Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2066390723', 'doi': 'https://doi.org/10.1016/0014-5793(95)00458-l', 'title': 'Almost the entire 5′ non‐translated region of hepatitis C virus is required for cap‐independent translation', 'display_name': 'Almost the entire 5′ non‐translated region of hepatitis C virus is required for cap‐independent translation', 'publication_year': 1995, 'publication_date': '1995-05-29', 'ids': {'openalex': 'https://openalex.org/W2066390723', 'doi': 'https://doi.org/10.1016/0014-5793(95)00458-l', 'mag': '2066390723', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/7781762'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1016/0014-5793(95)00458-l', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S104830714', 'display_name': 'FEBS Letters', 'issn_l': '0014-5793', 'issn': ['0014-5793', '1873-3468'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5040263014', 'display_name': 'René Rijnbrand', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I121797337', 'display_name': 'Leiden University', 'ror': 'https://ror.org/027bh9e22', 'country_code': 'NL', 'type': 'education', 'lineage': ['https://openalex.org/I121797337']}], 'countries': ['NL'], 'is_corresponding': False, 'raw_author_name': 'René Rijnbrand', 'raw_affiliation_strings': ['Department of Virology, Institute of Medical Microbiology, Faculty of Medicine, Leiden University, Postbus 320, 2300 AH Leiden, The Netherlands'], 'affiliations': [{'raw_affiliation_string': 'Department of Virology, Institute of Medical Microbiology, Faculty of Medicine, Leiden University, Postbus 320, 2300 AH Leiden, The Netherlands', 'institution_ids': ['https://openalex.org/I121797337']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5109963373', 'display_name': 'Peter J. Bredenbeek', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I121797337', 'display_name': 'Leiden University', 'ror': 'https://ror.org/027bh9e22', 'country_code': 'NL', 'type': 'education', 'lineage': ['https://openalex.org/I121797337']}], 'countries': ['NL'], 'is_corresponding': False, 'raw_author_name': 'Peter Bredenbeek', 'raw_affiliation_strings': ['Department of Virology, Institute of Medical Microbiology, Faculty of Medicine, Leiden University, Postbus 320, 2300 AH Leiden, The Netherlands'], 'affiliations': [{'raw_affiliation_string': 'Department of Virology, Institute of Medical Microbiology, Faculty of Medicine, Leiden University, Postbus 320, 2300 AH Leiden, The Netherlands', 'institution_ids': ['https://openalex.org/I121797337']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5010266465', 'display_name': 'Tahar van der Straaten', 'orcid': 'https://orcid.org/0000-0002-1176-9849'}, 'institutions': [{'id': 'https://openalex.org/I121797337', 'display_name': 'Leiden University', 'ror': 'https://ror.org/027bh9e22', 'country_code': 'NL', 'type': 'education', 'lineage': ['https://openalex.org/I121797337']}], 'countries': ['NL'], 'is_corresponding': False, 'raw_author_name': 'Tahar van der Straaten', 'raw_affiliation_strings': ['Department of Virology, Institute of Medical Microbiology, Faculty of Medicine, Leiden University, Postbus 320, 2300 AH Leiden, The Netherlands'], 'affiliations': [{'raw_affiliation_string': 'Department of Virology, Institute of Medical Microbiology, Faculty of Medicine, Leiden University, Postbus 320, 2300 AH Leiden, The Netherlands', 'institution_ids': ['https://openalex.org/I121797337']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5001821884', 'display_name': 'Linda Whetter', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I114027177', 'display_name': 'University of North Carolina at Chapel Hill', 'ror': 'https://ror.org/0130frc33', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I114027177']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Linda Whetter', 'raw_affiliation_strings': ['Department of Medicine, The University of North Carolina at Chapel Hill, NC 27599-7030, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Medicine, The University of North Carolina at Chapel Hill, NC 27599-7030, USA', 'institution_ids': ['https://openalex.org/I114027177']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5026293971', 'display_name': 'Geneviève Inchauspé', 'orcid': 'https://orcid.org/0000-0001-8813-9418'}, 'institutions': [{'id': 'https://openalex.org/I1343675862', 'display_name': 'New York Blood Center', 'ror': 'https://ror.org/01xvcf081', 'country_code': 'US', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I1343675862']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Geneviève Inchauspé', 'raw_affiliation_strings': ['The Lindsley F. Kimball Research institute, The New York Blood Center, New York, NY 10021, USA'], 'affiliations': [{'raw_affiliation_string': 'The Lindsley F. Kimball Research institute, The New York Blood Center, New York, NY 10021, USA', 'institution_ids': ['https://openalex.org/I1343675862']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5026233059', 'display_name': 'Stanley M. Lemon', 'orcid': 'https://orcid.org/0000-0003-1450-806X'}, 'institutions': [{'id': 'https://openalex.org/I114027177', 'display_name': 'University of North Carolina at Chapel Hill', 'ror': 'https://ror.org/0130frc33', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I114027177']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Stanley Lemon', 'raw_affiliation_strings': ['Department of Medicine, The University of North Carolina at Chapel Hill, NC 27599-7030, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Medicine, The University of North Carolina at Chapel Hill, NC 27599-7030, USA', 'institution_ids': ['https://openalex.org/I114027177']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5111902815', 'display_name': 'Willy J. M. Spaan', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I121797337', 'display_name': 'Leiden University', 'ror': 'https://ror.org/027bh9e22', 'country_code': 'NL', 'type': 'education', 'lineage': ['https://openalex.org/I121797337']}], 'countries': ['NL'], 'is_corresponding': False, 'raw_author_name': 'Willy Spaan', 'raw_affiliation_strings': ['Department of Virology, Institute of Medical Microbiology, Faculty of Medicine, Leiden University, Postbus 320, 2300 AH Leiden, The Netherlands'], 'affiliations': [{'raw_affiliation_string': 'Department of Virology, Institute of Medical Microbiology, Faculty of Medicine, Leiden University, Postbus 320, 2300 AH Leiden, The Netherlands', 'institution_ids': ['https://openalex.org/I121797337']}]}], 'institution_assertions': [], 'countries_distinct_count': 2, 'institutions_distinct_count': 3, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 3610, 'currency': 'USD', 'value_usd': 3610, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 7.235, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 159, 'citation_normalized_percentile': {'value': 0.943519, 'is_in_top_1_percent': False, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 97, 'max': 98}, 'biblio': {'volume': '365', 'issue': '2-3', 'first_page': '115', 'last_page': '119'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11112', 'display_name': 'Viral Infections and Immunology Research', 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/2705', 'display_name': 'Cardiology and Cardiovascular Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11112', 'display_name': 'Viral Infections and Immunology Research', 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/2705', 'display_name': 'Cardiology and Cardiovascular Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10151', 'display_name': 'Hepatitis C virus research', 'score': 0.9991, 'subfield': {'id': 'https://openalex.org/subfields/2721', 'display_name': 'Hepatology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10521', 'display_name': 'RNA and protein synthesis mechanisms', 'score': 0.9975, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [], 'concepts': [{'id': 'https://openalex.org/C149364088', 'wikidata': 'https://www.wikidata.org/wiki/Q185917', 'display_name': 'Translation (biology)', 'level': 4, 'score': 0.6637326}, {'id': 'https://openalex.org/C159047783', 'wikidata': 'https://www.wikidata.org/wiki/Q7215', 'display_name': 'Virology', 'level': 1, 'score': 0.5881427}, {'id': 'https://openalex.org/C3019983190', 'wikidata': 'https://www.wikidata.org/wiki/Q157661', 'display_name': 'Hepatitis a virus', 'level': 3, 'score': 0.45725316}, {'id': 'https://openalex.org/C2522874641', 'wikidata': 'https://www.wikidata.org/wiki/Q808', 'display_name': 'Virus', 'level': 2, 'score': 0.36002308}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.3458158}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.16917735}, {'id': 'https://openalex.org/C105580179', 'wikidata': 'https://www.wikidata.org/wiki/Q188928', 'display_name': 'Messenger RNA', 'level': 3, 'score': 0.068264455}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.06263965}], 'mesh': [{'descriptor_ui': 'D016174', 'descriptor_name': 'Hepacivirus', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D016174', 'descriptor_name': 'Hepacivirus', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D014176', 'descriptor_name': 'Protein Biosynthesis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D012091', 'descriptor_name': 'Repetitive Sequences, Nucleic Acid', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002460', 'descriptor_name': 'Cell Line', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015500', 'descriptor_name': 'Chloramphenicol O-Acetyltransferase', 'qualifier_ui': 'Q000096', 'qualifier_name': 'biosynthesis', 'is_major_topic': False}, {'descriptor_ui': 'D015500', 'descriptor_name': 'Chloramphenicol O-Acetyltransferase', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002522', 'descriptor_name': 'Chlorocebus aethiops', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017931', 'descriptor_name': 'DNA Primers', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015870', 'descriptor_name': 'Gene Expression', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016174', 'descriptor_name': 'Hepacivirus', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007822', 'descriptor_name': 'Laryngeal Neoplasms', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016296', 'descriptor_name': 'Mutagenesis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009690', 'descriptor_name': 'Nucleic Acid Conformation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010442', 'descriptor_name': 'Peptide Chain Initiation, Translational', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017955', 'descriptor_name': 'Poliovirus', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D017955', 'descriptor_name': 'Poliovirus', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D017955', 'descriptor_name': 'Poliovirus', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016133', 'descriptor_name': 'Polymerase Chain Reaction', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015183', 'descriptor_name': 'Restriction Mapping', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017384', 'descriptor_name': 'Sequence Deletion', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014162', 'descriptor_name': 'Transfection', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014407', 'descriptor_name': 'Tumor Cells, Cultured', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1016/0014-5793(95)00458-l', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S104830714', 'display_name': 'FEBS Letters', 'issn_l': '0014-5793', 'issn': ['0014-5793', '1873-3468'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/7781762', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'score': 0.76, 'display_name': 'Good health and well-being', 'id': 'https://metadata.un.org/sdg/3'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 16, 'referenced_works': ['https://openalex.org/W1488795182', 'https://openalex.org/W1798612500', 'https://openalex.org/W1836032532', 'https://openalex.org/W1877659824', 'https://openalex.org/W1914838920', 'https://openalex.org/W1974879228', 'https://openalex.org/W1987961630', 'https://openalex.org/W1992378816', 'https://openalex.org/W2005411001', 'https://openalex.org/W203813767', 'https://openalex.org/W2048117183', 'https://openalex.org/W2066124462', 'https://openalex.org/W2073595013', 'https://openalex.org/W2087021327', 'https://openalex.org/W2161945006', 'https://openalex.org/W592099852'], 'related_works': ['https://openalex.org/W4386371748', 'https://openalex.org/W292004825', 'https://openalex.org/W2226823820', 'https://openalex.org/W2188759708', 'https://openalex.org/W2147145791', 'https://openalex.org/W2138564085', 'https://openalex.org/W2123163123', 'https://openalex.org/W2111970140', 'https://openalex.org/W2016551366', 'https://openalex.org/W1874513932'], 'abstract_inverted_index': {'To': [0], 'investigate': [1], 'which': [2, 51], 'hairpin': [3, 28, 37, 49], 'structures': [4], 'within': [5], 'the': [6, 42, 45, 61], '5′': [7, 47], 'untranslated': [8], 'region': [9], 'of': [10, 44, 60], 'hepatitis': [11], 'C': [12], 'virus': [13], '(HCV)': [14], 'are': [15], 'necessary': [16], 'for': [17, 69], 'cap‐independent': [18, 70], 'translation,': [19, 58], 'mutants': [20], 'were': [21], 'constructed': [22], 'that': [23, 40, 76], 'lack': [24], 'one': [25], 'or': [26], 'more': [27], 'structures.': [29], 'Here': [30], 'we': [31, 74], 'demonstrate,': [32], 'by': [33, 83], 'constructing': [34], 'precisely': [35], 'defined': [36], 'deletion': [38, 53], 'mutants,': [39], 'with': [41], 'exception': [43], 'most': [46], 'located': [48], 'structure,': [50], 'on': [52, 57], 'shows': [54], 'an': [55], 'increase': [56], 'each': [59], 'predicted': [62], 'hairpins': [63], 'is': [64, 81], 'found': [65], 'to': [66], 'be': [67], 'essential': [68], 'translation.': [71], 'In': [72], 'addition,': [73], 'demonstrate': [75], 'HCV': [77], '5′UTR': [78], 'driven': [79], 'translation': [80], 'stimulated': [82], 'poliovirus': [84], '2A': [85], 'pro': [86], 'co‐expression.': [87]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2066390723', 'counts_by_year': [{'year': 2022, 'cited_by_count': 1}, {'year': 2021, 'cited_by_count': 1}, {'year': 2019, 'cited_by_count': 1}, {'year': 2018, 'cited_by_count': 2}, {'year': 2016, 'cited_by_count': 1}, {'year': 2015, 'cited_by_count': 1}, {'year': 2014, 'cited_by_count': 2}, {'year': 2013, 'cited_by_count': 6}, {'year': 2012, 'cited_by_count': 2}], 'updated_date': '2024-12-11T04:30:39.495289', 'created_date': '2016-06-24'}