Title: The characterization of substituted nitroimidazoles on paper and thin layer chromatography by colorimetric reactions
Abstract: A method is described for the separation and characterization of certain substituted nitroimidazoles by paper and thin layer chromatography. The colorimetric reaction of these compounds with β-dimethylaminobenzaldehyde, diazotized sulfanilic acid, and ninhydrin are discussed and a plausible mechanism for each reaction has been proposed. 2-Methyl-4(5)-nitroimidazoles reacted with ninhydrin to yield a characteristic green color. This is a new color reaction for this reagent and appears to involve condensation of the ninhydrin molecule on an active methylene group on an imidazole ring.
Publication Year: 1967
Publication Date: 1967-01-01
Language: en
Type: article
Indexed In: ['crossref', 'pubmed']
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Cited By Count: 16
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