Publication Information

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[332], '(2).': [333], 'challenges': [335], 'previous': [336], 'provides': [343], 'insight': [345, 1467], 'into': [346, 659, 1010, 1460, 1468, 1612], 'Treg': [347, 363, 392, 934, 1051, 1072, 1099, 1248, 1277, 1329, 1469, 1615, 1643], 'biology.': [348], 'capitalizes': [350], 'system’s': [354], 'endogenous': [355, 650, 907], 'mechanisms.': [357], 'Key': [358], 'among': [359], 'CD4+': [362], 'cells.': [364, 756, 1142], 'Five': [365], 'ten': [367], 'percent': [368], 'CD4': [370, 680, 712, 729, 746, 1549, 1588], 'emerging': [372], 'from': [373, 826, 951, 995], 'thymus': [375, 1560], 'constitutively': [376], 'express': [377, 1128, 1563, 1626], 'CD25': [378, 401, 715, 769, 1109], '(IL-2R': [379], 'α-chain)': [380], 'activation': [383, 1570, 1601], 'markers': [384], '(3).': [385], 'Depletion': [386], 'cells,': [389, 417, 747, 809, 1091, 1596], 'dubbed': [390], 'natural': [391], '(NTregs),': [394], 'precipitates': [395], 'systemic': [396, 435], 'autoimmunity': [397], 'mice.': [399], 'Unlike': 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'induction': [472, 502, 854], 'role': [475, 498, 512], 'versusNTregs': [478], 'remains': [479], 'unclear': [480], '(Figure': [481, 682], '1).': [482, 683], 'experimental': [484], 'models,': [485], 'Tregs': [486, 524, 555, 651, 660, 878, 891, 908, 958, 1171, 1176, 1209, 1290, 1341, 1437, 1522], 'can': [487, 645, 706, 814, 902, 1389, 1579, 1610], 'autoimmunity,': [489], 'graft-versus-host': [491], 'disease': [492, 1502], '(GVHD),': [493], 'play': [495], 'an': [496, 954], 'important': [497, 511, 640, 1490], 'both': [500], '(3–5).': [508], 'Given': [509], 'their': [510], 'homeostasis,': [515], 'there': [516, 540, 982], 'great': [518], 'interest': [519], 'manipulate': [523], 'therapeutic': [526, 1338, 1475], 'advantage.': [527], 'present': [532, 633], 'even': [533], 'transplant': [535, 563, 841, 942], 'conventional': [538], 'immunosuppressives,': [539], 'hope': [542], 'boosting': [544], 'such': [547, 602, 1045, 1572], 'humans,': [553, 1066], 'CD25+': [554, 745, 787, 806, 1125, 1183, 1207, 1658], 'shown': [558], 'increased': [561, 955, 1113], 'patients': [564, 583, 589, 943, 966], 'stable': [566, 945], 'graft': [567, 946], 'function': [568, 947, 1052, 1083], '(6,7).': [569], 'Moreover,': [570, 900, 940, 1285, 1333, 1443], 'recent': [572], 'study': [573, 686], 'notes': [574], 'although': [576, 1055, 1092], 'mRNA': [578], 'increases': [579, 593], 'urine': [581], 'undergoing': [584], 'acute': [585], 'renal': [586], 'rejection,': [588], 'highest': [592], 'were': [594, 949], 'responsive': [596], 'treatment': [598, 1262, 1499], '(8).': [599], 'Based': [600], 'findings,': [603], 'several': [604], 'groups': [605], 'attempting': [607], 'ex': [608, 893, 1172, 1212, 1438], 'expansion': [610, 935, 1214, 1435], 'pre-existent': [612], 'followed': [614], 'reinfusion,': [616], 'prevention/treatment': [621], 'GVHD': [623], 'type': [625], '1': [626], 'diabetes': [627, 916], '(5).': [628], 'cell': [630, 704, 1018, 1217, 1550, 1569], 'culture': [631], 'approaches': [632], 'significant': [635], 'it': [638, 668, 833, 1067], 'boost': [646], 'number': [648, 726, 743], 'and/or': [652], 'induce': [653, 707], 'conversion': [654, 749, 1457], 'nonregulatory': [656, 1459], 'vivo.': [662, 1173, 1264, 1442], 'Conversion': [663], 'particularly': [665], 'attractive': [666], 'because': [667, 981], 'targets': [669], '90': [670], '95%': [672], '(rather': [673], '5': [675], '10%)': [677], 'population': [681], 'Enter': [684], 'which': [691, 810], 'shows': [692, 834, 1118], 'rabbit': [694], 'antithymocyte': [695, 1650], 'globulin': [696, 1320, 1651], '(ATG),': [697], 'widely': [698, 837], 'believed': [699], 'immunosuppress': [701], 'depletion,': [705], 'five-fold': [709, 803], 'increase': [710, 740, 761, 804], 'just': [719], '24': [720, 812], 'h': [721, 813], 'vitro.': [723], 'Although': [724, 1586], 'CD25−': [728, 755, 794], 'decreased': [731], 'ATG,': [733], 'was': [735, 1084, 1101], 'accompanied': [736], 'similar': [739], 'suggesting': [748], 'selective': [752], 'depletion': [753, 1298], 'agreement,': [758], 'multi-fold': [760], 'cannot': [762, 1135], 'explained': [764, 817], 'proliferation': [766, 1656], 'pre-existing': [768], 'given': [771], 'short': [773], 'time-frame,': [774], 'indeed': [776], '5,6-carboxyfluorescein': [777], 'diacetate': [778], 'succinimidyl': [779], 'ester': [780], '(CFSE)': [781], 'labeling': [782], 'revealed': [783], '16%': [785], 'had': [789], 'proliferated.': [790], 'Finally,': [791], 'incubation': [792, 1194], 'Foxp3−': [795, 1008, 1039], 'ATG': [798, 994, 1112, 1164, 1196, 1236, 1242, 1348, 1370, 1423, 1452], 'results': [800], 'Foxp3+': [808, 877, 1011, 1175, 1659], 'phenotypic': [819], 'conversion.': [820], 'What': [821, 992, 1223], 'does': [822, 1225], 'finding': [824], 'mean': [825], 'biologic': [828], 'perspective?': [831], 'used': [838, 1167, 1199, 1307], 'merely': [845], 'immunosuppress,': [846], 'but': [847, 1088], 'actively': [849], 'engraftment': [851], 'Tregs.': [856], 'regard,': [859, 1106], 'rapamycin': [860, 901, 1350], 'appears': [861, 1314, 1653], 'preferentially': [863], 'inhibit': [864, 933], 'growth': [865, 905], 'stimulated': [870], 'vitro,': [872], 'favoring': [873], 'outgrowth': [875], '(9).': [879], 'property': [881, 923], 'already': [883], 'being': [884], 'utilized': [885], 'enhance': [887, 1521], 'purity': [889], 'grown': [892], 'above.': [899, 1222], 'over': [909], 'effectors': [911, 1513], 'vivo,': [913], 'limiting': [914], 'autoimmune': [915, 1501], '(10).': [917], 'shared': [924], 'all': [926], 'agents,': [928], 'calcineurin': [930], 'inhibitors': [931], '(CNI)': [932], 'activity': [938, 1100], '(11).': [939], 'liver': [941], 'who': [948], 'withdrawn': [950], 'exhibited': [953], 'percentage': [956], '(7).': [959], 'say': [964], 'CNI': [968], '(6),': [973], 'shifted': [980], 'them': [986], 'active.': [991], 'distinguishes': [993], '(e.g.,': [998, 1600], 'IL-10': [999, 1606], 'TGF-β)': [1001, 1608], 'ability': [1004], 'rapidly': [1006], 'convert': [1007], 'proliferation.': [1019], 'It': [1020], 'should': [1021], 'unlike': [1025], 'mice,': [1026], 'expression': [1029, 1057, 1110, 1132, 1155], 'highly': [1031], 'restricted,': [1032], 'human': [1038, 1140, 1160], 'normal': [1042], 'activation.': [1043], 'Nonetheless,': [1044], 'appear': [1048, 1249], 'exhibit': [1050], '(12).': [1053], 'Thus,': [1054, 1163], 'per': [1063, 1133], 'se,': [1064], 'identifies': [1069], 'activity.': [1073, 1616], 'supported': [1076], 'study,': [1080], 'suppressor': [1082], 'seen': [1085], 'treated': [1087], 'untreated': [1090], 'actual': [1094], 'phenotype': [1095], 'defined.': [1103], 'proportionally,': [1114], 'data': [1117], '20': [1121], '25%': [1123], 'Foxp3.': [1129], 'Unfortunately,': [1130], 'se': [1134], 'monitored': [1137], 'live': [1139], 'Liu': [1144], 'recently': [1147], 'showed': [1148], 'IL-7': [1150], 'receptor': [1151, 1218], '(CD127)': [1152], 'inversely': [1157], 'correlated': [1158], '(13).': [1162], 'expand': [1170, 1580], 'comprise': [1178], 'minority': [1180], 'population,': [1184], 'enriched': [1188], 'CD127−': [1191, 1208], 'subpopulation.': [1192], 'Alternatively,': [1193], 'significantly': [1201, 1253, 1274], 'augment': [1202, 1655], 'precusor': [1204], 'frequency': [1205], 'before': [1210], 'further': [1211], 'stimulation,': [1219], 'implications': [1224], 'article': [1227], 'vivo?': [1238], 'Optimal': [1239], 'concentrations': [1240], 'vitro': [1245], 'occur': [1251, 1280], 'lower': [1254], 'those': [1257, 1518], 'serum': [1260], 'antibody': [1266], 'secondary': [1269], 'lymphoid': [1270], 'tissues': [1271], 'lower,': [1275], 'so': [1276], 'relevant': [1283], 'locations.': [1284], 'relative': [1287], 'resistance': [1288], 'apoptosis': [1292], 'preferential': [1297], 'effectors.': [1301], 'Indeed': [1302], 'strategy': [1304], 'others': [1309, 1629], 'generate': [1311, 1664], 'operative': [1315], 'receiving': [1318], 'antilymphocyte': [1319], '(14,15).': [1321], 'Clearly,': [1322], 'optimizing': [1326], 'doses': [1327], 'needed.': [1332], 'above': [1335, 1384], 'enhancement': [1339], 'best': [1343], 'combining': [1347], 'CNI.': [1353], 'Whether': [1354], 'will': [1356, 1424, 1464, 1514, 1534], 'sufficient': [1358], 'keep': [1360], 'response': [1364], 'bay': [1366], 'withdrawal': [1368], 'serious': [1373], 'concern.': [1374], 'Regardless,': [1375], 'indicate': [1385], 'tolerogenic': [1391, 1530], 'roles': [1392], 'mediated': [1393], 'Tregs,': [1397], 'learn': [1404], 'using': [1406], 'context.': [1412], 'summary,': [1414], 'soon': [1425], 'examined': [1427], 'adjunctive': [1429], 'enhancing': [1434], 'identification': [1444], 'surface': [1447], 'molecules': [1448], 'targeted': [1449], 'polyclonal': [1451], 'preparations': [1453], 'mediate': [1456], 'provide': [1465], 'biology': [1470], 'allow': [1472], 'more': [1479, 1537], 'generating': [1484], 'Treg.': [1485], 'Such': [1486], 'would': [1488], 'impact': [1491], 'well': [1495, 1662], 'glomerulonephritis': [1504], '(5,16).': [1505], 'Ultimately,': [1506], 'effectively': [1510], 'control': [1511], 'efficiently': [1520], 'differences': [1528], 'spectrum': [1540], 'black': [1544], 'white.Figure': [1546], '1:': [1547], 'Regulatory': [1548], 'populations.': [1551], 'Natural': [1552], '(NTreg)': [1556], 'addition': [1566], 'CD25,': [1574], 'CTLA-4,': [1575], 'GITR.': [1577], 'NTreg': [1578], 'proliferating': [1582], 'periphery.': [1585], 'Foxp3-': [1587], 'primarily': [1590], 'give': [1591], 'rise': [1592], 'peripheral': [1594], 'circumstances': [1599], 'influence': [1604], 'Some': [1617], '(referred': [1620, 1630], 'here': [1622, 1632], 'NTregs)': [1625], 'adaptive': [1634], 'Tregs)': [1635], 'remain': [1636], 'Foxp3-negative.': [1637], 'distinctions': [1639], 'three': [1642], 'currently': [1646], 'investigation.': [1648], 'Rabbit': [1649], '(ATG)': [1652]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2067682254', 'counts_by_year': [{'year': 2014, 'cited_by_count': 1}, {'year': 2013, 'cited_by_count': 1}, {'year': 2012, 'cited_by_count': 2}], 'updated_date': '2024-12-10T11:24:32.062701', 'created_date': '2016-06-24'}