NFκB Activation Is Required for the Neuroprotective Effects of Pigment Epithelium-derived Factor (PEDF) on Cerebellar Granule Neurons

Name: Work Video:
Duration: 3 min 30 s
Takeshi Yabe; Delores Wilson; Joan P. Schwartz
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[32, 244], 'Because': [33, 245, 3944], 'the': [34, 47, 76, 108, 112, 120, 137, 151, 246, 259, 288, 320, 324, 332, 349, 363, 499, 856, 885, 920, 947, 1477, 1483, 1581, 1591, 1637, 1686, 1696, 1705, 1754, 1824, 1876, 1916, 1933, 1969, 1997, 2020, 2033, 2091, 2221, 2316, 2345, 2360, 2382, 2486, 2493, 2506, 2519, 2562, 2569, 2623, 2626, 2643, 2655, 2692, 2709, 2729, 2783, 2795, 2799, 2805, 2859, 2952, 3154, 3160, 3207, 3218, 3273, 3279, 3300, 3303, 3330, 3343, 3349, 3358, 3361, 3366, 3381, 3388, 3404, 3427, 3433, 3459, 3467, 3484, 3584, 3675, 3695, 3746, 3919, 3927, 3937, 4022, 4052, 4094, 4109, 4186, 4192, 4201, 4214, 4221, 4256, 4263, 4267, 4302], 'transcription': [35, 247, 462, 937, 948], 'NFκB': [37, 56, 133, 249, 268, 345, 950, 1296, 1461, 1481, 1937, 2948, 2955, 3037, 3068, 3120, 3144, 3161, 3179, 3202, 3280, 3290, 3304, 3350, 3422, 3465, 3474, 3566, 3588, 3687, 3702, 3776, 4007, 4234, 4250], 'blocks': [38, 126, 250, 338], 'cell': [39, 251, 576, 912, 921, 1827, 2237, 2376, 2508, 2563, 3535, 3920], 'death,': [40, 252, 3936], 'including': [41, 253, 539, 964], 'neuronal': [42, 195, 254, 407, 957, 1467, 3741, 3889], 'apoptosis,': [43, 255], 'we': [44, 256, 1474, 2579, 3309, 3482, 3922], 'have': [45, 257, 1475, 3923], 'investigated': [46, 258], 'ability': [48, 260, 3676], 'of': [49, 63, 67, 72, 83, 96, 110, 122, 129, 140, 150, 171, 199, 206, 261, 275, 279, 284, 295, 308, 322, 334, 341, 352, 362, 383, 411, 418, 498, 524, 533, 858, 887, 899, 911, 924, 936, 946, 962, 1223, 1295, 1299, 1480, 1486, 1616, 1627, 1631, 1681, 1685, 1699, 1711, 1819, 1830, 1923, 1992, 2006, 2126, 2168, 2205, 2336, 2480, 2488, 2496, 2592, 2615, 2635, 2660, 2672, 2694, 2719, 2753, 2757, 2775, 2794, 2807, 2813, 2866, 2935, 2954, 2983, 3119, 3129, 3138, 3142, 3159, 3167, 3174, 3211, 3235, 3240, 3302, 3332, 3341, 3348, 3360, 3397, 3432, 3436, 3445, 3461, 3464, 3473, 3487, 3518, 3537, 3587, 3677, 3701, 3763, 4001, 4013, 4017, 4024, 4051, 4060, 4088, 4096, 4111, 4204, 4258], 'PEDF': [50, 58, 97, 193, 262, 270, 309, 405, 525, 569, 749, 841, 890, 1537, 1583, 1638, 1682, 1700, 2946, 2970, 3087, 3113, 3132, 3187, 3255, 3476, 3503, 3678, 3739, 3754, 3945, 4089, 4112, 4142, 4205], 'to': [51, 75, 263, 287, 889, 1621, 1915, 2257, 2308, 2381, 2568, 2601, 2622, 2665, 2678, 2685, 2708, 2724, 2742, 2782, 2804, 2957, 2980, 2987, 3272, 3278, 3354, 3416, 3443, 3466, 3679, 3707, 3723, 3772, 3810, 3933, 4003, 4043, 4175], 'exert': [52, 264], 'effects': [54, 95, 139, 266, 307, 351, 572, 752, 1485, 4016, 4242, 4300], 'via': [55, 267, 3694], 'activation.': [57, 269], 'an': [60, 272, 1463, 3337], 'increased': [61, 273, 3071, 3409], 'phosphorylation': [62, 121, 274, 333, 3517, 3556, 3691], 'IκBα,': [64, 276, 1513, 2290], 'decreased': [65, 277], 'levels': [66, 278, 1691, 3532], 'IκB': [68, 113, 280, 325, 1131, 1300, 3434, 3448, 3478, 3488, 3555, 3578, 3629, 3690, 4025, 4215], 'proteins,': [69, 281], 'translocation': [71, 283, 3460, 3586, 3710], 'p65': [73, 285, 1507, 2294, 2356, 3355, 3531, 3732, 3747], '(RelA)': [74, 286, 3356], 'nucleus': [77, 289], 'followed': [78, 290, 2132], 'by': [79, 107, 291, 319, 488, 1297, 1753, 1880, 1948, 1986, 2062, 2133, 2225, 2266, 2370, 2492, 2647, 2932, 3178, 3285, 3307, 3429, 3475, 3480, 3775, 3940, 4070, 4077, 4093, 4213], 'a': [80, 292, 480, 496, 530, 909, 952, 960, 1574, 1628, 1750, 1806, 1816, 1881, 1907, 1976, 1989, 2099, 2124, 2146, 2151, 2258, 2334, 2454, 2524, 2550, 2581, 2666, 2750, 2976, 3080, 3126, 3139, 3430, 3505, 3544, 3941, 4078], 'time-dependent': [81, 293, 3506], 'increase': [82, 294], 'NFκB-DNA': [84, 296, 3382], 'binding': [85, 297, 1938, 1999, 2021, 2263, 2956, 3038, 3069, 3121, 3155, 3162], 'activity': [86, 298, 1642, 2575, 3070, 3122, 3163, 3580, 4008, 4235], 'both': [88, 99, 300, 311, 3318, 3342, 3509, 3758, 3885, 3950, 4012, 4185, 4244, 4262], 'neurons.': [92, 169, 188, 304, 381, 400, 3170, 3322], 'The': [93, 305, 914, 1536, 1625, 1940, 2141, 2159, 2421, 2478, 2633, 2737, 2745, 2786, 2836, 2863, 3136, 4085], 'protective': [94, 306], 'toxicity': [104, 316, 818, 966, 1051, 3882, 3976, 4208], 'were': [105, 317, 1492, 1499, 1516, 1717, 1762, 1878, 1926, 1943, 1971, 1984, 2008, 2029, 2053, 2071, 2096, 2116, 2143, 2161, 2254, 2295, 2318, 2342, 2357, 2390, 2404, 2423, 2439, 2460, 2473, 2521, 2619, 2628, 2663, 2676, 2722, 2839, 2930, 3040, 3053, 3184, 3197, 3252, 3263, 3540, 3562, 3569, 3717, 3743, 4041, 4054, 4168, 4173], 'blocked': [106, 318, 844, 4092, 4212], 'addition': [109, 321, 1626, 3137, 3331, 4095, 4110], 'either': [111, 323, 3670, 4097], 'kinase': [114, 326, 3579, 4026, 4216], 'inhibitor': [115, 327, 502, 3624], 'BAY': [116, 328, 1488, 3574, 4102, 4158], '11-7082,': [117, 329, 3575], 'which': [118, 125, 201, 330, 337, 413, 3194, 3576, 3626, 3768], 'inhibits': [119, 331, 3577, 3583], 'IκB,': [123, 130, 335, 342], 'orN-acetyl-Leu-Leu-norleucinal,': [124, 336], 'proteosome': [127, 339, 1304, 3623, 4028, 4218], 'degradation': [128, 340, 3479, 3693], 'demonstrating': [131, 343], 'that': [132, 148, 192, 344, 360, 404, 568, 884, 918, 944, 1460, 2792, 3067, 3387, 3554, 3560, 3685, 3753, 3925, 4200, 4232, 4295], 'required': [135, 347, 3558, 4010], 'for': [136, 154, 348, 366, 1683, 1875, 2013, 2067, 2084, 2111, 2216, 2230, 2284, 2320, 2395, 2416, 2433, 2446, 2475, 2527, 2630, 2683, 2712, 2819, 2826, 2834, 3107, 3190, 3201, 3258, 3267, 3731, 4011, 4179], 'neuroprotective': [138, 350, 1484, 4015, 4086, 4202, 4241], 'PEDF.': [141, 353, 1487, 2969, 3244, 4018, 4084], 'Reverse': [142, 354], 'transcription-polymerase': [143, 355], 'chain': [144, 356, 464], 'reaction': [145, 357, 465, 2428], 'analysis': [146, 358, 2934, 3313, 3751], 'revealed': [147, 359, 3752, 4199], 'up-regulation': [149, 361], 'anti-apoptotic': [152, 207, 364, 419, 4299], 'genes': [153, 365, 4260, 4294], 'Bcl-2,': [155, 367, 2900], 'Bcl-x,': [156, 368], 'manganese': [158, 370], 'superoxide': [159, 371, 446], 'dismutase': [160, 372, 447, 2912], 'was': [161, 184, 373, 396, 527, 1529, 1542, 1585, 1619, 1811, 1904, 2223, 2239, 2264, 2368, 2451, 2483, 2503, 2597, 2638, 2696, 2703, 2740, 2789, 2797, 2856, 2959, 2971, 3096, 3105, 3123, 3282, 3407, 3521, 3557, 3705, 3733, 4000, 4073, 4090, 4209], 'observed': [162, 374, 3083, 3097, 3124, 3522], 'PEDF-treated': [164, 376, 3389, 3491, 3524, 3538, 3715], 'not': [167, 379, 782, 1634, 3147, 3378, 3541, 4144, 4153], 'Up-regulation': [170, 382], 'nerve': [172, 384, 466, 1105, 2872], 'growth': [173, 385, 467, 2873], 'factor,': [174, 177, 386, 389], 'brain-derived': [175, 387, 469, 2881], 'neurotrophic': [176, 181, 209, 388, 393, 421, 470, 474, 571, 925, 2882, 2892], 'glial': [179, 391, 472, 2890], 'cell-derived': [180, 392, 473, 2891], 'mRNA': [183, 395, 526, 3765], 'long-lasting': [185, 397], 'These': [189, 401, 881, 1457, 3384, 3682, 4229], 'results': [190, 402, 3683, 4167, 4230], 'suggest': [191, 403, 883, 1459, 3386, 3684, 4231], 'promotes': [194, 406, 1306], 'survival': [196, 408, 1468, 2502, 4162], 'through': [197, 409, 1950], 'activation': [198, 410, 935, 945, 3472, 3688, 3700], 'NFκB,': [200, 412, 2038, 3219, 3446], 'turn': [203, 415], 'induces': [204, 416, 3755], 'expression': [205, 417, 907, 1577, 3485, 3756, 4257], 'and/or': [208, 420], 'genes.': [211, 423], 'pigment': [424, 492], 'daysin': [430], 'vitro': [431, 758], 'electrophoresis': [432, 1949, 2847], 'mobility': [433], 'shift': [434], 'assay': [435, 2372, 2510, 2609, 2674, 4188, 4195], 'Tris-buffered': [436], 'saline': [437, 2059, 2273], 'with': [438, 1303, 1636, 1770, 1834, 1842, 1852, 1906, 1928, 1988, 2010, 2057, 2118, 2150, 2274, 2323, 2344, 2359, 2426, 2441, 2505, 2530, 2802, 2841, 2966, 3079, 3186, 3243, 3254, 3270, 3380, 3571, 3620, 3628, 3669, 3721, 3745, 4081, 4298], 'Tween': [439, 2276], '20': [440, 2172, 2217, 2269, 2277], '3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium,': [441], 'inner': [442, 2534], 'salt': [443], 'lactate': [444], 'dehydrogenase': [445], 'tumor': [448], 'necrosis': [449], 'TNF-related': [451], 'apoptosis-inducing': [452], 'ligand': [453], 'cAMP-response': [454], 'element': [455], 'N-acetyl-Leu-Leu-norleucinal': [456], 'terminal': [457], 'dUTP': [458], 'nick-end': [459], 'labeling': [460], 'reverse': [461], 'polymerase': [463, 2760, 2778], '(PEDF),1': [479], '50-kDa': [481], 'glycoprotein': [482], 'first': [483, 2725], 'isolated': [484], 'from': [485, 645, 669, 1494, 1501, 1518, 1530, 1580, 1590, 1719, 1945, 2236, 2467, 2577, 2705, 3046, 3317, 3802, 4184], 'medium': [486, 859, 1766, 1769, 2429, 2565, 2596, 2645, 2652, 2990, 3803, 3812, 4045], 'conditioned': [487], 'human': [489, 534, 1582], 'fetal': [490, 535, 1783], 'retinal': [491, 723], 'epithelial': [493], 'cells,': [494, 2557], 'member': [497, 3431], 'serine': [500], 'protease': [501, 2206], '(SERPIN)': [503], 'gene': [504, 906, 1639], 'family': [505, 3435], '(1Tombran-Tink': [506], 'J.': [507, 545, 589, 611, 631, 652, 655, 681, 684, 710, 728, 737, 761, 800, 831, 870, 990, 1011, 1039, 1061, 1164, 1189, 1211, 1235, 1282, 1326, 1398, 1556, 1561, 1651, 1669, 1739, 1863, 3005, 3025, 3596, 3603, 3872, 3963, 3989, 4131, 4278, 4318, 4349], 'Chader': [508, 556, 585, 605, 627, 772, 796, 825, 866, 1559, 1647, 1665, 1735, 1859, 2999, 3021, 3959, 3983, 4127], 'G.J.': [509, 557, 586, 606, 628, 773, 797, 826, 867, 1560, 1648, 1666, 1736, 1860, 3000, 3022, 3960, 3984, 4128], 'Johnson': [510, 1005], 'L.V.': [511], 'Exp.': [512, 686], 'Eye': [513], 'Res.': [514, 633, 657, 739, 802, 872, 1122, 1166, 1375, 1448, 1671, 1894, 3027, 3786, 3851, 3965, 4133, 4320], '1991;': [515], '53:': [516, 635, 804, 874, 3029, 3967, 4135], '411-414Crossref': [517], 'PubMed': [518, 594, 616, 637, 661, 691, 716, 743, 806, 836, 876, 975, 995, 1016, 1044, 1074, 1099, 1126, 1149, 1170, 1200, 1216, 1240, 1261, 1288, 1331, 1355, 1379, 1409, 1432, 1452, 1570, 1656, 1675, 1744, 1868, 1898, 3010, 3031, 3614, 3643, 3657, 3790, 3835, 3855, 3877, 3912, 3969, 3994, 4137, 4283, 4324, 4360], 'Scopus': [519, 595, 617, 638, 662, 692, 717, 744, 807, 837, 877, 976, 1017, 1045, 1075, 1100, 1127, 1171, 1201, 1217, 1262, 1289, 1332, 1356, 1380, 1410, 1433, 1453, 1657, 1676, 1745, 1869, 1899, 3011, 3032, 3615, 3644, 3658, 3791, 3836, 3856, 3913, 3970, 3995, 4138, 4284, 4325, 4361], '(563)': [520, 1076], 'Google': [521, 563, 597, 619, 640, 664, 694, 719, 746, 779, 809, 839, 879, 978, 996, 1019, 1047, 1077, 1102, 1129, 1150, 1173, 1203, 1219, 1241, 1264, 1291, 1334, 1358, 1382, 1412, 1435, 1455, 1571, 1659, 1678, 1747, 1871, 1901, 3013, 3034, 3617, 3646, 3660, 3793, 3838, 3858, 3878, 3915, 3972, 3997, 4140, 4286, 4327, 4363], 'Scholar).': [522, 564, 747, 840, 880, 1292, 1456, 1572, 1679, 1872, 1902, 3035, 3661, 3794, 3879, 4287], 'Expression': [523], 'detected': [528, 2343, 2358, 2369, 3041, 3054], 'broad': [531], 'range': [532, 2801, 3128], 'adult': [537], 'tissues': [538], 'almost': [540, 3338, 4074], 'all': [541, 1622, 2556], 'brain': [542], 'areas': [543], '(2Tombran-Tink': [544, 760], 'Mazuruk': [546, 762], 'K.': [547, 763, 1006, 1057, 1163, 4317], 'Rodriguez': [548, 764], 'I.R.': [549, 765], 'Chung': [550, 766], 'D.': [551, 732, 767, 983, 1055, 1275], 'Linker': [552, 768], 'T.': [553, 582, 600, 622, 624, 769, 791, 793, 820, 861, 863, 1004, 1644, 1732, 1856, 2994, 3016, 3018, 3600, 3822, 3954, 3956, 3978, 4122, 4124, 4346], 'Englander': [554, 770], 'E.': [555, 650, 707, 771, 1002, 1250, 1277, 1421, 1632, 1885, 3896], 'Mol.': [558, 774, 1255, 1426], 'Vis.': [559, 775], '1996;': [560, 776, 3640], '2:': [561, 777], '11PubMed': [562, 778], 'Later': [565], 'studies': [566, 942, 3065], 'demonstrate': [567, 3699], 'has': [570, 750, 3769], 'on': [573, 642, 666, 722, 753, 1813, 2087, 2219, 2419, 3918, 4030, 4035], 'neurons': [577, 643, 668, 724, 1226, 1309, 1832, 3390, 3412, 3418, 3492, 3762], '(CGCs)': [578], 'culture': [580, 1497, 2564, 2595, 2644], '(3Taniwaki': [581, 1643, 1731, 1855], 'Becerra': [583, 603, 625, 708, 794, 823, 864, 1645, 1663, 1733, 1857, 2997, 3019, 3957, 3981, 4125], 'S.P.': [584, 604, 626, 709, 795, 824, 865, 1548, 1646, 1664, 1734, 1858, 2998, 3020, 3958, 3982, 4126], 'Schwartz': [587, 609, 629, 798, 829, 868, 1649, 1667, 1737, 1861, 3003, 3023, 3961, 3987, 4129], 'J.P.': [588, 610, 630, 799, 830, 869, 1650, 1668, 1738, 1862, 3004, 3024, 3962, 3988, 4130], 'Neurochem.': [590, 612, 832, 1012, 1040, 1212, 1327, 1447, 1652, 1740, 1864, 3006, 3990, 4279], '1995;': [591, 1071, 1653, 1741, 1865, 3874, 3906], '64:': [592, 1654, 1742, 1866], '2509-2517Crossref': [593, 1655, 1743, 1867], '(134)': [596, 1658, 1746, 1870], 'Scholar,': [598, 620, 695, 979, 1078, 1174, 1204, 1242, 1265, 1359, 1383, 1413, 1436, 1660, 3014, 3647, 3839, 3859], '4Taniwaki': [599], 'Hirashima': [601, 821, 2995, 3979], 'N.': [602, 822, 1026, 1188, 1313, 1397, 2996, 3980], 'Etcheberrigaray': [607, 827, 3001, 3985], 'R.': [608, 734, 828, 3002, 3592, 3986], '1997;': [613, 833, 1167, 1672, 3007, 3606, 3654, 3991, 4321], '68:': [614, 834, 3008, 3992], '26-32Crossref': [615, 835, 3009, 3993], '(104)': [618, 838, 3012, 3996], '5Araki': [621, 3015], 'Taniwaki': [623, 792, 862, 3017, 3955, 4123], 'Neurosci.': [632, 656, 738, 801, 871, 991, 1165, 1236, 1257, 1428, 1670, 3026, 3873, 3964, 4132, 4319], '1998;': [634, 803, 873, 972, 1237, 3028, 3966, 4134], '7-15Crossref': [636, 805, 875, 3030, 3968, 4136], '(110)': [639, 808, 878, 3033, 3971, 4139], 'Scholar),': [641, 665, 720, 997, 1020, 1048, 1103, 1130, 1151, 1220, 3618, 3998, 4141], 'cultured': [644], 'hippocampus': [646], '(6DeCoster': [647], 'M.A.': [648], 'Schabelman': [649], 'Tombran-Tink': [651, 680, 727], 'Bazan': [653], 'N.G.': [654], '1999;': [658, 688, 713, 740, 992, 1096, 1192, 1258, 1352, 1401, 1429, 4352], '56:': [659], '604-610Crossref': [660], '(92)': [663], 'motor': [667], 'spinal': [670], 'cord': [671], '(7Bilak': [672], 'M.M.': [673, 1180, 1389, 1889], 'Corse': [674], 'A.M.': [675, 1254, 1281, 1425, 1442], 'Bilak': [676], 'S.R.': [677, 3649, 3818], 'Lehar': [678], 'M.': [679, 1024, 1038, 1082, 1244, 1269, 1311, 1325, 1338, 1415, 3845, 3892, 4334, 4348], 'Kuncl': [682], 'R.W.': [683], 'Neuropathol.': [685], 'Neurol.': [687, 712], '58:': [689], '719-728Crossref': [690], '(173)': [693], '8Houenou': [696], 'L.J.': [697], "D'Costa": [698], 'A.P.': [699], 'Li': [700], 'L.': [701], 'Turgeon': [702], 'V.L.': [703], 'Enyadike': [704], 'C.': [705, 1008, 1088, 1344, 3820, 3861], 'Alberdi': [706], 'Comp.': [711], '412:': [714], '506-514Crossref': [715], '(118)': [718, 1046, 1333], '(9Cao': [725], 'W.': [726, 730, 1161, 1891, 4315], 'Chen': [729], 'Mrazek': [731], 'Elias': [733], 'McGinnis': [735], 'J.F.': [736], '57:': [741], '789-800Crossref': [742], '(178)': [745, 3857], 'Moreover,': [748], 'differential': [751], 'CGCs,': [754, 2578], 'protecting': [755, 812], '(daysin': [757], '(DIV)': [759], 'Scholar)': [780, 810, 1748, 3916, 3973, 4328, 4364], '(DIV6)': [784], 'low': [787, 998, 2988, 4031, 4071], 'K+/serum-free-induced': [788, 4032], '(5Araki': [790, 860, 3953, 4121], 'while': [811], 'CGCs': [814, 888, 1716, 2052, 2389, 2520, 2706, 2964, 2984, 3047, 3077, 3100, 3182, 3241, 3245, 3525, 3568, 3716, 3795, 3948, 4146, 4172], '(DIV8)': [815, 3183], 'glutamate-induced': [817], '(4Taniwaki': [819, 2993, 3977], 'most': [842], 'effectively': [843], '(DIV2)': [850], 'when': [851, 3798, 4163, 4170, 4226], 'added': [852, 1597, 1620, 1812, 2621, 2677, 2972, 4164, 4227], '24': [853], 'h': [854, 2322, 2397, 2529, 3074, 3085, 3111, 3269, 3737, 4057, 4181], 'before': [855, 2019, 4108], 'change': [857], 'observations': [882, 1458], 'responses': [886], 'may': [891], 'vary': [892], 'as': [893, 908, 1544, 1728, 2030, 2485, 2640, 2858, 2870, 3226], 'neural': [894], 'differentiation': [895], 'proceeds,': [896], 'possibly': [897], 'because': [898], 'changes': [900], 'signal': [902, 915], 'transduction': [903, 916], 'pathways': [904, 917], 'or': [905, 1301, 1793, 1920, 1936, 2328, 2967, 2991, 3150, 3209, 3222, 3375, 3619, 3672, 3714, 4101], 'function': [910], 'maturity.': [913], 'mediate': [919], 'survival-promoting': [922], 'actions': [923], 'factors': [926, 938], 'are': [927, 2869, 3441, 3800, 4296], 'being': [928], 'worked': [929], 'out,': [930], 'many': [933], 'cases': [934], 'involved.': [940], 'Recent': [941], 'show': [943, 3708], 'plays': [951, 1462, 4251], 'critical': [953], 'role': [954, 1465, 1479], 'preventing': [956], 'death': [958, 1222, 2377, 2982, 3890, 3938, 4062, 4068], 'number': [961, 2487, 2495, 2788], 'models,': [963], '(10Mao': [967], 'X.': [968], 'Barger': [969], 'S.W.': [970, 1053], 'Neuroreport.': [971], '9:': [973], '759-763Crossref': [974], '(103)': [977], '11Yu': [980], 'Z.': [981, 4275], 'Zhou': [982], 'Bruce-Keller': [984], 'A.J.': [985], 'Kindy': [986], 'M.S.': [987], 'Mattson': [988, 1062, 1209, 4305], 'M.P.': [989, 1034, 1063, 1155, 1210, 1321, 4271, 4309], '19:': [993], '8856-8865Crossref': [994], 'K+-induced': [999], '(12Koulich': [1001], 'Nguyen': [1003], 'Giardina': [1007], "D'Mello": [1009], 'S.': [1010, 1032, 1069, 1094, 1139, 1208, 1232, 1248, 1273, 1319, 1350, 1419, 3830, 3900, 4277, 4340, 4344], '2001;': [1013], '76:': [1014], '1188-1198Crossref': [1015], '(99)': [1018], 'hypoxia/reoxygenation-induced': [1021], '(13Tamatani': [1023, 1310], 'Mitsuda': [1025, 1312], 'Matsuzaki': [1027, 1314, 4337], 'H.': [1028, 1030, 1084, 1159, 1315, 1317, 1340, 4313, 4338, 4342], 'Okado': [1029, 1316, 4341], 'Miyake': [1031, 1318, 4343], 'Vitek': [1033, 1320], 'Yamaguchi': [1035, 1322], 'A.': [1036, 1070, 1095, 1141, 1323, 1351, 1552, 3651, 3831, 3865], 'Tohyama': [1037, 1324, 4347], '2000;': [1041, 1123, 1146, 1213, 1285, 1328, 1376, 1449, 4280], '75:': [1042, 1214, 1329], '683-686Crossref': [1043, 1330], 'β-amyloid': [1049], 'peptide-induced': [1050], '(14Barger': [1052], 'Horster': [1054], 'Furukawa': [1056, 1162, 4316], 'Goodman': [1058, 1156, 4310], 'Y.': [1059, 1157, 1271, 1662, 4311], 'Krieglstein': [1060], 'Proc.': [1064, 1089, 1345, 3825], 'Natl.': [1065, 1090, 1346, 3826], 'Acad.': [1066, 1091, 1347, 3827], 'Sci.': [1067, 1092, 1348, 3828], 'U.': [1068, 1093, 1349, 3829], '92:': [1072], '9328-9332Crossref': [1073], '15Kaltschmidt': [1079], 'B.': [1080, 1086, 1336, 1342, 3843, 3898], 'Uherek': [1081, 1337], 'Wellmann': [1083, 1339], 'Volk': [1085, 1341], 'Kaltschmidt': [1087, 1343], '96:': [1097, 1353], '9409-9414Crossref': [1098, 1354], '(278)': [1101, 1357], 'optic': [1104], 'transection': [1106], '(16Choi': [1107], 'J.S.': [1108, 1361], 'Kim': [1109, 1111, 1362, 1364], 'J.A.': [1110, 1363], 'D.H.': [1112, 1365], 'Chun': [1113, 1366], 'M.H.': [1114, 1367], 'Gwag': [1115, 1368], 'B.J.': [1116, 1369], 'Yoon': [1117, 1370], 'S.K.': [1118, 1182, 1371, 1391], 'Joo': [1119, 1372], 'C.K.': [1120, 1373], 'Brain': [1121, 1374, 3850], '883:': [1124, 1377], '60-68Crossref': [1125, 1378], '(47)': [1128, 1381], 'kinase-deficient': [1132], 'mice': [1133], '(17Li': [1134], 'Q.': [1135], 'Estepa': [1136], 'G.': [1137, 1246, 1267, 1417, 3594, 3871], 'Memet': [1138], 'Israel': [1140], 'Verma': [1142], 'I.M.': [1143], 'Genes': [1144], 'Dev.': [1145], '14:': [1147, 1259, 1430], '1729-1733Crossref': [1148], 'oxidative': [1152], 'stress': [1153], '(18Mattson': [1154, 4308], 'Luo': [1158, 4312], 'Fu': [1160, 4314], '49:': [1168, 1673, 4322], '681-697Crossref': [1169, 4323], '(524)': [1172, 4326], '19Krishnamoorthy': [1175, 1384], 'R.R.': [1176, 1385], 'Crawford': [1177, 1386], 'M.J.': [1178, 1387], 'Chaturvedi': [1179, 1388], 'Jain': [1181, 1390], 'Aggarwal': [1183, 1392], 'B.B.': [1184, 1393], 'Al-Ubaidi': [1185, 1394], 'M.R.': [1186, 1395], 'Agarwal': [1187, 1396], 'Biol.': [1190, 1284, 1399, 1562, 3604, 4350], 'Chem.': [1191, 1400, 1563, 3605, 4351], '274:': [1193, 1402, 4353], '3734-3743Abstract': [1194, 1403], 'Full': [1195, 1197, 1404, 1406, 1567, 3609, 3611, 3909, 4355, 4357], 'Text': [1196, 1198, 1405, 1407, 1568, 3610, 3612, 3910, 4356, 4358], 'PDF': [1199, 1408, 1569, 3613, 3911, 4359], '(138)': [1202, 1411], '20Glazner': [1205], 'G.W.': [1206], 'Camandola': [1207, 4276], '101-108Crossref': [1215], '(74)': [1218], 'developing': [1224], 'peripheral': [1225], '(21Maggirwar': [1227], 'S.B.': [1228], 'Sarmiere': [1229], 'P.D.': [1230], 'Dewhurst': [1231], 'Freeman': [1233], 'R.S.': [1234], '18:': [1238], '10356-10365Crossref': [1239], '22Hamanoue': [1243, 1414], 'Middleton': [1245, 1416], 'Wyatt': [1247, 1272, 1418], 'Jaffray': [1249, 1276, 1420], 'Hay': [1251, 1278, 1422], 'R.T.': [1252, 1279, 1423], 'Davies': [1253, 1280, 1424], 'Cell.': [1256, 1427, 3652], '28-40Crossref': [1260, 1431], '(174)': [1263, 1434], '23Middleton': [1266], 'Hamanoue': [1268], 'Enokido': [1270], 'Pennica': [1274], 'Cell': [1283, 1531, 2501], '148:': [1286], '325-332Crossref': [1287], '(126)': [1290], 'Furthermore,': [1293, 3515, 3749], 'inhibition': [1294, 3173], 'overexpression': [1298], 'treatment': [1302, 3088, 3114], 'inhibitors': [1305, 2207, 4029, 4222], 'Scholar,15Kaltschmidt': [1335], '16Choi': [1360], '24Pasquini': [1437], 'L.A.': [1438], 'Marta': [1439], 'C.B.': [1440], 'Adamo': [1441], 'Pasquini': [1443], 'J.M.': [1444, 3894], 'Soto': [1445], 'E.F.': [1446], '25:': [1450], '627-635Crossref': [1451], '(18)': [1454], 'important': [1464, 4252], 'death.': [1470], 'In': [1471, 3369, 3529], 'this': [1472, 1540, 3103, 3931], 'study,': [1473], 'examined': [1476], 'potential': [1478], '11-7082': [1489, 4103, 4159], 'andN-acetyl-Leu-Leu-norleucinal': [1490], '(ALLN)': [1491], 'obtained': [1493, 1500, 4169], 'Calbiochem.': [1495], 'All': [1496], 'reagents': [1498], 'Life': [1502], 'Technologies.': [1503], 'Polyclonal': [1504], 'antibodies': [1505, 2288, 3271, 3371], '(RelA),': [1508], 'RelB,': [1509, 3373], 'c-Rel,': [1510], 'p50,': [1511], 'p52,': [1512], 'IκBβ': [1515, 2341, 3512], 'purchased': [1517], 'Santa': [1519, 1522], 'Cruz': [1520, 1523], 'Biotechnology,': [1521], 'CA.': [1524], 'An': [1525, 1613], 'antibody': [1526, 2007, 2093, 2122, 3311, 3334, 3353, 3722], 'phospho-IκBα': [1528, 2354], 'Signaling': [1532], 'Technology,': [1533], 'Beverly': [1534], 'MA.': [1535], 'used': [1538, 1701, 2026, 2580, 2857, 3706, 3929], 'study': [1541], 'prepared': [1543, 1718, 1879, 3198, 3264], 'previously': [1545, 1729, 2978], 'described': [1546, 1730, 3227], '(25Becerra': [1547], 'Palmer': [1549], 'I.': [1550], 'Kumar': [1551], 'Steele': [1553], 'F.': [1554], 'Shiloach': [1555], 'Notario': [1557], 'V.': [1558], '1993;': [1564, 3832], '268:': [1565], '23148-23156Abstract': [1566], 'Briefly,': [1573, 2388, 2518], 'truncated': [1575], 'recombinant': [1576], 'construct': [1578], '(Asp-44–Pro-418)': [1579], 'cDNA': [1584, 2727, 2731, 2739], 'expressed': [1586], 'inEscherichia': [1587], 'coli,': [1588], 'purified': [1589], 'bacterial': [1592], 'inclusion': [1593], 'bodies,': [1594], 'stored,': [1595], 'urea': [1599, 1617, 1629], 'buffer': [1600, 1618, 2076, 2170, 2243, 2408], '(50': [1601], 'mm': [1602, 1608, 1772, 1775, 1957, 1961, 1964, 2173, 2184, 2187, 2190, 2193, 2196, 2212, 2763, 3808, 3815, 4048], 'sodium': [1603, 2082, 2414], 'phosphate,': [1604], 'pH': [1605, 2175, 2271], '6.5,': [1606], '150': [1607], 'NaCl,': [1609, 2179], '4': [1610, 2017, 2129, 2312, 3191], 'm': [1611, 2178], 'urea).': [1612], 'equivalent': [1614], 'volume': [1615, 2752], 'control/untreated': [1623], 'samples.': [1624], 'extract': [1630, 1925], 'coli': [1633], 'transfected': [1635], 'had': [1640, 4223], 'no': [1641, 3728, 4224], '26Sugita': [1661], '710-718Crossref': [1674], '(63)': [1677], 'Analysis': [1680], 'content': [1684], 'endotoxin': [1687, 1693], 'lipopolysaccharide': [1688], 'demonstrated': [1689], 'undetectable': [1690], '(<0.05': [1692], 'units/ml': [1694], 'at': [1695, 1796, 1802, 1815, 2016, 2123, 2128, 2227, 2311, 2333, 2398, 2430, 2688, 2698, 2816, 2823, 2831, 2973, 3048, 3057, 3108, 3246, 4150], 'lowest': [1697], 'dilution': [1698, 2125, 2335], 'assays)': [1703], 'using': [1704, 1749, 1955, 1975, 2145, 2373, 2453, 2513, 2728, 2850, 2961, 3042, 3314, 3493], 'Limulus': [1706], 'amebocyte': [1707], 'lysate': [1708, 2222], 'method': [1709], '(Associates': [1710], 'Cape': [1712], 'Cod,': [1713], 'Falmouth,': [1714], 'MA).': [1715], '8-day-old': [1720], 'Sprague-Dawley': [1721], 'rat': [1722], 'pups': [1723], '(Charles': [1724], 'River,': [1725], 'Wilmington,': [1726], 'MA)': [1727], 'protocol': [1751, 1883, 2363], 'approved': [1752], 'NINDS/NIH': [1755], 'Animal': [1756], 'Care': [1757], 'Use': [1759], 'Committee.': [1760], 'Cells': [1761, 2070], 'plated': [1763], 'serum-containing': [1765], "(Eagle's": [1767], 'basal': [1768, 3726], '25': [1771, 1956, 1960, 2545, 2754, 3807], 'KCl,': [1773], '2': [1774, 2004, 2085, 2112, 2285, 2417, 2528, 3084, 3259, 3420, 3736], 'glutamine,': [1776], '100': [1777, 2613, 2658, 2670, 4176], 'μg/ml': [1778, 2542], 'gentamycin,': [1779], '10%': [1781, 2250], 'heat-inactivated': [1782], 'bovine': [1784, 2104], 'serum)': [1785], 'poly-l-lysine-coated': [1787], '10-cm': [1788], 'dishes,': [1789], '8-well': [1790], 'chamber': [1791], 'slides,': [1792], '96-well': [1794, 2516, 2667], 'plates': [1795], '3.5': [1797], '×': [1798], '105': [1799], 'cells/cm2and': [1800], 'grown': [1801], '37': [1803, 2431], '°C': [1804, 2018, 2130, 2432, 2818, 2825, 2833], 'humidified': [1807], 'atmosphere.': [1808], 'Cytosine': [1809], 'arabinoside': [1810], 'DIV1': [1814], 'final': [1817, 2751], 'concentration': [1818, 2977, 3127], '10': [1820, 2189, 2192, 2195, 3572, 3621], 'μm.': [1821], 'On': [1822], 'DIV7,': [1823], 'cultures': [1828], 'consisted': [1829, 2756, 2812], '>98%': [1831], '(stained': [1833, 1841, 1851], 'anti-neuron': [1835], 'specific': [1836, 2770, 2867, 3172], 'enolase': [1837], 'antibody),': [1838, 1847], '<1%': [1839, 1849], 'astrocytes': [1840], 'anti-glial': [1843], 'fibrillary': [1844], 'acidic': [1845], 'protein': [1846, 3237, 3513, 3520], 'microglia': [1850], 'anti-OX42': [1853], 'antibody)': [1854], 'Nuclear': [1873, 3261], 'extracts': [1874, 3044, 3166, 3196, 3262, 3316], 'EMSAs': [1877, 2028], 'mini-extraction': [1882], '(27Schreiber': [1884], 'Matthias': [1886], 'P.': [1887, 3824, 3869, 3904], 'Muller': [1888], 'Schaffner': [1890], 'Nucleic': [1892, 3784], 'Acids': [1893, 3785], '1989;': [1895], '17:': [1896], '6419Crossref': [1897], '(3918)': [1900], 'EMSA': [1903, 2962], 'performed': [1905, 1985, 3310], 'commercial': [1908], 'kit': [1909, 2348, 2379, 2511, 2586, 2733], '(Promega': [1910], 'Corp.,': [1911], 'Madison,': [1912], 'WI)': [1913], 'according': [1914, 2380, 2707, 2781], "manufacturer's": [1917, 2383, 2784], 'instructions.': [1918, 2785], 'Two': [1919, 2717, 3036], '5': [1921, 2447, 3814, 4047, 4197], 'μg': [1922, 2718], 'nuclear': [1924, 2011, 3043, 3165, 3195, 3315, 3392, 3585, 3709, 3729], 'incubated': [1927, 2073, 2097, 2117, 2319, 2405, 2425, 2522, 2629, 2682, 3266], 'a32P-labeled': [1929], 'DNA': [1930, 2449, 2777, 2958], 'sequence': [1931, 3180], 'containing': [1932, 2102, 2171, 2279, 2303, 3217, 3804, 3813, 4046], 'AP-1,': [1934, 2040, 3148, 3220], 'CRE,': [1935, 3149, 3221], 'site.': [1939], 'DNA-protein': [1941, 1998, 3175, 3203, 3291], 'complexes': [1942, 3394, 3463], 'separated': [1944], 'unbound': [1946], 'oligonucleotide': [1947, 1995, 2024], 'native': [1951], '6%': [1952, 2280], 'polyacrylamide': [1953, 2251], 'gels': [1954, 1970], 'Tris': [1958], 'base,': [1959], 'borate,': [1962], '0.5': [1963, 2177, 2767], 'EDTA': [1965], 'buffer.': [1966], 'After': [1967, 2049, 2214, 2314, 2436], 'electrophoresis,': [1968], 'dried': [1972, 2282], 'analyzed': [1974, 2960, 3483], 'PhosphorImager': [1977], '(Molecular': [1978], 'Dynamics,': [1979], 'Sunnyvale,': [1980], 'CA).': [1981], 'Competition': [1982], 'experiments': [1983], 'co-incubation': [1987], '100-fold': [1990, 3140], 'excess': [1991, 3141], 'unlabeled': [1993, 3143, 3212], 'double-stranded': [1994], 'reaction.': [2000, 2022], 'For': [2001, 2590, 2654, 2926], 'supershift': [2002, 3312], 'analysis,': [2003, 2928], 'μl': [2005, 2204, 2614, 2659, 2671], 'preincubated': [2009], 'proteins': [2012, 3449, 3489], '30': [2014, 2068, 2631, 2686, 2814, 2821, 4106], 'min': [2015, 2086, 2218, 2418, 2687, 4107], 'Double-stranded': [2023], 'probes': [2025], 'follows': [2031], '(only': [2032], 'sense': [2034], 'strand': [2035, 2726], 'indicated):': [2037], '5′-AGTTGAGGGGACTTTCCCAGGC-3′;': [2039], '5′-CGCTTGATGAGTCAGCCGGAA-3′;': [2041], 'CREB': [2042], '(cAMP-response': [2043], 'element-binding': [2044], 'protein),': [2045], '5′-AGAGATTGCCTGACGTCAGAGAGCTAG-3′;': [2046], 'OCT-1,': [2047], '5′-TGTCGAATGCAAATCACTAGAA-3′.': [2048], 'experimental': [2050], 'treatments,': [2051], 'washed': [2054], '3': [2055, 3501, 3527, 3548, 3666], 'times': [2056], 'phosphate-buffered': [2058], 'fixed': [2061, 2391, 3718], 'incubating': [2063], '4%': [2065, 2393], 'paraformaldehyde': [2066, 2394], 'min.': [2069, 2232, 2448, 2632], 'then': [2072, 2255, 2402, 2424, 2620, 3283], 'permeabilization': [2075, 2407], '(0.1%': [2077, 2409], 'Triton': [2078, 2109, 2181, 2410, 2617], 'X-100': [2079, 2110, 2411, 2618], '0.1%': [2081, 2275, 2413], 'citrate)': [2083, 2415], 'ice.': [2088, 2420], 'To': [2089, 2572, 2608, 2943, 3298, 3469, 3550, 3697], 'block': [2090], 'nonspecific': [2092], 'binding,': [2094], 'blocking': [2100], 'solution': [2101], '1%': [2103, 2616], 'serum': [2105, 3805], 'albumin': [2106], '0.3%': [2108], 'h.': [2113, 2286, 2435, 3260], 'Next,': [2114], 'rabbit': [2119], 'polyclonal': [2120], 'anti-p65': [2121], '1:200': [2127], 'overnight': [2131, 2310], 'fluorescein': [2134], 'isothiocyanate-conjugated': [2135], 'goat': [2136], 'anti-rabbit': [2137, 2326], 'IgG': [2138, 2327, 2332], 'secondary': [2139], 'antibody.': [2140, 3748], 'images': [2142], 'acquired': [2144], 'confocal': [2147, 2456], 'laser-scanning': [2148], 'microscope': [2149], '100×': [2152], 'objective': [2153], '(488-nm': [2154], 'excitation': [2155], '510-nm': [2157], 'emission).': [2158], 'scraped': [2162], 'resuspended': [2164], '0.75': [2166], 'ml': [2167], 'lysis': [2169], 'Tris-HCl,': [2174], '7.4,': [2176], '0.25%': [2180], 'X-100,': [2182], '1': [2183, 2186, 2201, 2211, 2321, 2396, 2434, 3073, 3090, 3116, 3134, 3268, 4180], 'EDTA,': [2185], 'EGTA,': [2188], 'β-glycerophosphate,': [2191], 'NaF,': [2194], '4-nitrophenylphosphate,': [2197], '300': [2198], 'μm': [2199, 2546, 2768, 3573, 3622, 4177], 'Na3VO4,': [2200], 'mmbenzamidine,': [2202], '75': [2203], 'mixture': [2208], '(Sigma),': [2209], 'dithiothreitol.': [2213], 'incubation': [2215, 2267], 'ice,': [2220], 'cleared': [2224], 'centrifugation': [2226], '15,000': [2228], 'rpm': [2229], '15': [2231], 'Protein': [2233], '(10': [2234, 4099, 4104], 'μg)': [2235], 'lysates': [2238, 3536], 'boiled': [2240], 'Laemmli': [2242], 'electrophoresed': [2245], 'under': [2246, 3228, 3926], 'reducing': [2247], 'conditions': [2248, 3928], 'gels.': [2252], 'Proteins': [2253], 'transferred': [2256, 2664], 'polyvinylidene': [2259], 'difluoride': [2260], 'membrane.': [2261, 2571], 'Nonspecific': [2262], 'inhibited': [2265, 3674], 'mmTris,': [2270], '7.4-buffered': [2272], '(TBST)': [2278], 'nonfat': [2281], 'milk': [2283, 2305], 'Primary': [2287], 'IκBβ,': [2291], 'phospho-IκBα,': [2292], 'diluted': [2296], '1:1000,': [2297, 2298], '1:2000,and': [2299], '1:1000': [2300], 'TBST': [2302], '5%': [2304], 'exposed': [2307, 3442, 4174], 'membranes': [2309], '°C.': [2313], 'washing,': [2315], 'blots': [2317], 'horseradish': [2324, 2329], 'peroxidase-conjugated': [2325, 2330], 'anti-mouse': [2331], '1:10,000.': [2337], 'Immunoreactive': [2338], 'IκBα': [2339, 3510, 3519, 3764], 'diaminobenzidine': [2346], 'staining': [2347, 3730], '(Vector': [2349], 'Laboratories,': [2350], 'Burlingame,': [2351], 'CA),': [2352], 'enhanced': [2361], 'chemiluminescent': [2362], '(Amersham': [2364, 2734], 'Pharmacia': [2365, 2735], 'Biotech).': [2366, 2736], 'Apoptosis': [2367], 'TUNEL': [2371, 2427], 'thein': [2374], 'situ': [2375], 'detection': [2378, 2585], 'instructions': [2384, 2711], '(Roche': [2385, 2587], 'Molecular': [2386, 2588], 'Biochemicals).': [2387, 2589], 'room': [2399, 2689], 'temperature,': [2400, 2690], 'incubation,': [2437], 'stained': [2440, 2840, 3720], 'propidium': [2442], 'iodide': [2443], '(5': [2444], 'μg/ml)': [2445], 'fragmentation': [2450], 'evaluated': [2452], 'laser': [2455], 'microscope.': [2457], 'TUNEL-positive': [2458, 2481, 2489, 4055], 'counted': [2461], '2–6': [2463], 'randomly': [2464], 'selected': [2465], 'fields': [2466], 'two': [2468], 'different': [2469], 'chambers.': [2470], '600–1200': [2471], 'scored': [2474], 'each': [2476, 2661, 2679, 2769], 'treatment.': [2477], 'percentage': [2479, 2634], 'calculated': [2484, 2639], 'divided': [2491, 2646], 'total': [2494, 2610, 2648, 2720], '(propidium': [2498], 'iodide-stained': [2499], 'cells).': [2500], 'measured': [2504, 2697], 'MTS': [2507, 2531, 2543, 4187], 'proliferation': [2509], '(Promega)': [2512], 'plates.': [2517], 'CO2': [2525], 'incubator': [2526], '(3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-': [2532], 'tetrazolium,': [2533], 'salt)': [2535], 'phenazine': [2537, 2547], 'methosulfate': [2538], '(final': [2539], 'concentrations,': [2540], '333': [2541], 'methosulfate).': [2548], 'LDH,': [2549, 2594], 'stable': [2551], 'cytoplasmic': [2552], 'enzyme': [2553], 'present': [2554], 'rapidly': [2559], 'released': [2560, 2576, 2593], 'into': [2561], 'after': [2566, 2844, 2985, 3086, 3112, 3193, 3738], 'damage': [2567], 'plasma': [2570], 'measure': [2573], 'LDH': [2574, 2611, 2636, 2641, 2649, 2673, 4193], 'commercially': [2582], 'available': [2583], 'cytotoxicity': [2584], 'measurement': [2591], 'collected': [2598], 'centrifuged': [2600], 'remove': [2602], 'contaminating': [2603], 'cellular': [2606], 'debris.': [2607], 'activity,': [2612, 2951], 'wells,': [2624], 'release': [2637, 4194], '(cellular': [2650], 'plus': [2651], 'LDH).': [2653], 'actual': [2656, 2864], 'assay,': [2657], 'sample': [2662], 'microtiter': [2668], 'plate,': [2669], 'reagent': [2675], 'well': [2680], 'up': [2684], 'absorbance': [2693], 'samples': [2695], '490': [2699], 'nm.': [2700], 'Total': [2701], 'RNA': [2702, 2721], 'extracted': [2704], "manufacture's": [2710], 'TRIZOL': [2713], 'Reagent': [2714], '(Life': [2715, 2779], 'Technologies).': [2716], 'converted': [2723], 'first-strand': [2730], 'synthesis': [2732], 'resulting': [2738], 'subjected': [2741], 'PCR': [2743, 2746, 2837], 'analysis.': [2744, 3496], 'amplification': [2747, 2793], 'mixture,': [2748], 'μl,': [2755], '1×': [2758], 'TaqDNA': [2759], 'buffer,': [2761], '0.2': [2762], 'dNTPs,': [2764], '1.5': [2765], 'mmMgCl2,': [2766], 'primer,': [2771], '2.5': [2773], 'units': [2774], 'Taq': [2776], 'Technologies)': [2780], 'cycle': [2787, 2811], 'chosen': [2790], 'such': [2791], 'products': [2796, 2838], 'linear': [2800], 'respect': [2803], 'amount': [2806, 3359], 'input': [2808], 'cDNA.': [2809], 'Each': [2810], 's': [2815, 2822, 2830], '94': [2817], 'denaturation,': [2820], '60': [2824, 2829], 'annealing,': [2827], '72': [2832], 'extension.': [2835], 'ethidium': [2842], 'bromide': [2843], 'agarose': [2845], 'gel': [2846], 'photographed': [2849], 'Polaroid': [2851], 'film': [2852], 'type': [2853], '667.': [2854], 'Cyclophilin': [2855], 'non-changing': [2860], 'control': [2861], 'RNA.': [2862], 'sequences': [2865, 3225], 'primers': [2868], 'follows:': [2871], '(NGF)': [2875], 'sense,': [2876, 2885, 2895, 2901, 2906, 2914, 2921], '5′-CCAAGGGAGCAGCTTTCTATCCTGG-3′,': [2877], 'antisense': [2879], '5′-GGCAGTGTCAAGGGAATGCTGAAGT-3′;': [2880], '(BDNF)': [2884], '5′-AGCCTCCTCTGCTCTTTCTGCTGGA-3′,': [2886], 'antisense,': [2888, 2898, 2903, 2909, 2917, 2924], '5′-CTTTTGTCTATGCCCCTGCAGCCTT-3′;': [2889], '(GDNF)': [2894], '5′-ATGAAGTTATGGGATGTCGTGGCTG-3′,': [2896], '5′-CTAAGAAAGCATTCCGCTAAACGGT-3′;': [2899], '5′-CTCGTCGCTACCGTCGTGACTTCG-3′,': [2902], '5′-CAGATGCCGGTTCAGGTACTCAGTC-3′;': [2904], 'Bcl-x': [2905], '5′-AGGCTGGCGATGAGTTTGAACTGCG-3′,': [2907], '5′-GGCTCTAGGTGGTCATTCAGGTAGG-3′;': [2910], 'Mn-superoxide': [2911], '(SOD)': [2913], '5′-GACCTGCCTTACGACTATGG-3′,': [2915], '5′-GACCTTGCTCCTTATTGAAGC-3′;': [2918], 'cyclophilin': [2920], '5′-TGGACCAAACACAAATGGTT-3′,': [2922], '5′-TGATCTTCTTGCTGGTCTT-3′.': [2925], 'statistical': [2927], 'data': [2929], 'compared': [2931], '1-way': [2933], 'variance': [2936], "Fisher's": [2938], 'protected': [2939], 'least': [2940, 3109], 'square': [2941], 'difference.': [2942], 'determine': [2944, 4004], 'whether': [2945, 3471, 4005], 'affects': [2947], 'transcriptional': [2949], 'level': [2953, 3486], 'treated': [2965, 3185, 3242, 3253, 3570], 'without': [2968, 3364], '7': [2974, 4082], 'nm,': [2975], 'reported': [2979, 4120], 'prevent': [2981], 'exposure': [2986], 'K+/serum-free': [2989], 'bands': [3039, 3052, 3347], 'derived': [3045], 'DIV2,': [3049], 'whereas': [3050, 3352, 4220], 'three': [3051], 'DIV8': [3058, 3250, 4151, 4171], '(Fig.1,': [3059], 'A': [3060, 3092, 4064, 4115], 'B).': [3062, 3117, 3421, 3528, 4066, 4117], 'Time': [3063], 'course': [3064], 'showed': [3066], 'within': [3072], '(DIV2),': [3078], 'maximal': [3081], 'effect': [3082, 4023, 4087, 4203, 4225], '(Fig.': [3089, 3115, 3133, 3419, 3526, 3547, 3766, 4113, 4196], 'A).': [3091], 'similar': [3093], 'rapid': [3094, 3516], 'induction': [3095, 3104], '(DIV8),': [3101], 'sustained': [3106], '6': [3110, 4056], 'Induction': [3118], 'over': [3125, 3543], '0.5–10': [3130], 'nm': [3131, 4083], 'C).': [3135, 3549], 'oligonucleotide,': [3145], 'OCT-1': [3151, 3223], 'oligonucleotides,': [3152], 'displaced': [3153], '(Fig.2': [3156, 3413], 'A).Figure': [3157], '2Characterization': [3158], 'A,': [3171, 3502], 'complex': [3176, 3204, 3305, 3363], 'formation': [3177, 3205], 'motif.': [3181], '(7': [3188, 3256], 'nm)': [3189, 3257], 'h,': [3192], 'assayed': [3200], 'absence': [3208], 'presence': [3210], 'oligonucleotides': [3213], '(100-fold': [3214], 'molar': [3215], 'excess)': [3216], 'consensus': [3224], '“Experimental': [3229], 'Procedures.”': [3230], 'B': [3231], 'C,': [3233, 3329], 'identification': [3234], 'NFκB-binding': [3236], 'nuclei': [3239, 3742], 'DIV2': [3247, 4039], '(B)': [3248], '(C)': [3251], 'indicated': [3274], 'NFκB/Rel': [3275], 'proteins.': [3276, 3438], 'Binding': [3277], 'probe': [3281], 'assessed': [3284], 'EMSA.': [3286], 'Thearrowheads': [3287], 'indicate': [3288], 'PEDF-induced': [3289, 3565, 3686, 4006, 4233], 'complexes.View': [3292], 'Large': [3293], 'Image': [3294], 'Figure': [3295], 'ViewerDownload': [3296], '(PPT)': [3297], 'elucidate': [3299], 'nature': [3301], 'activated': [3306], 'PEDF,': [3308], 'As': [3323, 3497, 3662, 4118], 'shown': [3324, 3498, 3663, 3771], 'Figs.': [3326], '2,B': [3327], 'p50': [3333], 'resulted': [3335], 'complete': [3339], 'loss': [3340], 'lower': [3344, 3367], 'upper': [3346, 3362], 'complex,': [3351], 'reduced': [3357], 'affecting': [3365], 'one.': [3368], 'contrast,': [3370, 3530], 'cRel,': [3374], 'p-52': [3376], 'did': [3377, 4143], 'cross-react': [3379], 'complex.': [3383], 'analyses': [3385], 'contain': [3391], 'NFκB·Rel': [3393], 'composed': [3395], 'predominantly': [3396], 'p50/p65': [3398], 'heterodimer': [3399, 3406], 'p50/p50': [3401], 'homodimer.': [3402], 'Interestingly,': [3403], 'p65/p50': [3405], 'markedly': [3408], 'C)': [3414], 'relative': [3415], 'normally': [3424], 'sequestered': [3425], 'cytoplasm': [3428], 'inhibitory': [3437], 'When': [3439, 4038], 'activators': [3444], 'these': [3447, 4014], 'undergo': [3450, 3796], 'sequential': [3451], 'phosphorylation,': [3452], 'ubiquitination': [3453], 'proteosomal': [3455], 'degradation,': [3456], 'thereby': [3457], 'allowing': [3458], 'dimeric': [3462], 'nucleus.': [3468], 'examine': [3470], 'requires': [3477, 3689], 'proteosomes,': [3481], 'Western': [3494], 'blot': [3495], 'Fig.': [3500, 3665], 'caused': [3504, 4069], 'decrease': [3507], 'levels.': [3514], 'whole': [3534], 'changed': [3542], '6-h': [3545], 'period': [3546], 'provide': [3551], 'further': [3552, 3698], 'evidence': [3553], 'proteosomes': [3561], 'involved': [3563, 4238], 'activation,': [3567], 'subsequently': [3582], '(28Pierce': [3589], 'J.W.': [3590], 'Schoenleber': [3591], 'Jesmok': [3593], 'Best': [3595], 'Moore': [3597], 'S.A.': [3598, 3632, 3902], 'Collins': [3599], 'Gerritsen': [3601], 'M.E.': [3602], '272:': [3607], '21096-21103Abstract': [3608], '(921)': [3616], 'ALLN,': [3625], 'interferes': [3627], 'proteolysis': [3630], '(29Milligan': [3631], 'Owens': [3633], 'M.W.': [3634], 'Grisham': [3635], 'M.B.': [3636], 'Arch.': [3637], 'Biochem.': [3638], 'Biophys.': [3639], '335:': [3641], '388-395Crossref': [3642], '(55)': [3645], '30Schow': [3648], 'Joly': [3650], 'Immunol.': [3653], '175:': [3655], '199-202Crossref': [3656], '(43)': [3659], 'D,': [3667], 'pretreatment': [3668], 'BAY-11-7082': [3671], 'ALLN': [3673, 4098, 4156], 'activate': [3680], 'NFκB.': [3681], 'proteosomes.': [3696], 'protein,': [3703], 'immunohistochemistry': [3704], '(Fig.3': [3711], 'E).': [3712], 'Untreated': [3713], 'p65.': [3724], 'Under': [3725], 'conditions,': [3727], 'observed.': [3734], 'However,': [3735, 4288], 'exposure,': [3740], 'labeled': [3744], 'RT-PCR': [3750], '6),': [3767], 'been': [3770], 'be': [3773], 'regulated': [3774], '(31Ito': [3777], 'C.Y.': [3778], 'Kazantsev': [3779], 'A.G.': [3780], 'Baldwin': [3781], 'Jr.,': [3782], 'A.S.': [3783], '1994;': [3787, 3852], '22:': [3788], '3787-3792Crossref': [3789], '(209)': [3792], 'they': [3799], 'switched': [3801, 4042], 'KCl': [3809, 3816], 'serum-free': [3811, 4044], "(32D'Mello": [3817], 'Galli': [3819], 'Ciotti': [3821], 'Calissano': [3823, 3868], '90:': [3833], '10989-10993Crossref': [3834], '(853)': [3837], '33Yan': [3840], 'G.M.': [3841], 'Ni': [3842], 'Weller': [3844], 'Wood': [3846], 'K.A.': [3847], 'Paul': [3848], 'S.M.': [3849], '656:': [3853], '43-51Crossref': [3854], '34Galli': [3860], 'Meucci': [3862], 'O.': [3863], 'Scorziello': [3864], 'Werge': [3866], 'T.M.': [3867], 'Schettini': [3870], '15:': [3875, 3907], '1172-1179Crossref': [3876], 'Although': [3880], 'can': [3883, 3946], 'cause': [3884], 'apoptotic': [3886, 4061], 'necrotic': [3888, 3942], '(35Ankarcrona': [3891], 'Dypbukt': [3893], 'Bonfoco': [3895], 'Zhivotovsky': [3897], 'Orrenius': [3899], 'Lipton': [3901], 'Nicotera': [3903], 'Neuron.': [3905], '961-973Abstract': [3908], '(1699)': [3914], 'depending': [3917], 'type,': [3921], 'found': [3924], 'paper': [3932], 'induce': [3934], 'glutamate-mediated': [3935], 'occurs': [3939], 'process.': [3943], 'protect': [3947, 4145], 'K+/serum': [3951], 'deprivation': [3952], 'it': [3999], 'interest': [4002], 'We': [4019], 'therefore': [4020], 'tested': [4021], 'toxicity.': [4037, 4249], 'K+,': [4049], '∼50%': [4050], 'later,': [4058], 'indicative': [4059], '(Fig.4,': [4063], 'Neuronal': [4067], 'potassium': [4072], 'completely': [4075, 4091, 4211], 'prevented': [4076], '20-h': [4079], 'preincubation': [4080], 'μm)': [4100, 4105], '4,': [4114], 'already': [4119], '(data': [4152], 'shown).': [4154], 'Neither': [4155], 'nor': [4157], 'affected': [4160], 'CGC': [4161], 'alone.': [4165, 4228], 'Similar': [4166], '(Fig.5).': [4182], 'Results': [4183], '(Fig.5': [4189], 'A)': [4190], 'B)': [4198], 'also': [4210], 'inhibitors,': [4219], 'directly': [4237], 'roles': [4253], 'regulating': [4255], 'various': [4259], 'nervous': [4264, 4303], 'system': [4265, 4269], 'immune': [4268], '(36Mattson': [4270], 'Culmsee': [4272], 'C.,': [4273], 'Yu,': [4274], '74:': [4281], '443-456Crossref': [4282], '(434)': [4285], 'little': [4289], 'known': [4291], 'about': [4292], 'NFκB-regulated': [4293], 'associated': [4297], 'system.': [4304], 'et': [4306, 4331], 'al.': [4307, 4332], 'Tamatani': [4330], '(37Tamatani': [4333], 'Che': [4335], 'Y.H.': [4336], 'Ogawa': [4339], 'Mizuno': [4345], '8531-8538Abstract': [4354], '(533)': [4362]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2067510196', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2022, 'cited_by_count': 1}, {'year': 2020, 'cited_by_count': 2}, {'year': 2019, 'cited_by_count': 5}, {'year': 2018, 'cited_by_count': 3}, {'year': 2017, 'cited_by_count': 5}, {'year': 2016, 'cited_by_count': 5}, {'year': 2015, 'cited_by_count': 6}, {'year': 2014, 'cited_by_count': 7}, {'year': 2013, 'cited_by_count': 5}, {'year': 2012, 'cited_by_count': 5}], 'updated_date': '2024-12-30T02:28:41.199101', 'created_date': '2016-06-24'}
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