Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2065295812', 'doi': 'https://doi.org/10.1002/cyto.a.20433', 'title': 'Novel use of the fluorescent dye 5‐(and‐6)‐chloromethyl SNARF‐1 acetate for the measurement of intracellular glutathione in leukemic cells and primary lymphocytes', 'display_name': 'Novel use of the fluorescent dye 5‐(and‐6)‐chloromethyl SNARF‐1 acetate for the measurement of intracellular glutathione in leukemic cells and primary lymphocytes', 'publication_year': 2007, 'publication_date': '2007-07-10', 'ids': {'openalex': 'https://openalex.org/W2065295812', 'doi': 'https://doi.org/10.1002/cyto.a.20433', 'mag': '2065295812', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/17623874'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1002/cyto.a.20433', 'pdf_url': 'https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/cyto.a.20433', 'source': {'id': 'https://openalex.org/S86468533', 'display_name': 'Cytometry Part A', 'issn_l': '1552-4922', 'issn': ['1552-4922', '1552-4930'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'bronze', 'oa_url': 'https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/cyto.a.20433', 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5082013090', 'display_name': 'David P. Hamilton', 'orcid': 'https://orcid.org/0000-0002-9341-8777'}, 'institutions': [{'id': 'https://openalex.org/I5023651', 'display_name': 'McGill University', 'ror': 'https://ror.org/01pxwe438', 'country_code': 'CA', 'type': 'education', 'lineage': ['https://openalex.org/I5023651']}], 'countries': ['CA'], 'is_corresponding': False, 'raw_author_name': 'David Hamilton', 'raw_affiliation_strings': ['Department of Pharmacology and Therapeutics, The Montreal Center for Experimental Therapeutics in Cancer, Lady Davis Institute for Medical Research, Sir Mortimer B. Davis-Jewish General Hospital, McGill University, Montreal, Quebec, Canada.'], 'affiliations': [{'raw_affiliation_string': 'Department of Pharmacology and Therapeutics, The Montreal Center for Experimental Therapeutics in Cancer, Lady Davis Institute for Medical Research, Sir Mortimer B. Davis-Jewish General Hospital, McGill University, Montreal, Quebec, Canada.', 'institution_ids': ['https://openalex.org/I5023651']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5069051267', 'display_name': 'Martin Loignon', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I5023651', 'display_name': 'McGill University', 'ror': 'https://ror.org/01pxwe438', 'country_code': 'CA', 'type': 'education', 'lineage': ['https://openalex.org/I5023651']}], 'countries': ['CA'], 'is_corresponding': False, 'raw_author_name': 'Martin Loignon', 'raw_affiliation_strings': ['McGill University, Montreal, Canada'], 'affiliations': [{'raw_affiliation_string': 'McGill University, Montreal, Canada', 'institution_ids': ['https://openalex.org/I5023651']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5050326141', 'display_name': 'Moulay A. Alaoui‐Jamali', 'orcid': 'https://orcid.org/0000-0002-7824-4190'}, 'institutions': [{'id': 'https://openalex.org/I5023651', 'display_name': 'McGill University', 'ror': 'https://ror.org/01pxwe438', 'country_code': 'CA', 'type': 'education', 'lineage': ['https://openalex.org/I5023651']}], 'countries': ['CA'], 'is_corresponding': False, 'raw_author_name': 'Moulay A. Alaoui‐Jamali', 'raw_affiliation_strings': ['McGill University, Montreal, Canada'], 'affiliations': [{'raw_affiliation_string': 'McGill University, Montreal, Canada', 'institution_ids': ['https://openalex.org/I5023651']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5029097581', 'display_name': 'Gerald Batist', 'orcid': 'https://orcid.org/0000-0001-5430-3750'}, 'institutions': [{'id': 'https://openalex.org/I2801824472', 'display_name': 'Jewish General Hospital', 'ror': 'https://ror.org/056jjra10', 'country_code': 'CA', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2801824472']}, {'id': 'https://openalex.org/I5023651', 'display_name': 'McGill University', 'ror': 'https://ror.org/01pxwe438', 'country_code': 'CA', 'type': 'education', 'lineage': ['https://openalex.org/I5023651']}], 'countries': ['CA'], 'is_corresponding': False, 'raw_author_name': 'Gerald Batist', 'raw_affiliation_strings': ['McGill University, Montreal, Canada', 'The Montreal Center for Experimental Therapeutics in Cancer, The Sir Mortimer B. Davis‐Jewish General Hospital, 3755 Cote Street, Catherine, Montreal, Quebec, Canada H3T‐1E2'], 'affiliations': [{'raw_affiliation_string': 'The Montreal Center for Experimental Therapeutics in Cancer, The Sir Mortimer B. Davis‐Jewish General Hospital, 3755 Cote Street, Catherine, Montreal, Quebec, Canada H3T‐1E2', 'institution_ids': ['https://openalex.org/I2801824472']}, {'raw_affiliation_string': 'McGill University, Montreal, Canada', 'institution_ids': ['https://openalex.org/I5023651']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 2, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 3350, 'currency': 'USD', 'value_usd': 3350, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 0.207, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 7, 'citation_normalized_percentile': {'value': 0.654672, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 80, 'max': 81}, 'biblio': {'volume': '71A', 'issue': '9', 'first_page': '709', 'last_page': '715'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11481', 'display_name': 'Sulfur Compounds in Biology', 'score': 0.9994, 'subfield': {'id': 'https://openalex.org/subfields/1303', 'display_name': 'Biochemistry'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11481', 'display_name': 'Sulfur Compounds in Biology', 'score': 0.9994, 'subfield': {'id': 'https://openalex.org/subfields/1303', 'display_name': 'Biochemistry'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T12187', 'display_name': 'Glutathione Transferases and Polymorphisms', 'score': 0.9994, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10269', 'display_name': 'Epigenetics and DNA Methylation', 'score': 0.9934, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/buthionine-sulfoximine', 'display_name': 'Buthionine sulfoximine', 'score': 0.7899171}, {'id': 'https://openalex.org/keywords/thiol', 'display_name': 'Thiol', 'score': 0.52045774}], 'concepts': [{'id': 'https://openalex.org/C538909803', 'wikidata': 'https://www.wikidata.org/wiki/Q116907', 'display_name': 'Glutathione', 'level': 3, 'score': 0.9617844}, {'id': 'https://openalex.org/C2777476445', 'wikidata': 'https://www.wikidata.org/wiki/Q5002519', 'display_name': 'Buthionine sulfoximine', 'level': 4, 'score': 0.7899171}, {'id': 'https://openalex.org/C79879829', 'wikidata': 'https://www.wikidata.org/wiki/Q5571762', 'display_name': 'Intracellular', 'level': 2, 'score': 0.64840806}, {'id': 'https://openalex.org/C553184892', 'wikidata': 'https://www.wikidata.org/wiki/Q1141429', 'display_name': 'Flow cytometry', 'level': 2, 'score': 0.6480031}, {'id': 'https://openalex.org/C91881484', 'wikidata': 'https://www.wikidata.org/wiki/Q191807', 'display_name': 'Fluorescence', 'level': 2, 'score': 0.5377799}, {'id': 'https://openalex.org/C2776151105', 'wikidata': 'https://www.wikidata.org/wiki/Q898814', 'display_name': 'Oxidative stress', 'level': 2, 'score': 0.53510743}, {'id': 'https://openalex.org/C2781324293', 'wikidata': 'https://www.wikidata.org/wiki/Q220410', 'display_name': 'Thiol', 'level': 2, 'score': 0.52045774}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.4900976}, {'id': 'https://openalex.org/C2777847592', 'wikidata': 'https://www.wikidata.org/wiki/Q375613', 'display_name': 'Acetylcysteine', 'level': 3, 'score': 0.4818979}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.41161567}, {'id': 'https://openalex.org/C153911025', 'wikidata': 'https://www.wikidata.org/wiki/Q7202', 'display_name': 'Molecular biology', 'level': 1, 'score': 0.3330093}, {'id': 'https://openalex.org/C98274493', 'wikidata': 'https://www.wikidata.org/wiki/Q128406', 'display_name': 'Pharmacology', 'level': 1, 'score': 0.32958788}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.32094082}, {'id': 'https://openalex.org/C2778004101', 'wikidata': 'https://www.wikidata.org/wiki/Q133948', 'display_name': 'Antioxidant', 'level': 2, 'score': 0.12078884}, {'id': 'https://openalex.org/C181199279', 'wikidata': 'https://www.wikidata.org/wiki/Q8047', 'display_name': 'Enzyme', 'level': 2, 'score': 0.084929496}, {'id': 'https://openalex.org/C121332964', 'wikidata': 'https://www.wikidata.org/wiki/Q413', 'display_name': 'Physics', 'level': 0, 'score': 0.0}, {'id': 'https://openalex.org/C62520636', 'wikidata': 'https://www.wikidata.org/wiki/Q944', 'display_name': 'Quantum mechanics', 'level': 1, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D001578', 'descriptor_name': 'Benzopyrans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D005434', 'descriptor_name': 'Flow Cytometry', 'qualifier_ui': 'Q000379', 'qualifier_name': 'methods', 'is_major_topic': True}, {'descriptor_ui': 'D005978', 'descriptor_name': 'Glutathione', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D008214', 'descriptor_name': 'Lymphocytes', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D009284', 'descriptor_name': 'Naphthols', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D012235', 'descriptor_name': 'Rhodamines', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D000111', 'descriptor_name': 'Acetylcysteine', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D000111', 'descriptor_name': 'Acetylcysteine', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019328', 'descriptor_name': 'Buthionine Sulfoximine', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D019328', 'descriptor_name': 'Buthionine Sulfoximine', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D045744', 'descriptor_name': 'Cell Line, Tumor', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D003958', 'descriptor_name': 'Diamide', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D003958', 'descriptor_name': 'Diamide', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005434', 'descriptor_name': 'Flow Cytometry', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005456', 'descriptor_name': 'Fluorescent Dyes', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005978', 'descriptor_name': 'Glutathione', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019169', 'descriptor_name': 'Jurkat Cells', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008214', 'descriptor_name': 'Lymphocytes', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1002/cyto.a.20433', 'pdf_url': 'https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/cyto.a.20433', 'source': {'id': 'https://openalex.org/S86468533', 'display_name': 'Cytometry Part A', 'issn_l': '1552-4922', 'issn': ['1552-4922', '1552-4930'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/17623874', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1002/cyto.a.20433', 'pdf_url': 'https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/cyto.a.20433', 'source': {'id': 'https://openalex.org/S86468533', 'display_name': 'Cytometry Part A', 'issn_l': '1552-4922', 'issn': ['1552-4922', '1552-4930'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'score': 0.7, 'display_name': 'Good health and well-being', 'id': 'https://metadata.un.org/sdg/3'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 36, 'referenced_works': ['https://openalex.org/W1563653502', 'https://openalex.org/W1594684968', 'https://openalex.org/W1611919433', 'https://openalex.org/W1940169030', 'https://openalex.org/W1967801053', 'https://openalex.org/W1970680007', 'https://openalex.org/W1972847732', 'https://openalex.org/W1976346227', 'https://openalex.org/W1982322754', 'https://openalex.org/W1989394936', 'https://openalex.org/W1992431983', 'https://openalex.org/W2003706186', 'https://openalex.org/W2004607521', 'https://openalex.org/W2007064404', 'https://openalex.org/W2009082798', 'https://openalex.org/W2047685803', 'https://openalex.org/W2048563316', 'https://openalex.org/W2053162975', 'https://openalex.org/W2054939281', 'https://openalex.org/W2062010950', 'https://openalex.org/W2062927875', 'https://openalex.org/W2065463296', 'https://openalex.org/W2067929856', 'https://openalex.org/W2070862685', 'https://openalex.org/W2071756286', 'https://openalex.org/W2085826212', 'https://openalex.org/W2087312091', 'https://openalex.org/W2088216681', 'https://openalex.org/W2095843353', 'https://openalex.org/W2111150708', 'https://openalex.org/W2139686367', 'https://openalex.org/W2144361706', 'https://openalex.org/W2150081412', 'https://openalex.org/W2187177193', 'https://openalex.org/W4229622461', 'https://openalex.org/W561754329'], 'related_works': ['https://openalex.org/W2122325434', 'https://openalex.org/W2095289053', 'https://openalex.org/W2050112629', 'https://openalex.org/W2036898700', 'https://openalex.org/W2024018261', 'https://openalex.org/W1983480912', 'https://openalex.org/W1979168452', 'https://openalex.org/W1851113781', 'https://openalex.org/W1664552158', 'https://openalex.org/W1601942384'], 'abstract_inverted_index': {'Abstract': [0], 'Glutathione': [1], '(GSH)': [2], 'plays': [3], 'an': [4], 'important': [5], 'role': [6], 'in': [7, 17, 26, 43, 61, 67, 77, 128, 133, 183, 186], 'protecting': [8], 'cells': [9, 100], 'against': [10], 'injury,': [11], 'particularly': [12], 'during': [13], 'oxidative': [14], 'stress.': [15], 'Alterations': [16], 'GSH': [18, 41, 68, 75, 116, 129, 138, 150, 165, 184], 'metabolism': [19], 'are': [20], 'becoming': [21], 'the': [22, 53, 56, 187], 'focus': [23], 'of': [24, 40, 48, 55, 145, 189], 'attention': [25], 'many': [27], 'diseases': [28], 'such': [29], 'as': [30], 'cancer,': [31], 'neurodegeneration,': [32], 'and': [33, 80, 103, 130, 153, 167, 178], 'AIDS.': [34], 'As': [35], 'such,': [36], 'a': [37, 44, 71, 118, 124, 142], 'rapid': [38], 'assessment': [39], 'levels': [42, 76, 151], 'clinical': [45], 'setting': [46], 'is': [47], 'increasing': [49], 'importance.': [50], 'We': [51], 'tested': [52], 'efficacy': [54], 'thiol‐labeling': [57], 'fluorescent': [58], 'dye': [59], 'CM‐SNARF': [60, 107, 172], 'its': [62], 'ability': [63], 'to': [64, 141, 176], 'measure': [65], 'variations': [66, 182], 'concentration': [69, 166, 185], 'using': [70, 117], 'visible‐light': [72], 'flow': [73, 110], 'cytometer.': [74], 'I83,': [78], 'Jurkat,': [79], 'primary': [81], 'lymphocytes': [82], 'were': [83, 101], 'depleted': [84, 137], 'with': [85, 93, 106], 'buthionine': [86], 'sulfoximine': [87], '(BSO)': [88], 'or': [89, 91, 113], 'diamide,': [90], 'increased': [92, 149], 'N': [94], '‐acetylcysteine': [95], '(NAC).': [96], 'Following': [97], 'each': [98], 'treatment,': [99], 'divided': [102], 'either': [104], 'labeled': [105], 'followed': [108], 'by': [109], 'cytometry': [111], 'analysis,': [112], 'assayed': [114], 'for': [115, 198], 'biochemical': [119], 'method.': [120], 'BSO': [121], 'treatment': [122, 148], 'caused': [123], 'maximal': [125], '87–90%': [126], 'decrease': [127, 132, 144], '68–76%': [131], 'fluorescence': [134, 143, 154, 169], 'units.': [135], 'Diamide': [136], '91–95%,': [139], 'corresponding': [140], '85–88%.': [146], 'NAC': [147], '27%': [152], '12–19%.': [155], 'The': [156], 'overall': [157], 'correlation': [158], '(': [159], 'R': [160], '2': [161], ')': [162], 'between': [163], 'mean': [164, 168], 'was': [170], '0.80–0.88.': [171], 'can': [173], 'be': [174], 'used': [175], 'semi‐quantitatively': [177], 'rapidly': [179], 'determine': [180], 'intracellular': [181], 'range': [188], '10–150': [190], 'nmoles': [191], 'GSH/mg': [192], 'protein.': [193], '©': [194], '2007': [195], 'International': [196], 'Society': [197], 'Analytical': [199], 'Cytology': [200]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2065295812', 'counts_by_year': [{'year': 2018, 'cited_by_count': 1}, {'year': 2017, 'cited_by_count': 1}, {'year': 2016, 'cited_by_count': 1}, {'year': 2015, 'cited_by_count': 1}, {'year': 2014, 'cited_by_count': 1}, {'year': 2012, 'cited_by_count': 1}], 'updated_date': '2024-12-09T03:37:40.281495', 'created_date': '2016-06-24'}