Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2065716796', 'doi': 'https://doi.org/10.1126/science.6330891', 'title': '<i>Trans</i> -Acting Transcriptional Activation of the Long Terminal Repeat of Human T Lymphotropic Viruses in Infected Cells', 'display_name': '<i>Trans</i> -Acting Transcriptional Activation of the Long Terminal Repeat of Human T Lymphotropic Viruses in Infected Cells', 'publication_year': 1984, 'publication_date': '1984-07-27', 'ids': {'openalex': 'https://openalex.org/W2065716796', 'doi': 'https://doi.org/10.1126/science.6330891', 'mag': '2065716796', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/6330891'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1126/science.6330891', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S3880285', 'display_name': 'Science', 'issn_l': '0036-8075', 'issn': ['0036-8075', '1095-9203'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315823', 'host_organization_name': 'American Association for the Advancement of Science', 'host_organization_lineage': ['https://openalex.org/P4310315823'], 'host_organization_lineage_names': ['American Association for the Advancement of Science'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5071476197', 'display_name': 'Joseph Sodroski', 'orcid': 'https://orcid.org/0000-0002-9750-1615'}, 'institutions': [{'id': 'https://openalex.org/I4210117453', 'display_name': 'Dana-Farber Cancer Institute', 'ror': 'https://ror.org/02jzgtq86', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I4210117453']}, {'id': 'https://openalex.org/I136199984', 'display_name': 'Harvard University', 'ror': 'https://ror.org/03vek6s52', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I136199984']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Joseph G. Sodroski', 'raw_affiliation_strings': ['Dana Farber Cancer Institute, Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115.'], 'affiliations': [{'raw_affiliation_string': 'Dana Farber Cancer Institute, Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115.', 'institution_ids': ['https://openalex.org/I4210117453', 'https://openalex.org/I136199984']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5113492392', 'display_name': 'C A Rosen', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210117453', 'display_name': 'Dana-Farber Cancer Institute', 'ror': 'https://ror.org/02jzgtq86', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I4210117453']}, {'id': 'https://openalex.org/I136199984', 'display_name': 'Harvard University', 'ror': 'https://ror.org/03vek6s52', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I136199984']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Craig A. Rosen', 'raw_affiliation_strings': ['Dana Farber Cancer Institute, Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115.'], 'affiliations': [{'raw_affiliation_string': 'Dana Farber Cancer Institute, Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115.', 'institution_ids': ['https://openalex.org/I4210117453', 'https://openalex.org/I136199984']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5029140036', 'display_name': 'William A. Haseltine', 'orcid': 'https://orcid.org/0000-0003-1567-3702'}, 'institutions': [{'id': 'https://openalex.org/I4210117453', 'display_name': 'Dana-Farber Cancer Institute', 'ror': 'https://ror.org/02jzgtq86', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I4210117453']}, {'id': 'https://openalex.org/I136199984', 'display_name': 'Harvard University', 'ror': 'https://ror.org/03vek6s52', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I136199984']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'William A. Haseltine', 'raw_affiliation_strings': ['Dana Farber Cancer Institute, Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115.', 'Department of Cancer Biology, Harvard School of Public Health, Boston, Massachusetts 02115.'], 'affiliations': [{'raw_affiliation_string': 'Dana Farber Cancer Institute, Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115.', 'institution_ids': ['https://openalex.org/I4210117453', 'https://openalex.org/I136199984']}, {'raw_affiliation_string': 'Department of Cancer Biology, Harvard School of Public Health, Boston, Massachusetts 02115.', 'institution_ids': ['https://openalex.org/I136199984']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 2, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 31.382, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 781, 'citation_normalized_percentile': {'value': 0.989895, 'is_in_top_1_percent': False, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 99, 'max': 100}, 'biblio': {'volume': '225', 'issue': '4660', 'first_page': '381', 'last_page': '385'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T12159', 'display_name': 'T-cell and Retrovirus Studies', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2403', 'display_name': 'Immunology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T12159', 'display_name': 'T-cell and Retrovirus Studies', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2403', 'display_name': 'Immunology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11560', 'display_name': 'Animal Disease Management and Epidemiology', 'score': 0.9871, 'subfield': {'id': 'https://openalex.org/subfields/1102', 'display_name': 'Agronomy and Crop Science'}, 'field': {'id': 'https://openalex.org/fields/11', 'display_name': 'Agricultural and Biological Sciences'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T12733', 'display_name': 'Vector-Borne Animal Diseases', 'score': 0.9816, 'subfield': {'id': 'https://openalex.org/subfields/1105', 'display_name': 'Ecology, Evolution, Behavior and Systematics'}, 'field': {'id': 'https://openalex.org/fields/11', 'display_name': 'Agricultural and Biological Sciences'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/provirus', 'display_name': 'Provirus', 'score': 0.90473783}, {'id': 'https://openalex.org/keywords/transcription', 'display_name': 'Transcription', 'score': 0.53174865}, {'id': 'https://openalex.org/keywords/human-t-lymphotropic-virus', 'display_name': 'Human T-lymphotropic virus', 'score': 0.5076901}, {'id': 'https://openalex.org/keywords/trans-acting', 'display_name': 'Trans-acting', 'score': 0.42495024}, {'id': 'https://openalex.org/keywords/endogenous-retrovirus', 'display_name': 'Endogenous retrovirus', 'score': 0.4129569}], 'concepts': [{'id': 'https://openalex.org/C199491388', 'wikidata': 'https://www.wikidata.org/wiki/Q1869477', 'display_name': 'Long terminal repeat', 'level': 4, 'score': 0.90556717}, {'id': 'https://openalex.org/C102906071', 'wikidata': 'https://www.wikidata.org/wiki/Q422467', 'display_name': 'Provirus', 'level': 4, 'score': 0.90473783}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.7429721}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.5644741}, {'id': 'https://openalex.org/C179926584', 'wikidata': 'https://www.wikidata.org/wiki/Q207714', 'display_name': 'Transcription (linguistics)', 'level': 2, 'score': 0.53174865}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.52387923}, {'id': 'https://openalex.org/C2776368728', 'wikidata': 'https://www.wikidata.org/wiki/Q12258832', 'display_name': 'Human T-lymphotropic virus', 'level': 4, 'score': 0.5076901}, {'id': 'https://openalex.org/C159047783', 'wikidata': 'https://www.wikidata.org/wiki/Q7215', 'display_name': 'Virology', 'level': 1, 'score': 0.4890388}, {'id': 'https://openalex.org/C2522874641', 'wikidata': 'https://www.wikidata.org/wiki/Q808', 'display_name': 'Virus', 'level': 2, 'score': 0.43103027}, {'id': 'https://openalex.org/C53479859', 'wikidata': 'https://www.wikidata.org/wiki/Q3064200', 'display_name': 'Trans-acting', 'level': 4, 'score': 0.42495024}, {'id': 'https://openalex.org/C121346293', 'wikidata': 'https://www.wikidata.org/wiki/Q1340715', 'display_name': 'Endogenous retrovirus', 'level': 4, 'score': 0.4129569}, {'id': 'https://openalex.org/C127716648', 'wikidata': 'https://www.wikidata.org/wiki/Q104053', 'display_name': 'Phenotype', 'level': 3, 'score': 0.41043755}, {'id': 'https://openalex.org/C150194340', 'wikidata': 'https://www.wikidata.org/wiki/Q26972', 'display_name': 'Gene expression', 'level': 3, 'score': 0.31311285}, {'id': 'https://openalex.org/C141231307', 'wikidata': 'https://www.wikidata.org/wiki/Q7020', 'display_name': 'Genome', 'level': 3, 'score': 0.18644646}, {'id': 'https://openalex.org/C41895202', 'wikidata': 'https://www.wikidata.org/wiki/Q8162', 'display_name': 'Linguistics', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C138885662', 'wikidata': 'https://www.wikidata.org/wiki/Q5891', 'display_name': 'Philosophy', 'level': 0, 'score': 0.0}, {'id': 'https://openalex.org/C2777604421', 'wikidata': 'https://www.wikidata.org/wiki/Q2303951', 'display_name': 'Myelopathy', 'level': 3, 'score': 0.0}, {'id': 'https://openalex.org/C169760540', 'wikidata': 'https://www.wikidata.org/wiki/Q207011', 'display_name': 'Neuroscience', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C2780775167', 'wikidata': 'https://www.wikidata.org/wiki/Q9606', 'display_name': 'Spinal cord', 'level': 2, 'score': 0.0}, {'id': 'https://openalex.org/C143065580', 'wikidata': 'https://www.wikidata.org/wiki/Q3285695', 'display_name': 'Mutant', 'level': 3, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D017977', 'descriptor_name': 'Deltaretrovirus', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D012091', 'descriptor_name': 'Repetitive Sequences, Nucleic Acid', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D012192', 'descriptor_name': 'Retroviridae Infections', 'qualifier_ui': 'Q000382', 'qualifier_name': 'microbiology', 'is_major_topic': True}, {'descriptor_ui': 'D014158', 'descriptor_name': 'Transcription, Genetic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D014775', 'descriptor_name': 'Virus Activation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D002471', 'descriptor_name': 'Cell Transformation, Neoplastic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002471', 'descriptor_name': 'Cell Transformation, Neoplastic', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D002472', 'descriptor_name': 'Cell Transformation, Viral', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017977', 'descriptor_name': 'Deltaretrovirus', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017977', 'descriptor_name': 'Deltaretrovirus', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012367', 'descriptor_name': 'RNA, Viral', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D012367', 'descriptor_name': 'RNA, Viral', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D012367', 'descriptor_name': 'RNA, Viral', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012192', 'descriptor_name': 'Retroviridae Infections', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013601', 'descriptor_name': 'T-Lymphocytes', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013601', 'descriptor_name': 'T-Lymphocytes', 'qualifier_ui': 'Q000382', 'qualifier_name': 'microbiology', 'is_major_topic': False}, {'descriptor_ui': 'D014162', 'descriptor_name': 'Transfection', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1126/science.6330891', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S3880285', 'display_name': 'Science', 'issn_l': '0036-8075', 'issn': ['0036-8075', '1095-9203'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315823', 'host_organization_name': 'American Association for the Advancement of Science', 'host_organization_lineage': ['https://openalex.org/P4310315823'], 'host_organization_lineage_names': ['American Association for the Advancement of Science'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/6330891', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/3', 'score': 0.61, 'display_name': 'Good health and well-being'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 52, 'referenced_works': ['https://openalex.org/W1965372133', 'https://openalex.org/W1968873679', 'https://openalex.org/W1970634297', 'https://openalex.org/W1973331161', 'https://openalex.org/W1973430331', 'https://openalex.org/W1975479157', 'https://openalex.org/W1975997182', 'https://openalex.org/W1979637191', 'https://openalex.org/W1981906666', 'https://openalex.org/W1987975025', 'https://openalex.org/W1990998019', 'https://openalex.org/W1991670386', 'https://openalex.org/W2002489933', 'https://openalex.org/W2004291887', 'https://openalex.org/W2005151493', 'https://openalex.org/W2010356985', 'https://openalex.org/W2012704007', 'https://openalex.org/W2015639517', 'https://openalex.org/W2016534065', 'https://openalex.org/W2017190280', 'https://openalex.org/W2018926092', 'https://openalex.org/W2028136882', 'https://openalex.org/W2029366204', 'https://openalex.org/W2032258076', 'https://openalex.org/W2038218774', 'https://openalex.org/W2038882077', 'https://openalex.org/W2043015697', 'https://openalex.org/W2044349616', 'https://openalex.org/W2046273618', 'https://openalex.org/W2047814541', 'https://openalex.org/W2052050039', 'https://openalex.org/W2053956877', 'https://openalex.org/W2056067293', 'https://openalex.org/W2058350611', 'https://openalex.org/W2058795593', 'https://openalex.org/W2060880451', 'https://openalex.org/W2061102119', 'https://openalex.org/W2061311391', 'https://openalex.org/W2066106786', 'https://openalex.org/W2070208938', 'https://openalex.org/W2077077811', 'https://openalex.org/W2083577304', 'https://openalex.org/W2084283756', 'https://openalex.org/W2086143621', 'https://openalex.org/W2089039662', 'https://openalex.org/W2094703003', 'https://openalex.org/W2123679031', 'https://openalex.org/W2136021515', 'https://openalex.org/W2144206181', 'https://openalex.org/W2169413646', 'https://openalex.org/W2416092418', 'https://openalex.org/W3216705818'], 'related_works': ['https://openalex.org/W4376573515', 'https://openalex.org/W4255342245', 'https://openalex.org/W2431653593', 'https://openalex.org/W2399583655', 'https://openalex.org/W2323525443', 'https://openalex.org/W1997923723', 'https://openalex.org/W1960355296', 'https://openalex.org/W1812989076', 'https://openalex.org/W1653376338', 'https://openalex.org/W1486394363'], 'abstract_inverted_index': {'The': [0], 'transcription': [1], 'initiation': [2], 'signals': [3], 'for': [4, 89], 'retroviruses': [5], 'lie': [6], 'within': [7], 'the': [8, 16, 44, 91], 'long': [9], 'terminal': [10], 'repeat': [11], '(LTR)': [12], 'sequences': [13, 48, 80], 'that': [14, 39, 65], 'flank': [15], 'integrated': [17], 'provirus.': [18], 'Two': [19], 'subtypes': [20, 51], 'of': [21, 46, 49, 95], 'human': [22], 'T': [23], 'lymphotropic': [24], 'virus': [25], '(HTLV)': [26], 'are': [27], 'associated': [28], 'with': [29], 'different': [30], 'disease': [31], 'phenotypes.': [32], 'In': [33], 'this': [34], 'article': [35], 'it': [36], 'is': [37, 62], 'shown': [38, 64], 'marked': [40], 'differences': [41], 'exist': [42], 'in': [43, 57, 70, 81], 'ability': [45], 'LTR': [47, 79], 'these': [50, 78], 'to': [52], 'function': [53], 'as': [54], 'transcriptional': [55], 'elements': [56], 'differentiated': [58], 'cell': [59], 'types.': [60], 'It': [61], 'also': [63], 'trans-acting': [66], 'regulatory': [67], 'factors': [68], 'present': [69], 'HTLV-infected': [71], 'cells': [72], 'stimulate': [73], 'gene': [74], 'expression': [75], 'directed': [76], 'by': [77], 'a': [82], 'type-specific': [83], 'manner.': [84], 'These': [85], 'results': [86], 'have': [87], 'implications': [88], 'understanding': [90], 'diverse': [92], 'biological': [93], 'effects': [94], 'HTLV': [96], 'infection.': [97]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2065716796', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2023, 'cited_by_count': 1}, {'year': 2022, 'cited_by_count': 3}, {'year': 2021, 'cited_by_count': 2}, {'year': 2020, 'cited_by_count': 3}, {'year': 2017, 'cited_by_count': 4}, {'year': 2016, 'cited_by_count': 2}, {'year': 2015, 'cited_by_count': 3}, {'year': 2014, 'cited_by_count': 1}, {'year': 2013, 'cited_by_count': 4}, {'year': 2012, 'cited_by_count': 2}], 'updated_date': '2024-12-11T08:45:16.366247', 'created_date': '2016-06-24'}