https://openalex.org/C182561583', 'wikidata': 'https://www.wikidata.org/wiki/Q7876535', 'display_name': 'Ubiquitin-conjugating enzyme', 'level': 5, 'score': 0.49714187}, {'id': 'https://openalex.org/C134459356', 'wikidata': 'https://www.wikidata.org/wiki/Q4274835', 'display_name': 'Ubiquitin ligase', 'level': 4, 'score': 0.41077244}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.34536377}, {'id': 'https://openalex.org/C28005876', 'wikidata': 'https://www.wikidata.org/wiki/Q189814', 'display_name': 'Endocytosis', 'level': 3, 'score': 0.19529119}, {'id': 'https://openalex.org/C144647389', 'wikidata': 'https://www.wikidata.org/wiki/Q423042', 'display_name': 'Membrane protein', 'level': 3, 'score': 0.1898176}, {'id': 'https://openalex.org/C1491633281', 'wikidata': 'https://www.wikidata.org/wiki/Q7868', 'display_name': 'Cell', 'level': 2, 'score': 0.14443451}, {'id': 'https://openalex.org/C181199279', 'wikidata': 'https://www.wikidata.org/wiki/Q8047', 'display_name': 'Enzyme', 'level': 2, 'score': 0.1345636}, {'id': 'https://openalex.org/C190062978', 'wikidata': 'https://www.wikidata.org/wiki/Q79899', 'display_name': 'Cytoplasm', 'level': 2, 'score': 0.0974803}, {'id': 'https://openalex.org/C41625074', 'wikidata': 'https://www.wikidata.org/wiki/Q176088', 'display_name': 'Membrane', 'level': 2, 'score': 0.06625587}, {'id': 'https://openalex.org/C79879829', 'wikidata': 'https://www.wikidata.org/wiki/Q5571762', 'display_name': 'Intracellular', 'level': 2, 'score': 0.046369076}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D004705', 'descriptor_name': 'Endocytosis', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D010450', 'descriptor_name': 'Endopeptidases', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D029701', 'descriptor_name': 'Saccharomyces cerevisiae Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D014617', 'descriptor_name': 'Vacuoles', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D000251', 'descriptor_name': 'Adenosine Triphosphatases', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D000251', 'descriptor_name': 'Adenosine Triphosphatases', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D000251', 'descriptor_name': 'Adenosine Triphosphatases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D026905', 'descriptor_name': 'Amino Acid Transport Systems', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D026905', 'descriptor_name': 'Amino Acid Transport Systems', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D026905', 'descriptor_name': 'Amino Acid Transport Systems', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D002268', 'descriptor_name': 'Carboxypeptidases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002268', 'descriptor_name': 'Carboxypeptidases', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D002268', 'descriptor_name': 'Carboxypeptidases', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D002462', 'descriptor_name': 'Cell Membrane', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002462', 'descriptor_name': 'Cell Membrane', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D003600', 'descriptor_name': 'Cytosol', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D003600', 'descriptor_name': 'Cytosol', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D004705', 'descriptor_name': 'Endocytosis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004705', 'descriptor_name': 'Endocytosis', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D010450', 'descriptor_name': 'Endopeptidases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010450', 'descriptor_name': 'Endopeptidases', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D010450', 'descriptor_name': 'Endopeptidases', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}, {'descriptor_ui': 'D056827', 'descriptor_name': 'Endosomal Sorting Complexes Required for Transport', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004843', 'descriptor_name': 'Epistasis, Genetic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015151', 'descriptor_name': 'Immunoblotting', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008565', 'descriptor_name': 'Membrane Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008565', 'descriptor_name': 'Membrane Proteins', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D008565', 'descriptor_name': 'Membrane Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D008856', 'descriptor_name': 'Microscopy, Fluorescence', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008954', 'descriptor_name': 'Models, Biological', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020559', 'descriptor_name': 'Monomeric GTP-Binding Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020559', 'descriptor_name': 'Monomeric GTP-Binding Proteins', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D020559', 'descriptor_name': 'Monomeric GTP-Binding Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D009154', 'descriptor_name': 'Mutation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009687', 'descriptor_name': 'Nuclear Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009687', 'descriptor_name': 'Nuclear Proteins', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D009687', 'descriptor_name': 'Nuclear Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D021381', 'descriptor_name': 'Protein Transport', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D021381', 'descriptor_name': 'Protein Transport', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D021381', 'descriptor_name': 'Protein Transport', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}, {'descriptor_ui': 'D050765', 'descriptor_name': 'Qa-SNARE Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D050765', 'descriptor_name': 'Qa-SNARE Proteins', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D050765', 'descriptor_name': 'Qa-SNARE Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D000644', 'descriptor_name': 'Quaternary Ammonium Compounds', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000644', 'descriptor_name': 'Quaternary Ammonium Compounds', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D012441', 'descriptor_name': 'Saccharomyces cerevisiae', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D012441', 'descriptor_name': 'Saccharomyces cerevisiae', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D012441', 'descriptor_name': 'Saccharomyces cerevisiae', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012441', 'descriptor_name': 'Saccharomyces cerevisiae', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D029701', 'descriptor_name': 'Saccharomyces cerevisiae Proteins', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D029701', 'descriptor_name': 'Saccharomyces cerevisiae Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D029701', 'descriptor_name': 'Saccharomyces cerevisiae Proteins', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}, {'descriptor_ui': 'D022161', 'descriptor_name': 'Transport Vesicles', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D022161', 'descriptor_name': 'Transport Vesicles', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D025801', 'descriptor_name': 'Ubiquitin', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D025801', 'descriptor_name': 'Ubiquitin', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D025801', 'descriptor_name': 'Ubiquitin', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D043222', 'descriptor_name': 'Ubiquitin Thiolesterase', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014617', 'descriptor_name': 'Vacuoles', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D033921', 'descriptor_name': 'Vesicular Transport Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D033921', 'descriptor_name': 'Vesicular Transport Proteins', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D033921', 'descriptor_name': 'Vesicular Transport Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1111/j.1600-0854.2007.00553.x', 'pdf_url': 'https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1600-0854.2007.00553.x', 'source': {'id': 'https://openalex.org/S174148068', 'display_name': 'Traffic', 'issn_l': '1398-9219', 'issn': ['1398-9219', '1600-0854'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/17376168', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1111/j.1600-0854.2007.00553.x', 'pdf_url': 'https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1600-0854.2007.00553.x', 'source': {'id': 'https://openalex.org/S174148068', 'display_name': 'Traffic', 'issn_l': '1398-9219', 'issn': ['1398-9219', '1600-0854'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/14', 'score': 0.62, 'display_name': 'Life below water'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 76, 'referenced_works': ['https://openalex.org/W1523314824', 'https://openalex.org/W1548999503', 'https://openalex.org/W1568990285', 'https://openalex.org/W1843137073', 'https://openalex.org/W1965476757', 'https://openalex.org/W1966072209', 'https://openalex.org/W1966223027', 'https://openalex.org/W1973214920', 'https://openalex.org/W1978141733', 'https://openalex.org/W1979274256', 'https://openalex.org/W1988418980', 'https://openalex.org/W1988816910', 'https://openalex.org/W1991411643', 'https://openalex.org/W2003417921', 'https://openalex.org/W2007230636', 'https://openalex.org/W2014176614', 'https://openalex.org/W2019125391', 'https://openalex.org/W2019215631', 'https://openalex.org/W2019897261', 'https://openalex.org/W2019987740', 'https://openalex.org/W2020212191', 'https://openalex.org/W2023420720', 'https://openalex.org/W2024812887', 'https://openalex.org/W2031198744', 'https://openalex.org/W2043830212', 'https://openalex.org/W2047801109', 'https://openalex.org/W2047809194', 'https://openalex.org/W2051410387', 'https://openalex.org/W2051459755', 'https://openalex.org/W2051894580', 'https://openalex.org/W2055786440', 'https://openalex.org/W2056079473', 'https://openalex.org/W2066972887', 'https://openalex.org/W2067397983', 'https://openalex.org/W2069212881', 'https://openalex.org/W2072508525', 'https://openalex.org/W2072544389', 'https://openalex.org/W2080442977', 'https://openalex.org/W2080443900', 'https://openalex.org/W2083087230', 'https://openalex.org/W2084983790', 'https://openalex.org/W2086959639', 'https://openalex.org/W2089340389', 'https://openalex.org/W2094866226', 'https://openalex.org/W2097544235', 'https://openalex.org/W2097780328', 'https://openalex.org/W2102645070', 'https://openalex.org/W2104176053', 'https://openalex.org/W2104268883', 'https://openalex.org/W2105469941', 'https://openalex.org/W2113947710', 'https://openalex.org/W2114816121', 'https://openalex.org/W2115732613', 'https://openalex.org/W2115778080', 'https://openalex.org/W2115912241', 'https://openalex.org/W2121586065', 'https://openalex.org/W2122730639', 'https://openalex.org/W2123460928', 'https://openalex.org/W2126467039', 'https://openalex.org/W2128625058', 'https://openalex.org/W2131623292', 'https://openalex.org/W2133987610', 'https://openalex.org/W2135859072', 'https://openalex.org/W2137148783', 'https://openalex.org/W2137576392', 'https://openalex.org/W2137943169', 'https://openalex.org/W2140408658', 'https://openalex.org/W2145625720', 'https://openalex.org/W2153091864', 'https://openalex.org/W2158164361', 'https://openalex.org/W2158866061', 'https://openalex.org/W2164186781', 'https://openalex.org/W2170283917', 'https://openalex.org/W2414472146', 'https://openalex.org/W3175283501', 'https://openalex.org/W4243741585'], 'related_works': ['https://openalex.org/W4308750618', 'https://openalex.org/W4239766472', 'https://openalex.org/W2894596463', 'https://openalex.org/W2811116997', 'https://openalex.org/W2770653741', 'https://openalex.org/W2036578410', 'https://openalex.org/W2034346780', 'https://openalex.org/W2017177922', 'https://openalex.org/W1980936182', 'https://openalex.org/W1587158131'], 'abstract_inverted_index': {'Degradation': [0], 'of': [1, 8, 50, 78, 90, 101, 116, 129, 135, 144, 153, 156, 166, 188, 194, 204], 'various': [2], 'membrane': [3], 'proteins': [4, 52, 92, 190], 'in': [5, 40, 67, 84, 96, 111, 118, 158, 168], 'the': [6, 9, 16, 41, 58, 68, 76, 99, 119, 127, 136, 145, 154, 195, 207], 'lumen': [7], 'vacuole/lysosome': [10], 'requires': [11], 'their': [12, 55], 'prior': [13, 53], 'sorting': [14, 28, 56, 89, 134, 170, 197, 203], 'into': [15, 57, 206], 'multivesicular': [17], 'body': [18], '(MVB)': [19], 'pathway.': [20, 43, 209], 'In': [21], 'this': [22, 103, 175], 'process,': [23], 'ubiquitin': [24, 35, 64, 80, 117, 159], 'serves': [25], 'as': [26], 'a': [27, 113, 163], 'signal': [29], 'for': [30, 131], 'most': [31], 'cargoes.': [32], 'The': [33], 'yeast': [34], 'hydrolase': [36], 'Doa4': [37, 130, 157, 167, 187], 'acts': [38], 'late': [39], 'MVB': [42, 88, 133, 169, 196, 208], "It's": [44], 'role': [45, 110, 155, 165, 176], 'is': [46, 81, 93, 105, 199], 'to': [47, 54, 72, 108, 201], 'catalyze': [48], 'deubiquitination': [49, 185], 'cargo': [51, 91, 138, 147, 189], 'endosomal': [59], 'vesicles.': [60], 'This': [61, 161], 'step': [62], 'rescues': [63], 'from': [65], 'degradation': [66], 'vacuole/lysosome,': [69], 'enabling': [70], 'it': [71], 'be': [73], 'recycled.': [74], 'Accordingly,': [75], 'level': [77], 'monomeric': [79], 'typically': [82], 'reduced': [83], 'doa4': [85, 97], 'mutants.': [86], 'Although': [87], 'also': [94], 'impaired': [95], 'mutants,': [98], 'question': [100], 'whether': [102], 'defect': [104], 'due': [106], 'solely': [107], 'Doa4’s': [109, 179], 'maintaining': [112], 'normal': [114], 'pool': [115], 'cell': [120], 'remains': [121], 'open.': [122], 'We': [123, 182], 'here': [124], 'show': [125, 173], 'that': [126, 174, 184], 'requirement': [128], 'correct': [132, 202], 'endocytic': [137], 'general': [139], 'amino': [140], 'acid': [141], 'permease': [142], 'and': [143, 171], 'biosynthetic': [146], 'carboxypeptidase': [148], 'S': [149], 'are': [150], 'not': [151], 'because': [152], 'recycling.': [160], 'suggests': [162], 'direct': [164], 'we': [172], 'depends': [177], 'on': [178], 'catalytic': [180], 'activity.': [181], 'propose': [183], 'by': [186], 'and/or': [191], 'some': [192], 'components': [193], 'machinery': [198], 'essential': [200], 'cargoes': [205]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2068294690', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2022, 'cited_by_count': 1}, {'year': 2021, 'cited_by_count': 1}, {'year': 2019, 'cited_by_count': 3}, {'year': 2018, 'cited_by_count': 3}, {'year': 2016, 'cited_by_count': 2}, {'year': 2014, 'cited_by_count': 5}, {'year': 2013, 'cited_by_count': 4}, {'year': 2012, 'cited_by_count': 3}], 'updated_date': '2024-09-09T17:06:50.440596', 'created_date': '2016-06-24'}