Title: Cytotoxic 5-Hydroxyindole Alkaloids from the Marine Sponge<i>Scalarispongia</i>sp.
Abstract: Journal of Heterocyclic ChemistryVolume 50, Issue 6 p. 1400-1404 Note Cytotoxic 5-Hydroxyindole Alkaloids from the Marine Sponge Scalarispongia sp. Yeon-Ju Lee, Yeon-Ju Lee Korea Ocean Research and Development Institute, Ansan, 426-744 KoreaSearch for more papers by this authorDong-Geun Lee, Dong-Geun Lee Korea Ocean Research and Development Institute, Ansan, 426-744 KoreaSearch for more papers by this authorHyun Soo Rho, Hyun Soo Rho Korea Ocean Research and Development Institute, Ansan, 426-744 KoreaSearch for more papers by this authorVladimir B. Krasokhin, Vladimir B. Krasokhin Pacific Institute of Bioorganic Chemistry of the RAS, Vladivostok, 690022 RussiaSearch for more papers by this authorHee Jae Shin, Hee Jae Shin Korea Ocean Research and Development Institute, Ansan, 426-744 KoreaSearch for more papers by this authorJong Seok Lee, Jong Seok Lee Korea Ocean Research and Development Institute, Ansan, 426-744 KoreaSearch for more papers by this authorHyi-Seung Lee, Hyi-Seung Lee Korea Ocean Research and Development Institute, Ansan, 426-744 KoreaSearch for more papers by this author Yeon-Ju Lee, Yeon-Ju Lee Korea Ocean Research and Development Institute, Ansan, 426-744 KoreaSearch for more papers by this authorDong-Geun Lee, Dong-Geun Lee Korea Ocean Research and Development Institute, Ansan, 426-744 KoreaSearch for more papers by this authorHyun Soo Rho, Hyun Soo Rho Korea Ocean Research and Development Institute, Ansan, 426-744 KoreaSearch for more papers by this authorVladimir B. Krasokhin, Vladimir B. Krasokhin Pacific Institute of Bioorganic Chemistry of the RAS, Vladivostok, 690022 RussiaSearch for more papers by this authorHee Jae Shin, Hee Jae Shin Korea Ocean Research and Development Institute, Ansan, 426-744 KoreaSearch for more papers by this authorJong Seok Lee, Jong Seok Lee Korea Ocean Research and Development Institute, Ansan, 426-744 KoreaSearch for more papers by this authorHyi-Seung Lee, Hyi-Seung Lee Korea Ocean Research and Development Institute, Ansan, 426-744 KoreaSearch for more papers by this author First published: 06 September 2013 https://doi.org/10.1002/jhet.1599Citations: 22 E-mail: [email protected] or [email protected] Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Abstract Three new 5-hydroxyindole alkaloids (1, 2, 3) along with seven known analogs (4, 5, 6, 7, 8, 9, 10) were isolated from a Dokdo marine sponge Scalarispongia sp. The elucidation of the structures of the new compounds by spectroscopic analyses indicated that these compounds were an indole glyoxylate (1), a mono-indole analog of hyrtinadine A (2), and a symmetrical bis-indole with pyridine linker (3). The comparison of IC50 values for obtained compounds against a human leukemia cell line revealed that the bis-indole structure is a requirement for cytotoxicity. Citing Literature Volume50, Issue6November 2013Pages 1400-1404 RelatedInformation
Publication Year: 2013
Publication Date: 2013-09-06
Language: en
Type: article
Indexed In: ['crossref']
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Cited By Count: 24
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