Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2065722216', 'doi': 'https://doi.org/10.1002/(sici)1096-9063(199704)49:4<319::aid-ps537>3.0.co;2-k', 'title': 'Sites of Action of Noncompetitive GABA Antagonists in Houseflies and Rats: Three-Dimensional QSAR Analysis', 'display_name': 'Sites of Action of Noncompetitive GABA Antagonists in Houseflies and Rats: Three-Dimensional QSAR Analysis', 'publication_year': 1997, 'publication_date': '1997-04-01', 'ids': {'openalex': 'https://openalex.org/W2065722216', 'doi': 'https://doi.org/10.1002/(sici)1096-9063(199704)49:4<319::aid-ps537>3.0.co;2-k', 'mag': '2065722216'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1002/(sici)1096-9063(199704)49:4<319::aid-ps537>3.0.co;2-k', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S160044600', 'display_name': 'Pesticide Science', 'issn_l': '0031-613X', 'issn': ['0031-613X', '1096-9063'], 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5026604736', 'display_name': 'Miki Akamatsu', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I22299242', 'display_name': 'Kyoto University', 'ror': 'https://ror.org/02kpeqv85', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I22299242']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Miki Akamatsu', 'raw_affiliation_strings': ['Department of Agricultural Chemistry, Kyoto University, Kyoto 606–01, Japan'], 'affiliations': [{'raw_affiliation_string': 'Department of Agricultural Chemistry, Kyoto University, Kyoto 606–01, Japan', 'institution_ids': ['https://openalex.org/I22299242']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5040715675', 'display_name': 'Yoshihisa Ozoe', 'orcid': 'https://orcid.org/0000-0003-4708-9498'}, 'institutions': [{'id': 'https://openalex.org/I169016828', 'display_name': 'Shimane University', 'ror': 'https://ror.org/01jaaym28', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I169016828']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Yoshihisa Ozoe', 'raw_affiliation_strings': ['Department of Life Science and Biotechnology, Shimane University, Matsue, Shimane 690, Japan'], 'affiliations': [{'raw_affiliation_string': 'Department of Life Science and Biotechnology, Shimane University, Matsue, Shimane 690, Japan', 'institution_ids': ['https://openalex.org/I169016828']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5110386092', 'display_name': 'Tamio Ueno', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I22299242', 'display_name': 'Kyoto University', 'ror': 'https://ror.org/02kpeqv85', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I22299242']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Tamio Ueno', 'raw_affiliation_strings': ['Department of Agricultural Chemistry, Kyoto University, Kyoto 606–01, Japan'], 'affiliations': [{'raw_affiliation_string': 'Department of Agricultural Chemistry, Kyoto University, Kyoto 606–01, Japan', 'institution_ids': ['https://openalex.org/I22299242']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5104068133', 'display_name': 'Toshio Fujita', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I22299242', 'display_name': 'Kyoto University', 'ror': 'https://ror.org/02kpeqv85', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I22299242']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Toshio Fujita', 'raw_affiliation_strings': ['Department of Agricultural Chemistry, Kyoto University, Kyoto 606–01, Japan'], 'affiliations': [{'raw_affiliation_string': 'Department of Agricultural Chemistry, Kyoto University, Kyoto 606–01, Japan', 'institution_ids': ['https://openalex.org/I22299242']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5052860008', 'display_name': 'Kazuo Mochida', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I169016828', 'display_name': 'Shimane University', 'ror': 'https://ror.org/01jaaym28', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I169016828']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Kazuo Mochida', 'raw_affiliation_strings': ['Department of Life Science and Biotechnology, Shimane University, Matsue, Shimane 690, Japan'], 'affiliations': [{'raw_affiliation_string': 'Department of Life Science and Biotechnology, Shimane University, Matsue, Shimane 690, Japan', 'institution_ids': ['https://openalex.org/I169016828']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5069945494', 'display_name': 'Toshiie Nakamura', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I169016828', 'display_name': 'Shimane University', 'ror': 'https://ror.org/01jaaym28', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I169016828']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Toshiie Nakamura', 'raw_affiliation_strings': ['Department of Life Science and Biotechnology, Shimane University, Matsue, Shimane 690, Japan'], 'affiliations': [{'raw_affiliation_string': 'Department of Life Science and Biotechnology, Shimane University, Matsue, Shimane 690, Japan', 'institution_ids': ['https://openalex.org/I169016828']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5031346152', 'display_name': 'Fumio Matsumura', 'orcid': 'https://orcid.org/0000-0002-8204-153X'}, 'institutions': [{'id': 'https://openalex.org/I84218800', 'display_name': 'University of California, Davis', 'ror': 'https://ror.org/05rrcem69', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I84218800']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Fumio Matsumura', 'raw_affiliation_strings': ['Department of Environmental Toxicology and Department of Entomology, University of California, Davis, California 95616, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Environmental Toxicology and Department of Entomology, University of California, Davis, California 95616, USA', 'institution_ids': ['https://openalex.org/I84218800']}]}], 'institution_assertions': [], 'countries_distinct_count': 2, 'institutions_distinct_count': 3, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 6.762, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 29, 'citation_normalized_percentile': {'value': 0.788897, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 87, 'max': 88}, 'biblio': {'volume': '49', 'issue': '4', 'first_page': '319', 'last_page': '332'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11641', 'display_name': 'Insect and Pesticide Research', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/1109', 'display_name': 'Insect Science'}, 'field': {'id': 'https://openalex.org/fields/11', 'display_name': 'Agricultural and Biological Sciences'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11641', 'display_name': 'Insect and Pesticide Research', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/1109', 'display_name': 'Insect Science'}, 'field': {'id': 'https://openalex.org/fields/11', 'display_name': 'Agricultural and Biological Sciences'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10211', 'display_name': 'Computational Drug Discovery Methods', 'score': 0.9876, 'subfield': {'id': 'https://openalex.org/subfields/1703', 'display_name': 'Computational Theory and Mathematics'}, 'field': {'id': 'https://openalex.org/fields/17', 'display_name': 'Computer Science'}, 'domain': {'id': 'https://openalex.org/domains/3', 'display_name': 'Physical Sciences'}}, {'id': 'https://openalex.org/T13454', 'display_name': 'Phenothiazines and Benzothiazines Synthesis and Activities', 'score': 0.9866, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/housefly', 'display_name': 'Housefly', 'score': 0.46726292}, {'id': 'https://openalex.org/keywords/molecular-model', 'display_name': 'Molecular model', 'score': 0.4567609}, {'id': 'https://openalex.org/keywords/structure–activity-relationship', 'display_name': 'Structure–activity relationship', 'score': 0.42731342}], 'concepts': [{'id': 'https://openalex.org/C71240020', 'wikidata': 'https://www.wikidata.org/wiki/Q186011', 'display_name': 'Stereochemistry', 'level': 1, 'score': 0.76359725}, {'id': 'https://openalex.org/C201194858', 'wikidata': 'https://www.wikidata.org/wiki/Q898238', 'display_name': 'Steric effects', 'level': 2, 'score': 0.7465019}, {'id': 'https://openalex.org/C164126121', 'wikidata': 'https://www.wikidata.org/wiki/Q766383', 'display_name': 'Quantitative structure–activity relationship', 'level': 2, 'score': 0.7435897}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.6608868}, {'id': 'https://openalex.org/C107824862', 'wikidata': 'https://www.wikidata.org/wiki/Q616005', 'display_name': 'Binding site', 'level': 2, 'score': 0.5710503}, {'id': 'https://openalex.org/C2779963888', 'wikidata': 'https://www.wikidata.org/wiki/Q166111', 'display_name': 'Housefly', 'level': 4, 'score': 0.46726292}, {'id': 'https://openalex.org/C178910836', 'wikidata': 'https://www.wikidata.org/wiki/Q2196961', 'display_name': 'Molecular model', 'level': 2, 'score': 0.4567609}, {'id': 'https://openalex.org/C41625074', 'wikidata': 'https://www.wikidata.org/wiki/Q176088', 'display_name': 'Membrane', 'level': 2, 'score': 0.4383752}, {'id': 'https://openalex.org/C193042331', 'wikidata': 'https://www.wikidata.org/wiki/Q1772003', 'display_name': 'Structure–activity relationship', 'level': 3, 'score': 0.42731342}, {'id': 'https://openalex.org/C12554922', 'wikidata': 'https://www.wikidata.org/wiki/Q7100', 'display_name': 'Biophysics', 'level': 1, 'score': 0.32180354}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.21979544}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.1960299}, {'id': 'https://openalex.org/C202751555', 'wikidata': 'https://www.wikidata.org/wiki/Q221681', 'display_name': 'In vitro', 'level': 2, 'score': 0.07802585}, {'id': 'https://openalex.org/C59822182', 'wikidata': 'https://www.wikidata.org/wiki/Q441', 'display_name': 'Botany', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C173758957', 'wikidata': 'https://www.wikidata.org/wiki/Q129270', 'display_name': 'Larva', 'level': 2, 'score': 0.0}, {'id': 'https://openalex.org/C182049041', 'wikidata': 'https://www.wikidata.org/wiki/Q10435', 'display_name': 'Musca', 'level': 3, 'score': 0.0}], 'mesh': [], 'locations_count': 1, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1002/(sici)1096-9063(199704)49:4<319::aid-ps537>3.0.co;2-k', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S160044600', 'display_name': 'Pesticide Science', 'issn_l': '0031-613X', 'issn': ['0031-613X', '1096-9063'], 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'score': 0.67, 'display_name': 'Life below water', 'id': 'https://metadata.un.org/sdg/14'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 35, 'referenced_works': ['https://openalex.org/W1569270812', 'https://openalex.org/W1811017971', 'https://openalex.org/W1976106600', 'https://openalex.org/W1976793005', 'https://openalex.org/W1980876268', 'https://openalex.org/W1982026903', 'https://openalex.org/W1984407167', 'https://openalex.org/W1984982646', 'https://openalex.org/W1985699058', 'https://openalex.org/W1995501407', 'https://openalex.org/W2005141413', 'https://openalex.org/W2006930438', 'https://openalex.org/W2015109140', 'https://openalex.org/W2021465324', 'https://openalex.org/W2024351368', 'https://openalex.org/W2035075010', 'https://openalex.org/W2049864926', 'https://openalex.org/W2051239371', 'https://openalex.org/W2063060349', 'https://openalex.org/W2064157831', 'https://openalex.org/W2070062053', 'https://openalex.org/W2071158076', 'https://openalex.org/W2071813789', 'https://openalex.org/W2086124825', 'https://openalex.org/W2088791186', 'https://openalex.org/W2089900405', 'https://openalex.org/W2089962851', 'https://openalex.org/W2127336290', 'https://openalex.org/W2134876647', 'https://openalex.org/W2155358697', 'https://openalex.org/W2315351965', 'https://openalex.org/W2320832779', 'https://openalex.org/W2336261656', 'https://openalex.org/W2506055669', 'https://openalex.org/W598518680'], 'related_works': ['https://openalex.org/W2388872242', 'https://openalex.org/W2387761686', 'https://openalex.org/W2384793995', 'https://openalex.org/W2384393485', 'https://openalex.org/W2376136279', 'https://openalex.org/W2203674469', 'https://openalex.org/W2152912121', 'https://openalex.org/W2151475752', 'https://openalex.org/W2024800145', 'https://openalex.org/W1964962436'], 'abstract_inverted_index': {'Quantitative': [0], 'structure–activity': [1], 'relationships': [2], 'for': [3, 92, 124, 167], 'insecticidal': [4, 101, 120, 159], 'activity': [5, 10, 160], '(against': [6], 'houseflies)': [7], 'and': [8, 31, 84, 102, 143, 182], 'competitive': [9], 'against': [11], 'a': [12, 106, 136, 164], 'specific': [13], '[35S]tert-butylbicyclophosphorothionate': [14], 'binding': [15, 103, 152, 177, 204], '(to': [16], 'rat': [17, 129, 175], 'brain': [18], 'membranes)': [19], 'of': [20, 66, 112, 127, 148, 151, 171, 212], 'some': [21], 'picrotoxinin-type': [22], '4-aminobutyric': [23], 'acid': [24], 'antagonists,': [25], 'including': [26], 'γ-BHC,': [27], 'endosulfan,': [28], 'bicyclophosphates,': [29], 'dioxatricyclododecenes': [30], 'related': [32], 'compounds,': [33, 113, 172], 'were': [34, 45, 90, 193], 'examined': [35], 'three-dimensionally': [36], 'using': [37], 'comparative': [38], 'molecular': [39, 53, 188], 'field': [40], 'analysis': [41], '(CoMFA).': [42], 'The': [43, 76, 180], 'antagonists': [44], 'classified': [46], 'into': [47], 'two': [48], 'series': [49, 94, 141, 189], 'according': [50], 'to': [51, 200], 'their': [52, 57], 'shapes:': [54], 'i.e.': [55], 'whether': [56], 'structure': [58], 'was': [59, 114, 161, 178], "'linearly'": [60], 'extended': [61], 'beyond': [62], 'the': [63, 67, 80, 88, 97, 125, 128, 149, 154, 158, 168, 174, 187, 203, 207], "'mast-head'": [64], 'position': [65], "'boat-like'": [68], 'skeletons': [69], '(series': [70, 74], '1)': [71], 'or': [72], 'not': [73, 123], '2).': [75], 'CoMFA': [77, 192], 'showed': [78], 'that': [79, 133], 'slopes': [81], 'in': [82, 95, 100, 116, 119, 146], 'steric': [83], 'electrostatic': [85], 'fields': [86], 'around': [87], 'molecule': [89], 'significant': [91, 115], 'both': [93], 'governing': [96, 117], 'potency': [98], 'variations': [99, 118], 'activities.': [104], 'Hydrophobicity,': [105], 'possible': [107], 'factor': [108], 'controlling': [109], 'transport': [110], 'behaviour': [111], 'activity,': [121], 'but': [122, 173], 'case': [126], 'membrane': [130, 176], 'binding.': [131], 'Assuming': [132], 'there': [134], 'is': [135], 'slight': [137], 'topological': [138], 'difference': [139], 'between': [140], '1': [142], '2': [144], 'compounds': [145], 'terms': [147], 'mode': [150], 'with': [153, 163, 202], 'housefly': [155], 'receptor': [156], 'site,': [157], 'analysable': [162], 'single': [165], 'equation': [166], 'combined': [169], 'set': [170], 'not.': [179], 'sterically': [181], 'electrostatically': [183], 'favourable': [184], 'regions': [185], 'surrounding': [186], 'indicated': [190], 'by': [191], 'roughly': [194], 'located': [195], 'at': [196], 'positions': [197], 'so': [198], 'as': [199], 'interact': [201], 'subsites': [205], 'on': [206], 'receptors': [208], 'proposed': [209], 'previously.': [210], '©': [211], 'SCI.': [213]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2065722216', 'counts_by_year': [{'year': 2017, 'cited_by_count': 1}, {'year': 2016, 'cited_by_count': 1}, {'year': 2013, 'cited_by_count': 1}], 'updated_date': '2024-12-12T21:30:38.595064', 'created_date': '2016-06-24'}