Title: Effect of phenobarbital on the excretion of an exogenous bilirubin load
Abstract: Treatment of mice with phenobarbital significantly enhanced the disappearance of exogenously administered bilirubin from the plasma. Not only did this enhanced disappearance occur in the absence of biliary excretion but it was accompanied by liver bilirubin concentrations exceeding those found in controls. Both observations suggest enhanced uptake of free bilirubin by the liver as one cause of the faster rate of disappearance of bilirubin from plasma. In rats, the maximal rate of bilirubin excretion was enhanced by treatment with phenobarbital. The bile volume was also greater in phenobarbital-treated animals than in controls. The concentration of bilirubin in the bile was not significantly different, indicating that the increase in bilirubin excretion was probably due to the increase in bile volume. Indirectly, some of the data suggest that increased bilirubin conjugation may play a role in the enhanced uptake and excretion of bilirubin after phenobarbital treatment.
Publication Year: 1967
Publication Date: 1967-05-01
Language: en
Type: article
Indexed In: ['crossref', 'pubmed']
Access and Citation
Cited By Count: 114
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