Publication Information

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1289, 1315], 'vigorous': [58], 'specific': [60], 'neutralizing': [61], 'response.7,': [63], '8': [64], 'Prevalence': [65], 'this': [67, 493, 660, 682, 908, 1225], 'MCC': [68, 78, 86, 95, 121, 139, 156, 183, 224, 238, 245, 301, 307, 382, 463, 486, 498, 522, 572, 603, 647, 673, 846, 875, 878, 934, 956, 994, 1021, 1045, 1070, 1146, 1179, 1193, 1240, 1267, 1275], 'phenotype': [69, 159], 'has': [70, 566, 1142], 'been': [71, 330, 459, 567, 1143], 'reported': [72, 155], 'as': [73, 281, 474, 913, 924, 1103, 1194, 1207, 1209], 'upward': [74], '77–84%': [76], 'tested.1,': [79], '3,': [80], '9,': [81], '10': [82, 541], 'Thus,': [83], '16–23%': [84], 'may': [87, 128, 606, 755, 976, 1154, 1216], 'have': [88, 329, 458, 607, 619, 1033], 'different': [90], 'etiology.': [91], 'detection': [93, 106, 250, 269, 613, 903], 'tissue': [96, 308, 1081], 'includes': [97], 'MCCs': [98, 1008, 1119], 'with': [99, 122, 145, 160, 184, 232, 336, 372, 385, 436, 488, 515, 561, 614, 674, 731, 828, 847, 855, 887, 1022, 1133, 1243, 1271], 'low': [102, 123, 185, 505, 675, 806, 848, 889, 1023, 1036, 1137], 'numbers,': [105], 'ranges': [107], 'from': [108, 215, 262, 284, 534, 805, 931, 936], '24': [109], '100%': [111], '(Table': [112, 136], '1).1-4,': [113], '6,': [114], '9-19': [115], 'Differences': [116], 'relative': [118, 391], 'proportions': [119], 'viral': [126, 146, 186, 421, 426, 432, 437, 464, 483, 508, 517, 544, 563, 587, 599, 676, 808, 824, 860, 892, 1000, 1013, 1024, 1037, 1074, 1121, 1140, 1152, 1165], 'copies': [127, 311], 'also': [129, 728], 'be': [130, 442, 574, 684, 853, 882, 939, 942, 977, 985, 1063, 1217, 1277], 'significantly': [131], 'influenced': [132], 'geographic': [134, 1264], 'region': [135], '2).13': [137], 'All': [138, 1215], 'tumors': [140, 375, 439, 886, 968, 1046], 'our': [142, 496, 595], 'study': [143, 178, 720, 879, 1234], 'population6': [144], 'abundance': [147, 468, 484, 807, 1075, 1138, 1196, 1255], '0.06–1.2': [149], 'copies/cell': [151, 518], 'conform': [152], 'positive': [158, 223, 374, 438, 965], 'demonstrable': [161], 'LTA': [163, 201, 272, 342, 364, 373, 386, 419, 424, 430, 611, 739], '(IHC': [164], 'CM2B4,': [165], 'kindly': [166], 'provided': [167], 'Dr.': [169, 285, 1286, 1290, 1306], 'Moore)': [170], 'protein': [173, 255, 590], '(Fig.': [174, 530, 960], '1a).': [175], 'Our': [176, 490, 633, 958], 'tumor': [177, 302, 560, 604, 648, 658, 714, 779, 830, 835, 910, 1085, 1088, 1241], 'population': [179, 499, 880, 1242], 'additionally': [180], 'contained': [181], 'variant': [182, 1187], '(0.0005–0.0035': [188], 'copies/cell)': [189, 1040], 'or': [190, 506, 601, 609, 832, 1197, 1212], 'no': [191, 507, 608, 891], 'detectable': [192, 1200], 'virus;': [193], 'these': [194, 456, 866], 'later': [195], '2': [196], 'subgroups': [197], 'were': [198, 296, 315, 547], 'negative': [199, 387, 571, 602, 944, 967], '(CM2B4)': [202], 'protein.': [205], 'These': [206, 294], 'data': [207, 214, 596, 959], 'are': [208, 230, 775, 1283], 'similar': [209, 1136], 'more': [212], 'recent': [213, 234, 617, 768], 'Busam': [216], 'et': [217, 478, 539, 1003, 1056], 'al.4': [218], 'who': [219, 480], 'found': [220, 1034], '5/15': [221], 'non': [225, 657, 834, 1087, 1164], 'reactive': [226], 'CM2B4': [228, 278, 344, 366, 556, 570, 592, 1300], 'consistent': [231], 'comprehensive': [235], 'characterization': [236], 'cell': [239, 313, 1016, 1147], 'lines.20': [240], '(a)': [241], 'Immunohistochemical': [242], 'staining': [243, 368], 'was': [246, 398], 'performed': [247], '(pRb)': [256], 'using': [257, 276, 321, 343, 1235], 'commercially': [259], 'available': [260], 'Novocastra': [263], '(clone': [264], '13A10)': [265], 'encoded': [273], 'mAb': [279, 345, 367], 'obtained': [280], 'gift': [283], 'Patrick': [286, 1287], 'Moore': [287, 1288], 'Yuan': [289, 1291], 'Chang': [290, 1292], '(University': [291, 1293], 'Pittsburgh).': [293], 'antibodies': [295], 'applied': [297], 'formalin-fixed': [299], 'paraffin-embedded': [300], 'core': [303], 'samples': [304], 'an': [306, 757, 1236, 1278], 'microarray.': [309], 'per': [312, 400, 1015], '(CPC)': [314], 'determined': [316], 'real': [318], 'time': [319], 'PCR': [320, 327, 1096], 'Taqman': [322], 'technology.': [323], 'Details': [324], 'assay': [328], 'described': [331, 460, 1144], 'previously.6': [332, 461], 'CPC': [334], 'associates': [335], '(first': [337], 'row)': [338, 348], '(second': [347], 'pRb.': [351], '(b)': [352], 'Correlation': [353], 'between': [354, 641], 'overall': [355], 'survival': [356, 397, 510], '(Kaplan': [357], 'Meier)': [358], 'presence': [361, 621, 643, 652, 733, 751, 857, 1204], 'demonstrates': [369], 'that': [370, 482, 598, 698, 771, 963, 983, 1006, 1113, 1123, 1150], 'patients': [371, 384, 457], 'survived': [376], 'longer': [377], 'following': [378], 'diagnosis': [380], 'than': [383, 1127], 'tumors.': [388, 867, 1071], 'By': [389], 'Cox': [390], 'hazard': [392], '(RH)': [393], 'analysis,': [394], 'likelihood': [395], 'lower': [399], 'level': [401], '(HR': [402], '=': 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'best': [512], 'those': [514], 'worse': [520], 'likely': [523, 700], 'initiated': [524], 'through': [525], 'other': [526, 628, 1107], 'modes': [527], '1b).': [531], 'We': [532, 1189], 'report': [536], 'Becker': [538], 'al.3,': [540], 'where': [542], 'numbers': [546], 'present': [548], 'most': [550, 1007], 'their': [552], 'samples.': [553], 'Lack': [554], 'described.2': [568], 'Some': [569], 'might': [573, 938], 'ascribed': [575], 'variations': [577], 'antigenic': [581], 'epitopes.': [582], 'However,': [583, 767], 'correlation': [585], 'among': [586, 1181], 'load,': [588], 'suggests': [597], 'low-abundance': [600, 1069], 'cells': [605, 649, 831, 836, 844, 1089, 1131], 'insufficient': [610], 'CM2B4.': [615], 'Several': [616], 'reports': [618], 'normal': [625, 782], 'tumors.6,': [629], '11,': [630], '14,': [631], '21': [632], 'results': [634], 'do': [635, 1018], 'allow': [637], 'us': [638], 'discriminate': [640], 'surrounding': [656], 'cells;': [659], 'issue': [661, 821], 'germane': [663], 'relevance': [666, 788], 'mediated': [669, 708], 'tumorigenesis': [670], 'particularly': [671, 804], 'abundance.': [677, 1001, 1025], 'One': [678], 'approach': [679], 'address': [681, 819], 'would': [683, 852, 1276], 'examine': [686], 'whether': [687, 745, 822], 'genome': [689, 726], 'integrated': [691], 'host': [694], 'genome,': [695], 'process': [697], 'indicate': [702], 'direct': [704], 'role': [705, 764, 990], 'oncogenesis.': [709], 'lack': [711], 'fresh/frozen': [713], 'samples,': [715], 'however,': [716], 'makes': [717], 'such': [718, 753, 912, 923], 'technically': [721, 797], 'unfeasible.': [722], 'Integration': [723], 'often': [729], 'associated': [730, 827], 'truncating': [735, 773, 791], 'while': [741], 'it': [742, 1111], 'unknown': [744], 'occur': [747], 'before': [748, 862, 1301], 'provide': [756, 1156], 'alternative': [758], 'surrogate': [759], 'supporting': [761], 'pathogenic': [763, 787], 'MCPyV.': [766, 1134], 'data21': [769], 'suggest': [770], 'identical': [772], 'detected': [776], 'both': [778], 'adjacent': [781], 'tissue,': [784], 'thus': [785], 'detecting': [790, 802], 'warrant': [793], 'additional': [794], 'investigation.': [795], 'Although': [796, 894], 'feasible,': [798], 'sensitivities': [800], 'pose': [810], 'several': [811], 'challenges': [812], 'will': [814, 984, 995], 'still': [815], 'fail': [816], 'directly': [818], 'sample.': [839], 'Nonetheless,': [840], 'rarity': [842], 'amplification': [849], 'inconsistent': [854], 'clonal': [863], 'expansion': [864], 'To': [868, 1224], 'appreciate': [869], 'differences': [871, 901, 1079], 'survival,': [876], 'must': [881, 926], 'heterogeneous': [883], 'contain': [885], 'high,': [888], 'detection.': [893], 'artifact': [895], 'related': [896], 'specimen': [898], 'quality': [899], 'methods': [904, 1251], 'could': [905], 'add': [906], 'heterogeneity,': [909], 'factors': [911], 'mutations,': [914], 'ultraviolet': [915], '(UV)': [916], 'damage': [918], 'clinical': [921, 981, 1211, 1272], 'parameters': [922], 'immunosuppression': [925], 'contribute.': [927], 'Compared': [928], 'specimens': [930], 'North': [932], 'America,': [933], 'tissues': [935], 'Australia': [937], 'expected': [940], 'because': [945], 'UV': [947], 'radiation': [948], 'exposure': [949], 'melanin-deficient': [951], 'probably': [953], 'contributes': [954], 'development.13': [957], '1a)': [961], 'imply': [962], 'oncoprotein': [971], 'prognosis.': [974], 'This': [975], 'important': [978, 1219, 1279], 'establishing': [980], 'useful': [986, 1313], 'worldwide.': [987], 'Clarifying': [988], 'require': [996], 'accurate': [997], 'quantification': [998], 'Houben': [1002], 'al.3': [1004], 'contend': [1005], 'carry': [1009, 1120], 'at': [1010, 1114, 1159], 'least': [1011, 1115, 1160], '1': [1012, 1049, 1128], 'find': [1020, 1190], 'In': [1026], 'contrast,': [1027], 'we': [1028, 1053], 'others6,': [1030], '13,': [1031], '16': [1032], 'very': [1035], 'loads': [1038], '(0.0001–0.0035': [1039], '19': [1042], '174': [1044], 'tested': [1047], '(Tables': [1048], '2).': [1051], 'Both': [1052], 'Garneski': [1055], 'al.6,': [1057], '13': [1058], 'observe': [1059], 'what': [1060], 'appear': [1061], 'discrete': [1064], 'categories': [1065], 'high-': [1067], 'Estimation': [1072], 'susceptible': [1077], 'quality,': [1082], 'proportion': [1083, 1117], 'sample,': [1092], 'primers': [1093], 'selected': [1094], 'amplification,': [1097], 'target': [1098], 'cellular': [1099], 'genomic': [1100], 'sequences': [1101], 'used': [1102], 'reference': [1105], 'technical': [1108], 'differences,': [1109], 'equates': [1124], 'less': [1126], '300': [1130], 'infected': [1132, 1166], 'Notably,': [1135], 'association': [1141, 1153], 'lines,': [1148], 'suggesting': [1149], 'mere': [1151], 'growth': [1157], 'advantage,': [1158], 'vitro,': [1162], 'over': [1163], 'MCC.20': [1167], 'Finally,': [1168], 'there': [1169], 'question': [1172], 'how': [1174], 'oncoproteins': [1177, 1206, 1257], 'differs': [1180], 'classic': [1183], 'phenotypes.': [1188], 'heterogeneity': [1191], 'absence': [1198], 'well': [1208], 'geographic,': [1210], 'factors.': [1214], 'critically': [1218], 'prognosis': [1221], 'therapy.': [1223], 'end,': [1226], 'development': [1228], 'multi-investigator,': [1231], 'multi-institutional': [1232], 'consensus': [1233], 'international,': [1237], 'geographically': [1238], 'diverse': [1239], 'pre-determined': [1245], 'common': [1246], 'set': [1247], 'reagents': [1249], 'estimate': [1253], 'primary,': [1259], 'recurrent': [1260], 'metastatic': [1262], 'lesions,': [1263], 'distributions': [1265], 'types': [1268], 'correlations': [1270], 'features': [1273], 'step.': [1280], 'authors': [1282], 'grateful': [1284], 'Pittsburgh)': [1295], 'sharing': [1297], 'its': [1302], 'publication.': [1303], 'They': [1304], 'thank': [1305], 'Allan': [1307], 'Hildesheim': [1308], '(IIB,': [1309], 'DCEG,': [1310], 'NCI)': [1311], 'discussions': [1314], 'critical': [1317], 'reading': [1318], 'manuscript.': [1321], 'Yours': [1322], 'sincerely,': [1323], 'Kishor': [1324], 'Bhatia,': [1325], 'James': [1326], 'J.': [1327], 'Goedert,': [1328], 'Rama': [1329], 'Modali,': [1330], 'Liliana': [1331], 'Preiss,': [1332], 'Leona': [1333], 'W.': [1334], 'Ayers.': [1335]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2065933146', 'counts_by_year': [{'year': 2023, 'cited_by_count': 4}, {'year': 2022, 'cited_by_count': 1}, {'year': 2021, 'cited_by_count': 3}, {'year': 2020, 'cited_by_count': 1}, {'year': 2019, 'cited_by_count': 6}, {'year': 2018, 'cited_by_count': 9}, {'year': 2017, 'cited_by_count': 3}, {'year': 2016, 'cited_by_count': 7}, {'year': 2015, 'cited_by_count': 7}, {'year': 2014, 'cited_by_count': 16}, {'year': 2013, 'cited_by_count': 9}, {'year': 2012, 'cited_by_count': 10}], 'updated_date': '2025-01-13T01:18:36.636912', 'created_date': '2016-06-24'}