Publication Information

{'id': 'https://openalex.org/W2066395665', 'doi': 'https://doi.org/10.1074/jbc.274.33.22903', 'title': 'Arachidonic Acid Oxygenation by COX-1 and COX-2', 'display_name': 'Arachidonic Acid Oxygenation by COX-1 and COX-2', 'publication_year': 1999, 'publication_date': '1999-08-01', 'ids': {'openalex': 'https://openalex.org/W2066395665', 'doi': 'https://doi.org/10.1074/jbc.274.33.22903', 'mag': '2066395665', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/10438452'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1074/jbc.274.33.22903', 'pdf_url': 'http://www.jbc.org/article/S0021925819652324/pdf', 'source': {'id': 'https://openalex.org/S140251998', 'display_name': 'Journal of Biological Chemistry', 'issn_l': '0021-9258', 'issn': ['0021-9258', '1067-8816', '1083-351X'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'review', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'hybrid', 'oa_url': 'http://www.jbc.org/article/S0021925819652324/pdf', 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5089031929', 'display_name': 'Lawrence J. Marnett', 'orcid': 'https://orcid.org/0000-0002-7834-6285'}, 'institutions': [{'id': 'https://openalex.org/I200719446', 'display_name': 'Vanderbilt University', 'ror': 'https://ror.org/02vm5rt34', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I200719446']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Lawrence J. Marnett', 'raw_affiliation_strings': ['Departments of Biochemistry and Chemistry, Center in Molecular Toxicology, the Vanderbilt Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA.'], 'affiliations': [{'raw_affiliation_string': 'Departments of Biochemistry and Chemistry, Center in Molecular Toxicology, the Vanderbilt Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA.', 'institution_ids': ['https://openalex.org/I200719446']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5113683290', 'display_name': 'Scott W. Rowlinson', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I200719446', 'display_name': 'Vanderbilt University', 'ror': 'https://ror.org/02vm5rt34', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I200719446']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Scott W. Rowlinson', 'raw_affiliation_strings': ['From the Departments of Biochemistry and Chemistry, Center in Molecular Toxicology, and the Vanderbilt Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee 37232'], 'affiliations': [{'raw_affiliation_string': 'From the Departments of Biochemistry and Chemistry, Center in Molecular Toxicology, and the Vanderbilt Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee 37232', 'institution_ids': ['https://openalex.org/I200719446']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5043881366', 'display_name': 'Douglas C. Goodwin', 'orcid': 'https://orcid.org/0000-0002-7869-7704'}, 'institutions': [{'id': 'https://openalex.org/I200719446', 'display_name': 'Vanderbilt University', 'ror': 'https://ror.org/02vm5rt34', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I200719446']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Douglas C. Goodwin', 'raw_affiliation_strings': ['From the Departments of Biochemistry and Chemistry, Center in Molecular Toxicology, and the Vanderbilt Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee 37232'], 'affiliations': [{'raw_affiliation_string': 'From the Departments of Biochemistry and Chemistry, Center in Molecular Toxicology, and the Vanderbilt Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee 37232', 'institution_ids': ['https://openalex.org/I200719446']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5090896472', 'display_name': 'Amit S. Kalgutkar', 'orcid': 'https://orcid.org/0000-0001-9701-756X'}, 'institutions': [{'id': 'https://openalex.org/I200719446', 'display_name': 'Vanderbilt University', 'ror': 'https://ror.org/02vm5rt34', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I200719446']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Amit S. Kalgutkar', 'raw_affiliation_strings': ['From the Departments of Biochemistry and Chemistry, Center in Molecular Toxicology, and the Vanderbilt Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee 37232'], 'affiliations': [{'raw_affiliation_string': 'From the Departments of Biochemistry and Chemistry, Center in Molecular Toxicology, and the Vanderbilt Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee 37232', 'institution_ids': ['https://openalex.org/I200719446']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5016356489', 'display_name': 'Cheryl A. Lanzo', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I200719446', 'display_name': 'Vanderbilt University', 'ror': 'https://ror.org/02vm5rt34', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I200719446']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Cheryl A. Lanzo', 'raw_affiliation_strings': ['From the Departments of Biochemistry and Chemistry, Center in Molecular Toxicology, and the Vanderbilt Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee 37232'], 'affiliations': [{'raw_affiliation_string': 'From the Departments of Biochemistry and Chemistry, Center in Molecular Toxicology, and the Vanderbilt Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee 37232', 'institution_ids': ['https://openalex.org/I200719446']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 2500, 'currency': 'USD', 'value_usd': 2500, 'provenance': 'doaj'}, 'apc_paid': {'value': 2500, 'currency': 'USD', 'value_usd': 2500, 'provenance': 'doaj'}, 'fwci': 6.225, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 519, 'citation_normalized_percentile': {'value': 0.996226, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 99, 'max': 100}, 'biblio': {'volume': '274', 'issue': '33', 'first_page': '22903', 'last_page': '22906'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10678', 'display_name': 'Inflammatory mediators and NSAID effects', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2736', 'display_name': 'Pharmacology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10678', 'display_name': 'Inflammatory mediators and NSAID effects', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2736', 'display_name': 'Pharmacology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10375', 'display_name': 'Pharmacogenetics and Drug Metabolism', 'score': 0.9975, 'subfield': {'id': 'https://openalex.org/subfields/3004', 'display_name': 'Pharmacology'}, 'field': {'id': 'https://openalex.org/fields/30', 'display_name': 'Pharmacology, Toxicology and Pharmaceutics'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T13736', 'display_name': 'Steroid Chemistry and Biochemistry', 'score': 0.9972, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [], 'concepts': [{'id': 'https://openalex.org/C2778078955', 'wikidata': 'https://www.wikidata.org/wiki/Q407699', 'display_name': 'Arachidonic acid', 'level': 3, 'score': 0.7296556}, {'id': 'https://openalex.org/C2779689624', 'wikidata': 'https://www.wikidata.org/wiki/Q410251', 'display_name': 'Cyclooxygenase', 'level': 3, 'score': 0.67809194}, {'id': 'https://openalex.org/C2780664492', 'wikidata': 'https://www.wikidata.org/wiki/Q209717', 'display_name': 'Prostaglandin', 'level': 2, 'score': 0.6627922}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.55060333}, {'id': 'https://openalex.org/C19038510', 'wikidata': 'https://www.wikidata.org/wiki/Q2005087', 'display_name': 'Polyunsaturated fatty acid', 'level': 3, 'score': 0.5432637}, {'id': 'https://openalex.org/C181199279', 'wikidata': 'https://www.wikidata.org/wiki/Q8047', 'display_name': 'Enzyme', 'level': 2, 'score': 0.5091192}, {'id': 'https://openalex.org/C553450214', 'wikidata': 'https://www.wikidata.org/wiki/Q851162', 'display_name': 'Biosynthesis', 'level': 3, 'score': 0.44234502}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.41544488}, {'id': 'https://openalex.org/C543025807', 'wikidata': 'https://www.wikidata.org/wiki/Q61476', 'display_name': 'Fatty acid', 'level': 2, 'score': 0.38912663}, {'id': 'https://openalex.org/C71240020', 'wikidata': 'https://www.wikidata.org/wiki/Q186011', 'display_name': 'Stereochemistry', 'level': 1, 'score': 0.34115133}], 'mesh': [{'descriptor_ui': 'D016718', 'descriptor_name': 'Arachidonic Acid', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D007527', 'descriptor_name': 'Isoenzymes', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D010100', 'descriptor_name': 'Oxygen', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D011451', 'descriptor_name': 'Prostaglandin-Endoperoxide Synthases', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016718', 'descriptor_name': 'Arachidonic Acid', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002384', 'descriptor_name': 'Catalysis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051545', 'descriptor_name': 'Cyclooxygenase 1', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051546', 'descriptor_name': 'Cyclooxygenase 2', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D052246', 'descriptor_name': 'Cyclooxygenase 2 Inhibitors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016861', 'descriptor_name': 'Cyclooxygenase Inhibitors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016861', 'descriptor_name': 'Cyclooxygenase Inhibitors', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007527', 'descriptor_name': 'Isoenzymes', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007527', 'descriptor_name': 'Isoenzymes', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D008565', 'descriptor_name': 'Membrane Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008958', 'descriptor_name': 'Models, Molecular', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010100', 'descriptor_name': 'Oxygen', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011451', 'descriptor_name': 'Prostaglandin-Endoperoxide Synthases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011451', 'descriptor_name': 'Prostaglandin-Endoperoxide Synthases', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1074/jbc.274.33.22903', 'pdf_url': 'http://www.jbc.org/article/S0021925819652324/pdf', 'source': {'id': 'https://openalex.org/S140251998', 'display_name': 'Journal of Biological Chemistry', 'issn_l': '0021-9258', 'issn': ['0021-9258', '1067-8816', '1083-351X'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/10438452', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1074/jbc.274.33.22903', 'pdf_url': 'http://www.jbc.org/article/S0021925819652324/pdf', 'source': {'id': 'https://openalex.org/S140251998', 'display_name': 'Journal of Biological Chemistry', 'issn_l': '0021-9258', 'issn': ['0021-9258', '1067-8816', '1083-351X'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'score': 0.55, 'id': 'https://metadata.un.org/sdg/6', 'display_name': 'Clean water and sanitation'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 58, 'referenced_works': ['https://openalex.org/W1485442945', 'https://openalex.org/W1488935046', 'https://openalex.org/W1490343139', 'https://openalex.org/W1490609633', 'https://openalex.org/W1520750411', 'https://openalex.org/W1531513729', 'https://openalex.org/W1536572717', 'https://openalex.org/W1556997704', 'https://openalex.org/W1586663904', 'https://openalex.org/W1594307292', 'https://openalex.org/W1660326086', 'https://openalex.org/W1722902827', 'https://openalex.org/W1902547891', 'https://openalex.org/W1964533656', 'https://openalex.org/W1970287261', 'https://openalex.org/W1976654542', 'https://openalex.org/W1977550995', 'https://openalex.org/W1978734258', 'https://openalex.org/W1983759759', 'https://openalex.org/W1987212025', 'https://openalex.org/W1992102726', 'https://openalex.org/W1993432693', 'https://openalex.org/W1997364548', 'https://openalex.org/W1997761684', 'https://openalex.org/W2001978048', 'https://openalex.org/W2003684583', 'https://openalex.org/W2008574207', 'https://openalex.org/W2009132110', 'https://openalex.org/W2010694924', 'https://openalex.org/W2014951049', 'https://openalex.org/W2015850083', 'https://openalex.org/W2021745376', 'https://openalex.org/W2023200971', 'https://openalex.org/W2024001803', 'https://openalex.org/W2030850720', 'https://openalex.org/W2031752627', 'https://openalex.org/W2032839609', 'https://openalex.org/W2036800888', 'https://openalex.org/W2039358393', 'https://openalex.org/W2040981816', 'https://openalex.org/W2048234380', 'https://openalex.org/W2053797921', 'https://openalex.org/W2059750485', 'https://openalex.org/W2060807115', 'https://openalex.org/W2061592031', 'https://openalex.org/W2062942163', 'https://openalex.org/W2063837435', 'https://openalex.org/W2064498341', 'https://openalex.org/W2071112954', 'https://openalex.org/W2071338491', 'https://openalex.org/W2078715730', 'https://openalex.org/W2087537112', 'https://openalex.org/W2113745276', 'https://openalex.org/W2115350007', 'https://openalex.org/W2134732424', 'https://openalex.org/W2149233326', 'https://openalex.org/W2894728782', 'https://openalex.org/W4234941515'], 'related_works': ['https://openalex.org/W2997900863', 'https://openalex.org/W2461912830', 'https://openalex.org/W2438123340', 'https://openalex.org/W2109676304', 'https://openalex.org/W2091479157', 'https://openalex.org/W2067101407', 'https://openalex.org/W2050532610', 'https://openalex.org/W2039123883', 'https://openalex.org/W2005860484', 'https://openalex.org/W1968233993'], 'abstract_inverted_index': {'cyclooxygenase': [0, 153, 157, 371, 1303, 1457, 1519, 1555, 1582, 1738, 1874, 1962, 3162, 3684, 4017], 'protein': [1, 377, 675, 972, 2710, 2735, 3079, 3793, 4033], 'or': [2, 165, 357, 1266, 1309, 1428, 1585, 3075, 3646], 'the': [3, 77, 117, 134, 141, 162, 169, 176, 181, 196, 298, 348, 373, 383, 389, 394, 507, 519, 588, 608, 630, 640, 650, 660, 665, 681, 723, 726, 824, 901, 947, 953, 957, 963, 971, 1100, 1170, 1219, 1225, 1280, 1293, 1300, 1342, 1354, 1368, 1374, 1378, 1477, 1554, 1572, 1578, 1628, 1631, 1636, 1639, 1644, 1707, 1720, 1730, 1734, 1751, 1816, 1833, 1846, 1855, 1863, 1873, 1935, 1941, 1949, 1958, 1961, 1969, 1972, 1979, 1983, 2030, 2040, 2049, 2070, 2076, 2080, 2092, 2095, 2100, 2104, 2108, 2131, 2144, 2148, 2168, 2196, 2264, 2267, 2282, 2297, 2356, 2360, 2428, 2431, 2434, 2439, 2456, 2496, 2499, 2517, 2624, 2629, 2669, 2672, 2677, 2683, 2690, 2694, 2705, 2727, 2734, 2984, 2994, 3068, 3078, 3157, 3161, 3166, 3170, 3173, 3178, 3203, 3241, 3244, 3251, 3262, 3294, 3300, 3313, 3319, 3325, 3344, 3350, 3361, 3416, 3460, 3470, 3501, 3601, 3644, 3650, 3656, 3676, 3680, 3683, 3700, 3712, 3715, 3772, 3780, 3783, 3789, 3792, 3795, 3814, 3823, 3841, 3889, 3901, 3924, 3927, 3930, 3937, 3973, 3989, 4007, 4050, 4103, 4134, 4163, 4172, 4225, 4294, 4304, 4321, 4368, 4371, 4380, 4387, 4393, 4400, 4412], 'gene': [4, 366], 'that': [5, 173, 183, 269, 279, 375, 391, 509, 590, 610, 684, 816, 1073, 1259, 1279, 1312, 1352, 1387, 1479, 1537, 1633, 1797, 1815, 1826, 1965, 2039, 2065, 2094, 2154, 2179, 2292, 2731, 2830, 3346, 3360, 3492, 3699, 3822, 3891, 4053, 4067, 4282], 'codes': [6], 'for': [7, 30, 172, 370, 1038, 1116, 1128, 1132, 1287, 1299, 1367, 1454, 1733, 2120, 2133, 2143, 2279, 2290, 2347, 2437, 2722, 2834, 3250, 3353, 3666, 3755, 3794, 3800, 3915, 4012, 4063, 4117, 4234, 4311, 4330, 4370, 4392, 4431, 4449, 4461, 4469], 'it': [8, 58, 671, 915, 2180, 2766, 4279], 'non-steroidal': [9, 270], 'anti-inflammatory': [10, 271, 289, 514], 'drugs': [11, 272], 'prostaglandin': [12, 90, 199, 275, 358, 1442, 1472, 1484], 'G2': [13], 'Prostaglandins': [14], 'were': [15, 56], 'discovered': [16, 385], 'in': [17, 20, 94, 123, 129, 201, 254, 284, 291, 323, 946, 970, 1042, 1099, 1377, 1456, 1459, 1486, 1489, 1524, 1541, 1557, 1710, 1821, 1828, 1901, 2034, 2052, 2163, 2178, 2276, 2490, 2526, 2622, 2628, 2681, 2698, 3071, 3317, 3336, 3364, 3463, 3704, 3759, 3830, 3876, 3982, 3984, 4005, 4035, 4121, 4171, 4179, 4239, 4248, 4379], 'human': [18, 2893, 3690, 4249, 4438], 'semen': [19], '1930,': [21], 'but': [22, 303, 517, 2123, 2461, 3338, 3517, 4042, 4102, 4424], 'their': [23, 130, 280, 288, 305, 403, 1039, 2470, 3354, 3916, 4003], 'low': [24], 'concentrations': [25, 1381], 'and': [26, 76, 98, 116, 190, 277, 312, 316, 330, 340, 372, 515, 623, 633, 663, 716, 813, 908, 960, 1103, 1120, 1236, 1276, 1360, 1372, 1385, 1434, 1471, 1474, 1531, 1749, 1843, 1867, 1904, 1934, 2335, 2481, 2523, 2611, 2702, 2765, 2836, 2892, 2897, 3148, 3154, 3205, 3209, 3291, 3410, 3415, 3490, 3504, 3641, 3751, 3872, 3879, 3934, 3980, 4001, 4026, 4092, 4099, 4124, 4165, 4229, 4245, 4333, 4342, 4360, 4399, 4446, 4452, 4458, 4466], 'instability': [27], 'precluded': [28], 'identification': [29], 'nearly': [31], '30': [32], 'years': [33, 4297], '(for': [34], 'a': [35, 68, 241, 324, 364, 596, 1046, 1068, 1177, 1271, 1452, 1465, 1798, 1822, 1884, 1898, 1955, 2053, 2124, 2151, 2273, 2502, 2507, 2708, 3143, 3368, 3694, 3831, 3913, 3985, 4020, 4045, 4211, 4240, 4283, 4301, 4435], 'brief': [36], 'historical': [37], 'review,': [38], 'see': [39], 'Ref.': [40], '1Bindra': [41], 'J.S.': [42, 1051, 1136], 'Bindra': [43], 'R.': [44, 690, 692, 1239, 2333, 3723, 3846, 4444], 'Prostaglandin': [45], 'Synthesis.': [46], 'Academic': [47], 'Press,': [48], 'New': [49, 259, 3885], 'York1977:': [50], '7-22Crossref': [51], 'Google': [52, 114, 220, 235, 267, 431, 456, 478, 498, 557, 583, 706, 761, 779, 805, 842, 865, 898, 938, 1001, 1031, 1064, 1093, 1149, 1166, 1206, 1253, 1337, 1417, 1514, 1604, 1619, 1666, 1681, 1704, 1768, 1791, 1932, 2020, 2239, 2260, 2324, 2393, 2414, 2544, 2557, 2572, 2589, 2663, 2755, 2798, 2820, 2859, 2881, 2920, 2943, 2976, 3029, 3046, 3063, 3111, 3137, 3195, 3234, 3288, 3408, 3452, 3548, 3574, 3598, 3636, 3967, 4085, 4154, 4206, 4275], 'Scholar).': [53, 236, 499, 584, 707, 806, 899, 939, 1032, 1065, 1094, 1167, 1207, 1338, 1418, 1515, 1620, 1705, 1792, 2021, 2261, 2325, 2415, 2590, 2664, 2756, 2821, 2882, 2977, 3064, 3138, 3196, 3235, 3289, 3453, 3599, 3637, 3887, 3968, 4086, 4155, 4276], 'Once': [54], 'they': [55, 61, 730, 1277, 4167, 4176, 4208], 'identified,': [57], 'was': [59, 92, 133, 193, 1891, 1938, 1952, 2025, 2116, 2443, 2828], 'clear': [60, 2038, 2161], 'arose': [62], 'from': [63, 83, 382, 402, 1432, 1805, 2107, 3165, 3900, 4097, 4219], 'polyunsaturated': [64, 145, 2184], 'fatty': [65, 146, 825, 1267, 1391, 1950, 2041, 2105, 2185, 2463], 'acids': [66, 2186, 2464, 4336], 'by': [67, 96, 195, 347, 406, 506, 595, 1292, 1390, 1422, 1444, 1588, 1726, 1837, 1986, 1989, 2446, 3083, 3375, 3515, 3610, 3661, 3668, 3771, 4216, 4300, 4402], 'complex': [69, 187, 1179, 2024, 2675, 3316, 3820, 4132], 'series': [70], 'of': [71, 79, 89, 136, 144, 198, 301, 328, 335, 350, 363, 393, 397, 408, 626, 636, 639, 644, 653, 667, 725, 733, 810, 941, 949, 956, 965, 1070, 1078, 1108, 1169, 1172, 1184, 1211, 1221, 1228, 1232, 1261, 1295, 1302, 1305, 1316, 1341, 1357, 1370, 1380, 1382, 1518, 1553, 1580, 1630, 1638, 1646, 1649, 1713, 1719, 1724, 1737, 1753, 1801, 1832, 1854, 1877, 1944, 1948, 1960, 1971, 1976, 2061, 2079, 2103, 2110, 2147, 2199, 2270, 2285, 2362, 2427, 2433, 2441, 2448, 2458, 2498, 2516, 2596, 2602, 2671, 2693, 2707, 2885, 2887, 2987, 2996, 3067, 3142, 3160, 3172, 3198, 3243, 3257, 3293, 3303, 3308, 3372, 3419, 3469, 3472, 3476, 3496, 3639, 3643, 3659, 3682, 3689, 3714, 3782, 3791, 3807, 3816, 3906, 3929, 3972, 4009, 4023, 4032, 4047, 4060, 4090, 4105, 4243, 4286, 4288, 4303, 4363, 4373, 4389, 4437, 4463], 'reactions': [72], 'involving': [73], 'oxygenation,': [74], 'cyclization,': [75, 1842], 'generation': [78, 4066], 'five': [80], 'chiral': [81], 'centers': [82], 'an': [84, 247, 1036, 1364, 2823, 3473, 4357], 'achiral': [85], 'substrate.': [86], 'The': [87, 126, 151, 333, 361, 618, 807, 1095, 1208, 1339, 1551, 1889, 1946, 2022, 2136, 2344, 2425, 2492, 2591, 2713, 3506, 3663, 3687, 3818, 3920, 3969, 4016, 4030, 4327], 'mechanism': [88, 132, 599, 3815, 4018, 4401], 'biosynthesis': [91, 1443, 1470, 1473, 1485], 'outlined': [93], '1967': [95], 'Hamberg': [97], 'Samuelsson': [99, 102, 205, 1689, 1776], '(2Hamberg': [100], 'M.': [101, 204, 1594, 1684, 1771, 1911, 2220, 2241, 2303, 2374, 2643, 2805, 3090, 3720, 3725, 3728, 3740, 4447], 'B.': [103, 206, 1690, 1777, 2476, 3737, 4456], 'J.': [104, 421, 468, 488, 698, 751, 769, 791, 849, 851, 928, 987, 1017, 1196, 1245, 1506, 1686, 1773, 1918, 2010, 2225, 2246, 2310, 2340, 2383, 2484, 2486, 2639, 2788, 2812, 2872, 2927, 2929, 3097, 3123, 3218, 3220, 3274, 3534, 3560, 3584, 3622, 3951, 3953, 4142, 4144, 4268], 'Biol.': [105, 260, 422, 469, 489, 752, 770, 792, 858, 929, 988, 1018, 1197, 1919, 2011, 2226, 2247, 2311, 2341, 2384, 2487, 2537, 2579, 2789, 2936, 3039, 3098, 3124, 3227, 3275, 3535, 3561, 3585, 3623, 3960], 'Chem.': [106, 423, 470, 490, 753, 771, 793, 930, 989, 1019, 1056, 1141, 1198, 1920, 2012, 2227, 2248, 2312, 2342, 2385, 2488, 2536, 2566, 2578, 2790, 2874, 3099, 3125, 3276, 3536, 3562, 3586, 3624], '1967;': [107], '242:': [108], '5336-5343Abstract': [109], 'Full': [110, 427, 474, 494, 757, 775, 797, 799, 934, 993, 995, 1023, 1025, 1202, 1924, 1926, 2016, 2231, 2233, 2252, 2254, 2316, 2318, 2389, 2583, 2794, 3103, 3105, 3129, 3131, 3280, 3282, 3540, 3542, 3566, 3568, 3590, 3592, 3628, 3630], 'Text': [111, 428, 475, 495, 758, 776, 798, 800, 935, 994, 996, 1024, 1026, 1203, 1925, 1927, 2017, 2232, 2234, 2253, 2255, 2317, 2319, 2390, 2584, 2795, 3104, 3106, 3130, 3132, 3281, 3283, 3541, 3543, 3567, 3569, 3591, 3593, 3629, 3631], 'PDF': [112, 429, 476, 496, 759, 777, 801, 936, 997, 1027, 1204, 1928, 2018, 2235, 2256, 2320, 2391, 2585, 2796, 3107, 3133, 3284, 3544, 3570, 3594, 3632], 'PubMed': [113, 217, 232, 264, 430, 453, 477, 497, 554, 580, 703, 760, 778, 802, 839, 862, 895, 937, 998, 1028, 1061, 1090, 1146, 1163, 1205, 1250, 1334, 1414, 1511, 1601, 1616, 1663, 1678, 1701, 1765, 1788, 1929, 2019, 2236, 2257, 2321, 2392, 2411, 2541, 2586, 2660, 2752, 2797, 2817, 2856, 2878, 2917, 2940, 2973, 3026, 3043, 3060, 3108, 3134, 3192, 3231, 3285, 3405, 3449, 3545, 3571, 3595, 3633, 3964, 4082, 4151, 4203, 4272], 'Scholar),': [115, 1933, 4207], 'basic': [118], 'tenets': [119], 'have': [120, 606, 1869, 2519, 2901, 4177, 4233, 4314], 'been': [121, 344, 503, 720, 1346, 1566, 2520, 2521, 2902, 4178, 4315], 'confirmed': [122, 194, 345, 2445], 'subsequent': [124], 'studies.': [125], 'key': [127], 'step': [128, 1709, 2631, 2667], 'proposed': [131], 'formation': [135, 276, 964, 1431], 'bicyclic': [137], 'peroxides': [138, 1175], '(endoperoxides)': [139], 'as': [140, 309, 338, 1549, 3768, 3775, 4169, 4175, 4298], 'initial': [142], 'products': [143], 'acid': [147, 594, 628, 687, 736, 826, 913, 1268, 1392, 1651, 1715, 1951, 2042, 2106, 2201, 2368, 2372, 2460, 3991, 4391], 'oxygenation': [148, 688, 1716], '(Fig.': [149, 600, 3180, 3942], '1).': [150, 601], 'term': [152, 156], '(COX)1': [154], '2The': [155], 'is': [158, 246, 379, 655, 711, 818, 904, 916, 1045, 1067, 1097, 1104, 1216, 1230, 1290, 1363, 1420, 1449, 1575, 1717, 1803, 2037, 2064, 2089, 2098, 2293, 2350, 2359, 2418, 2598, 2626, 2685, 2716, 2726, 2761, 2767, 3140, 3321, 3341, 3465, 3510, 3605, 3671, 3703, 3761, 3766, 3897, 4014, 4038, 4044, 4095, 4108, 4130, 4224, 4280, 4318, 4384, 4408], 'used': [159], 'to': [160, 166, 168, 179, 239, 287, 605, 613, 615, 679, 821, 962, 1125, 1181, 1543, 1545, 1561, 1743, 1825, 1858, 1880, 1894, 1968, 1994, 2028, 2056, 2073, 2075, 2084, 2296, 2365, 2369, 2420, 2511, 2616, 2676, 2689, 2700, 2763, 3073, 3081, 3211, 3299, 3324, 3333, 3413, 3494, 3512, 3607, 3655, 3828, 3834, 3977, 3988, 3999, 4069, 4414, 4443, 4455], 'describe': [161, 180], 'enzyme': [163, 182, 386, 943, 1102, 1308, 1375, 1817, 2299], 'activity': [164, 174, 290, 300, 1304], 'refer': [167], 'active': [170, 907, 1875, 1963, 2050, 2137, 2435, 3163, 3246, 3685, 3717, 3785, 3932], 'site': [171, 1876, 1964, 1984, 2051, 2138, 2436, 3164, 3786, 3933], 'on': [175, 1218, 1811, 2099, 3673, 4049, 4162], 'protein.was': [177], 'coined': [178], 'carried': [184], 'out': [185, 2422], 'this': [186, 1288, 2062, 2159, 2423, 2453, 3199, 3497, 4010, 4236, 4348, 4354], 'chemical': [188, 1813], 'transformation,': [189, 244], 'its': [191, 376, 1430, 3801], 'role': [192, 652, 1453, 1900], 'isolation': [197], 'endoperoxides': [200], '1973': [202], '(3Hamberg': [203], 'Proc.': [207, 443, 544, 1404, 1691, 1778, 2650, 2742], 'Natl.': [208, 444, 545, 1405, 1692, 1779, 2651, 2743], 'Acad.': [209, 445, 546, 1406, 1693, 1780, 2652, 2744], 'Sci.': [210, 446, 547, 1407, 1694, 1781, 2653, 2745], 'U.': [211, 447, 548, 1408, 1695, 1782, 2654, 2746], 'S.': [212, 448, 549, 568, 1409, 1696, 1783, 2473, 2641, 2647, 2655, 2747, 3722, 3866, 4191], 'A.': [213, 418, 449, 550, 847, 1329, 1410, 1697, 1784, 2330, 2656, 2748, 2925, 3216, 3949], '1973;': [214, 229, 1660, 1762], '70:': [215], '899-903Crossref': [216], 'Scopus': [218, 233, 265, 454, 555, 581, 704, 803, 840, 863, 896, 999, 1029, 1062, 1091, 1147, 1164, 1251, 1335, 1415, 1512, 1602, 1617, 1664, 1679, 1702, 1766, 1789, 1930, 2237, 2258, 2322, 2412, 2542, 2555, 2570, 2587, 2661, 2753, 2818, 2857, 2879, 2918, 2941, 2974, 3027, 3044, 3061, 3109, 3135, 3193, 3232, 3286, 3406, 3450, 3546, 3572, 3596, 3634, 3965, 4083, 4152, 4204, 4273], '(570)': [219], 'Scholar,': [221, 432, 457, 479, 558, 762, 780, 843, 866, 1002, 1150, 1605, 1667, 1682, 1769, 2394, 2545, 2558, 2573, 2799, 2860, 2921, 2944, 3030, 3047, 3112, 3549, 3575], '4Nugteren': [222], 'D.H.': [223, 1654, 1756, 2807], 'Hazelhof': [224, 1655, 1757], 'E.': [225, 1656, 1758, 3551, 3613, 3870], 'Biochim.': [226, 1657, 1759], 'Biophys.': [227, 1658, 1760], 'Acta.': [228, 1659, 1761], '326:': [230, 1661, 1763], '448-461Crossref': [231, 1662, 1764], '(635)': [234, 1665, 1767], 'In': [237, 3236, 4277], 'addition': [238], 'catalyzing': [240], 'fascinating': [242], 'metabolic': [243], 'COX': [245, 591, 603, 654, 714, 1066, 1173, 1229, 1262, 1371, 1795, 2729, 3245, 3305, 3931, 4230, 4375], 'enormously': [248], 'important': [249, 1523, 4359, 4421], 'pharmacological': [250, 4432], 'target.': [251], 'Vane': [252], 'reported': [253, 1351], '1971': [255], '(5Vane': [256], 'J.R.': [257], 'Nat.': [258, 856, 2934, 3037, 3225, 3958], '1971;': [261], '231:': [262], '232-235Crossref': [263], '(7348)': [266], 'Scholar)': [268, 1254, 3409], '(NSAIDs)': [273], 'inhibit': [274, 1388, 1441, 2455, 4405], 'demonstrated': [278, 1255], 'relative': [281], 'inhibitory': [282], 'potency': [283], 'vitro': [285], 'correlates': [286], 'vivo': [292, 1490], '.': [293], 'This': [294, 500, 1741, 1974, 2087, 2114, 2665], 'not': [295, 905, 910, 2206, 2351, 2462, 2717, 3339, 3466, 3518, 3767, 3898, 3911, 4351, 4385, 4409, 4417], 'only': [296, 2728, 2838, 4418], 'explained': [297], 'beneficial': [299, 395], 'NSAIDs': [302, 398, 527, 2980, 3086, 3521, 3836], 'also': [304, 2990, 4425], 'side': [306, 404, 2102, 3457, 3498, 3651, 3681, 3843], 'effects': [307, 396, 405], 'such': [308, 1212, 1548, 1883], 'gastrointestinal': [310], 'toxicity': [311, 521], 'bleeding': [313, 4220], 'because': [314, 1527, 3468], 'prostaglandins': [315], 'related': [317], 'molecules': [318, 337, 2067], '(i.e.': [319], 'thromboxane)': [320], 'are': [321, 513, 629, 1533, 1538, 2140, 2155, 2524, 3997, 4058, 4160, 4168, 4337, 4441], 'involved': [322], 'very': [325], 'broad': [326], 'range': [327, 4242, 4285, 4436], 'physiological': [329, 4244], 'pathophysiological': [331, 4246], 'responses.': [332], 'importance': [334, 2426, 4004], 'these': [336, 2348, 3347, 3994, 4106, 4415], 'autocrine': [339], 'paracrine': [341], 'mediators': [342], 'has': [343, 502, 719, 1345, 1350, 1565, 4350], 'recently': [346, 2444, 4317], 'phenotypes': [349], 'mice': [351, 4232], 'bearing': [352], 'targeted': [353], 'deletions': [354], 'inCOX': [355], 'genes': [356, 1536, 4376], 'receptor': [359], 'genes.': [360], 'discovery': [362], 'second': [365, 1847, 2630], '(COX-2': [367], ')': [368, 3945], 'coding': [369], 'demonstration': [374, 508], 'product': [378, 1356], 'distributed': [380], 'differently': [381], 'originally': [384], '(COX-1)': [387], 'raised': [388], 'possibility': [390], 'some': [392, 1256], 'may': [399, 1475, 1520, 2703, 3297, 3653, 3787, 4426], 'be': [400, 680, 1521, 1562, 1887, 2045, 2128, 2617, 4070, 4114], 'separable': [401], 'development': [407], 'isoform-selective': [409], 'inhibitors': [410, 512, 1482, 1907, 2597, 2603, 2621, 2900, 3260, 3909, 4159, 4228, 4290], '(6Fu': [411], 'J.-Y.': [412], 'Masferrer': [413, 1497], 'J.L.': [414, 529, 1498, 3848], 'Seibert': [415, 542, 885, 1499, 2848, 2963, 3016, 3395, 3439, 3532, 3857], 'K.': [416, 543, 886, 1500, 2849, 2964, 3017, 3396, 3440, 3533, 3858], 'Raz': [417], 'Needleman': [419, 1503], 'P.': [420, 1504, 2560, 3733, 3738, 3744, 4467], '1990;': [424, 931, 1160, 2013, 2791], '265:': [425, 932, 2014, 2792], '16737-16740Abstract': [426], '7Xie': [433], 'W.': [434, 694, 1241, 2337, 3742, 3746, 4459], 'Chipman': [435], 'J.G.': [436], 'Robertson': [437], 'D.L.': [438, 442, 925, 1997, 2222, 2380, 2775], 'Erikson': [439], 'R.L.': [440, 2007, 2785], 'Simmons': [441], '1991;': [450, 471, 491], '88:': [451], '2692-2696Crossref': [452], '(1686)': [455], '8Kujubu': [458], 'D.A.': [459, 487, 2216, 2810], 'Fletcher': [460], 'B.S.': [461, 531], 'Varnum': [462], 'B.C.': [463, 1010, 1397, 2843, 2866], 'Lim': [464], 'R.W.': [465], 'Herschman': [466], 'H.R.': [467], '266:': [472, 492], '12866-12872Abstract': [473], "9O'Banion": [480], 'M.K.': [481], 'Sadowski': [482], 'H.B.': [483, 1193, 1596], 'Winn': [484], 'V.': [485], 'Young': [486], '23261-23267Abstract': [493], 'hypothesis': [501, 589, 1289, 3345], 'dramatically': [504, 1539], 'validated': [505], 'selective': [510, 2503, 2899, 3917, 4157, 4227], 'COX-2': [511, 814, 1532, 2171, 2194, 2286, 2364, 2504, 2773, 2835, 2894, 3337, 3373, 3489, 3507, 3691, 3716, 3802, 3808, 3896, 3918, 3983, 4013, 4158, 4289, 4406], 'analgesic': [516], 'lack': [518], 'gastric': [520], 'associated': [522, 2718], 'with': [523, 823, 918, 944, 1174, 1263, 1318, 1451, 1839, 1845, 1851, 1861, 2091, 2150, 2187, 2263, 2465, 2719, 2895, 2898, 2983, 2993, 3146, 3343, 3693, 3709, 3763, 3895, 4477], 'all': [524, 1862, 3304, 3805], 'currently': [525], 'available': [526, 4319], '(10Masferrer': [528], 'Zweifel': [530], 'Manning': [532], 'P.T.': [533], 'Hauser': [534, 3526], 'S.D.': [535, 3527], 'Leahy': [536], 'K.M.': [537], 'Smith': [538, 926, 1916, 2008, 2223, 2308, 2381, 2786, 3095, 4460], 'W.G.': [539], 'Isakson': [540, 571, 887, 2965, 3018, 3397, 3441, 3859, 4194, 4468], 'P.C.': [541, 572, 888, 2966, 3019, 3398, 3442, 3860, 4195], '1994;': [551, 836, 1087, 1598, 2386, 2657, 2914, 3189], '91:': [552, 2658], '3228-3232Crossref': [553], '(1290)': [556], '11Simon': [559], 'L.S.': [560, 4183, 4260], 'Lanza': [561, 4184], 'F.L.': [562, 4185], 'Lipsky': [563, 4186, 4265], 'P.E.': [564, 4187, 4266], 'Hubbard': [565, 4188], 'R.C.': [566, 4189], 'Talwalker': [567, 4190], 'Schwartz': [569, 4192], 'B.D.': [570, 4193], 'Geis': [573, 4196], 'G.S.': [574, 4197], 'Arthritis': [575, 4198], 'Rheum.': [576, 4199], '1998;': [577, 794, 1020, 1058, 1143, 2538, 2853, 2875, 3277, 4148, 4200, 4269], '41:': [578, 2876, 4201], '1591-1602Crossref': [579, 4202], '(490)': [582, 4205], 'Substantial': [585], 'evidence': [586], 'supports': [587], 'oxygenates': [592], 'arachidonic': [593, 627, 686, 735, 912, 1284, 1650, 1714, 1806, 2200, 2367, 2459, 4390], 'free': [597, 4027], 'radical': [598, 677, 710, 959, 1282, 1574, 1642, 1722, 1732, 2082, 4028, 4065], 'Thus,': [602, 649, 1706], 'appears': [604, 678, 2172], 'co-opted': [607], 'process': [609], 'gives': [611], 'rise': [612], 'isoprostanes': [614], 'generate': [616], 'prostaglandins.': [617], 'major': [619, 4212], 'differences': [620, 2162, 2349], 'between': [621, 1468, 2167, 2355, 3488], 'COX-catalyzed': [622], 'spontaneous': [624], 'oxidation': [625, 1214, 1260, 1652, 2457, 4037], 'increased': [631], 'rate': [632], 'high': [634], 'degree': [635], 'stereochemical': [637], 'control': [638, 664], 'enzymatic': [641], 'reaction': [642, 1317, 1838, 1844, 1856], '(1': [643], '64': [645], 'possible': [646], 'isomers': [647], 'predominates).': [648], 'overall': [651], 'rather': [656, 3678, 3837], 'simple:': [657], 'stereospecifically': [658], 'remove': [659], '13-pro-S': [661, 1834, 1936, 2096], '-hydrogen': [662], 'stereochemistry': [666], 'oxygenation.': [668], 'How': [669, 1793], 'does': [670, 909, 1794, 2205, 3910], 'do': [672], 'this?': [673], 'A': [674, 708, 3358, 3454, 4087], 'tyrosyl': [676, 709, 958, 1274, 1281, 1641, 4064], 'oxidizing': [682, 734, 1109, 1233], 'agent': [683], 'initiates': [685], '(12Karthein': [689], 'Dietz': [691], 'Nastainczyk': [693, 1240], 'Ruf': [695, 1235, 1242], 'H.H.': [696, 1243], 'Eur.': [697, 1244, 2811], 'Biochem.': [699, 1246, 2813], '1988;': [700, 1247], '171:': [701, 1248], '313-320Crossref': [702], '(231)': [705], 'formed': [712], 'during': [713], 'turnover,': [715], 'although': [717, 4347], 'there': [718, 4043, 4057], 'debate': [721, 1569, 1632], 'over': [722, 4293], 'identity': [724, 1340, 1552], 'spectroscopically': [727, 1272], 'detected': [728], 'radicals,': [729], 'appear': [731, 2615], 'capable': [732, 1231], '(13DeGray': [737], 'J.A.': [738, 3114, 3559, 3621], 'Lassmann': [739], 'G.': [740, 766, 784, 786, 1158, 1671, 2396, 2400, 3732], 'Curtis': [741, 977], 'J.F.': [742, 978], 'Kennedy': [743], 'T.A.': [744], 'Marnett': [745, 981, 1015, 1194, 1326, 1402, 2850, 2870, 3867, 4145], 'L.J.': [746, 982, 1016, 1195, 1327, 1403, 2531, 2851, 2871, 3868, 4146], 'Eling': [747, 983, 1011, 1322], 'T.E.': [748, 984, 1012, 1323], 'Mason': [749, 985, 1013], 'R.P.': [750, 986, 1014], '1992;': [754, 772, 1331], '267:': [755, 773], '23583-23588Abstract': [756], '14Tsai': [763], 'A.-L.': [764, 782, 1156, 1611, 1669, 2398], 'Palmer': [765, 783, 1157, 2399], 'Kulmacz': [767, 789, 922, 1324, 1608, 1672, 2405, 3582], 'R.J.': [768, 790, 923, 1152, 1325, 1609, 1673, 2406, 3583], '17753-17759Abstract': [774], '15Tsai': [781], 'Xiao': [785], 'Swinney': [787, 3272], 'D.C.': [788, 1004, 3273], '273:': [795, 1021, 3278], '3888-3894Abstract': [796], '(81)': [804], 'crystal': [808], 'structures': [809, 2139, 2884, 3348, 3806, 4287], 'both': [811, 2111], 'COX-1': [812, 1879, 1995, 2177, 2204, 2271, 2417, 2771, 3072, 3340, 3464, 3491, 3602, 3760, 3784, 4000], 'reveal': [815, 3349], 'Tyr-385': [817, 1110, 1573, 1731], 'positioned': [819, 1892], 'perfectly': [820], 'react': [822], 'substrate': [827, 2043, 2164], '(Fig.2)': [828], '(16Picot': [829, 1080, 2907, 3182], 'D.': [830, 880, 1081, 1494, 2243, 2562, 2645, 2908, 2958, 3011, 3034, 3051, 3116, 3183, 3390, 3434, 3557, 3619, 3726, 3749], 'Loll': [831, 1082, 2909, 3184], 'P.J.': [832, 1083, 2404, 2910, 3032, 3049, 3120, 3185], 'Garavito': [833, 1084, 1914, 2306, 2911, 3035, 3054, 3093, 3186], 'R.M.': [834, 1085, 1915, 2307, 2912, 3036, 3055, 3094, 3187], 'Nature.': [835, 891, 1086, 2913, 2969, 3022, 3188, 3401, 3445], '367:': [837, 1088, 2915, 3190], '243-249Crossref': [838, 1089, 2916, 3191], '(1151)': [841, 1092, 2919, 3194], '17Luong': [844, 2922], 'C.': [845, 853, 1607, 2327, 2378, 2479, 2847, 2923, 2931, 3214, 3222, 3553, 3615, 3730, 3747, 3947, 3955], 'Miller': [846, 2924, 3215, 3948], 'Barnett': [848, 2926, 3217, 3950], 'Chow': [850, 2928, 3219, 3952], 'Ramesha': [852, 2244, 2930, 3221, 3954], 'Browner': [854, 2932, 3223, 3956, 4448], 'M.F.': [855, 2933, 3224, 3957], 'Struct.': [857, 2935, 3038, 3226, 3959], '1996;': [859, 892, 1411, 1921, 2313, 2937, 2970, 3023, 3057, 3100, 3228, 3402, 3446, 3537, 3587, 3961], '3:': [860, 2938, 3229, 3962], '927-933Crossref': [861, 2939, 3230, 3963], '(561)': [864, 2942, 3233, 3966], '18Kurumbail': [867, 2945], 'R.G.': [868, 2946, 2999, 3378, 3422], 'Stevens': [869, 2947, 3000, 3379, 3423, 3849], 'A.M.': [870, 1189, 2948, 3001, 3380, 3424, 3850], 'Gierse': [871, 979, 2949, 3002, 3381, 3425, 3853], 'J.K.': [872, 980, 2950, 3003, 3382, 3426, 3523, 3854], 'McDonald': [873, 2951, 3004, 3383, 3427, 3524], 'J.J.': [874, 2547, 2952, 3005, 3384, 3428, 3525], 'Stegeman': [875, 2953, 3006, 3385, 3429], 'R.A.': [876, 2635, 2954, 3007, 3386, 3430, 3852, 4075, 4258], 'Pak': [877, 2955, 3008, 3387, 3431], 'J.Y.': [878, 2956, 3009, 3388, 3432], 'Gildehaus': [879, 2957, 3010, 3389, 3433], 'Miyashiro': [881, 2959, 3012, 3391, 3435], 'J.M.': [882, 2637, 2649, 2960, 3013, 3392, 3436], 'Penning': [883, 2961, 3014, 3393, 3437, 4076], 'T.D.': [884, 2962, 3015, 3394, 3438], 'Stallings': [889, 2967, 3020, 3399, 3443, 3861], 'W.C.': [890, 2402, 2968, 3021, 3400, 3444, 3862], '384:': [893, 2971, 3024, 3403, 3447], '644-648Crossref': [894, 2972, 3025, 3404, 3448], '(1600)': [897, 2975, 3028, 3407, 3451], 'Indeed,': [900], 'Y385F': [902], 'mutant': [903, 2269, 2284, 3508, 3603], 'catalytically': [906], 'oxidize': [911], 'when': [914], 'treated': [917], 'peroxide': [919], '(19Shimokawa': [920], 'T.': [921, 1688, 1775], 'DeWitt': [924, 2221, 2379], 'W.L.': [927, 1321, 1917, 2009, 2224, 2309, 2382, 2787, 3096], '20073-20076Abstract': [933], 'Incubation': [940], 'wild-type': [942, 2298], 'arachidonate': [945, 1820, 1871, 1903, 1977, 1992, 2280, 2291, 2442, 2997, 4036], 'presence': [948, 1379, 3471], 'nitric': [950, 1358], 'oxide': [951, 1359], 'quenches': [952], 'EPR': [954], 'signal': [955], 'leads': [961, 1742, 1967], 'nitrotyrosine': [966], 'at': [967, 1577, 1627, 1643, 1957, 2430, 2452, 2469, 2495, 2904, 3169, 3478, 3675, 3711, 3779, 3926, 4320], 'position': [968, 2454, 3479], '385': [969], '(20Gunther': [973], 'M.R.': [974], 'Hsi': [975, 1007], 'L.C.': [976], '1997;': [990, 1675, 2249, 2408, 2552, 2567, 3563, 3625, 4079], '272:': [991, 2250, 3564, 3626], '17086-17090Abstract': [992], '(163)': [1000], '21Goodwin': [1003], 'Gunther': [1005], 'M.H.': [1006], 'L.H.': [1008, 3579], 'Crews': [1009, 1396, 2842, 2865], '8903-8909Abstract': [1022], '(131)': [1030], 'Protein': [1033], 'radicals': [1034, 4034], 'require': [1035], 'oxidant': [1037, 1366], 'formation,': [1040], 'which': [1041, 1425, 1448, 1728, 1896, 2623, 2682, 2760, 2989, 3150, 3175, 3248, 3318, 3481, 3765, 4312, 4403], 'most': [1043, 1133, 2592, 2723], 'cases': [1044], 'metal-containing': [1047], 'prosthetic': [1048], 'group': [1049, 2986, 3702, 3774, 3825], '(22Stubbe': [1050, 1135], 'van': [1052, 1137, 3705], 'der': [1053, 1138, 3706], 'Donk': [1054, 1139], 'W.A.': [1055, 1140], 'Rev.': [1057, 1142], '98:': [1059, 1144], '705-762Crossref': [1060, 1145], '(1364)': [1063, 1148], 'homodimer': [1069], '70-kDa': [1071], 'subunits': [1072], 'each': [1074, 1581, 1647, 1711], 'contain': [1075], 'one': [1076], 'molecule': [1077, 2825], 'heme': [1079, 1171, 1186, 1369], 'iron': [1096], 'ferric': [1098], 'resting': [1101], 'likely': [1105, 4281], 'thermodynamically': [1106], 'incapable': [1107], '(E': [1111, 2673, 2678, 3314], '12': [1112, 1122], '=': [1113, 1123], '0.9': [1114], 'V': [1115, 1127, 1223], 'Tyr⋅': [1117], '→': [1118, 1130], 'Tyr': [1119], 'E': [1121, 2695], '−0.2': [1124], '+0.2': [1126], 'Fe3+': [1129], 'Fe2+': [1131], 'hemes)': [1134], '23Kulmacz': [1151], 'Ren': [1153], 'Y.': [1154, 3752], 'Tsai': [1155, 1328, 1610, 2397], 'Biochemistry.': [1159, 1330, 1597, 1612, 1674, 2407, 3056, 4078, 4147], '29:': [1161], '8760-8771Crossref': [1162], '(84)': [1165], 'Reaction': [1168], 'generates': [1176, 1270, 4054], 'ferryl-oxo': [1178], 'analogous': [1180], 'compound': [1182, 1226], 'I': [1183, 1227], 'classic': [1185], 'peroxidases': [1187], '(24Lambeir': [1188], 'Markey': [1190], 'C.M.': [1191, 3531, 3856], 'Dunford': [1192, 1595], '1985;': [1199], '260:': [1200], '14894-14896Abstract': [1201], 'redox': [1209], 'potential': [1210, 4226], 'higher': [1213, 2189], 'states': [1215], 'typically': [1217], 'order': [1220], '+1': [1222], 'so': [1224], 'Tyr-385.': [1234, 1945], 'co-workers': [1237], '(25Dietz': [1238], '321-328Crossref': [1249], '(197)': [1252], 'time': [1257, 3301, 3657], 'ago': [1258], 'organic': [1264], 'hydroperoxides': [1265, 1269, 1393], 'detectable': [1273], 'radical,': [1275], 'postulated': [1278], 'oxidizes': [1283, 2181, 2195], 'acid.': [1285], 'Support': [1286], 'provided': [1291], 'existence': [1294, 4372], 'significant': [1296], 'lag': [1297], 'phases': [1298], 'induction': [1301, 2706], 'Mn-protoporphyrin': [1306], 'IX-reconstituted': [1307], 'site-directed': [1310], 'mutants': [1311], 'exhibit': [1313], 'diminished': [1314], 'rates': [1315], 'hydroperoxide': [1319, 1343], '(26Smith': [1320], '31:': [1332], '3-7Crossref': [1333], '(132)': [1336], 'activator': [1344, 1556], 'uncertain.': [1347, 4015], 'Our': [1348], 'laboratory': [1349], 'peroxynitrite,': [1353], 'coupling': [1355], 'superoxide': [1361, 1423, 1437], 'anion,': [1362], 'excellent': [1365], 'activates': [1373], 'even': [1376], 'glutathione': [1383, 1386], 'peroxidase': [1384, 1590, 4024], 'activation': [1389, 1458, 1517, 1747], '(27Landino': [1394], 'L.M.': [1395], 'Timmons': [1398], 'M.D.': [1399], 'Morrow': [1400], 'J.D.': [1401], '93:': [1412], '15069-15074Crossref': [1413], '(398)': [1416], 'Activation': [1419], 'inhibited': [1421], 'dismutase,': [1424], 'scavenges': [1426], 'peroxynitrite': [1427, 1455], 'prevents': [1429], 'NO': [1433, 1469, 1480, 1529], 'O⨪2.': [1435], 'Lipophilic': [1436], 'dismutase': [1438], 'mimetic': [1439], 'agents': [1440], 'cultured': [1445], 'mouse': [1446, 2134, 2890], 'macrophages,': [1447], 'consistent': [1450, 2090, 3342], 'intact': [1460], 'cells.': [1461], 'These': [1462], 'findings': [1463], 'provide': [1464, 3811, 3912, 4420], 'biochemical': [1466], 'link': [1467], 'explain': [1476], 'finding': [1478], 'synthase': [1481, 1530], 'reduce': [1483, 3788], 'inflammatory': [1487, 1546], 'lesions': [1488], '(Equation': [1491, 2632], '1)': [1492], '(28Salvemini': [1493], 'Settle': [1495], 'S.L.': [1496], 'Currie': [1501], 'M.G.': [1502], 'Br.': [1505], 'Pharmacol.': [1507], '1995;': [1508, 1613, 2228, 2580, 3040, 3126], '114:': [1509], '1171-1178Crossref': [1510], '(251)': [1513], 'Peroxynitrite': [1516], 'especially': [1522, 3330, 4115], 'activated': [1525], 'macrophages': [1526], 'inducible': [1528], 'immediate': [1534], 'early': [1535], 'expressed': [1540, 4378], 'response': [1542], 'exposure': [1544], 'stimuli': [1547], 'lipopolysaccharide.': [1550], 'non-inflammatory': [1558], 'cells': [1559], 'remains': [1560, 4356, 4396], 'determined.': [1563], 'There': [1564], 'considerable': [1567], 'experimental': [1568], 'about': [1570], 'whether': [1571, 1882], 'regenerated': [1576], 'end': [1579, 1645, 1975, 2497], 'catalytic': [1583, 1591, 1640], 'cycle': [1584, 1592, 1648], 'requires': [1586], 'reoxidation': [1587], 'another': [1589], '(29Bakovic': [1593], '33:': [1599], '6475-6482Crossref': [1600], '(37)': [1603], '30Wei': [1606], '34:': [1614], '8499-8512Crossref': [1615], '(49)': [1618], 'Detailed': [1621], 'kinetic': [1622], 'investigations': [1623], 'confirm': [1624], 'observations': [1625], 'extant': [1626], 'onset': [1629], 'strongly': [1634], 'support': [1635], 'regeneration': [1637], '(4Nugteren': [1653, 1755], '31Tsai': [1668], 'Wu': [1670], '36:': [1676, 2409, 4080], '13085-13094Crossref': [1677], '(23)': [1680], '32Hamberg': [1683, 1770], 'Svensson': [1685, 1772], 'Wakabayashi': [1687, 1774], '1974;': [1698, 1785], '71:': [1699, 1786], '345-349Crossref': [1700, 1787], '(872)': [1703, 1790], 'final': [1708, 2031], 'round': [1712, 1736], 'reduction': [1718], 'peroxyl': [1721], 'precursor': [1723], 'PGG2': [1725, 1754, 1802, 1860], 'Tyr-385,': [1727], 'regenerates': [1729], 'next': [1735, 4295], 'catalysis': [1739], '(Fig.1).': [1740], 'multiple': [1744], 'turnovers': [1745], 'per': [1746], 'event': [1748], 'allows': [1750], 'accumulation': [1752], 'ensure': [1796], 'single': [1799], 'stereoisomer': [1800], 'produced': [1804], 'acid?': [1807], 'One': [1808, 2059], 'can': [1809, 1886, 2044, 2127], 'predict': [1810], 'purely': [1812], 'grounds': [1814], 'must': [1818], 'bind': [1819, 3332], 'conformation': [1823, 1885, 2032, 2054], 'similar': [1824, 2125, 2142, 2295, 3455, 3833, 3987], 'illustrated': [1827], 'Fig.': [1829, 3356], '1.': [1830], 'Removal': [1831], 'hydrogen': [1835, 1937, 2097, 3411, 3975], 'followed': [1836], 'O2,': [1840], 'serial': [1841], 'O2': [1848, 2066], 'could': [1849], 'occur': [1850, 3212], 'minimal': [1852], 'motion': [1853], 'intermediates': [1857, 2083], 'produce': [1859], 'correct': [1864], 'stereocenters.': [1865], 'We': [1866, 4440], 'others': [1868], 'docked': [1870], 'into': [1872, 1954, 3367, 3649, 3813, 3840, 3936], 'sheep': [1878, 2121, 2888], 'test': [1881], 'accommodated.': [1888], 'carboxylate': [1890, 2995], 'adjacent': [1893], 'Arg-120,': [1895, 2764, 2988, 3978], 'plays': [1897], 'crucial': [1899], 'binding': [1902, 1993, 2438, 2620, 3208, 4129], 'arylalkanoic': [1905, 3259, 3519, 3990], 'acid-type': [1906, 3520], '(33Bhattacharyya': [1908, 2300, 3087], 'D.K.': [1909, 2210, 2301, 3088], 'Lecomte': [1910, 2302, 3089], 'Rieke': [1912, 2304, 3091], 'C.J.': [1913, 2305, 3092], '271:': [1922, 2314, 3101, 3538, 3588], '2179-2184Abstract': [1923, 2315, 3102], '(170)': [1931, 2323, 3062, 3110], 'placed': [1939], 'near': [1940], 'phenolic': [1942], 'hydroxyl': [1943], 'ω-end': [1947, 2440], 'inserted': [1953], 'channel': [1956, 2072, 2429, 3462], 'top': [1959, 2432, 3677, 3781], 'eventually': [1966], 'surface': [1970], 'protein.': [1973], 'straddles': [1978], 'α-helix': [1980], 'containing': [1981], 'Ser-530,': [1982, 2759], 'acetylated': [1985], 'aspirin.': [1987], 'Acetylation': [1988], 'aspirin': [1990], 'blocks': [1991], '(34DeWitt': [1996, 2774], 'El-Harith': [1998, 2776], 'E.A.': [1999, 2777], 'Kraemer': [2000, 2778], 'S.A.': [2001, 2779], 'Andrews': [2002, 2780], 'M.J.': [2003, 2781], 'Yao': [2004, 2782], 'E.F.': [2005, 2783], 'Armstrong': [2006, 2784], '5192-5198Abstract': [2015, 2793], 'arachidonate-enzyme': [2023], 'then': [2026], 'minimized': [2027], 'obtain': [2029], 'displayed': [2033], 'Fig.3.': [2035], 'It': [2036, 2757], 'nicely': [2046], 'accommodated': [2047], 'within': [2048], 'expected': [2055], 'yield': [2057], 'PGG2.': [2058, 2086], 'prediction': [2060, 2088], 'model': [2063, 2115, 2126, 4137], 'diffuse': [2068], 'up': [2069], 'central': [2071], 'couple': [2074], 'solvent-exposed': [2077], 'sides': [2078], 'carbon': [2081, 2183], 'form': [2085], 'fact': [2093], 'opposite': [2101], 'direction': [2109], 'O2coupling': [2112], 'reactions.': [2113], 'developed': [2117, 2129, 2829], 'using': [2118, 2130], 'coordinates': [2119, 2132, 4451], 'COX-1,': [2122, 2889], 'COX-2.': [2135], 'quite': [2141, 2294], 'two': [2145, 2169, 2357, 4394], 'forms': [2146], 'enzyme,': [2149], 'few': [2152, 4296], 'exceptions': [2153], 'detailed': [2156], 'below.': [2157], 'Despite': [2158, 4365], 'similarity,': [2160], 'specificities': [2165], 'exist': [2166], 'enzymes.': [2170], 'much': [2173, 2188], 'more': [2174, 2687, 2768, 4131], 'accommodating': [2175], 'than': [2176, 2191, 2772, 3679, 3838, 4133], '18': [2182], 'efficiency': [2190], 'COX-1.': [2192], 'Also,': [2193], 'hydroxyethylamide': [2197], 'derivative': [2198], '(anandamide)': [2202], 'whereas': [2203, 2281], '(35Laneuville': [2207], 'O.': [2208, 2376, 3053], 'Breuer': [2209], 'Xu': [2211], 'N.': [2212, 2739], 'Huang': [2213], 'Z.H.': [2214], 'Gage': [2215], 'Watson': [2217], 'J.T.': [2218], 'Lagarde': [2219], '270:': [2229, 3127], '19330-19336Abstract': [2230], '(208)': [2238], 'Scholar,36Yu': [2240], 'Ives': [2242], 'C.S.': [2245], '21181-21186Abstract': [2251], '(350)': [2259], 'Consistent': [2262], 'latter': [2265], 'observation,': [2266], 'R120Q': [2268], 'demonstrates': [2272, 3359, 3821], '100-fold': [2274], 'increase': [2275], 'K': [2277], 'm': [2278, 2289], 'corresponding': [2283], 'displays': [2287], 'aK': [2288], '3Rieke,': [2326], 'J.,': [2328], 'Mulichak,': [2329], 'M.,': [2331, 2334], 'Garavito,': [2332], 'Smith,': [2336], 'L.': [2338, 2483, 3735, 4256], '(1999)': [2339, 2485], '274,17109–17114.': [2343], 'molecular': [2345, 3351, 4429], 'basis': [2346, 3352, 3665], 'understood.': [2352, 4110], 'Another': [2353], 'difference': [2354], 'enzymes': [2358, 4395], 'ability': [2361], 'aspirin-acetylated': [2363], 'oxygenate': [2366], '15-(R': [2370], ')-hydroxyeicosatetraenoic': [2371], '(37Lecomte': [2373], 'Laneuville': [2375], 'Ji': [2377], '269:': [2387], '13207-13215Abstract': [2388], '38Xiao': [2395], 'Boyar': [2401], 'Marshall': [2403], '1836-1845Crossref': [2410], '(111)': [2413], 'Acetylated': [2416], 'unable': [2419], 'carry': [2421], 'transformation.': [2424], 'mutagenesis': [2447, 3066, 4100], 'Gly-533.': [2449], 'Bulky': [2450], 'substitutions': [2451, 3502, 3674], 'three': [2466, 3995], 'less': [2467], 'carbons': [2468], 'ω-end.': [2471], '4Rowlinson,': [2472], 'W.,': [2474], 'Crews,': [2475], 'C.,': [2477], 'Lanzo,': [2478], 'A.,': [2480], 'Marnett,': [2482], ',': [2489], 'press.': [2491], 'anticipated': [2493], 'pot-of-gold': [2494], 'rainbow': [2500], 'awaiting': [2501], 'inhibitor': [2505, 2684, 2730, 3320, 3484, 3809, 3922, 3974, 4011], 'triggered': [2506], 'world': [2508], 'class': [2509, 2595], 'race': [2510], 'develop': [2512], 'candidate': [2513], 'drugs.': [2514], 'Some': [2515], 'efforts': [2518], 'successful': [2522], 'chronicled': [2525], 'several': [2527], 'recent': [2528, 4305], 'reviews': [2529], '(39Marnett': [2530], 'Kalgutkar': [2532], 'A.S.': [2533, 2841, 2862], 'Curr.': [2534], 'Opin.': [2535, 2549], '2:': [2539, 2581, 3041], '482-490Crossref': [2540], '(101)': [2543], '40Talley': [2546], 'Expert': [2548], 'Therapeutic': [2550], 'Patents.': [2551], '7:': [2553], '55-62Crossref': [2554], '(27)': [2556], '41Prasit': [2559], 'Riendeau': [2561, 3115, 3556, 3618], 'Annu.': [2563], 'Rep.': [2564], 'Med.': [2565, 2873], '32:': [2568], '211-220Crossref': [2569], '(96)': [2571], '42Munroe': [2574], 'D.G.': [2575], 'Lau': [2576], 'C.Y.': [2577], '343-350Abstract': [2582], '(29)': [2588], 'extensively': [2593], 'represented': [2594], 'diarylheterocycles;': [2599], 'other': [2600], 'classes': [2601], 'include': [2604, 3500], 'acidic': [2605], 'sulfonamides,': [2606], 'indomethacin': [2607, 3669, 3696, 3796], 'analogs,': [2608, 2610], 'zomepirac': [2609], 'di-t': [2612], '-butylphenols.': [2613], 'All': [2614], 'slow,': [2618], 'tight': [2619], 'selectivity': [2625, 2833, 3667, 4008], 'manifest': [2627], '2)': [2633], '(43Copeland': [2634], 'Williams': [2636], 'Giannaras': [2638], 'Nurnberg': [2640], 'Covington': [2642], 'Pinto': [2644], 'Pick': [2646], 'Trzaskos': [2648], '11202-11206Crossref': [2659], '(409)': [2662], 'slow': [2666], 'involves': [2668], 'conversion': [2670], '·I)': [2674], '*·I)': [2679, 3315], 'complex,': [2680], 'bound': [2686, 3322], 'tightly': [2688, 3323], 'enzyme.': [2691, 3326], 'Formation': [2692], '*·I': [2696], 'occurs': [2697], 'seconds': [2699], 'minutes': [2701], 'reflect': [2704, 3312], 'subtle': [2709], 'conformational': [2711], 'change.': [2712], 'time-dependent': [2714, 3513, 3608], 'change': [2715], 'covalent': [2720], 'modification': [2721], 'inhibitors.': [2724, 3306, 3992], 'Aspirin': [2725], 'covalently': [2732], 'modifies': [2733], '(44Roth': [2736], 'G.J.': [2737], 'Stanford': [2738], 'Majerus': [2740], 'P.W.': [2741], '1975;': [2749], '72:': [2750], '3073-3076Crossref': [2751], '(903)': [2754], 'acetylates': [2758, 2837], 'juxtaposed': [2762], 'potent': [2769], 'against': [2770, 4434], '45Van': [2800], 'Der': [2801], 'Ouderaa': [2802], 'F.J.': [2803], 'Buytenhek': [2804], 'Nugteren': [2806], 'Van': [2808, 4261], 'Dorp': [2809], '1980;': [2814], '109:': [2815], '1-8Crossref': [2816], '(135)': [2819, 3136], 'Recently,': [2822], 'aspirin-like': [2824], '(acetoxyphenylheptynyl': [2826], 'sulfide)': [2827], 'exhibits': [2831], '20-fold': [2832], 'Ser-530': [2839], '(46Kalgutkar': [2840], 'Rowlinson': [2844], 'S.W.': [2845], 'Garner': [2846], 'Science.': [2852], '280:': [2854], '1268-1270Crossref': [2855], '(269)': [2858], '47Kalgutkar': [2861], 'Kozak': [2863], 'K.R.': [2864], 'Hochgesang': [2867], 'Jr.,': [2868], 'G.P.': [2869, 3122], '4800-4818Crossref': [2877], '(120)': [2880], 'Crystal': [2883], 'complexes': [2886, 3310, 3810], 'COX-2,': [2891, 4002], 'non-selective': [2896], 'solved': [2903], '3–3.5-Å': [2905], 'resolution': [2906], 'Carboxylic': [2978], 'acid-containing': [2979, 3085], 'ion': [2981, 2991, 3826], 'pair': [2982], 'guanidinium': [2985], 'pairs': [2992, 3827], '(18Kurumbail': [2998, 3377, 3421], '48Loll': [3031], 'Picot': [3033, 3050], '637-642Crossref': [3042], '(468)': [3045], '49Loll': [3048], 'Ekabo': [3052], '35:': [3058], '7330-7340Crossref': [3059], 'Site-directed': [3065], 'arginine': [3069], 'residue': [3070], 'glutamine': [3074], 'glutamate': [3076], 'renders': [3077], 'resistant': [3080, 3511], 'inhibition': [3082, 3253, 3514, 3609, 3660], 'carboxylic': [3084], '50Mancini': [3113], 'Falgueyret': [3117], 'J.-P.': [3118], 'Vickers': [3119], "O'Neill": [3121], '29372-29377Abstract': [3128], 'Arg-120': [3139, 3829], 'part': [3141, 3159], 'hydrogen-bonding': [3144, 3200], 'network': [3145, 3201], 'Glu-524': [3147], 'Tyr-355,': [3149], 'stabilizes': [3151], 'substrate/inhibitor': [3152, 3207], 'interactions': [3153, 4094, 4107, 4120], 'closes': [3155], 'off': [3156, 3459], 'upper': [3158], 'spacious': [3167], 'opening': [3168], 'base': [3171], 'channel,': [3174], 'we': [3176], 'call': [3177], 'lobby': [3179, 3940], '4)': [3181], 'Disruption': [3197], 'opens': [3202], 'constriction': [3204, 3296, 3925], 'enables': [3206], 'release': [3210], '(17Luong': [3213, 3946], 'addition,': [3237, 4278], 'Tyr-355': [3238, 3981], 'sterically': [3239, 3482, 3938], 'hinders': [3240, 3483], 'mouth': [3242, 3928], 'site,': [3247], 'accounts': [3249], 'preferential': [3252], 'exhibited': [3254], 'byS': [3255], '-stereoisomers': [3256], 'α-methyl-substituted': [3258], '(e.g.': [3261], 'profens)': [3263], '(51So': [3264], 'O.-Y.': [3265], 'Scarafia': [3266], 'L.E.': [3267], 'Mak': [3268], 'A.Y.': [3269], 'Callan': [3270], 'O.H.': [3271], '5801-5807Abstract': [3279], '(88)': [3287], 'Opening': [3290], 'closing': [3292], 'Arg-120–Glu-524–Tyr-355': [3295], 'contribute': [3298, 3493, 3654], 'dependence': [3302, 3658], 'Structures': [3307], 'COX-inhibitor': [3309], 'presumably': [3311], 'That': [3327], 'COX-2-selective': [3328, 3908], 'inhibitors,': [3329], 'diarylheterocycles,': [3331], 'regions': [3334], 'accessible': [3335, 3467], 'selectivity.': [3355, 3803, 3817], '4': [3357, 3943], 'sulfonamide': [3362, 3645, 3824, 3970], 'moiety': [3363, 3648, 3971], 'SC-558': [3365], 'wedges': [3366], 'hydrophobic': [3369, 3456], '"side': [3370], 'pocket"': [3371], 'bordered': [3374], 'Val-523': [3376, 3640, 3842], 'bonds': [3412, 3976], 'Arg-513': [3414], 'peptide': [3417], 'bond': [3418], 'Phe-518': [3420], 'pocket': [3458, 3499, 3652, 3844], 'main': [3461], 'isoleucine': [3474], 'instead': [3475], 'valine': [3477], '523,': [3480], 'approach.': [3485], 'Other': [3486, 3873], 'changes': [3487], 'rigidification': [3495], 'R513H': [3503], 'V434I.': [3505], 'V523I': [3509], 'diarylheterocycles': [3516, 3611], '(52Gierse': [3522], 'Rangwala': [3528], 'S.H.': [3529], 'Koboldt': [3530], '15810-15814Abstract': [3539], '(389)': [3547], '53Wong': [3550], 'Bayly': [3552, 3614], 'Waterman': [3554, 3616], 'H.L.': [3555, 3617], 'Mancini': [3558, 3620], '9280-9286Abstract': [3565, 3627], '(130)': [3573, 3635], '54Guo': [3576], 'Q.P.': [3577], 'Wang': [3578], 'Ruan': [3580], 'K.H.': [3581], '19134-19139Abstract': [3589], '(118)': [3597], 'Conversely,': [3600], 'I523V': [3604], 'sensitive': [3606], '(53Wong': [3612], 'Movement': [3638], 'insertion': [3642], 'methylsulfone': [3647], 'diarylheterocycles.': [3662], 'structural': [3664], 'analogs': [3670], 'dependent': [3672], 'site.': [3686, 3718, 4326], 'structure': [3688], 'complexed': [3692], '4-bromobenzyl': [3695, 3701], 'analog': [3697], 'reveals': [3698], 'Waals': [3707], 'contact': [3708], 'Leu-503': [3710], 'apex': [3713], '5B.': [3719], 'McKeever,': [3721], 'Pandya,': [3724], 'Percival,': [3727], 'Ouellet,': [3729], 'Bayly,': [3731], "O'Neill,": [3734], 'Bastien,': [3736], 'Kennedy,': [3739], 'Adam,': [3741], 'Cromlish,': [3743], 'Roy,': [3745], 'Black,': [3748], 'Guay,': [3750], 'Leblanc,': [3753], 'submitted': [3754, 4464], 'publication.': [3756], 'Position': [3757], '503': [3758], 'substituted': [3762, 4334], 'phenylalanine,': [3764], 'easily': [3769], 'displaced': [3770], 'bromobenzyl': [3773], 'leucine.': [3776], 'Decreased': [3777], 'flexibility': [3778], 'affinity': [3790], 'analog,': [3797], 'thereby': [3798], 'accounting': [3799], 'Not': [3804], 'insights': [3812], 'NS-398·COX-2': [3819], 'manner': [3832, 3986], 'carboxylate-containing': [3835], 'inserting': [3839], '(55Kurumbail': [3845], 'Pawlitz': [3847], 'Stageman': [3851], 'Kobolt': [3855], 'Honn': [3863], 'K.V.': [3864], 'Nigam': [3865], 'Dennis': [3869], 'Eicosanoids': [3871], 'Bioactive': [3874], 'Lipids': [3875], 'Cancer,': [3877], 'Inflammation': [3878], 'Related': [3880], 'Diseases.': [3881], 'Plenum': [3882], 'Publishing': [3883], 'Corp.,': [3884], 'York1999Google': [3886], 'However,': [3888], 'reason': [3890, 4369], 'NS-398': [3892], 'preferentially': [3893], 'interacts': [3894], 'evident': [3899], 'structure.': [3902], 'Likewise,': [3903], 'crystallographic': [3904, 4098], 'analysis': [3905], 'zomepirac-derived': [3907], 'rationale': [3914], 'inhibition.': [3919], 'zomepirac-acylsulfonamide': [3921], 'breeches': [3923], 'projects': [3935], 'uncongested': [3939], 'region': [3941], 'B': [3944], 'Glu-524,': [3979], 'Because': [3993], 'residues': [3996], 'common': [3998], 'determining': [4006], 'represents': [4019], 'beautiful': [4021], 'marriage': [4022], 'chemistry': [4025], 'chemistry.': [4029], 'involvement': [4031, 4238], 'now': [4039, 4161], 'generally': [4040], 'accepted,': [4041], 'dearth': [4046], 'details': [4048], 'electron': [4051], 'transfer': [4052], 'them.': [4055], 'Furthermore,': [4056], 'proposals': [4059], 'non-peroxidatic': [4061], 'mechanisms': [4062], 'need': [4068], 'explored': [4071], '(56Tang': [4072], 'M.S.': [4073], 'Copeland': [4074], 'T.M.': [4077], '7527-7534Crossref': [4081], '(16)': [4084], 'static': [4088], 'picture': [4089], 'substrate-protein': [4091], 'inhibitor-protein': [4093], 'emerging': [4096], 'studies,': [4101], 'dynamics': [4104], 'poorly': [4109], 'Fluorescence': [4111], 'quenching': [4112], 'should': [4113], 'useful': [4116], 'studying': [4118], 'inhibitor-COX': [4119], 'real': [4122], 'time,': [4123], 'preliminary': [4125], 'studies': [4126], 'indicate': [4127], 'diarylheterocycle': [4128], 'simple': [4135], 'two-step': [4136], 'suggests': [4138], '(57Lanzo': [4139], 'C.A.': [4140], 'Beechem': [4141], 'Talley': [4143], '37:': [4149], '217-226Crossref': [4150], '(34)': [4153], 'Two': [4156], 'market': [4164], 'if': [4166], 'safe': [4170], 'general': [4173], 'population': [4174], 'clinical': [4180], 'trials': [4181], '(11Simon': [4182], 'will': [4209, 4291, 4419], 'represent': [4210], 'public': [4213], 'health': [4214], 'advance': [4215], 'reducing': [4217], 'mortality': [4218], 'ulcers.': [4221], 'Equally': [4222], 'exciting': [4223, 4361], 'knockout': [4231], 'uncovering': [4235], "enzyme's": [4237], 'wide': [4241], 'responses': [4247], 'beings': [4250], '(58DuBois': [4251], 'R.N.': [4252], 'Abramson': [4253], 'S.B.': [4254], 'Crofford': [4255], 'Gupta': [4257], 'Simon': [4259], 'de': [4262], 'Putte': [4263], 'B.A.': [4264], 'FASEB': [4267], '12:': [4270], '1063-1073Crossref': [4271], '(2225)': [4274], 'broader': [4284], 'emerge': [4292], 'exemplified': [4299], 'survey': [4302], 'patent': [4306, 4323], 'literature.': [4307], '6Information': [4308], 'regarding': [4309], 'compounds': [4310], 'patents': [4313], 'filed': [4316], 'IBM': [4322], 'server': [4324], 'web': [4325], 'reference': [4328], 'numbers': [4329], 'chromenes,': [4331], 'pyranoindoles,': [4332], 'phenylacetic': [4335], 'PCT': [4338, 4343], 'WO9847890,': [4339], 'US': [4340], '5776967,': [4341], 'WO9709977,': [4344], 'respectively.': [4345], 'Finally,': [4346], 'review': [4349], 'covered': [4352], 'regulation,': [4353], 'topic': [4355], 'extremely': [4358], 'area': [4362], 'investigation.': [4364], 'intense': [4366], 'study,': [4367], 'distinct': [4374], '(sometimes': [4377], 'same': [4381], 'cell': [4382], 'type)': [4383], 'understood;': [4386], 'source': [4388], 'incompletely': [4397], 'defined,': [4398], 'glucocorticoids': [4404], 'expression': [4407], 'certain.': [4410], 'Elucidating': [4411], 'answer': [4413], 'questions': [4416], 'fundamental': [4422], 'knowledge': [4423], 'uncover': [4427], 'new': [4428], 'targets': [4430], 'intervention': [4433], 'diseases.': [4439], 'grateful': [4442], 'Kurumbail': [4445], 'COX-2-inhibitor': [4450], 'helpful': [4453, 4470], 'discussions;': [4454], 'McKeever': [4457], 'communication': [4462], 'manuscripts;': [4465], 'discussions.': [4471], 'Download': [4472], '.pdf': [4473], '(.13': [4474], 'MB)': [4475], 'Help': [4476], 'pdf': [4478], 'files': [4479]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2066395665', 'counts_by_year': [{'year': 2024, 'cited_by_count': 11}, {'year': 2023, 'cited_by_count': 6}, {'year': 2022, 'cited_by_count': 16}, {'year': 2021, 'cited_by_count': 21}, {'year': 2020, 'cited_by_count': 15}, {'year': 2019, 'cited_by_count': 16}, {'year': 2018, 'cited_by_count': 23}, {'year': 2017, 'cited_by_count': 22}, {'year': 2016, 'cited_by_count': 14}, {'year': 2015, 'cited_by_count': 15}, {'year': 2014, 'cited_by_count': 18}, {'year': 2013, 'cited_by_count': 15}, {'year': 2012, 'cited_by_count': 16}], 'updated_date': '2025-01-01T20:55:18.577328', 'created_date': '2016-06-24'}