Publication Information

{'id': 'https://openalex.org/W2067714902', 'doi': 'https://doi.org/10.1126/science.277.5334.2005', 'title': 'Selective Expression of the Eotaxin Receptor CCR3 by Human T Helper 2 Cells', 'display_name': 'Selective Expression of the Eotaxin Receptor CCR3 by Human T Helper 2 Cells', 'publication_year': 1997, 'publication_date': '1997-09-26', 'ids': {'openalex': 'https://openalex.org/W2067714902', 'doi': 'https://doi.org/10.1126/science.277.5334.2005', 'mag': '2067714902', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/9302298'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1126/science.277.5334.2005', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S3880285', 'display_name': 'Science', 'issn_l': '0036-8075', 'issn': ['0036-8075', '1095-9203'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315823', 'host_organization_name': 'American Association for the Advancement of Science', 'host_organization_lineage': ['https://openalex.org/P4310315823'], 'host_organization_lineage_names': ['American Association for the Advancement of Science'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5047171254', 'display_name': 'Federica Sallusto', 'orcid': 'https://orcid.org/0000-0003-3750-2752'}, 'institutions': [], 'countries': ['CH', 'US'], 'is_corresponding': False, 'raw_author_name': 'Federica Sallusto', 'raw_affiliation_strings': ['C. R. MacKay, LeukoSite Inc., Cambridge, MA 02142, USA.', 'F. Sallusto and A. Lanzavecchia, Basel Institute for Immunology, Grenzacherstrasse 487, CH-4005 Basel, Switzerland.'], 'affiliations': [{'raw_affiliation_string': 'C. R. MacKay, LeukoSite Inc., Cambridge, MA 02142, USA.', 'institution_ids': []}, {'raw_affiliation_string': 'F. Sallusto and A. Lanzavecchia, Basel Institute for Immunology, Grenzacherstrasse 487, CH-4005 Basel, Switzerland.', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5068555063', 'display_name': 'Charles R. Mackay', 'orcid': 'https://orcid.org/0000-0002-6338-7340'}, 'institutions': [], 'countries': ['CH', 'US'], 'is_corresponding': False, 'raw_author_name': 'Charles R. Mackay', 'raw_affiliation_strings': ['C. R. MacKay, LeukoSite Inc., Cambridge, MA 02142, USA.', 'F. Sallusto and A. Lanzavecchia, Basel Institute for Immunology, Grenzacherstrasse 487, CH-4005 Basel, Switzerland.'], 'affiliations': [{'raw_affiliation_string': 'F. Sallusto and A. Lanzavecchia, Basel Institute for Immunology, Grenzacherstrasse 487, CH-4005 Basel, Switzerland.', 'institution_ids': []}, {'raw_affiliation_string': 'C. R. MacKay, LeukoSite Inc., Cambridge, MA 02142, USA.', 'institution_ids': []}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5059965999', 'display_name': 'Antonio Lanzavecchia', 'orcid': 'https://orcid.org/0000-0002-3041-7240'}, 'institutions': [], 'countries': ['CH', 'US'], 'is_corresponding': False, 'raw_author_name': 'Antonio Lanzavecchia', 'raw_affiliation_strings': ['C. R. MacKay, LeukoSite Inc., Cambridge, MA 02142, USA.', 'F. Sallusto and A. Lanzavecchia, Basel Institute for Immunology, Grenzacherstrasse 487, CH-4005 Basel, Switzerland.'], 'affiliations': [{'raw_affiliation_string': 'F. Sallusto and A. Lanzavecchia, Basel Institute for Immunology, Grenzacherstrasse 487, CH-4005 Basel, Switzerland.', 'institution_ids': []}, {'raw_affiliation_string': 'C. R. MacKay, LeukoSite Inc., Cambridge, MA 02142, USA.', 'institution_ids': []}]}], 'institution_assertions': [], 'countries_distinct_count': 2, 'institutions_distinct_count': 0, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 59.701, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 1073, 'citation_normalized_percentile': {'value': 0.999901, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 99, 'max': 100}, 'biblio': {'volume': '277', 'issue': '5334', 'first_page': '2005', 'last_page': '2007'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10051', 'display_name': 'Asthma and respiratory diseases', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2737', 'display_name': 'Physiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10051', 'display_name': 'Asthma and respiratory diseases', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2737', 'display_name': 'Physiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10877', 'display_name': 'Allergic Rhinitis and Sensitization', 'score': 0.9992, 'subfield': {'id': 'https://openalex.org/subfields/2723', 'display_name': 'Immunology and Allergy'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11346', 'display_name': 'Mast cells and histamine', 'score': 0.9986, 'subfield': {'id': 'https://openalex.org/subfields/2403', 'display_name': 'Immunology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/ccr3', 'display_name': 'CCR3', 'score': 0.60270524}, {'id': 'https://openalex.org/keywords/cc-chemokine-receptors', 'display_name': 'CC chemokine receptors', 'score': 0.49107337}, {'id': 'https://openalex.org/keywords/interleukin-3', 'display_name': 'Interleukin 3', 'score': 0.45393312}], 'concepts': [{'id': 'https://openalex.org/C2777716647', 'wikidata': 'https://www.wikidata.org/wiki/Q5381961', 'display_name': 'Eotaxin', 'level': 4, 'score': 0.637917}, {'id': 'https://openalex.org/C1423137', 'wikidata': 'https://www.wikidata.org/wiki/Q21113928', 'display_name': 'CCR3', 'level': 5, 'score': 0.60270524}, {'id': 'https://openalex.org/C129374314', 'wikidata': 'https://www.wikidata.org/wiki/Q909381', 'display_name': 'Interleukin 21', 'level': 4, 'score': 0.5537987}, {'id': 'https://openalex.org/C128879288', 'wikidata': 'https://www.wikidata.org/wiki/Q5009764', 'display_name': 'CC chemokine receptors', 'level': 5, 'score': 0.49107337}, {'id': 'https://openalex.org/C2776090121', 'wikidata': 'https://www.wikidata.org/wiki/Q193529', 'display_name': 'T cell', 'level': 3, 'score': 0.49067986}, {'id': 'https://openalex.org/C154317977', 'wikidata': 'https://www.wikidata.org/wiki/Q376266', 'display_name': 'Cytotoxic T cell', 'level': 3, 'score': 0.4838106}, {'id': 'https://openalex.org/C203014093', 'wikidata': 'https://www.wikidata.org/wiki/Q101929', 'display_name': 'Immunology', 'level': 1, 'score': 0.47631916}, {'id': 'https://openalex.org/C131665280', 'wikidata': 'https://www.wikidata.org/wiki/Q14866169', 'display_name': 'Interleukin 3', 'level': 5, 'score': 0.45393312}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.4331669}, {'id': 'https://openalex.org/C54166955', 'wikidata': 'https://www.wikidata.org/wiki/Q658145', 'display_name': 'Chemotaxis', 'level': 3, 'score': 0.41292727}, {'id': 'https://openalex.org/C153911025', 'wikidata': 'https://www.wikidata.org/wiki/Q7202', 'display_name': 'Molecular biology', 'level': 1, 'score': 0.40300274}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.3800956}, {'id': 'https://openalex.org/C170493617', 'wikidata': 'https://www.wikidata.org/wiki/Q208467', 'display_name': 'Receptor', 'level': 2, 'score': 0.3576085}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.35177433}, {'id': 'https://openalex.org/C202751555', 'wikidata': 'https://www.wikidata.org/wiki/Q221681', 'display_name': 'In vitro', 'level': 2, 'score': 0.30339774}, {'id': 'https://openalex.org/C13373296', 'wikidata': 'https://www.wikidata.org/wiki/Q421866', 'display_name': 'Chemokine', 'level': 3, 'score': 0.27736002}, {'id': 'https://openalex.org/C12823836', 'wikidata': 'https://www.wikidata.org/wiki/Q24720618', 'display_name': 'Chemokine receptor', 'level': 4, 'score': 0.24047941}, {'id': 'https://openalex.org/C2776914184', 'wikidata': 'https://www.wikidata.org/wiki/Q101991', 'display_name': 'Inflammation', 'level': 2, 'score': 0.21593243}, {'id': 'https://openalex.org/C8891405', 'wikidata': 'https://www.wikidata.org/wiki/Q1059', 'display_name': 'Immune system', 'level': 2, 'score': 0.17015383}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.062004536}], 'mesh': [{'descriptor_ui': 'D019742', 'descriptor_name': 'Chemokines, CC', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D016207', 'descriptor_name': 'Cytokines', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D019707', 'descriptor_name': 'Receptors, Chemokine', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D018121', 'descriptor_name': 'Receptors, Cytokine', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D018418', 'descriptor_name': 'Th2 Cells', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D018418', 'descriptor_name': 'Th2 Cells', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D000328', 'descriptor_name': 'Adult', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002118', 'descriptor_name': 'Calcium', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D002118', 'descriptor_name': 'Calcium', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002460', 'descriptor_name': 'Cell Line', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002469', 'descriptor_name': 'Cell Separation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D054413', 'descriptor_name': 'Chemokine CCL11', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002634', 'descriptor_name': 'Chemotaxis, Leukocyte', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002999', 'descriptor_name': 'Clone Cells', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016207', 'descriptor_name': 'Cytokines', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D016207', 'descriptor_name': 'Cytokines', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016898', 'descriptor_name': 'Interferon-alpha', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D016898', 'descriptor_name': 'Interferon-alpha', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007371', 'descriptor_name': 'Interferon-gamma', 'qualifier_ui': 'Q000096', 'qualifier_name': 'biosynthesis', 'is_major_topic': False}, {'descriptor_ui': 'D007371', 'descriptor_name': 'Interferon-gamma', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007377', 'descriptor_name': 'Interleukin-3', 'qualifier_ui': 'Q000096', 'qualifier_name': 'biosynthesis', 'is_major_topic': False}, {'descriptor_ui': 'D007377', 'descriptor_name': 'Interleukin-3', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015847', 'descriptor_name': 'Interleukin-4', 'qualifier_ui': 'Q000096', 'qualifier_name': 'biosynthesis', 'is_major_topic': False}, {'descriptor_ui': 'D015847', 'descriptor_name': 'Interleukin-4', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D054397', 'descriptor_name': 'Receptors, CCR3', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018121', 'descriptor_name': 'Receptors, Cytokine', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018418', 'descriptor_name': 'Th2 Cells', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016212', 'descriptor_name': 'Transforming Growth Factor beta', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016212', 'descriptor_name': 'Transforming Growth Factor beta', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1126/science.277.5334.2005', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S3880285', 'display_name': 'Science', 'issn_l': '0036-8075', 'issn': ['0036-8075', '1095-9203'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315823', 'host_organization_name': 'American Association for the Advancement of Science', 'host_organization_lineage': ['https://openalex.org/P4310315823'], 'host_organization_lineage_names': ['American Association for the Advancement of Science'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/9302298', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/3', 'display_name': 'Good health and well-being', 'score': 0.61}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 30, 'referenced_works': ['https://openalex.org/W1856738731', 'https://openalex.org/W1966286149', 'https://openalex.org/W1976186260', 'https://openalex.org/W1979514172', 'https://openalex.org/W1988227673', 'https://openalex.org/W1989680178', 'https://openalex.org/W2002726220', 'https://openalex.org/W2004216239', 'https://openalex.org/W2023520187', 'https://openalex.org/W2028293869', 'https://openalex.org/W2032494769', 'https://openalex.org/W2033043906', 'https://openalex.org/W2037061225', 'https://openalex.org/W2042626190', 'https://openalex.org/W2050851156', 'https://openalex.org/W2060088029', 'https://openalex.org/W2063541345', 'https://openalex.org/W2087372329', 'https://openalex.org/W2089237353', 'https://openalex.org/W2109506765', 'https://openalex.org/W2131761283', 'https://openalex.org/W2134908518', 'https://openalex.org/W2137664573', 'https://openalex.org/W2140627356', 'https://openalex.org/W2160272188', 'https://openalex.org/W2161485037', 'https://openalex.org/W2163295981', 'https://openalex.org/W2163885960', 'https://openalex.org/W2172466148', 'https://openalex.org/W2315018741'], 'related_works': ['https://openalex.org/W4299688008', 'https://openalex.org/W4230911507', 'https://openalex.org/W2412923924', 'https://openalex.org/W2336300624', 'https://openalex.org/W2137664573', 'https://openalex.org/W2079121196', 'https://openalex.org/W2077458495', 'https://openalex.org/W2013132903', 'https://openalex.org/W2005558297', 'https://openalex.org/W1987886332'], 'abstract_inverted_index': {'There': [0], 'is': [1], 'growing': [2], 'evidence': [3], 'that': [4, 86], 'T': [5, 13, 28, 33, 69, 81, 90, 98, 105, 120, 125], 'helper': [6], 'cell': [7, 93], 'subsets': [8], '(T': [9], 'H': [10, 14, 29, 34, 70, 91, 99, 126], '1': [11, 30], 'and': [12, 41, 60, 95, 115, 147, 153], '2)': [15], 'can': [16], 'be': [17, 66], 'differentially': [18], 'recruited': [19, 38], 'to': [20, 65, 75, 79, 89, 96, 150], 'promote': [21], 'different': [22], 'types': [23], 'of': [24, 117, 124, 145], 'inflammatory': [25], 'reactions.': [26, 51], 'Murine': [27], 'but': [31], 'not': [32], '2': [35, 71, 100, 127], 'cells': [36, 82, 101, 106, 128], 'are': [37], 'through': [39], 'P-': [40], 'E-selectin': [42], 'into': [43], 'inflamed': [44], 'tissues,': [45], 'where': [46], 'they': [47], 'induce': [48], 'delayed-type': [49], 'hypersensitivity': [50], 'The': [52, 122], 'human': [53], 'eotaxin-receptor': [54], 'CCR3,': [55], 'originally': [56], 'described': [57], 'on': [58], 'eosinophils': [59], 'basophils,': [61], 'was': [62, 77], 'also': [63], 'found': [64], 'expressed': [67], 'by': [68, 129], 'cells.': [72, 121], 'An': [73], 'antibody': [74], 'CCR3': [76, 118], 'used': [78], 'isolate': [80], 'from': [83, 103], 'peripheral': [84], 'blood': [85], 'give': [87], 'rise': [88], '2-polarized': [92], 'lines': [94], 'identify': [97], 'derived': [102], 'naı̈ve': [104], 'in': [107, 112, 136], 'vitro.': [108], 'Eotaxin': [109], 'stimulated': [110], 'increases': [111], 'intracellular': [113], 'calcium': [114], 'chemotaxis': [116], '+': [119], 'attraction': [123], 'eotaxin': [130], 'could': [131], 'represent': [132], 'a': [133], 'key': [134], 'mechanism': [135], 'allergic': [137], 'reactions,': [138], 'because': [139], 'it': [140], 'promotes': [141], 'the': [142], 'allergen-driven': [143], 'production': [144], 'interleukin-4': [146], 'interleukin-5': [148], 'necessary': [149], 'activate': [151], 'basophils': [152], 'eosinophils.': [154]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2067714902', 'counts_by_year': [{'year': 2024, 'cited_by_count': 7}, {'year': 2023, 'cited_by_count': 8}, {'year': 2022, 'cited_by_count': 8}, {'year': 2021, 'cited_by_count': 13}, {'year': 2020, 'cited_by_count': 12}, {'year': 2019, 'cited_by_count': 8}, {'year': 2018, 'cited_by_count': 13}, {'year': 2017, 'cited_by_count': 25}, {'year': 2016, 'cited_by_count': 20}, {'year': 2015, 'cited_by_count': 12}, {'year': 2014, 'cited_by_count': 23}, {'year': 2013, 'cited_by_count': 32}, {'year': 2012, 'cited_by_count': 24}], 'updated_date': '2024-12-15T09:36:40.395012', 'created_date': '2016-06-24'}