Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2066956489', 'doi': 'https://doi.org/10.1523/jneurosci.3911-09.2010', 'title': 'Nitric Oxide Induces Pathological Synapse Loss by a Protein Kinase G-, Rho Kinase-Dependent Mechanism Preceded by Myosin Light Chain Phosphorylation', 'display_name': 'Nitric Oxide Induces Pathological Synapse Loss by a Protein Kinase G-, Rho Kinase-Dependent Mechanism Preceded by Myosin Light Chain Phosphorylation', 'publication_year': 2010, 'publication_date': '2010-01-20', 'ids': {'openalex': 'https://openalex.org/W2066956489', 'doi': 'https://doi.org/10.1523/jneurosci.3911-09.2010', 'mag': '2066956489', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/20089906', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/6633085'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1523/jneurosci.3911-09.2010', 'pdf_url': 'https://www.jneurosci.org/content/jneuro/30/3/973.full.pdf', 'source': {'id': 'https://openalex.org/S5555990', 'display_name': 'Journal of Neuroscience', 'issn_l': '0270-6474', 'issn': ['0270-6474', '1529-2401'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319739', 'host_organization_name': 'Society for Neuroscience', 'host_organization_lineage': ['https://openalex.org/P4310319739'], 'host_organization_lineage_names': ['Society for Neuroscience'], 'type': 'journal'}, 'license': 'cc-by-nc-sa', 'license_id': 'https://openalex.org/licenses/cc-by-nc-sa', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'hybrid', 'oa_url': 'https://www.jneurosci.org/content/jneuro/30/3/973.full.pdf', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5023432864', 'display_name': 'Carmen R. Sunico', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I39147953', 'display_name': 'Universidad de Cádiz', 'ror': 'https://ror.org/04mxxkb11', 'country_code': 'ES', 'type': 'education', 'lineage': ['https://openalex.org/I39147953']}], 'countries': ['ES'], 'is_corresponding': False, 'raw_author_name': 'Carmen R Sunico', 'raw_affiliation_strings': ['Área de Fisiología, Facultad de Medicina, Universidad de Cádiz, 11003 Cádiz, Spain'], 'affiliations': [{'raw_affiliation_string': 'Área de Fisiología, Facultad de Medicina, Universidad de Cádiz, 11003 Cádiz, Spain', 'institution_ids': ['https://openalex.org/I39147953']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5089429404', 'display_name': 'David González‐Forero', 'orcid': 'https://orcid.org/0000-0001-5748-9546'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'David González-Forero', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5058522284', 'display_name': 'Germán Domínguez-Vías', 'orcid': 'https://orcid.org/0000-0002-9546-9148'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Germán Domínguez', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5015217389', 'display_name': 'José Manuel García‐Verdugo', 'orcid': 'https://orcid.org/0000-0001-9872-6499'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'José Manuel García-Verdugo', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5003989084', 'display_name': 'Bernardo Moreno‐López', 'orcid': 'https://orcid.org/0000-0003-2897-6227'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Bernardo Moreno-López', 'raw_affiliation_strings': [], 'affiliations': []}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 3.089, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 67, 'citation_normalized_percentile': {'value': 0.891984, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 96, 'max': 97}, 'biblio': {'volume': '30', 'issue': '3', 'first_page': '973', 'last_page': '984'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10077', 'display_name': 'Molecular Mechanisms of Synaptic Plasticity and Neurological Disorders', 'score': 0.9997, 'subfield': {'id': 'https://openalex.org/subfields/2804', 'display_name': 'Cellular and Molecular Neuroscience'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10077', 'display_name': 'Molecular Mechanisms of Synaptic Plasticity and Neurological Disorders', 'score': 0.9997, 'subfield': {'id': 'https://openalex.org/subfields/2804', 'display_name': 'Cellular and Molecular Neuroscience'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10155', 'display_name': 'Role of Nitric Oxide in Health and Disease', 'score': 0.9994, 'subfield': {'id': 'https://openalex.org/subfields/2737', 'display_name': 'Physiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10301', 'display_name': 'Mitochondrial Dynamics and Reactive Oxygen Species Regulation', 'score': 0.9981, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/soluble-guanylyl-cyclase', 'display_name': 'Soluble guanylyl cyclase', 'score': 0.5478007}, {'id': 'https://openalex.org/keywords/nitric-oxide', 'display_name': 'Nitric Oxide', 'score': 0.51398}, {'id': 'https://openalex.org/keywords/synaptic-plasticity', 'display_name': 'Synaptic Plasticity', 'score': 0.506388}], 'concepts': [{'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.6673353}, {'id': 'https://openalex.org/C127445978', 'wikidata': 'https://www.wikidata.org/wiki/Q187181', 'display_name': 'Synapse', 'level': 2, 'score': 0.6645341}, {'id': 'https://openalex.org/C8035138', 'wikidata': 'https://www.wikidata.org/wiki/Q6017854', 'display_name': 'Myosin light-chain kinase', 'level': 3, 'score': 0.55832064}, {'id': 'https://openalex.org/C2777093181', 'wikidata': 'https://www.wikidata.org/wiki/Q15331450', 'display_name': 'RHOA', 'level': 3, 'score': 0.5488638}, {'id': 'https://openalex.org/C2778827303', 'wikidata': 'https://www.wikidata.org/wiki/Q7558945', 'display_name': 'Soluble guanylyl cyclase', 'level': 4, 'score': 0.5478007}, {'id': 'https://openalex.org/C169760540', 'wikidata': 'https://www.wikidata.org/wiki/Q207011', 'display_name': 'Neuroscience', 'level': 1, 'score': 0.52936864}, {'id': 'https://openalex.org/C201800478', 'wikidata': 'https://www.wikidata.org/wiki/Q24721770', 'display_name': 'Rho-associated protein kinase', 'level': 3, 'score': 0.5272521}, {'id': 'https://openalex.org/C11960822', 'wikidata': 'https://www.wikidata.org/wiki/Q242736', 'display_name': 'Phosphorylation', 'level': 2, 'score': 0.5080154}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.47799152}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.43436968}, {'id': 'https://openalex.org/C519581460', 'wikidata': 'https://www.wikidata.org/wiki/Q207843', 'display_name': 'Nitric oxide', 'level': 2, 'score': 0.3853295}, {'id': 'https://openalex.org/C62478195', 'wikidata': 'https://www.wikidata.org/wiki/Q828130', 'display_name': 'Signal transduction', 'level': 2, 'score': 0.33707863}, {'id': 'https://openalex.org/C134018914', 'wikidata': 'https://www.wikidata.org/wiki/Q162606', 'display_name': 'Endocrinology', 'level': 1, 'score': 0.1783199}, {'id': 'https://openalex.org/C173803235', 'wikidata': 'https://www.wikidata.org/wiki/Q419566', 'display_name': 'Guanylate cyclase', 'level': 3, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D017869', 'descriptor_name': 'Cyclic GMP-Dependent Protein Kinases', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D009046', 'descriptor_name': 'Motor Neurons', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': True}, {'descriptor_ui': 'D018994', 'descriptor_name': 'Myosin Light Chains', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D052248', 'descriptor_name': 'Nitric Oxide Synthase Type I', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D013569', 'descriptor_name': 'Synapses', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': True}, {'descriptor_ui': 'D054460', 'descriptor_name': 'rho-Associated Kinases', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D000704', 'descriptor_name': 'Analysis of Variance', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000831', 'descriptor_name': 'Animals, Newborn', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001933', 'descriptor_name': 'Brain Stem', 'qualifier_ui': 'Q000166', 'qualifier_name': 'cytology', 'is_major_topic': False}, {'descriptor_ui': 'D001933', 'descriptor_name': 'Brain Stem', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017869', 'descriptor_name': 'Cyclic GMP-Dependent Protein Kinases', 'qualifier_ui': 'Q000037', 'qualifier_name': 'antagonists & inhibitors', 'is_major_topic': False}, {'descriptor_ui': 'D017869', 'descriptor_name': 'Cyclic GMP-Dependent Protein Kinases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004268', 'descriptor_name': 'DNA-Binding Proteins', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D004268', 'descriptor_name': 'DNA-Binding Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004791', 'descriptor_name': 'Enzyme Inhibitors', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D004791', 'descriptor_name': 'Enzyme Inhibitors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D049452', 'descriptor_name': 'Green Fluorescent Proteins', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D049452', 'descriptor_name': 'Green Fluorescent Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020437', 'descriptor_name': 'Hypoglossal Nerve Diseases', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D020437', 'descriptor_name': 'Hypoglossal Nerve Diseases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D066298', 'descriptor_name': 'In Vitro Techniques', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016253', 'descriptor_name': 'Microscopy, Immunoelectron', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016253', 'descriptor_name': 'Microscopy, Immunoelectron', 'qualifier_ui': 'Q000379', 'qualifier_name': 'methods', 'is_major_topic': False}, {'descriptor_ui': 'D009046', 'descriptor_name': 'Motor Neurons', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D009046', 'descriptor_name': 'Motor Neurons', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009046', 'descriptor_name': 'Motor Neurons', 'qualifier_ui': 'Q000648', 'qualifier_name': 'ultrastructure', 'is_major_topic': False}, {'descriptor_ui': 'D018994', 'descriptor_name': 'Myosin Light Chains', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009569', 'descriptor_name': 'Nitric Oxide', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009569', 'descriptor_name': 'Nitric Oxide', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D052248', 'descriptor_name': 'Nitric Oxide Synthase Type I', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D052248', 'descriptor_name': 'Nitric Oxide Synthase Type I', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D052248', 'descriptor_name': 'Nitric Oxide Synthase Type I', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D009687', 'descriptor_name': 'Nuclear Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009687', 'descriptor_name': 'Nuclear Proteins', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D018408', 'descriptor_name': 'Patch-Clamp Techniques', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010766', 'descriptor_name': 'Phosphorylation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010766', 'descriptor_name': 'Phosphorylation', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}, {'descriptor_ui': 'D010766', 'descriptor_name': 'Phosphorylation', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D017729', 'descriptor_name': 'Presynaptic Terminals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017729', 'descriptor_name': 'Presynaptic Terminals', 'qualifier_ui': 'Q000648', 'qualifier_name': 'ultrastructure', 'is_major_topic': False}, {'descriptor_ui': 'D017729', 'descriptor_name': 'Presynaptic Terminals', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D017729', 'descriptor_name': 'Presynaptic Terminals', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D051381', 'descriptor_name': 'Rats', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017208', 'descriptor_name': 'Rats, Wistar', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013569', 'descriptor_name': 'Synapses', 'qualifier_ui': 'Q000648', 'qualifier_name': 'ultrastructure', 'is_major_topic': False}, {'descriptor_ui': 'D013569', 'descriptor_name': 'Synapses', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D013569', 'descriptor_name': 'Synapses', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D055366', 'descriptor_name': 'Synaptic Potentials', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D055366', 'descriptor_name': 'Synaptic Potentials', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D055366', 'descriptor_name': 'Synaptic Potentials', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016708', 'descriptor_name': 'Synaptophysin', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D016708', 'descriptor_name': 'Synaptophysin', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014162', 'descriptor_name': 'Transfection', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D050599', 'descriptor_name': 'Vesicular Glutamate Transport Protein 2', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D050599', 'descriptor_name': 'Vesicular Glutamate Transport Protein 2', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D050495', 'descriptor_name': 'Vesicular Inhibitory Amino Acid Transport Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D050495', 'descriptor_name': 'Vesicular Inhibitory Amino Acid Transport Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D054460', 'descriptor_name': 'rho-Associated Kinases', 'qualifier_ui': 'Q000037', 'qualifier_name': 'antagonists & inhibitors', 'is_major_topic': False}, {'descriptor_ui': 'D054460', 'descriptor_name': 'rho-Associated Kinases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1523/jneurosci.3911-09.2010', 'pdf_url': 'https://www.jneurosci.org/content/jneuro/30/3/973.full.pdf', 'source': {'id': 'https://openalex.org/S5555990', 'display_name': 'Journal of Neuroscience', 'issn_l': '0270-6474', 'issn': ['0270-6474', '1529-2401'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319739', 'host_organization_name': 'Society for Neuroscience', 'host_organization_lineage': ['https://openalex.org/P4310319739'], 'host_organization_lineage_names': ['Society for Neuroscience'], 'type': 'journal'}, 'license': 'cc-by-nc-sa', 'license_id': 'https://openalex.org/licenses/cc-by-nc-sa', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc6633085', 'pdf_url': 'https://europepmc.org/articles/pmc6633085?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6633085', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/20089906', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1523/jneurosci.3911-09.2010', 'pdf_url': 'https://www.jneurosci.org/content/jneuro/30/3/973.full.pdf', 'source': {'id': 'https://openalex.org/S5555990', 'display_name': 'Journal of Neuroscience', 'issn_l': '0270-6474', 'issn': ['0270-6474', '1529-2401'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319739', 'host_organization_name': 'Society for Neuroscience', 'host_organization_lineage': ['https://openalex.org/P4310319739'], 'host_organization_lineage_names': ['Society for Neuroscience'], 'type': 'journal'}, 'license': 'cc-by-nc-sa', 'license_id': 'https://openalex.org/licenses/cc-by-nc-sa', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/3', 'score': 0.52, 'display_name': 'Good health and well-being'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 67, 'referenced_works': ['https://openalex.org/W101141618', 'https://openalex.org/W1528604981', 'https://openalex.org/W1556577415', 'https://openalex.org/W1567217875', 'https://openalex.org/W1582714141', 'https://openalex.org/W1618384257', 'https://openalex.org/W1844659411', 'https://openalex.org/W1892379295', 'https://openalex.org/W1960195874', 'https://openalex.org/W1963664066', 'https://openalex.org/W1963785149', 'https://openalex.org/W1970205640', 'https://openalex.org/W1973765221', 'https://openalex.org/W1980310343', 'https://openalex.org/W1980354936', 'https://openalex.org/W1985501773', 'https://openalex.org/W1986129914', 'https://openalex.org/W1988309987', 'https://openalex.org/W1991736396', 'https://openalex.org/W1992255165', 'https://openalex.org/W1994044284', 'https://openalex.org/W1995177559', 'https://openalex.org/W1995643895', 'https://openalex.org/W1999968276', 'https://openalex.org/W2018400352', 'https://openalex.org/W2019731805', 'https://openalex.org/W2020740091', 'https://openalex.org/W2021926559', 'https://openalex.org/W2023986336', 'https://openalex.org/W2024275247', 'https://openalex.org/W2024497434', 'https://openalex.org/W2024862570', 'https://openalex.org/W2032824516', 'https://openalex.org/W2034818574', 'https://openalex.org/W2035082060', 'https://openalex.org/W2038247692', 'https://openalex.org/W2047933089', 'https://openalex.org/W2050597447', 'https://openalex.org/W2055839901', 'https://openalex.org/W2061895982', 'https://openalex.org/W2068122311', 'https://openalex.org/W2069500544', 'https://openalex.org/W2070799367', 'https://openalex.org/W2074698065', 'https://openalex.org/W2078069653', 'https://openalex.org/W2081903103', 'https://openalex.org/W2083571984', 'https://openalex.org/W2085935168', 'https://openalex.org/W2088860578', 'https://openalex.org/W2091590679', 'https://openalex.org/W2095020146', 'https://openalex.org/W2096312363', 'https://openalex.org/W2104773372', 'https://openalex.org/W2105280248', 'https://openalex.org/W2112516420', 'https://openalex.org/W2112952507', 'https://openalex.org/W2115026925', 'https://openalex.org/W2123403836', 'https://openalex.org/W2127235616', 'https://openalex.org/W2137067026', 'https://openalex.org/W2144634097', 'https://openalex.org/W2148013477', 'https://openalex.org/W2150553711', 'https://openalex.org/W2154653383', 'https://openalex.org/W2167259420', 'https://openalex.org/W2169991415', 'https://openalex.org/W63195814'], 'related_works': ['https://openalex.org/W50052632', 'https://openalex.org/W3182155301', 'https://openalex.org/W3129288018', 'https://openalex.org/W2416701101', 'https://openalex.org/W2159532873', 'https://openalex.org/W2062199496', 'https://openalex.org/W204579434', 'https://openalex.org/W2020985989', 'https://openalex.org/W1988653710', 'https://openalex.org/W1750949018'], 'abstract_inverted_index': {'The': [0], 'molecular': [1, 143], 'signaling': [2], 'that': [3, 34, 141], 'underpins': [4], 'synapse': [5, 43, 92, 137, 147], 'loss': [6, 44, 148], 'in': [7, 22, 153], 'neuropathological': [8, 155], 'conditions': [9], 'remains': [10], 'unknown.': [11], 'Concomitant': [12], 'upregulation': [13], 'of': [14, 30, 64, 84, 133], 'the': [15, 28, 65, 131], 'neuronal': [16], 'nitric': [17], 'oxide': [18], '(NO)': [19], 'synthase': [20], '(nNOS)': [21], 'neurodegenerative': [23], 'processes': [24], 'places': [25], 'NO': [26, 90], 'at': [27, 47], 'center': [29], 'attention.': [31], 'We': [32, 139], 'found': [33], 'de': [35], 'novo': [36], 'nNOS': [37], 'expression': [38], 'was': [39, 111], 'sufficient': [40], 'to': [41, 101], 'induce': [42], 'from': [45, 56], 'motoneurons': [46], 'adult': [48], 'and': [49, 74, 105, 129], 'neonatal': [50, 57], 'stages.': [51], 'In': [52, 116], 'brainstem': [53], 'slices': [54], 'obtained': [55], 'animals,': [58], 'this': [59, 142], 'effect': [60], 'required': [61], 'prolonged': [62], 'activation': [63], 'soluble': [66], 'guanylyl': [67], 'cyclase': [68], '(sGC)/protein': [69], 'kinase': [70, 76], 'G': [71], '(PKG)': [72], 'pathway': [73], 'RhoA/Rho': [75], '(ROCK)': [77], 'signaling.': [78, 115], 'Synapse': [79], 'elimination': [80], 'involved': [81], 'paracrine/retrograde': [82], 'action': [83], 'NO.': [85], 'Furthermore,': [86], 'before': [87, 136], 'bouton': [88], 'detachment,': [89], 'increased': [91, 130], 'myosin': [93], 'light': [94], 'chain': [95], 'phosphorylation': [96, 110], '(p-MLC),': [97], 'which': [98], 'is': [99], 'known': [100], 'trigger': [102, 146], 'actomyosin': [103], 'contraction': [104], 'neurite': [106], 'retraction.': [107], 'NO-induced': [108], 'MLC': [109], 'dependent': [112], 'on': [113], 'cGMP/PKG-ROCK': [114], 'adulthood,': [117], 'motor': [118], 'nerve': [119], 'injury': [120], 'induced': [121], 'NO/cGMP-dependent': [122], 'synaptic': [123], 'stripping,': [124], 'strongly': [125], 'affecting': [126], 'ROCK-expressing': [127], 'synapses,': [128], 'percentage': [132], 'p-MLC-expressing': [134], 'inputs': [135], 'destabilization.': [138], 'propose': [140], 'cascade': [144], 'could': [145], 'underlying': [149], 'early': [150], 'cognitive/motor': [151], 'deficits': [152], 'several': [154], 'states.': [156]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2066956489', 'counts_by_year': [{'year': 2023, 'cited_by_count': 1}, {'year': 2022, 'cited_by_count': 2}, {'year': 2021, 'cited_by_count': 4}, {'year': 2020, 'cited_by_count': 7}, {'year': 2019, 'cited_by_count': 3}, {'year': 2018, 'cited_by_count': 1}, {'year': 2017, 'cited_by_count': 4}, {'year': 2016, 'cited_by_count': 2}, {'year': 2015, 'cited_by_count': 5}, {'year': 2014, 'cited_by_count': 13}, {'year': 2013, 'cited_by_count': 1}, {'year': 2012, 'cited_by_count': 6}], 'updated_date': '2024-09-18T18:16:40.139464', 'created_date': '2016-06-24'}