Dopamine D2-like Receptors Are Expressed in Pancreatic Beta Cells and Mediate Inhibition of Insulin Secretion

Name: Work Video:
Duration: 3 min 30 s
Blanca Rubı́; Sanda Ljubicic; Shirin Pournourmohammadi; Stefania Carobbio; Mathieu Armanet; Clarissa Bartley; Pierre Maechler
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'https://openalex.org/W2092431191', 'https://openalex.org/W2078633164', 'https://openalex.org/W2059434400', 'https://openalex.org/W2059002674', 'https://openalex.org/W2039482493', 'https://openalex.org/W20057113', 'https://openalex.org/W2003790404', 'https://openalex.org/W1969172543'], 'abstract_inverted_index': {'Dopamine': [0, 83, 190, 245, 328, 435, 490, 1206, 2593, 2733, 3020, 3121, 3319, 3378, 3506, 3540, 3610, 3651, 3950, 3967, 4123, 4139], 'signaling': [1, 246], 'is': [2, 123, 247, 368, 491, 654, 668, 3515, 3709, 3717, 3991], 'mediated': [3, 74, 248, 319], 'by': [4, 23, 52, 75, 125, 167, 228, 249, 268, 297, 320, 370, 412, 473, 657, 670, 786, 791, 798, 1134, 1143, 1248, 1274, 1377, 1397, 1441, 1695, 1877, 2072, 2550, 2575, 2772, 2802, 2863, 2884, 2924, 3159, 3260, 3306, 3385, 3433, 3486, 3532, 3561, 3678, 3729, 3802, 3836, 3945, 4096, 4147], 'five': [5, 250, 1831], 'cloned': [6, 251], 'receptors,': [7, 236, 252, 481, 1890, 2636], 'grouped': [8, 253], 'into': [9, 254], 'D1-like': [10, 255], '(D1': [11, 256], 'and': [12, 14, 18, 43, 62, 65, 86, 112, 118, 137, 143, 257, 259, 263, 288, 307, 310, 331, 357, 363, 382, 388, 501, 509, 605, 636, 667, 727, 800, 869, 1022, 1094, 1109, 1129, 1146, 1191, 1198, 1211, 1245, 1259, 1314, 1382, 1424, 1430, 1443, 1496, 1525, 1546, 1583, 1602, 1619, 1650, 1671, 1701, 1730, 1762, 1819, 1891, 1935, 1972, 1992, 2000, 2019, 2067, 2104, 2147, 2153, 2226, 2241, 2260, 2318, 2345, 2400, 2434, 2466, 2473, 2528, 2545, 2579, 2599, 2608, 2614, 2628, 2631, 2633, 2648, 2653, 2690, 2722, 2739, 2770, 2937, 2963, 2980, 2996, 3001, 3007, 3040, 3114, 3139, 3164, 3209, 3303, 3310, 3320, 3333, 3428, 3450, 3495, 3507, 3574, 3611, 3637, 3658, 3716, 3862, 3933, 4005, 4136], 'D5)': [13, 258], 'D2-like': [15, 88, 144, 202, 260, 333, 389, 447, 1016, 4150], '(D2,': [16, 261], 'D3': [17, 262, 2632], 'D4)': [19, 264], 'families.': [20, 265], 'We': [21, 69, 266, 314, 1121], 'identified': [22, 77, 267, 322], 'reverse': [24, 269, 1224, 1275, 1370, 2674, 4037], 'transcription-PCR': [25, 270], 'the': [26, 76, 87, 152, 178, 205, 225, 271, 321, 332, 397, 423, 450, 470, 651, 664, 692, 704, 764, 782, 862, 872, 978, 991, 995, 1004, 1015, 1123, 1130, 1135, 1249, 1262, 1367, 1518, 1570, 1575, 1684, 1688, 1760, 1763, 1767, 1780, 1843, 1951, 2006, 2009, 2165, 2173, 2221, 2261, 2266, 2322, 2371, 2377, 2388, 2401, 2406, 2446, 2519, 2522, 2534, 2542, 2564, 2603, 2657, 2667, 2707, 2714, 2720, 2725, 2728, 2744, 2750, 2793, 2816, 2826, 2829, 2841, 2851, 2856, 2860, 2864, 2875, 2880, 2901, 2915, 2941, 2973, 3049, 3053, 3067, 3124, 3149, 3169, 3184, 3187, 3272, 3329, 3434, 3523, 3550, 3620, 3698, 3710, 3720, 3753, 3769, 3775, 3850, 3958, 3999, 4020, 4031, 4053, 4058, 4107, 4153], 'presence': [27, 272, 996, 2520, 2604, 2745, 2902, 3054, 3188, 3699, 3754, 3851, 3959, 4000], 'of': [28, 60, 115, 133, 212, 273, 305, 360, 378, 457, 540, 607, 629, 694, 703, 864, 871, 910, 938, 997, 1007, 1014, 1068, 1125, 1205, 1251, 1264, 1271, 1299, 1326, 1334, 1353, 1369, 1477, 1522, 1699, 1711, 1723, 1726, 1733, 1785, 1791, 1888, 1900, 1950, 2008, 2016, 2058, 2223, 2239, 2326, 2370, 2445, 2521, 2536, 2592, 2605, 2656, 2666, 2706, 2727, 2732, 2746, 2815, 2836, 2845, 2859, 2879, 2896, 2903, 2914, 2935, 2943, 2958, 3019, 3055, 3058, 3069, 3137, 3151, 3162, 3189, 3291, 3318, 3331, 3351, 3436, 3448, 3505, 3525, 3549, 3650, 3686, 3692, 3700, 3705, 3712, 3755, 3852, 3881, 3906, 3938, 3960, 4001, 4019, 4030, 4109, 4115, 4149], 'dopamine': [29, 142, 155, 182, 229, 235, 274, 387, 400, 427, 474, 480, 541, 630, 816, 865, 911, 943, 987, 998, 1008, 2606, 2609, 2635, 2643, 2781, 2817, 2837, 2944, 3059, 3098, 3152, 3292, 3332, 3449, 3487, 3526, 3573, 3622, 3805, 3834, 3918, 3946, 3988, 4011, 4113, 4154], 'receptors': [30, 78, 183, 275, 323, 428, 999, 2607, 2748, 3166, 3302, 3305, 3962, 4007, 4124, 4151], 'from': [31, 276, 650, 822, 1115, 1148, 1188, 1242, 2556, 2719, 3348, 3667], 'both': [32, 277, 1523], 'families': [33, 278], 'in': [34, 41, 99, 170, 186, 209, 221, 230, 238, 279, 286, 344, 415, 431, 454, 466, 475, 483, 499, 542, 634, 642, 730, 763, 819, 861, 866, 982, 1000, 1057, 1064, 1176, 1200, 1208, 1366, 1379, 1387, 1399, 1404, 1492, 1501, 1641, 1652, 1687, 1708, 1759, 1833, 1895, 1908, 1943, 1998, 2061, 2111, 2125, 2135, 2161, 2265, 2299, 2313, 2331, 2357, 2395, 2405, 2454, 2504, 2518, 2595, 2611, 2672, 2700, 2736, 2753, 2822, 2886, 2921, 2951, 2961, 3024, 3045, 3048, 3052, 3073, 3077, 3168, 3178, 3183, 3242, 3322, 3338, 3455, 3467, 3536, 3569, 3576, 3592, 3603, 3661, 3697, 3735, 3743, 3752, 3765, 3787, 3797, 3839, 3849, 3879, 3947, 3952, 3963, 3975, 3980, 4013, 4071, 4119, 4127], 'INS-1E': [35, 61, 103, 171, 280, 306, 348, 416, 1020, 1209, 1243, 1478, 2112, 2162, 2300, 2354, 2501, 2612, 2621, 2737, 2762, 2805, 2887, 3025, 3046, 3078, 3537, 3604, 3662, 3736, 3766, 3840, 4128], 'insulin-secreting': [36, 281], 'cells': [37, 282, 868, 968, 1244, 1381, 1409, 1437, 1481, 1571, 1622, 1906, 1985, 2113, 2163, 2215, 2301, 2355, 2384, 2502, 2538, 2613, 2623, 2755, 2763, 2806, 2954, 2971, 3047, 3079, 3180, 3244, 3346, 3414, 3593, 3605, 3737, 3767, 3782, 3812, 3983, 4130], 'as': [38, 40, 160, 162, 283, 285, 405, 407, 505, 547, 699, 959, 1027, 1155, 1286, 2003, 2065, 2531, 2563, 2568, 2586, 2678, 2680, 2687, 2711, 2756, 2758, 2870, 3567, 3606, 3676, 3894, 4008, 4010, 4044, 4131, 4133], 'well': [39, 161, 284, 406, 1029, 2679, 2757, 4009, 4132], 'rodent': [42, 64, 287, 309, 1099, 3981], 'human': [44, 66, 119, 289, 311, 364, 1183, 1400, 1425, 3964, 4014, 4073, 4137], 'isolated': [45, 290, 907, 1142, 1193, 1429, 3347, 3352, 3456, 4072], 'islets.': [46, 291, 2965, 4138], 'D2': [47, 292, 1516, 1848, 1889, 2626, 2646, 2735, 2747, 2876, 2959, 2983, 3003, 3163, 3922, 3961, 4086], 'receptor': [48, 89, 293, 334, 1017, 1514, 1846, 2768, 2782, 2818, 2838, 2881, 2945, 2960, 2984, 3004, 3968, 3989, 4087, 4156], 'expression': [49, 294, 1375, 1395, 2222, 2369], 'was': [50, 295, 1132, 1215, 1266, 1285, 1659, 1673, 1693, 1706, 1757, 1770, 1875, 2070, 2109, 2130, 2258, 2263, 2403, 2439, 2548, 2584, 2661, 2676, 2807, 2848, 2882, 2919, 3029, 3296, 3558, 3800, 4025, 4065], 'confirmed': [51, 296, 2940], 'immunodetection': [53, 298], 'revealing': [54, 299], 'localization': [55, 300, 2814], 'on': [56, 79, 301, 324, 631, 637, 1412, 1421, 1597, 1638, 2792, 2850, 2899, 2933, 2968, 3021, 3095, 3142, 3153, 3293, 3335, 3509, 3527, 3546, 3652, 3993], 'insulin': [57, 96, 193, 213, 243, 302, 341, 438, 458, 488, 632, 734, 826, 873, 914, 939, 1557, 2017, 2021, 2025, 2068, 2998, 3102, 3132, 3154, 3175, 3240, 3258, 3294, 3336, 3363, 3383, 3402, 3419, 3465, 3519, 3579, 3972, 3994, 4094, 4117, 4142], 'secretory': [58, 303, 874, 2787, 2949, 3273, 3429, 3478, 3721], 'granules': [59, 304, 2788, 2950], 'primary': [63, 108, 308, 353, 1509, 2952, 2974], 'beta': [67, 80, 104, 110, 172, 188, 240, 312, 325, 349, 355, 417, 433, 485, 639, 652, 867, 967, 983, 1001, 1031, 1621, 2622, 2754, 2888, 2953, 2989, 2993, 3345, 3413, 3538, 3811, 3948, 3965, 3982, 4121, 4129], 'cells.': [68, 173, 189, 313, 418, 434, 1002, 2889, 2990, 2994, 3170, 3539, 3841, 3949, 3966, 4122], 'then': [70, 315, 1439, 1506, 1993, 2319], 'tested': [71, 98, 316, 343, 2529, 3030, 3127, 3147, 3454, 3522, 3830], 'potential': [72, 317, 2108, 2129, 2438], 'effects': [73, 318, 1006, 3330, 3447, 3524, 3545, 3643], 'cell': [81, 157, 326, 402, 548, 640, 653, 984, 1032, 1629, 1754, 1901, 3343, 3411, 3673, 3694, 3713], 'function.': [82, 327], '(10': [84, 329, 1645, 1740, 2050, 3268, 3379, 3397, 3541, 3623, 3891, 3919], 'μm)': [85, 93, 330, 338, 2394, 3255, 3269, 3380, 3398, 3542, 3566, 3624, 3640, 3920, 3926, 4091], 'agonist': [90, 335, 3191, 3211, 3266, 3395, 3923, 4088], 'quinpirole': [91, 336, 3192, 3253, 3334, 3396, 3439, 3451, 3496, 3562, 3612, 3638, 3924, 4089], '(5': [92, 337, 3254, 3639, 3925, 4090], 'inhibited': [94, 191, 339, 436, 3100, 3256, 3271, 3381, 3400, 3432, 3485, 4092, 4140], 'glucose-stimulated': [95, 192, 340, 437, 913, 3101, 3174, 3257, 3382, 3401, 3418, 3518, 4093, 4116, 4141], 'secretion': [97, 342, 609, 633, 784, 789, 827, 940, 3028, 3103, 3155, 3176, 3241, 3259, 3295, 3337, 3364, 3384, 3403, 3420, 3466, 4064, 4095, 4118], 'several': [100, 345], 'models,': [101, 346], 'i.e.': [102, 347], 'cells,': [105, 111, 241, 350, 356, 486, 1025], 'fluorescence-activated': [106, 351, 3342], 'cell-sorted': [107, 352], 'rat': [109, 354, 1246, 1383, 1881, 2024, 2615, 2638, 2865, 2938, 2962, 2988, 3353], 'pancreatic': [113, 187, 239, 358, 432, 484, 638, 3339, 4120], 'islets': [114, 359, 1140, 1172, 1192, 1247, 1427, 2049, 2616, 2639, 2934, 3340, 3354, 3458, 3469, 4015, 4074], 'rat,': [116, 361, 1422, 4134], 'mouse,': [117, 362, 1423, 4135], 'origin.': [120, 365], 'Insulin': [121, 366, 648, 788, 1904, 3022, 3144, 4063], 'exocytosis': [122, 367, 649, 735], 'controlled': [124, 369, 656], 'metabolism': [126, 371, 687, 793], 'coupled': [127, 372], 'to': [128, 201, 218, 373, 446, 463, 720, 780, 973, 986, 1012, 1337, 1574, 1667, 1766, 1772, 1797, 1869, 2376, 2509, 2663, 2809, 2855, 2892, 3275, 3278, 3417, 3480, 3564, 3669, 3723, 3774, 3815, 4027, 4057, 4076], 'cytosolic': [129, 163, 374, 408, 731, 1685, 2224, 3595, 3601, 3706, 3747, 3798], 'calcium': [130, 164, 375, 409, 721, 725, 2295, 2352], 'changes.': [131, 376], 'Measurements': [132, 377], 'glucose-induced': [134, 379, 3547, 3584, 3616, 3693, 3746, 3791], 'mitochondrial': [135, 380, 686, 2351, 3513, 3528, 3551, 3585, 3760, 3788, 3792], 'hyperpolarization': [136, 381, 3530, 3548], 'ATP': [138, 383, 2105, 2157, 3588, 3602, 3617, 3626], 'generation': [139, 384], 'showed': [140, 385, 2779], 'that': [141, 181, 197, 386, 426, 442, 494, 966, 1359, 2780, 3252, 3987], 'agonists': [145, 390], 'did': [146, 391, 3128, 3613], 'not': [147, 392, 3129, 3297, 3315, 3559, 3582, 3614], 'inhibit': [148, 393, 912, 3615], 'glucose': [149, 168, 231, 394, 413, 476, 661, 792, 830, 2514, 3044, 3084, 3238, 3358, 3375, 3392, 3482, 3535, 3631, 3666, 3732, 3780, 3816, 3865, 4079], 'metabolism.': [150, 395], 'On': [151, 396, 2840, 3619], 'other': [153, 398, 2904], 'hand,': [154, 399], 'decreased': [156, 401], 'membrane': [158, 403, 666, 706, 1755, 1902, 2107, 2128, 2437, 2795, 2831, 2917, 3529, 3552, 3674, 3695, 3714], 'depolarization': [159, 404, 702, 3696, 3715], 'increases': [165, 410], 'evoked': [166, 411, 790, 3728], 'stimulation': [169, 414, 3034], 'These': [174, 419], 'results': [175, 216, 420, 461, 860], 'show': [176, 421], 'for': [177, 422, 1217, 1261, 1283, 1294, 1304, 1311, 1316, 1374, 1394, 1416, 1432, 1489, 1498, 1588, 1625, 1661, 1675, 1745, 1783, 1809, 1859, 1886, 1898, 1937, 1995, 2014, 2119, 2231, 2243, 2303, 2343, 2348, 2360, 2397, 2464, 2515, 3359, 3517, 3719], 'first': [179, 424, 1633], 'time': [180, 425], 'are': [184, 429, 778, 1009, 2561, 2698, 3066], 'expressed': [185, 237, 430, 482, 2624, 2640, 2906, 3167], 'secretion,': [194, 439, 3520, 3580, 4143], 'an': [195, 440, 4144], 'effect': [196, 441, 3150, 3290, 4145], 'could': [198, 443, 3156], 'be': [199, 444, 795, 970, 2911, 3157], 'ascribed': [200, 445, 1011], 'receptors.': [203, 448], 'Regarding': [204, 449], 'molecular': [206, 451, 979, 4110], 'mechanisms': [207, 452, 980, 4111], 'implicated': [208, 453, 981], 'dopamine-mediated': [210, 455], 'inhibition': [211, 456, 606, 870, 3691, 3944, 4114], 'release,': [214, 459, 3473], 'our': [215, 460], 'point': [217, 462], 'distal': [219, 464], 'steps': [220, 465], 'metabolism-secretion': [222, 467, 658], 'coupling.': [223, 468, 659], 'Thus,': [224, 469], 'role': [226, 471, 498], 'played': [227, 472], 'homeostasis': [232, 477], 'might': [233, 478, 969], 'involve': [234, 479], 'modulating': [242, 487], 'release.': [244, 489], 'a': [492, 496, 700, 728, 855, 960, 1028, 1058, 1065, 1388, 1405, 1493, 1607, 1653, 1696, 1718, 2056, 2136, 2332, 2455, 2551, 2580, 2843, 3032, 3279, 3784, 3832, 3845, 3895], 'neurotransmitter': [493], 'plays': [495], 'critical': [497], 'neurological': [500], 'psychiatric': [502], 'disorders,': [503], 'such': [504, 546, 3831], 'schizophrenia,': [506], 'Parkinson': [507, 823], 'disease,': [508], 'drug': [510], 'addiction': [511], '(1Callier': [512], 'S.': [513, 518, 583, 595, 1037, 1159, 1914, 2030, 2274, 2413, 2480, 3224], 'Snapyan': [514], 'M.': [515, 836, 3214], 'Le': [516], 'Crom': [517], 'Prou': [519], 'D.': [520], 'Vincent': [521], 'J.D.': [522], 'Vernier': [523], 'P.': [524, 553, 708, 737, 1045, 1161, 1459, 1922, 2038, 2084, 2178, 2196, 2282, 2421, 2488], 'Biol.': [525, 1461, 2086, 2205], 'Cell.': [526], '2003;': [527, 2206], '95:': [528], '489-502Crossref': [529], 'PubMed': [530, 569, 600, 623, 680, 713, 742, 755, 773, 809, 848, 886, 901, 928, 953, 1050, 1166, 1471, 1927, 2043, 2096, 2188, 2209, 2287, 2426, 2493, 3229, 3823], 'Scopus': [531, 570, 601, 624, 681, 714, 743, 756, 774, 810, 849, 887, 902, 929, 954, 1051, 1167, 1472, 1928, 2044, 2097, 2189, 2210, 2288, 2427, 2494, 3205, 3230, 3824], '(155)': [532], 'Google': [533, 572, 603, 626, 683, 716, 745, 758, 776, 812, 851, 889, 904, 931, 956, 1053, 1169, 1474, 1543, 1930, 2046, 2099, 2191, 2212, 2290, 2429, 2496, 3207, 3232, 3826], 'Scholar).': [534, 627, 684, 717, 759, 813, 852, 905, 957, 1170, 1475, 2047, 2100, 2213, 2291, 2430, 2497, 3233], 'Increasing': [535], 'evidence': [536], 'also': [537, 3270, 3399, 3453, 3829], 'shows': [538, 3251], 'implication': [539], 'various': [543], 'physiological': [544], 'functions': [545], 'proliferation': [549], '(2Hoglinger': [550], 'G.U.': [551], 'Rizk': [552], 'Muriel': [554], 'M.P.': [555], 'Duyckaerts': [556], 'C.': [557, 1455, 2080], 'Oertel': [558], 'W.H.': [559], 'Caille': [560], 'I.': [561, 838, 881, 948, 3218], 'Hirsch': [562], 'E.C.': [563], 'Nat.': [564, 2203], 'Neurosci.': [565], '2004;': [566, 1047, 1163, 1463, 1924, 2040, 2088, 2284, 2423, 2490], '7:': [567], '726-735Crossref': [568], '(759)': [571], 'Scholar),': [573, 604, 932, 1054, 3827], 'gastrointestinal': [574], 'protection': [575], '(3Mezey': [576], 'E.': [577], 'Eisenhofer': [578], 'G.': [579, 581, 617, 834, 1041, 1918, 2034, 2278, 2417, 2484], 'Harta': [580], 'Hansson': [582], 'Gould': [584], 'L.': [585], 'Hunyady': [586], 'B.': [587, 613, 804, 946, 1039, 1450, 1916, 2032, 2075, 2276, 2415, 2482, 3818], 'Hoffman': [588], 'B.J.': [589], 'Proc.': [590, 3219], 'Natl.': [591, 3220], 'Acad.': [592, 3221], 'Sci.': [593, 3222], 'U.': [594, 3223], 'A.': [596, 615, 840, 1035, 1453, 1912, 2028, 2078, 2198, 2272, 2411, 2478, 3225], '1996;': [597, 677], '93:': [598], '10377-10382Crossref': [599], '(98)': [602, 1473, 2098], 'prolactin': [608], '(4Freeman': [610], 'M.E.': [611], 'Kanyicska': [612], 'Lerant': [614], 'Nagy': [616], 'Physiol.': [618, 3200], 'Rev.': [619], '2000;': [620, 770, 806, 3820], '80:': [621], '1523-1631Crossref': [622], '(1765)': [625], 'Effects': [628, 3317, 3504, 3649], 'general': [635], 'function': [641], 'particular': [643], 'have': [644], 'been': [645], 'poorly': [646], 'studied.': [647], 'primarily': [655], 'First,': [660], 'equilibrates': [662], 'across': [663], 'plasma': [665, 705, 2794, 2830, 2916], 'phosphorylated': [669], 'glucokinase,': [671], 'initiating': [672], 'glycolysis': [673], '(5Matschinsky': [674], 'F.M.': [675], 'Diabetes.': [676, 769, 924], '45:': [678], '223-241Crossref': [679], '(0)': [682], 'Subsequently,': [685], 'generates': [688], 'ATP,': [689], 'which': [690, 2673], 'promotes': [691], 'closure': [693], 'ATP-sensitive': [695, 2166], 'potassium': [696, 1236], 'channels': [697, 726], 'and,': [698], 'consequence,': [701], '(6Rorsman': [707, 736], 'Diabetologia.': [709, 738, 805, 882, 897, 1162, 3819], '1997;': [710, 739], '40:': [711, 740], '487-495Crossref': [712, 741], '(246)': [715, 744], 'This': [718, 4104], 'leads': [719], 'influx': [722], 'through': [723], 'voltage-gated': [724], 'rise': [729], 'calcium,': [732], 'triggering': [733], 'Scholar,': [746, 890, 2192], '7Lang': [747], 'J.': [748, 750, 1457, 1460, 2082, 2085, 3199], 'Eur.': [749, 843], 'Biochem.': [751], '1999;': [752], '259:': [753], '3-17Crossref': [754], '(277)': [757], 'Additional': [760], 'signals': [761], 'participating': [762], 'amplifying': [765], 'pathway': [766], '(8Henquin': [767], 'J.C.': [768], '49:': [771], '1751-1760Crossref': [772], '(922)': [775], 'Scholar)': [777, 1544, 1931, 3208], 'necessary': [779], 'reproduce': [781], 'sustained': [783], 'elicited': [785], 'glucose.': [787, 3724, 4084], 'can': [794], 'further': [796, 2810], 'modulated': [797], 'parasympathetic': [799], 'sympathetic': [801], 'neurotransmitters': [802], '(9Ahren': [803, 3817], '43:': [807, 1541, 3821], '393-410Crossref': [808, 3822], '(678)': [811, 3825], 'Treatment': [814], 'with': [815, 858, 1072, 1349, 1485, 1508, 1567, 1600, 1635, 1812, 1842, 1865, 1989, 2115, 2145, 2172, 2218, 2236, 2306, 2337, 2365, 2387, 2766, 2785, 2947, 3081, 3355, 3739, 3971, 3978], 'precursor': [817], 'l-dopa': [818, 859], 'humans': [820], 'suffering': [821], 'disease': [824], 'reduces': [825], 'upon': [828, 941, 3844], 'oral': [829], 'tolerance': [831], 'test': [832, 2001], '(10Rosati': [833], 'Maioli': [835], 'Aiello': [837], 'Farris': [839], 'Agnetti': [841], 'V.': [842], 'Neurol.': [844], '1976;': [845], '14:': [846], '229-239Crossref': [847], '(27)': [850], 'In': [853, 906, 989], 'rodents,': [854], 'single': [856], 'injection': [857], 'accumulation': [863, 944], 'responses': [875, 985, 3076, 3430, 3479], '(11Ericson': [876], 'L.E.': [877], 'Hakanson': [878], 'R.': [879], 'Lundquist': [880, 947], '1977;': [883], '13:': [884], '117-124Crossref': [885], '(92)': [888], '12Zern': [891], 'R.T.': [892], 'Bird': [893], 'J.L.': [894], 'Feldman': [895], 'J.M.': [896], '1980;': [898], '18:': [899], '341-346Crossref': [900], '(35)': [903], 'islets,': [908, 1100, 1184, 1426], 'analogues': [909], 'release': [915, 2018, 2069, 3089, 3371], '(13Arneric': [916], 'S.P.': [917], 'Chow': [918], 'S.A.': [919], 'Long': [920], 'J.P.': [921], 'Fischer': [922], 'L.J.': [923], '1984;': [925], '33:': [926], '888-893Crossref': [927], '(17)': [930], 'whereas': [933, 2637], 'one': [934, 3880], 'study': [935, 1131, 4105], 'reports': [936], 'potentiation': [937], 'acute': [942], '(14Ahren': [945], 'Pharmacology.': [949], '1985;': [950], '30:': [951], '71-82Crossref': [952], '(21)': [955], 'Taken': [958], 'whole,': [961], 'these': [962], 'previous': [963], 'studies': [964, 3956], 'suggest': [965], 'directly': [971], 'responsive': [972, 3416, 3814], 'dopamine.': [974, 3703, 3758], 'Here,': [975], 'we': [976, 3521, 3828], 'investigated': [977], 'action.': [988], 'particular,': [990], 'present': [992, 3992, 4126], 'data': [993], 'demonstrate': [994], 'Moreover,': [1003, 2713], 'inhibitory': [1005, 3289], 'predominantly': [1010], 'activation': [1013, 3161, 3514, 3557, 4148], 'family': [1018], 'members.': [1019], 'Cells': [1021, 1210, 1504, 1631, 2233, 2598, 2738], 'Pancreatic': [1023, 1139], 'Islets—INS-1E': [1024], 'used': [1026, 1221, 1373, 1393, 1885, 2227, 2463, 2697, 2868, 2972, 3893, 4060], 'differentiated': [1030], 'clone': [1033], '(15Merglen': [1034, 1911, 2027, 2271, 2410, 2477], 'Theander': [1036, 1913, 2029, 2273, 2412, 2479], 'Rubi': [1038, 1915, 2031, 2275, 2414, 2481], 'Chaffard': [1040, 1917, 2033, 2277, 2416, 2483], 'Wollheim': [1042, 1919, 2035, 2181, 2201, 2279, 2418, 2485], 'C.B.': [1043, 1920, 2036, 2182, 2202, 2280, 2419, 2486], 'Maechler': [1044, 1160, 1458, 1921, 2037, 2083, 2195, 2281, 2420, 2487], 'Endocrinology.': [1046, 1923, 2039, 2283, 2422, 2489], '145:': [1048, 1925, 2041, 2285, 2424, 2491], '667-678Crossref': [1049, 1926, 2042, 2286, 2425, 2492], '(465)': [1052, 1929, 2045, 2289, 2428, 2495], 'were': [1055, 1113, 1141, 1173, 1186, 1341, 1362, 1410, 1428, 1438, 1482, 1505, 1572, 1595, 1604, 1623, 1632, 1795, 1807, 1829, 1840, 1884, 1932, 1986, 2012, 2053, 2159, 2216, 2234, 2297, 2329, 2363, 2385, 2507, 2539, 2573, 2685, 2710, 2717, 2764, 3085, 3181, 3415, 3431, 3452, 3484, 3590, 3733, 3750, 3763, 3858, 4042, 4050, 4125], 'cultured': [1056, 1174, 1199, 1431, 1624, 1907, 2356, 2503], 'humidified': [1059], 'atmosphere': [1060], 'containing': [1061, 1815, 1979, 2063, 2254], '5%': [1062, 1076], 'CO2': [1063], 'medium': [1066, 1179], 'composed': [1067], 'RPMI': [1069, 1177], '1640': [1070, 1178], 'supplemented': [1071], '10': [1073, 1499, 1973, 2116, 3108, 3307, 3311, 3437, 3489, 3701, 3756, 3803], 'mm': [1074, 1091, 1646, 1741, 1955, 1958, 1961, 1964, 1967, 1970, 1974, 2250, 2513, 3039, 3043, 3083, 3237, 3357, 3374, 3534, 3630, 3671, 3731, 3779, 3854, 3864, 3887, 3915, 4078, 4083], 'Hepes,': [1075], '(v/v)': [1077], 'heat-inactivated': [1078], 'fetal': [1079], 'calf': [1080], 'serum,': [1081], '2mm': [1082], 'glutamine,': [1083], '100': [1084, 1087, 2255, 2442, 3063, 3115], 'units/ml': [1085], 'penicillin,': [1086], 'μg/ml': [1088, 2117], 'streptomycin,': [1089], '1': [1090, 1269, 1350, 1589, 1727, 1810, 2237, 2398, 3105, 3853], 'sodium': [1092], 'pyruvate,': [1093], '50': [1095], 'μm': [1096, 1351, 2256, 2308, 3106, 3109, 3116, 3308, 3312, 3438, 3702, 3757, 3804], '2-mercaptoethanol.': [1097], 'For': [1098, 1182, 1419, 2350, 2498], 'Wistar': [1101, 1150], 'rats': [1102, 1151], 'or': [1103, 1152, 1479, 1553, 2511, 3051, 3062, 3186, 4039], 'BALB/c': [1104, 1153], 'mice': [1105, 1154], 'weighing': [1106], '200–250': [1107], 'g': [1108, 1666], '25–30': [1110], 'g,': [1111, 1681], 'respectively,': [1112, 1587], 'obtained': [1114], 'in-house': [1116], 'breeding': [1117], '(CMU-Zootechnie,': [1118], 'Geneva,': [1119], 'Switzerland).': [1120, 1616, 1826], 'followed': [1122, 2801], 'principles': [1124], 'laboratory': [1126], 'animal': [1127], 'care,': [1128], 'approved': [1133], 'responsible': [1136], 'ethics': [1137], 'committee.': [1138], 'collagenase': [1144], 'digestion': [1145], 'handpicking': [1147], 'male': [1149], 'described': [1156], 'previously': [1157], '(16Carobbio': [1158], '47:': [1164], '1856-1857Crossref': [1165], '(3)': [1168], 'Isolated': [1171], 'free-floating': [1175], 'before': [1180, 1628, 1715, 1743, 1800, 1857, 2321], 'experiments.': [1181, 2232], 'pancreata': [1185], 'harvested': [1187], 'braindead': [1189], 'donors': [1190], 'after': [1194, 1364, 2170, 2381], 'enzymatic': [1195], 'ductal': [1196], 'perfusion': [1197], 'non-adherent': [1201], 'dishes.': [1202], 'Expression': [1203, 2590], 'Analysis': [1204, 2591], 'Receptors': [1207, 2594, 3951], 'Rat': [1212, 2600], 'Islets—Total': [1213], 'RNA': [1214, 1273], 'extracted': [1216], 'RT': [1218], '3The': [1219], 'abbreviations': [1220], 'are:': [1222], 'RT,': [1223], 'transcription;': [1225], 'KRBH': [1226, 1991, 1999, 2062, 2240, 2253, 2314, 2396], 'buffer,': [1227], 'Krebs-Ringer': [1228, 1945], 'bicarbonate': [1229, 1946], 'HEPES': [1230, 1947, 1975], 'buffer;': [1231], 'GIRK,': [1232], 'G-protein-coupled': [1233], 'inward': [1234], 'rectifier': [1235], 'channel;': [1237], 'GAPDH,': [1238], 'glyceraldehyde-3-phosphate': [1239, 4023], 'dehydrogenase.': [1240], '-PCR': [1241], 'use': [1250], 'Trizol': [1252], '(Invitrogen).': [1253, 1279], 'Reverse': [1254], 'transcription': [1255], '(see': [1256], 'TABLES': [1257], 'ONE': [1258], 'TWO': [1260], 'list': [1263], 'oligonucleotides)': [1265], 'performed': [1267, 1342, 2330, 2662, 2808, 2932, 2967, 3072, 3182, 4026], 'using': [1268, 1343, 1606, 1776, 2023, 2441, 2804, 4152], 'μg': [1270, 1790], 'total': [1272], 'transcriptase': [1276, 2675, 4038], 'SuperScript': [1277], 'II': [1278], 'The': [1280, 1435, 1656, 1690, 1703, 1752, 1805, 1827, 1873, 2695, 2703, 3288, 3446, 3477, 3684, 4047, 4085], 'PCR': [1281, 1339, 2670, 2681, 4034], 'program': [1282], 'cDNA': [1284], 'follows;': [1287], 'initial': [1288], 'denaturation': [1289, 1300], 'step': [1290, 1325], 'at': [1291, 1301, 1308, 1319, 1329, 1562, 1591, 1664, 1678, 1737, 1748, 1836, 1854, 1862, 1940, 1976, 2122, 2132, 2151, 2246, 2248, 2315, 2340, 2471, 2749, 2907, 3036, 3104, 3235, 3372, 3390, 3628, 3860, 3913, 4052], '94': [1292, 1302], '°C': [1293, 1303, 1331, 1856, 1942, 2124, 2134, 2317], '2': [1295, 1709, 1860, 2307, 2783, 2946, 3969, 3990], 'min,': [1296], '40': [1297], 'cycles': [1298, 1775], '30': [1305, 1312, 1490, 1676, 1938, 1996, 2244, 2516, 3360], 's,': [1306, 1313], 'annealing': [1307], 'specific': [1309, 2174, 2715], 'temperatures': [1310], 'elongation': [1315, 1324], '30–45': [1317], 's': [1318], '72': [1320, 1330], '°C.': [1321, 1564], 'A': [1322, 2995], 'final': [1323], '7': [1327], 'min': [1328, 1491, 1500, 1663, 1677, 1747, 1939, 1997, 2060, 2121, 2245, 2305, 2517, 3361], 'allowed': [1332], 'extension': [1333], 'truncated': [1335], 'product': [1336], 'full-length.': [1338], 'reactions': [1340, 1365, 2671, 2682, 4035], 'Taq': [1344], 'DNA': [1345], 'polymerase': [1346], '(Amersham': [1347], 'Biosciences)': [1348], 'concentrations': [1352, 2444, 3057, 3708], 'each': [1354], 'primer.': [1355], 'Control': [1356], 'experiments': [1357, 2778, 2931, 3071, 3177, 3327, 3689], 'demonstrated': [1358], 'amplification': [1360, 2693, 2708, 2729, 4048], 'products': [1361, 2709, 4049], 'absent': [1363], 'absence': [1368, 3050, 3185], 'transcriptase.TABLE': [1371], 'ONEOligonucleotides': [1372], 'analysis': [1376, 1396], 'RT-PCR': [1378, 1398, 3996], 'INS1-E': [1380, 2596, 3179], 'islets1048ratD1.for5′-GCCTTTGACATCATGTGCTC-3′1644ratD1.rev5′-CAGAAAGGAACCATACAGTTC-3′1029ratD2.for5′-GCAGTCGAGCTTTCAGAGCC-3′1432ratD2.rev5′-TCTGCGGCTCATCGTCTTAAG-3′823ratD3.for5′-CATCCCATTCGGCAGTTTTCA-3′1023ratD3.rev5′-TGGGTGTCTCAAGGCAGTGTCT-3′341ratD4.for5′-CTGCAGACACCCACCAACTA-3′561ratD4.rev5′-CACTGACCCTGCTGGTTGTA-3′782ratD5.for5′-AGCATGCTCAGAGTTGCCGG-3′990ratD5.rev5′-ACAAGGGAAGCCAGTCTTTGG-3′806ratDDC.for5′-GGAACCACATCTTGCTGCTC-3′1051ratDDC.rev5′-GGCTTCGGTTAGGTCAGTTC-3′704ratGAPDH.for5′-AGAACATCATCCCTGCATCC-3′1070ratGAPDH.rev5′-TCCACCACCCTGTTGCTGTA-3′': [1384], 'Open': [1385, 1402], 'table': [1386, 1403], 'new': [1389, 1406], 'tab': [1390, 1407], 'TABLE': [1391, 2701], 'TWOOligonucleotides': [1392], 'islets1414hD1.for5′-CAGTCCACGCCAAGAATTGCC-3′1868hD1.rev5′-ATTGCACTCCTTGGAGATGGAGCC-3′360hD2.for5′-GCAGACCACCACCAACTACC-3′609hD2.rev5′-GGAGCTGTAGCGCGTATTGT-3′2181hD2.for5′-AGGGTCTATGGGGAGAGGAA-3′2419hD2.rev5′-AGAGAGGAAAGGCCAGAAGG-3′1047hD3a.for5′-GCGTTACTACAGCATCTGCCAGGAC-3′1484hD3a.rev5′-AGACAGGATCTTGAGGAAGG-3′963hD4.for5′-CCCACCCCAGACTCCACC-3′1221hD4.rev5′-GAACTCGGCGTTGAAGACAG-3′349hD5.for5′-GTCGCCGAGGTGGCCGGTTAC-3′711hD5.rev5′-GCTGGAGTCACAGTTCTCTGCAT-3′1615hDDC.for5′-CTGTGGCTTCCCATGTCTTT-3′1858hDDC.rev5′-GTTGCGTGAACATTGATTGC-3′58hGAPDH.for5′-GAGTCAACGGATTTGGTCGT-3′303hGAPDH.rev5′-TTGATTTTGGAGGGATCTCG-3′': [1401], 'Immunostaining—INS-1E': [1408], 'grown': [1411], 'polyornithine-treated': [1413, 1446], 'glass': [1414, 1447, 1598], 'coverslips': [1415, 1448], '3': [1417], 'days.': [1418], 'immunofluorescence': [1420], '24–48': [1433], 'h.': [1434], 'islet': [1436, 1480, 2970], 'dispersed': [1440, 2969], 'trypsinization': [1442], 'plated': [1444], 'onto': [1445, 1717, 1802], '(17Rubi': [1449, 2074], 'del': [1451, 2076], 'Arco': [1452, 2077], 'Bartley': [1454, 2079], 'Satrustegui': [1456, 2081], 'Chem.': [1462, 2087], '279:': [1464, 2089], '55659-55666Abstract': [1465, 2090], 'Full': [1466, 1468, 2091, 2093], 'Text': [1467, 1469, 2092, 2094], 'PDF': [1470, 2095], 'Monolayers': [1476], 'rinsed': [1483], 'twice': [1484, 1934], 'phosphate-buffered': [1486, 1568, 1636], 'saline,': [1487, 1569], 'fixed': [1488], '4%': [1494], 'paraformaldehyde,': [1495], 'permeabilized': [1497], '0.1%': [1502, 1816, 1980], 'Triton.': [1503], 'incubated': [1507, 1994, 2054, 2242], 'antibodies,': [1510], 'either': [1511], 'rabbit': [1512, 1844], 'anti-dopamine': [1513, 1845], 'antibody': [1515, 1847, 1893, 2769], 'recognizing': [1517], 'third': [1519], 'intracellular': [1520], 'loop': [1521], 'short': [1524, 2627, 2647], 'long': [1526, 2629, 2649, 2877], 'isoforms': [1527, 2905], '(18Boundy': [1528], 'V.A.': [1529], 'Luedtke': [1530], 'R.R.': [1531], 'Artymyshyn': [1532], 'R.P.': [1533], 'Filtz': [1534], 'T.M.': [1535], 'Molinoff': [1536], 'P.B.': [1537], 'Mol.': [1538], 'Pharmacol.': [1539], '1993;': [1540], '666-676PubMed': [1542], 'D2L': [1545], 'D2S': [1547], '(1:150,': [1548], 'AB5084P,': [1549, 1851], 'Chemicon,': [1550], 'Temecula,': [1551], 'CA)': [1552], 'mouse': [1554, 2936, 2964, 2992, 3457], 'monoclonal': [1555, 2976], 'anti-human': [1556], '(1:600,': [1558], 'I-2018,': [1559], 'Sigma-Aldrich)': [1560], 'overnight': [1561, 1853], '4': [1563, 1855, 3687, 3878], 'After': [1565, 1779], 'rinsing': [1566], 'exposed': [1573, 2508, 4075], 'secondary': [1576], 'antibodies': [1577, 2975], 'goat': [1578, 1584], 'anti-rabbit': [1579, 1866], 'IgG': [1580, 1867], 'fluorescein': [1581], 'isothiocyanate': [1582], 'antimouse': [1585], 'rhodamine,': [1586], 'h': [1590, 1811, 1861, 2229], 'room': [1592, 1837, 1863], 'temperature.': [1593, 1838], 'Coverslips': [1594], 'mounted': [1596], 'slides': [1599], 'Dako,': [1601], 'samples': [1603], 'analyzed': [1605], 'Zeiss': [1608], 'laser': [1609], 'confocal': [1610, 2774], 'microscope': [1611], '(60×,': [1612], 'LSM': [1613], '510,': [1614], 'Zurich,': [1615], 'Cell': [1617, 2204, 2431, 2799, 3653], 'Fractionation': [1618], 'Immunoblotting—INS-1E': [1620], '4–5': [1626], 'days': [1627, 2362], 'fractionation.': [1630], 'washed': [1634, 1694, 1830, 1933, 1987, 2235, 2320], 'saline': [1637, 1814], 'ice,': [1639], 'scraped': [1640], '0.32': [1642, 1712], 'm': [1643, 1713, 1728, 1735], 'sucrose': [1644, 1714, 1720, 1729, 1736], 'Tris-HCl,': [1647], 'pH': [1648, 1738, 1977], '7.5),': [1649], 'homogenized': [1651], 'Teflon-glass': [1654], 'potter.': [1655], 'resulting': [1657, 1704], 'suspension': [1658, 1700], 'centrifuged': [1660, 1674], '15': [1662, 2512, 3042, 3082, 3236, 3533, 3629, 3670, 3730, 3778, 3863, 3886, 3914], '800': [1665], 'pull': [1668], 'down': [1669], 'nuclei,': [1670], 'supernatant': [1672], '18,000': [1679], '×': [1680, 1750], 'thereby': [1682], 'giving': [1683], 'fraction': [1686, 1756, 2918], 'supernatant.': [1689], 'corresponding': [1691, 1765, 2854], 'pellet': [1692, 1705], 'second': [1697], 'run': [1698, 2686, 4043], 'centrifugation.': [1702], 'resuspended': [1707], 'ml': [1710, 1725, 1732, 2238], 'incorporation': [1716], 'continuous': [1719], 'gradient': [1721], 'made': [1722], '5': [1724, 1731, 1960, 3498], '2.2': [1734], '7.5': [1739], 'Tris-HCl)': [1742], 'centrifugation': [1744], '90': [1746, 2304], '100,000': [1749], 'g.': [1751], 'visible': [1753], 'collected': [1758, 2013], 'supernatant,': [1761], 'pellet,': [1764], 'granule': [1768, 2852], 'fraction,': [1769, 2853], 'subjected': [1771, 1796], 'three': [1773, 3070, 3882], 'freeze-thaw': [1774], 'liquid': [1777], 'nitrogen.': [1778], 'Bradford': [1781], 'assay': [1782], 'measurements': [1784, 2325], 'protein': [1786, 1823, 2751], 'concentrations,': [1787], 'fractions': [1788, 2832], '(2': [1789], 'proteins': [1792, 2897], 'per': [1793, 2051], 'lane)': [1794], 'SDS/PAGE': [1798], '(10%)': [1799], 'transfer': [1801], 'nitrocellulose': [1803], 'membranes.': [1804], 'membranes': [1806, 1828], 'blocked': [1808], 'Tris-buffered': [1813], 'Tween': [1817], '20': [1818, 2120, 2228], '3%': [1820], '(w/v)': [1821], 'gelatin': [1822], '(Top-Block,': [1824], 'Juro,': [1825], 'times': [1832], 'Trisbuffered': [1834], 'saline/Tween': [1835], 'Membranes': [1839], 'probed': [1841], '(L/S)': [1849], '(1:300,': [1850], 'Chemicon)': [1852], 'incubation': [1858, 2537, 3847], 'temperature': [1864], 'conjugated': [1868], 'horseradish': [1870], 'peroxidase': [1871], '(1:5000).': [1872], 'signal': [1874], 'detected': [1876, 2883], 'chemiluminescence.': [1878], 'As': [1879, 2820, 3093, 3741, 3842], 'controls,': [1880], 'brain': [1882, 2866], 'homogenates': [1883], 'detection': [1887, 2926], 'GLUT2': [1892, 2925], 'served': [1894], 'parallel': [1896, 2922], 'immunoblotting': [1897, 2803, 2885, 2923], 'assessment': [1899], 'fraction.': [1903], 'Secretion—INS-1E': [1905], '24-well': [1909, 2358, 2505], 'plates': [1910, 2359, 2506], 'preincubated': [1936, 2114, 2302], '37': [1941, 2123, 2133, 2316], 'glucose-free': [1944, 1990], 'buffer': [1948], '(KRBH)': [1949], 'following': [1952, 2541, 3326], 'composition:': [1953], '135': [1954], 'NaCl,': [1956], '3.6': [1957], 'KCl,': [1959], 'NaHCO3,': [1962], '0.5': [1963, 1966], 'NaH2PO4,': [1965], 'MgCl2,': [1968], '1.5': [1969], 'CaCl2,': [1971], '7.4': [1978], 'bovine': [1981], 'serum': [1982], 'albumin.': [1983], 'Next,': [1984], 'once': [1988], 'compounds': [2002, 2530], 'indicated.': [2004, 2532, 2569], 'At': [2005, 2533, 3885], 'end': [2007, 2535], 'incubation,': [2010], 'supernatants': [2011], 'measurement': [2015], 'cellular': [2020, 3131], 'contents': [2022, 3133], 'radioimmunoassay': [2026, 2073], 'Handpicked': [2048], 'tube)': [2052], 'over': [2055, 3031, 3123], 'period': [2057, 3035, 3126, 3848], '60': [2059], 'secretagogues': [2064], 'indicated,': [2066], 'measured': [2071, 2110], 'Mitochondrial': [2101, 2127, 3510], 'Membrane': [2102, 2432, 3654], 'Potential': [2103, 2433], 'Levels—Mitochondrial': [2106], 'rhodamine-123': [2118], 'KRBH.': [2126], 'monitored': [2131, 2160, 2264, 2298, 2404, 2440, 3591, 3734, 3764], 'plate-reader': [2137, 2267, 2333], 'fluorimeter': [2138, 2334], '(Fluostar': [2139, 2269, 2335], 'Optima,': [2140], 'BMG': [2141], 'Labtechnologies,': [2142], 'Offenburg,': [2143], 'Germany)': [2144], 'excitation': [2146, 2344, 2465], 'emission': [2148, 2467], 'filters': [2149, 2338], 'set': [2150, 2339], '485': [2152], '520': [2154], 'nm,': [2155, 2475], 'respectively.': [2156], 'levels': [2158, 2835, 2909, 3589, 3627, 3857, 3900, 3929], 'expressing': [2164, 3594, 3768], 'bioluminescent': [2167], 'probe': [2168, 2448], 'luciferase': [2169], 'infection': [2171], 'viral': [2175, 2382], 'constructs': [2176], '(19Maechler': [2177], 'Wang': [2179], 'H.': [2180, 2194], 'FEBS': [2183], 'Lett.': [2184], '1998;': [2185], '422:': [2186], '328-332Crossref': [2187], '(82)': [2190], '20Ishihara': [2193], 'Gjinovci': [2197], 'Herrera': [2199], 'P.L.': [2200], '5:': [2207], '330-335Crossref': [2208], '(326)': [2211], 'Briefly,': [2214], 'transduced': [2217, 2364], 'AdCA-cLuc,': [2219], '(driving': [2220], 'luciferase)': [2225], 'later': [2230], '37°C': [2247], '2.5': [2249, 2510, 3038, 3668, 3861], 'Glc.': [2251], 'Then,': [2252], 'luciferin': [2257], 'added,': [2259], 'luminescence': [2262, 2402], 'luminometer': [2268, 2409], 'Optima)': [2270, 2336], 'Calcium': [2292], 'Concentration': [2293], 'Measurements—Cytosolic': [2294], 'changes': [2296, 3727, 3796], 'Fura-2AM': [2309], '(Teflab,': [2310], 'Austin,': [2311], 'TX)': [2312], 'experiment.': [2323], 'Ratiometric': [2324], 'Fura-2': [2327], 'fluorescence': [2328, 3680], '510': [2341], 'nm': [2342, 2347, 2443], '340/380': [2346], 'emission.': [2349], 'measurements,': [2353, 2500], '3–4': [2361], 'AdCA-mAeq': [2366], 'adenovirus,': [2367], 'enabling': [2368], 'Ca2+-sensitive': [2372, 3770], 'photoprotein': [2373, 3771], 'aequorin': [2374, 2389, 3772], 'targeted': [2375, 3773], 'mitochondria.': [2378, 3776], 'Twenty': [2379], 'hours': [2380], 'treatment': [2383, 3122], 'loaded': [2386, 2898, 3738], 'prosthetic': [2390], 'group': [2391], 'coelenterazine': [2392], '(2.5': [2393], 'h,': [2399], 'plate': [2407, 2459], 'reader': [2408, 2460], 'cAMP': [2435, 2499, 2546, 3659, 3809, 3838, 3856, 3899, 3928], 'Levels—Cell': [2436], 'fluorescent': [2447, 2773], 'bis-oxonol': [2449], '(bis-(1,3-diethylthiobarbituric': [2450], 'acid)': [2451], 'trimethine': [2452], 'oxonol)': [2453], 'thermostatted': [2456], '(37': [2457], '°C)': [2458], 'fluorimeter.': [2461], 'Filters': [2462], 'had': [2468], 'wavelength': [2469], 'optima': [2470], '544': [2472], '590': [2474], 'respectively': [2476], 'phosphodiesterase': [2523], 'inhibitor': [2524], '3-isobutyl-1-methylxanthine': [2525], '(1': [2526], 'mm)': [2527, 3463, 3599], 'lysed': [2540], "manufacturer's": [2543], 'instructions,': [2544], 'quantification': [2547], 'determined': [2549], 'commercially': [2552], 'available': [2553], 'enzyme': [2554], 'immunoassay': [2555], 'Amersham': [2557], 'Biosciences.': [2558], 'Statistical': [2559], 'Analyses—Data': [2560], 'presented': [2562], 'means': [2565, 3068, 3685], '±': [2566, 3867, 3871, 3903, 3931, 3935], 'S.E.': [2567], 'Differences': [2570], 'between': [2571], 'groups': [2572], 'assessed': [2574, 2743, 2920], "Student's": [2576], 't': [2577], 'test,': [2578], 'p': [2581, 3111, 3118, 3283, 3405, 3425, 3441, 3474, 3492, 3501, 3908], '<': [2582, 3091, 3112, 3119, 3247, 3263, 3284, 3367, 3388, 3406, 3426, 3442, 3475, 3493, 3502, 3633, 3645, 3909, 4069, 4099], '0.05': [2583], 'considered': [2585], 'reflecting': [2587, 3795], 'significant': [2588, 2790], 'variance.': [2589], 'Beta': [2597, 3026, 3324, 3954], 'Islets—RT-PCR': [2601], 'revealed': [2602, 3677, 3957, 3998], 'decarboxylase': [2610, 4012], '(Fig.': [2617, 2796, 2955, 3376, 3459, 3553, 3608, 3682, 3806, 3973, 3984, 4016], '1).': [2618], 'Specifically,': [2619], 'clonal': [2620], 'D1,': [2625, 2645, 4002], 'isoforms,': [2630, 2650], 'D5': [2634, 3165, 4006], 'all': [2641], 'known': [2642], 'receptors:': [2644], 'D3,': [2651], 'D4,': [2652, 4004], 'D5.': [2654], 'Amplification': [2655, 4018], 'housekeeping': [2658, 4021], 'gene': [2659, 4022], '(GAPDH)': [2660], 'guarantee': [2664, 4028], 'integrity': [2665, 4029], 'cDNAs': [2668, 4032, 4041], 'used.': [2669, 4033], 'omitted,': [2677], 'without': [2683, 2789, 4036, 4040], 'cDNAs,': [2684], 'negative': [2688, 4045], 'controls': [2689], 'gave': [2691], 'no': [2692, 3544], 'product.': [2694], 'oligonucleotides': [2696, 4059], 'listed': [2699], 'ONE.': [2702], 'sizes': [2704], '(bp)': [2705], 'expected.': [2712], 'fragments': [2716], 'cut': [2718], 'gel': [2721], 'sequenced,': [2723], 'confirming': [2724], 'identity': [2726], 'products.': [2730], 'Immunodetection': [2731], 'Receptor': [2734], 'Rodent': [2740, 3323], 'Islets—We': [2741], 'next': [2742, 3146], 'level': [2752], 'its': [2759], 'subcellular': [2760], 'localization.': [2761], 'immunostained': [2765], 'anti-D2': [2767], 'visualized': [2771], 'microscopy.': [2775], 'Double': [2776, 2929], 'labeling': [2777, 2791, 2930], 'colocalized': [2784], 'insulin-containing': [2786, 2948], '2,': [2797], 'A–C).': [2798], 'fractionation': [2800], 'question': [2811], 'this': [2812, 3172], 'unexpected': [2813], '2.': [2819, 2839], 'shown': [2821, 3094, 3568, 3742], 'Fig.': [2823, 3096, 3249, 3286, 3408, 3444, 3570, 3635, 3647, 3744], '2D,': [2824], 'neither': [2825], 'cytoplasmic': [2827], 'nor': [2828, 3921], 'contained': [2833], 'detectable': [2834], 'contrary,': [2842, 3621], 'band': [2844, 2858], '∼64': [2846], 'kDa': [2847], 'observed': [2849], 'upper': [2857], 'doublet': [2861], 'exhibited': [2862, 3543, 3641, 3783], 'extract': [2867], 'here': [2869], 'positive': [2871, 3896], 'control.': [2872], 'Therefore,': [2873, 3572], 'only': [2874], 'isoform': [2878], 'Nonetheless,': [2890], 'according': [2891, 4056], 'relatively': [2893], 'low': [2894], 'amounts': [2895], 'gels,': [2900], 'lower': [2908], 'cannot': [2910], 'excluded.': [2912], 'Quality': [2913], '(not': [2927, 3134], 'shown).': [2928, 3135, 3316], 'origin': [2939], 'colocalization': [2942], '3).FIGURE': [2956], '3Immunostaining': [2957], 'Immunostaining': [2966], 'anti-insulin': [2977], '(red': [2978], 'staining)': [2979], 'polyclonal': [2981], 'anti': [2982], '(green': [2985], 'staining).': [2986], 'A–C,': [2987], 'D–F,': [2991], 'D,': [2997], 'staining.': [2999, 3005], 'B': [3000], 'E,': [3002], 'C': [3006], 'F,': [3008], 'overlay.View': [3009], 'Large': [3010], 'Image': [3011], 'Figure': [3012], 'ViewerDownload': [3013], 'Hi-res': [3014], 'image': [3015], 'Download': [3016], '(PPT)': [3017], 'Effect': [3018, 3136], 'Secretion': [3023], 'Cells—Insulin': [3027], '30-min': [3033, 3125, 3846], 'basal': [3037, 3088, 3370, 3423, 3472, 4081], 'stimulatory': [3041, 3391, 3481], 'increasing': [3056], '(1,': [3060], '10,': [3061], 'μm).': [3064], 'Results': [3065], 'quadruplicate.': [3074], 'Secretory': [3075], 'stimulated': [3080, 3239, 3464, 4066], '3.6-fold': [3086], 'versus': [3087, 3341, 3369, 3422, 3471, 3869, 3911, 4080], '(p': [3090, 3246, 3262, 3366, 3387, 3632, 3644, 4068, 4098], '0.05).': [3092, 3120, 3264, 3503], '4A,': [3097], 'dose-dependently': [3099], '(-33%),': [3107], '(-56%,': [3110], '0.05),': [3113, 3427], '(-76%,': [3117], 'change': [3130], 'D2/D3': [3138, 3190, 3394], 'D1/D5': [3140, 3210, 3265], 'Agonists': [3141], 'Glucose-stimulated': [3143], 'Secretion—We': [3145], 'if': [3148], 'mimicked': [3158], 'selected': [3160], 'To': [3171], 'end,': [3173], '(21Lacey': [3193], 'M.G.': [3194], 'Mercuri': [3195], 'N.B.': [3196], 'North': [3197], 'R.A.': [3198], '(Lond.).': [3201], '1987;': [3202], '392:': [3203], '397-416Crossref': [3204], '(491)': [3206], 'SKF38393': [3212, 3267], '(22Memo': [3213], 'Lovenberg': [3215], 'W.': [3216], 'Hanbauer': [3217], '1982;': [3226], '79:': [3227], '4456-4460Crossref': [3228], '(59)': [3231], 'Incubation': [3234], 'control': [3243, 3468, 3912], '5.4-fold': [3245], '0.01).': [3248, 3476], '4B': [3250], '43%': [3261], 'response': [3274, 3722], 'glucose,': [3276, 3424, 3888], 'although': [3277], 'lesser': [3280], 'extent': [3281], '(-26%,': [3282], '0.01,': [3285], '4C).': [3287], 'affected': [3298, 3560], 'when': [3299], 'blocking': [3300], 'GABA-A': [3301], 'N-methyl-d-aspartate': [3304], 'AP-5': [3309], 'bicuculline': [3313], '(data': [3314], 'Quinpirole': [3321, 3508], 'Cells—The': [3325], 'compared': [3328], 'sorter-purified': [3344, 3412], 'rats.': [3349], 'Stimulation': [3350], '16.7': [3356, 4077], 'increased': [3362, 3600, 3625], '4.5-fold': [3365], '0.0001)': [3368], '2.8': [3373, 4082], '5A).': [3377], '59%': [3386], '0.001)': [3389], 'concentrations.': [3393], '(-50%,': [3404], '0.05,': [3407, 3443, 3634, 3646, 4100], '5B).': [3409], 'Fluorescence-activated': [3410], '(6.3-fold': [3421], 'addition': [3435], '(-41%,': [3440], '5C).': [3445], '5D).': [3460], 'Glucose': [3461, 3597], '(22.8': [3462], '(4.2-fold': [3470], 'concentration': [3483], '(at': [3488, 3497], 'μm,': [3490, 3499], '-73%,': [3491], '0.01)': [3494], '-58%,': [3500], 'Activation—': [3511], 'Because': [3512, 3808], 'mandatory': [3516], 'induced': [3531, 3672], '6A).': [3554], 'Respiratory': [3555], 'chain': [3556], '(up': [3563], '25': [3565], '6B.': [3571], 'quinpirole,': [3575], 'conditions': [3577], 'inhibiting': [3578], 'do': [3581], 'affect': [3583], 'hyperpolarization.': [3586], 'Cellular': [3587], 'luciferase.': [3596], '(15': [3598], 'expected': [3607, 4054], '6C).': [3609], 'generation.': [3618], '6C),': [3636], 'similar': [3642, 3859], '6D).': [3648], 'Potential,': [3655], 'Ca2+': [3656, 3707, 3726, 3748, 3761, 3793], 'Levels,': [3657], 'Generation': [3660], 'Cells—As': [3663], 'expected,': [3664, 3843], 'raising': [3665], 'depolarization,': [3675], 'bisoxonol': [3679], 'recordings': [3681], '7A).': [3683], 'independent': [3688, 3883], 'indicated': [3690], 'Elevation': [3704], 'consequence': [3711], 'required': [3718], 'Cytosolic': [3725], 'Fura2-AM.': [3740], '7B,': [3745], 'augmentations': [3749, 3762], 'reduced': [3751, 3801, 3927], 'Glucose-induced': [3759], 'Upon': [3777], 'stimulation,': [3781], 'biphasic': [3785], 'increase': [3786], 'Ca2+.': [3789], 'First-phase': [3790], 'rise,': [3794], 'Ca2+,': [3799], '7C).': [3807], 'renders': [3810], 'more': [3813], 'possible': [3833], 'target': [3835], 'quantifying': [3837], '3-isobutyl-1-methylxanthine,': [3855], '(27.9': [3866], '1.0': [3868], '30.3': [3870], '3.4': [3872], 'fmol/μg': [3873, 3905, 3937], 'protein,': [3874, 3907, 3939], 'respectively;': [3875], 'n': [3876, 4101], '=': [3877, 4102], 'experiments).': [3884], 'glucagon-like': [3889], 'peptide-1': [3890], 'nm),': [3892], 'control,': [3897], 'raised': [3898], '7.3-fold': [3901], '(221.5': [3902], '47.8': [3904], '0.001': [3910], 'glucose).': [3916], 'Neither': [3917], '(45.2': [3930], '8.5': [3932], '48.7': [3934], '7.3': [3936], 'respectively),': [3940], 'arguing': [3941], 'against': [3942], 'cAMP-mediated': [3943], 'Human': [3953], 'Cells—Immunostaining': [3955], 'co-localized': [3970], '8A),': [3974], 'good': [3976], 'agreement': [3977], 'observations': [3979], '3),': [3985], 'showing': [3986], 'granules.': [3995], 'analyses': [3997], 'D2,': [4003], '8B).': [4017], 'dehydrogenase': [4024], 'controls.': [4046], 'found': [4051], 'size,': [4055], '(TABLE': [4061], 'TWO).': [4062], '3.1-fold': [4067], '0.05)': [4070], '46%': [4097], '5).': [4103], 'provides': [4106], 'basis': [4108], 'mediating': [4112], 'reproduced': [4146], '2/3': [4155], 'ago': [4157]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2066583605', 'counts_by_year': [{'year': 2024, 'cited_by_count': 17}, {'year': 2023, 'cited_by_count': 10}, {'year': 2022, 'cited_by_count': 13}, {'year': 2021, 'cited_by_count': 16}, {'year': 2020, 'cited_by_count': 13}, {'year': 2019, 'cited_by_count': 22}, {'year': 2018, 'cited_by_count': 13}, {'year': 2017, 'cited_by_count': 13}, {'year': 2016, 'cited_by_count': 15}, {'year': 2015, 'cited_by_count': 16}, {'year': 2014, 'cited_by_count': 10}, {'year': 2013, 'cited_by_count': 11}, {'year': 2012, 'cited_by_count': 13}], 'updated_date': '2024-12-31T11:32:04.600553', 'created_date': '2016-06-24'}
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