Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2067294658', 'doi': 'https://doi.org/10.1016/j.clinthera.2013.06.010', 'title': 'Are Hepatic Impairment Studies Necessary for Therapeutic Proteins?', 'display_name': 'Are Hepatic Impairment Studies Necessary for Therapeutic Proteins?', 'publication_year': 2013, 'publication_date': '2013-07-25', 'ids': {'openalex': 'https://openalex.org/W2067294658', 'doi': 'https://doi.org/10.1016/j.clinthera.2013.06.010', 'mag': '2067294658', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/23891362'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1016/j.clinthera.2013.06.010', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S185879095', 'display_name': 'Clinical Therapeutics', 'issn_l': '0149-2918', 'issn': ['0149-2918', '1879-114X'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5061426227', 'display_name': 'Jun Yang', 'orcid': 'https://orcid.org/0000-0002-4233-3220'}, 'institutions': [{'id': 'https://openalex.org/I1320320070', 'display_name': 'United States Food and Drug Administration', 'ror': 'https://ror.org/034xvzb47', 'country_code': 'US', 'type': 'government', 'lineage': ['https://openalex.org/I1299022934', 'https://openalex.org/I1320320070']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Jun Yang', 'raw_affiliation_strings': ['Office of Clinical Pharmacology, Office of Translational Sciences, US Food and Drug Administration, Silver Spring, Maryland.'], 'affiliations': [{'raw_affiliation_string': 'Office of Clinical Pharmacology, Office of Translational Sciences, US Food and Drug Administration, Silver Spring, Maryland.', 'institution_ids': ['https://openalex.org/I1320320070']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5065397717', 'display_name': 'Stacy S. Shord', 'orcid': 'https://orcid.org/0009-0000-9497-1171'}, 'institutions': [{'id': 'https://openalex.org/I1320320070', 'display_name': 'United States Food and Drug Administration', 'ror': 'https://ror.org/034xvzb47', 'country_code': 'US', 'type': 'government', 'lineage': ['https://openalex.org/I1299022934', 'https://openalex.org/I1320320070']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Stacy Shord', 'raw_affiliation_strings': ['Office of Clinical Pharmacology, Office of Translational Sciences, US Food and Drug Administration, Silver Spring, Maryland.'], 'affiliations': [{'raw_affiliation_string': 'Office of Clinical Pharmacology, Office of Translational Sciences, US Food and Drug Administration, Silver Spring, Maryland.', 'institution_ids': ['https://openalex.org/I1320320070']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100675711', 'display_name': 'Hong Zhao', 'orcid': 'https://orcid.org/0000-0003-4616-3123'}, 'institutions': [{'id': 'https://openalex.org/I1320320070', 'display_name': 'United States Food and Drug Administration', 'ror': 'https://ror.org/034xvzb47', 'country_code': 'US', 'type': 'government', 'lineage': ['https://openalex.org/I1299022934', 'https://openalex.org/I1320320070']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Hong Zhao', 'raw_affiliation_strings': ['Office of Clinical Pharmacology, Office of Translational Sciences, US Food and Drug Administration, Silver Spring, Maryland.'], 'affiliations': [{'raw_affiliation_string': 'Office of Clinical Pharmacology, Office of Translational Sciences, US Food and Drug Administration, Silver Spring, Maryland.', 'institution_ids': ['https://openalex.org/I1320320070']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5008374867', 'display_name': 'Yuxin Men', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I1320320070', 'display_name': 'United States Food and Drug Administration', 'ror': 'https://ror.org/034xvzb47', 'country_code': 'US', 'type': 'government', 'lineage': ['https://openalex.org/I1299022934', 'https://openalex.org/I1320320070']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Yuxin Men', 'raw_affiliation_strings': ['Office of Clinical Pharmacology, Office of Translational Sciences, US Food and Drug Administration, Silver Spring, Maryland.'], 'affiliations': [{'raw_affiliation_string': 'Office of Clinical Pharmacology, Office of Translational Sciences, US Food and Drug Administration, Silver Spring, Maryland.', 'institution_ids': ['https://openalex.org/I1320320070']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5086301726', 'display_name': 'Atiqur Rahman', 'orcid': 'https://orcid.org/0000-0002-9001-5059'}, 'institutions': [{'id': 'https://openalex.org/I1320320070', 'display_name': 'United States Food and Drug Administration', 'ror': 'https://ror.org/034xvzb47', 'country_code': 'US', 'type': 'government', 'lineage': ['https://openalex.org/I1299022934', 'https://openalex.org/I1320320070']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Atiqur Rahman', 'raw_affiliation_strings': ['Office of Clinical Pharmacology, Office of Translational Sciences, US Food and Drug Administration, Silver Spring, Maryland.'], 'affiliations': [{'raw_affiliation_string': 'Office of Clinical Pharmacology, Office of Translational Sciences, US Food and Drug Administration, Silver Spring, Maryland.', 'institution_ids': ['https://openalex.org/I1320320070']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 4210, 'currency': 'USD', 'value_usd': 4210, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 1.608, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 13, 'citation_normalized_percentile': {'value': 0.821937, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 87, 'max': 88}, 'biblio': {'volume': '35', 'issue': '9', 'first_page': '1444', 'last_page': '1451'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T12547', 'display_name': 'Pharmaceutical studies and practices', 'score': 0.9975, 'subfield': {'id': 'https://openalex.org/subfields/2735', 'display_name': 'Pediatrics, Perinatology and Child Health'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T12547', 'display_name': 'Pharmaceutical studies and practices', 'score': 0.9975, 'subfield': {'id': 'https://openalex.org/subfields/2735', 'display_name': 'Pediatrics, Perinatology and Child Health'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11016', 'display_name': 'Monoclonal and Polyclonal Antibodies Research', 'score': 0.9968, 'subfield': {'id': 'https://openalex.org/subfields/2741', 'display_name': 'Radiology, Nuclear Medicine and Imaging'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T12255', 'display_name': 'Biosimilars and Bioanalytical Methods', 'score': 0.9964, 'subfield': {'id': 'https://openalex.org/subfields/2403', 'display_name': 'Immunology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [], 'concepts': [{'id': 'https://openalex.org/C112705442', 'wikidata': 'https://www.wikidata.org/wiki/Q323936', 'display_name': 'Pharmacokinetics', 'level': 2, 'score': 0.90793645}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.87466645}, {'id': 'https://openalex.org/C98274493', 'wikidata': 'https://www.wikidata.org/wiki/Q128406', 'display_name': 'Pharmacology', 'level': 1, 'score': 0.5301051}, {'id': 'https://openalex.org/C2908647359', 'wikidata': 'https://www.wikidata.org/wiki/Q2625603', 'display_name': 'Population', 'level': 2, 'score': 0.47864234}, {'id': 'https://openalex.org/C535046627', 'wikidata': 'https://www.wikidata.org/wiki/Q30612', 'display_name': 'Clinical trial', 'level': 2, 'score': 0.44937235}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.3691281}, {'id': 'https://openalex.org/C99454951', 'wikidata': 'https://www.wikidata.org/wiki/Q932068', 'display_name': 'Environmental health', 'level': 1, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D008107', 'descriptor_name': 'Liver Diseases', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D011506', 'descriptor_name': 'Proteins', 'qualifier_ui': 'Q000493', 'qualifier_name': 'pharmacokinetics', 'is_major_topic': True}, {'descriptor_ui': 'D000911', 'descriptor_name': 'Antibodies, Monoclonal', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000911', 'descriptor_name': 'Antibodies, Monoclonal', 'qualifier_ui': 'Q000493', 'qualifier_name': 'pharmacokinetics', 'is_major_topic': False}, {'descriptor_ui': 'D002986', 'descriptor_name': 'Clinical Trials as Topic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016207', 'descriptor_name': 'Cytokines', 'qualifier_ui': 'Q000493', 'qualifier_name': 'pharmacokinetics', 'is_major_topic': False}, {'descriptor_ui': 'D016207', 'descriptor_name': 'Cytokines', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D057487', 'descriptor_name': 'Enzyme Therapy', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004798', 'descriptor_name': 'Enzymes', 'qualifier_ui': 'Q000493', 'qualifier_name': 'pharmacokinetics', 'is_major_topic': False}, {'descriptor_ui': 'D004798', 'descriptor_name': 'Enzymes', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000922', 'descriptor_name': 'Immunotoxins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000922', 'descriptor_name': 'Immunotoxins', 'qualifier_ui': 'Q000493', 'qualifier_name': 'pharmacokinetics', 'is_major_topic': False}, {'descriptor_ui': 'D008107', 'descriptor_name': 'Liver Diseases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D058990', 'descriptor_name': 'Molecular Targeted Therapy', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011506', 'descriptor_name': 'Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D057127', 'descriptor_name': 'Single-Chain Antibodies', 'qualifier_ui': 'Q000493', 'qualifier_name': 'pharmacokinetics', 'is_major_topic': False}, {'descriptor_ui': 'D057127', 'descriptor_name': 'Single-Chain Antibodies', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014481', 'descriptor_name': 'United States', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014486', 'descriptor_name': 'United States Food and Drug Administration', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1016/j.clinthera.2013.06.010', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S185879095', 'display_name': 'Clinical Therapeutics', 'issn_l': '0149-2918', 'issn': ['0149-2918', '1879-114X'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/23891362', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 23, 'referenced_works': ['https://openalex.org/W1969942339', 'https://openalex.org/W1970875728', 'https://openalex.org/W2011042500', 'https://openalex.org/W2011055527', 'https://openalex.org/W2017264099', 'https://openalex.org/W2024985051', 'https://openalex.org/W2027894892', 'https://openalex.org/W2041871645', 'https://openalex.org/W2042916360', 'https://openalex.org/W2044160586', 'https://openalex.org/W2062756251', 'https://openalex.org/W2081021748', 'https://openalex.org/W2082177367', 'https://openalex.org/W2124050480', 'https://openalex.org/W2131082981', 'https://openalex.org/W2144895900', 'https://openalex.org/W2145533061', 'https://openalex.org/W2152734037', 'https://openalex.org/W2164634712', 'https://openalex.org/W2168860536', 'https://openalex.org/W2176100822', 'https://openalex.org/W2403688157', 'https://openalex.org/W342872802'], 'related_works': ['https://openalex.org/W4364376666', 'https://openalex.org/W2991030316', 'https://openalex.org/W2960553615', 'https://openalex.org/W2908757458', 'https://openalex.org/W2887865523', 'https://openalex.org/W2594910449', 'https://openalex.org/W2352350815', 'https://openalex.org/W2189230703', 'https://openalex.org/W2162491061', 'https://openalex.org/W1969203961'], 'abstract_inverted_index': None, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2067294658', 'counts_by_year': [{'year': 2024, 'cited_by_count': 2}, {'year': 2023, 'cited_by_count': 1}, {'year': 2021, 'cited_by_count': 2}, {'year': 2020, 'cited_by_count': 2}, {'year': 2019, 'cited_by_count': 1}, {'year': 2016, 'cited_by_count': 3}, {'year': 2015, 'cited_by_count': 2}], 'updated_date': '2025-01-11T23:52:04.775431', 'created_date': '2016-06-24'}