Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2068111306', 'doi': 'https://doi.org/10.1007/s12032-014-0250-y', 'title': 'Downregulation of E-cadherin expression in breast cancer by promoter hypermethylation and its relation with progression and prognosis of tumor', 'display_name': 'Downregulation of E-cadherin expression in breast cancer by promoter hypermethylation and its relation with progression and prognosis of tumor', 'publication_year': 2014, 'publication_date': '2014-09-26', 'ids': {'openalex': 'https://openalex.org/W2068111306', 'doi': 'https://doi.org/10.1007/s12032-014-0250-y', 'mag': '2068111306', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/25260805'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1007/s12032-014-0250-y', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S204953464', 'display_name': 'Medical Oncology', 'issn_l': '1357-0560', 'issn': ['1357-0560', '1559-131X'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319900', 'host_organization_name': 'Springer Science+Business Media', 'host_organization_lineage': ['https://openalex.org/P4310319965', 'https://openalex.org/P4310319900'], 'host_organization_lineage_names': ['Springer Nature', 'Springer Science+Business Media'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5006853057', 'display_name': 'Shohreh Alizadeh Shargh', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210118335', 'display_name': 'Islamic Azad University of Chalous', 'ror': 'https://ror.org/02cytaa95', 'country_code': 'IR', 'type': 'education', 'lineage': ['https://openalex.org/I4210118335']}], 'countries': ['IR'], 'is_corresponding': False, 'raw_author_name': 'Shohreh Alizadeh Shargh', 'raw_affiliation_strings': ['Medical Laboratory Science Department, Midwifery-Nursing Institute, Islamic Azad University of Chalous Branch, Chalous, Iran.'], 'affiliations': [{'raw_affiliation_string': 'Medical Laboratory Science Department, Midwifery-Nursing Institute, Islamic Azad University of Chalous Branch, Chalous, Iran.', 'institution_ids': ['https://openalex.org/I4210118335']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5062465723', 'display_name': 'Meral Sakızlı', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I193615760', 'display_name': 'Dokuz Eylül University', 'ror': 'https://ror.org/00dbd8b73', 'country_code': 'TR', 'type': 'education', 'lineage': ['https://openalex.org/I193615760']}], 'countries': ['TR'], 'is_corresponding': False, 'raw_author_name': 'Meral Sakizli', 'raw_affiliation_strings': ['Health Institute of Eylul University'], 'affiliations': [{'raw_affiliation_string': 'Health Institute of Eylul University', 'institution_ids': ['https://openalex.org/I193615760']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5065740696', 'display_name': 'Vahid Khalaj', 'orcid': 'https://orcid.org/0000-0003-1621-6394'}, 'institutions': [{'id': 'https://openalex.org/I1301411061', 'display_name': 'Pasteur Institute of Iran', 'ror': 'https://ror.org/00wqczk30', 'country_code': 'IR', 'type': 'facility', 'lineage': ['https://openalex.org/I1301411061']}], 'countries': ['IR'], 'is_corresponding': False, 'raw_author_name': 'Vahid Khalaj', 'raw_affiliation_strings': ['pasteur institute of Iran'], 'affiliations': [{'raw_affiliation_string': 'pasteur institute of Iran', 'institution_ids': ['https://openalex.org/I1301411061']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5012747365', 'display_name': 'Abolfazl Movafagh', 'orcid': 'https://orcid.org/0000-0001-7402-7677'}, 'institutions': [{'id': 'https://openalex.org/I58048189', 'display_name': 'Shahid Beheshti University of Medical Sciences', 'ror': 'https://ror.org/034m2b326', 'country_code': 'IR', 'type': 'education', 'lineage': ['https://openalex.org/I58048189']}], 'countries': ['IR'], 'is_corresponding': False, 'raw_author_name': 'Abolfazl Movafagh', 'raw_affiliation_strings': ['shahid beheshti university of medical science'], 'affiliations': [{'raw_affiliation_string': 'shahid beheshti university of medical science', 'institution_ids': ['https://openalex.org/I58048189']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5041422011', 'display_name': 'H Hagh Doust Yazdi', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210109236', 'display_name': 'Islamic Azad University of Varamin', 'ror': 'https://ror.org/01px8ca57', 'country_code': 'IR', 'type': 'education', 'lineage': ['https://openalex.org/I4210109236']}], 'countries': ['IR'], 'is_corresponding': False, 'raw_author_name': 'Hamidreza Yazdi', 'raw_affiliation_strings': ['Islamic Azad University of Varamin and Pishva Branch'], 'affiliations': [{'raw_affiliation_string': 'Islamic Azad University of Varamin and Pishva Branch', 'institution_ids': ['https://openalex.org/I4210109236']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5010751916', 'display_name': 'Elmira Hagigatjou', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I204588832', 'display_name': 'Islamic Azad University, Karaj', 'ror': 'https://ror.org/01y4xm534', 'country_code': 'IR', 'type': 'education', 'lineage': ['https://openalex.org/I204588832']}], 'countries': ['IR'], 'is_corresponding': False, 'raw_author_name': 'Elmira Hagigatjou', 'raw_affiliation_strings': ['Karaj branch, Islamic Azad University'], 'affiliations': [{'raw_affiliation_string': 'Karaj branch, Islamic Azad University', 'institution_ids': ['https://openalex.org/I204588832']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5060578800', 'display_name': 'Aresou Sayad', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I58048189', 'display_name': 'Shahid Beheshti University of Medical Sciences', 'ror': 'https://ror.org/034m2b326', 'country_code': 'IR', 'type': 'education', 'lineage': ['https://openalex.org/I58048189']}], 'countries': ['IR'], 'is_corresponding': False, 'raw_author_name': 'Aresou Sayad', 'raw_affiliation_strings': ['shahid beheshti university of medical science'], 'affiliations': [{'raw_affiliation_string': 'shahid beheshti university of medical science', 'institution_ids': ['https://openalex.org/I58048189']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5027316820', 'display_name': 'Neda Mansouri', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I58048189', 'display_name': 'Shahid Beheshti University of Medical Sciences', 'ror': 'https://ror.org/034m2b326', 'country_code': 'IR', 'type': 'education', 'lineage': ['https://openalex.org/I58048189']}], 'countries': ['IR'], 'is_corresponding': False, 'raw_author_name': 'Neda Mansouri', 'raw_affiliation_strings': ['shahid beheshti university of medical science'], 'affiliations': [{'raw_affiliation_string': 'shahid beheshti university of medical science', 'institution_ids': ['https://openalex.org/I58048189']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5085158654', 'display_name': 'Seyed Abdolreza Mortazavi‐Tabatabaei', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I58048189', 'display_name': 'Shahid Beheshti University of Medical Sciences', 'ror': 'https://ror.org/034m2b326', 'country_code': 'IR', 'type': 'education', 'lineage': ['https://openalex.org/I58048189']}], 'countries': ['IR'], 'is_corresponding': False, 'raw_author_name': 'Seyed Abdolreza Mortazavi-Tabatabaei', 'raw_affiliation_strings': ['Shahid Beheshti University of Medical Sciences'], 'affiliations': [{'raw_affiliation_string': 'Shahid Beheshti University of Medical Sciences', 'institution_ids': ['https://openalex.org/I58048189']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5064758964', 'display_name': 'Hamid Reza Khorram Khorshid', 'orcid': 'https://orcid.org/0000-0003-4485-5177'}, 'institutions': [{'id': 'https://openalex.org/I4210166308', 'display_name': 'University of Social Welfare and Rehabilitation Sciences', 'ror': 'https://ror.org/05jme6y84', 'country_code': 'IR', 'type': 'education', 'lineage': ['https://openalex.org/I4210166308']}], 'countries': ['IR'], 'is_corresponding': False, 'raw_author_name': 'Hamid Reza Khorram Khorshid', 'raw_affiliation_strings': ['University of Social Welfare and Rehabilitation Sciences'], 'affiliations': [{'raw_affiliation_string': 'University of Social Welfare and Rehabilitation Sciences', 'institution_ids': ['https://openalex.org/I4210166308']}]}], 'institution_assertions': [], 'countries_distinct_count': 2, 'institutions_distinct_count': 7, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 3090, 'currency': 'EUR', 'value_usd': 3990, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 2.607, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 64, 'citation_normalized_percentile': {'value': 0.881649, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 97, 'max': 98}, 'biblio': {'volume': '31', 'issue': '11', 'first_page': None, 'last_page': None}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10269', 'display_name': 'Epigenetic Modifications and Their Functional Implications', 'score': 0.9994, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10269', 'display_name': 'Epigenetic Modifications and Their Functional Implications', 'score': 0.9994, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T13157', 'display_name': 'Protein Arginine Methylation in Mammals', 'score': 0.9983, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10929', 'display_name': 'Wnt Signaling in Development and Disease', 'score': 0.9974, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/cdh1', 'display_name': 'CDH1', 'score': 0.9016397}, {'id': 'https://openalex.org/keywords/bisulfite-sequencing', 'display_name': 'Bisulfite sequencing', 'score': 0.611001}, {'id': 'https://openalex.org/keywords/dna-methylation', 'display_name': 'DNA Methylation', 'score': 0.521326}, {'id': 'https://openalex.org/keywords/cancer-epigenetics', 'display_name': 'Cancer Epigenetics', 'score': 0.519138}, {'id': 'https://openalex.org/keywords/cpg-site', 'display_name': 'CpG site', 'score': 0.41827083}], 'concepts': [{'id': 'https://openalex.org/C2776391639', 'wikidata': 'https://www.wikidata.org/wiki/Q17859787', 'display_name': 'CDH1', 'level': 4, 'score': 0.9016397}, {'id': 'https://openalex.org/C149402561', 'wikidata': 'https://www.wikidata.org/wiki/Q24776048', 'display_name': 'Cadherin', 'level': 3, 'score': 0.6677795}, {'id': 'https://openalex.org/C530470458', 'wikidata': 'https://www.wikidata.org/wiki/Q128581', 'display_name': 'Breast cancer', 'level': 3, 'score': 0.64966303}, {'id': 'https://openalex.org/C190727270', 'wikidata': 'https://www.wikidata.org/wiki/Q874745', 'display_name': 'DNA methylation', 'level': 4, 'score': 0.64177763}, {'id': 'https://openalex.org/C33288867', 'wikidata': 'https://www.wikidata.org/wiki/Q518328', 'display_name': 'Methylation', 'level': 3, 'score': 0.62873626}, {'id': 'https://openalex.org/C189235521', 'wikidata': 'https://www.wikidata.org/wiki/Q4087270', 'display_name': 'Bisulfite sequencing', 'level': 5, 'score': 0.611001}, {'id': 'https://openalex.org/C555283112', 'wikidata': 'https://www.wikidata.org/wiki/Q1637543', 'display_name': 'Carcinogenesis', 'level': 3, 'score': 0.60647863}, {'id': 'https://openalex.org/C41091548', 'wikidata': 'https://www.wikidata.org/wiki/Q26939', 'display_name': 'Epigenetics', 'level': 3, 'score': 0.6028537}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.56099945}, {'id': 'https://openalex.org/C121608353', 'wikidata': 'https://www.wikidata.org/wiki/Q12078', 'display_name': 'Cancer', 'level': 2, 'score': 0.50580883}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.44429892}, {'id': 'https://openalex.org/C140173407', 'wikidata': 'https://www.wikidata.org/wiki/Q1138358', 'display_name': 'CpG site', 'level': 5, 'score': 0.41827083}, {'id': 'https://openalex.org/C143998085', 'wikidata': 'https://www.wikidata.org/wiki/Q162555', 'display_name': 'Oncology', 'level': 1, 'score': 0.40389493}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.38953406}, {'id': 'https://openalex.org/C142724271', 'wikidata': 'https://www.wikidata.org/wiki/Q7208', 'display_name': 'Pathology', 'level': 1, 'score': 0.34219256}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.33888644}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.32067418}, {'id': 'https://openalex.org/C150194340', 'wikidata': 'https://www.wikidata.org/wiki/Q26972', 'display_name': 'Gene expression', 'level': 3, 'score': 0.300119}, {'id': 'https://openalex.org/C1491633281', 'wikidata': 'https://www.wikidata.org/wiki/Q7868', 'display_name': 'Cell', 'level': 2, 'score': 0.21775392}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.11275798}], 'mesh': [{'descriptor_ui': 'D001943', 'descriptor_name': 'Breast Neoplasms', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D015820', 'descriptor_name': 'Cadherins', 'qualifier_ui': 'Q000096', 'qualifier_name': 'biosynthesis', 'is_major_topic': True}, {'descriptor_ui': 'D019175', 'descriptor_name': 'DNA Methylation', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D018450', 'descriptor_name': 'Disease Progression', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D015972', 'descriptor_name': 'Gene Expression Regulation, Neoplastic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D011401', 'descriptor_name': 'Promoter Regions, Genetic', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D000328', 'descriptor_name': 'Adult', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001943', 'descriptor_name': 'Breast Neoplasms', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001943', 'descriptor_name': 'Breast Neoplasms', 'qualifier_ui': 'Q000175', 'qualifier_name': 'diagnosis', 'is_major_topic': False}, {'descriptor_ui': 'D015820', 'descriptor_name': 'Cadherins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019175', 'descriptor_name': 'DNA Methylation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015536', 'descriptor_name': 'Down-Regulation', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}, {'descriptor_ui': 'D015536', 'descriptor_name': 'Down-Regulation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005260', 'descriptor_name': 'Female', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008875', 'descriptor_name': 'Middle Aged', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011379', 'descriptor_name': 'Prognosis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011401', 'descriptor_name': 'Promoter Regions, Genetic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1007/s12032-014-0250-y', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S204953464', 'display_name': 'Medical Oncology', 'issn_l': '1357-0560', 'issn': ['1357-0560', '1559-131X'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319900', 'host_organization_name': 'Springer Science+Business Media', 'host_organization_lineage': ['https://openalex.org/P4310319965', 'https://openalex.org/P4310319900'], 'host_organization_lineage_names': ['Springer Nature', 'Springer Science+Business Media'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/25260805', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'display_name': 'Good health and well-being', 'score': 0.83, 'id': 'https://metadata.un.org/sdg/3'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 26, 'referenced_works': ['https://openalex.org/W1779082808', 'https://openalex.org/W1966313764', 'https://openalex.org/W1974123491', 'https://openalex.org/W1979588455', 'https://openalex.org/W1999701061', 'https://openalex.org/W2010467196', 'https://openalex.org/W2029413197', 'https://openalex.org/W2040257851', 'https://openalex.org/W2043053726', 'https://openalex.org/W2044827665', 'https://openalex.org/W2055026964', 'https://openalex.org/W2074229308', 'https://openalex.org/W2082643213', 'https://openalex.org/W2108215475', 'https://openalex.org/W2115128768', 'https://openalex.org/W2116993454', 'https://openalex.org/W2119955810', 'https://openalex.org/W2135789299', 'https://openalex.org/W2149355911', 'https://openalex.org/W2150515158', 'https://openalex.org/W2150823776', 'https://openalex.org/W2151395261', 'https://openalex.org/W2154797313', 'https://openalex.org/W2162647319', 'https://openalex.org/W2166892497', 'https://openalex.org/W2188543953'], 'related_works': ['https://openalex.org/W779414787', 'https://openalex.org/W4312991243', 'https://openalex.org/W3110004869', 'https://openalex.org/W3028104188', 'https://openalex.org/W3013947686', 'https://openalex.org/W2570149195', 'https://openalex.org/W2181567485', 'https://openalex.org/W2094569740', 'https://openalex.org/W2069733803', 'https://openalex.org/W1973778874'], 'abstract_inverted_index': None, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2068111306', 'counts_by_year': [{'year': 2024, 'cited_by_count': 6}, {'year': 2023, 'cited_by_count': 4}, {'year': 2022, 'cited_by_count': 6}, {'year': 2021, 'cited_by_count': 11}, {'year': 2020, 'cited_by_count': 8}, {'year': 2019, 'cited_by_count': 6}, {'year': 2018, 'cited_by_count': 1}, {'year': 2017, 'cited_by_count': 3}, {'year': 2016, 'cited_by_count': 11}, {'year': 2015, 'cited_by_count': 6}], 'updated_date': '2024-09-18T22:54:06.847687', 'created_date': '2016-06-24'}