Prostaglandin E2 Regulates Angiogenesis via Activation of Fibroblast Growth Factor Receptor-1

Name: Work Video:
Duration: 3 min 30 s
Federica Finetti; Raffaella Solito; Lucia Morbidelli; Antonio Giachetti; Marina Ziche; Sandra Donnini
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['https://openalex.org/W2358034211', 'https://openalex.org/W2357666146', 'https://openalex.org/W2350492422', 'https://openalex.org/W2269951243', 'https://openalex.org/W2095813250', 'https://openalex.org/W2076274660', 'https://openalex.org/W2061391711', 'https://openalex.org/W2029768316', 'https://openalex.org/W1972093241', 'https://openalex.org/W1035102213'], 'abstract_inverted_index': {'Prostaglandin': [0, 276, 561, 2852], 'E2': [1, 277, 562, 725, 2853], '(PGE2)': [2, 278], 'behaves': [3, 279], 'as': [4, 11, 13, 67, 87, 280, 287, 289, 343, 363, 593, 602, 630, 632, 990, 992, 1007, 1266, 1857, 1881, 1948, 1996, 2057, 2134, 2249, 2331, 2570, 2659, 2736, 3144, 3586, 3663, 4432, 4448, 4450, 4490, 4546, 4587, 4634, 4716, 4735, 4745, 4771, 4802, 4940, 5016, 5116, 5221, 5254, 5467, 5483, 5548], 'a': [5, 281, 555, 603, 792, 797, 1278, 1590, 2362, 2439, 2466, 2724, 3093, 3187, 3209, 3230, 3445, 3453, 3468, 3482, 3553, 3664, 3735, 3767, 3784, 3794, 3847, 3858, 4017, 4222, 4415, 4559, 4567, 4635, 4746, 4752, 4786, 4803, 4952, 5038, 5194, 5262, 5464, 5484], 'mitogen': [6, 282], 'in': [7, 14, 103, 142, 155, 171, 174, 224, 253, 269, 283, 290, 379, 418, 431, 447, 450, 500, 529, 545, 644, 1196, 1296, 1458, 1593, 1595, 1653, 1659, 1712, 1713, 1720, 1851, 1919, 2066, 2106, 2117, 2277, 2282, 2296, 2307, 2361, 2392, 2400, 2410, 2414, 2425, 2448, 2451, 2513, 2598, 2637, 2645, 2872, 2881, 3159, 3205, 3222, 3236, 3343, 3363, 3383, 3478, 3560, 3567, 3571, 3653, 3721, 3762, 3771, 3849, 3870, 4007, 4069, 4108, 4123, 4260, 4271, 4274, 4285, 4295, 4314, 4317, 4399, 4441, 4533, 4537, 4562, 4601, 4629, 4638, 4670, 4678, 4687, 4696, 4741, 4782, 4813, 5007, 5026, 5044, 5057, 5162, 5252, 5276, 5384, 5392, 5398, 5417, 5448, 5463, 5551, 5591], 'epithelial': [8, 284, 988], 'tumor': [9, 285, 559, 610, 646, 774, 820, 937, 946, 1213, 1255, 1307, 1360, 3654, 5601], 'cells': [10, 28, 108, 156, 271, 286, 304, 384, 432, 547, 737, 741, 1462, 1717, 1833, 1875, 1905, 1912, 1930, 2017, 2042, 2088, 2114, 2124, 2171, 2227, 2290, 2355, 2389, 2435, 2480, 2891, 3060, 3419, 3626, 3655, 3723, 3880, 4325, 4377, 4458, 4564, 4743, 5241, 5401], 'well': [12, 288, 631, 991, 1339], 'many': [15, 291, 987], 'other': [16, 292, 4712, 4867], 'cell': [17, 192, 219, 293, 468, 495, 1370, 2279, 2751, 3053, 3157, 3179, 3919, 4297, 4330, 4665, 4713, 5263], 'types.': [18, 294], 'We': [19, 295, 3462, 3471, 3746, 3898, 4063, 4127, 4642, 4932, 5630], 'investigated': [20, 296, 1825, 3614, 4014], 'the': [21, 34, 38, 43, 46, 60, 83, 110, 130, 145, 161, 180, 195, 201, 247, 264, 297, 310, 314, 319, 322, 336, 359, 386, 406, 421, 437, 456, 471, 477, 523, 540, 594, 637, 766, 785, 808, 844, 854, 859, 951, 981, 1034, 1247, 1291, 1331, 1346, 1349, 1352, 1357, 1656, 1723, 1807, 1826, 1853, 1863, 1992, 2046, 2050, 2078, 2101, 2175, 2226, 2239, 2319, 2386, 2388, 2420, 2434, 2696, 2700, 2737, 2745, 2880, 3032, 3046, 3065, 3099, 3102, 3111, 3148, 3151, 3160, 3227, 3243, 3252, 3266, 3281, 3293, 3324, 3364, 3378, 3384, 3402, 3405, 3473, 3511, 3522, 3525, 3532, 3537, 3587, 3602, 3607, 3621, 3731, 3749, 3754, 3763, 3803, 3820, 3823, 3828, 3834, 3850, 3866, 3876, 3901, 3956, 3973, 3983, 3994, 4008, 4047, 4066, 4105, 4119, 4132, 4177, 4215, 4229, 4233, 4256, 4290, 4310, 4333, 4344, 4391, 4408, 4418, 4422, 4513, 4527, 4556, 4581, 4608, 4612, 4617, 4625, 4630, 4639, 4647, 4653, 4658, 4709, 4730, 4783, 4806, 4814, 4846, 4870, 4948, 5045, 5054, 5058, 5069, 5131, 5137, 5143, 5164, 5172, 5184, 5188, 5200, 5217, 5227, 5249, 5257, 5358, 5381, 5393, 5407, 5414, 5422, 5457, 5459, 5557, 5570, 5580, 5596, 5612, 5632, 5641], 'actions': [22, 298, 3034, 5238], 'of': [23, 36, 45, 59, 74, 91, 133, 136, 147, 233, 249, 299, 312, 321, 335, 350, 367, 409, 412, 423, 509, 525, 558, 597, 605, 609, 624, 635, 640, 761, 800, 811, 955, 983, 1003, 1033, 1204, 1209, 1280, 1286, 1294, 1333, 1348, 1356, 1359, 1453, 1535, 1538, 1605, 1703, 1725, 1747, 1828, 1859, 1862, 1942, 2049, 2080, 2103, 2310, 2317, 2422, 2498, 2506, 2516, 2527, 2610, 2629, 2698, 2726, 2739, 2827, 2843, 2867, 2884, 3049, 3057, 3064, 3101, 3129, 3141, 3162, 3164, 3183, 3189, 3229, 3233, 3242, 3286, 3295, 3326, 3381, 3397, 3404, 3417, 3439, 3449, 3476, 3508, 3519, 3569, 3597, 3604, 3609, 3634, 3671, 3730, 3751, 3765, 3775, 3831, 3837, 3852, 3868, 3875, 3958, 3986, 4004, 4010, 4049, 4092, 4152, 4161, 4165, 4181, 4263, 4266, 4282, 4292, 4312, 4335, 4372, 4402, 4410, 4421, 4475, 4479, 4485, 4529, 4558, 4571, 4576, 4580, 4611, 4619, 4632, 4652, 4711, 4726, 4733, 4737, 4748, 4789, 4809, 4852, 4955, 5072, 5106, 5140, 5145, 5175, 5187, 5197, 5242, 5264, 5378, 5389, 5396, 5410, 5427, 5472, 5546, 5560, 5572, 5598, 5616, 5621, 5634], 'PGE2': [24, 54, 81, 113, 123, 217, 255, 300, 330, 357, 389, 399, 493, 531, 771, 776, 842, 940, 1205, 1250, 1281, 1334, 1366, 1448, 1750, 1829, 2052, 2159, 2304, 2379, 2507, 2868, 3037, 3050, 3076, 3096, 3107, 3135, 3194, 3199, 3225, 3244, 3360, 3373, 3391, 3415, 3509, 3563, 3600, 3616, 3637, 3646, 3718, 3733, 3790, 3810, 3886, 3904, 3959, 3968, 3987, 4027, 4041, 4076, 4248, 4288, 4381, 4411, 4444, 4540, 4604, 4633, 4706, 4738, 4750, 4766, 4810, 4831, 4840, 4945, 5006, 5029, 5176, 5359, 5397, 5435, 5605], 'on': [25, 301, 1272, 1335, 1351, 1728, 1830, 2085, 2358, 2879, 2888, 3028, 3038, 3753, 3918, 3988, 4412, 4520, 4544, 4763, 4936, 5236], 'microvascular': [26, 302, 578, 739, 1831, 1903, 3040], 'endothelial': [27, 31, 76, 107, 270, 303, 307, 352, 383, 546, 576, 579, 581, 736, 740, 743, 994, 1009, 1369, 1461, 1704, 1716, 1832, 1874, 1904, 1911, 2890, 3041, 3059, 3418, 3722, 3879, 4324, 4376, 4442, 4457, 4563, 4664, 4689, 4742, 4757, 5008, 5385, 5400, 5617], '(capillary': [29, 305], 'venular': [30, 106, 306, 382, 575, 735, 1873, 1910, 4323, 4375], 'cells)': [32, 308], 'with': [33, 100, 163, 309, 376, 439, 1924, 1932, 1991, 2023, 2072, 2091, 2109, 2158, 2174, 2196, 2293, 2374, 2402, 2438, 2465, 2482, 2490, 2503, 2543, 2552, 2607, 2709, 3061, 3248, 3305, 3309, 3412, 3536, 3885, 4083, 4141, 4378, 4438, 4578, 4825, 4845, 5130, 5566, 5652], 'purpose': [35, 311], 'delineating': [37, 313], 'signaling': [39, 127, 234, 259, 315, 403, 510, 535, 1545, 3029, 3665, 4426, 4582, 4614, 4626, 5431], 'pathway': [40, 316, 1708, 4615, 4627, 5218, 5409], 'leading': [41, 317, 4778, 4856, 5368], 'to': [42, 50, 120, 158, 176, 194, 199, 209, 263, 272, 318, 326, 396, 434, 452, 470, 475, 485, 539, 548, 772, 779, 784, 807, 944, 1253, 1543, 1845, 2045, 2225, 2238, 2510, 2743, 3075, 3121, 3339, 3480, 3486, 3510, 3524, 3590, 3620, 3636, 3639, 3650, 3661, 3773, 3783, 3799, 3802, 3872, 3878, 3893, 3916, 3950, 3976, 4045, 4137, 4203, 4213, 4227, 4241, 4287, 4306, 4319, 4424, 4456, 4483, 4509, 4539, 4566, 4599, 4603, 4704, 4779, 4842, 4857, 4961, 5001, 5013, 5028, 5177, 5226, 5240, 5248, 5369, 5421, 5452, 5492, 5587], 'acquisition': [44, 320], 'angiogenic': [47, 256, 323, 532, 1004, 1300, 1353, 1854, 3033, 3253, 5382, 5408], 'phenotype': [48, 324], 'and': [49, 166, 221, 325, 442, 497, 608, 628, 650, 818, 1001, 1030, 1306, 1373, 1455, 1540, 1598, 1662, 1718, 1735, 1749, 1809, 1843, 1848, 1861, 1870, 1879, 1907, 1917, 1946, 2037, 2082, 2120, 2195, 2294, 2327, 2371, 2397, 2404, 2463, 2531, 2545, 2626, 2634, 2760, 2771, 2783, 2796, 2818, 2858, 3114, 3169, 3261, 3307, 3312, 3316, 3370, 3434, 3579, 3656, 3669, 3724, 3839, 3864, 3965, 4146, 4217, 4220, 4303, 4338, 4462, 4499, 4505, 4541, 4570, 4650, 4667, 4672, 4744, 4775, 4872, 4938, 4946, 5232, 5245, 5270, 5365, 5372, 5425, 5600], 'new': [51, 327, 2885], 'vessel': [52, 328, 2655], 'formation.': [53, 329], '(100': [55, 331, 2053, 2160, 2207, 2242, 2508], 'nm)': [56, 332, 2054, 2161], 'produced': [57, 333, 3226, 3452, 4149], 'activation': [58, 132, 135, 334, 408, 411, 1452, 1531, 1604, 1858, 3297, 3357, 3369, 3490, 3582, 3675, 3727, 3757, 3807, 3851, 4044, 4316, 4522, 4649, 4669, 4791, 4801, 4970, 5011, 5043, 5064, 5469], 'fibroblast': [61, 149, 337, 425, 748, 1013, 4659], 'growth': [62, 77, 150, 338, 353, 426, 572, 582, 585, 607, 730, 744, 749, 815, 821, 1010, 1014, 1740, 1864, 1925, 3342, 3672, 3804, 4429, 4660, 4847, 4965, 5107, 5165], 'factor': [63, 78, 339, 354, 731, 745, 750, 816, 1865, 3254, 3673, 3805, 4848, 4966, 5166], 'receptor': [64, 79, 189, 238, 340, 355, 465, 514, 733, 747, 752, 789, 846, 1588, 1655, 2205, 2613, 3406, 3489, 3533, 3622, 3674, 3806, 4120, 4254, 4269, 4346, 4393, 4553, 4656, 4790, 4858, 4969, 5022, 5360, 5644], '1': [65, 341, 2477, 2519], '(FGFR-1),': [66, 342], 'measured': [68, 344, 3155, 3865], 'by': [69, 89, 185, 231, 237, 345, 365, 461, 507, 513, 617, 770, 998, 1201, 1603, 1937, 2127, 2325, 2550, 2559, 2714, 2719, 2841, 3036, 3051, 3147, 3174, 3251, 3298, 3332, 3401, 3408, 3466, 3599, 3623, 3758, 3833, 3854, 3912, 3955, 3999, 4015, 4404, 4428, 4548, 4773, 4822, 4829, 4971, 5005, 5033, 5065, 5118, 5210, 5256, 5260, 5540, 5595, 5610], 'its': [70, 121, 205, 346, 397, 481, 780, 936, 2876, 3115, 3122, 3368, 3394, 3726, 3760, 3891, 3909, 3914, 3977, 4454, 4542, 4549, 4780, 4793, 5010, 5017, 5157, 5222, 5373, 5468, 5493, 5607], 'phosphorylation,': [71, 347, 2087, 4244], 'but': [72, 348, 3629, 4277, 4340], 'not': [73, 115, 169, 349, 391, 445, 1817, 3118, 3192, 3337, 3348, 3970, 4279, 4342, 4383], 'vascular': [75, 351, 742, 1008, 1025, 1460, 3210, 3365, 4640, 4697, 5250, 5454, 5494, 5628], '2.': [80, 356], 'stimulated': [82, 218, 358, 494, 2071, 2157, 2373, 3308, 5004], 'EP3': [84, 92, 111, 167, 360, 368, 387, 443, 1654, 4111, 4174, 4253, 4313, 4345, 4392, 5269, 5356], 'subtype': [85, 361, 1657, 2619, 4121, 4134, 4194, 4258, 5361], 'receptor,': [86, 112, 122, 362, 388, 398, 782, 1866, 4849], 'deduced': [88, 364], 'abrogation': [90, 366], 'Gαi': [93, 369, 4205], 'subunit': [94, 370], 'activity': [95, 371, 1347, 3048, 3136, 3201, 4006, 4755], 'through': [96, 251, 372, 527, 796, 1206, 1284, 1744, 2862, 3436, 3793, 3813, 3827, 4059, 4646, 4792, 4879, 5068, 5193, 5439, 5623], 'pertussis': [97, 373, 2197, 2757, 4199, 4245], 'toxin.': [98, 374], 'Consistent': [99, 375, 4082], 'this': [101, 242, 377, 518, 1821, 3090, 3344, 3464, 3546, 3961, 4084, 4102, 4296, 4329, 4727, 5146, 5418, 5555], 'result,': [102, 378, 4085], 'human': [104, 380, 738, 1459, 1902, 1908, 4321, 4373, 4463, 4572, 5265], 'umbilical': [105, 381, 1909, 4322, 4374], 'missing': [109, 385], 'did': [114, 168, 390, 444, 3191, 4278, 4382], 'phosphorylate': [116, 392, 3894, 4138], 'FGFR-1.': [117, 393, 1867, 3732, 4139, 4264], 'Upon': [118, 394], 'binding': [119, 395, 778, 3915, 3949, 3975], 'initiated': [124, 400], 'an': [125, 401, 849, 1533, 2720, 2729, 3214, 3814, 4060, 4836, 4853, 5403, 5440, 5449, 5528], 'autocrine/paracrine': [126, 402, 4061, 5450], 'cascade': [128, 404, 794, 852, 4583, 5196, 5377], 'involving': [129, 405, 853], 'intracellular': [131, 407, 850, 1536, 5189], 'c-Src,': [134, 410, 856, 5066], 'matrix': [137, 413, 1022, 3840], 'metalloproteinase': [138, 414, 753, 4103], '(predominantly': [139, 415], 'MMP2),': [140, 416], 'which': [141, 227, 267, 417, 503, 543, 620, 857, 985, 1276, 3329, 4189, 4759, 4818, 4830, 4875, 5135, 5412, 5446, 5487, 5626], 'turn': [143, 419], 'caused': [144, 420, 5539], 'mobilization': [146, 422, 3998, 4048], 'membrane-anchored': [148, 424], 'factor-2': [151, 427, 1015], '(FGF-2).': [152, 428], 'In': [153, 240, 429, 516, 840, 1441, 1820, 2691, 3127, 5170, 5433, 5554, 5603], 'fact,': [154, 430], 'unable': [157, 433, 4240], 'release': [159, 435, 810, 5474], 'FGF-2': [160, 436, 1734, 2163, 2375, 2528, 2547, 2567, 2686, 2777, 3149, 3255, 3443, 3540, 3565, 3815, 3832, 3863, 3907, 3948, 3974, 3989, 3997, 4050, 4070, 4109, 4293, 4339, 5133, 5155, 5179], 'transfection': [162, 438], 'both': [164, 440, 1835, 3667, 3778, 4503, 5479], 'FGFR-1': [165, 172, 214, 250, 441, 448, 490, 526, 1933, 2863, 3172, 3268, 3296, 3333, 3356, 3375, 3382, 3398, 3422, 3457, 3477, 3520, 3570, 3581, 3598, 3610, 3628, 3641, 3756, 3781, 3792, 3812, 3853, 3869, 3895, 4011, 4034, 4057, 4096, 4115, 4125, 4153, 4283, 4315, 4385, 4397, 4506, 4560, 4734, 4764, 4769, 4800, 4823, 4833, 5014, 5024, 5046, 5168, 5370, 5622], 'result': [170, 446], 'phosphorylation': [173, 206, 449, 482, 851, 3423, 3458, 3593, 3642, 3743, 3761, 3782, 3867, 4012, 4035, 4058, 4097, 4151, 4166, 4262, 4386, 4398, 4447, 4478, 4532, 4551, 4651, 4834, 5015, 5025, 5071, 5139, 5223, 5371], 'response': [175, 451, 3074, 3245, 3479, 3871, 4286, 4318, 4538, 4602, 5027], 'PGE2.': [177, 453, 2075, 2690, 2710, 3873, 5211], 'Relevance': [178, 454], 'for': [179, 246, 455, 522, 950, 1813, 1840, 2020, 2166, 2192, 2201, 2228, 2299, 2329, 2368, 2382, 2394, 2416, 2431, 2453, 2476, 2518, 2533, 2566, 2631, 2640, 2750, 2808, 2837, 3069, 3217, 3862, 4131, 4171, 4192, 4289, 4396, 4616, 4657, 4692, 4799, 4805, 4866, 4964, 5413, 5488, 5531, 5640], 'FGF2-FGFR-1': [181, 457], 'system': [182, 458, 3216, 5461], 'was': [183, 459, 1309, 2055, 2132, 2247, 2322, 2529, 2548, 2557, 2657, 2706, 2717, 2778, 2803, 2831, 2848, 3077, 3202, 3246, 3284, 3336, 3399, 3583, 4013, 4159, 4167, 4239, 4481, 4703, 4760, 4811, 4819, 5030, 5207, 5224], 'highlighted': [184, 460], 'confocal': [186, 462, 3550, 4776], 'analysis,': [187, 463, 4777], 'showing': [188, 464], 'internalization': [190, 466, 3534, 3568], 'after': [191, 467, 1451, 2121, 3055, 4453, 4472, 4552], 'exposure': [193, 469], 'prostanoid.': [196, 472], 'ERK1/2': [197, 473, 1606, 1860, 2086, 4403, 4413, 4446, 4480, 4510, 4521, 4531, 4668], 'appeared': [198, 474], 'be': [200, 476, 3119, 3800, 4962, 5002, 5527], 'distal': [202, 478], 'signal': [203, 479, 793, 5201, 5213, 5442], 'involved,': [204, 480], 'being': [207, 483, 3081, 4435, 4950], 'sensitive': [208, 484, 4482, 5225], 'either': [210, 486, 1265, 2878, 5541], 'cSrc': [211, 487], 'inhibitor': [212, 488, 2189, 2702, 4020], 'or': [213, 236, 489, 512, 1269, 1529, 2033, 2095, 2162, 2187, 2219, 2232, 2378, 2617, 2622, 2687, 2794, 2812, 2840, 2887, 3150, 3564, 4236, 4493, 4592, 4719, 5109, 5543, 5574], 'blocker.': [215, 491], 'Finally,': [216, 492, 1664], 'migration': [220, 496, 1597, 3054, 3158, 4666], 'capillary': [222, 498, 734, 3274], 'formation': [223, 499, 1375, 1724, 2883, 3228, 3325], 'aortic': [225, 501, 1729, 3301, 4676], 'rings,': [226, 502], 'were': [228, 504, 1303, 1877, 1913, 1935, 1989, 2018, 2043, 2064, 2070, 2089, 2115, 2125, 2156, 2172, 2223, 2236, 2275, 2291, 2305, 2356, 2366, 2390, 2407, 2436, 2460, 2487, 2501, 2540, 2568, 2596, 2681, 2762, 2774, 2786, 2799, 2820, 3303, 3330, 4135, 4326], 'severely': [229, 505, 4595], 'reduced': [230, 506, 4095, 4550, 4596], 'inhibitors': [232, 508, 2084, 4484, 4579, 5229], 'molecules': [235, 511], 'antagonist.': [239, 515], 'conclusion,': [241, 517, 5604], 'study': [243, 519, 4623, 4728, 5419], 'provides': [244, 520], 'evidence': [245, 521, 978, 4798, 5353], 'involvement': [248, 524, 3380, 5391], 'FGF2': [252, 528], 'eliciting': [254, 530], 'responses.': [257, 533], 'This': [258, 534, 612, 3025, 4622, 5212, 5376], 'pattern': [260, 536, 4954], 'is': [261, 537, 554, 599, 996, 1251, 1257, 1343, 1601, 1731, 2734, 3108, 3953, 4104, 4255, 4394, 5053, 5357, 5470, 5490], 'similar': [262, 538, 3785, 4953], 'autocrine-paracrine': [265, 541], 'mechanism': [266, 542, 3484, 3608, 3796, 4561, 4828, 5190, 5614], 'operates': [268, 544, 5192, 5447, 5462], 'support': [273, 549], 'neovascular': [274, 550], 'growth.': [275, 551, 1361], 'Chronic': [552], 'inflammation': [553, 5542, 5599], 'critical': [556, 1591], 'component': [557], 'progression.': [560, 5602], '(PGE2),': [563], '2The': [564], 'abbreviations': [565], 'used': [566, 2056, 3088, 3549, 3857, 4198, 5416], 'are:': [567], 'PGE2prostaglandin': [568], 'E2ERKextracellular': [569], 'signal-regulated': [570, 727], 'kinaseEGFepidermal': [571], 'factorEGFREGF': [573], 'receptorCVECcapillary': [574], 'cellsHMVEC-Chuman': [577], 'cellsVEGFvascular': [580], 'factorVEGFRVEGF': [583], 'receptorFGFfibroblast': [584], 'factorFGFRFGF': [586], 'receptorMMPmetalloproteinaseCHOChinese': [587], 'hamster': [588, 755, 1928], 'ovaryPBSphosphate-buffered': [589], 'saline.': [590, 758], 'once': [591], 'viewed': [592], 'prototypical': [595], 'mediator': [596, 3666, 4736], 'inflammation,': [598], 'now': [600, 1258], 'regarded': [601], 'promoter': [604, 4747], 'neoplastic': [606], 'angiogenesis.': [611, 1663, 3219], 'notion': [613], 'has': [614, 764, 941, 1444, 3647, 3658, 4332, 4684, 4958, 5568], 'been': [615, 942, 1445, 2870, 3648, 3659, 4685, 4863, 4959, 5274], 'established': [616, 1290], 'experimental': [618, 762, 1197, 3345], 'studies': [619, 763, 1268], 'show': [621], 'increased': [622], 'expression': [623, 1000, 1208, 1746, 2102, 4294, 4618, 4808], 'cyclooxygenase': [625], 'isoforms': [626], '(COX-1': [627], 'COX-2)': [629], 'enhanced': [633, 999, 4815], 'levels': [634, 1537], 'PGE2,': [636, 2753, 3299, 3481, 3855, 4320, 4645, 4877, 5411], 'major': [638, 4106], 'product': [639], 'their': [641, 993, 1836, 3165, 4597, 5112, 5125], 'enzyme': [642], 'activity,': [643, 939, 4414], 'several': [645, 2873, 5552], 'tissues': [647], '(i.e.': [648, 1028], 'colon': [649], 'breast': [651, 1198], 'tumors)': [652], '(1Wang': [653, 958, 1311], 'D.': [654, 872, 888, 959, 1312, 1962, 3679, 4984, 5085, 5510], 'DuBois': [655, 891, 960, 1313, 3682], 'R.N.': [656, 714, 892, 961, 1314, 3683], 'Proc.': [657, 962, 1231, 1315], 'Natl.': [658, 963, 1232, 1316, 2996], 'Acad.': [659, 964, 1233, 1317], 'Sci.': [660, 965, 1116, 1165, 1234, 1318, 2146, 2261, 2342, 2671], 'U.': [661, 966, 1235, 1319], 'S.': [662, 673, 681, 910, 967, 1089, 1126, 1155, 1179, 1236, 1320, 1377, 1464, 1627, 1629, 1631, 1669, 1761, 1968, 2002, 2138, 2253, 2334, 2573, 2575, 2663, 2898, 2971, 3926, 4901, 4909, 5327, 5329, 5331], 'A.': [663, 675, 823, 831, 918, 968, 1237, 1321, 1424, 1511, 1568, 1621, 1956, 2006, 2579, 2945, 3007, 3496, 4352, 4890, 5295, 5321], '2004;': [664, 969, 1073, 1238, 1322, 2147, 2262, 2343, 2672, 3707], '101:': [665, 970, 1239, 1323], '415-416Crossref': [666, 971, 1324], 'PubMed': [667, 687, 704, 719, 880, 904, 930, 972, 1081, 1095, 1120, 1135, 1169, 1187, 1241, 1325, 1402, 1436, 1489, 1523, 1580, 1647, 1694, 1774, 1801, 1981, 2150, 2265, 2346, 2588, 2675, 2923, 2957, 2984, 3020, 3501, 3695, 3710, 3940, 4366, 4895, 4927, 4992, 5099, 5307, 5347, 5519], 'Scopus': [668, 688, 705, 720, 836, 881, 905, 931, 973, 1082, 1096, 1121, 1136, 1170, 1188, 1242, 1326, 1403, 1437, 1490, 1524, 1581, 1648, 1695, 1775, 1802, 1982, 2151, 2266, 2347, 2589, 2676, 2924, 2958, 2985, 3021, 3502, 3696, 3711, 3941, 4367, 4896, 4928, 4993, 5100, 5308, 5348, 5520], '(83)': [669, 974, 1327], 'Google': [670, 690, 707, 722, 838, 883, 907, 933, 975, 1062, 1084, 1098, 1123, 1138, 1172, 1190, 1244, 1328, 1405, 1439, 1492, 1526, 1583, 1650, 1697, 1777, 1804, 1899, 1984, 2153, 2268, 2349, 2591, 2678, 2926, 2960, 2987, 3002, 3023, 3504, 3698, 3713, 3943, 4369, 4898, 4930, 4995, 5102, 5310, 5350, 5522], 'Scholar,': [671, 691, 708, 884, 908, 1063, 1085, 1099, 1124, 1139, 1173, 1406, 1493, 1778, 2927, 2961, 2988, 3003, 3699, 4899, 5311], '2Mehrotra': [672], 'Morimiya': [674], 'Agarwal': [676], 'B.': [677, 866, 1952, 4978], 'Konger': [678], 'R.': [679, 864, 914, 1220, 1408, 1410, 1420, 1495, 1497, 1507, 1552, 1554, 1564, 1763, 1780, 2929, 2931, 2941, 2973, 3930, 4976, 5087, 5279, 5281, 5291], 'Badve': [680], 'J.': [682, 893, 926, 1070, 1114, 1128, 1130, 1145, 1425, 1512, 1569, 1637, 1768, 1894, 2946, 2978, 2992, 2995, 3684, 4355, 4916, 5088, 5296, 5337, 5513], 'Pathol.': [683, 1638, 5338], '2006;': [684, 701, 1184, 1639, 2585, 3017, 3498, 5339], '208:': [685], '356-363Crossref': [686], '(77)': [689], '3Mutoh': [692], 'M.': [693, 695, 829, 870, 924, 1087, 1151, 1177, 1617, 1635, 1765, 1792, 1939, 1954, 1958, 1972, 1974, 1976, 2008, 2144, 2259, 2340, 2581, 2669, 2975, 2990, 3005, 3922, 3932, 4350, 4982, 5077, 5317, 5335], 'Takahashi': [694, 1160], 'Wakabayashi': [696], 'K.': [697, 1141, 1147, 1161, 1224, 1788], 'Curr.': [698], 'Pharm.': [699], 'Des.': [700], '12:': [702, 1118], '2375-2382Crossref': [703], '(56)': [706], '4Backlund': [709], 'M.G.': [710], 'Mann': [711], 'J.R.': [712, 1890], 'Dubois': [713], 'Oncology.': [715], '2005;': [716, 1092, 1117, 1132, 1166, 1399, 1486, 1691, 2920, 3937], '69:': [717, 3000], '28-32Crossref': [718], '(87)': [721], 'Scholar).': [723, 839, 934, 976, 1191, 1245, 1329, 1440, 1527, 1805, 1900, 1985, 2015, 2154, 2269, 2350, 2592, 2679, 3024, 3505, 3944, 4370, 4931, 4996, 5351, 5523], 'prostaglandin': [724, 2611, 3995, 5642], 'extracellular': [726, 809, 3829, 5147], 'kinase': [728, 3270, 3488, 4416, 4655, 4968], 'epidermal': [729], 'EGF': [732, 845, 860], 'VEGF': [746, 5390, 5428, 5473, 5489, 5547, 5565], 'FGF': [751], 'Chinese': [754, 1927], 'ovary': [756, 1929], 'phosphate-buffered': [757], 'A': [759, 4498], 'wealth': [760], 'delineated': [765, 4584], 'molecular': [767, 1810], 'mechanisms': [768, 1811, 3030, 4861], 'utilized': [769], 'induce': [773, 1742, 3640, 5104], 'proliferation.': [775, 5455], 'upon': [777, 5063], 'membrane': [781, 4052, 4423, 5158], 'belonging': [783, 4565], 'classical': [786], 'G': [787, 2472, 4880, 4972], 'protein-coupled': [788, 4881, 4973], 'family,': [790], 'activates': [791, 3719, 3791], 'that': [795, 980, 1195, 1249, 1365, 1447, 1586, 1600, 1700, 1719, 3106, 3249, 3355, 3774, 3789, 3797, 3822, 3903, 3947, 3967, 4040, 4075, 4101, 4252, 4390, 4502, 4644, 4951, 5040, 5051, 5121, 5151, 5191, 5355, 5362, 5426, 5582], 'complex': [798], 'array': [799], 'intermediate': [801, 3978, 4942, 5070], 'steps': [802], '(c-Src,': [803], 'PKC,': [804], 'Pyk2),': [805], 'leads': [806], 'peptide': [812], 'ligands': [813, 1027, 5120], 'stimulating': [814], 'receptors': [817, 1032, 1457, 2105, 2814, 3167, 4882, 4974, 5272], 'producing': [819, 1852], '(5Gschwind': [822], 'Zwick': [824], 'E.': [825, 916, 1153, 1613, 1759, 2969, 3928, 5079, 5313], 'Prenzel': [826], 'N.': [827, 1157, 1633, 1786, 5333], 'Leserer': [828], 'Ullrich': [830, 4889], 'Oncogene.': [832, 3016, 3706], '2001;': [833, 1771, 2981], '20:': [834], '1595-1600Crossref': [835], '(414)': [837], 'parallel,': [841], 'transactivates': [843], '(EGFR)': [847], 'via': [848], 'protooncogene': [855], 'magnifies': [858], 'tumorigenic': [861], 'drive': [862, 1254, 5383], '(6Pai': [863, 4975], 'Soreghan': [865, 4977], 'Szabo': [867, 4979], 'I.L.': [868, 4980], 'Pavelka': [869, 4981], 'Baatar': [871, 4983], 'Tarnawski': [873, 4985], 'A.S.': [874, 4986], 'Nat.': [875, 4987], 'Med.': [876, 1398, 1485, 1690, 1770, 2919, 2980, 4988], '2002;': [877, 1059, 1978, 4358, 4989, 5516], '8:': [878, 4990], '289-293Crossref': [879, 4991], '(776)': [882, 4994], '7Buchanan': [885], 'F.G.': [886, 3677], 'Wang': [887, 1106, 3678], 'Bargiacchi': [889, 3680], 'F.': [890, 912, 2004, 3681], 'Biol.': [894, 1071, 1426, 1513, 1570, 2947, 3685, 4356, 4917, 5089, 5297, 5515], 'Chem.': [895, 1072, 1427, 1514, 1571, 2948, 3686, 4357, 4918, 5090, 5298], '2003;': [896, 1798, 2012, 3687], '278:': [897, 3688], '35451-35457Abstract': [898, 3689], 'Full': [899, 901, 1076, 1078, 1431, 1433, 1518, 1520, 1575, 1577, 1642, 1644, 2952, 2954, 3690, 3692, 4361, 4363, 4922, 4924, 5094, 5096, 5302, 5304, 5342, 5344], 'Text': [900, 902, 1077, 1079, 1432, 1434, 1519, 1521, 1576, 1578, 1643, 1645, 2953, 2955, 3691, 3693, 4362, 4364, 4923, 4925, 5095, 5097, 5303, 5305, 5343, 5345], 'PDF': [903, 1080, 1435, 1522, 1579, 1646, 2956, 3694, 4365, 4926, 5098, 5306, 5346], '(425)': [906, 3697], '8Donnini': [909], 'Finetti': [911], 'Solito': [913], 'Terzuoli': [915], 'Sacchetti': [917], 'Morbidelli': [919, 2139, 2254, 2335, 2576, 2664], 'L.': [920, 2000, 2140, 2255, 2336, 2577, 2665, 3009], 'Patrignani': [921], 'P.': [922, 1065, 1964, 3924], 'Ziche': [923, 2007, 2143, 2258, 2339, 2580, 2668], 'FASEB': [925], '2007;': [927, 1428, 1515, 1572, 2949, 5091, 5299], '21:': [928], '2418-2430Crossref': [929], '(85)': [932], 'Complementing': [935], 'promoting': [938, 3367], 'found': [943, 4812, 4999], 'activate': [945, 3651], 'angiogenesis,': [947, 1297, 5589], 'thus': [948, 3530], 'providing': [949], 'blood': [952], 'supply': [953], 'needs': [954], 'proliferating': [956], 'tumors': [957, 989], 'Experimental': [977], 'shows': [979], 'overexpression': [982, 4276], 'cyclooxygenase-2,': [984, 1210, 1287], 'characterizes': [986], 'population,': [995], 'accompanied': [997], 'production': [1002, 1751], 'factors': [1005, 1011, 4430, 5108, 5205], 'such': [1006, 1856, 3143, 4431, 4489, 4586, 4715], '(VEGF),': [1012], '(FGF-2),': [1016], 'hypoxia-inducible': [1017], 'factor-1,': [1018], 'matrix-degrading': [1019], 'enzymes': [1020], '(e.g.': [1021, 4869, 5564], 'metalloproteinases': [1023], '(MMPs)),': [1024], 'remodeling': [1026], 'angiopoietins),': [1029], 'adhesion': [1031], 'integrin': [1035], 'families': [1036], '(9Mohammed': [1037], 'S.I.': [1038], 'Bennett': [1039], 'P.F.': [1040], 'Craig': [1041], 'B.A.': [1042], 'Glickman': [1043], 'N.W.': [1044], 'Mutsaers': [1045], 'A.J.': [1046], 'Snyder': [1047], 'P.W.': [1048], 'Widmer': [1049], 'W.R.': [1050], 'DeGortari': [1051], 'A.E.': [1052], 'Bonney': [1053], 'P.L.': [1054], 'Knapp': [1055], 'D.W.': [1056], 'Cancer': [1057, 1164, 2010, 2997], 'Res.': [1058, 2011], '62:': [1060], '356-358PubMed': [1061], '10Pichiule': [1064], 'Chavez': [1066], 'J.C.': [1067, 1069], 'LaManna': [1068], '279:': [1074], '12171-12180Abstract': [1075], '(160)': [1083], '11Abdelrahim': [1086], 'Safe': [1088], 'Mol.': [1090, 1397, 1484, 1689, 2918], 'Pharmacol.': [1091], '68:': [1093], '317-329Crossref': [1094], '(111)': [1097], '12Huang': [1100], 'S.P.': [1101], 'Wu': [1102], 'M.S.': [1103], 'Shun': [1104], 'C.T.': [1105], 'H.P.': [1107], 'Hsieh': [1108], 'C.Y.': [1109], 'Kuo': [1110], 'M.L.': [1111], 'Lin': [1112, 3014], 'J.T.': [1113], 'Biomed.': [1115], '229-241Crossref': [1119], '(100)': [1122], '13Han': [1125], 'Roman': [1127], 'Int.': [1129], 'Cancer.': [1131, 1183], '116:': [1133], '536-546Crossref': [1134], '(26)': [1137, 1171], '14Yazawa': [1140], 'Tsuno': [1142], 'N.H.': [1143], 'Kitayama': [1144], 'Kawai': [1146], 'Okaji': [1148], 'Y.': [1149, 1414, 1501, 1558, 1615, 1625, 2935, 4911, 5285, 5315, 5325], 'Asakage': [1150], 'Sunami': [1152], 'Kaisaki': [1154], 'Hori': [1156], 'Watanabe': [1158], 'T.': [1159, 1230, 1623, 3494, 5323], 'Nagawa': [1162], 'H.': [1163, 1387, 1474, 1619, 1679, 2908, 3703, 4884, 5319], '96:': [1167], '93-99Crossref': [1168], '15Larkins': [1174], 'T.L.': [1175], 'Nowell': [1176], 'Singh': [1178], 'Sanford': [1180], 'G.L.': [1181, 1753, 2963], 'BMC': [1182], '6:': [1185], '181Crossref': [1186], '(142)': [1189], 'Indeed,': [1192, 3171, 4997], 'it': [1193, 1443, 5549], 'appears': [1194, 1338, 3798], 'tumors,': [1199], 'characterized': [1200, 5594], 'high': [1202], 'output': [1203, 5545], 'forced': [1207], 'angiogenesis': [1211, 1256, 1337, 1450, 1743, 1815, 1841, 3142, 5277, 5438, 5538], 'proceeds': [1212], 'development': [1214], '(16Chang': [1215], 'S.H.': [1216], 'Liu': [1217], 'C.H.': [1218], 'Conway': [1219], 'Han': [1221, 1388, 1475, 1680, 2909], 'D.K.': [1222], 'Nithipatikom': [1223], 'Trifan': [1225], 'O.C.': [1226], 'Lane': [1227], 'T.F.': [1228], 'Hla': [1229], '591-596Crossref': [1240], '(346)': [1243], 'Thus,': [1246, 4054, 4305], 'concept': [1248, 5581], 'capable': [1252], 'firmly': [1259], 'grounded.': [1260], 'Numerous': [1261], 'clinical': [1262], 'investigations': [1263, 1271], 'conducted': [1264, 4695], 'population': [1267], 'specific': [1270, 4191, 5018, 5185], 'nonsteroidal': [1273], 'anti-inflammatory': [1274], 'drugs,': [1275], 'produce': [1277, 4242], 'decrease': [1279], 'tissue': [1282], 'level': [1283], 'blockade': [1285, 3173, 4824, 5019], 'have': [1288, 1824, 2869, 3846, 4862, 5273, 5429], 'further': [1289, 3899], 'crucial': [1292], 'role': [1293, 1592, 2697, 3848, 4311, 4732], 'prostanoid': [1295, 1350, 3066, 3588, 3824, 4620], 'since': [1298, 4328], 'most': [1299, 4723], 'markers': [1301], 'examined': [1302, 3389, 3819, 3992, 4128, 4407], 'definitely': [1304], 'down-regulated,': [1305], 'progression': [1308], 'halted': [1310], 'Although': [1330, 4232], 'action': [1332, 1827, 3195, 4631, 4707, 5395, 5609], 'tumor-associated': [1336], 'documented,': [1340], 'much': [1341], 'less': [1342], 'known': [1344, 3483, 3768], 'about': [1345], 'process': [1354, 4009], 'outside': [1355], 'context': [1358, 5556], 'Previous': [1362], 'reports': [1363, 2874], 'indicated': [1364, 1652, 4074, 5050, 5255], 'induces': [1367, 1449, 1532, 4042, 4663], 'directly': [1368, 3618, 3971, 4844], 'proliferation,': [1371], 'migration,': [1372, 3180], 'tube': [1374], '(17Namkoong': [1376, 1463, 1668, 2897], 'Lee': [1378, 1386, 1465, 1473, 1670, 1678, 2899, 2907], 'S.J.': [1379, 1466, 1671, 2900], 'Kim': [1380, 1382, 1394, 1467, 1469, 1481, 1672, 1674, 1686, 2901, 2903, 2915], 'C.K.': [1381, 1468, 1673, 2902], 'Y.M.': [1383, 1395, 1470, 1482, 1675, 1687, 2904, 2916], 'Chung': [1384, 1471, 1676, 2905], 'H.T.': [1385, 1472, 1677, 2906], 'J.A.': [1389, 1476, 1681, 2910], 'Ha': [1390, 1477, 1682, 2911], 'K.S.': [1391, 1478, 1683, 2912], 'Kwon': [1392, 1479, 1684, 2913], 'Y.G.': [1393, 1480, 1685, 2914], 'Exp.': [1396, 1483, 1688, 1769, 2917, 2979], '37:': [1400, 1487, 1692, 2921], '588-600Crossref': [1401, 1488, 1693, 2922], '(105)': [1404, 1491, 1696, 2925], '18Rao': [1407, 1494, 2928], 'Redha': [1409, 1496, 1553, 2930, 5280], 'Macias-Perez': [1411, 1498, 1555, 2932, 5282], 'I.': [1412, 1499, 1556, 2933, 5283], 'Su': [1413, 1500, 1557, 2934, 5284], 'Hwang': [1415, 1502, 1559, 2936, 5286], 'M.T.': [1416, 1503, 1560, 2937, 5287], 'Hao': [1417, 1504, 1561, 2938, 5288], 'C.': [1418, 1505, 1562, 1970, 2939, 4354, 4888, 5075, 5081, 5289], 'Zent': [1419, 1506, 1563, 2940, 5290], 'Breyer': [1421, 1508, 1565, 2942, 3012, 5292], 'M.D.': [1422, 1509, 1566, 2943, 5293], 'Pozzi': [1423, 1510, 1567, 2944, 3006, 5294], '282:': [1429, 1516, 1573, 2950, 5092, 5300], '16959-16968Abstract': [1430, 1517, 1574, 2951, 5301], '(116)': [1438, 1525, 1582, 2959, 5309], 'particular': [1442], 'demonstrated': [1446, 1585, 1699, 4643, 4960], 'EP2': [1454, 1528, 4157, 4216], 'EP4': [1456, 1530, 1587, 2813, 4218, 5271], 'increase': [1534, 3425, 3739, 4469], 'cAMP': [1539, 4209, 4234], 'ERK1/2,': [1541, 5199], 'linked': [1542, 3485, 5012], 'different': [1544, 3469, 5243], 'pathways.': [1546], 'Recently,': [1547], 'Rao': [1548], 'et': [1549, 1610, 1666], 'al.': [1550, 1611, 1667], '(18Rao': [1551, 5278], 'Scholar)': [1584, 1651, 1698], 'plays': [1589], 'PGE2-dependent': [1594], 'vitro': [1596, 1714, 4671], 'tubulogenesis': [1599], 'mediated': [1602], 'pathway.': [1607], 'Moreover,': [1608, 1733], 'Kamoshita': [1609], '(19Kamoshita': [1612], 'Ikeda': [1614, 5314], 'Fujita': [1616, 5316], 'Amano': [1618, 5318], 'Oikawa': [1620, 5320], 'Suzuki': [1622, 5322], 'Ogawa': [1624, 5324], 'Yamashina': [1626, 5326], 'Azuma': [1628, 5328], 'Narumiya': [1630, 5330], 'Unno': [1632, 5332], 'Majima': [1634, 5334], 'Am.': [1636, 1893, 5336], '169:': [1640, 5340], '1458-1472Abstract': [1641, 5341], '(48)': [1649, 2152, 2267, 2348, 2677, 5349], 'involved': [1658, 1850, 4068, 4122, 4259, 4628, 5056], 'wound': [1660], 'healing': [1661], 'Namkoong': [1665], 'pharmacological': [1701, 5532], 'inhibition': [1702, 4087], 'nitric-oxide': [1705], 'synthase': [1706], '(eNOS)': [1707], 'inhibits': [1709], 'PGE2-induced': [1710, 1814, 3156, 3273, 3755, 4124, 4261, 4477, 5138], 'proliferation': [1711], 'cultured': [1715, 1880, 1947, 2276, 2636, 2889, 3039, 4688, 5399], 'eNOS-deficient': [1721], 'mice': [1722], 'capillary-like': [1726, 3234, 3327], 'structure': [1727], 'rings': [1730, 2656, 4677], 'abolished.': [1732], 'VEGF,': [1736], 'two': [1737], 'effective': [1738], 'pro-angiogenic': [1739, 3200, 4636, 5394, 5608], 'factors,': [1741], 'increasing': [1745, 2504, 3062], 'cyclooxygenases': [1748], '(20Hernandez': [1752], 'Volpert': [1754, 2964], 'O.V.': [1755, 2965], 'Iniguez': [1756, 2966], 'M.A.': [1757, 2967], 'Lorenzo': [1758, 2968], 'Martinez-Martinez': [1760, 2970], 'Grau': [1762, 2972], 'Fresno': [1764, 2974], 'Redondo': [1766, 2976], 'J.M.': [1767, 2977], '193:': [1772, 2982], '607-620Crossref': [1773, 2983], '(387)': [1776, 2986], '21Salcedo': [1779], 'Zhang': [1781], 'X.': [1782], 'Young': [1783], 'H.A.': [1784], 'Michael': [1785], 'Wasserman': [1787], 'Ma': [1789], 'W.H.': [1790], 'Martins-Green': [1791], 'Murphy': [1793, 5082], 'W.J.': [1794], 'Oppenheim': [1795], 'J.J.': [1796], 'Blood.': [1797], '102:': [1799], '1966-1977Crossref': [1800], '(163)': [1803], 'However,': [1806, 5478], 'functional': [1808, 1837, 2893, 4439, 4609, 4807], 'necessary': [1812], 'are': [1816, 4190, 5122], 'completely': [1818], 'understood.': [1819], 'work': [1822, 3026, 4683], 'we': [1823, 3044, 3132, 3388, 3548, 3612, 3715, 3787, 3856, 3991, 4038, 4184, 4197, 4850, 4998], 'examining': [1834], 'properties': [1838, 2866], 'relevant': [1839], '(migration': [1842], 'ability': [1844, 3892, 4180, 4598], 'form': [1846], 'pseudocapillaries)': [1847], 'signals': [1849, 3362, 4486, 4943], 'phenotype,': [1855], 'Cell': [1868, 1921, 1986, 2582, 2593, 2789, 2856, 5514], 'Line': [1869], 'Culture': [1871], 'Conditions—Post-capillary': [1872], '(CVEC)': [1876], 'obtained': [1878, 2763, 5259], 'previously': [1882, 1949, 1997, 2135, 2250, 2660], 'described': [1883, 1950, 1998, 2136, 2251, 2332, 2571, 2661, 3386, 4487, 4865], '(22Schelling': [1884], 'M.E.': [1885], 'Meininger': [1886], 'C.J.': [1887], 'Hawker': [1888], 'Jr.,': [1889], 'Granger': [1891], 'H.J.': [1892], 'Physiol.': [1895], '1988;': [1896], '254:': [1897], 'H1211-H1217PubMed': [1898], 'Cardiac-derived': [1901], '(HMVEC-C)': [1906], 'purchased': [1914, 2787], 'from': [1915, 2650, 2654, 2764, 2775, 2779, 2788, 2800, 2804, 2821, 3521, 3908, 4051, 4460, 4675, 5111, 5124, 5156, 5180, 5216, 5475, 5576], 'Cambrex': [1916], 'maintained': [1918], 'Endothelial': [1920, 2016, 2647, 2855], 'Basal': [1922], 'Medium-2': [1923], 'supplements.': [1926], 'transfected': [1931, 2108], '(CHO/FGFR-1)': [1934], 'provided': [1936], 'Prof.': [1938], 'Presta': [1940, 1975], '(University': [1941], 'Brescia,': [1943, 1944], 'Italy)': [1945], '(23Casu': [1951], 'Guerrini': [1953], 'Naggi': [1955], 'Perez': [1957], 'Torri': [1959], 'G.': [1960, 1966, 2142, 2257, 2338, 2667, 5083], 'Ribatti': [1961], 'Carminati': [1963], 'Giannini': [1965], 'Penco': [1967], 'Pisano': [1969], 'Belleri': [1971], 'Rusnati': [1973, 3931], 'Biochemistry.': [1977], '41:': [1979], '10519-10528Crossref': [1980], '(80)': [1983], 'Migration—Chemotaxis': [1987], 'experiments': [1988, 2692, 4694, 5129], 'performed': [1990, 2133, 2248, 2569, 2832, 4686], 'Boyden': [1993], 'chamber': [1994], 'technique': [1995], '(24Morbidelli': [1999], 'Donnini': [2001], 'Chillemi': [2003], 'Giachetti': [2005, 2578], 'Clin.': [2009], '9:': [2013], '358-369Google': [2014], 'treated': [2019], '30': [2021, 2193, 2432, 3881, 4024, 4090], 'min': [2022, 2194, 2396, 3431, 3438, 3882, 4091, 4452, 4474], 'U0126': [2024, 4593], '(10': [2025, 2035, 2093, 2704, 3176, 3185, 3264, 4211], 'nm),': [2026, 2029, 2183, 2208], 'PP1': [2027, 2096, 2181, 2769, 4494, 4590], '(500': [2028, 2097, 2182], 'GM6001': [2030, 2184, 4032, 4588], '(25': [2031, 2185, 2190, 4088], 'μm),': [2032, 2036, 2186, 2218, 3186, 3265], 'SU5402': [2034, 2092, 2703, 3175, 3306, 4491], 'then': [2038, 2372, 2398, 2408, 2461, 2541, 2635, 3747, 3818], '1.25': [2039], '×': [2040, 2062, 2112, 2272, 2352], '104': [2041], 'added': [2044, 2224, 2237, 2306, 2530, 2707], 'upper': [2047], 'wells': [2048], 'chamber.': [2051], 'chemoattractant.': [2058], 'Western': [2059, 2128, 2130, 2245, 2564, 3409], 'Blot—Cells': [2060], '(3': [2061], '105)': [2063], 'seeded': [2065, 2116, 2357], '60-mm-diameter': [2067], 'dishes.': [2068], 'Cells': [2069, 2365, 2406, 2459], '100': [2073, 2302, 2380, 2491, 2688, 3084, 3319, 4142, 4379], 'nm': [2074, 2303, 2381, 2509, 2689, 3068, 3085, 4143, 4380], 'To': [2076, 2099, 3291, 3543, 3842, 3981], 'assess': [2077], 'effects': [2079, 2877, 3116, 4740, 5496], 'FGFR1': [2081, 2443, 4243], 'c-Src': [2083, 3652, 3657, 3720, 3742, 3752, 3769, 3838, 4337, 4504, 4937, 5000, 5364, 5482, 5525], 'pretreated': [2090, 2173, 2489, 3304], 'μm)': [2094, 2191, 2512, 2705, 3177, 4212], 'nm).': [2098], 'evaluate': [2100], 'EP': [2104, 2204, 3631, 4182, 4268], 'CHO-FGFR1': [2107], 'EPs,': [2110], '8': [2111], '105': [2113], '100-mm-diameter': [2118], 'dishes,': [2119], '24': [2122, 2369, 2641], 'h': [2123, 2316, 2370, 2455, 2520, 2535, 2633, 2642], 'analyzed': [2126, 2558, 3045, 3204], 'blotting.': [2129], 'blot': [2131, 2246], '(25Donnini': [2137, 2252, 2333, 2662], 'Taraboletti': [2141, 2256, 2337, 2666], 'Life': [2145, 2260, 2341, 2670], '74:': [2148, 2263, 2344, 2673], '2975-2985Crossref': [2149, 2264, 2345, 2674], 'Immunoprecipitation—Cells': [2155], '(20': [2164], 'ng/ml)': [2165, 2200, 2222, 4202], '15': [2167, 2229, 2383, 3437, 4473], 'min.': [2168, 2230, 2384, 2418], 'Where': [2169], 'indicated,': [2170], 'anti-FGF-2': [2176, 2791, 2797], 'neutralizing': [2177, 3860, 5132], 'antibody': [2178, 2235, 2444, 3861, 3877], '(6': [2179], 'μg/ml),': [2180], 'MMP-2': [2188, 2772, 4078, 4086, 5052, 5153], 'toxin': [2198, 4200, 4246], '(300': [2199, 4201], '18': [2202, 2300, 2315, 2454, 2632], 'h.': [2203, 2301, 2478], 'agonists': [2206, 3314, 4130, 4148, 4172], 'adenosine': [2209], '3′,5′-cyclic': [2210], 'monophosphate,': [2211], 'N6,O2': [2212], 'dibutyryl-sodium': [2213], 'salt': [2214], '(cAMP': [2215], 'analogue,': [2216, 3097], '10': [2217, 2417, 2511, 3430], 'A23187': [2220], '(50': [2221, 4225], 'Anti-FGFR-1': [2231], 'anti': [2233, 2442], 'VEGFR-2': [2234, 3282, 3592, 4514], 'precleared': [2240], 'lysates': [2241], 'μl,': [2243], 'Sigma).': [2244], 'Gelatin': [2270], 'Zymography—6': [2271], '103': [2273, 2353], 'cells/well': [2274], '96-well': [2278], 'culture': [2280, 3212], 'plates': [2281], '10%': [2283], 'fetal': [2284, 2604], 'calf': [2285, 2605], 'serum': [2286, 2428, 2606], 'medium.': [2287, 2313], 'After': [2288, 2314, 2385, 2419], 'adhesion,': [2289], 'washed': [2292, 2399, 2462, 2542], 'incubated': [2295, 2437, 2464, 2502, 2532, 2597], 'serum-free': [2297, 2312], 'medium': [2298, 2321, 2639, 3512], '50': [2308], 'μl': [2309, 2497, 2515, 2628], 'fresh': [2311, 2638], 'incubation,': [2318], 'conditioned': [2320], 'collected,': [2323], 'clarified': [2324], 'centrifugation,': [2326], 'assayed': [2328], 'zymography': [2330], 'Immunohistochemistry—25': [2351], 'CVEC': [2354], 'cover': [2359, 2744], 'slides': [2360], '24-multiwell': [2363], 'plate.': [2364], 'starved': [2367], '20': [2376, 2413, 2684, 3450], 'ng/ml': [2377, 2685, 3451], 'stimulation': [2387, 3836, 4467, 5620], 'fixed': [2391], 'paraformaldehyde': [2393], '5': [2395, 4451], 'PBS': [2401, 2415, 2452, 2517], 'Ca2+': [2403], 'Mg2+.': [2405], 'permeabilized': [2409], '0.25%': [2411], 'Tween': [2412], 'blocking': [2421], 'unspecific': [2423], 'bindings': [2424], '3%': [2426], 'bovine': [2427, 4461], 'albumin': [2429], '(BSA)': [2430], 'min,': [2433], 'monoclonal': [2440], 'mouse': [2441, 3206, 3237, 3300], '(Upstate)': [2445], 'diluted': [2446, 2474], '1:25': [2447], '0.5%': [2449], 'BSA': [2450], 'at': [2456, 2521, 2536, 2683, 2694, 2723, 3083, 3318, 3444, 5535], '4': [2457, 2618, 3070], '°C.': [2458, 2523, 2538], 'goat': [2467], 'fluorescein': [2468], 'isothiocyanate': [2469], 'anti-mouse': [2470], 'Ig': [2471], '(Sigma)': [2473], '1:100': [2475], 'The': [2479, 2555, 2711, 2732, 3072, 3198, 3240, 3506, 3945, 4002, 4163, 4682, 4722, 4827, 5128, 5234, 5387], 'counterstained': [2481], 'propidium': [2483], 'iodide': [2484], '(1.5': [2485], 'mm)': [2486], 'also': [2488, 3203, 4064, 4117, 4526, 4767, 5031], 'μg/ml': [2492], 'DNase-free': [2493], 'RNase.': [2494], 'Heparin': [2495], 'Binding—10': [2496], 'heparin-acrylic': [2499, 2755], 'beads': [2500, 3952, 5182], 'concentration': [2505, 3087, 3448], '40': [2514], '37': [2522, 2537], 'Then': [2524], '25': [2525, 4022], 'ng': [2526], '2': [2534], 'Beads': [2539], 'PBS,': [2544], 'bound': [2546], 'removed': [2549], 'boiling': [2551], 'sample': [2553], 'buffer.': [2554], 'solution': [2556], 'SDS,': [2560], '8%': [2561], 'polyacrylamide': [2562], 'gel.': [2563], 'blots': [2565], '(26Donnini': [2572], 'Cantara': [2574], 'Death': [2583], 'Differ.': [2584], '13:': [2586], '1088-1096Crossref': [2587], '(30)': [2590], 'Transfection—Subconfluent': [2594], 'CHO-FGFR-1': [2595, 4272], "Dulbecco's": [2599], 'modified': [2600], "Eagle's": [2601], 'medium,': [2602], '1%': [2603], '6': [2608, 2627, 3578], 'μg': [2609], 'E': [2612, 5643], '1,': [2614], '2,': [2615, 3224, 3257, 3277], '3,': [2616], 'encoding': [2620, 2807, 5645], 'plasmids': [2621], 'empty': [2623], 'plasmid': [2624], '(pcDNA3.1)': [2625], 'Lipofectamine': [2630], 'before': [2643, 3883, 4026], 'use': [2644], 'experiments.': [2646], 'Tube': [2648], 'Formation': [2649, 2861], 'Aortic': [2651], 'Rings—Pseudocapillary': [2652], 'sprouting': [2653, 3275, 4674, 4817], 'evaluated': [2658, 3400, 3748], 'Stimuli': [2680], 'tested': [2682], 'aimed': [2693, 5534], 'evaluating': [2695], 'FGFR-1,': [2699, 4545, 4662, 4947, 5141], 'selective': [2701, 3267, 3310, 5228], 'together': [2708], 'area': [2712, 2733, 3527, 3573], 'occupied': [2713], 'pseudocapillary': [2715, 2747, 4673, 4816], 'structures': [2716, 3235], 'quantified': [2718], 'inverted': [2721], 'microscope': [2722], 'magnification': [2725], '200×': [2727], 'using': [2728, 2833, 3467, 3552, 3624, 4016], 'ocular': [2730], 'grid.': [2731], 'expressed': [2735], 'number': [2738], 'grid': [2740], 'units': [2741], 'required': [2742], 'entire': [2746], 'surface.': [2748], 'Reagents—Reagents': [2749], 'cultures,': [2752], 'misoprostol,': [2754], 'beads,': [2756], 'toxin,': [2758], 'A23187,': [2759, 4221], 'heparinase': [2761], 'Sigma;': [2765], 'U0126,': [2766], 'SU5402,': [2767, 3263, 5230], 'SU5614,': [2768, 3280, 4516], 'GM6001,': [2770], 'inhibitor-I': [2773], 'Calbiochem-Novabiochem;': [2776], 'Peprotech.': [2780], 'Anti-phospho-ERK1/2,': [2781], 'anti-ERK1/2,': [2782], 'anti-phosphotyrosine': [2784], 'antibodies': [2785, 2798], 'Signaling;': [2790], 'neutralizing,': [2792], 'anti-FGFR-1,': [2793], 'anti-VEGFR-2,': [2795], 'Upstate;': [2801], 'anti-β-actin': [2802], 'Sigma.': [2805], 'Plasmids': [2806], 'EP1,': [2809], 'EP2,': [2810], 'EP3,': [2811, 4208], '(PTGER1,': [2815], 'PTGER2,': [2816], 'PTGEE3,': [2817], 'PTGER4)': [2819], 'UMR': [2822], 'cDNA': [2823, 5637], 'Resource': [2824, 5638], 'Center,': [2825], 'University': [2826, 5633], 'Missouri-Rolla.': [2828], 'Statistics—Statistical': [2829], 'analysis': [2830, 2842, 3411, 4073], "Student's": [2834], 't': [2835], 'test': [2836], 'unpaired': [2838], 'data': [2839], 'variance;': [2844], 'p': [2845], '<': [2846], '0.05': [2847], 'considered': [2849], 'statistically': [2850], 'significant.': [2851], 'Induces': [2854], 'Migration': [2857], 'New': [2859], 'Vessel': [2860], 'Activation—The': [2864], 'proangiogenic': [2865], 'documented': [2871], 'describing': [2875], 'vivo': [2882, 4680], 'vessels': [2886], 'measuring': [2892, 3052, 3759], 'responses': [2894], '(proliferation,': [2895], 'migration)': [2896], '20Hernandez': [2962], '27Ziche': [2989], 'Jones': [2991], 'Gullino': [2993], 'P.M.': [2994], 'Inst.': [2998], '1982;': [2999], '475-482PubMed': [3001], '28Kamiyama': [3004], 'Yang': [3008], 'DeBusk': [3010], 'L.M.': [3011, 4915], 'R.M.': [3013], 'P.C.': [3015], '25:': [3018], '7019-7028Crossref': [3019], '(104)': [3022], 'focuses': [3027], 'underlying': [3031], 'exerted': [3035, 4751], 'cells.': [3042, 4443, 4721, 5386], 'First,': [3043], 'chemotactic': [3047], 'incubation': [3056, 3440, 4575], 'quiescent': [3058], 'concentrations': [3063, 5415], '(1-1000': [3067], 'h).': [3071], 'observed': [3073, 3535, 5173], 'concentration-related,': [3078], 'maximal': [3079, 4466], 'effect': [3080, 3100, 3288, 3985, 4409, 4519], 'reached': [3082], '(a': [3086], 'throughout': [3089], 'work).': [3091], 'Misoprostol,': [3092], 'metabolically': [3094], 'stable': [3095, 3109], 'reproduced': [3098], 'natural': [3103, 3538, 4794], 'ligand,': [3104, 4795], 'suggesting': [3105, 4100], 'under': [3110], 'conditions': [3112], 'used,': [3113], 'may': [3117], 'attributed': [3120], 'derivative': [3123], 'products': [3124], '(Fig.': [3125, 3196, 3256, 3276, 3441, 3528, 3541, 3594, 3643, 3744, 3808, 3896, 3963, 4036, 4080, 4098, 4154, 4387, 4496, 4523, 4535], '1A).': [3126], 'light': [3128], 'these': [3130, 3351, 5577], 'results': [3131, 5235, 5258], 'wondered': [3133], 'whether': [3134, 3390, 3615, 3717, 3725, 3993, 4129], 'might': [3137, 3825, 3845, 3905, 5526], 'involve': [3138], 'canonical': [3139], 'pathways': [3140, 5480, 5585], 'those': [3145], 'elicited': [3146, 4427], 'VEGF.': [3152], 'We,': [3153], 'therefore,': [3154], 'presence': [3161, 3764, 3957], 'antagonists': [3163], 'respective': [3166], '(FGFR-1': [3168], 'VEGFR-2).': [3170], 'abolished': [3178, 3272, 4821, 5136], 'whereas': [3181, 3279, 4156], 'application': [3182, 4455], 'SU5614': [3184], 'blocker': [3188], 'VEGFR-2,': [3190], 'modify': [3193], '1B).': [3197], 'aorta': [3207, 3238], 'explants,': [3208, 4699], 'organ': [3211, 4698], 'representing': [3213, 4417], 'integrated': [3215], 'assessing': [3218], 'As': [3220, 3558], 'shown': [3221, 3559, 3660, 4547], 'Fig.': [3223, 3561], 'rich': [3231], 'network': [3232], 'explants.': [3239], 'magnitude': [3241], 'comparable': [3247], 'promoted': [3250, 3513, 3734, 4445, 4768], 'A,': [3258], 'B,': [3259], 'C,': [3260], 'F).': [3262], 'tyrosine': [3269, 3487, 4654, 4967], 'inhibitor,': [3271, 3283, 3770, 4515], 'D-F),': [3278], 'devoid': [3285, 4160], 'any': [3287], '(not': [3289, 3432, 4605], 'shown).': [3290, 3349], 'investigate': [3292, 4705], 'selectivity': [3294], 'explants': [3302], 'thromboxane-A': [3311], 'PGI2': [3313], '(U4699': [3315], 'Iloprost': [3317, 3322], 'nm,': [3320], 'respectively).': [3321], 'induced': [3323, 3420, 3996], 'structures,': [3328], 'unaffected': [3331], 'inhibition,': [3334], 'whereasU4699': [3335], 'able': [3338, 4136], 'promote': [3340, 3591, 4046], 'neovessel': [3341], 'model': [3346, 4298, 4331], '(data': [3347], 'Collectively,': [3350], 'findings': [3352], 'clearly': [3353, 3584, 4168, 5149], 'indicate': [3354], 'selectively': [3358, 5436], 'conveys': [3359], 'mitogenic': [3361], 'endothelium,': [3366], 'migratory': [3371], 'behavior.': [3372], 'Promotes': [3374, 4114], 'Activation—To': [3376], 'determine': [3377, 3843], 'direct': [3379], 'above': [3385, 4488], 'responses,': [3387], 'could': [3392], 'stimulate': [3393], 'phosphorylation.': [3395, 4126, 4511, 4765, 5047, 5169], 'Activation': [3396, 3603], 'immunoprecipitation': [3403], 'followed': [3407], 'blotting': [3410], 'phosphotyrosine-specific': [3413], 'antibody.': [3414], 'treatment': [3416], 'rapid': [3421, 4648], '(2-fold': [3424, 4468], 'over': [3426, 3460, 3740, 4470], 'basal),': [3427], 'detectable': [3428], 'within': [3429, 3514], 'shown)': [3433], 'sustained': [3435], '3A).': [3442], 'fully': [3446, 3889], 'competent': [3447], 'slightly': [3454], 'more': [3455, 4169, 4308], 'intense': [3456, 4530], '(3-fold': [3459], 'basal).': [3461], 'confirmed': [3463], 'finding': [3465, 4725, 5039], 'approach.': [3470], 'studied': [3472, 4118], 'perinuclear': [3474, 3526, 3572, 4784], 'translocation': [3475, 3518], '(29Sorensen': [3491], 'V.': [3492], 'Nilsen': [3493], 'Wiedlocha': [3495], 'BioEssays.': [3497], '28:': [3499], '504-514Crossref': [3500], '(98)': [3503], 'addition': [3507], 'minutes': [3515], '(15': [3516, 3887, 4029], 'min)': [3517, 3888, 4025], 'membrane/cytoplasm': [3523], '3C),': [3529], 'reproducing': [3531], 'ligand': [3539], '3D).': [3542], 'better': [3544], 'analyze': [3545], 'phenomenon': [3547], 'microscopy': [3551], 'nuclear': [3554, 5203], 'marker': [3555], '(propidium': [3556], 'iodide).': [3557], '3E,': [3562], 'resulted': [3566, 4273], '(see': [3574, 4299], 'panel': [3575], '3': [3576], 'versus': [3577], '9).': [3580], 'specific,': [3585], 'failed': [3589, 3638, 4841], '3F).': [3595], 'Phosphorylation': [3596, 4401], 'Requires': [3601], 'c-Src—To': [3605], 'delineate': [3606], 'activation,': [3611, 4219, 5206, 5367], 'first': [3613], 'would': [3617], 'bind': [3619], 'CHO': [3625], 'overexpressing': [3627], 'lacking': [3630], 'receptors.': [3632, 4195], 'Exposure': [3633], 'CHO/FGFR-1': [3635], '4A).': [3644], 'Because': [3645, 3777, 4031, 4839], 'reported': [3649], 'serve': [3662], 'downstream': [3668, 4186, 4207, 5215], 'upstream': [3670, 3729, 3801, 4508], '(7Buchanan': [3676], '30Bromann': [3700], 'P.A.': [3701], 'Korkaya': [3702], 'Courtneidge': [3704], 'S.A.': [3705], '23:': [3708], '7957-7968Crossref': [3709], '(386)': [3712, 4929], 'Scholar),': [3714, 5103], 'determined': [3716], 'lies': [3728, 5214], 'robust': [3736], '(nearly': [3737], '4-fold': [3738], 'basal)': [3741, 4471], '4B).': [3745], 'influence': [3750], 'PP1,': [3766, 5231], 'comparison': [3772], 'SU5402.': [3776, 4826], 'compounds': [3779], 'inhibited': [3780, 5032], 'extent,': [3786], 'conclude': [3788], 'c-Src-dependent': [3795], '4C).': [3809], 'Activates': [3811], 'Mobilization': [3816], 'Mechanism—We': [3817], 'possibility': [3821, 3902], 'act': [3826, 4878], 'shedding': [3830, 5105], 'sequential': [3835], 'metalloproteinases.': [3841], 'whetherFGF-2': [3844], 'non-permeant': [3859], 'Application': [3874], 'challenge': [3884, 4028], 'prevented': [3890], '5A).': [3897], 'explored': [3900], 'displace': [3906, 5178], 'storage': [3910, 3979, 5114, 5159], 'sites': [3911, 5160], 'disrupting': [3913], 'heparin': [3917], 'membranes': [3920], '(31Presta': [3921], "Dell'Era": [3923], 'Mitola': [3925], 'Moroni': [3927], 'Ronca': [3929], 'Cytokine': [3933], 'Growth': [3934], 'Factor': [3935], 'Rev.': [3936], '16:': [3938], '159-178Crossref': [3939], '(1057)': [3942], 'observation': [3946], 'heparin-coated': [3951, 5181], 'unperturbed': [3954], 'negates': [3960], 'hypothesis': [3962], '5B)': [3964], 'indicates': [3966], 'does': [3969, 4341], 'affect': [3972, 4384], 'site.': [3980], 'reveal': [3982], 'mechanistic': [3984], 'shedding,': [3990], 'MMP': [4000, 4005, 4019, 4043, 4067, 5036, 5042, 5055], 'activation.': [4001, 4231, 4859, 5023], 'relevance': [4003, 4610], 'potent': [4018, 5035], '(GM6001': [4021], 'μm,': [4023, 4089], 'min).': [4030], 'suppressed': [4033, 4247], '5C),': [4037], 'deduce': [4039], 'stores.': [4053], 'mobilized-FGF-2': [4055], 'promotes': [4056, 4077, 4832, 5167, 5363, 5437], 'system.': [4062], 'identified': [4065], 'mobilization.': [4071], 'Zymography': [4072], 'production/activation': [4079], '5D).': [4081], 'pretreatment)': [4093], 'significantly': [4094], '5E),': [4099], 'player': [4107], 'shedding.': [4110], 'Receptor': [4112], 'Subtype': [4113], 'Phosphorylation—We': [4116], 'individual': [4133], 'Stimulation': [4140, 4371], 'EP1/3,': [4144], 'EP3/1,': [4145], 'EP3/4': [4147], 'consistent': [4150], '6A),': [4155], 'agonist': [4158], 'effect.': [4162, 5059], 'extent': [4164], 'marked': [4170], 'activating': [4173], 'receptor.': [4175], 'Given': [4176], 'limited': [4178, 5491], 'discriminative': [4179], 'agonists,': [4183], 'targeted': [4185], 'secondary': [4187], 'messengers': [4188], 'each': [4193], 'Accordingly,': [4196], 'block': [4204], 'protein': [4206], 'analogue': [4210, 4235], 'mimic': [4214, 4228], 'calcium': [4223, 4237], 'ionophore': [4224, 4238], 'ng/ml),': [4226], 'EP1/3': [4230], 'phosphorylating': [4249], 'ability,': [4250], 'indicating': [4251, 4555, 4607, 5150], 'predominant': [4257], 'Transfection': [4265], 'all': [4267], 'subtypes': [4270], 'EPs': [4275], 'allow': [4280], 'monitoring': [4281], 'transactivation': [4284], 'absence': [4291], 'supplemental': [4300], 'Figs.': [4301], 'S1': [4302], 'S2).': [4304], 'address': [4307], 'specifically': [4309], 'selected,': [4327], 'capability': [4334], 'expressing': [4336], 'express': [4343], '(32Dormond': [4347], 'O.': [4348], 'Bezzi': [4349], 'Mariotti': [4351], 'Ruegg': [4353], '277:': [4359], '45838-45846Abstract': [4360], '(145)': [4368], '6C),': [4388], 'demonstrating': [4389], 'responsible': [4395], 'endothelium.': [4400, 4641], 'PGE2—We': [4405], 'next': [4406], 'terminal': [4419], 'molecule': [4420, 4637], 'nucleus': [4425], 'FGF-2;': [4433], 'hence,': [4434], 'closely': [4436], 'associated': [4437], 'events': [4440, 4957, 5379], 'early': [4449], '(both': [4459], 'origin),': [4464], 'reaching': [4465], 'incubation.': [4476], '(FGFR-1)': [4492], '(c-Src)': [4495], '7,': [4497], 'B),': [4500], 'establishing': [4501], 'lie': [4507], 'Conversely,': [4512], 'exhibited': [4517], 'no': [4518], '7C).': [4524], 'Note': [4525], 'detection': [4528], 'HMVEC-C': [4534], '7D)': [4536], 'dependence': [4543], 'blockade,': [4554], 'existence': [4557, 5144], 'diverse': [4568], 'lineage': [4569, 5244], 'origin.': [4573, 5267], 'Furthermore,': [4574], 'EC': [4577], 'above,': [4585], '(MMPs),': [4589], '(c-Src),': [4591], '(ERK1/2),': [4594], 'migrate': [4600], 'shown),': [4606], 'c-Src/MMP/FGFR-1': [4613], 'activity.': [4621], 'describes': [4624], 'factor-2,': [4661], 'ex': [4679], 'studies.': [4681], 'cells,': [4690, 4758, 5009, 5618], 'except': [4691], 'few': [4693], 'because': [4700], 'our': [4701, 4934], 'aim': [4702], 'avoiding': [4708], 'interference': [4710], 'types,': [4714], 'tumor,': [4717], 'stromal,': [4718], 'inflammatory': [4720, 5423], 'significant': [4724], 'concerns': [4729], 'key': [4731], 'stimulatory': [4739], 'neovascularization.': [4749], 'concentration-related': [4753], 'chemoattractant': [4754], 'toward': [4756], 'stringently': [4761], 'dependent': [4762], 'internalization,': [4770], 'revealed': [4772, 4835], 'immunohistochemistry': [4774], 'enrichment': [4781], 'area,': [4785], 'feature': [4787], 'typical': [4788], 'FGF-2.': [4796], 'Further': [4797], 'prerequisite': [4804], 'promptly': [4820], 'unforeseen': [4837], 'complexity.': [4838], 'interact': [4843], 'thought': [4851], 'indirect': [4854], 'route': [4855], 'Analogous': [4860], 'recently': [4864], 'systems': [4868], 'β-adrenergic': [4871], 'endothelin': [4873], 'receptors),': [4874], 'like': [4876], '(33Daub': [4883], 'Weiss': [4885], 'F.U.': [4886], 'Wallasch': [4887], 'Nature.': [4891], '1996;': [4892], '379:': [4893], '557-560Crossref': [4894], '(1329)': [4897], '34Maudsley': [4900], 'Pierce': [4902], 'K.L.': [4903], 'Zamah': [4904], 'A.M.': [4905], 'Miller': [4906], 'W.E.': [4907], 'Ahn': [4908], 'Daaka': [4910], 'Lefkowitz': [4912], 'R.J.': [4913], 'Luttrell': [4914], '2000;': [4919], '275:': [4920], '9572-9580Abstract': [4921], 'focused': [4933], 'attention': [4935], 'MMPs': [4939], 'possible': [4941], 'between': [4944], 'rationale': [4949], 'intracellular-extracellular': [4956], 'operant': [4963], 'strongly': [5003], '(PP1),': [5020], 'abrogated': [5021], 'applying': [5034], 'blockers,': [5037], 'implicates': [5041], 'Additional': [5048], 'characterization': [5049], 'These': [5060], 'membrane-bound': [5061], 'proteases,': [5062], 'possibly': [5067, 5247], 'MT-MMP1': [5073], '(35Nyalendo': [5074], 'Michaud': [5076], 'Beaulieu': [5078], 'Roghi': [5080], 'Gingras': [5084], 'Beliveau': [5086], '15690-15699Abstract': [5093], '(110)': [5101], 'chemokines': [5110], 'membrane-embedded': [5113], 'sites,': [5115], 'exemplified': [5117], 'EGFR': [5119], 'released': [5123], 'glycoprotein': [5126], 'storage.': [5127], 'antibody,': [5134], 'illustrate': [5142], 'mechanism,': [5148], 'activated': [5152], 'mobilized': [5154], 'and,': [5161], 'turn,': [5163], 'addition,': [5171], 'failure': [5174], 'highlights': [5183], 'nature': [5186], 'controlled': [5195], 'signals.': [5198], 'nearest': [5202], 'transcription': [5204], 'vigorously': [5208], 'phosphorylated': [5209], 'here': [5219], 'examined,': [5220], 'GM6001.': [5233], 'PGE2-mediated': [5237], 'extend': [5239], 'origin,': [5246], 'endothelium': [5251], 'general,': [5253], 'HMVEC-C,': [5261], 'arterial': [5266], 'Both': [5268], 'implicated': [5275], '19Kamoshita': [5312], 'Our': [5352], 'suggests': [5354], 'MMP2': [5366], 'subsequent': [5374], 'internalization.': [5375], 'triggers': [5380], 'lack': [5388], 'represents': [5402], 'interesting': [5404], 'finding.': [5405], 'Clearly,': [5406], 'pertains': [5420], 'process,': [5424], 'distinct': [5430], 'patterns.': [5432], 'particular,': [5434], 'endogenous': [5441, 5624], 'transduction': [5443], 'pathway,': [5444], 'FGF-2/FGFR-1,': [5445], 'manner': [5451, 5466], 'control': [5453], 'On': [5456], 'contrary,': [5458], 'VEGF/VEGFR-2': [5460], 'paracrine': [5465], 'independent': [5471, 5584], 'stromal': [5476], 'components.': [5477], 'share': [5481], 'common': [5485], 'requirement,': [5486], 'permeability': [5495], '(36Eliceiri': [5497], 'B.P.': [5498], 'Puente': [5499], 'X.S.': [5500], 'Hood': [5501], 'J.D.': [5502], 'Stupack': [5503], 'D.G.': [5504], 'Schlaepfer': [5505], 'D.D.': [5506], 'Huang': [5507], 'X.Z.': [5508], 'Sheppard': [5509], 'Cheresh': [5511], 'D.A.': [5512], '157:': [5517], '149-160Crossref': [5518], '(301)': [5521], 'Conceivably,': [5524], 'appropriate': [5529], 'target': [5530], 'interventions': [5533], 'reducing': [5536], 'pathological': [5537, 5588], 'excess': [5544], 'occurs': [5550], 'tumors.': [5553], 'current': [5558], 'strategy': [5559], 'targeting': [5561], 'single': [5562], 'mediators': [5563], 'antibodies)': [5567], 'recorded': [5569], 'emergence': [5571], 'resistance': [5573], 'escape': [5575], 'interventions,': [5578], 'reinforcing': [5579], 'multiple': [5583], 'contribute': [5586], 'particularly': [5590], 'malignancy': [5592], 'often': [5593], 'coexistence': [5597], 'exerts': [5606], 'recruiting': [5611], 'paracrineautocrine': [5613], 'characteristic': [5615], 'i.e.': [5619], 'FGF-2,': [5625], 'supports': [5627], 'remodeling.': [5629], 'thank': [5631], 'Missouri-Rolla': [5635], '(UMR),': [5636], 'Center': [5639], 'plasmids.': [5646], 'Download': [5647], '.pdf': [5648], '(.06': [5649], 'MB)': [5650], 'Help': [5651], 'pdf': [5653], 'files': [5654]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2067652148', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2023, 'cited_by_count': 2}, {'year': 2022, 'cited_by_count': 8}, {'year': 2021, 'cited_by_count': 8}, {'year': 2020, 'cited_by_count': 11}, {'year': 2019, 'cited_by_count': 7}, {'year': 2018, 'cited_by_count': 9}, {'year': 2017, 'cited_by_count': 8}, {'year': 2016, 'cited_by_count': 7}, {'year': 2015, 'cited_by_count': 10}, {'year': 2014, 'cited_by_count': 2}, {'year': 2013, 'cited_by_count': 8}, {'year': 2012, 'cited_by_count': 6}], 'updated_date': '2024-12-15T23:31:48.605636', 'created_date': '2016-06-24'}
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