Title: 460 Clinical significance of BCL-2 protein expression in renal cell carcinoma: An immunohistochemical study
Abstract: The bcl-2 protein has been related to the inhibition of programmed cell death (apoptosis), and its overexpression has been reported in several malignant tumors. In order to elucidate the clinical significance of the bcl-2 protein in renal cell carcinoma, seventy-five renal cell carcinomas were investigated by immunohistochemistry using an anti-human bcl-2 antibody. Moreover, the bcl-2 immunoreactivity was also compared with PCNA and p53 immunoreactivities as well as clinico-pathological findings. In all cases, the bcl-2 immunoreactivity was detectable in not only cancerous areas but also normal renal tubules. The bcl-2 immunoreactivity significantly correlated with M category (P < 0.05), whereas it did not with histological grade, T and N categories. On the other hand, the bcl-2 immunoreactivity inversely correlated with both PCNA and p53 immunoreactivities (P < 0.01 and P < 0.05, respectively). In addition a lower bcl-2 immunoreactivity significantly correlated with an unfavorable clinical outcome (P < 0.005), and was proved to be an independent prognostic factor using a multivariate analysis (P < 0.05). These findings suggest that the bcl-2 immunoreactivity seems to be related to the aggressive attitude of the tumor, and is one of the pivotal factors affecting prognosis in patients with renal cell carcinoma. The bcl-2 protein has been related to the inhibition of programmed cell death (apoptosis), and its overexpression has been reported in several malignant tumors. In order to elucidate the clinical significance of the bcl-2 protein in renal cell carcinoma, seventy-five renal cell carcinomas were investigated by immunohistochemistry using an anti-human bcl-2 antibody. Moreover, the bcl-2 immunoreactivity was also compared with PCNA and p53 immunoreactivities as well as clinico-pathological findings. In all cases, the bcl-2 immunoreactivity was detectable in not only cancerous areas but also normal renal tubules. The bcl-2 immunoreactivity significantly correlated with M category (P < 0.05), whereas it did not with histological grade, T and N categories. On the other hand, the bcl-2 immunoreactivity inversely correlated with both PCNA and p53 immunoreactivities (P < 0.01 and P < 0.05, respectively). In addition a lower bcl-2 immunoreactivity significantly correlated with an unfavorable clinical outcome (P < 0.005), and was proved to be an independent prognostic factor using a multivariate analysis (P < 0.05). These findings suggest that the bcl-2 immunoreactivity seems to be related to the aggressive attitude of the tumor, and is one of the pivotal factors affecting prognosis in patients with renal cell carcinoma.
Publication Year: 1995
Publication Date: 1995-11-01
Language: en
Type: article
Indexed In: ['crossref']
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