Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2067747396', 'doi': 'https://doi.org/10.1210/me.2013-1075', 'title': 'RIG-I-Like Receptors Mediate Innate Antiviral Response in Mouse Testis', 'display_name': 'RIG-I-Like Receptors Mediate Innate Antiviral Response in Mouse Testis', 'publication_year': 2013, 'publication_date': '2013-07-03', 'ids': {'openalex': 'https://openalex.org/W2067747396', 'doi': 'https://doi.org/10.1210/me.2013-1075', 'mag': '2067747396', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/23820901', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/5415237'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1210/me.2013-1075', 'pdf_url': 'https://academic.oup.com/mend/article-pdf/27/9/1455/8939949/mend1455.pdf', 'source': {'id': 'https://openalex.org/S57449756', 'display_name': 'Molecular Endocrinology', 'issn_l': '0888-8809', 'issn': ['0888-8809', '1944-9917'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311648', 'host_organization_name': 'Oxford University Press', 'host_organization_lineage': ['https://openalex.org/P4310311647', 'https://openalex.org/P4310311648'], 'host_organization_lineage_names': ['University of Oxford', 'Oxford University Press'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'bronze', 'oa_url': 'https://academic.oup.com/mend/article-pdf/27/9/1455/8939949/mend1455.pdf', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5003820823', 'display_name': 'Weiwei Zhu', 'orcid': 'https://orcid.org/0000-0002-3275-1461'}, 'institutions': [{'id': 'https://openalex.org/I200296433', 'display_name': 'Chinese Academy of Medical Sciences & Peking Union Medical College', 'ror': 'https://ror.org/02drdmm93', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I200296433']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Weiwei Zhu', 'raw_affiliation_strings': ['School of Basic Medicine, Peking Union Medical College, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, Beijing 100005 China.'], 'affiliations': [{'raw_affiliation_string': 'School of Basic Medicine, Peking Union Medical College, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, Beijing 100005 China.', 'institution_ids': ['https://openalex.org/I200296433']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5073721190', 'display_name': 'Qiaoyuan Chen', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I200296433', 'display_name': 'Chinese Academy of Medical Sciences & Peking Union Medical College', 'ror': 'https://ror.org/02drdmm93', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I200296433']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Qiaoyuan Chen', 'raw_affiliation_strings': ['School of Basic Medicine, Peking Union Medical College, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, Beijing 100005 China.'], 'affiliations': [{'raw_affiliation_string': 'School of Basic Medicine, Peking Union Medical College, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, Beijing 100005 China.', 'institution_ids': ['https://openalex.org/I200296433']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5113744508', 'display_name': 'Keqin Yan', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I200296433', 'display_name': 'Chinese Academy of Medical Sciences & Peking Union Medical College', 'ror': 'https://ror.org/02drdmm93', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I200296433']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Keqin Yan', 'raw_affiliation_strings': ['School of Basic Medicine, Peking Union Medical College, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, Beijing 100005 China.'], 'affiliations': [{'raw_affiliation_string': 'School of Basic Medicine, Peking Union Medical College, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, Beijing 100005 China.', 'institution_ids': ['https://openalex.org/I200296433']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5102003286', 'display_name': 'Zhenghui Liu', 'orcid': 'https://orcid.org/0000-0003-4894-9744'}, 'institutions': [{'id': 'https://openalex.org/I200296433', 'display_name': 'Chinese Academy of Medical Sciences & Peking Union Medical College', 'ror': 'https://ror.org/02drdmm93', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I200296433']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Zhenghui Liu', 'raw_affiliation_strings': ['School of Basic Medicine, Peking Union Medical College, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, Beijing 100005 China.'], 'affiliations': [{'raw_affiliation_string': 'School of Basic Medicine, Peking Union Medical College, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, Beijing 100005 China.', 'institution_ids': ['https://openalex.org/I200296433']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100341113', 'display_name': 'Nan Li', 'orcid': 'https://orcid.org/0000-0003-2186-2921'}, 'institutions': [{'id': 'https://openalex.org/I200296433', 'display_name': 'Chinese Academy of Medical Sciences & Peking Union Medical College', 'ror': 'https://ror.org/02drdmm93', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I200296433']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Nan Li', 'raw_affiliation_strings': ['School of Basic Medicine, Peking Union Medical College, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, Beijing 100005 China.'], 'affiliations': [{'raw_affiliation_string': 'School of Basic Medicine, Peking Union Medical College, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, Beijing 100005 China.', 'institution_ids': ['https://openalex.org/I200296433']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100352075', 'display_name': 'Xiaoyan Zhang', 'orcid': 'https://orcid.org/0000-0002-4725-1849'}, 'institutions': [{'id': 'https://openalex.org/I200296433', 'display_name': 'Chinese Academy of Medical Sciences & Peking Union Medical College', 'ror': 'https://ror.org/02drdmm93', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I200296433']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Xiaoyan Zhang', 'raw_affiliation_strings': ['School of Basic Medicine, Peking Union Medical College, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, Beijing 100005 China.'], 'affiliations': [{'raw_affiliation_string': 'School of Basic Medicine, Peking Union Medical College, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, Beijing 100005 China.', 'institution_ids': ['https://openalex.org/I200296433']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100609003', 'display_name': 'Lili Yu', 'orcid': 'https://orcid.org/0000-0001-5832-1024'}, 'institutions': [{'id': 'https://openalex.org/I200296433', 'display_name': 'Chinese Academy of Medical Sciences & Peking Union Medical College', 'ror': 'https://ror.org/02drdmm93', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I200296433']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Lili Yu', 'raw_affiliation_strings': ['School of Basic Medicine, Peking Union Medical College, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, Beijing 100005 China.'], 'affiliations': [{'raw_affiliation_string': 'School of Basic Medicine, Peking Union Medical College, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, Beijing 100005 China.', 'institution_ids': ['https://openalex.org/I200296433']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5101644291', 'display_name': 'Yongmei Chen', 'orcid': 'https://orcid.org/0000-0001-9363-7120'}, 'institutions': [{'id': 'https://openalex.org/I200296433', 'display_name': 'Chinese Academy of Medical Sciences & Peking Union Medical College', 'ror': 'https://ror.org/02drdmm93', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I200296433']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Yongmei Chen', 'raw_affiliation_strings': ['School of Basic Medicine, Peking Union Medical College, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, Beijing 100005 China.'], 'affiliations': [{'raw_affiliation_string': 'School of Basic Medicine, Peking Union Medical College, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, Beijing 100005 China.', 'institution_ids': ['https://openalex.org/I200296433']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5078147769', 'display_name': 'Daishu Han', 'orcid': 'https://orcid.org/0000-0002-1458-4938'}, 'institutions': [{'id': 'https://openalex.org/I200296433', 'display_name': 'Chinese Academy of Medical Sciences & Peking Union Medical College', 'ror': 'https://ror.org/02drdmm93', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I200296433']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Daishu Han', 'raw_affiliation_strings': ['School of Basic Medicine, Peking Union Medical College, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, Beijing 100005 China.'], 'affiliations': [{'raw_affiliation_string': 'School of Basic Medicine, Peking Union Medical College, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, Beijing 100005 China.', 'institution_ids': ['https://openalex.org/I200296433']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 1.594, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 37, 'citation_normalized_percentile': {'value': 0.755932, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 94, 'max': 95}, 'biblio': {'volume': '27', 'issue': '9', 'first_page': '1455', 'last_page': '1467'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10371', 'display_name': 'Immune Response and Inflammation', 'score': 0.9996, 'subfield': {'id': 'https://openalex.org/subfields/2403', 'display_name': 'Immunology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10371', 'display_name': 'Immune Response and Inflammation', 'score': 0.9996, 'subfield': {'id': 'https://openalex.org/subfields/2403', 'display_name': 'Immunology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11668', 'display_name': 'interferon and immune responses', 'score': 0.9995, 'subfield': {'id': 'https://openalex.org/subfields/2403', 'display_name': 'Immunology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10580', 'display_name': 'Immunotherapy and Immune Responses', 'score': 0.9976, 'subfield': {'id': 'https://openalex.org/subfields/2403', 'display_name': 'Immunology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/tlr3', 'display_name': 'TLR3', 'score': 0.8962362}, {'id': 'https://openalex.org/keywords/mda5', 'display_name': 'MDA5', 'score': 0.82592124}, {'id': 'https://openalex.org/keywords/rig-i', 'display_name': 'RIG-I', 'score': 0.6691526}, {'id': 'https://openalex.org/keywords/proinflammatory-cytokine', 'display_name': 'Proinflammatory cytokine', 'score': 0.4214279}], 'concepts': [{'id': 'https://openalex.org/C2778420691', 'wikidata': 'https://www.wikidata.org/wiki/Q14866230', 'display_name': 'TLR3', 'level': 5, 'score': 0.8962362}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.87458026}, {'id': 'https://openalex.org/C136449434', 'wikidata': 'https://www.wikidata.org/wiki/Q428253', 'display_name': 'Innate immune system', 'level': 3, 'score': 0.8675542}, {'id': 'https://openalex.org/C134474686', 'wikidata': 'https://www.wikidata.org/wiki/Q21111069', 'display_name': 'MDA5', 'level': 5, 'score': 0.82592124}, {'id': 'https://openalex.org/C2776954689', 'wikidata': 'https://www.wikidata.org/wiki/Q21100537', 'display_name': 'RIG-I', 'level': 4, 'score': 0.6691526}, {'id': 'https://openalex.org/C2776178377', 'wikidata': 'https://www.wikidata.org/wiki/Q188269', 'display_name': 'Interferon', 'level': 2, 'score': 0.52370346}, {'id': 'https://openalex.org/C170493617', 'wikidata': 'https://www.wikidata.org/wiki/Q208467', 'display_name': 'Receptor', 'level': 2, 'score': 0.47119045}, {'id': 'https://openalex.org/C8891405', 'wikidata': 'https://www.wikidata.org/wiki/Q1059', 'display_name': 'Immune system', 'level': 2, 'score': 0.46475235}, {'id': 'https://openalex.org/C173396325', 'wikidata': 'https://www.wikidata.org/wiki/Q1501275', 'display_name': 'Gene knockdown', 'level': 3, 'score': 0.43509033}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.42466128}, {'id': 'https://openalex.org/C164027704', 'wikidata': 'https://www.wikidata.org/wiki/Q3491837', 'display_name': 'Proinflammatory cytokine', 'level': 3, 'score': 0.4214279}, {'id': 'https://openalex.org/C203014093', 'wikidata': 'https://www.wikidata.org/wiki/Q101929', 'display_name': 'Immunology', 'level': 1, 'score': 0.38332993}, {'id': 'https://openalex.org/C2776709828', 'wikidata': 'https://www.wikidata.org/wiki/Q408004', 'display_name': 'Toll-like receptor', 'level': 4, 'score': 0.30363828}, {'id': 'https://openalex.org/C2776914184', 'wikidata': 'https://www.wikidata.org/wiki/Q101991', 'display_name': 'Inflammation', 'level': 2, 'score': 0.23368227}, {'id': 'https://openalex.org/C166703698', 'wikidata': 'https://www.wikidata.org/wiki/Q201993', 'display_name': 'RNA interference', 'level': 4, 'score': 0.20451128}, {'id': 'https://openalex.org/C81885089', 'wikidata': 'https://www.wikidata.org/wiki/Q189082', 'display_name': 'Cell culture', 'level': 2, 'score': 0.19639522}, {'id': 'https://openalex.org/C67705224', 'wikidata': 'https://www.wikidata.org/wiki/Q11053', 'display_name': 'RNA', 'level': 3, 'score': 0.11543295}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.10997778}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D053487', 'descriptor_name': 'DEAD-box RNA Helicases', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D007113', 'descriptor_name': 'Immunity, Innate', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D013737', 'descriptor_name': 'Testis', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': True}, {'descriptor_ui': 'D013737', 'descriptor_name': 'Testis', 'qualifier_ui': 'Q000821', 'qualifier_name': 'virology', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016207', 'descriptor_name': 'Cytokines', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D016207', 'descriptor_name': 'Cytokines', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000071457', 'descriptor_name': 'DEAD Box Protein 58', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D053487', 'descriptor_name': 'DEAD-box RNA Helicases', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D053487', 'descriptor_name': 'DEAD-box RNA Helicases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007113', 'descriptor_name': 'Immunity, Innate', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D007113', 'descriptor_name': 'Immunity, Innate', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D050838', 'descriptor_name': 'Interferon Regulatory Factor-3', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D050838', 'descriptor_name': 'Interferon Regulatory Factor-3', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000072640', 'descriptor_name': 'Interferon-Induced Helicase, IFIH1', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007985', 'descriptor_name': 'Leydig Cells', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D007985', 'descriptor_name': 'Leydig Cells', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D007985', 'descriptor_name': 'Leydig Cells', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051379', 'descriptor_name': 'Mice', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008810', 'descriptor_name': 'Mice, Inbred C57BL', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016328', 'descriptor_name': 'NF-kappa B', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D016328', 'descriptor_name': 'NF-kappa B', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011070', 'descriptor_name': 'Poly I-C', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D011070', 'descriptor_name': 'Poly I-C', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013094', 'descriptor_name': 'Spermatozoa', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D013094', 'descriptor_name': 'Spermatozoa', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D013094', 'descriptor_name': 'Spermatozoa', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013737', 'descriptor_name': 'Testis', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D013737', 'descriptor_name': 'Testis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1210/me.2013-1075', 'pdf_url': 'https://academic.oup.com/mend/article-pdf/27/9/1455/8939949/mend1455.pdf', 'source': {'id': 'https://openalex.org/S57449756', 'display_name': 'Molecular Endocrinology', 'issn_l': '0888-8809', 'issn': ['0888-8809', '1944-9917'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311648', 'host_organization_name': 'Oxford University Press', 'host_organization_lineage': ['https://openalex.org/P4310311647', 'https://openalex.org/P4310311648'], 'host_organization_lineage_names': ['University of Oxford', 'Oxford University Press'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc5415237', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5415237', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/23820901', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1210/me.2013-1075', 'pdf_url': 'https://academic.oup.com/mend/article-pdf/27/9/1455/8939949/mend1455.pdf', 'source': {'id': 'https://openalex.org/S57449756', 'display_name': 'Molecular Endocrinology', 'issn_l': '0888-8809', 'issn': ['0888-8809', '1944-9917'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311648', 'host_organization_name': 'Oxford University Press', 'host_organization_lineage': ['https://openalex.org/P4310311647', 'https://openalex.org/P4310311648'], 'host_organization_lineage_names': ['University of Oxford', 'Oxford University Press'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/3', 'score': 0.43, 'display_name': 'Good health and well-being'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 51, 'referenced_works': ['https://openalex.org/W1523768703', 'https://openalex.org/W1540303400', 'https://openalex.org/W1803601143', 'https://openalex.org/W1967442672', 'https://openalex.org/W1971713664', 'https://openalex.org/W1973646620', 'https://openalex.org/W1976189816', 'https://openalex.org/W1976504923', 'https://openalex.org/W1983921697', 'https://openalex.org/W1987047581', 'https://openalex.org/W1999987813', 'https://openalex.org/W2000923836', 'https://openalex.org/W2004312418', 'https://openalex.org/W2012443958', 'https://openalex.org/W2020509093', 'https://openalex.org/W2031913105', 'https://openalex.org/W2048833964', 'https://openalex.org/W2061236466', 'https://openalex.org/W2076281467', 'https://openalex.org/W2079295092', 'https://openalex.org/W2080066374', 'https://openalex.org/W2092391839', 'https://openalex.org/W2093750841', 'https://openalex.org/W2095401221', 'https://openalex.org/W2095422097', 'https://openalex.org/W2096372976', 'https://openalex.org/W2098737213', 'https://openalex.org/W2102395838', 'https://openalex.org/W2110219809', 'https://openalex.org/W2114216755', 'https://openalex.org/W2115014954', 'https://openalex.org/W2115071611', 'https://openalex.org/W2120664210', 'https://openalex.org/W2124651203', 'https://openalex.org/W2135143264', 'https://openalex.org/W2138651252', 'https://openalex.org/W2139248293', 'https://openalex.org/W2143516276', 'https://openalex.org/W2144331816', 'https://openalex.org/W2151159283', 'https://openalex.org/W2154262496', 'https://openalex.org/W2154445812', 'https://openalex.org/W2157339124', 'https://openalex.org/W2161422135', 'https://openalex.org/W2165430491', 'https://openalex.org/W2168296869', 'https://openalex.org/W2287854573', 'https://openalex.org/W2424987836', 'https://openalex.org/W2443067260', 'https://openalex.org/W68316507', 'https://openalex.org/W76280644'], 'related_works': ['https://openalex.org/W4286005446', 'https://openalex.org/W3021807668', 'https://openalex.org/W2957468385', 'https://openalex.org/W2385312167', 'https://openalex.org/W2160019745', 'https://openalex.org/W2067747396', 'https://openalex.org/W2041736968', 'https://openalex.org/W2014953632', 'https://openalex.org/W1965869838', 'https://openalex.org/W1496291396'], 'abstract_inverted_index': {'The': [0, 31, 127], 'testis': [1, 165], 'is': [2, 64, 136], 'an': [3], 'immune': [4, 16, 26], 'privileged': [5], 'organ': [6], 'in': [7, 28, 59, 67, 102, 123, 132, 163], 'which': [8], 'the': [9, 29, 48, 81, 133, 164, 175], 'tissue-specific': [10], 'cells': [11, 135], 'have': [12], 'adopted': [13], 'effective': [14], 'innate': [15, 25, 50, 129], 'functions': [17], 'against': [18], 'microbial': [19], 'pathogens.': [20], 'Toll-like': [21], 'receptors': [22], '(TLRs)': [23], 'mediate': [24], 'response': [27, 131, 162], 'testis.': [30], 'current': [32], 'study': [33], 'demonstrates': [34], 'that': [35, 155], 'melanoma': [36], 'differentiation-associated': [37], 'protein': [38], '5': [39], '(MDA5)': [40], 'and': [41, 55, 62, 77, 88, 98, 107, 116, 144], 'retinoic': [42], 'acid-inducible': [43], 'gene': [44, 93], 'I': [45, 85], '(RIG-I)': [46], 'initiate': [47], 'testicular': [49, 125, 134, 178], 'antiviral': [51, 89, 130, 161, 179], 'response.': [52, 180], 'Both': [53], 'MDA5': [54, 63, 76, 143], 'RIG-I': [56, 145], 'are': [57, 118], 'expressed': [58, 66], 'Leydig': [60, 106], 'cells,': [61], 'also': [65, 152], 'spermatids.': [68], 'Polyinosinic-polycytidylic': [69], 'acid': [70], '[poly(I:C)],': [71], 'a': [72], 'common': [73], 'agonist': [74], 'of': [75, 83, 141, 158, 166], 'RIG-I,': [78], 'significantly': [79, 119, 137], 'induces': [80, 160], 'expression': [82], 'type': [84], 'interferons': [86], '(IFN-α/β)': [87], 'proteins,': [90], 'including': [91, 114], 'IFN-stimulated': [92], '15,': [94], "2'5'-oligoadenylate": [95], 'synthetase': [96], '1,': [97, 101], 'Mx': [99], 'GTPase': [100], 'primary': [103], 'TLR3-deficient': [104], '(TLR3(-/-))': [105], 'germ': [108], 'cells.': [109, 126], 'Moreover,': [110], 'major': [111], 'proinflammatory': [112], 'cytokines,': [113], 'TNF-α': [115], 'IL-6,': [117], 'up-regulated': [120], 'by': [121, 139], 'poly(I:C)': [122, 159], 'these': [124], 'poly(I:C)-induced': [128], 'reduced': [138], 'knockdown': [140], 'individual': [142], 'using': [146], 'specific': [147], 'small': [148], 'interfering': [149], 'RNA.': [150], 'We': [151], 'provide': [153, 171], 'evidence': [154], 'local': [156], 'injection': [157], 'TLR3(-/-)': [167], 'mice.': [168], 'These': [169], 'data': [170], 'novel': [172], 'insights': [173], 'into': [174], 'mechanisms': [176], 'underlying': [177]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2067747396', 'counts_by_year': [{'year': 2024, 'cited_by_count': 3}, {'year': 2022, 'cited_by_count': 2}, {'year': 2021, 'cited_by_count': 7}, {'year': 2020, 'cited_by_count': 3}, {'year': 2019, 'cited_by_count': 2}, {'year': 2018, 'cited_by_count': 1}, {'year': 2017, 'cited_by_count': 8}, {'year': 2016, 'cited_by_count': 6}, {'year': 2015, 'cited_by_count': 2}, {'year': 2014, 'cited_by_count': 3}], 'updated_date': '2025-01-18T17:58:51.872949', 'created_date': '2016-06-24'}