Title: Prefrontal unit activity during delayed conditional Go/No-go discrimination in the monkey. II. Relation to Go and No-go responses
Abstract: Three monkeys were trained to perform a Go/No-go discrimination task where the animals were required to perform a muscular movement (Go) or to withhold it (No-go) depending on the previously presented signal. Single unit activity was recorded from the prefrontal cortex during the performance of the task. Among 512 task-related prefrontal units, 253 units showed differential activity in relation to the type of the trial (Go or No-go) either at the time of the response or both during the preparatory period for the response and at the time of the response. These units were classified into 3 types depending on whether the changes in unit activity were observed selectively on Go trials (Go units, n= 47), or selectively on No-go trials (No-go units, n= 28) or on both Go and No-go trials (Go/No-go units, n= 178). A small number of units from the premotor cortex (n= 31) were examined inadvertently and the 3 types of units were present in this area as well. The existence of the 3 types of prefrontal units (Go, No-go and Go/No-go) indicates that the prefrontal cortex is involved in the behavioral inhibitory mechanism besides participating in the behavioral excitatory mechanism.
Publication Year: 1986
Publication Date: 1986-09-01
Language: en
Type: article
Indexed In: ['crossref', 'pubmed']
Access and Citation
Cited By Count: 131
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