Publication Information

{'id': 'https://openalex.org/W2066079888', 'doi': 'https://doi.org/10.1074/jbc.m406400200', 'title': 'Histone Deacetylase Activity Is Required to Recruit RNA Polymerase II to the Promoters of Selected Interferon-stimulated Early Response Genes', 'display_name': 'Histone Deacetylase Activity Is Required to Recruit RNA Polymerase II to the Promoters of Selected Interferon-stimulated Early Response Genes', 'publication_year': 2004, 'publication_date': '2004-06-15', 'ids': {'openalex': 'https://openalex.org/W2066079888', 'doi': 'https://doi.org/10.1074/jbc.m406400200', 'mag': '2066079888', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/15194680'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1074/jbc.m406400200', 'pdf_url': 'http://www.jbc.org/article/S002192582077119X/pdf', 'source': {'id': 'https://openalex.org/S140251998', 'display_name': 'Journal of Biological Chemistry', 'issn_l': '0021-9258', 'issn': ['0021-9258', '1067-8816', '1083-351X'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'hybrid', 'oa_url': 'http://www.jbc.org/article/S002192582077119X/pdf', 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5057993656', 'display_name': 'Shuji Sakamoto', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I1316902750', 'display_name': 'Cleveland Clinic', 'ror': 'https://ror.org/03xjacd83', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1316902750']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Shuji Sakamoto', 'raw_affiliation_strings': ['Department of Immunology, Lerner Research Institute, the Cleveland Clinic Foundation, Cleveland, Ohio 44195'], 'affiliations': [{'raw_affiliation_string': 'Department of Immunology, Lerner Research Institute, the Cleveland Clinic Foundation, Cleveland, Ohio 44195', 'institution_ids': ['https://openalex.org/I1316902750']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5021216763', 'display_name': 'Ramesh Potla', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I1316902750', 'display_name': 'Cleveland Clinic', 'ror': 'https://ror.org/03xjacd83', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1316902750']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Ramesh Potla', 'raw_affiliation_strings': ['Department of Immunology, Lerner Research Institute, the Cleveland Clinic Foundation, Cleveland, Ohio 44195'], 'affiliations': [{'raw_affiliation_string': 'Department of Immunology, Lerner Research Institute, the Cleveland Clinic Foundation, Cleveland, Ohio 44195', 'institution_ids': ['https://openalex.org/I1316902750']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5076057611', 'display_name': 'Andrew C. 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'https://openalex.org/W2281613556', 'https://openalex.org/W2282986747', 'https://openalex.org/W2489635864', 'https://openalex.org/W4252179225'], 'related_works': ['https://openalex.org/W4390904861', 'https://openalex.org/W2911491601', 'https://openalex.org/W2300785998', 'https://openalex.org/W2159831588', 'https://openalex.org/W2108742077', 'https://openalex.org/W2108014213', 'https://openalex.org/W2069173821', 'https://openalex.org/W2058176071', 'https://openalex.org/W2009011435', 'https://openalex.org/W1976956267'], 'abstract_inverted_index': {'Posttranslational': [0, 205], 'modification': [1, 206], 'of': [2, 31, 38, 43, 67, 97, 120, 129, 135, 143, 156, 171, 177, 191, 197, 202, 207, 236, 243, 248, 272, 302, 325, 334, 340, 348, 361, 376, 382, 396, 402, 407, 413, 430, 444, 471, 482, 500, 526, 533, 603, 611, 616, 631, 672, 682, 727, 735, 853, 874, 965, 971, 984, 1001, 1072, 1077, 1104, 1110, 1118, 1140, 1147, 1154, 1245, 1300, 1365, 1451, 1461, 1567, 1580, 1588, 1867, 1889, 1912, 1934, 1941, 1964, 1976, 1978, 1990, 1997, 2021, 2029, 2061, 2081, 2090, 2101, 2118, 2186, 2198, 2204, 2207, 2224, 2255, 2263, 2285, 2293, 2320, 2334, 2344, 2364, 2379, 2382, 2396, 2402, 2417, 2427, 2467, 2517, 2588, 2593, 2611, 2625, 2633, 2664, 2704, 2721, 2740, 2754, 2775, 2782, 2791, 2809, 2829, 2839, 2848, 2852, 2912, 2928, 2944, 2956, 2963, 3041, 3066, 3103, 3108, 3114, 3122, 3126, 3130, 3136, 3145, 3149, 3155, 3163, 3173, 3215, 3230, 3242, 3248, 3306, 3312, 3327, 3406, 3431, 3438, 3478, 3481, 3485, 3534, 3536, 3543, 3573, 3589, 3677, 3684, 3709, 3713, 3737, 3745, 3747, 3771, 3811, 3826, 3833, 3840, 3844, 3855, 3867, 3881, 3907, 3920, 3928, 3966, 3974], 'histones': [3, 33, 208, 238, 3216], 'by': [4, 87, 117, 166, 209, 292, 322, 371, 478, 625, 951, 959, 974, 992, 1019, 1025, 1048, 1087, 1307, 1363, 1509, 1550, 1774, 1982, 2094, 2342, 2415, 2439, 2822, 3008, 3341, 3352, 3389, 3396, 3460, 3502, 3529], 'acetylation,': [5, 210, 3219], 'methylation': [6, 211, 3222], 'or': [7, 41, 131, 146, 212, 246, 336, 351, 613, 1067, 1085, 1537, 1569, 1585, 1646, 1649, 1742, 1887, 2059, 2071, 2200, 2202, 2238, 2289, 2456, 2465, 2483, 2519, 2649, 2737, 2856, 2883, 2894, 2897, 2931, 3062, 3095, 3101, 3221, 3253, 3433, 3743, 3799], 'phosphorylation': [8, 128, 213, 333, 532, 2028, 2080, 2089, 2100, 2117, 2197, 2203], 'has': [9, 214, 3255, 3425], 'emerged': [10, 215], 'as': [11, 216, 667, 669, 679, 1043, 1254, 1466, 1772, 1832, 1927, 2085, 2087, 2265, 2717, 3082, 3258, 3268], 'a': [12, 51, 60, 106, 217, 256, 265, 311, 524, 592, 680, 954, 1029, 1039, 1126, 1242, 1514, 1596, 1970, 2242, 2357, 2484, 2490, 2975, 2986, 3335, 3390, 3580], 'major': [13, 218], 'mechanism': [14, 219, 2821], 'to': [15, 49, 58, 105, 122, 148, 160, 183, 188, 220, 254, 263, 310, 327, 353, 365, 388, 393, 518, 530, 550, 556, 562, 570, 591, 618, 714, 900, 910, 1054, 1057, 1069, 1080, 1096, 1137, 1167, 1448, 1513, 1595, 1760, 1907, 1987, 2036, 2109, 2113, 2220, 2230, 2241, 2267, 2409, 2423, 2430, 2509, 2514, 2598, 2613, 2636, 2638, 2668, 2708, 2727, 2744, 2758, 2779, 2795, 2806, 2811, 2817, 2833, 3036, 3052, 3117, 3207, 3238, 3377, 3420, 3435, 3489, 3609, 3686, 3704, 3715, 3765, 3777, 3784, 3875, 3952, 3961], 'modify': [16, 221], 'chromatin': [17, 48, 222, 253, 629, 683, 2475, 2495, 2505], 'structure': [18, 223, 630], 'and': [19, 92, 224, 297, 428, 493, 502, 535, 539, 548, 589, 709, 721, 863, 976, 1099, 1158, 1172, 1239, 1455, 1511, 1548, 1553, 1713, 1753, 1758, 1816, 1891, 1901, 1917, 1945, 2008, 2015, 2031, 2033, 2046, 2066, 2083, 2103, 2111, 2228, 2306, 2389, 2404, 2406, 2434, 2474, 2478, 2596, 2608, 2610, 2621, 2647, 2653, 2685, 2793, 2875, 2906, 2950, 2971, 2985, 2993, 3086, 3184, 3234, 3322, 3354, 3424, 3454, 3531, 3603, 3694, 3768, 3790, 3873, 3914, 3955], 'gene': [20, 225, 434, 443, 676, 738, 861, 941, 1005, 1106, 1169, 1873, 3329], 'expression.': [21, 226, 1170], 'In': [22, 227, 2656, 3570], 'most': [23, 228, 2375, 3169], 'cases,': [24, 229], 'transcriptionally': [25, 230, 3210], 'active': [26, 231, 3211], 'genes': [27, 83, 232, 288, 604, 620, 633, 904, 945, 972, 989, 1013, 1034, 1141, 2783, 3266, 3383, 3526, 3545], 'display': [28, 233], 'enhanced': [29, 234, 2702, 3547], 'binding': [30, 104, 142, 155, 235, 309, 347, 360, 517, 1136, 2223, 2426, 2592, 2663, 2703, 2723, 2739, 2753, 2790, 2816, 2828, 2977, 3334, 3430, 3456, 3712, 3764], 'acetylated': [32, 237, 729, 3602], 'in': [34, 111, 239, 316, 579, 600, 627, 724, 898, 907, 931, 946, 953, 968, 987, 1014, 1035, 1107, 1131, 1160, 1178, 1310, 1369, 1655, 1763, 1830, 1869, 1884, 1923, 1952, 2056, 2271, 2310, 2393, 2462, 2691, 2712, 2724, 2762, 2836, 2979, 2995, 3032, 3047, 3083, 3091, 3098, 3133, 3176, 3262, 3293, 3375, 3384, 3415, 3451, 3585, 3726, 3740, 3773, 3941, 3959], 'their': [35, 240, 519, 543, 1953, 2034, 2129, 2407, 3378, 3607], 'promoters.': [36, 241, 1954, 3240], 'Activation': [37, 242], 'histone': [39, 44, 203, 244, 249, 408, 462, 718, 730, 1156, 3244, 3249], 'acetyltransferases': [40, 245, 1157], 'inhibition': [42, 247, 1977, 1996, 3405], 'deacetylases': [45, 250], '(HDACs)': [46, 251], 'allows': [47, 252], 'assume': [50, 255], 'more': [52, 257, 1030, 2329], 'open': [53, 258], 'state': [54, 259], 'permitting': [55, 260], 'transcriptional': [56, 261], 'activators': [57, 262], 'form': [59, 264, 563, 587, 3687], 'preinitiation': [61, 266], 'complex.': [62, 267], 'To': [63, 268, 961, 996, 1863, 2017, 2249, 2443, 2844, 3028], 'our': [64, 269, 997, 3577, 3668], 'surprise,': [65, 270], 'treatment': [66, 134, 271, 339, 1984, 2343, 2587, 2624, 3676, 3708], 'cells': [68, 121, 136, 273, 326, 341, 854, 908, 1309, 1738, 1935, 2022, 2187, 2311, 2321, 2345, 2353, 2418, 2626, 2692, 2714, 2725, 2866, 2890, 2913, 3076, 3092, 3678, 3710, 3748, 3921], 'with': [69, 274, 655, 704, 716, 732, 855, 1142, 1165, 1184, 1471, 1522, 1564, 1744, 1936, 2006, 2023, 2043, 2054, 2188, 2313, 2322, 2346, 2356, 2419, 2455, 2472, 2480, 2499, 2511, 2681, 2694, 2867, 2893, 2914, 2990, 3077, 3094, 3182, 3209, 3411, 3447, 3473, 3679, 3691, 3749, 3796, 3877, 3922, 3931, 3970, 3984], 'the': [70, 88, 141, 149, 161, 174, 189, 200, 275, 293, 346, 354, 366, 379, 394, 405, 469, 479, 551, 564, 601, 609, 628, 663, 670, 717, 728, 733, 736, 867, 875, 963, 969, 982, 999, 1070, 1097, 1105, 1108, 1115, 1138, 1145, 1152, 1366, 1449, 1452, 1456, 1544, 1581, 1589, 1718, 1723, 1764, 1865, 1885, 1910, 1924, 1979, 1988, 1991, 2057, 2222, 2252, 2261, 2272, 2283, 2286, 2290, 2294, 2335, 2361, 2365, 2380, 2387, 2394, 2431, 2463, 2515, 2591, 2599, 2614, 2631, 2639, 2662, 2669, 2682, 2709, 2719, 2735, 2745, 2759, 2780, 2789, 2796, 2807, 2818, 2827, 2834, 2837, 2840, 2849, 2941, 2960, 2996, 3038, 3048, 3058, 3067, 3078, 3099, 3109, 3119, 3127, 3131, 3134, 3137, 3142, 3150, 3156, 3160, 3174, 3243, 3316, 3325, 3421, 3429, 3436, 3448, 3474, 3479, 3532, 3541, 3571, 3587, 3673, 3682, 3716, 3741, 3755, 3766, 3769, 3809, 3828, 3837, 3845, 3852, 3868, 3879, 3932, 3939, 3949, 3963, 3971, 3985], 'HDAC': [71, 276, 856, 934, 966, 1051, 1957, 2441, 2769, 2824, 3299, 3343, 3407, 3493, 3857], 'inhibitor,': [72, 277], 'trichostatin': [73, 278, 448], 'A': [74, 279, 1234], '(TSA),': [75, 280], 'inhibits': [76, 281, 3606], 'selected': [77, 282], 'interferon': [78, 108, 283, 313, 458, 465, 557, 594], 'β': [79, 284], '(IFNβ)-stimulated': [80, 285], 'immediate': [81, 286, 472], 'early': [82, 287, 473, 3264], 'that': [84, 180, 289, 385, 528, 576, 605, 675, 851, 930, 1881, 1999, 2374, 2501, 2768, 2784, 2879, 2988, 3055, 3227, 3298, 3382, 3404, 3465, 3469, 3596, 3604, 3675, 3724, 3759, 3808, 3824, 3903, 3918, 3938, 3943, 3968], 'are': [85, 290, 476, 905, 957, 990, 1120, 2384, 3006, 3034, 3223, 3314, 3393, 3497, 3601, 3818, 3958], 'activated': [86, 291, 950, 1968], 'transcription': [89, 294, 483, 565, 994, 3236], 'factors': [90, 295, 484, 3237], 'Stat1': [91, 102, 130, 296, 307, 335, 534, 538, 585, 708, 975, 1066, 1647, 1826, 2030, 2082, 2091, 2102, 2122, 2199, 2208, 2239, 2403, 2595, 2612, 2792, 2930, 2992, 3183, 3252, 3332, 3432, 3693, 3872, 3913, 3954], 'Stat2.': [93, 132, 298, 337, 536, 3915, 3956], 'However,': [94, 153, 299, 358, 897, 1955, 2729, 2788, 3374, 3699], 'IFNβ': [95, 300, 1226, 1745, 1892, 2055, 2302, 2332, 2400, 2458, 2586, 2695, 2896, 3097], 'activation': [96, 109, 301, 314, 459, 470, 595, 677, 1037, 1143, 2401, 3386], 'IRF-1,': [98, 303, 1044, 1915, 1965], 'which': [99, 304, 475, 947, 988, 1015, 1036, 1947, 1966, 2823, 3030, 3385], 'requires': [100, 199, 305, 404, 3492], 'tyrosine-phosphorylated': [101, 306, 584, 2991, 3692, 3912], 'homodimers': [103, 308, 588, 2240, 3333], 'γ': [107, 312, 457, 593], 'sequence': [110, 315, 596, 1460, 1584, 1592, 2363], 'its': [112, 317, 2980, 3001, 3180, 3412, 3455], 'promoter': [113, 163, 190, 318, 368, 395, 602, 734, 1071, 1098, 1139, 1454, 1463, 1601, 2288, 2296, 2367, 2601, 2616, 2671, 2711, 2761, 2781, 2798, 2835, 3450, 3475, 3767], 'is': [114, 164, 319, 369, 577, 623, 865, 949, 1017, 1093, 1101, 1967, 1985, 2105, 2126, 2771, 2801, 2842, 3204, 3301, 3338, 3387, 3445, 3457, 3470, 3476, 3822, 3944, 3946], 'not': [115, 125, 139, 320, 330, 344, 607, 1046, 1065, 1121, 1960, 2124, 2340, 2369, 2377, 2390, 2413, 2733, 2750, 2803, 3171, 3315, 3339, 3394, 3458, 3671, 3702, 3730, 3734, 3752, 3806, 3819, 3910, 3925], 'affected': [116, 321, 2414, 3395], 'TSA.': [118, 167, 323, 372, 960, 2347, 2468, 2728, 3123, 3164, 3397, 3461], 'Exposure': [119, 324], 'TSA': [123, 133, 328, 338, 911, 1002, 1049, 1078, 1119, 1890, 1937, 1983, 1995, 2024, 2062, 2189, 2256, 2323, 2383, 2623, 2659, 2731, 2898, 2915, 2945, 2964, 3104, 3313, 3680, 3707, 3750, 3923, 3967], 'does': [124, 138, 329, 343, 3924], 'alter': [126, 140, 331, 345, 2734, 3228], 'tyrosine': [127, 332, 531, 2027, 2079, 2196], 'also': [137, 342, 2497, 3400], 'Stat': [144, 349, 480, 2635], '1': [145, 350, 514, 1324, 1335, 1382, 1393, 1565, 1871, 2620], 'Stat2': [147, 352, 540, 612, 710, 1644, 1815, 2032, 2084, 2104, 2201, 2405, 2597, 2794, 2932, 2994, 3185, 3254, 3434, 3695, 3874], 'endogenous': [150, 355, 2432, 3422, 3717], 'ISG54': [151, 162, 356, 367, 739, 1590, 2014, 2264, 2287, 2433, 2518, 2600, 2640, 2670, 2760, 2797, 2869, 3079, 3269, 3439, 3718, 3986], 'promoter.': [152, 357], 'IFNβ-stimulated': [154, 359, 2026, 2078, 2195, 2325, 2917, 3574], 'RNA': [157, 185, 362, 390, 450, 453, 1059, 1133, 1248, 1817, 1898, 2485, 2665, 2676, 2705, 2741, 2755, 2776, 2813, 2830, 3231, 3417, 3442, 3466, 3486, 3537, 3761, 3791, 3800, 3814], 'polymerase': [158, 186, 363, 391, 454, 1060, 2486, 3232, 3418], 'II': [159, 187, 364, 392, 1061, 1092, 1135, 1819, 2667, 2678, 2707, 2743, 2757, 2778, 2815, 2832, 3233, 3419, 3444, 3468, 3488, 3539, 3763, 3793, 3802, 3816], 'prevented': [165, 370], 'Interestingly,': [168, 373, 943, 1089, 3124], 'ectopic': [169, 374], 'expression': [170, 375, 873, 948, 970, 983, 1006, 1016, 1103, 1720, 1874, 1940, 2877, 2955, 3050, 3125, 3148, 3305, 3326, 3825, 3843], 'IRF9': [172, 181, 198, 377, 386, 403, 1130, 1650, 1719, 2884, 2957, 2973, 3033, 3049, 3115, 3177, 3584, 3685, 3714, 3722, 3738, 3772, 3789, 3798, 3812, 3834, 3908, 3942], 'reverses': [173, 378, 3836, 3851], 'inhibitory': [175, 380, 2253, 2942, 2961, 3039, 3120, 3143, 3161, 3310, 3838, 3853], 'actions': [176, 381, 412, 1000, 1117, 2254, 2381, 2943, 2962, 3040, 3121, 3162, 3588, 3839], 'TSA,': [178, 383, 447, 1026, 2420, 3042, 3146, 3530, 3841], 'suggesting': [179, 384, 674, 929], 'functions': [182, 387, 3725], 'recruit': [184, 389, 1058], 'interferon-stimulated': [192, 397, 423, 433, 438, 442, 572, 632], 'genes.': [193, 398, 582, 1074, 2398, 2655, 3212, 3308], 'This': [194, 399, 3165, 3462], 'particular': [195, 400], 'function': [196, 401, 1128, 2132, 3770], 'activity': [201, 406, 935, 967, 1052, 1146, 1755, 2328, 2338, 2770, 2825, 2908, 2920, 3088, 3300, 3408, 3480], 'deacetylases.': [204, 409], 'The': [410, 497, 1075, 1518, 1814, 1973, 2700, 2820, 3070, 3309, 3916], 'biological': [411], 'interferons': [414, 515], '(IFNs)': [415], '1The': [416], 'abbreviations': [417], 'used': [418, 1240, 1465, 1876], 'are:': [419], 'IFN,': [420], 'interferon;': [421], 'ISG,': [422], 'gene;': [424], 'Stat,': [425], 'signal': [426], 'transducer': [427], 'activator': [429], 'transcription;': [431], 'ISGF3,': [432, 3929], 'factor': [435, 559], '3;': [436], 'ISRE,': [437], 'response': [439, 573, 1458, 3265], 'element;': [440], 'ISG54,': [441, 1913, 1942], '54': [445], 'kDa;': [446], 'A;': [449], 'Pol': [451, 1091, 1134, 1818, 2666, 2677, 2706, 2742, 2756, 2777, 2814, 2831, 3443, 3467, 3487, 3538, 3762, 3792, 3801, 3815], 'II,': [452], 'II;': [455], 'GAS,': [456], 'sequence;': [460], 'HDAC,': [461, 2862], 'deacetylase;': [463], 'IRF,': [464], 'regulatory': [466, 558, 2269], 'factor.': [467], 'require': [468, 608], 'genes,': [474, 3321, 3576], 'mediated': [477, 1082, 3388], 'family': [481, 3599], '(1Larner': [485], 'A.C.': [486, 1208, 1268, 1425, 1488, 1797, 1836, 2145, 2542], 'Keightley': [487], 'A.': [488, 751, 787, 836, 913, 1194, 1196, 1290, 1411, 1413, 1629, 1783, 1785, 2528, 2530, 3365, 3507, 3561, 3613, 3639, 3641, 3645], 'Gutkind': [489], 'J.S.': [490], 'Signaling': [491, 1531], 'Networks': [492], 'Cell': [494, 807, 1301, 1749, 3281], 'Cycle': [495], 'Control:': [496], 'Molecular': [498], 'Basis': [499], 'Cancer': [501], 'Other': [503], 'Diseases.': [504], '1st': [505], 'Ed.': [506], 'Humana': [507], 'Press,': [508], 'Totowa,': [509], 'NJ2000:': [510], '393-409Google': [511], 'Scholar).': [512, 652, 702, 844, 896, 1224, 1298, 1441, 1499, 1641, 1705, 1813, 1862, 2184, 2585, 3027, 3201, 3290, 3373, 3569], 'Type': [513], '(IFNα/β)': [516], 'cell': [520, 1303, 1312, 1505, 2068, 2902], 'surface': [521], 'receptors': [522], 'initiate': [523], 'set': [525], 'events': [527, 3226], 'leads': [529], 'Tyrosine-phosphorylated': [537], 'heterodimerize': [541], 'through': [542, 1969, 2260, 3218, 3246], 'Src': [544], 'homology': [545], '2': [546, 1896, 2652], 'domains': [547, 3005, 3031], 'translocate': [549], 'nucleus': [552], 'where': [553, 3523], 'they': [554], 'bind': [555, 590, 2037, 2112, 2410, 2637, 3610, 3911, 3953], '9': [560], '(IRF9)': [561], 'complex': [566, 3690], 'ISGF3.': [567], 'ISGF3': [568, 617, 2225, 2853], 'binds': [569], 'an': [571, 598, 1020, 1928, 1950, 2001, 2231, 2786, 2868, 3259, 3688, 3721, 3786], 'element': [574, 2244, 2292, 3337], '(ISRE)': [575], 'present': [578], 'many': [580], 'IFNα/β-stimulated': [581, 737, 1004, 1012, 3263], 'Alternatively,': [583], 'can': [586], '(GAS),': [597], 'enhancer': [599, 3392], 'do': [606, 3670], 'participation': [610], 'IRF9.': [614, 1088, 3975], 'Binding': [615], 'cellular': [619], 'containing': [621, 2281, 2360], 'ISREs': [622], 'accompanied': [624], 'changes': [626], '(ISGs)': [634], '(2Mirkovitch': [635, 685], 'J.': [636, 686, 884, 1192, 1209, 1409, 1426, 1610, 1633, 1666, 1690, 1781, 1798, 2526, 2543, 2570, 3622, 3652], 'Decker': [637, 687], 'T.': [638, 688, 1200, 1417, 1687, 1789, 2534, 3016, 3190, 3889], 'Darnell': [639, 689, 827, 2567], 'Jr.,': [640, 690, 828, 2568], 'J.E.': [641, 691, 829, 2569], 'Mol.': [642, 692, 886, 918, 1269, 1489, 2174, 3019, 3193, 3512, 3892], 'Cell.': [643, 693, 887, 919, 1270, 1490, 2175, 3020, 3194, 3513, 3893], 'Biol.': [644, 694, 808, 888, 920, 1210, 1271, 1427, 1491, 1611, 1667, 1691, 1799, 2176, 2544, 2571, 3021, 3195, 3282, 3514, 3623, 3653, 3894], '1992;': [645, 695, 1272, 1291, 1492], '12:': [646, 696, 1273, 1493], '1-9Crossref': [647, 697], 'PubMed': [648, 698, 758, 791, 812, 840, 892, 924, 1220, 1275, 1294, 1437, 1495, 1621, 1637, 1677, 1701, 1809, 1858, 2150, 2180, 2554, 2581, 3025, 3199, 3286, 3369, 3518, 3565, 3633, 3663, 3898], 'Scopus': [649, 699, 759, 792, 813, 841, 893, 925, 1221, 1276, 1295, 1438, 1496, 1622, 1638, 1678, 1702, 1810, 1859, 2151, 2181, 2555, 2582, 3287, 3370, 3519, 3566, 3634, 3664], '(51)': [650, 700], 'Google': [651, 701, 761, 794, 815, 843, 895, 927, 1223, 1278, 1297, 1440, 1498, 1624, 1640, 1680, 1704, 1812, 1861, 2153, 2183, 2557, 2584, 3026, 3200, 3289, 3372, 3521, 3568, 3636, 3666, 3899], 'Cells': [653, 1171, 2051, 2469], 'incubated': [654, 1883, 2053, 2454, 2693, 2892, 3093], 'IFNα': [656], 'show': [657], 'altered': [658, 1047, 2341, 2438, 3340], 'DNase': [659], 'I': [660], 'sensitivity': [661], 'surrounding': [662], 'TATA': [664], 'box': [665], 'region': [666, 1459, 2270], 'well': [668, 2086, 3205, 3224], 'ISRE': [671, 1021, 1450, 1568, 1591, 1951, 2002, 2232, 2262, 2284, 2362, 2388, 2841, 2918, 3437, 3987], 'ISGs,': [673], 'occurs': [678], 'result': [681], 'remodeling': [684, 3203], 'Consistent': [703], 'this': [705, 864, 1956, 2440, 2445, 2686, 2722, 3294, 3342, 3774, 3856, 3904], 'observation,': [706], 'both': [707, 1155, 2041, 2304, 2594], 'have': [711, 979, 3594, 3781], 'been': [712, 3256, 3782], 'shown': [713, 1986], 'interact': [715, 3876, 3969], 'acetylases': [719, 3250], 'CBP/p300': [720], 'GCN5': [722], 'resulting': [723], 'increased': [725, 2690], 'association': [726, 2687], 'H3': [731, 3245], '(3Bhattacharya': [740], 'S.': [741, 745, 786, 835, 1190, 1289, 1407, 1689, 1779, 2524, 3364, 3560], 'Eckner': [742], 'R.': [743, 1198, 1415, 1627, 1787, 2141, 2532], 'Grossman': [744], 'Oldread': [746], 'E.': [747, 768, 801, 878, 2560, 3275, 3643], 'Arany': [748], 'Z.': [749], "D'Andrea": [750], 'Livingston': [752], 'D.M.': [753], 'Nature.': [754], '1996;': [755, 837], '383:': [756], '344-347Crossref': [757], '(423)': [760, 842], 'Scholar,': [762, 795, 816, 1279, 1625, 1681, 2154, 2558, 3637], '4Horvai': [763], 'A.E.': [764], 'Xu': [765], 'L.': [766, 2171], 'Korzus': [767], 'Brard': [769], 'G.': [770, 1206, 1423, 1795, 2173, 2540], 'Kalafus': [771], 'D.': [772, 824, 2167], 'Mullen': [773], 'T.-M.': [774], 'Rose': [775], 'D.W.': [776], 'Rosenfeld': [777], 'M.G.': [778], 'Glass': [779], 'C.K.': [780], 'Proc.': [781, 830, 1284, 3360, 3556], 'Natl.': [782, 831, 1285, 3361, 3557], 'Acad.': [783, 832, 1286, 3362, 3558], 'Sci.': [784, 833, 1287], 'U.': [785, 820, 834, 1288, 3363, 3559], '1997;': [788, 1693], '94:': [789], '1074-1079Crossref': [790], '(388)': [793], '5Paulson': [796], 'M.': [797, 1838, 2134, 3271], 'Press': [798, 3272], 'C.': [799, 1631, 2139, 3273], 'Smith': [800, 3274, 3642], 'Tanese': [802, 3276], 'N.': [803, 2566, 3277], 'Levy': [804, 3017, 3191, 3278, 3648, 3890], 'D.E.': [805, 3018, 3192, 3279, 3649, 3891], 'Nat.': [806, 3280], '2002;': [809, 2573, 3283, 3655], '4:': [810, 3284], '140-147Crossref': [811, 3285], '(93)': [814, 3288], '6Zhang': [817], 'J.J.': [818], 'Vinkemeier': [819], 'Gu': [821], 'W.': [822, 1202, 1419, 1791, 2156, 2536], 'Chakravarti': [823], 'Horvath': [825, 1608, 1664, 3355, 3358, 3554, 3980], 'C.M.': [826, 1609, 1665, 3359, 3555], '93:': [838], '15092-15096Crossref': [839], 'From': [845], 'these': [846, 993, 2314, 2428], 'observations': [847], 'one': [848, 870, 3328], 'would': [849, 858, 3901, 3909], 'predict': [850], 'incubation': [852, 1734, 2020, 2319, 2416, 3746, 3919], 'inhibitors': [857], 'increase': [859], 'IFN-activated': [860], 'expression,': [862], 'indeed': [866], 'case': [868, 3572], 'when': [869, 2352, 3548], 'examines': [871], 'IFNγ-stimulated': [872], 'MHC-II': [876], '(7Zika': [877], 'Greer': [879], 'S.F.': [880], 'Zhu': [881, 1201, 1418, 1790, 2535], 'X.-S.': [882], 'Ting': [883], 'P.-Y.': [885], '2003;': [889, 921, 1613, 1669, 3366, 3515, 3562, 3625], '23:': [890, 922, 3516], '3091-3102Crossref': [891], '(84)': [894], 'contrast': [899, 3376], 'IFNγ,': [901], 'interleukin-3-activated': [902], 'Stat5-dependent': [903, 3525], 'inhibited': [906, 1938, 2012, 2324, 2661, 2916, 3528, 3551], 'exposed': [909, 2726], '(8Rascle': [912, 3506], 'Johnston': [914, 3508], 'J.A.': [915, 3509], 'Amati': [916, 3510], 'B.': [917, 3511], '4162-4173Crossref': [923, 3517], '(118)': [926, 3520], 'Scholar),': [928, 3522, 3667], 'certain': [932, 2119], 'contexts': [933], 'may': [936], 'be': [937, 1055, 1081, 2859, 3778], 'required': [938, 1038, 1056, 2106, 2127, 2772, 3035, 3178, 3302, 3870], 'for': [939, 981, 1129, 1353, 1746, 1895, 1909, 2063, 2107, 2128, 2459, 2492, 2773, 2861, 2899, 3179, 3303, 3583, 3757, 3871, 3981], 'Stat-dependent': [940], 'activation.': [942], 'other': [944, 2391, 3235], 'interleukin-3': [952], 'Stat5-independent': [955], 'manner': [956], 'unaffected': [958], 'examine': [962, 1864, 3705], 'role': [964, 1866, 3414, 3582], 'regulated': [973, 1018], 'Stat2,': [977, 1068, 1536, 2227, 2482, 2855, 2882], 'we': [978, 1875, 2039, 2274, 2421, 2447, 2863, 3043, 3380], 'assayed': [980], 'several': [985, 3597], 'RNAs': [986], 'controlled': [991], 'factors.': [995], 'surprise': [998], 'on': [1003, 2193, 2630, 2940, 3318, 3428, 3813], 'were': [1007, 1022, 1045, 1176, 1252, 1305, 1357, 1361, 1464, 1469, 1507, 1557, 1715, 1739, 1751, 1770, 1821, 1882, 1905, 2052, 2076, 2213, 2257, 2297, 2350, 2354, 2453, 2470, 2891, 2904, 3072, 3527, 3550], 'relatively': [1008], 'selective.': [1009], 'Whereas': [1010], 'some': [1011, 1656], 'strongly': [1023], 'suppressed': [1024], 'others': [1027], 'showed': [1028], 'modest': [1031], 'inhibition.': [1032], 'Furthermore,': [1033], 'GAS': [1040, 1570, 1583, 1971, 2243, 2291, 3336, 3391], 'element,': [1041], 'such': [1042, 3267], 'treatment.': [1050], 'appears': [1053], '(Pol': [1062], 'II),': [1063], 'but': [1064, 3170, 3805], 'TSA-sensitive': [1073, 3945], 'effects': [1076, 3144, 3311, 3810, 3854], 'seem': [1079], 'either': [1083, 1577, 2194, 2282, 2634, 2929, 3057, 3217, 3739, 3797], 'directly': [1084, 2804, 3409], 'indirectly': [1086], 'if': [1090, 2376], 'already': [1094, 3471], 'bound': [1095], 'there': [1100], 'basal': [1102, 2736], 'absence': [1109, 1888, 2060, 2466, 3102, 3744], 'IFNα/β': [1111], '(i.e.': [1112], 'IRF-1),': [1113], 'then': [1114, 2507], 'suppressive': [1116], 'observed.': [1122], 'These': [1123, 1149, 1574, 2211, 2371, 2765, 3004, 3345, 3495], 'data': [1124], 'suggest': [1125, 2767, 3902], 'novel': [1127], 'promoting': [1132], 'requiring': [1144, 3331], 'HDACs.': [1148, 3590], 'results': [1150, 2349, 2372, 2766, 3346, 3399, 3496, 3669, 3880], 'highlight': [1151], 'importance': [1153], 'HDACs': [1159, 1868, 2810, 3549, 3758], 'controlling': [1161], 'potentially': [1162], 'distinct': [1163, 3498, 3947], 'targets': [1164, 2860, 3965], 'regard': [1166], 'Stat-regulated': [1168], 'Culture—Human': [1173], 'foreskin': [1174], 'fibroblasts': [1175, 1880, 2452, 2589], 'maintained': [1177], "Dulbecco's": [1179], 'modified': [1180], "Eagle's": [1181], 'medium': [1182], 'supplemented': [1183], '10%': [1185], 'fetal': [1186], 'calf': [1187], 'serum': [1188], '(9Sakamoto': [1189, 1406, 1778, 2523], 'Qin': [1191, 1408, 1780, 2525], 'Navarro': [1193, 1410, 1782, 2527], 'Gamero': [1195, 1412, 1784, 2529], 'Potla': [1197, 1414, 1786, 2531], 'Yi': [1199, 1416, 1788, 2533], 'Baker': [1203, 1420, 1792, 2537], 'D.P.': [1204, 1421, 1793, 2538], 'Feldman': [1205, 1422, 1794, 1839, 2539], 'Larner': [1207, 1267, 1424, 1487, 1796, 2144, 2541], 'Chem.': [1211, 1428, 1612, 1668, 1692, 1800, 2545, 2572, 3624, 3654], '2004;': [1212, 1429, 1801, 2546], '279:': [1213, 1430, 1802, 2547], '3245-3253Abstract': [1214, 1431, 1803, 2548], 'Full': [1215, 1217, 1432, 1434, 1616, 1618, 1672, 1674, 1696, 1698, 1804, 1806, 2549, 2551, 2576, 2578, 3628, 3630, 3658, 3660], 'Text': [1216, 1218, 1433, 1435, 1617, 1619, 1673, 1675, 1697, 1699, 1805, 1807, 2550, 2552, 2577, 2579, 3629, 3631, 3659, 3661], 'PDF': [1219, 1436, 1620, 1676, 1700, 1808, 2553, 2580, 3632, 3662], '(26)': [1222, 1439, 1811, 2556], 'Human': [1225, 2451], '(Avonex)': [1227], 'was': [1228, 1235, 1520, 1546, 1653, 1756, 1828, 1899, 1921, 2003, 2092, 2339, 2412, 2437, 2476, 2496, 2506, 2688, 2715, 2718, 2909, 3089, 3546, 3701, 3729], 'obtained': [1229, 1236], 'from': [1230, 1237, 1503, 1823, 3499, 3540, 3948], 'Biogen': [1231], 'Inc.': [1232], 'Trichostatin': [1233], 'Sigma': [1238], 'at': [1241, 1350, 1708, 1735, 3000, 3323], 'final': [1243], 'concentration': [1244], '200': [1246, 1341, 1399], 'ng/ml.': [1247], 'Assays—RNase': [1249], 'protection': [1250, 1903, 1993], 'assays': [1251, 1769, 1904, 2219, 3728], 'performed': [1253, 1771, 1906, 2040, 2275, 2448], 'described': [1255, 1773, 1834, 3225], 'previously': [1256, 1833], '(10Petricoin': [1257, 1477], 'E.F.': [1258, 1478, 1851, 2137], 'Hackett': [1259, 1479, 1843], 'R.H.': [1260, 1480, 1844], 'Akai': [1261, 1481], 'H.': [1262, 1482, 3617], 'Igarashi': [1263, 1483, 1841], 'K.': [1264, 1484, 1683, 1842, 2160, 2169, 3619, 3621], 'Finbloom': [1265, 1282, 1485, 1852], 'D.S.': [1266, 1283, 1486, 1853], '4486-4495Crossref': [1274, 1494], '(18)': [1277, 1497], '11Wilson': [1280], 'K.C.': [1281], '89:': [1292], '11964-11968Crossref': [1293], '(81)': [1296], 'Preparation': [1299], 'Extracts—Whole': [1302], 'extracts': [1304, 1360, 1506, 2075, 2903], 'prepared': [1306, 1362], 'lysing': [1308], 'whole': [1311, 1504, 2067], 'extraction': [1313, 1371], 'buffer': [1314, 1372], '(20': [1315, 1373], 'mm': [1316, 1319, 1322, 1325, 1333, 1336, 1339, 1346, 1374, 1377, 1380, 1383, 1391, 1394, 1397, 1404], 'Hepes,': [1317, 1375], '300': [1318, 1376], 'NaCl,': [1320, 1378], '10': [1321, 1332, 1354, 1379, 1390], 'KCl,': [1323, 1381], 'MgCl2,': [1326, 1384], '20%': [1327, 1385], 'glycerol,': [1328, 1386], '1%': [1329], 'Nonidet': [1330, 1388], 'P-40,': [1331, 1389], 'β-glycerophosphate,': [1334, 1392], 'orthovanadate,': [1337, 1395], '25': [1338, 1396], 'NaF,': [1340, 1398], 'μm': [1342, 1400], 'phenylmethylsulfonyl': [1343, 1401], 'fluoride,': [1344, 1402], '0.5': [1345, 1403], 'dithiothreitol).': [1347], 'After': [1348, 1732], 'centrifugation': [1349], '4': [1351], '°C': [1352], 'min,': [1355, 2065], 'supernatants': [1356], 'collected.': [1358], 'Nuclear': [1359], 'resuspension': [1364], 'crude': [1367], 'nuclei': [1368], 'nuclear': [1370, 2072], '0.1%': [1387], 'dithiothreitol)': [1405], 'Electrophoretic': [1442], 'Mobility': [1443], 'Shift': [1444], 'Assays—Double-stranded': [1445], 'oligonucleotides': [1446], 'corresponding': [1447, 2513], 'ISG15': [1453, 2007, 2366], 'IFNγ': [1457], 'FcγRI': [1462], 'probes.': [1467], 'They': [1468], 'end-labeled': [1470], '[γ-32P]ATP': [1472], 'using': [1473, 1559, 1722, 2096, 2215, 3794], 'T4': [1474], 'polynucleotide': [1475], 'kinase': [1476, 1600], 'Western': [1500], 'Blot': [1501], 'Analysis—Proteins': [1502], 'separated': [1508, 3007], 'SDS-PAGE': [1510], 'transferred': [1512], 'polyvinylidene': [1515], 'difluoride': [1516], 'membrane.': [1517], 'membrane': [1519, 1545], 'probed': [1521], 'rabbit': [1523], 'polyclonal': [1524], 'antibody': [1525, 1827, 3723], 'against': [1526], 'Stat1,': [1527, 2481, 2881], 'phospho-Stat1': [1528, 1533], '(PY701)': [1529], '(Cell': [1530], 'Technology),': [1532], '(serine': [1534], '727),': [1535], 'phospho-Stat2': [1538], '(PY690)': [1539], '(Upstate': [1540], 'Biotechnology).': [1541], 'Following': [1542], 'hybridization,': [1543], 'washed': [1547], 'developed': [1549], 'chemiluminescence.': [1551], 'Transfections': [1552], 'Luciferase': [1554], 'Assay—Cells': [1555], '(293T)': [1556], 'transfected': [1558, 2298, 2312, 2355, 2864, 3073], 'FuGENE': [1560], '(Roche': [1561], 'Applied': [1562], 'Science)': [1563], 'μg': [1566], 'luciferase': [1571, 1754, 2276, 2308, 2327, 2337, 2358, 2870, 2907, 3080, 3087, 3988], 'reporter': [1572, 2277, 2359, 2871, 2919, 3081], 'plasmids.': [1573], 'plasmids': [1575], 'contain': [1576, 1949, 2785, 3056, 3865], 'three': [1578], 'copies': [1579, 1587], 'IRF-1': [1582, 2295, 2435, 2520, 2615, 2650, 2683, 2710, 2746, 3449], 'five': [1586], 'located': [1593], '5′': [1594], 'minimal': [1597], 'herpes': [1598], 'thymidine': [1599], '(12Kraus': [1602, 1658], 'T.A.': [1603, 1659], 'Lau': [1604, 1660], 'J.F.': [1605, 1661], 'Parisien': [1606, 1662], 'J.-P.': [1607, 1663], '278:': [1614, 1670, 3626], '13033-13038Abstract': [1615, 1671], '(82)': [1623, 1679], '13Pine': [1626], 'Canova': [1628], 'Schindler': [1630], 'EMBO': [1632], '1994;': [1634], '13:': [1635, 2178, 3023, 3197, 3896], '158-167Crossref': [1636], '(340)': [1639], 'Wild': [1642], 'type': [1643, 1870], '(FLAG-tagged)': [1645], '(hemagglutinin-tagged)': [1648], 'plasmid': [1651, 1721, 3051], 'DNA': [1652, 2411, 2976, 3611], 'included': [1654], 'transfections': [1657], '14Shimozaki': [1682], 'Nakajima': [1684], 'S.K.': [1685], 'Hirano': [1686], 'Nagata': [1688], '272:': [1694], '25184-25189Abstract': [1695], '(156)': [1703], 'Stop': [1706], 'codons': [1707, 3046], 'amino': [1709, 2983, 2998, 3010, 3064, 3112, 3153, 3831, 3848, 3862], 'acids': [1710, 2984, 2999, 3011, 3065, 3113, 3154, 3832, 3849, 3863], '107,': [1711, 3060], '217,': [1712, 3061], '327': [1714], 'introduced': [1716, 3044], 'into': [1717, 2299, 3074], 'Stratagene': [1724], '(La': [1725], 'Jolla,': [1726], 'CA)': [1727], 'QuikChange': [1728], 'site-directed': [1729], 'mutagenesis': [1730], 'kit.': [1731], 'overnight': [1733], '37': [1736], '°C,': [1737], 'left': [1740], 'untreated': [1741, 2763, 3452], 'stimulated': [1743, 2303], '5': [1747], 'h.': [1748, 1897], 'lysates': [1750], 'prepared,': [1752, 2905], 'measured': [1757], 'normalized': [1759], 'total': [1761], 'protein': [1762, 3132, 3157], 'extracts.': [1765], 'Chromatin': [1766, 3202], 'Immunoprecipitation': [1767], '(ChIP)-PCR—ChIP': [1768], 'Sakamoto': [1775], 'et': [1776, 3504, 3883], 'al.': [1777, 3505, 3884], 'antisera': [1820, 3803], 'purchased': [1822], 'Santa': [1824, 3014, 3188, 3887], 'Cruz.': [1825], 'generated': [1829], 'rabbits': [1831], '(15Larner': [1835], 'David': [1837], 'G.M.': [1840], 'Webb': [1845], 'D.A.S.': [1846], 'Sweitzer': [1847], 'S.M.': [1848], 'Petricoin': [1849, 2135], 'III,': [1850, 2136], 'Science.': [1854, 2146], '1993;': [1855, 2177, 3022, 3196, 3895], '261:': [1856], '1730-1733Crossref': [1857], '(315)': [1860], 'IFN-induced': [1872], 'primary': [1877], 'immortalized': [1878], 'human': [1879], 'presence': [1886, 1911, 2058, 2464, 3100, 3742], '(1000': [1893], 'units/ml)': [1894], 'isolated,': [1900], 'RNase': [1902, 1992], 'probe': [1908, 2233], 'ISG56,': [1914, 1944], 'ISG15,': [1916, 1943], '6–16': [1918, 2009], 'RNAs.': [1919], 'Actin': [1920], 'analyzed': [1922, 2093], 'same': [1925, 3317], 'samples': [1926], 'internal': [1929], 'control': [1930, 2491], '(Fig.': [1931, 2069, 2073, 2209, 2234, 2245, 2316, 2521, 2602, 2617, 2641, 2672, 2696, 2885, 2921, 2933, 2965, 3105, 3440, 3859], '1A).': [1932], 'Incubation': [1933, 2185, 2911], 'IFNβ-induced': [1939], '6–16,': [1946], 'all': [1948, 2378, 3172, 3319], 'inhibitor': [1958, 3858], 'did': [1959, 2732, 2749, 3733], 'significantly': [1961], 'affect': [1962], 'induction': [1963, 2333], 'element.': [1972], 'relative': [1974], 'degree': [1975], 'various': [1980, 3239], 'ISGs': [1981, 1998], 'right': [1989], 'assay.': [1994], 'contained': [2000], 'somewhat': [2004], 'variable': [2005], 'being': [2010, 2258], 'less': [2011], 'than': [2013, 2330], 'ISG56.': [2016], 'determine': [2018, 2250, 2424, 2845, 3029], 'whether': [2019, 2251, 2425, 2846, 3706], 'alters': [2025, 3711], 'ability': [2035, 2408, 2632, 2808, 3608, 3683], 'DNA,': [2038, 2114], 'immunoblots': [2042, 2095], 'phospho-specific': [2044, 2097], 'antibodies': [2045], 'electrophoretic': [2047, 2216], 'mobility': [2048, 2217], 'shift': [2049, 2218], 'assays.': [2050, 2278, 2450], '30': [2064, 2460], '1B)': [2070], '1C)': [2074], 'prepared.': [2077], 'serine': [2088, 2116, 2205], 'antibodies.': [2098], 'Tyrosine': [2099], 'them': [2108], 'dimerize': [2110], 'whereas': [2115, 2954, 3147, 3483, 3842], 'Stats': [2120, 2429], 'including': [2121], '(but': [2123], 'Stat2)': [2125], 'maximal': [2130], 'transactivation': [2131], '(16David': [2133], 'Benjamin': [2138], 'Pine': [2140], 'Weber': [2142], 'M.J.': [2143], '1995;': [2147], '269:': [2148], '1721-1723Crossref': [2149], '(529)': [2152], '17Zhang': [2155], 'Wagner': [2157], 'B.J.': [2158], 'Ehrenman': [2159], 'Schaefer': [2161, 2563], 'A.W.': [2162], 'De': [2163], 'Maria': [2164, 3015, 3189, 3888], 'C.T.': [2165], 'Crater': [2166], 'DeHaven': [2168], 'Long': [2170], 'Brewer': [2172], '7652Crossref': [2179], '(497)': [2182], 'had': [2190, 2627, 2937], 'no': [2191, 2628, 2938, 3426], 'effect': [2192, 2629, 2939, 3427], '727': [2206], '1B).': [2210], 'findings': [2212, 3578], 'confirmed': [2214], 'analyze': [2221], '(Stat1,': [2226, 2854], 'IRF9)': [2229, 2857], '1C,': [2235, 2246], 'upper': [2236, 2935, 2967], 'panel)': [2237, 2936], 'lower': [2247], 'panel).': [2248], 'exerted': [2259], 'opposed': [2266], 'another': [2268], 'promoter,': [2273, 2684, 3719], 'Reporter': [2279], 'constructs': [2280], '293T': [2300, 2865, 3075], 'cells.': [2301, 2764], 'ISRE-': [2305], 'GAS-dependent': [2307], 'activities': [2309], 'reporters': [2315], '2).': [2317, 2622], 'Although': [2318, 2399, 3591, 3861], 'ISG54-ISRE': [2326], '80%,': [2331], 'IRF-1-GAS': [2336], 'Similar': [2348], 'observed': [2351], '(data': [2368, 3751], 'shown).': [2370, 3753], 'imply': [2373], 'directed': [2385], 'toward': [2386], 'elements': [2392], 'promoters': [2395, 2436, 2516, 3423, 3491, 3542], 'ISRE-containing': [2397, 3490], 'wanted': [2422], 'inhibitor.': [2442, 3344], 'address': [2444], 'issue,': [2446], 'ChIP': [2449, 3727], 'without': [2457, 2895, 3096], 'min': [2461], 'fixed': [2471], 'formaldehyde,': [2473], 'isolated': [2477], 'immunoprecipitated': [2479], 'II-specific': [2487], 'antiserum.': [2488], 'As': [2489], 'nonspecific': [2493], 'background,': [2494], 'precipitated': [2498], 'antiserum': [2500], 'recognizes': [2502], 'β-actin.': [2503], 'Immunoprecipitated': [2504], 'subject': [2508], 'PCR': [2510], 'primers': [2512], '3)': [2522, 2654], '18Yang': [2559], 'Henriksen': [2561], 'M.A.': [2562], 'O.': [2564], 'Zakharova': [2565], '277:': [2574, 3656], '13455-13462Abstract': [2575], '(67)': [2583], 'induced': [2590], '3A,': [2603, 2673], 'lanes': [2604, 2619, 2643, 2674, 2698, 2969], '1,': [2605], '2,': [2606, 2644], '4,': [2607], '5)': [2609], '3B,': [2618, 2642, 2697], '3,': [2645], '5,': [2646], '6)': [2648], '(lanes': [2651, 2946], 'striking': [2657], 'contrast,': [2658], 'completely': [2660, 2958, 3850], '7–9).': [2675], 'constitutively': [2679], 'associates': [2680, 2989], 'modestly': [2689], '4–6).': [2699], 'slightly': [2701], 'IFNβ-treated': [2713], 'variable,': [2716], 'reversal': [2720], 'importantly,': [2730], 'IFNα/β-enhanced': [2738], 'gene.': [2747, 2819], 'We': [2748, 3732, 3780, 3976], 'observe': [2751, 3735], 'any': [2752, 2847], 'recruitment': [2774, 3247, 3484, 3817], 'ISRE.': [2787], 'per': [2799], 'se': [2800], 'clearly': [2802, 3296], 'related': [2805], 'induce': [2812], 'affects': [2826, 3681], 'context': [2838, 3135], 'unclear.': [2843], 'known': [2850], 'components': [2851], 'might': [2858], '(see': [2872, 3696], 'Fig.': [2873, 3084, 3697], '2)': [2874], 'cDNA': [2876, 3167], 'vectors': [2878], 'encode': [2880], '4).': [2886, 2926], '24': [2887], 'h': [2888], 'post-transfection': [2889], '6': [2900], 'h,': [2901], 'assayed.': [2910], '4A,': [2922, 2934], 'lane': [2923], '3': [2924], 'versus': [2925, 2948, 2952], 'Co-expression': [2927], '7': [2947, 2970], '8': [2949], '11': [2951], '12),': [2953], 'reversed': [2959, 3141, 3159], '4B,': [2966, 3085], 'panel,': [2968], '8).': [2972], 'contains': [2974], 'domain': [2978, 2987, 3129, 3175, 3869, 3940, 3950], 'N-terminal': [2981, 3059, 3110, 3829], '127': [2982], '160': [2997], 'C': [3002, 3972], 'terminus.': [3003], '100': [3009], '(19Veals': [3012, 3186, 3885], 'S.A.': [3013, 3187, 3886], '196-206Crossref': [3024, 3198, 3897], 'reverse': [3037, 3118], 'stop': [3045], 'generate': [3053], 'proteins': [3054], '326': [3063, 3152, 3847], 'full-length': [3068], 'protein.': [3069], 'cDNAs': [3071], 'determined': [3090], '4C).': [3106, 3860], 'Expression': [3107], '107': [3111], 'failed': [3116], 'linker': [3128], 'N': [3138], 'terminus': [3139, 3973], 'partially': [3140, 3347, 3835], 'first': [3151, 3846], 'fully': [3158], 'latter': [3166], 'expresses': [3168], 'interaction': [3181, 3787], 'documented': [3206], 'correlate': [3208], 'Covalent': [3213], 'modifications': [3214], 'phosphorylation,': [3220], 'access': [3229], 'Acetylation': [3241], 'via': [3251], 'implicated': [3257], 'important': [3260], 'event': [3261, 3775], '(5Paulson': [3270], 'Results': [3291], 'presented': [3292], 'report': [3295], 'indicate': [3297], 'IFNβ-mediated': [3304], 'ISRE-dependent': [3307, 3575], 'ISRE-activated': [3320], 'least': [3324], '(IRF-1)': [3330], 'substantiate': [3348], 'those': [3349, 3500], 'recently': [3350], 'reported': [3351, 3501], 'Nusinzon': [3353], '(20Nusinzon': [3356, 3552], 'I.': [3357, 3553, 3651], '100:': [3367, 3563], '14742-14747Crossref': [3368, 3564], '(236)': [3371, 3567], 'results,': [3379], 'find': [3381], 'Our': [3398], 'provide': [3401], 'convincing': [3402], 'evidence': [3403], 'correlates': [3410], 'potential': [3413, 3964], 'recruiting': [3416], '3).': [3441], 'associated': [3446, 3472], 'cells,': [3453], 'disrupted': [3459], 'observation': [3463], 'suggests': [3464], 'independent': [3477], 'HDACs,': [3482], 'activity.': [3494], 'Rascle': [3503], 'interleukin-3-stimulated': [3524], 'rate': [3533], 'dissociation': [3535], 'sensitive': [3544], 'implicate': [3579], 'critical': [3581], 'mediating': [3586], 'previous': [3592], 'studies': [3593], 'indicated': [3595], 'IRF': [3598], 'members': [3600], 'acetylation': [3605, 3736], '(21Masumi': [3612], 'Yamakawa': [3614], 'Y.': [3615], 'Fukazawa': [3616], 'Ozato': [3618], 'Komuro': [3620], '25401-25407Abstract': [3627], '(45)': [3635], '22Caillaud': [3638], 'Prakash': [3640], 'Masumi': [3644], 'Hovamessian': [3646], 'A.G.': [3647], 'Marie': [3650], '49417-49421Abstract': [3657], '(66)': [3665], 'support': [3672], 'notion': [3674], 'ISRE-binding': [3689], '1).': [3698], 'it': [3700, 3936], 'possible': [3703], 'because': [3720], 'available.': [3731], 'Therefore,': [3754], 'substrate': [3756], 'permits': [3760], 'remain': [3776], 'determined.': [3779], 'unable': [3783], 'detect': [3785], 'between': [3788], 'immunoprecipitations': [3795], 'suggesting,': [3804], 'proving,': [3807], 'direct.': [3820], 'It': [3821], 'notable': [3823], 'only': [3827], '217': [3830], '1–326': [3864], 'part': [3866], 'IRF9,': [3878], 'Veals': [3882], 'Scholar)': [3900], 'truncated': [3905], 'version': [3906], 'fact': [3917], 'inhibit': [3926], 'formation': [3927], 'combined': [3930], 'truncation': [3933], 'studies,': [3934], 'makes': [3935], 'likely': [3937], 'needed': [3951], 'Studies': [3957], 'progress': [3960], 'identify': [3962], 'thank': [3977], 'Dr.': [3978], 'Curt': [3979], 'providing': [3982], 'us': [3983], 'construct.': [3989]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2066079888', 'counts_by_year': [{'year': 2024, 'cited_by_count': 2}, {'year': 2023, 'cited_by_count': 1}, {'year': 2022, 'cited_by_count': 4}, {'year': 2021, 'cited_by_count': 4}, {'year': 2020, 'cited_by_count': 2}, {'year': 2019, 'cited_by_count': 6}, {'year': 2018, 'cited_by_count': 5}, {'year': 2017, 'cited_by_count': 5}, {'year': 2016, 'cited_by_count': 7}, {'year': 2015, 'cited_by_count': 1}, {'year': 2014, 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