Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2068290447', 'doi': 'https://doi.org/10.1172/jci40380', 'title': 'The efficacy of activated protein C in murine endotoxemia is dependent on integrin CD11b', 'display_name': 'The efficacy of activated protein C in murine endotoxemia is dependent on integrin CD11b', 'publication_year': 2010, 'publication_date': '2010-05-10', 'ids': {'openalex': 'https://openalex.org/W2068290447', 'doi': 'https://doi.org/10.1172/jci40380', 'mag': '2068290447', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/20458145', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/2877939'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1172/jci40380', 'pdf_url': 'http://www.jci.org/articles/view/40380/files/pdf', 'source': {'id': 'https://openalex.org/S114430552', 'display_name': 'Journal of Clinical Investigation', 'issn_l': '0021-9738', 'issn': ['0021-9738', '1558-8238'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320279', 'host_organization_name': 'American Society for Clinical Investigation', 'host_organization_lineage': ['https://openalex.org/P4310320279'], 'host_organization_lineage_names': ['American Society for Clinical Investigation'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'bronze', 'oa_url': 'http://www.jci.org/articles/view/40380/files/pdf', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5080217639', 'display_name': 'Chunzhang Cao', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I126744593', 'display_name': 'University of Maryland, Baltimore', 'ror': 'https://ror.org/04rq5mt64', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I126744593']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Chunzhang Cao', 'raw_affiliation_strings': ['Center for Vascular and Inflammatory Diseases, Department of Physiology, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA.'], 'affiliations': [{'raw_affiliation_string': 'Center for Vascular and Inflammatory Diseases, Department of Physiology, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA.', 'institution_ids': ['https://openalex.org/I126744593']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5025010566', 'display_name': 'Yamei Gao', 'orcid': 'https://orcid.org/0000-0002-6913-538X'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Yamei Gao', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100421802', 'display_name': 'Yang Li', 'orcid': 'https://orcid.org/0000-0003-4022-7341'}, 'institutions': [{'id': 'https://openalex.org/I126744593', 'display_name': 'University of Maryland, Baltimore', 'ror': 'https://ror.org/04rq5mt64', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I126744593']}, {'id': 'https://openalex.org/I4210139686', 'display_name': 'National Eye Institute', 'ror': 'https://ror.org/03wkg3b53', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I1299022934', 'https://openalex.org/I1299303238', 'https://openalex.org/I4210139686']}], 'countries': ['US'], 'is_corresponding': True, 'raw_author_name': 'Yang Li', 'raw_affiliation_strings': ['National Eye Institute, NIH, Rockville, Maryland, USA.', 'University of Maryland, School of Medicine, 800 W. Baltimore Street, Baltimore, Mary-land 21201, USA.'], 'affiliations': [{'raw_affiliation_string': 'University of Maryland, School of Medicine, 800 W. Baltimore Street, Baltimore, Mary-land 21201, USA.', 'institution_ids': ['https://openalex.org/I126744593']}, {'raw_affiliation_string': 'National Eye Institute, NIH, Rockville, Maryland, USA.', 'institution_ids': ['https://openalex.org/I4210139686']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5027779533', 'display_name': 'Toni Antalis', 'orcid': 'https://orcid.org/0000-0002-0132-6171'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Toni M. Antalis', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5050593261', 'display_name': 'Francis Castellino', 'orcid': 'https://orcid.org/0000-0003-0317-9539'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Francis J. Castellino', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5100425560', 'display_name': 'Li Zhang', 'orcid': 'https://orcid.org/0000-0002-3919-3247'}, 'institutions': [{'id': 'https://openalex.org/I126744593', 'display_name': 'University of Maryland, Baltimore', 'ror': 'https://ror.org/04rq5mt64', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I126744593']}, {'id': 'https://openalex.org/I4210139686', 'display_name': 'National Eye Institute', 'ror': 'https://ror.org/03wkg3b53', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I1299022934', 'https://openalex.org/I1299303238', 'https://openalex.org/I4210139686']}], 'countries': ['US'], 'is_corresponding': True, 'raw_author_name': 'Li Zhang', 'raw_affiliation_strings': ['National Eye Institute, NIH, Rockville, Maryland, USA.', 'University of Maryland, School of Medicine, 800 W. Baltimore Street, Baltimore, Mary-land 21201, USA.'], 'affiliations': [{'raw_affiliation_string': 'University of Maryland, School of Medicine, 800 W. Baltimore Street, Baltimore, Mary-land 21201, USA.', 'institution_ids': ['https://openalex.org/I126744593']}, {'raw_affiliation_string': 'National Eye Institute, NIH, Rockville, Maryland, USA.', 'institution_ids': ['https://openalex.org/I4210139686']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 2, 'corresponding_author_ids': ['https://openalex.org/A5100421802', 'https://openalex.org/A5100425560'], 'corresponding_institution_ids': ['https://openalex.org/I126744593', 'https://openalex.org/I4210139686', 'https://openalex.org/I126744593', 'https://openalex.org/I4210139686'], 'apc_list': {'value': 5200, 'currency': 'USD', 'value_usd': 5200, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 8.602, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 118, 'citation_normalized_percentile': {'value': 0.999847, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 97, 'max': 98}, 'biblio': {'volume': '120', 'issue': '6', 'first_page': '1971', 'last_page': '1980'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10881', 'display_name': 'Thrombosis and Coagulation Disorders', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2720', 'display_name': 'Hematology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10881', 'display_name': 'Thrombosis and Coagulation Disorders', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2720', 'display_name': 'Hematology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11353', 'display_name': 'Snake Venom Evolution and Toxinology', 'score': 0.9939, 'subfield': {'id': 'https://openalex.org/subfields/1311', 'display_name': 'Genetics'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10746', 'display_name': 'Platelet Disorders and Thrombosis Mechanisms', 'score': 0.9932, 'subfield': {'id': 'https://openalex.org/subfields/2720', 'display_name': 'Hematology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/proinflammatory-cytokine', 'display_name': 'Proinflammatory cytokine', 'score': 0.46838978}, {'id': 'https://openalex.org/keywords/protease-activated-receptors', 'display_name': 'Protease-Activated Receptors', 'score': 0.446872}], 'concepts': [{'id': 'https://openalex.org/C2776816377', 'wikidata': 'https://www.wikidata.org/wiki/Q18035471', 'display_name': 'Endothelial protein C receptor', 'level': 4, 'score': 0.87720776}, {'id': 'https://openalex.org/C2781287897', 'wikidata': 'https://www.wikidata.org/wiki/Q412810', 'display_name': 'Protein C', 'level': 2, 'score': 0.69020903}, {'id': 'https://openalex.org/C171779818', 'wikidata': 'https://www.wikidata.org/wiki/Q3799301', 'display_name': 'Integrin alpha M', 'level': 3, 'score': 0.6286612}, {'id': 'https://openalex.org/C164027704', 'wikidata': 'https://www.wikidata.org/wiki/Q3491837', 'display_name': 'Proinflammatory cytokine', 'level': 3, 'score': 0.46838978}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.42044714}, {'id': 'https://openalex.org/C98274493', 'wikidata': 'https://www.wikidata.org/wiki/Q128406', 'display_name': 'Pharmacology', 'level': 1, 'score': 0.4100504}, {'id': 'https://openalex.org/C170493617', 'wikidata': 'https://www.wikidata.org/wiki/Q208467', 'display_name': 'Receptor', 'level': 2, 'score': 0.37651703}, {'id': 'https://openalex.org/C203014093', 'wikidata': 'https://www.wikidata.org/wiki/Q101929', 'display_name': 'Immunology', 'level': 1, 'score': 0.37222996}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.3694477}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.30504495}, {'id': 'https://openalex.org/C2776914184', 'wikidata': 'https://www.wikidata.org/wiki/Q101991', 'display_name': 'Inflammation', 'level': 2, 'score': 0.30060524}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.25635016}, {'id': 'https://openalex.org/C2777292125', 'wikidata': 'https://www.wikidata.org/wiki/Q409166', 'display_name': 'Thrombin', 'level': 3, 'score': 0.15721759}, {'id': 'https://openalex.org/C89560881', 'wikidata': 'https://www.wikidata.org/wiki/Q101026', 'display_name': 'Platelet', 'level': 2, 'score': 0.08441463}], 'mesh': [{'descriptor_ui': 'D019446', 'descriptor_name': 'Endotoxemia', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D016023', 'descriptor_name': 'Integrins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D011486', 'descriptor_name': 'Protein C', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D018805', 'descriptor_name': 'Sepsis', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D015055', 'descriptor_name': '1-Carboxyglutamic Acid', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D015055', 'descriptor_name': '1-Carboxyglutamic Acid', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015055', 'descriptor_name': '1-Carboxyglutamic Acid', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019446', 'descriptor_name': 'Endotoxemia', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016023', 'descriptor_name': 'Integrins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008070', 'descriptor_name': 'Lipopolysaccharides', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D008070', 'descriptor_name': 'Lipopolysaccharides', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D008070', 'descriptor_name': 'Lipopolysaccharides', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008246', 'descriptor_name': 'Lysophospholipids', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D021962', 'descriptor_name': 'Membrane Microdomains', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D021962', 'descriptor_name': 'Membrane Microdomains', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051379', 'descriptor_name': 'Mice', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008810', 'descriptor_name': 'Mice, Inbred C57BL', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018345', 'descriptor_name': 'Mice, Knockout', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017853', 'descriptor_name': 'Phosphotransferases (Alcohol Group Acceptor)', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011486', 'descriptor_name': 'Protein C', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D011486', 'descriptor_name': 'Protein C', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D011486', 'descriptor_name': 'Protein C', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018805', 'descriptor_name': 'Sepsis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013110', 'descriptor_name': 'Sphingosine', 'qualifier_ui': 'Q000031', 'qualifier_name': 'analogs & derivatives', 'is_major_topic': False}, {'descriptor_ui': 'D013110', 'descriptor_name': 'Sphingosine', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1172/jci40380', 'pdf_url': 'http://www.jci.org/articles/view/40380/files/pdf', 'source': {'id': 'https://openalex.org/S114430552', 'display_name': 'Journal of Clinical Investigation', 'issn_l': '0021-9738', 'issn': ['0021-9738', '1558-8238'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320279', 'host_organization_name': 'American Society for Clinical Investigation', 'host_organization_lineage': ['https://openalex.org/P4310320279'], 'host_organization_lineage_names': ['American Society for Clinical Investigation'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc2877939', 'pdf_url': 'https://europepmc.org/articles/pmc2877939?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2877939', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/20458145', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1172/jci40380', 'pdf_url': 'http://www.jci.org/articles/view/40380/files/pdf', 'source': {'id': 'https://openalex.org/S114430552', 'display_name': 'Journal of Clinical Investigation', 'issn_l': '0021-9738', 'issn': ['0021-9738', '1558-8238'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320279', 'host_organization_name': 'American Society for Clinical Investigation', 'host_organization_lineage': ['https://openalex.org/P4310320279'], 'host_organization_lineage_names': ['American Society for Clinical Investigation'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'display_name': 'Good health and well-being', 'score': 0.84, 'id': 'https://metadata.un.org/sdg/3'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 46, 'referenced_works': ['https://openalex.org/W107781538', 'https://openalex.org/W1508779802', 'https://openalex.org/W1515982653', 'https://openalex.org/W1520680917', 'https://openalex.org/W1566872112', 'https://openalex.org/W1570103822', 'https://openalex.org/W1787082004', 'https://openalex.org/W1814990234', 'https://openalex.org/W1956090840', 'https://openalex.org/W1966050446', 'https://openalex.org/W1973435063', 'https://openalex.org/W1976365099', 'https://openalex.org/W1980468009', 'https://openalex.org/W1991115604', 'https://openalex.org/W1991830982', 'https://openalex.org/W1998575929', 'https://openalex.org/W2000985786', 'https://openalex.org/W2010397566', 'https://openalex.org/W2014991225', 'https://openalex.org/W2018204780', 'https://openalex.org/W2020363094', 'https://openalex.org/W2022745533', 'https://openalex.org/W2026944836', 'https://openalex.org/W2038681046', 'https://openalex.org/W2038767244', 'https://openalex.org/W2039907127', 'https://openalex.org/W2055096275', 'https://openalex.org/W2063908549', 'https://openalex.org/W2068939712', 'https://openalex.org/W2071629691', 'https://openalex.org/W2087640203', 'https://openalex.org/W2105325600', 'https://openalex.org/W2105342353', 'https://openalex.org/W2114210152', 'https://openalex.org/W2130230124', 'https://openalex.org/W2140403305', 'https://openalex.org/W2149902537', 'https://openalex.org/W2156921663', 'https://openalex.org/W2159474332', 'https://openalex.org/W2161968393', 'https://openalex.org/W2163240674', 'https://openalex.org/W2166411840', 'https://openalex.org/W2171003437', 'https://openalex.org/W2322121630', 'https://openalex.org/W2783888699', 'https://openalex.org/W4313305972'], 'related_works': ['https://openalex.org/W4324272285', 'https://openalex.org/W2588943086', 'https://openalex.org/W2374546270', 'https://openalex.org/W2114460300', 'https://openalex.org/W2098076038', 'https://openalex.org/W2074866066', 'https://openalex.org/W2073933974', 'https://openalex.org/W2052733114', 'https://openalex.org/W1993601122', 'https://openalex.org/W1965306847'], 'abstract_inverted_index': {'Activated': [0], 'protein': [1, 48], 'C': [2, 49], '(APC),': [3], 'the': [4, 18, 32, 83, 91, 127, 133, 153, 174, 180, 189], 'only': [5], 'FDA-approved': [6], 'biotherapeutic': [7], 'drug': [8], 'for': [9, 100], 'sepsis,': [10], 'possesses': [11], 'anticoagulant,': [12], 'antiinflammatory,': [13], 'and': [14, 63, 67, 80, 104, 184, 200], 'barrier-protective': [15, 198], 'activities.': [16, 202], 'However,': [17], 'mechanisms': [19], 'underlying': [20, 173], 'its': [21, 101, 112, 197], 'anti\xadinflammatory': [22], 'functions': [23], 'are': [24], 'not': [25, 45, 124, 159], 'well': [26], 'defined.': [27], 'Here,': [28], 'we': [29, 147, 166], 'report': [30], 'that': [31, 54, 149, 188], 'antiinflammatory': [33, 113, 175, 190], 'activity': [34, 103, 176], 'of': [35, 69, 77, 82, 86, 90, 95, 117, 129, 144, 155, 177, 182, 192], 'APC': [36, 57, 65, 130, 150, 178, 193], 'on': [37, 41, 46, 111], 'macrophages': [38], 'is': [39, 194], 'dependent': [40], 'integrin': [42], 'CD11b/CD18,': [43], 'but': [44, 123, 158], 'endothelial': [47], 'receptor': [50], '(EPCR).': [51], 'We': [52], 'showed': [53, 148], 'CD11b/CD18': [55], 'bound': [56], 'within': [58], 'specialized': [59], 'membrane': [60], 'microdomains/lipid': [61], 'rafts': [62], 'facilitated': [64], 'cleavage': [66], 'activation': [68], 'protease-activated': [70], 'receptor–1': [71], '(PAR1),': [72], 'leading': [73], 'to': [74, 131, 168], 'enhanced': [75], 'production': [76], 'sphingosine-1-phosphate': [78], '(S1P)': [79], 'suppression': [81], 'proinflammatory': [84], 'response': [85, 136], 'activated': [87], 'macrophages.': [88], 'Deletion': [89], 'γ-carboxyglutamic': [92], 'acid': [93], 'domain': [94], 'APC,': [96], 'a': [97, 170], 'region': [98], 'critical': [99], 'anticoagulant': [102, 201], 'EPCR-dependent': [105], 'barrier': [106], 'protection,': [107], 'had': [108], 'no': [109], 'effect': [110], 'function.': [114], 'Genetic': [115], 'inactivation': [116], 'CD11b,': [118], 'PAR1,': [119], 'or': [120], 'sphingosine': [121], 'kinase–1,': [122], 'EPCR,': [125], 'abolished': [126], 'ability': [128], 'suppress': [132], 'macrophage': [134], 'inflammatory': [135], 'in': [137, 179], 'vitro.': [138], 'Using': [139], 'an': [140], 'LPS-induced': [141], 'mouse': [142], 'model': [143], 'lethal': [145], 'endotoxemia,': [146], 'administration': [151], 'reduced': [152], 'mortality': [154], 'wild-type': [156], 'mice,': [157], 'CD11b-deficient': [160], 'mice.': [161], 'These': [162], 'data': [163], 'establish': [164], 'what': [165], 'believe': [167], 'be': [169], 'novel': [171], 'mechanism': [172], 'setting': [181], 'endotoxemia': [183], 'provide': [185], 'clear': [186], 'evidence': [187], 'function': [191, 199], 'distinct': [195], 'from': [196]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2068290447', 'counts_by_year': [{'year': 2024, 'cited_by_count': 6}, {'year': 2023, 'cited_by_count': 3}, {'year': 2022, 'cited_by_count': 5}, {'year': 2021, 'cited_by_count': 4}, {'year': 2020, 'cited_by_count': 5}, {'year': 2019, 'cited_by_count': 7}, {'year': 2018, 'cited_by_count': 5}, {'year': 2017, 'cited_by_count': 8}, {'year': 2016, 'cited_by_count': 5}, {'year': 2015, 'cited_by_count': 14}, {'year': 2014, 'cited_by_count': 8}, {'year': 2013, 'cited_by_count': 18}, {'year': 2012, 'cited_by_count': 8}], 'updated_date': '2024-09-17T15:55:03.873848', 'created_date': '2016-06-24'}