Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2066012394', 'doi': 'https://doi.org/10.1002/lt.21310', 'title': 'Safety and efficacy of combined use of sildenafil, bosentan, and iloprost before and after liver transplantation in severe portopulmonary hypertension', 'display_name': 'Safety and efficacy of combined use of sildenafil, bosentan, and iloprost before and after liver transplantation in severe portopulmonary hypertension', 'publication_year': 2008, 'publication_date': '2008-02-27', 'ids': {'openalex': 'https://openalex.org/W2066012394', 'doi': 'https://doi.org/10.1002/lt.21310', 'mag': '2066012394', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/18306330'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1002/lt.21310', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S205547219', 'display_name': 'Liver Transplantation', 'issn_l': '1527-6465', 'issn': ['1527-6465', '1527-6473'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315671', 'host_organization_name': 'Lippincott Williams & Wilkins', 'host_organization_lineage': ['https://openalex.org/P4310315671', 'https://openalex.org/P4310318547'], 'host_organization_lineage_names': ['Lippincott Williams & Wilkins', 'Wolters Kluwer'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5026695304', 'display_name': 'Mark Austin', 'orcid': 'https://orcid.org/0000-0003-4943-7265'}, 'institutions': [{'id': 'https://openalex.org/I4210153400', 'display_name': "King's College Hospital", 'ror': 'https://ror.org/044nptt90', 'country_code': 'GB', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210111135', 'https://openalex.org/I4210153400']}], 'countries': ['GB'], 'is_corresponding': True, 'raw_author_name': 'Mark J. Austin', 'raw_affiliation_strings': ["Institute of Liver Studies, King's College Hospital, London, England"], 'affiliations': [{'raw_affiliation_string': "Institute of Liver Studies, King's College Hospital, London, England", 'institution_ids': ['https://openalex.org/I4210153400']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5057499553', 'display_name': 'Neil McDougall', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I2802509250', 'display_name': 'Royal Victoria Eye and Ear Hospital', 'ror': 'https://ror.org/03z0mke78', 'country_code': 'IE', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2802509250']}], 'countries': ['IE'], 'is_corresponding': True, 'raw_author_name': 'Neil I. McDougall', 'raw_affiliation_strings': ['Royal Victoria Hospital, Belfast, Northern Ireland'], 'affiliations': [{'raw_affiliation_string': 'Royal Victoria Hospital, Belfast, Northern Ireland', 'institution_ids': ['https://openalex.org/I2802509250']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5009574999', 'display_name': 'Julia Wendon', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210153400', 'display_name': "King's College Hospital", 'ror': 'https://ror.org/044nptt90', 'country_code': 'GB', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210111135', 'https://openalex.org/I4210153400']}], 'countries': ['GB'], 'is_corresponding': True, 'raw_author_name': 'Julia A. Wendon', 'raw_affiliation_strings': ["Institute of Liver Studies, King's College Hospital, London, England"], 'affiliations': [{'raw_affiliation_string': "Institute of Liver Studies, King's College Hospital, London, England", 'institution_ids': ['https://openalex.org/I4210153400']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5075354259', 'display_name': 'Elizabeth Sizer', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210153400', 'display_name': "King's College Hospital", 'ror': 'https://ror.org/044nptt90', 'country_code': 'GB', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210111135', 'https://openalex.org/I4210153400']}], 'countries': ['GB'], 'is_corresponding': True, 'raw_author_name': 'Elizabeth Sizer', 'raw_affiliation_strings': ["Institute of Liver Studies, King's College Hospital, London, England"], 'affiliations': [{'raw_affiliation_string': "Institute of Liver Studies, King's College Hospital, London, England", 'institution_ids': ['https://openalex.org/I4210153400']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5062238961', 'display_name': 'A. S. Knisely', 'orcid': 'https://orcid.org/0000-0002-9173-539X'}, 'institutions': [{'id': 'https://openalex.org/I4210153400', 'display_name': "King's College Hospital", 'ror': 'https://ror.org/044nptt90', 'country_code': 'GB', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210111135', 'https://openalex.org/I4210153400']}], 'countries': ['GB'], 'is_corresponding': True, 'raw_author_name': 'Alex S. Knisely', 'raw_affiliation_strings': ["Institute of Liver Studies, King's College Hospital, London, England"], 'affiliations': [{'raw_affiliation_string': "Institute of Liver Studies, King's College Hospital, London, England", 'institution_ids': ['https://openalex.org/I4210153400']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5025174063', 'display_name': 'Mohammed Rela', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210153400', 'display_name': "King's College Hospital", 'ror': 'https://ror.org/044nptt90', 'country_code': 'GB', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210111135', 'https://openalex.org/I4210153400']}], 'countries': ['GB'], 'is_corresponding': True, 'raw_author_name': 'Mohammed Rela', 'raw_affiliation_strings': ["Institute of Liver Studies, King's College Hospital, London, England"], 'affiliations': [{'raw_affiliation_string': "Institute of Liver Studies, King's College Hospital, London, England", 'institution_ids': ['https://openalex.org/I4210153400']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5069657188', 'display_name': 'Carol J. Wilson', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I2802509250', 'display_name': 'Royal Victoria Eye and Ear Hospital', 'ror': 'https://ror.org/03z0mke78', 'country_code': 'IE', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2802509250']}], 'countries': ['IE'], 'is_corresponding': True, 'raw_author_name': 'Carol Wilson', 'raw_affiliation_strings': ['Royal Victoria Hospital, Belfast, Northern Ireland'], 'affiliations': [{'raw_affiliation_string': 'Royal Victoria Hospital, Belfast, Northern Ireland', 'institution_ids': ['https://openalex.org/I2802509250']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5005740709', 'display_name': 'M. E. Callender', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I2802509250', 'display_name': 'Royal Victoria Eye and Ear Hospital', 'ror': 'https://ror.org/03z0mke78', 'country_code': 'IE', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2802509250']}], 'countries': ['IE'], 'is_corresponding': True, 'raw_author_name': 'Michael E. Callender', 'raw_affiliation_strings': ['Royal Victoria Hospital, Belfast, Northern Ireland'], 'affiliations': [{'raw_affiliation_string': 'Royal Victoria Hospital, Belfast, Northern Ireland', 'institution_ids': ['https://openalex.org/I2802509250']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5102087388', 'display_name': 'John G. O’Grady', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210153400', 'display_name': "King's College Hospital", 'ror': 'https://ror.org/044nptt90', 'country_code': 'GB', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210111135', 'https://openalex.org/I4210153400']}], 'countries': ['GB'], 'is_corresponding': True, 'raw_author_name': "John G. O'Grady", 'raw_affiliation_strings': ["Institute of Liver Studies, King's College Hospital, London, England"], 'affiliations': [{'raw_affiliation_string': "Institute of Liver Studies, King's College Hospital, London, England", 'institution_ids': ['https://openalex.org/I4210153400']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5013018249', 'display_name': 'Michael A. Heneghan', 'orcid': 'https://orcid.org/0000-0002-5441-9064'}, 'institutions': [{'id': 'https://openalex.org/I4210153400', 'display_name': "King's College Hospital", 'ror': 'https://ror.org/044nptt90', 'country_code': 'GB', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210111135', 'https://openalex.org/I4210153400']}], 'countries': ['GB'], 'is_corresponding': True, 'raw_author_name': 'Michael A. Heneghan', 'raw_affiliation_strings': ["Institute of Liver Studies, King's College Hospital, London, England"], 'affiliations': [{'raw_affiliation_string': "Institute of Liver Studies, King's College Hospital, London, England", 'institution_ids': ['https://openalex.org/I4210153400']}]}], 'countries_distinct_count': 2, 'institutions_distinct_count': 2, 'corresponding_author_ids': ['https://openalex.org/A5026695304', 'https://openalex.org/A5057499553', 'https://openalex.org/A5009574999', 'https://openalex.org/A5075354259', 'https://openalex.org/A5062238961', 'https://openalex.org/A5025174063', 'https://openalex.org/A5069657188', 'https://openalex.org/A5005740709', 'https://openalex.org/A5102087388', 'https://openalex.org/A5013018249'], 'corresponding_institution_ids': ['https://openalex.org/I4210153400', 'https://openalex.org/I2802509250', 'https://openalex.org/I4210153400', 'https://openalex.org/I4210153400', 'https://openalex.org/I4210153400', 'https://openalex.org/I4210153400', 'https://openalex.org/I2802509250', 'https://openalex.org/I2802509250', 'https://openalex.org/I4210153400', 'https://openalex.org/I4210153400'], 'apc_list': None, 'apc_paid': None, 'fwci': 9.684, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 103, 'citation_normalized_percentile': {'value': 0.999962, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 97, 'max': 98}, 'biblio': {'volume': '14', 'issue': '3', 'first_page': '287', 'last_page': '291'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10728', 'display_name': 'Diagnosis and Treatment of Pulmonary Hypertension', 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/2740', 'display_name': 'Pulmonary and Respiratory Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10728', 'display_name': 'Diagnosis and Treatment of Pulmonary Hypertension', 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/2740', 'display_name': 'Pulmonary and Respiratory Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10337', 'display_name': 'Liver Cirrhosis and Associated Complications', 'score': 0.9997, 'subfield': {'id': 'https://openalex.org/subfields/2721', 'display_name': 'Hepatology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10999', 'display_name': 'Liver Transplantation and Graft Survival Analysis', 'score': 0.9979, 'subfield': {'id': 'https://openalex.org/subfields/2746', 'display_name': 'Surgery'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/portopulmonary-hypertension', 'display_name': 'Portopulmonary hypertension', 'score': 0.97846675}, {'id': 'https://openalex.org/keywords/iloprost', 'display_name': 'Iloprost', 'score': 0.60093784}, {'id': 'https://openalex.org/keywords/pulmonary-hypertension', 'display_name': 'Pulmonary Hypertension', 'score': 0.574571}, {'id': 'https://openalex.org/keywords/liver-transplantation', 'display_name': 'Liver Transplantation', 'score': 0.539091}, {'id': 'https://openalex.org/keywords/portal-hypertension', 'display_name': 'Portal Hypertension', 'score': 0.531386}], 'concepts': [{'id': 'https://openalex.org/C2777728312', 'wikidata': 'https://www.wikidata.org/wiki/Q7232210', 'display_name': 'Portopulmonary hypertension', 'level': 4, 'score': 0.97846675}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.9503403}, {'id': 'https://openalex.org/C2781109936', 'wikidata': 'https://www.wikidata.org/wiki/Q419769', 'display_name': 'Bosentan', 'level': 4, 'score': 0.9013912}, {'id': 'https://openalex.org/C2779609443', 'wikidata': 'https://www.wikidata.org/wiki/Q1368191', 'display_name': 'Liver transplantation', 'level': 3, 'score': 0.8315255}, {'id': 'https://openalex.org/C2776768464', 'wikidata': 'https://www.wikidata.org/wiki/Q191521', 'display_name': 'Sildenafil', 'level': 2, 'score': 0.72902215}, {'id': 'https://openalex.org/C2781103887', 'wikidata': 'https://www.wikidata.org/wiki/Q20817139', 'display_name': 'Iloprost', 'level': 3, 'score': 0.60093784}, {'id': 'https://openalex.org/C2911091166', 'wikidata': 'https://www.wikidata.org/wiki/Q106419912', 'display_name': 'Transplantation', 'level': 2, 'score': 0.41787106}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.40143642}, {'id': 'https://openalex.org/C164705383', 'wikidata': 'https://www.wikidata.org/wiki/Q10379', 'display_name': 'Cardiology', 'level': 1, 'score': 0.3914566}, {'id': 'https://openalex.org/C2781128415', 'wikidata': 'https://www.wikidata.org/wiki/Q412050', 'display_name': 'Prostacyclin', 'level': 2, 'score': 0.17014372}, {'id': 'https://openalex.org/C144980905', 'wikidata': 'https://www.wikidata.org/wiki/Q24721308', 'display_name': 'Endothelin receptor', 'level': 3, 'score': 0.08206776}, {'id': 'https://openalex.org/C170493617', 'wikidata': 'https://www.wikidata.org/wiki/Q208467', 'display_name': 'Receptor', 'level': 2, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D006975', 'descriptor_name': 'Hypertension, Portal', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': True}, {'descriptor_ui': 'D006976', 'descriptor_name': 'Hypertension, Pulmonary', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': True}, {'descriptor_ui': 'D016285', 'descriptor_name': 'Iloprost', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': True}, {'descriptor_ui': 'D016031', 'descriptor_name': 'Liver Transplantation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D010879', 'descriptor_name': 'Piperazines', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': True}, {'descriptor_ui': 'D013449', 'descriptor_name': 'Sulfonamides', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': True}, {'descriptor_ui': 'D013450', 'descriptor_name': 'Sulfones', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': True}, {'descriptor_ui': 'D014665', 'descriptor_name': 'Vasodilator Agents', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': True}, {'descriptor_ui': 'D000328', 'descriptor_name': 'Adult', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001794', 'descriptor_name': 'Blood Pressure', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001794', 'descriptor_name': 'Blood Pressure', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}, {'descriptor_ui': 'D001794', 'descriptor_name': 'Blood Pressure', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D000077300', 'descriptor_name': 'Bosentan', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004305', 'descriptor_name': 'Dose-Response Relationship, Drug', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004359', 'descriptor_name': 'Drug Therapy, Combination', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D064420', 'descriptor_name': 'Drug-Related Side Effects and Adverse Reactions', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006975', 'descriptor_name': 'Hypertension, Portal', 'qualifier_ui': 'Q000503', 'qualifier_name': 'physiopathology', 'is_major_topic': False}, {'descriptor_ui': 'D006975', 'descriptor_name': 'Hypertension, Portal', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006976', 'descriptor_name': 'Hypertension, Pulmonary', 'qualifier_ui': 'Q000503', 'qualifier_name': 'physiopathology', 'is_major_topic': False}, {'descriptor_ui': 'D006976', 'descriptor_name': 'Hypertension, Pulmonary', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016285', 'descriptor_name': 'Iloprost', 'qualifier_ui': 'Q000009', 'qualifier_name': 'adverse effects', 'is_major_topic': False}, {'descriptor_ui': 'D016285', 'descriptor_name': 'Iloprost', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008107', 'descriptor_name': 'Liver Diseases', 'qualifier_ui': 'Q000503', 'qualifier_name': 'physiopathology', 'is_major_topic': False}, {'descriptor_ui': 'D008107', 'descriptor_name': 'Liver Diseases', 'qualifier_ui': 'Q000601', 'qualifier_name': 'surgery', 'is_major_topic': False}, {'descriptor_ui': 'D008107', 'descriptor_name': 'Liver Diseases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010879', 'descriptor_name': 'Piperazines', 'qualifier_ui': 'Q000009', 'qualifier_name': 'adverse effects', 'is_major_topic': False}, {'descriptor_ui': 'D010879', 'descriptor_name': 'Piperazines', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011651', 'descriptor_name': 'Pulmonary Artery', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011651', 'descriptor_name': 'Pulmonary Artery', 'qualifier_ui': 'Q000503', 'qualifier_name': 'physiopathology', 'is_major_topic': False}, {'descriptor_ui': 'D011687', 'descriptor_name': 'Purines', 'qualifier_ui': 'Q000009', 'qualifier_name': 'adverse effects', 'is_major_topic': False}, {'descriptor_ui': 'D011687', 'descriptor_name': 'Purines', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': False}, {'descriptor_ui': 'D011687', 'descriptor_name': 'Purines', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012720', 'descriptor_name': 'Severity of Illness Index', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000068677', 'descriptor_name': 'Sildenafil Citrate', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013449', 'descriptor_name': 'Sulfonamides', 'qualifier_ui': 'Q000009', 'qualifier_name': 'adverse effects', 'is_major_topic': False}, {'descriptor_ui': 'D013449', 'descriptor_name': 'Sulfonamides', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013450', 'descriptor_name': 'Sulfones', 'qualifier_ui': 'Q000009', 'qualifier_name': 'adverse effects', 'is_major_topic': False}, {'descriptor_ui': 'D013450', 'descriptor_name': 'Sulfones', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016896', 'descriptor_name': 'Treatment Outcome', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014665', 'descriptor_name': 'Vasodilator Agents', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1002/lt.21310', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S205547219', 'display_name': 'Liver Transplantation', 'issn_l': '1527-6465', 'issn': ['1527-6465', '1527-6473'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315671', 'host_organization_name': 'Lippincott Williams & Wilkins', 'host_organization_lineage': ['https://openalex.org/P4310315671', 'https://openalex.org/P4310318547'], 'host_organization_lineage_names': ['Lippincott Williams & Wilkins', 'Wolters Kluwer'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/18306330', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/3', 'score': 0.79, 'display_name': 'Good health and well-being'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 28, 'referenced_works': ['https://openalex.org/W1968173552', 'https://openalex.org/W1981316991', 'https://openalex.org/W1983963274', 'https://openalex.org/W1986098706', 'https://openalex.org/W1991109054', 'https://openalex.org/W2000059950', 'https://openalex.org/W2028429430', 'https://openalex.org/W2034232989', 'https://openalex.org/W2048443661', 'https://openalex.org/W2053640864', 'https://openalex.org/W2067113337', 'https://openalex.org/W2069727305', 'https://openalex.org/W2073730215', 'https://openalex.org/W2076812615', 'https://openalex.org/W2077671169', 'https://openalex.org/W2083622527', 'https://openalex.org/W2086658563', 'https://openalex.org/W2087102978', 'https://openalex.org/W2090659780', 'https://openalex.org/W2098361750', 'https://openalex.org/W2099410981', 'https://openalex.org/W2116152202', 'https://openalex.org/W2141898868', 'https://openalex.org/W2146493192', 'https://openalex.org/W2162036654', 'https://openalex.org/W2163821775', 'https://openalex.org/W2166356568', 'https://openalex.org/W2410992506'], 'related_works': ['https://openalex.org/W4293153681', 'https://openalex.org/W2413377568', 'https://openalex.org/W2329900744', 'https://openalex.org/W2294881929', 'https://openalex.org/W2141841707', 'https://openalex.org/W2087469627', 'https://openalex.org/W2075746894', 'https://openalex.org/W2029846056', 'https://openalex.org/W1959553344', 'https://openalex.org/W104329758'], 'abstract_inverted_index': {'Liver': [0, 38, 75, 93, 113, 131, 183, 206, 224, 250, 287, 305, 325, 343, 395, 418, 436, 551, 728, 3242, 3605, 3789], 'TransplantationVolume': [1], '14,': [2], 'Issue': [3], '3': [4, 1557, 1619, 1734, 3214], 'p.': [5], '287-291': [6, 4051], 'Original': [7], 'ArticlesFree': [8], 'Access': [9], 'Safety': [10], 'and': [11, 19, 22, 485, 489, 501, 508, 527, 557, 603, 610, 614, 637, 677, 706, 787, 824, 838, 842, 860, 884, 907, 926, 993, 1006, 1022, 1039, 1094, 1117, 1124, 1135, 1151, 1180, 1196, 1202, 1209, 1286, 1368, 1447, 1472, 1542, 1573, 1655, 1670, 1679, 1688, 1691, 1737, 1803, 1829, 1840, 1854, 1862, 1934, 1954, 1976, 2022, 2077, 2269, 2285, 2289, 2312, 2328, 2338, 2365, 2387, 2397, 2401, 2430, 2448, 2460, 2481, 2487, 2501, 2549, 2554, 2561, 2609, 2630, 2636, 2654, 2671, 2749, 2795, 2808, 2844, 2848, 2908, 2939, 3011, 3054, 3111, 3158, 3163, 3231, 3271, 3294, 3421, 3468, 3474, 3676, 3709, 3959, 3996, 4020, 4031], 'efficacy': [12], 'of': [13, 16, 37, 74, 92, 112, 130, 182, 205, 223, 249, 286, 304, 324, 342, 394, 417, 435, 487, 497, 510, 521, 607, 675, 681, 698, 743, 807, 853, 857, 862, 866, 873, 886, 888, 900, 970, 976, 987, 1035, 1045, 1091, 1157, 1166, 1216, 1231, 1237, 1269, 1291, 1302, 1310, 1342, 1365, 1375, 1449, 1503, 1514, 1516, 1570, 1686, 1689, 1706, 1719, 1754, 1769, 1781, 1790, 1799, 1909, 1940, 2075, 2239, 2282, 2326, 2479, 2491, 2518, 2530, 2536, 2543, 2585, 2592, 2645, 2702, 2706, 2741, 2752, 2828, 2835, 2863, 2876, 2886, 2894, 2905, 2915, 2942, 2949, 2958, 2991, 3004, 3008, 3046, 3057, 3083, 3109, 3139, 3160, 3173, 3192, 3211, 3236, 3251, 3282, 3303, 3310, 3314, 3327, 3349, 3380, 3410, 3434, 3447, 3457, 3487, 3518, 3551, 3582, 3625, 3634, 3666, 3687, 3707, 3717, 3731, 3746, 3767, 3799, 3843, 3866, 3877, 3891, 3937, 3948, 3974, 3985, 4005, 4022, 4043], 'combined': [14, 1787], 'use': [15, 2644, 2670, 2740, 2751, 2862, 2893, 2904, 3003], 'sildenafil,': [17, 609, 1471, 2284, 2655, 2907, 3010], 'bosentan,': [18, 1067, 2283, 2613, 2866, 3878, 3949], 'iloprost': [20, 1450, 1544, 1572, 1587, 1738, 1969, 2286], 'before': [21, 2267, 2288, 2295, 2830, 2981, 3052], 'after': [23, 1029, 1071, 1568, 1643, 1671, 1717, 1823, 1887, 1890, 2025, 2290, 2299, 2755, 2983, 3061, 3783, 3815], 'liver': [24, 749, 854, 1456, 1859, 2552, 2641, 2877, 3101, 3198, 3239, 3273, 3315, 3339, 3364, 3602], 'transplantation': [25, 552, 3365], 'in': [26, 546, 644, 710, 719, 722, 894, 939, 949, 967, 990, 1020, 1351, 1425, 1548, 1648, 1677, 1760, 1938, 2167, 2176, 2229, 2237, 2280, 2319, 2334, 2356, 2358, 2367, 2375, 2428, 2477, 2503, 2527, 2540, 2547, 2550, 2588, 2602, 2633, 2639, 2647, 2666, 2679, 2712, 2766, 2825, 2837, 2841, 2850, 2883, 2927, 2955, 2960, 2969, 2993, 3013, 3049, 3098, 3195, 3337, 3366, 3398, 3601, 3662, 3714, 3720, 3750, 3786, 3827, 3991, 4024], 'severe': [27, 581, 598, 693, 950, 973, 1003, 1080, 1531, 2961, 3017], 'portopulmonary': [28, 1467, 3164, 3193, 3232, 3508, 3572, 3787, 3992, 4029], 'hypertension†': [29], 'Mark': [30, 33, 242, 245], 'J.': [31, 34, 243, 246], 'Austin,': [32, 244], 'Austin': [35, 247], 'Institute': [36, 73, 91, 111, 129, 181, 204, 248, 285, 303, 323, 341, 393, 416], 'Studies,': [39, 76, 94, 114, 132, 184, 207, 225, 251, 288, 306, 326, 344, 396, 419, 437], "King's": [40, 77, 95, 115, 133, 185, 208, 226, 252, 289, 307, 327, 345, 397, 420, 438, 1478], 'College': [41, 78, 96, 116, 134, 186, 209, 227, 253, 290, 308, 328, 346, 398, 421, 439, 1479], 'Hospital,': [42, 58, 79, 97, 117, 135, 149, 166, 187, 210, 228, 254, 270, 291, 309, 329, 347, 361, 378, 399, 422, 440, 1480], 'London,': [43, 80, 98, 118, 136, 188, 211, 255, 292, 310, 330, 348, 400, 423], 'EnglandSearch': [44, 81, 99, 119, 137, 189, 256, 293, 311, 331, 349, 401], 'for': [45, 62, 82, 100, 120, 138, 153, 170, 190, 236, 257, 274, 294, 312, 332, 350, 365, 382, 402, 448, 616, 757, 957, 1068, 1084, 1359, 1609, 1884, 2046, 2612, 2628, 2821, 3073, 3197, 3507, 3538, 3571, 3923], 'more': [46, 63, 83, 101, 121, 139, 154, 171, 191, 237, 258, 275, 295, 313, 333, 351, 366, 383, 403, 449, 2047, 3422, 3442], 'papers': [47, 64, 84, 102, 122, 140, 155, 172, 192, 238, 259, 276, 296, 314, 334, 352, 367, 384, 404, 450], 'by': [48, 65, 85, 103, 123, 141, 156, 173, 193, 239, 260, 277, 297, 315, 335, 353, 368, 385, 405, 451, 568, 871, 985, 1698, 1844, 1894, 2390, 2455], 'this': [49, 66, 86, 104, 124, 142, 157, 174, 194, 240, 261, 278, 298, 316, 336, 354, 369, 386, 406, 452, 522, 686, 696, 952, 1051, 1583, 1998, 2273, 2320, 2494, 2596, 2648, 2767, 2822, 2851, 2895, 2928, 2970], 'authorNeil': [50, 262], 'I.': [51, 54, 263, 266], 'McDougall,': [52, 264], 'Neil': [53, 265], 'McDougall': [55, 267], 'Royal': [56, 147, 164, 268, 359, 376], 'Victoria': [57, 148, 165, 269, 360, 377], 'Belfast,': [59, 150, 167, 271, 362, 379], 'Northern': [60, 151, 168, 272, 363, 380], 'IrelandSearch': [61, 152, 169, 273, 364, 381], 'authorJulia': [67, 279], 'A.': [68, 71, 196, 201, 280, 283, 408, 413], 'Wendon,': [69, 281], 'Julia': [70, 282], 'Wendon': [72, 284], 'authorElizabeth': [87, 299], 'Sizer,': [88, 300], 'Elizabeth': [89, 301], 'Sizer': [90, 302], 'authorAlex': [105, 317], 'S.': [106, 109, 318, 321, 3850], 'Knisely,': [107, 319], 'Alex': [108, 320], 'Knisely': [110, 322], 'authorMohammed': [125, 337], 'Rela,': [126, 338], 'Mohammed': [127, 339], 'Rela': [128, 340], 'authorCarol': [143, 355], 'Wilson,': [144, 356], 'Carol': [145, 357], 'Wilson': [146, 358], 'authorMichael': [158, 195, 370, 407], 'E.': [159, 162, 371, 374], 'Callender,': [160, 372], 'Michael': [161, 200, 373, 412], 'Callender': [163, 375], 'authorJohn': [175, 387], 'G.': [176, 179, 388, 391], "O'Grady,": [177, 389], 'John': [178, 390], "O'Grady": [180, 392], 'Heneghan,': [197, 409], 'Corresponding': [198, 410], 'Author': [199, 411], 'Heneghan': [202, 414], '[email protected]': [203, 415], 'England': [212, 424], 'Telephone:': [213, 425], '44': [214, 219, 426, 431], '203': [215, 220, 427, 432], '299': [216, 221, 428, 433], '4952;': [217, 429], 'FAX:': [218, 430], '3167Institute': [222, 434], 'Denmark': [229, 441], 'Hill,': [230, 442], 'London': [231, 443], 'SE5': [232, 444], '9RS,': [233, 445], 'United': [234, 446], 'KingdomSearch': [235, 447], 'author': [241, 453], 'First': [454], 'published:': [455], '27': [456, 3977], 'February': [457], '2008': [458, 733], 'https://doi.org/10.1002/lt.21310Citations:': [459], '81': [460], '†': [461], 'See': [462], 'Editorial': [463], 'on': [464, 601, 622, 1063, 1181, 1497, 1528, 1832, 1964, 1968, 2039, 2053, 2257, 2393, 2421, 2763, 2780, 2977, 3135, 3424, 3472, 3954], 'Page': [465], '270': [466], 'AboutSectionsPDF': [467], 'ToolsRequest': [468], 'permissionExport': [469], 'citationAdd': [470], 'to': [471, 493, 516, 561, 632, 646, 659, 668, 704, 879, 922, 943, 1050, 1373, 1432, 1597, 1613, 1638, 1726, 1745, 1776, 1808, 1813, 1898, 1906, 1916, 1949, 2005, 2070, 2248, 2341, 2409, 2437, 2558, 2590, 2683, 2717, 2736, 2747, 2772, 2785, 2791, 2880, 2900, 2946, 2972, 3041, 3068, 3086, 3114, 3125, 3142, 3370, 3659, 3754, 3820], 'favoritesTrack': [472], 'citation': [473], 'ShareShare': [474], 'Give': [475], 'accessShare': [476, 479], 'full': [477], 'text': [478], 'full-text': [480, 495, 519], 'accessPlease': [481], 'review': [482], 'our': [483], 'Terms': [484, 507], 'Conditions': [486, 509], 'Use': [488, 3984], 'check': [490], 'box': [491], 'below': [492, 515, 2510, 2693], 'share': [494, 517], 'version': [496, 520], 'article.I': [498], 'have': [499, 830, 927, 2371, 2404, 2418, 2443, 2775, 2800, 2911, 2964, 3079], 'read': [500], 'accept': [502], 'the': [503, 513, 688, 711, 723, 741, 889, 898, 908, 991, 1031, 1046, 1232, 1300, 1308, 1501, 1571, 1591, 1699, 1960, 2011, 2013, 2054, 2073, 2277, 2323, 2359, 2398, 2485, 2488, 2511, 2528, 2574, 2700, 2725, 2729, 2805, 2812, 2874, 2884, 2892, 2913, 2940, 2943, 2947, 2956, 2967, 3001, 3055, 3100, 3137, 3237, 3272, 3673, 3710, 3715, 3721, 3914], 'Wiley': [504, 3208, 3248, 3346, 3431, 3454, 3612, 3728, 3796, 3934, 3971], 'Online': [505, 3209, 3249, 3347, 3432, 3455, 3613, 3729, 3797, 3935, 3972], 'Library': [506], 'UseShareable': [511], 'LinkUse': [512], 'link': [514], 'a': [518, 533, 542, 569, 595, 641, 702, 760, 779, 903, 933, 960, 968, 999, 1130, 1200, 1258, 1340, 1426, 1511, 1624, 1750, 1777, 1907, 1928, 2040, 2065, 2165, 2260, 2344, 2379, 2603, 2620, 2674, 2994, 3005, 3014, 3038, 3200, 3234, 3445, 3623, 3852, 3879, 3920, 3986, 3994], 'article': [523], 'with': [524, 548, 563, 580, 597, 679, 692, 748, 811, 828, 941, 959, 972, 981, 1001, 1079, 1102, 1129, 1169, 1315, 1329, 1348, 1582, 1665, 1681, 1749, 1774, 1827, 1851, 2027, 2232, 2413, 2499, 2583, 2595, 2615, 2699, 2860, 2922, 2930, 3016, 3022, 3368, 3401, 3823, 3830, 4028], 'your': [525], 'friends': [526], 'colleagues.': [528], 'Learn': [529], 'more.Copy': [530], 'URL': [531], 'Share': [532], 'linkShare': [534], 'onFacebookTwitterLinked': [535], 'InRedditWechat': [536], 'Abstract': [537], 'Portopulmonary': [538, 735, 3269, 3292, 3396, 3416, 3621], 'hypertension': [539, 736, 746, 798, 809, 1099, 1168, 3194, 3270, 3293, 3397, 3600, 4030], '(PPHTN)': [540, 737], 'represents': [541], 'constrictive': [543], 'pulmonary': [544, 571, 652, 744, 762, 790, 890, 1043, 1238, 1444, 1460, 1504, 1895, 2168, 2197, 2201, 2207, 2309, 2313, 2381, 2439, 2532, 2544, 2562, 2974, 3035, 3311, 3372, 3539, 3599, 3663, 3756, 3831], 'vasculopathy': [545], 'patients': [547, 562, 721, 940, 958, 971, 977, 2231, 3367, 3829], 'portal': [549, 752, 797, 808, 815, 858, 1008, 1098, 1104, 1167, 1185, 1836, 1864, 1867], 'hypertension.': [550, 1009, 3165, 3373, 3509, 3541, 3573, 3788, 3833], '(LT)': [553], 'may': [554, 716, 2417, 2482, 2581, 2910, 2951, 3088, 3095], 'be': [555, 2265, 2952, 2990, 3096], 'curative': [556], 'is': [558, 687, 738, 868, 936, 954, 2037, 2302, 2322, 2330, 2571, 2625, 2734, 2793, 2839, 2897, 3141], 'usually': [559, 589], 'restricted': [560], 'mild-to-moderate': [564], 'disease': [565, 582, 750, 1024, 1047, 1240, 1539, 3753], 'severity': [566, 852, 861], 'characterized': [567], 'mean': [570, 761, 1459], 'artery': [572, 763, 1445, 1461, 2169, 2198, 2202], 'pressure': [573, 764, 783, 1215, 1390, 1446, 1485, 1513, 1595, 1659, 1753, 1904, 1989, 2099, 2106, 2799], '(mPAP': [574, 583, 1324, 1533], '<': [575, 1275], '35': [576, 2121, 2146, 2718], 'mm': [577, 586, 630, 634, 648, 670, 768, 775, 785, 964, 1218, 1225, 1327, 1420, 1435, 1490, 1536, 1580, 1747, 1756, 1911, 1918, 1992, 2241, 2685, 2695, 2719], 'Hg).': [578, 1226, 1537], 'Patients': [579, 827], '>': [584, 766, 773, 962], '50': [585, 963, 1343, 1978, 2240], 'Hg)': [587, 1328, 1581, 2101, 2108, 2117, 2127], 'are': [588, 759, 844, 897, 915, 920, 1415, 2434, 2449, 2474, 2524, 2538, 2555, 2622, 3064], 'excluded': [590], 'from': [591, 628, 657, 1429, 1663, 1959, 1997, 2010, 2068, 2681, 2715, 3103, 3817], 'transplantation.': [592, 1073], 'We': [593, 997, 1057, 2963], 'describe': [594, 998, 2276, 3000], 'patient': [596, 691, 1000, 1356, 1817, 2014, 2823, 2937, 3015], 'PPHTN,': [599, 951, 974, 1466, 2548], 'initiated': [600, 2651], 'sequential': [602], 'ultimately': [604, 3143], 'combination': [605, 697, 1052, 1064, 1584, 1682, 2056, 2669, 2705, 2727, 3020, 3047, 3059, 3107], 'therapy': [606, 624, 639, 700, 989, 1012, 3007, 3048, 3060, 3094, 3108, 3537, 3570, 3785, 3822], 'prostacyclin,': [608, 1470], 'bosentan': [611, 1040, 1627, 1690, 1720, 1971, 2570, 2909, 3012, 3112, 3824, 3912, 4023], '(PSB)': [612], 'pretransplantation': [613], 'continued': [615, 638, 1807, 2055, 2739, 2861, 3058], '2': [617, 1069, 2049, 3176], 'years': [618, 1070, 2050], 'posttransplantation.': [619, 650], 'Peak': [620], 'mPAP': [621, 645, 666, 772, 961, 1021, 1401, 1577, 1605, 1652, 1678, 1743, 2115, 2236, 2263, 2505, 2680, 2713, 2781, 2794, 2829, 3051], 'PSB': [623, 682, 1791, 1833, 1872, 2646, 2707, 2743, 2985], 'was': [625, 1013, 1082, 1100, 1127, 1142, 1160, 1177, 1187, 1337, 1357, 1452, 1486, 1495, 1526, 1540, 1553, 1564, 1588, 1631, 1713, 1792, 1811, 1838, 1841, 1849, 1860, 1873, 1892, 1936, 1946, 1957, 2000, 2003, 2506, 2650, 2677, 3120], 'dramatically': [626, 2028], 'reduced': [627, 2507], '70': [629, 1535, 2119, 2682], 'Hg': [631, 635, 649, 671, 769, 776, 1219, 1436, 1748, 1757, 1919, 2686, 2696], '32': [633, 2110], 'pretransplantation,': [636], 'facilitated': [640], 'further': [642], 'fall': [643], '28': [647, 2123, 2124, 4008], 'The': [651, 664, 754, 803, 1042, 1355, 1560, 1576, 1611, 1673, 1786, 1816, 1835, 1857, 1994, 2162, 2565, 2606, 2643, 2689, 2704, 2817, 2832, 3043, 3105, 3155, 3705, 3909], 'vascular': [653, 791, 2208, 2306, 2310, 2975, 3312], 'resistance': [654, 792, 2209], 'index': [655, 793, 1765, 2560], 'fell': [656, 678, 1424, 1744], '604': [658, 2157], '291': [660], 'dyne': [661], 'second−1': [662], 'cm−5.': [663], 'perioperative': [665], 'rose': [667, 1905], '100': [669, 1217], 'following': [672, 979, 1870], 'an': [673, 788, 1210, 2225, 2235, 2245, 2253, 3667, 3950], 'episode': [674], 'sepsis': [676], 'optimization': [680, 986], 'therapy.': [683, 1834, 2986], 'In': [684, 1087, 1110, 2272, 2493, 2997], 'conclusion,': [685, 2998], 'first': [689], 'reported': [690, 1113], 'PPHTN': [694, 758, 812, 829, 867, 1005, 1081, 1323, 1532, 2301, 2838], 'using': [695, 1927], 'vasodilator': [699], 'as': [701, 708, 740, 834, 932, 1417, 1488, 1543, 1696, 2304, 2318, 2619, 2656], 'bridge': [703, 3040], 'LT': [705, 718, 931, 1085, 1360, 1669, 1820, 1891, 2222, 2268, 2618, 2748, 2959, 3053, 3062], 'then': [707, 1058, 1914], 'maintenance': [709, 2773], 'posttransplantation': [712, 982, 994, 2806], 'phase.': [713], 'This': [714, 2463, 2888, 3019], 'regimen': [715, 1789, 1926, 2849], 'enable': [717], 'similar': [720, 2461], 'future,': [724], 'without': [725, 801, 1108, 1172, 1267, 1758, 2292, 2617, 2867, 3116, 3123], 'long-term': [726, 2227, 2351, 2984, 3090], 'consequences.': [727], 'Transpl': [729, 3243, 3606, 3790], '14:287–291,': [730], '2008.': [731], '©': [732], 'AASLD.': [734], 'defined': [739], 'development': [742], 'arterial': [745, 1853, 2440, 2533, 2545, 3540, 3832], 'associated': [747, 810, 2842, 2919], 'or': [751, 800, 1241, 1763, 2178, 2180, 2296, 2516, 2616, 2782, 2982, 3076, 3825], 'hypertension.1': [753], 'diagnostic': [755], 'criteria': [756], '(mPAP)': [765, 1371], '25': [767, 1755, 2091, 3894], 'at': [770, 1339, 1477, 1875, 1990, 2708, 3028, 3033], 'rest,': [771], '30': [774, 2111], 'during': [777, 2811], 'exercise,': [778], 'normal': [780, 1464, 2045, 3087], 'capillary': [781, 2203], 'wedge': [782, 2204], '(<15': [784], 'Hg),': [786], 'elevated': [789, 2539, 3747], '(>240': [794], 'dyne/second/cm−5)': [795], 'alongside': [796, 1730, 2757], '(with': [799], 'cirrhosis).2-5': [802], 'recognized': [804], 'noncirrhotic': [805, 1007, 1861], 'causes': [806], 'include': [813], 'extrahepatic': [814], 'vein': [816, 1105, 1175, 1186, 1837], 'obstruction,': [817], 'congenital': [818, 3751], 'hepatic': [819, 1304, 2934, 3075, 3924], 'fibrosis,': [820], 'nodular': [821], 'regenerative': [822], 'hyperplasia,': [823], 'hepatoportal': [825], 'sclerosis.5-7': [826], 'nonspecific': [831], 'symptoms': [832, 1802], 'such': [833, 3093], 'worsening': [835], 'fatigue,': [836], 'dyspnea,': [837], 'peripheral': [839], 'edema.': [840], 'Men': [841], 'women': [843], 'equally': [845], 'affected.7': [846], 'No': [847, 1441, 2514], 'clear': [848], 'relationship': [849], 'exists': [850], 'between': [851, 1443, 1952], 'disease,': [855, 2553], 'degree': [856], 'hypertension,': [859, 2354, 2546], 'PPHTN.8,': [863], '9': [864, 1885, 2129, 3383], 'Treatment': [865, 2846], 'currently': [869], 'limited': [870, 2626, 2675], 'lack': [872, 1309], 'randomized': [874], 'controlled': [875], 'trials,': [876], 'concerns': [877, 2872], 'related': [878], 'drug': [880], 'delivery,': [881], 'safety': [882, 2629, 3056, 4021], 'profiles,': [883], 'failure': [885], 'reversibility': [887], 'disease.10,': [891], '11': [892, 2103, 3437], 'Vasodilators,': [893], 'particular,': [895], 'prostaglandins,3': [896], 'mainstay': [899], 'treatment.': [901], 'Sildenafil,': [902], 'phosphodiesterase-5': [904], 'inhibitor,12,': [905], '13': [906, 3490, 3828], 'dual': [909, 2566, 3106, 3853, 3880], 'endothelin': [910, 2567, 3669, 3674, 3711, 3749, 3854, 3881, 3910, 3951, 3988], 'receptor': [911, 2363, 2568, 3713, 3855, 3882, 3952, 3989], 'blocker': [912, 2569], 'bosentan,14,': [913], '15': [914, 3554], 'also': [916, 2475, 3032, 3063], 'employed': [917], 'because': [918], 'they': [919], 'easy': [921], 'use,': [923, 2279], 'well': [924, 2451], 'tolerated,': [925], 'few': [928, 2445], 'side': [929, 2446], 'effects.': [930], 'treatment': [934, 2529, 2610, 2836, 3506], 'option': [935, 953], 'most': [937], 'effective': [938, 3997], 'mild': [942, 1136, 1206, 3369], 'moderate': [944, 3371], 'PPHTN.3': [945, 2233], 'Although': [946], 'not': [947, 1143, 1178, 1193, 2244, 2509, 2898, 2920, 2965, 3026], 'contraindicated': [948], 'often': [955, 2601], 'overlooked': [956], 'Hg.': [965, 1421, 1491, 1993], 'Indeed,': [966], 'series': [969], '50%': [975], 'survived': [978], 'LT,': [980, 1455, 1871, 2026, 2052, 2249, 2291, 2342, 2756], 'survival': [983], 'enhanced': [984], 'medical': [988, 1011], 'pre-': [992], 'phases.3,': [995], '16': [996, 3585], 'previously': [1002, 2412], 'refractory': [1004, 3402], 'Standard': [1010], 'commenced,': [1014], 'but': [1015, 1107, 1171, 2423, 2508, 2662, 3031], 'had': [1016, 1546, 2760, 2776, 2966], 'little': [1017, 1153, 1330, 2664], 'impact.': [1018], 'Reductions': [1019], 'hence': [1023], 'severity,': [1025], 'were': [1026, 1122, 1139, 1192, 1784, 2172, 2520, 2853], 'only': [1027, 2698, 2921, 3027], 'observed': [1028, 2497], 'commencing': [1030], 'triple': [1032, 2726, 3006], 'agent': [1033, 2896], 'approach': [1034, 2819, 3021], 'prostacyclin': [1036, 1317, 1333, 2480], '(iloprost/epoprostenol),': [1037], 'sildenafil': [1038, 1552, 1574, 1614, 1687, 1731, 1977, 2500, 3110, 3826], '(PSB).': [1041], 'component': [1044], 'process': [1048], 'responded': [1049], 'therapy,': [1053, 1065, 3091], 'enabling': [1054, 2721], 'successful': [1055, 1072, 2261, 2278, 2722, 3002, 3039], 'LT.': [1056, 1610, 1692, 1888, 2300, 2723, 2831, 3042], 'report': [1059, 3235], 'his': [1060, 1125, 1352, 1800, 1804, 1824], 'ongoing': [1061], 'course': [1062, 1996, 2807], 'including': [1066], 'CASE': [1074], 'REPORT': [1075], 'A': [1076, 1846, 1922, 3675], '26-year-old': [1077], 'man': [1078], 'referred': [1083, 1358], 'assessment.': [1086, 1361], '1992': [1088], 'he': [1089, 1112, 1810], 'complained': [1090], 'exertional': [1092], 'dyspnea': [1093, 1116, 1667, 1828], 'abdominal': [1095], 'pain.': [1096, 1119], 'Noncirrhotic': [1097], 'diagnosed': [1101], 'absent': [1103], 'flow': [1106, 1176], 'ascites.': [1109, 1173, 3403], '2004,': [1111], 'disabling': [1114, 1666], 'progressive': [1115], 'chest': [1118, 1126, 1233, 1899], 'His': [1120], 'fingers': [1121], 'clubbed': [1123], 'asymmetrical,': [1128], 'right': [1131, 1204, 1212, 1482, 1561, 1592, 1656, 1710, 1901, 1986, 2018, 2213, 2218, 2335, 2796, 2916, 2944, 3126], 'ventricular': [1132, 1213, 1483, 1593, 1657, 1902, 1987, 2219, 2797, 2917, 3127], 'heave.': [1133], 'Splenomegaly': [1134], 'pedal': [1137], 'edema': [1138], 'present.': [1140], 'Encephalopathy': [1141], 'identified.': [1144, 1188, 3081], 'He': [1145, 1956, 2002], 'smoked': [1146], 'cigarettes': [1147], '(4': [1148], 'pack': [1149], 'years)': [1150], 'drank': [1152], 'alcohol;': [1154], 'no': [1155, 1184, 1235, 1549, 2173, 2761, 2777, 3070], 'history': [1156], 'gastrointestinal': [1158], 'hemorrhage': [1159], 'elicited.': [1161], 'Imaging': [1162], 'studies': [1163], 'found': [1164, 1510], 'changes': [1165, 2175], 'splenomegaly': [1170, 2429, 3782], 'Portal': [1174, 2353], 'seen,': [1179], 'computed': [1182, 1228], 'tomography': [1183, 1229], 'Changes': [1189], 'suggesting': [1190, 1500], 'cirrhosis': [1191, 3400, 4027], 'found.': [1194], 'Electrocardiography': [1195], 'transthoracic': [1197, 1475], 'echocardiography': [1198, 1476, 1984], 'revealed': [1199, 1234, 1248], 'hypertrophied': [1201], 'dilated': [1203], 'ventricle,': [1205], 'tricuspid': [1207], 'regurgitation,': [1208], 'estimated': [1211, 1487, 1985], 'systolic': [1214, 1484, 1594, 1658, 1752, 1903, 1988, 2798, 3128], '(normal': [1220], 'range': [1221], '[NR]': [1222], '=': [1223, 1254, 1264, 1283, 1295, 1325, 1520, 1534], '15-20': [1224], 'High-resolution': [1227], 'scan': [1230], 'evidence': [1236, 1268, 2517, 2627, 3665], 'embolic': [1239], 'interstitial': [1242], 'lung': [1243], 'disease.': [1244, 3340], 'Clinical': [1245, 3875], 'laboratory': [1246], 'evaluation': [1247], 'thrombocytopenia': [1249], '(50': [1250, 1555], '×': [1251, 1256], '109/L,': [1252], 'NR': [1253, 1263, 1274, 1282, 1294], '150-450': [1255], '109/L),': [1257], 'conjugated': [1259], 'hyperbilirubinemia': [1260], '(100': [1261, 1617, 1732], 'μmol/L,': [1262], '3-20': [1265], 'μmol/L)': [1266], 'hemolysis,': [1270], 'hyperammonemia': [1271], '(198': [1272], 'μg/dL,': [1273], '40': [1276], 'μg/dL),': [1277], 'borderline': [1278], 'hypoalbuminemia': [1279], '(36': [1280], 'g/L,': [1281], '35-50': [1284], 'g/L),': [1285], 'hypocoagulability': [1287], '(international': [1288], 'normalized': [1289], 'ratio': [1290], 'prothrombin': [1292], '1.4,': [1293], '0.9-1.2).': [1296], 'These': [1297], 'results': [1298, 2163, 2407], 'confirmed': [1299], 'presence': [1301], 'substantial': [1303], 'synthetic': [1305], 'dysfunction,': [1306], 'given': [1307, 1416, 1632, 2406], 'cirrhosis.': [1311], 'Right': [1312, 1523], 'heart': [1313, 1524, 1562, 1711, 1779, 2019, 2336, 2945, 3752], 'catheterization': [1314, 1525, 1563, 1712, 2020], 'intravenous': [1316, 2414, 3818], '(epoprostenol)': [1318], '(Table': [1319, 2032], '1)': [1320, 2816], 'demonstrated': [1321, 1697], 'moderate/severe': [1322], '47': [1326, 2118], 'reversibility.': [1331], 'Nebulized': [1332], '(iloprost—Ventavis,': [1334], 'Schering': [1335], 'Health),': [1336], 'commenced': [1338, 1937], 'dose': [1341, 1615, 2608, 2672, 2770], 'μg': [1344], 'every': [1345, 1740], '4': [1346, 1381, 1741, 1821, 2104, 3254], 'hours,': [1347, 1742], 'subjective': [1349, 2660], 'improvement': [1350, 2333, 2632, 2661, 2665], 'respiratory': [1353, 1801], 'symptoms.': [1354], 'Table': [1362, 2058], '1.': [1363], 'Responses': [1364], 'Aortic': [1366, 1389, 1422], 'Pressure': [1367, 1372, 1413], 'Pulmonary': [1369, 2060, 3335], 'Artery': [1370, 2061], 'Infusions': [1374], 'Iloprost': [1376, 1378, 1379, 2076, 2089], 'Before': [1377], 'Dosage': [1380], 'ng/kg/minute': [1382, 1384, 1386, 1388], '6': [1383, 1830, 2021, 3306], '10': [1385, 2109, 2589, 3413], '12': [1387, 1439, 3460], '120/65': [1391, 1430], '(83)': [1392, 1431], '104/69': [1393], '(86)': [1394], '102/68': [1395], '(84)': [1396], '97/61': [1397], '(78)': [1398], '96/53': [1399, 1433], '(76)': [1400, 1434], '85/29': [1402], '(47)': [1403], '87/31': [1404, 1406], '(50)': [1405, 1407], '85/31': [1408], '(51)': [1409], '81/30': [1410], '(49)': [1411], 'NOTE:': [1412, 2161], 'values': [1414], 'systolic/diastolic': [1418], '(mean)': [1419], 'pressures': [1423], 'dose-dependent': [1427], 'fashion': [1428], '(maximum': [1437], 'dosage': [1438, 1705, 2847], 'ng/kg/minute).': [1440], 'relation': [1442], 'doses': [1448], 'infusion': [1451], 'evident.': [1453, 3065], 'Abbreviations': [1454], 'transplantation;': [1457], 'mPAP,': [1458, 2317, 2600], 'pressure;': [1462, 2199, 2205, 2215], 'NR,': [1463], 'range;': [1465], 'hypertension;': [1468], 'PSB,': [1469], 'bosentan.': [1473, 2703], 'On': [1474, 3066], 'peak': [1481, 1908], '76': [1489], 'Peripheral': [1492], 'oxygen': [1493, 1515], 'saturation': [1494], '99%': [1496], 'room': [1498], 'air,': [1499], 'absence': [1502], 'shunting.': [1505], 'Arterial': [1506], 'blood': [1507, 2563, 3757], 'gas': [1508], 'analysis': [1509], 'partial': [1512], '14': [1517, 1566, 2080, 3521], 'kPa': [1518], '(NR': [1519], '10-14': [1521], 'kPa).': [1522], 'repeated,': [1527], 'iloprost,': [1529, 2502, 2906, 3009], 'demonstrating': [1530], 'As': [1538, 2594], 'severe,': [1541], 'alone': [1545], 'resulted': [1547, 2711, 2824], 'improvement,': [1550], 'oral': [1551, 3821], 'begun': [1554], 'mg': [1556, 1618, 1634, 1640, 1722, 1728, 1733, 1973, 1979], 'times': [1558, 1620, 1735, 1981], 'daily).': [1559], 'repeated': [1565, 1714, 2017], 'days': [1567, 1886], 'commencement': [1569, 1718], 'combination.': [1575], 'improved': [1578, 2029, 2350], '(45': [1579], 'therapy;': [1585, 1683, 2327], 'when': [1586], 'briefly': [1589], 'discontinued,': [1590, 3122], 'rebounded': [1596], 'presildenafil': [1598], 'levels': [1599, 2710, 2774], '(Fig.': [1600, 1766, 1920, 2687, 2815], '1).': [1601, 1767, 1921, 2688], 'However,': [1602, 2234], 'despite': [1603, 1702], 'this,': [1604], 'remained': [1606, 2809], 'too': [1607], 'high': [1608], 'response': [1612, 2676, 2941], 'escalation': [1616], 'daily)': [1621, 1736], 'appeared': [1622], 'limited,': [1623], 'third': [1625], 'agent,': [1626], '(Tracleer,': [1628], 'Actelion': [1629], 'Pharmaceuticals)': [1630], '(62.5': [1633], 'twice': [1635, 1641, 1723, 1729, 1974], 'daily,': [1636, 1975], 'increased': [1637, 2305, 2308, 3755], '125': [1639, 1721], 'daily': [1642, 1724], '1': [1644, 1715, 3150], 'month).': [1645], 'Figure': [1646], '1Open': [1647], 'figure': [1649], 'viewerPowerPoint': [1650], 'Estimated': [1651], '(dotted': [1653], 'line)': [1654, 1662], '(RVSP,': [1660], 'solid': [1661], 'presentation': [1664, 1826], 'through': [1668, 2933, 3672], 'discharge.': [1672], 'graph': [1674], 'demonstrates': [1675], 'reductions': [1676, 2771], 'RVSP': [1680], 'note': [1684, 2737, 2792], 'additions': [1685], 'There': [1693, 2171, 2624], 'remains': [1694], 'reversibility,': [1695], 'bottom': [1700], 'line,': [1701], 'near': [1703], 'maximum': [1704, 1778], 'other': [1707, 2803], 'pharmacotherapy.': [1708], 'When': [1709], 'month': [1716], 'up': [1725], '250': [1727, 1972], 'nebulizers': [1739], '37': [1746], 'right-ventricular': [1751], 'detriment': [1759, 3124], 'ejection': [1761, 2190], 'fraction': [1762], 'cardiac': [1764, 1770, 2030, 2184, 2559, 3077, 3084], 'Results': [1768, 2063], 'function': [1771, 2339, 2386, 2765, 3078, 3085], '(stress)': [1772], 'testing': [1773], 'dobutamine': [1775], 'rate': [1780], '130': [1782], 'beats/minute': [1783], 'unremarkable.': [1785], 'self-administered': [1788], 'therefore': [1793], 'continued.': [1794], 'It': [1795, 2733], 'afforded': [1796], 'good': [1797], 'control': [1798], 'exercise': [1805], 'tolerance': [1806], 'improve;': [1809], 'discharged': [1812, 1958, 2004], 'outpatient': [1814, 2006], 'care.': [1815], 'underwent': [1818], 'cadaveric': [1819], 'months': [1822, 2024], 'second': [1825], 'weeks': [1831, 2745], 'small': [1839], 'partly': [1842], 'occluded': [1843], 'thrombus.': [1845], 'piggyback': [1847], 'technique': [1848], 'used': [1850, 2435, 2820], 'end-to-end': [1852], 'biliary': [1855], 'anastomoses.': [1856], 'explanted': [1858], 'many': [1863], 'tracts': [1865], 'lacked': [1866], 'venules.': [1868], 'Immediately': [1869], 'maintained': [1874, 2270], 'previous': [1876], 'doses.': [1877], 'Renal': [1878], 'dysfunction': [1879, 1896, 2932, 3336], 'required': [1880], 'continuous': [1881], 'venovenous': [1882], 'hemofiltration': [1883], 'Care': [1889, 3167], 'complicated': [1893], 'due': [1897, 1948], 'sepsis,': [1900], '120': [1910], 'Hg,': [1912, 2242, 2720], 'which': [1913, 2036, 2504], 'settled': [1915], '62': [1917, 1991], 'renal': [1923, 1942, 4032], 'sparing': [1924], 'immunosuppression': [1925], 'selective': [1929], 'interleukin-2': [1930], 'inhibitor': [1931], 'low-dose': [1932], 'tacrolimus': [1933], 'steroids': [1935], 'view': [1939], 'postoperative': [1941], 'dysfunction.': [1943], 'Prophylactic': [1944], 'ganciclovir': [1945], 'started': [1947], 'cytomegalovirus': [1950], 'mismatch': [1951], 'donor': [1953], 'recipient.': [1955], 'intensive': [1961], 'care': [1962, 3140], 'unit': [1963], 'day': [1965], '22': [1966, 3802], 'post-LT,': [1967], 'nebulizers,': [1970], 'three': [1980], 'daily.': [1982], 'Transthoracic': [1983], 'hospital': [1995, 2012], 'point': [1999, 2790], 'uncomplicated.': [2001], 'follow-up.': [2007, 2814], 'Since': [2008], 'discharge': [2009], 'has': [2015, 2043, 2250], 'undergone': [2016], '18': [2023, 3637], 'indices': [2031], '2).': [2033], 'Allograft': [2034], 'function,': [2035], 'monitored': [2038], 'regular': [2041], 'basis,': [2042], 'been': [2044, 2373, 3080], 'than': [2048, 3443], 'since': [2051], 'regimen.': [2057], '2.': [2059, 3963], 'Catheter': [2062], 'Over': [2064], '4-Month': [2066], 'Period': [2067], 'Presentation': [2069], 'Transplantation,': [2071], 'Including': [2072], 'Effects': [2074, 3947], 'Dobutamine': [2078, 2090], 'Parameter': [2079], 'July': [2081, 2094], '2004': [2082, 2085, 2088, 2093], '21': [2083, 3770], 'September': [2084, 2087], '23': [2086, 3846], 'November': [2092], '2005': [2095], 'May': [2096], '2006': [2097], 'RA': [2098, 2211], '(mm': [2100, 2107, 2116, 2126], '8': [2102, 2744, 3352], 'RV': [2105, 2216], '29': [2112], '37-42': [2113], '33': [2114], '45': [2120, 2684, 2694, 2716], '42': [2122], 'PACWP': [2125, 2179], '7': [2128, 2131, 3330], '24': [2130, 3869], 'EDV': [2132, 2177], '(mL)': [2133, 2138], '385': [2134], '363': [2135], '183': [2136], 'ESV': [2137], '142': [2139], '110': [2140], '119': [2141], 'EF': [2142], '(%)': [2143], '26': [2144, 3940], '45-49': [2145], 'CI': [2147, 2183], '(L/minute/m2)': [2148], '3.56': [2149], '4.7': [2150], '4.6': [2151], '5-6.5': [2152], '4.1': [2153], '5.9': [2154], 'PVRI': [2155], '(dyne/second/cm−5)': [2156], '459': [2158], '517-92': [2159], '292': [2160], 'show': [2164], 'reduction': [2166, 2692, 2714, 2840], 'pressure.': [2170, 2220], 'significant': [2174, 2923], 'CI.': [2181], 'Abbreviations:': [2182], 'index;': [2185, 2210], 'EDV,': [2186], 'end-diastolic': [2187], 'volume;': [2188, 2194], 'EF,': [2189], 'fraction;': [2191], 'ESV,': [2192], 'end-systolic': [2193], 'PA': [2195], 'pressure,': [2196, 2212, 2217], 'PACWP,': [2200], 'PVRI,': [2206], 'atrial': [2214], 'DISCUSSION': [2221], 'can': [2223, 2426], 'provide': [2224], 'excellent': [2226], 'outcome': [2228, 2262], 'selected': [2230], 'excess': [2238], 'although': [2243, 2343], 'absolute': [2246], 'contraindication': [2247], 'historically': [2251], 'provided': [2252, 2659, 2728], 'important': [2254, 2735, 2788, 2953, 3097], 'threshold': [2255, 2512], 'based': [2256], 'survival.4': [2258], 'For': [2259], 'should': [2264], 'optimized': [2266], 'afterward.': [2271], 'report,': [2274], 'we': [2275, 2496, 2999], 'combination,': [2281], 'both': [2287, 2394, 2484, 3145], 'overt': [2293], 'toxicity': [2294, 2519], 'allograft': [2297, 2901, 3102, 3117], 'injury': [2298, 2587], 'manifest': [2303], 'tone,': [2307], 'resistance,': [2311], 'vasculature': [2314], 'remodeling.17': [2315], 'Lowering': [2316], 'case,': [2321, 2597], 'central': [2324], 'aim': [2325, 2834], 'it': [2329], 'postulated': [2331], 'that': [2332, 2738, 2891], 'structure': [2337], 'prior': [2340, 2746], 'secondary': [2345], 'gain,': [2346], 'would': [2347, 2989], 'likely': [2348], 'impact': [2349, 2762], 'survival.': [2352], 'mutations': [2355], 'genes': [2357], 'transforming': [2360], 'growth': [2361], 'factor': [2362], 'family,': [2364], 'imbalances': [2366], 'circulating': [2368], 'vasoactive': [2369], 'compounds': [2370], 'all': [2372, 2753], 'implicated': [2374], 'PPHTN.18,': [2376], '19': [2377, 3690], 'Prostacyclin,': [2378], 'potent': [2380], 'vasodilator,': [2382], 'acts': [2383], 'upon': [2384], 'platelet': [2385], 'induces': [2388], 'vasodilatation': [2389], 'direct': [2391], 'action': [2392, 2486], 'smooth': [2395, 2466], 'muscle': [2396, 2467], 'endothelium.': [2399], 'Oral': [2400], 'nebulized': [2402], 'analogs': [2403], 'now': [2405], 'comparable': [2408], 'those': [2410], 'obtained': [2411], 'prostacyclin.20': [2415], 'Prostacyclin': [2416, 2653, 3119], 'cytoprotective': [2419], 'effects': [2420, 3045], 'hepatocytes,': [2422], 'chronic': [2424, 2551, 3338], 'administration': [2425, 2598], 'result': [2427], 'pancytopenia.21': [2431], 'Phosphodiesterase': [2432, 3465], 'inhibitors': [2433], 'successfully': [2436], 'lower': [2438], 'hypertension.22': [2441], 'They': [2442, 2453], 'relatively': [2444], 'effects,': [2447, 2870], 'generally': [2450], 'tolerated.': [2452], 'act': [2454], 'stabilizing': [2456], 'cyclic': [2457], 'guanosine': [2458], 'monophosphate': [2459], 'compounds.12': [2462], 'potentiates': [2464], 'NO-mediated': [2465], 'relaxation': [2468], 'and,': [2469], 'thereby,': [2470], 'vasodilatation.': [2471], 'Their': [2472], 'effectors': [2473], 'involved': [2476], 'metabolism': [2478], 'potentiate': [2483], 'complication': [2489, 2914], 'profiles': [2490], 'prostacyclin.': [2492], 'case': [2495, 2649, 2852, 2889, 2971], 'synergy': [2498], 'level.': [2513], 'complications': [2515, 3313], 'noted.': [2521], 'Endothelin': [2522], 'antagonists': [2523], 'increasing': [2525], 'utilized': [2526], 'primary': [2531], 'hypertension.14': [2534], 'Levels': [2535], 'endothelin-1': [2537, 3660, 3708], 'rat': [2541], 'models': [2542], 'inversely': [2556], 'proportionate': [2557], 'flow.20': [2564], 'eliminated': [2572], 'via': [2573], 'hepatobiliary': [2575, 2586], 'tract;': [2576], 'thus,': [2577], 'bile': [2578, 3916, 3955], 'salt': [2579, 3917, 3956], 'accumulation': [2580], 'occur,': [2582], 'risk': [2584], '15%': [2591], 'patients.23-26': [2593], 'lowers': [2599], 'dose-related': [2604], 'fashion.': [2605], 'ideal': [2607], 'duration': [2611], 'either': [2614, 2980, 3074], 'goal,': [2621], 'unknown.27': [2623], 'efficiency,': [2631], 'functional': [2634, 2783], 'status,': [2635], 'Child-Turcotte-Pugh': [2637], 'score': [2638], 'advanced': [2640], 'disease.28': [2642], 'sequentially.': [2652], 'single': [2657], 'agents,': [2658, 2882], 'objectively': [2663], 'mPAP.': [2667, 2857], 'With': [2668], 'escalation,': [2673], 'noted': [2678], 'important,': [2690], 'persistent': [2691], 'occurred': [2697], 'addition': [2701], 'therapeutic': [2709, 2731], 'Thus,': [2724], 'greatest': [2730], 'effect.': [2732], 'high-dose': [2742], 'prolonged': [2750], 'agents': [2754, 3024, 3146], 'standard': [2758], 'immunosuppression,': [2759], 'graft': [2764, 2931], 'patient.': [2768], 'Subsequent': [2769], 'detrimental': [2778], 'influence': [2779], 'capacity': [2784], 'date.': [2786], 'An': [2787], 'practical': [2789], 'mirrored': [2801], 'each': [2802], 'throughout': [2804], 'low': [2810, 3134], '2-year': [2813], 'triple-agent': [2818], 'sustained': [2826], 'lowering': [2827, 3050], 'main': [2833], 'morbidity': [2843, 2924], 'mortality.': [2845], 'directed': [2854, 3025], 'toward': [2855], 'reducing': [2856], 'Our': [2858], 'experience': [2859], 'vasodilators,': [2864], 'particularly': [2865], 'apparent': [2868], 'adverse': [2869, 3071, 3925], 'allays': [2871], 'regarding': [2873], 'health': [2875], 'allografts': [2878], 'exposed': [2879], 'these': [2881], 'context': [2885], 'immunosuppression.': [2887], 'confirms': [2890], 'prejudicial': [2899], 'health.': [2902], 'Continued': [2903], 'prevented': [2912], 'failure,': [2918], 'but,': [2925], 'also,': [2926], 'patient,': [2929], 'congestion.': [2935, 3104], 'Careful': [2936], 'selection': [2938], 'stress': [2948], 'reperfusion': [2950], 'factors': [2954], 'success': [2957], 'PPHTN.': [2962, 3018], 'opportunity': [2968], 'evaluate': [2973], 'findings': [2976], 'histological': [2978], 'grounds': [2979], 'This,': [2987], 'however,': [2988], 'interest': [2992], 'larger': [2995], 'study.': [2996, 3202], 'multiple': [3023], 'endothelial': [3029], 'blockade': [3030], 'localized': [3034], 'vasodilatation,': [3036], 'providing': [3037], 'beneficial': [3044], 'follow-up,': [3067, 3136], 'date,': [3069, 3115], 'consequences': [3072], 'Return': [3082], 'require': [3089], 'however;': [3092], 'protecting': [3099], 'continues': [3113], 'injury.': [3118], 'recently': [3121], 'pressures.': [3129], 'If': [3130], 'hemodynamic': [3131], 'parameters': [3132], 'remain': [3133], 'plan': [3138], 'withdraw': [3144], 'over': [3147], 'time.': [3148], 'REFERENCES': [3149], 'Krowka': [3151, 3215, 3288, 3355, 3775], 'MJ,': [3152, 3216, 3289, 3776], 'Plevak': [3153, 3353, 3773], 'D.': [3154], 'distinct': [3156], 'concepts': [3157], 'implications': [3159], 'hepatopulmonary': [3161, 3295, 3317, 3718], 'syndrome': [3162, 3230, 3719], 'Crit': [3166], 'Med': [3168, 3545], '2005;': [3169, 3322, 3577, 4000], '33:': [3170], '470.': [3171], 'CrossrefPubMedWeb': [3172, 3302, 3633, 3842, 4004], 'Science®Google': [3174, 3212, 3252, 3283, 3304, 3328, 3350, 3381, 3411, 3435, 3458, 3488, 3519, 3552, 3583, 3635, 3688, 3732, 3768, 3800, 3844, 3867, 3892, 3938, 3975, 4006, 4044], 'Scholar': [3175, 3213, 3253, 3284, 3305, 3329, 3351, 3382, 3412, 3436, 3459, 3489, 3520, 3553, 3584, 3615, 3636, 3689, 3733, 3769, 3801, 3845, 3868, 3893, 3939, 3976, 4007, 4045], 'Colle': [3177], 'IO,': [3178], 'Moreau': [3179], 'R,': [3180, 3494, 3618], 'Godinho': [3181], 'E,': [3182, 3496], 'Belghiti': [3183], 'J,': [3184, 3566, 3694, 3740, 3871, 3904, 4014], 'Ettori': [3185], 'F,': [3186, 3492, 3641, 4010], 'Cohen-Solal': [3187], 'A,': [3188, 3500, 3533, 3645], 'et': [3189, 3227, 3503, 3534, 3567, 3650, 3703], 'al.': [3190, 3228, 3504, 3535, 3568, 3651, 3704], 'Diagnosis': [3191], 'candidates': [3196], 'transplantation:': [3199], 'prospective': [3201], 'Hepatology': [3203, 3341, 3426, 3449, 3723], '2003;': [3204, 3405, 3427, 3629], '37:': [3205, 3428], '401–': [3206], '409.': [3207], 'LibraryPubMedWeb': [3210, 3433], 'Mandell': [3217], 'MS,': [3218], 'Ramsay': [3219, 3586, 3592], 'MA,': [3220, 3587], 'Kawut': [3221], 'SM,': [3222], 'Fallon': [3223, 3307, 3331, 3414, 3438], 'MB,': [3224, 3332], 'Manzarbeitia': [3225], 'C,': [3226, 3560, 3595, 3898, 3902, 3979], 'Hepatopulmonary': [3229, 3440], 'hypertension:': [3233, 3417, 3622, 3993], 'multicenter': [3238], 'transplant': [3240, 3274, 3603], 'database.': [3241], '2004;': [3244, 3298, 3482, 3724, 3886], '10:': [3245], '174–': [3246], '182.': [3247], 'LibraryCASPubMedWeb': [3250, 3348, 3456, 3730, 3798, 3936, 3973], 'Kuo': [3255], 'PC,': [3256], 'Plotkin': [3257], 'JS,': [3258], 'Gaine': [3259], 'S,': [3260, 3358, 3391, 3643, 3647], 'Schroeder': [3261], 'RA,': [3262], 'Rustgi': [3263], 'VK,': [3264], 'Rubin': [3265, 3522, 3847], 'LJ,': [3266, 3523, 3848], 'Johnson': [3267, 3803], 'LB.': [3268], 'candidate.': [3275], 'Transplantation': [3276], '1999;': [3277, 3792], '67:': [3278], '1087–': [3279], '1093.': [3280], 'CrossrefCASPubMedWeb': [3281, 3326, 3409, 3486, 3517, 3550, 3581, 3686, 3766, 3865, 3890, 4042], '5': [3285, 3466], 'Hoeper': [3286, 3555], 'MM,': [3287, 3556], 'Strassburg': [3290], 'CP.': [3291], 'syndrome.': [3296, 3318], 'Lancet': [3297], '363:': [3299], '1461–': [3300], '1468.': [3301], 'MB.': [3308, 3415, 3439], 'Mechanisms': [3309], 'disease:': [3316], 'J': [3319, 3512, 3544, 3576, 3760, 3834, 4035], 'Clin': [3320, 3480, 3884, 3927], 'Gastroenterol': [3321, 4036], '39:': [3323, 3725], 'S138–': [3324], 'S142.': [3325], 'Abrams': [3333], 'GA.': [3334], '2000;': [3342], '32:': [3343], '859–': [3344], '865.': [3345], 'D,': [3354, 3698], 'M,': [3356, 3387, 3558, 3900], 'Rettke': [3357], 'Dunn': [3359], 'W,': [3360], 'Southorn': [3361], 'P.': [3362], 'Successful': [3363], 'Transplant': [3374, 3837], 'Proc': [3375], '1993;': [3376, 3762], '25:': [3377, 3578], '1840.': [3378], 'PubMedWeb': [3379], 'Benjaminov': [3384], 'FS,': [3385], 'Prentice': [3386], 'Sniderman': [3388], 'KW,': [3389], 'Siu': [3390], 'Liu': [3392, 3699], 'P,': [3393], 'Wong': [3394], 'F.': [3395], 'decompensated': [3399], 'Gut': [3404], '52:': [3406], '1355–': [3407], '1362.': [3408], 'new': [3418], 'clinical': [3419], 'insights': [3420], 'questions': [3423], 'pathogenesis.': [3425], '253–': [3429], '255.': [3430], 'syndrome:': [3441], 'just': [3444], 'matter': [3446], 'tone?': [3448], '2006;': [3450, 3513, 3682, 4038], '43:': [3451, 3887], '912–': [3452], '914.': [3453], 'Kulkarni': [3461], 'SK,': [3462], 'Patil': [3463], 'CS.': [3464], 'enzyme': [3467], 'its': [3469], 'inhibitors:': [3470], 'update': [3471], 'pharmacological': [3473], 'therapeutical': [3475], 'aspects.': [3476], 'Methods': [3477], 'Find': [3478], 'Exp': [3479], 'Pharmacol': [3481, 3928], '26:': [3483, 3683, 3839], '789–': [3484], '799.': [3485], 'Reichenberger': [3491], 'Voswinckel': [3493], 'Steveling': [3495], 'Enke': [3497], 'B,': [3498, 3696, 3906], 'Kreckel': [3499], 'Olschewski': [3501], 'H,': [3502], 'Sildenafil': [3505], 'Eur': [3510, 3574, 4034], 'Respir': [3511, 3575], '28:': [3514, 3968], '563–': [3515], '567.': [3516], 'Badesch': [3524], 'DB,': [3525], 'Barst': [3526], 'RJ,': [3527], 'Galie': [3528], 'N,': [3529], 'Black': [3530], 'CM,': [3531], 'Keogh': [3532], 'Bosentan': [3536, 3569], 'N': [3542], 'Engl': [3543], '2002;': [3546, 3861], '346:': [3547], '896–': [3548], '903.': [3549], 'Halank': [3557], 'Marx': [3559], 'Hoeffken': [3561], 'G,': [3562], 'Seyfarth': [3563], 'HJ,': [3564], 'Schauer': [3565], '502–': [3579], '508.': [3580], 'Simpson': [3588], 'BR,': [3589], 'Nguyen': [3590], 'AT,': [3591], 'KJ,': [3593], 'East': [3594], 'Klintmalm': [3596], 'GB.': [3597], 'Severe': [3598], 'candidates.': [3604], 'Surg': [3607, 3791], '1997;': [3608], '3:': [3609], '494–': [3610], '500.': [3611], 'LibraryCASPubMedGoogle': [3614], '17': [3616], 'Budhiraja': [3617], 'Hassoun': [3619], 'PM.': [3620], 'tale': [3624], 'two': [3626], 'circulations.': [3627], 'Chest': [3628], '123:': [3630], '562–': [3631], '576.': [3632], 'Shi-Wen': [3638], 'X,': [3639], 'Rodriguez-Pascual': [3640], 'Lamas': [3642], 'Holmes': [3644], 'Howat': [3646], 'Pearson': [3648], 'JD,': [3649], 'Constitutive': [3652], 'ALK5-independent': [3653], 'c-Jun': [3654], 'N-terminal': [3655], 'kinase': [3656], 'activation': [3657], 'contributes': [3658], 'overexpression': [3661], 'fibrosis:': [3664], 'autocrine': [3668], 'loop': [3670], 'operating': [3671], 'B': [3677, 3712], 'receptors.': [3678], 'Mol': [3679], 'Cell': [3680], 'Biol': [3681], '5518–': [3684], '5527.': [3685], 'Ling': [3691], 'Y,': [3692, 3942], 'Zhang': [3693], 'Luo': [3695], 'Song': [3697], 'L,': [3700, 3702], 'Tang': [3701], 'role': [3706], 'pathogenesis': [3716], 'rat.': [3722], '1593–': [3726], '1602.': [3727], '20': [3734], 'Vincent': [3735], 'JA,': [3736], 'Ross': [3737], 'RD,': [3738], 'Kassab': [3739], 'Hsu': [3741], 'JM,': [3742], 'Pinsky': [3743], 'WW.': [3744], 'Relation': [3745], 'plasma': [3748], 'flow.': [3758], 'Am': [3759], 'Cardiol': [3761], '71:': [3763], '1204–': [3764], '1207.': [3765], 'Findlay': [3771], 'JY,': [3772], 'DJ,': [3774], 'Sack': [3777], 'EM,': [3778], 'Porayko': [3779], 'MK.': [3780], 'Progressive': [3781], 'epoprostenol': [3784, 3819], '5:': [3793], '362–': [3794], '365.': [3795], 'RF,': [3804], 'Loyd': [3805], 'JE,': [3806], 'Mullican': [3807], 'AL,': [3808], 'Fink': [3809], 'CA,': [3810], 'Robbins': [3811], 'IM.': [3812], 'Long-term': [3813], 'follow-up': [3814], 'conversion': [3816], 'Heart': [3835], 'Lung': [3836], '2007;': [3838, 3967], '363–': [3840], '369.': [3841], 'Roux': [3849], 'Bosentan:': [3851], 'antagonist.': [3856, 3883], 'Expert': [3857], 'Opin': [3858], 'Investig': [3859], 'Drugs': [3860], '11:': [3862], '991–': [3863], '1002.': [3864], 'Dingemanse': [3870], 'van': [3872], 'Giersbergen': [3873], 'PL.': [3874], 'pharmacology': [3876], 'Pharmacokinet': [3885], '1089–': [3888], '1115.': [3889], 'Fattinger': [3895], 'K,': [3896], 'Funk': [3897], 'Pantze': [3899], 'Weber': [3901], 'Reichen': [3903, 4013], 'Stieger': [3905], 'Meier': [3907], 'PJ.': [3908], 'antagonist': [3911, 3990], 'inhibits': [3913], 'canalicular': [3915], 'export': [3918, 3957], 'pump:': [3919], 'potential': [3921], 'mechanism': [3922], 'reactions.': [3926], 'Ther': [3929], '2001;': [3930], '69:': [3931], '223–': [3932], '231.': [3933], 'Mano': [3941], 'Usui': [3943], 'T,': [3944], 'Kamimura': [3945], 'H.': [3946], 'antagonist,': [3953], 'pump': [3958], 'multidrug': [3960], 'resistance-associated': [3961], 'protein': [3962], 'Biopharm': [3964], 'Drug': [3965], 'Dispos': [3966], '13–': [3969], '18.': [3970], 'Kuntzen': [3978], 'Gulberg': [3980], 'V,': [3981], 'Gerbes': [3982], 'AL.': [3983], 'mixed': [3987], 'safe': [3995], 'therapy?': [3998], 'Gastroenterology': [3999], '128:': [4001], '164–': [4002], '168.': [4003], 'Barth': [4009], 'Gerber': [4011], 'PJ,': [4012], 'Dufour': [4015], 'JF,': [4016], 'Nicod': [4017], 'LP.': [4018], 'Efficiency': [4019], 'Child': [4025], 'C': [4026], 'insufficiency.': [4033], 'Hepatol': [4037], '18:': [4039], '1117–': [4040], '1119.': [4041], 'Citing': [4046], 'Literature': [4047], 'Volume14,': [4048], 'Issue3March': [4049], '2008Pages': [4050], 'FiguresReferencesRelatedInformation': [4052]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2066012394', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2023, 'cited_by_count': 1}, {'year': 2022, 'cited_by_count': 4}, {'year': 2021, 'cited_by_count': 2}, {'year': 2020, 'cited_by_count': 5}, {'year': 2019, 'cited_by_count': 4}, {'year': 2018, 'cited_by_count': 6}, {'year': 2017, 'cited_by_count': 8}, {'year': 2016, 'cited_by_count': 6}, {'year': 2015, 'cited_by_count': 10}, {'year': 2014, 'cited_by_count': 3}, {'year': 2013, 'cited_by_count': 10}, {'year': 2012, 'cited_by_count': 9}], 'updated_date': '2024-09-09T16:43:34.895434', 'created_date': '2016-06-24'}