Ceruloplasmin Ferroxidase Activity Stimulates Cellular Iron Uptake by a Trivalent Cation-specific Transport Mechanism

Name: Work Video:
Duration: 3 min 30 s
Zouhair K. Attieh; Chinmay K. Mukhopadhyay; Vasudevan Seshadri; Nicholas A. Tripoulas; Paul L. Fox
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'its': [44, 277, 731, 763, 947, 1329, 1467, 4159, 4359, 4366], 'potent': [45, 278], 'ferroxidase': [46, 187, 279, 420, 1553, 1835, 2535, 2728, 3742, 4102, 4110, 4132, 4206, 4239, 4299, 4360, 4389], 'activity': [47, 188, 280, 421, 1554, 1836, 2729, 3743, 4103, 4111, 4133, 4162, 4207, 4240, 4300, 4361, 4370, 4390], 'catalyzing': [48, 281], 'conversion': [49, 282, 1557, 3164, 3735], 'Fe2+': [51, 284, 3167, 3229, 3737, 4064], 'Fe3+,': [53, 286], 'identification': [55, 288], 'yeast': [57, 290, 1259, 1336, 1643], 'copper': [58, 291, 1367, 1549, 2396, 2605, 2648, 4127, 4251, 4342], 'oxidases': [59, 292, 1504], 'homologous': [60, 293, 1292], 'Cp': [62, 88, 105, 110, 180, 186, 202, 205, 221, 295, 321, 338, 343, 413, 419, 435, 438, 454, 1546, 1568, 1586, 1619, 1729, 1749, 1818, 1834, 1847, 1855, 2197, 2395, 2435, 2657, 2727, 2759, 2762, 2849, 2923, 2952, 2979, 2999, 3027, 3064, 3138, 3151, 3257, 3312, 3430, 3476, 3494, 3574, 3596, 3698, 3741, 3777, 3897, 4073, 4081, 4109, 4131, 4153, 4183, 4189, 4238, 4354, 4384, 4418], 'that': [63, 87, 179, 296, 320, 412, 774, 1087, 1493, 1555, 1585, 1725, 1829, 1879, 2848, 3097, 3110, 3121, 3137, 3150, 3401, 3464, 3493, 3507, 3776, 3872, 3885, 4080, 4388, 4399, 4417], 'facilitate': [64, 297, 1316, 3747], 'high': [65, 230, 298, 463, 1317, 2851], 'affinity': [66, 299, 948, 1318, 2852, 3112], 'uptake,': [68, 301, 2085, 2885, 3966, 4396], 'studies': [71, 304, 818, 834, 3045], '"aceruloplasminemic"': [73, 306], 'patients': [74, 307, 1727], 'who': [75, 308, 3671], 'have': [76, 84, 309, 317, 618, 1085, 1151, 1255, 1582, 1732, 2845], 'extensive': [77, 310], 'deposits': [79, 312, 1735], 'tissues.': [82, 315], 'We': [83, 209, 316, 442, 1581, 2844, 4117], 'recently': [85, 318, 1153, 1584], 'shown': [86, 195, 319, 428, 815, 1583, 2473, 2847, 3453, 4318], 'increases': [89, 322, 1587, 1819, 4419], 'cultured': [93, 326, 768, 1012], 'HepG2': [94, 327, 1015, 1592, 1622, 2857, 2919, 3047, 3630, 3681], 'cells.': [95, 328, 1054, 1825, 3682], 'In': [96, 329, 516, 701, 1808, 2342, 2757, 3309, 4060], 'this': [97, 330, 702, 1000, 1809, 3212, 3310, 3330, 3526, 3619, 3820], 'report,': [98, 331], 'we': [99, 332, 1811, 2886, 3172, 4451], 'investigated': [100, 333], 'mechanism': [102, 335, 1815, 2881], 'which': [104, 214, 337, 447, 1505, 1817, 2836, 2921, 3788, 4224], 'stimulates': [106, 339, 2850, 3575, 3778, 4082], 'uptake.': [109, 342, 1498, 1580, 4076, 4193, 4464], 'stimulated': [111, 344, 3065, 3139, 3313], 'rate': [113, 346, 3090], 'non-transferrin': [115, 348, 1098, 1252], '55Fe': [116, 349, 1588, 2156, 3848, 4057], 'iron-deficient': [119, 352, 1322, 1591, 2003, 2182, 2856, 2983, 3031, 3264, 3440, 4290], 'K562': [120, 353, 1037, 1824, 1981, 2089, 2177, 2890, 2947, 2984, 3265, 3291, 3532, 3582, 3796, 4291], 'cells': [121, 354, 769, 1013, 1157, 1593, 1623, 1982, 2000, 2020, 2090, 2207, 2858, 2891, 2920, 2948, 2985, 3032, 3037, 3048, 3214, 3266, 3292, 3298, 3441, 3471, 3502, 3533, 3583, 3631, 3797, 4185, 4292], '2–3-fold,': [123, 356], 'using': [124, 357, 3176, 3269, 3860, 3984, 4114], 'a': [125, 146, 182, 211, 358, 379, 415, 444, 486, 709, 918, 1105, 1548, 1552, 1570, 1595, 1839, 2052, 2118, 2159, 2240, 2343, 2366, 2733, 2768, 2832, 2875, 3008, 3041, 3177, 3218, 3315, 3396, 3424, 3485, 3508, 3562, 3673, 3827, 3861, 3969, 4047, 4083, 4090, 4099, 4226, 4349, 4409], 'receptor-independent': [127, 360, 1597], 'pathway.': [128, 361, 700, 1844], 'Induction': [129, 362], 'Cp-stimulated': [131, 152, 364, 385, 1830, 2883, 3545, 3588, 3675, 3842, 3873, 4025, 4056, 4394], 'deficiency': [136, 369, 491, 1713, 3567], 'was': [137, 155, 189, 370, 388, 422, 1848, 1857, 1882, 1913, 1925, 1939, 1951, 2044, 2113, 2126, 2147, 2167, 2292, 2337, 2351, 2390, 2436, 2464, 2484, 2530, 2540, 2577, 2627, 2649, 2660, 2701, 2718, 2730, 2763, 2788, 2825, 2837, 2994, 3003, 3028, 3103, 3118, 3126, 3289, 3332, 3352, 3369, 3377, 3414, 3452, 3516, 3548, 3591, 3623, 3822, 3876, 3930, 3968, 4028, 4112, 4199, 4215, 4246, 4301, 4317, 4335], 'blocked': [138, 157, 371, 390, 3550, 3847, 4158], 'actinomycin': [140, 373, 3537], 'D': [141, 374, 3388, 3538, 4373], 'cycloheximide,': [143, 376, 1965], 'consistent': [144, 377, 3043, 3624, 4097], 'with': [145, 229, 378, 462, 1511, 1551, 1728, 1994, 2024, 2029, 2051, 2129, 2187, 2339, 2358, 2365, 2380, 2399, 2460, 2665, 2790, 2808, 3044, 3217, 3231, 3248, 3295, 3403, 3418, 3470, 3536, 3625, 3649, 4085, 4098, 4154, 4187, 4254, 4341], 'transcriptionally': [147, 380, 1617], 'induced': [148, 381, 3517], 'or': [149, 382, 529, 2194, 2364, 2760, 3120, 3274, 3345, 3518, 3539, 3608, 3922, 4037, 4444], 'regulated': [150, 383], 'transporter.': [151, 185, 384, 418, 4412], 'completely': [156, 389, 3549, 3846, 4074, 4157], 'unlabeled': [159, 392], 'Fe3+': [160, 393, 3227, 3614, 3739, 3790, 4401], 'other': [163, 396, 1707, 1742, 1973, 3886, 3923], 'trivalent': [164, 183, 397, 416, 1841, 4091, 4410, 4449, 4467], 'cations': [165, 398, 4468], 'including': [166, 399, 625, 1014, 4033], 'Al3+,': [167, 400, 4456], 'Ga3+,': [168, 401], 'Cr3+,': [170, 403, 4457], 'but': [171, 404, 1063, 3033, 3108, 3421, 3647, 3845, 3879, 3967], 'not': [172, 405, 993, 1141, 2950, 3034, 3104, 3279, 3378, 3422, 3496, 3598, 3617, 3648, 3799, 3881, 4019, 4043, 4052, 4167, 4286, 4430], 'divalent': [174, 407, 4031], 'cations.': [175, 408], 'These': [176, 409, 1499, 3461, 3869], 'results': [177, 410, 1827, 3242, 3462, 3650, 3857, 3870, 3981, 4414], 'indicate': [178, 411], 'utilizes': [181, 414, 1838], 'cation-specific': [184, 417, 1842], 'as': [194, 427, 485, 917, 1884, 2183, 2404, 2472, 2544, 2677, 3412, 3578, 3580, 3613, 4348], 'ineffectiveness': [198, 431], 'two': [200, 433, 924, 1145, 2210, 4380], 'ferroxidase-deficient': [201, 434], 'preparations,': [203, 436], 'copper-deficient': [204, 437], 'thiomolybdate-treated': [207, 440, 4188], 'Cp.': [208, 441, 1721, 1890, 3129, 3733, 4105, 4116], 'propose': [210, 443], 'model': [212, 445, 693], 'reduction': [216, 449], 'subsequent': [218, 451], 're-oxidation': [219, 452], 'are': [222, 455, 1140, 1494, 1501, 2899, 3215, 3798], 'essential': [223, 456], 'an': [225, 458, 476, 691, 722, 1716, 1745, 1860, 2514, 2533, 2783, 2925, 3558, 4202, 4304], 'pathway': [228, 461, 684, 724, 813, 1598, 3821, 4177], 'ion': [231, 464, 2817], 'specificity.': [232, 465], 'Iron': [466, 490, 581, 644], 'important': [468, 692, 1717, 1746], 'many': [470, 1011], 'biological': [471], 'processes': [472, 3730, 3889], 'because': [473, 481], 'it': [474, 482, 1088, 4334, 4446], 'ideal': [477], 'O2': [478], 'carrier': [479], 'can': [483, 498], 'function': [484, 1056, 1719], 'protein-bound': [487], 'redox': [488], 'element.': [489], 'common': [493, 823], 'worldwide': [494], 'infants': [497], 'cause': [499], 'severe': [500, 778], 'neurological': [501], 'deficit': [502], '(1DeMaeyer': [503], 'E.': [504, 876, 886, 970, 2687, 3759, 4139], 'Adiels-Tegman': [505], 'M.': [506, 785, 1041, 1114, 1165, 1224, 2587, 2745, 2905, 3658, 3714, 3912, 3914], 'World': [507], 'Health': [508, 584, 647], 'Stat.': [509], 'Quart.': [510], '1985;': [511, 3917], '38:': [512], '302-316PubMed': [513], 'Google': [514, 612, 751, 805, 913, 988, 1034, 1052, 1083, 1135, 1175, 1202, 1232, 1246, 1288, 1314, 1362, 1412, 1437, 1464, 1491, 1531, 1612, 1637, 1671, 1696, 1780, 1793, 1806, 2080, 2433, 2572, 2600, 2697, 2755, 2872, 2916, 2945, 2970, 3062, 3208, 3645, 3669, 3725, 3770, 3818, 3920, 3957, 4012, 4149, 4282], 'Scholar).': [515, 613, 655, 752, 806, 989, 1136, 1203, 1247, 1363, 1532, 1613, 1697, 1807, 2081, 2434, 2573, 2698, 2756, 2873, 2917, 3063, 3209, 3771, 3958, 4150, 4283], 'contrast,': [517], 'excess': [520, 2055, 2497, 2622, 4050], 'needs': [523], 'toxic': [525], 'dietary': [527], 'overload': [528], 'hereditary': [530, 538], 'hemochromatosis': [531, 779], '(HH)': [532], '1The': [533], 'abbreviations': [534], 'used': [535, 2887, 3931], 'are:': [536], 'HH,': [537, 820, 922], 'hemochromatosis;': [539], 'Cp,': [540, 3107], 'ceruloplasmin;': [541], 'GSH,': [542], 'reduced': [543, 1962, 2471], 'glutathione;': [544], 'Nramp,': [545], 'natural': [546], 'resistance-associated': [547], 'macrophage': [548], 'protein;': [549], 'NTA,': [550], 'nitrilotriacetic': [551, 1966], 'acid;': [552], 'PAGE,': [553], 'polyacrylamdie': [554], 'gel': [555, 2336, 2771, 3450], 'electrophoresis;': [556], 'MOPS,': [557, 2522], '4-morpholinepropanesulfonic': [558], 'acid.': [559], 'leads': [560], 'deposition': [564], 'injury': [566], '(2Britton': [567], 'R.S.': [568, 1039, 1220, 2903], 'Tavill': [569, 599], 'A.S.': [570, 600], 'Bacon': [571, 901], 'B.R.': [572, 594, 902], 'Brock': [573, 636], 'J.H.': [574, 635, 637], 'Halliday': [575, 638], 'J.W.': [576, 639], 'Pippard': [577, 640], 'M.J.': [578, 641], 'Powell': [579, 642], 'L.W.': [580, 643], 'Metabolism': [582, 645], '&': [585, 648], 'Disease.': [586, 649], 'W.': [587, 650, 843, 2070], 'B.': [588, 651, 1118, 1180], 'Saunders,': [589, 652], 'London1994:': [590, 653], '311-351Google': [591], 'Scholar,': [592, 1176, 1233, 1413, 1438, 1672, 1781, 1794], '3Bacon': [593], 'Brittenham': [595], 'G.M.': [596], 'Park': [597], 'C.H.': [598], 'Ann.': [601], 'N.': [602, 882, 966], 'Y.': [603, 1184, 1276, 1519], 'Acad.': [604, 794, 977, 1351, 1453, 1769, 3946], 'Sci.': [605, 795, 978, 1352, 1454, 1770, 3947], '1988;': [606, 3908], '526:': [607], '155-163Crossref': [608], 'PubMed': [609, 748, 802, 910, 985, 1033, 1051, 1082, 1134, 1172, 1199, 1229, 1243, 1285, 1311, 1359, 1409, 1434, 1461, 1488, 1528, 1609, 1634, 1668, 1693, 1777, 1790, 1803, 2077, 2430, 2569, 2599, 2694, 2752, 2869, 2915, 2942, 2969, 3059, 3205, 3642, 3666, 3722, 3769, 3817, 3954, 4011, 4146, 4279], 'Scopus': [610, 749, 803, 911, 986, 1173, 1200, 1230, 1244, 1286, 1312, 1360, 1410, 1435, 1462, 1489, 1529, 1610, 1635, 1669, 1694, 1778, 1791, 1804, 2078, 2431, 2570, 2695, 2753, 2870, 2943, 3060, 3206, 3643, 3667, 3723, 3955, 4147, 4280], '(11)': [611], 'Alterations': [614], 'pools': [617], 'been': [619, 686, 1008, 1152], 'implicated': [620], 'diverse': [622], 'human': [623, 1541, 1846, 1957, 2888, 3015], 'diseases,': [624], 'neurodegenerative': [626], 'disease,': [627], 'aging,': [628], 'atherosclerosis,': [629], 'cancer,': [630], 'microbial': [632], 'infection': [633], '(4Brock': [634], '353-389Google': [654], 'precise': [657, 2975], 'intracellular': [663, 3285, 3362, 3488], 'several': [674], 'independent': [675], 'transport': [678, 1843, 4027, 4176], 'pathways.': [679], 'transferrin-mediated': [681, 3974], 'extensively': [687], 'studied': [688], 'understanding': [695], 'recycling,': [697], 'receptor-mediated': [698, 3793, 3887, 3934, 4016], 'endocytosis': [699, 3893, 3935, 4017], 'pathway,': [703], 'diferric': [704], 'endocytosed': [707], 'cell': [710, 720, 1205, 1509, 1578, 3159, 3350, 4026, 4407], 'surface': [711, 1206, 1325, 3160], 'receptor': [713, 732, 759, 944, 997, 1920, 3865], 'delivered': [717], 'endosomal': [723], 'accompanied': [725], 'recycling': [727], '(5De': [733], 'Jong': [734], 'G.': [735, 2411, 2550, 2589, 2685, 3993, 4137, 4260], 'Van': [736, 739, 1389, 1648, 3191, 3989], 'Dijk': [737], 'J.P.': [738, 787], 'Eijk': [740], 'H.G.': [741], 'Clin.': [742, 1798, 2072, 2746], 'Chim.': [743, 2747], 'Acta.': [744, 2748], '1990;': [745, 2074, 2593], '190:': [746], '1-46Crossref': [747], '(340)': [750], 'physiological': [754, 1718], 'significance': [755], 'presence': [764, 2193, 3474, 4071, 4345], 'virtually': [766], 'all': [767, 932, 3328], 'fact': [773], 'hypotransferrinemic': [775], 'animals': [776], 'develop': [777], '(6Craven': [780], 'C.M.': [781], 'Alexander': [782], 'J.': [783, 791, 1024, 1042, 1068, 1073, 1125, 1161, 1166, 1237, 1239, 1299, 1300, 1401, 1422, 1423, 1476, 1477, 1660, 1681, 1682, 1783, 1796, 1797, 2071, 2419, 2558, 2590, 2688, 2906, 2960, 3200, 3760, 3808, 3903, 3991, 4002, 4140, 4268], 'Eldridge': [784], 'Kushner': [786], 'Bernstein': [788], 'S.': [789, 797, 980, 1163, 1190, 1354, 1383, 1397, 1456, 1471, 1656, 1772, 2414, 2553, 3660, 3716, 3755, 3949, 4263], 'Kaplan': [790, 1064, 1236, 1298, 1400, 1421, 1475, 1659, 1680], 'Proc.': [792, 975, 1349, 1451, 1767, 3944], 'Natl.': [793, 976, 1350, 1452, 1768, 3945], 'U.': [796, 979, 1353, 1455, 1771, 3948], 'A.': [798, 841, 849, 858, 960, 981, 1072, 1122, 1280, 1340, 1355, 1391, 1444, 1457, 1523, 1650, 1760, 1773, 2585, 3950, 3999], '1987;': [799], '84:': [800], '3457-3461Crossref': [801], '(224)': [804], 'central': [808], 'importance': [809], 'recent': [817, 1258, 1723], 'most': [822], 'inherited': [824], 'disease': [825], 'people': [827], 'northern': [829], 'European': [830], 'descent.': [831], 'Positional': [832], 'cloning': [833, 1375], 'Feder': [836], 'et': [837, 1065, 2408, 2681, 3653, 3709], 'al.(7Feder': [838], 'J.N.': [839, 956], 'Gnirke': [840], 'Thomas': [842], 'Tsuchihashi': [844, 967], 'Z.': [845, 968], 'Ruddy': [846], 'D.A.': [847, 3757], 'Basava': [848], 'Dormishian': [850], 'F.': [851], 'Domingo': [852], 'Jr.,': [853], 'R.': [854, 1272, 1442, 1515, 1758, 2068, 3937], 'Ellis': [855], 'M.C.': [856, 3941], 'Fullan': [857], 'Hinton': [859], 'L.M.': [860], 'Jones': [861], 'N.L.': [862], 'Kimmel': [863], 'B.E.': [864], 'Kronmal': [865], 'G.S.': [866], 'Lauer': [867], 'P.': [868], 'Lee': [869, 961], 'V.K.': [870, 962], 'Loeb': [871], 'D.B.': [872], 'Mapa': [873], 'F.A.': [874], 'McClelland': [875], 'Meyer': [877], 'N.C.': [878], 'Mintier': [879], 'G.A.': [880], 'Moeller': [881], 'Moore': [883], 'T.': [884, 1446, 1448, 1762, 1764], 'Morikang': [885], 'Prass': [887], 'C.E.': [888], 'Quintana': [889], 'L.': [890, 1395, 1654, 2418, 2557, 4267], 'Starnes': [891], 'S.M.': [892], 'Schatzman': [893, 973], 'R.C.': [894, 974], 'Brunke': [895], 'K.J.': [896], 'Drayna': [897], 'D.T.': [898], 'Risch': [899], 'N.J.': [900], 'Wolff': [903], 'R.K.': [904], 'Nat.': [905], 'Genet.': [906], '1996;': [907, 1282, 1525, 1787, 1800, 2422, 2561, 4271], '13:': [908, 2750, 3918], '399-408Crossref': [909], '(3366)': [912], 'Scholar)': [914, 1035, 1053, 1084, 1289, 1465, 2601, 2971, 3670, 3726, 3921, 4013], 'identified': [915, 1154], 'HFE': [916, 925, 936, 991], 'candidate': [919], 'gene': [920, 937, 1730], 'mutations': [926], 'account': [927], 'about': [929, 1880, 2987, 2996, 3005, 3077, 3081, 3314, 3443, 4356, 4363], '80–85%': [930, 1881], 'HH.': [933], 'normal': [935, 3250, 3276], 'product,': [938], 'binding': [940, 3154, 3749], 'lowering': [946], 'transferrin,': [950, 2954], 'down-regulates': [951], 'intestinal': [952], 'absorption': [954], '(8Feder': [955], 'Penny': [957], 'D.M.': [958, 1023, 1399, 1416, 1658, 1675], 'Irrinki': [959], 'Lebrón': [963], 'J.A.': [964, 1159], 'Watson': [965], 'Sigal': [969], 'Bjorkman': [971], 'P.J.': [972, 1124], '1998;': [982, 1606, 1631, 2866, 2939, 3056, 3639], '95:': [983], '1472-1477Crossref': [984], '(731)': [987], 'Mutant': [990], 'does': [992], 'bind': [994, 4126], 'lacks': [999], 'suppressor': [1001], 'activity.': [1002], 'Transferrin-independent': [1003, 1137], 'described': [1009, 2405, 2545, 2678], '(9Randell': [1016], 'E.W.': [1017], 'Parkes': [1018], 'J.G.': [1019], 'Olivieri': [1020], 'N.F.': [1021], 'Templeton': [1022], 'Biol.': [1025, 1043, 1074, 1126, 1168, 1301, 1424, 1478, 1683, 2420, 2559, 2591, 2907, 2961, 3761, 3809, 4003, 4269], 'Chem.': [1026, 1044, 1075, 1127, 1302, 1425, 1479, 1684, 2421, 2560, 2592, 2908, 2962, 3762, 3810, 4004, 4270], '1994;': [1027, 1226, 1240, 1403, 1662], '269:': [1028], '16046-16053Abstract': [1029], 'Full': [1030, 1048, 1079, 1131, 1306, 1308, 1406, 1429, 1431, 1483, 1485, 1665, 1688, 1690, 2425, 2427, 2564, 2566, 2596, 2912, 2966, 3766, 3814, 4008, 4274, 4276], 'Text': [1031, 1049, 1080, 1132, 1307, 1309, 1407, 1430, 1432, 1484, 1486, 1666, 1689, 1691, 2426, 2428, 2565, 2567, 2597, 2913, 2967, 3767, 3815, 4009, 4275, 4277], 'PDF': [1032, 1050, 1081, 1133, 1310, 1408, 1433, 1487, 1667, 1692, 2429, 2568, 2598, 2914, 2968, 3768, 3816, 4010, 4278], '(10Inman': [1038, 2902], 'Wessling-Resnick': [1040, 1164, 1223, 2904], '1993;': [1045, 2909], '268:': [1046, 2910], '8521-8528Abstract': [1047, 2911], 'transferrin-independent': [1059, 1216], 'system': [1060], 'unknown,': [1062], 'al.': [1066, 2409, 2548, 3654, 3710], '(11Kaplan': [1067], 'Jordan': [1069], 'I.': [1070, 1235], 'Sturrock': [1071], '1991;': [1076], '266:': [1077], '2997-3004Abstract': [1078], 'proposed': [1086], 'clears': [1089], 'potentially': [1090], 'toxic,': [1091], 'chelates': [1096, 1102], '(e.g.': [1097, 3161], 'bound': [1099, 2157, 3353], 'iron).': [1100], 'Such': [1101], 'accumulate': [1103], 'very': [1106, 3970], 'large': [1107], 'extent': [1108], 'HH': [1110], 'patient': [1111], 'plasma': [1112, 3016], '(12Grootveld': [1113], 'Bell': [1115], 'J.D.': [1116], 'Halliwell': [1117], 'Aruoma': [1119], 'O.I.': [1120], 'Bomford': [1121], 'Sadler': [1123], '1989;': [1128], '264:': [1129], '4417-4422Abstract': [1130], 'well': [1142, 2900, 3579], 'understood;': [1143], 'however,': [1144], 'putative': [1146, 3896], 'transporters,': [1147], 'DCT1': [1148], 'SFT,': [1150], 'mammalian': [1156], '(13Gutierrez': [1158], 'Yu': [1160], 'Rivera': [1162], 'Cell': [1167], '1997;': [1169, 1196, 1303, 1480, 3663, 3719], '139:': [1170], '895-905Crossref': [1171], '(79)': [1174], '14Gunshin': [1177], 'H.': [1178], 'Mackenzie': [1179], 'Berger': [1181], 'U.V.': [1182], 'Gunshin': [1183], 'Romero': [1185], 'M.F.': [1186], 'Boron': [1187], 'W.F.': [1188], 'Nussberger': [1189], 'Gollan': [1191], 'J.L.': [1192], 'Hediger': [1193], 'M.A.': [1194], 'Nature.': [1195], '388:': [1197], '482-488Crossref': [1198], '(2679)': [1201], 'ferrireductase': [1207], 'also': [1209, 1333, 4415], 'active': [1210, 3101, 3487], 'may': [1212, 1714, 3685, 3727], 'be': [1213, 1715, 3529, 3686], '(15Inman': [1219], 'Coughlan': [1221], 'M.M.': [1222], 'Biochemistry.': [1225], '33:': [1227], '11850-11857Crossref': [1228], '(72)': [1231], '16Jordan': [1234], 'Biochem.': [1238, 2690, 4142], '302:': [1241], '875-879Crossref': [1242], '(82)': [1245], 'Important': [1248], 'insights': [1249], 'into': [1250, 2300, 3142, 3367, 3434, 3484, 4289, 4405], 'eukaryotic': [1251], 'come': [1256], 'genetic': [1260], 'studies.': [1261], 'Two': [1262], 'transporters': [1264, 1513, 3102], '(or': [1265, 1328, 2953, 3561], '"permeases"),': [1266], 'Ftr1p': [1267], 'Saccharomyces': [1269], 'cerevisiae': [1270, 1384], '(17Stearman': [1271, 1514], 'Yuan': [1273, 1516], 'D.S.': [1274, 1440, 1517, 1756], 'Yamaguchi-Iwai': [1275, 1518], 'Klausner': [1277, 1347, 1449, 1520, 1765], 'R.D.': [1278, 1348, 1450, 1521, 1766, 3988], 'Dancis': [1279, 1443, 1522, 1759], 'Science.': [1281, 1524, 1605, 1630, 1786, 2865, 2938, 3055, 3638], '271:': [1283, 1526, 1788, 2423, 2562, 4272], '1552-1557Crossref': [1284, 1527], '(582)': [1287, 1530], 'Fip1p': [1293], 'Schizosaccharomyces': [1295], 'pombe(18Askwith': [1296], 'C.': [1297, 1386, 1474, 1645, 3995], '272:': [1304, 1481], '401-405Abstract': [1305, 1482], '(125)': [1313, 1490], 'Scholar),': [1315, 1492, 1638, 2946, 3646, 3819], 'yeast.': [1323], 'ferrireductase,': [1326], 'Fre1p': [1327], 'homologue': [1330, 1468], 'Fre2p),': [1331], 'necessary': [1334, 4392], '(19Dancis': [1339], 'Roman': [1341], 'D.G.': [1342], 'Anderson': [1343], 'G.J.': [1344], 'Hinnebusch': [1345], 'A.G.': [1346], '1992;': [1356], '89:': [1357], '3869-3873Crossref': [1358], '(282)': [1361], 'requirement': [1365, 4100], 'genes': [1377], 'encoding': [1378], 'copper-containing': [1379], 'proteins,': [1380, 2302], 'Fet3p': [1381, 1533, 1566, 1640], '(20Askwith': [1385, 1644], 'Eide': [1387, 1419, 1646, 1678], 'D.': [1388, 1420, 1647, 1679], 'Ho': [1390, 1649], 'Bernard': [1392, 1651], 'P.S.': [1393, 1652], 'Li': [1394, 1653], 'Davis-Kaplan': [1396, 1655], 'Sipe': [1398, 1657], 'Cell.': [1402, 1661], '76:': [1404, 1663], '403-410Abstract': [1405, 1664], '(588)': [1411, 1670], '21De': [1414, 1673], 'Silva': [1415, 1674], 'Askwith': [1417, 1676], 'C.C.': [1418, 1677], '1995;': [1426, 1458, 1685, 1774, 3202], '270:': [1427, 1686], '1098-1101Abstract': [1428, 1687], '(208)': [1436, 1695], '22Yuan': [1439], 'Stearman': [1441, 1757], 'Dunn': [1445, 1761], 'Beeler': [1447, 1763], '92:': [1459, 1775], '2632-2636Crossref': [1460, 1776], '(394)': [1463, 1779], 'Fio1p': [1469], 'pombe': [1472], '(18Askwith': [1473], 'proteins': [1500], 'membrane-spanning,': [1502], 'multicopper': [1503], 'interact': [1506], 'at': [1507, 2106, 2203, 2214, 2243, 2255, 2272, 2279, 2385, 2438, 2724, 2802, 2840, 2995, 3004, 4046], 'membrane': [1510, 2288, 2309, 3302, 3382], '(and': [1534, 1705, 3323, 4039], 'Fio1p)': [1535], 'limited': [1537], 'sequence': [1538], 'homology': [1539], '(Cp),': [1543], 'like': [1545], 'protein': [1550, 2331, 2381, 3368, 3376, 3446, 4229, 4316], 'catalyzes': [1556], 'ferrous': [1559, 2792, 2823], 'ferric': [1561], 'ion.': [1562], 'similarities': [1564], 'between': [1565], 'suggest': [1569, 4416], 'possible': [1571, 3775], 'latter': [1575, 4095], '(23Mukhopadhyay': [1599, 1624, 2859, 2932, 3049, 3632], 'C.K.': [1600, 1625, 2860, 2933, 3050, 3633], 'Attieh': [1601, 1626, 2861, 2934, 3051, 3634], 'Z.K.': [1602, 1627, 2862, 2935, 3052, 3635], 'Fox': [1603, 1628, 2863, 2936, 3053, 3636], 'P.L.': [1604, 1629, 2864, 2937, 3054, 3637], '279:': [1607, 1632, 2867, 2940, 3057, 3640], '714-717Crossref': [1608, 1633, 2868, 2941, 3058, 3641], '(179)': [1611, 1636, 2871, 2944, 3061, 3644], 'Furthermore,': [1614], 'deprivation': [1616], 'induces': [1618], 'synthesis': [1620, 1641], 'Thus': [1698], 'maintenance': [1699], 'homeostasis': [1702, 1752], 'liver': [1704], 'possibly': [1706], 'tissues)': [1708], 'during': [1709], 'periods': [1710], 'observation': [1724], '"aceruloplasminemia"': [1726], 'defects': [1731], 'massive': [1733], 'liver,': [1737], 'pancreas,': [1738], 'brain,': [1739], 'retina,': [1740], 'tissues': [1743], 'indicates': [1744], 'vivo': [1754], '(22Yuan': [1755], '24Kaplan': [1782], "O'Halloran": [1784], 'T.V.': [1785], '1510-1512Crossref': [1789], '(124)': [1792], '25Kaplan': [1795], 'Invest.': [1799, 2073], '98:': [1801], '3-4Crossref': [1802], '(4)': [1805], 'report': [1810], 'investigate': [1812], 'erythroleukemic': [1823, 1980, 2889], 'Our': [1826], 'show': [1828, 3136, 3871], 'requires': [1833], 'novel,': [1840], 'Purified': [1845], 'obtained': [1849, 3247, 3859, 3983], 'Calbiochem': [1851], '(La': [1852], 'Jolla,': [1853], 'CA).': [1854], 'homogeneity': [1856], 'verified': [1858, 2531], 'absorbance': [1861], 'ratio': [1862], '(610': [1863], 'nm/280': [1864], 'nm)': [1865], 'higher': [1866], 'than': [1867, 2164, 3012], '0.045,': [1868], 'SDS-PAGE': [1871, 2316, 3372, 4218, 4320], 'Coomassie': [1873, 2340, 3455, 4221, 4322], 'Blue': [1874, 3456, 4222, 4323], 'staining.': [1875], 'Densitometric': [1876], 'analysis': [1877, 2878, 4219], 'showed': [1878], 'present': [1883], 'intact,': [1886], '132-kDa': [1887, 4227], 'form': [1888], '55FeCl3': [1891, 2048], '(20': [1892, 2304], 'mCi/mg),': [1893, 1896], '59FeCl3': [1894], '(19.22': [1895], 'and51CrCl3': [1897], '(789': [1898], 'mCi/mg)': [1899], 'were': [1900, 1944, 1976, 1986, 2001, 2021, 2091, 2185, 2208, 2251, 2264, 2313, 2470, 2499, 3133, 3293, 3299, 3534, 3584, 3858, 3890, 3982], 'NEN': [1902], 'Life': [1903], 'Science': [1904], 'Products': [1905], 'Inc.': [1906, 1929], '(Boston,': [1907], 'MA).': [1908, 1948], 'Rabbit': [1909], 'anti-human': [1910, 1918, 1936, 2360, 2370, 3830, 3863], 'apotransferrin': [1911, 3753], 'antibody': [1912, 1923, 2368, 3426, 3832, 3838, 3866], 'Accurate': [1915], '(Westbury,': [1916], 'NY),': [1917], 'mouse': [1921], 'monoclonal': [1922, 3862], '(H68.4)': [1924], 'Zymed': [1927], 'Laboratories': [1928], '(South': [1930], 'San': [1931], 'Francisco,': [1932], 'CA),': [1933, 2378], 'rabbit': [1935, 2359, 3828], 'ferritin': [1937, 2346, 2361, 3404, 3413, 3435], 'IgG': [1938, 2362], 'Boehringer-Mannheim.': [1941], 'Nitrocellulose': [1942], 'filters': [1943], 'Millipore': [1946], '(Bedford,': [1947], 'Ammonium': [1949], 'tetrathiomolybdate': [1950, 2667, 4156], 'Sigma-Aldrich': [1953], '(Milwaukee,': [1954], 'WI),': [1955], 'apotransferrin,': [1958], 'horse': [1959], 'spleen': [1960], 'apoferritin,': [1961], 'glutathione': [1963], '(GSH),': [1964], 'acid': [1967], '(NTA),': [1968], 'bathophenanthroline': [1969, 2012], 'disulfonic': [1970], 'acid,': [1971], 'assay': [1974, 2536, 4204, 4306], 'reagents': [1975], 'Sigma.': [1978], 'Human': [1979], '(ATCC,': [1983], 'Rockville,': [1984], 'MA)': [1985], 'grown': [1987], 'iron-free': [1989], 'RPMI': [1990, 2008, 2030, 2060, 2100], '1640': [1991, 2009, 2031, 2061, 2101], 'medium': [1992, 2010, 2062, 2102, 3612], 'supplemented': [1993], '10%': [1995, 3344], 'fetal': [1996], 'bovine': [1997], 'serum.': [1998], 'made': [2002, 2179, 3438], 'resuspension': [2005], 'serum-free': [2007], 'containing': [2011, 2063, 2136, 2449, 2508, 2519, 3220, 3253], 'disulfonate': [2013, 3234], '(100': [2014], 'μm)': [2015, 2050, 2095, 2190, 2659], '4–8': [2017], 'h.': [2018, 2492, 2646, 2843], 'washed': [2022, 2127, 2209], 'twice': [2023, 2128], 'phosphate-buffered': [2025, 2655, 2712], 'saline': [2026], 'once': [2028], 'medium,': [2032], 'then': [2034, 2219, 2379, 2512, 2710], 'resuspended': [2035], 'same': [2038, 2708, 4062], 'medium.': [2039, 3836], 'solution': [2041, 3219, 3252], '55Fe-NTA': [2043, 3074], 'prepared': [2045, 2391, 2578, 4247], 'mixing': [2047], '(15–20': [2049], '4-fold': [2053], 'molar': [2054, 2621, 4049], 'NTA': [2057, 3609], 'colorless': [2059], '1': [2064, 2509, 2990, 3039, 3092, 3342, 3406, 3428, 3459, 3504, 3569], 'mm': [2065, 2134, 2223, 2228, 2443, 2451, 2505, 2521, 2524, 2635, 2639], 'ascorbate': [2066, 2452], '(26Teichmann': [2067], 'Stremmel': [2069], '86:': [2075], '2145-2153Crossref': [2076], '(85)': [2079], 'To': [2082, 2296, 2328, 3281, 3359, 3523, 3571, 4233, 4327, 4437], 'measure': [2083, 3694], '5': [2086, 2260, 2491, 2638, 3221, 3232], '×': [2087, 2216, 2257, 2274], '106': [2088], 'incubated': [2092, 2186, 2661, 2789, 3294, 4186], 'with55Fe-NTA': [2093], '(1.4': [2094, 2189], '0.5': [2097, 3082], 'ml': [2098, 2131], '20–30': [2104], 'min': [2105, 2202, 2278, 2664, 2801], '25': [2107, 2204], '°C.': [2108, 2205, 2245, 2281], 'An': [2109], 'aliquot': [2110], '(0.1': [2111, 2607], 'ml)': [2112], 'removed': [2114, 2252, 2500, 2650, 2702], 'applied': [2116], 'nitrocellulose': [2119], 'filter': [2120, 2125], 'subjected': [2121, 2314, 2764], 'vacuum.': [2123], '3': [2130], '150': [2133, 2523, 2634], 'NaCl': [2135], '10': [2137, 2277, 2450, 2997, 3254], 'μm': [2138, 3079, 3083, 3222, 3255], 'EDTA': [2139], '(to': [2140], 'remove': [2141, 3182], 'surface-bound': [2142, 3185], 'iron)': [2143], 'cell-associated': [2145], 'radioactivity': [2146, 3319, 3351], 'measured': [2148, 2293, 2731, 3173, 3268, 3320], 'liquid': [2150], 'scintillation': [2151], 'counting.': [2152], 'amount': [2154, 2926, 3123], 'after': [2158], '"zero': [2160], 'time"': [2161], 'incubation': [2162, 2354, 2807, 3835, 4340], '(less': [2163], '15': [2165], 's)': [2166], 'subtracted': [2168], 'experimental': [2170, 3689], 'measurements': [2171], 'correct': [2173], 'nonspecific': [2175, 2367, 3425], 'binding.': [2176], 'cells,': [2178, 2247, 2286, 3325], 'iron-sufficient': [2180, 3036, 3501], 'above,': [2184], '59Fe-NTA': [2188], 'absence': [2195, 4296], '(30': [2198], 'μg/ml)': [2199], '20': [2201, 2222, 2663], 'times': [2211], 'centrifugation': [2213, 2254, 2271], '16,000': [2215, 2273, 2386], 'g,': [2217], 'lysed': [2220], 'HEPES,': [2224], 'pH': [2225, 2675], '8.0,': [2226], '2': [2227, 3078, 3978], 'MgCl2,': [2229], '1%': [2230, 2769, 2809], 'aprotinin,': [2231], '200': [2233], 'μg/ml': [2234, 2998], 'leupeptin': [2235], 'repeated': [2237], 'passage': [2238], 'through': [2239], '27-gauge': [2241], 'needle': [2242], '0': [2244], 'Unbroken': [2246], 'nuclei,': [2248], 'debris': [2250], '2000': [2256], 'g': [2258, 2275], 'min.': [2261], 'Membrane': [2262], 'fragments': [2263], 'separated': [2265], 'cytosol-containing': [2268], 'fraction': [2269, 2350, 3340, 3383, 3394], '4': [2280, 2439, 2645, 4209, 4231, 4308], 'Radioactivity': [2282], 'intact': [2285, 3322], 'cytosol': [2290, 3304], 'fractions': [2291, 2312, 3305], 'γ-counting.': [2295], 'determine': [2297, 3572], 'incorporation': [2298, 3366, 3432], 'of59Fe': [2299, 3433], 'individual': [2301], 'aliquots': [2303], 'μg': [2305], 'protein)': [2307, 3564], 'cytosolic': [2311, 2349, 3339, 3393], '(6.5%)': [2317], 'under': [2318, 2401, 2453, 2777, 3356, 4256], 'nonreducing': [2319], 'conditions': [2320, 2403, 2455, 4258], 'autoradiography': [2322], '(Hyperfilm,': [2323], 'Amersham,': [2324], 'Buckinghamshire,': [2325], 'United': [2326], 'Kingdom).': [2327], 'evaluate': [2329], 'total': [2330, 3349], 'these': [2333, 3594], 'fractions,': [2334], 'stained': [2338], 'Blue.': [2341], 'control': [2344, 2976, 3131], 'experiment,': [2345], 'immunodepleted': [2352], '18': [2356], 'h': [2357], '(1:1000)': [2363], '(rabbit': [2369], 'Gqα': [2371], 'IgG;': [2372], 'Santa': [2373, 2376], 'Cruz': [2374], 'Biotechnology,': [2375], 'Cruz,': [2377], 'A-Sepharose,': [2382], 'centrifuged': [2384], '×g.': [2387], 'Apoceruloplasmin': [2388], '(apoCp)': [2389], 'removal': [2393, 4249], 'complexing': [2398, 4253], 'cyanide': [2400, 2481, 2498, 4255], 'reducing': [2402, 4257, 4350], 'Musci': [2407], '(27Musci': [2410, 2549, 4259], 'Di': [2412, 2551, 4261], 'Marco': [2413, 2552, 4262], 'Bellenchi': [2415, 2554, 4264], 'G.C.': [2416, 2555, 4265], 'Calabrese': [2417, 2556, 4266], '1972-1978Abstract': [2424, 2563, 4273], '(46)': [2432, 2571, 4281], 'dialyzed': [2437], '°C': [2440], 'against': [2441, 2503, 2517, 2654, 2706, 2711], '100': [2442, 2504], 'sodium': [2444, 2506, 3223], 'acetate': [2445, 2507, 2671, 2795], 'buffer': [2446, 2518, 2616, 2672, 2796], '(pH': [2447, 2527, 2617, 2642, 2797], '5.9)': [2448], 'anaerobic': [2454], 'achieved': [2456], 'continuous': [2458], 'bubbling': [2459], 'N2': [2461], 'gas.': [2462], 'Dialysis': [2463], 'continued': [2465, 2489], 'until': [2466], '"blue"': [2468], 'coppers': [2469], 'complete': [2475, 4377], 'decolorization': [2476], 'sample.': [2479], 'Potassium': [2480], '(50': [2482], 'mm)': [2483, 2608, 2612, 2669], 'added': [2485, 2628, 4045], 'dialysis': [2488, 2502, 2516, 2653, 2704], 'copper-cyanide': [2494], 'complex': [2495, 2576, 2626], 'mmcysteine,': [2510], 'overnight': [2515, 2652, 2705], '50': [2520, 2632], 'potassium': [2525, 2636, 2810], 'chloride': [2526, 2641, 3986], '7.0).': [2528, 2618], 'Inactivation': [2529], '"in-gel"': [2534], '(see': [2537], 'below).': [2538], 'Holoceruloplasmin': [2539], 'reconstituted': [2541, 4336, 4353], 'apoCp': [2543, 2630, 4214, 4245, 4298], 'Musciet': [2547], 'Cu1+-glutathione': [2575], 'immediately': [2579], 'before': [2580], 'use': [2581], '(28Ciriolo': [2582], 'M.R.': [2583], 'Desideri': [2584], 'Paci': [2586], 'Rotilio': [2588], '265:': [2594], '11030-11034Abstract': [2595], 'addition': [2603, 3605, 3825, 4180], 'sulfate': [2606, 2793], 'GSH': [2610, 4347], '(0.3': [2611], '0.1': [2614, 2813], 'mphosphate': [2615], '7-fold': [2620], 'Cu1+-GSH': [2625], 'mmMOPS,': [2633], 'chloride,': [2637], 'magnesium': [2640], '7.0)': [2643], 'Unbound': [2647], 'saline.': [2656, 2713], '(7.61': [2658], 'ammonium': [2666, 3985, 4155], '(1.52': [2668], '(320': [2673], 'mm,': [2674], '6.0)': [2676], 'Chidambaram': [2680], 'al.(29Chidambaram': [2682], 'M.V.': [2683, 4135], 'Barnes': [2684, 4136], 'Frieden': [2686, 3758, 4138], 'Inorg.': [2689, 4141], '1984;': [2691, 4143], '22:': [2692, 4144], '231-240Crossref': [2693, 4145], '(45)': [2696, 4148], 'Excess': [2699], 'thiomolybdate': [2700, 2717, 4124, 4197], 'buffer,': [2709], 'Removal': [2714], 'unreacted': [2716], 'monitored': [2719], 'monitoring': [2721], 'optical': [2722], 'density': [2723], '470': [2725], 'nm.': [2726], 'modification': [2734], 'method': [2737], 'Schen': [2739], 'Rabinovitz': [2741, 2744], '(30Schen': [2742], 'R.J.': [2743], '1966;': [2749, 3763], '537-538Crossref': [2751], '(14)': [2754], 'brief,': [2758], 'modified': [2761], 'electrophoresis': [2766], 'on': [2767, 3699, 3964], 'agarose': [2770], '(Seakem': [2772], 'Gold,': [2773], 'FMC,': [2774], 'Rockland,': [2775], 'ME)': [2776], 'nondenaturing': [2778], 'conditions.': [2779, 2978], 'After': [2780], 'transfer': [2781], 'Immobilon-P': [2784], 'membrane,': [2785], 'blot': [2787], '0.08%': [2791], '5.7),': [2798], '30': [2800, 3006], '37': [2803], '°C,': [2804], 'followed': [2805], 'ferrocyanide': [2811], 'n': [2814], 'HCl.': [2815], 'Ferric': [2816], '(formed': [2818], 'Cp-catalyzed': [2820], 'oxidation': [2821], 'ion)': [2824], 'detected': [2826, 3379], 'rapid': [2829], 'formation': [2830, 3785, 4427], '"Prussian': [2833], 'blue"': [2834], 'band': [2835, 3400, 3411], 'stable': [2838], 'least': [2841], '24': [2842], 'previously': [2846], 'For': [2874], 'more': [2876, 2974], 'detailed': [2877], 'since': [2892, 4178], 'transferrin-dependent': [2894], '-independent': [2896], 'pathways': [2898], 'characterized': [2901], 'Unlike': [2918], 'secrete': [2922, 2951, 3802], 'sufficient': [2927], 'promote': [2929], 'do': [2949], 'Ref.': [2955], '31Stein': [2956], 'B.S.': [2957, 3805], 'Sussman': [2958, 3806], 'H.H.': [2959, 3807], '1986;': [2963, 3811], '261:': [2964, 3812], '10319-10331Abstract': [2965, 3813], 'thereby': [2972], 'permitting': [2973], 'stimulated55Fe-NTA': [2980], '2–3-fold': [2988, 3262], '(Fig.': [2989, 3038, 3091, 3341, 3405, 3427, 3458, 3503, 3568, 3977, 4208, 4230, 4307, 4371], 'A).': [2991, 3854, 4164], 'Half-maximal': [2992], 'stimulation': [2993, 3022], 'maximal': [3001], 'μg/ml,': [3007], 'level': [3009], 'much': [3010], 'lower': [3011], 'unevoked': [3014], 'concentration': [3017], '300': [3019], 'μg/ml.': [3020], 'observed': [3029], 'B),': [3040], 'finding': [3042, 3492], 'decreasing': [3069], 'apparentK': [3071], 'm': [3072], 'iron,': [3084], 'without': [3085], 'changing': [3086], 'maximum': [3088], 'B).': [3093, 3979, 4210], 'This': [3094, 3239, 3621, 4077], 'result': [3095, 3622, 4078], 'indicated': [3096], 'number': [3099], 'altered': [3105], 'rather': [3109], 'transporter': [3115, 3514, 3560, 4084, 4435, 4441], 'increased': [3119, 3127, 3152, 3258, 3431], 'substrate': [3125, 4425], 'Several': [3130], 'experiments': [3132], 'done': [3134], 'entry': [3141, 3483], 'cell,': [3144], 'thus': [3146, 3774], 'exclude': [3147, 3882], 'possibility': [3149, 3884], 'extracellular': [3153], 'ferroxidase-dependent': [3163], 'soluble': [3166], 'insoluble': [3169], 'Fe3+).': [3170], 'First,': [3171], 'procedure': [3178, 3240], 'specifically': [3179, 3236], 'designed': [3180], 'complexes': [3183], '(32Glahn': [3187], 'R.P.': [3188], 'Gangloff': [3189], 'M.B.': [3190], 'Campen': [3192], 'D.R.': [3193], 'Miller': [3194], 'D.D.': [3195], 'Wien': [3196], 'E.M.': [3197], 'Norvell': [3198], 'W.A.': [3199], 'Nutr.': [3201], '125:': [3203], '1833-1840Crossref': [3204], '(47)': [3207], 'According': [3210], 'method,': [3213], 'rinsed': [3216], 'dithionite': [3224], 'reduce': [3226], 'μmbathophenanthroline': [3233], 'chelate': [3237], 'Fe2+.': [3238], 'gave': [3241], 'essentially': [3243, 3961], 'identical': [3244, 3856], 'those': [3246], 'rinse': [3251], 'EDTA;': [3256], 'when': [3267], 'either': [3270], '"reducing"': [3272], 'wash': [3273, 3277], '(data': [3278, 4018], 'shown).': [3280, 3868, 4020], 'verify': [3282, 3360, 4234], 'internalization,': [3284], 'membrane-bound': [3287], 'measured.': [3290, 3592], '59Fe-NTA,': [3296], 'lysed,': [3300], 'isolated': [3306], 'centrifugation.': [3308], 'experiment': [3311, 4063], '2-fold': [3316], 'increase': [3317, 3331, 3466, 3676], 'iron-deficient)': [3324], 'nearly': [3327], 'accounted': [3333], '59Fe': [3336], 'C);': [3343], 'less': [3346], 'membranes': [3355], 'any': [3357, 3385], 'condition.': [3358], 'localization': [3363], '59Fe,': [3365], 'determined': [3370], 'autoradiography.': [3374], 'Radiolabeled': [3375], 'samples': [3386], '(Fig.1,': [3387], 'E).': [3390, 4375], 'However,': [3391], 'exhibited': [3395], 'single': [3397], 'major': [3398], '59Fe-labeled': [3399], 'co-migrated': [3402], 'F).': [3407, 3429, 4326], 'Identification': [3408], 'the59Fe-labeled': [3410], 'confirmed': [3415, 4200, 4302], 'immunodepletion': [3417], 'anti-ferritin': [3419], 'IgG,': [3420], 'lysates': [3437], '90%;': [3444], 'equal': [3445], 'loading': [3447], 'lanes': [3451], 'stain': [3457], 'G).': [3460], 'demonstrate': [3463, 4329], 'associated': [3469], 'due': [3478, 3687], 'metabolically': [3486], 'pool.': [3490], 'did': [3495, 3597, 3616, 3880, 4051, 4166, 4285], 'stimulate': [3497], 'B)': [3505], 'factor': [3509, 3527], 'uptake,e.g.': [3512], 'itself,': [3515], 'activated': [3519], 'deficiency.': [3522], 'test': [3524, 4438], 'whether': [3525, 3573, 4439], 'must': [3528], 'synthesizedde': [3530], 'novo,': [3531], 'treated': [3535], 'cycloheximide': [3540], 'prior': [3541], 'depletion.': [3544], 'both': [3552], 'inhibitors': [3553], 'suggesting': [3554], 'transcriptional': [3555], 'up-regulation': [3556], 'regulatory': [3563], 'H).': [3570], 'efflux': [3577, 3679, 3705], 'influx,': [3581], 'preloaded': [3585], 'with55Fe-NTA,': [3586], 'release': [3590, 3601], 'Under': [3593], 'conditions,': [3595, 3690], 'enhance': [3599], '(Fig.1': [3602], 'I).': [3603], 'apo-transferrin': [3607], 'acceptors': [3615], 'alter': [3618], 'result.': [3620], 'our': [3626, 3692], 'previous': [3627], 'findings': [3628], 'Young': [3652, 3708], '(33Young': [3655, 3711], 'S.P.': [3656, 3712], 'Fahmy': [3657, 3713], 'Golding': [3659, 3715], 'FEBS': [3661, 3717], 'Lett.': [3662, 3718], '411:': [3664, 3720], '93-96Crossref': [3665, 3721], '(56)': [3668, 3724], 'reported': [3672], 'small': [3674], 'difference': [3684], 'e.g.': [3691, 3892], 'methods': [3693], 'effects': [3696], 'initial': [3700], 'rates': [3701], 'whereas': [3702], '18-h': [3704], 'intervals': [3706], 'reflect': [3728], 'equilibrium': [3729], 'shifted': [3731], 'thought': [3745], '(34Osaki': [3754], 'Johnson': [3756], '241:': [3764], '2746-2751Abstract': [3765], 'It': [3772], 'stimulating': [3783], 'Fe2-transferrin': [3787], 'delivers': [3789], 'endocytosis.': [3794], 'Although': [3795], 'known': [3800], '(31Stein': [3804], 'tested': [3823, 4216], 'polyclonal': [3829], 'only': [3839], 'slightly': [3840], 'inhibited': [3841, 4469], 'mediated': [3850], '(Fig.2': [3853], 'Essentially': [3855], '(not': [3867], 'receptor-independent,': [3878], 'endocytic': [3888], 'involved,': [3891], 'receptors': [3898], '(35Percival': [3899], 'S.S.': [3900], 'Harris': [3901], 'E.D.': [3902], 'Trace': [3904], 'Elem.': [3905], 'Exp.': [3906, 3915], 'Med.': [3907], '1:': [3909], '63-70Google': [3910], 'Scholar,36Kataoka': [3911], 'Tavassoli': [3913], 'Hematol.': [3916], '806-810PubMed': [3919], 'iron-protein': [3924], 'receptors.': [3925], 'lysosomatropic': [3927], 'inhibitor,': [3928], 'amantadine,': [3929], 'inhibit': [3933, 4015, 4130, 4168], '(37Schlegel': [3936], 'Dickson': [3938], 'R.B.': [3939], 'Willingham': [3940], 'Pastan': [3942], 'I.H.': [3943], '1982;': [3951], '79:': [3952], '2291-2295Crossref': [3953], '(130)': [3956], 'Amantadine': [3959], 'had': [3960], 'no': [3962], 'effect': [3963], 'Cp-stimulated55Fe-NTA': [3965], 'effective': [3971], 'inhibitor': [3972], 'Comparable': [3980], '(38Klausner': [3987], 'Renswoude': [3990], 'Ashwell': [3992], 'Kempf': [3994], 'Schechter': [3996], 'A.N.': [3997], 'Dean': [3998], 'Bridges': [4000], 'K.R.': [4001], '1983;': [4005], '258:': [4006], '4715-4724Abstract': [4007], 'cation': [4022, 4092, 4411], 'specificity': [4023, 4087], 'investigated.': [4029], 'Multiple': [4030], 'cations,': [4032, 4450], 'Ca2+,': [4034], 'Mg2+,': [4035], 'Cu2+,': [4036], 'Zn2+': [4038], 'Mn2+': [4040], 'Co2+,': [4042], 'shown),': [4044], '70-fold': [4048], 'substantially': [4053], 'compete': [4054, 4461], '(Fig.3).': [4059], '(FeCl3': [4065], 'plus': [4066], 'ascorbic': [4067], 'acid)': [4068], 'suppressed': [4075], 'suggests': [4079, 4398], 'absolute': [4086], 'Fe2+or': [4089], 'transporter;': [4093], 'examined': [4113, 4452], 'ferroxidase-defective': [4115, 4244, 4381], 'took': [4118], 'advantage': [4119], 'ability': [4122, 4454], 'irreversibly': [4129], '(29Chidambaram': [4134], 'Treatment': [4151], '(Fig.4': [4163, 4293, 4325], 'Thiomolybdate': [4165], 'inactivation': [4172, 4195], 'untreated': [4182], 'fully': [4190], 'restored': [4191], 'treatment': [4198], 'in-gel': [4203, 4305], 'integrity': [4212, 4313, 4331], 'staining': [4223, 4324], 'revealed': [4225], 'undegraded': [4228], 'C).': [4232], 'transport,': [4243], 'ApoCp': [4284], 'stimulate55Fe': [4287], 'influx': [4288], 'D).': [4294], 'E),': [4309], 'structural': [4312], 'further': [4328], 'apoCp,': [4333], 'holoCp': [4338], 'agent.': [4351], 'regained': [4355], '80%': [4357], '70%': [4364], 'enhancing': [4369], '4,': [4372], 'inactivity': [4378], 'forms': [4382], 'persuasive': [4386], 'evidence': [4387], 'product': [4402], 'transported': [4404], 'increasing': [4423], 'available': [4424], '(by': [4426], 'Fe3+),': [4429], 'activation': [4432], 'itself.': [4436], 'Fe3+-specific': [4443], 'if': [4445], 'transports': [4447], 'Ga3+': [4459], 'All': [4465], 'three': [4466], 'Cp-stimula': [4470]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2067672885', 'counts_by_year': [{'year': 2024, 'cited_by_count': 2}, {'year': 2023, 'cited_by_count': 4}, {'year': 2022, 'cited_by_count': 3}, {'year': 2021, 'cited_by_count': 2}, {'year': 2020, 'cited_by_count': 4}, {'year': 2019, 'cited_by_count': 3}, {'year': 2018, 'cited_by_count': 4}, {'year': 2017, 'cited_by_count': 4}, {'year': 2016, 'cited_by_count': 2}, {'year': 2015, 'cited_by_count': 2}, {'year': 2014, 'cited_by_count': 2}, {'year': 2013, 'cited_by_count': 9}, {'year': 2012, 'cited_by_count': 5}], 'updated_date': '2024-12-12T05:17:28.679956', 'created_date': '2016-06-24'}
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