Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2065156837', 'doi': 'https://doi.org/10.1016/s0014-4827(03)00126-5', 'title': 'Syndecan-1-mediated cell spreading requires signaling by αvβ3 integrins in human breast carcinoma cells', 'display_name': 'Syndecan-1-mediated cell spreading requires signaling by αvβ3 integrins in human breast carcinoma cells', 'publication_year': 2003, 'publication_date': '2003-06-01', 'ids': {'openalex': 'https://openalex.org/W2065156837', 'doi': 'https://doi.org/10.1016/s0014-4827(03)00126-5', 'mag': '2065156837', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/12749851'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1016/s0014-4827(03)00126-5', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S132505712', 'display_name': 'Experimental Cell Research', 'issn_l': '0014-4827', 'issn': ['0014-4827', '1090-2422'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5071193230', 'display_name': 'DeannaLee M. Beauvais', 'orcid': 'https://orcid.org/0000-0003-4575-1564'}, 'institutions': [{'id': 'https://openalex.org/I135310074', 'display_name': 'University of Wisconsin–Madison', 'ror': 'https://ror.org/01y2jtd41', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I135310074']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'DeannaLee M Beauvais', 'raw_affiliation_strings': ['Department of Pathology and Laboratory Medicine, and Program in Molecular and Cellular Pharmacology, University of Wisconsin-Madison, Madison, WI 53706, USA.'], 'affiliations': [{'raw_affiliation_string': 'Department of Pathology and Laboratory Medicine, and Program in Molecular and Cellular Pharmacology, University of Wisconsin-Madison, Madison, WI 53706, USA.', 'institution_ids': ['https://openalex.org/I135310074']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5084124992', 'display_name': 'Alan C. Rapraeger', 'orcid': 'https://orcid.org/0000-0003-1719-3286'}, 'institutions': [{'id': 'https://openalex.org/I135310074', 'display_name': 'University of Wisconsin–Madison', 'ror': 'https://ror.org/01y2jtd41', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I135310074']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Alan C Rapraeger', 'raw_affiliation_strings': ['Department of Pathology and Laboratory Medicine, and Program in Molecular and Cellular Pharmacology, University of Wisconsin-Madison, Madison, WI 53706, USA.'], 'affiliations': [{'raw_affiliation_string': 'Department of Pathology and Laboratory Medicine, and Program in Molecular and Cellular Pharmacology, University of Wisconsin-Madison, Madison, WI 53706, USA.', 'institution_ids': ['https://openalex.org/I135310074']}]}], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 2910, 'currency': 'USD', 'value_usd': 2910, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 3.295, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 141, 'citation_normalized_percentile': {'value': 0.999812, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 97, 'max': 98}, 'biblio': {'volume': '286', 'issue': '2', 'first_page': '219', 'last_page': '232'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11131', 'display_name': 'Role of Extracellular Matrix in Biological Signaling', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1307', 'display_name': 'Cell Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11131', 'display_name': 'Role of Extracellular Matrix in Biological Signaling', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1307', 'display_name': 'Cell Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10831', 'display_name': 'Integrin Signaling in Inflammation and Cancer', 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/2723', 'display_name': 'Immunology and Allergy'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10620', 'display_name': 'Role of Matrix Metalloproteinases in Cancer and Physiology', 'score': 0.9973, 'subfield': {'id': 'https://openalex.org/subfields/1306', 'display_name': 'Cancer Research'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/ectodomain', 'display_name': 'Ectodomain', 'score': 0.943323}, {'id': 'https://openalex.org/keywords/syndecan-1', 'display_name': 'Syndecan 1', 'score': 0.9143168}, {'id': 'https://openalex.org/keywords/cell-adhesion', 'display_name': 'Cell Adhesion', 'score': 0.553867}, {'id': 'https://openalex.org/keywords/cell-signaling', 'display_name': 'Cell Signaling', 'score': 0.527238}, {'id': 'https://openalex.org/keywords/cd49c', 'display_name': 'CD49c', 'score': 0.4166761}], 'concepts': [{'id': 'https://openalex.org/C1009742', 'wikidata': 'https://www.wikidata.org/wiki/Q5333998', 'display_name': 'Ectodomain', 'level': 3, 'score': 0.943323}, {'id': 'https://openalex.org/C65001120', 'wikidata': 'https://www.wikidata.org/wiki/Q14912913', 'display_name': 'Syndecan 1', 'level': 3, 'score': 0.9143168}, {'id': 'https://openalex.org/C195687474', 'wikidata': 'https://www.wikidata.org/wiki/Q409715', 'display_name': 'Integrin', 'level': 3, 'score': 0.80521953}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.7117944}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.6897329}, {'id': 'https://openalex.org/C85789140', 'wikidata': 'https://www.wikidata.org/wiki/Q187640', 'display_name': 'Cell adhesion', 'level': 3, 'score': 0.5614045}, {'id': 'https://openalex.org/C2778041096', 'wikidata': 'https://www.wikidata.org/wiki/Q424668', 'display_name': 'Heparan sulfate', 'level': 3, 'score': 0.4934796}, {'id': 'https://openalex.org/C62478195', 'wikidata': 'https://www.wikidata.org/wiki/Q828130', 'display_name': 'Signal transduction', 'level': 2, 'score': 0.44228667}, {'id': 'https://openalex.org/C156585808', 'wikidata': 'https://www.wikidata.org/wiki/Q18028043', 'display_name': 'Integrin, beta 6', 'level': 4, 'score': 0.4379296}, {'id': 'https://openalex.org/C4894155', 'wikidata': 'https://www.wikidata.org/wiki/Q4201950', 'display_name': 'CD49c', 'level': 5, 'score': 0.4166761}, {'id': 'https://openalex.org/C1491633281', 'wikidata': 'https://www.wikidata.org/wiki/Q7868', 'display_name': 'Cell', 'level': 2, 'score': 0.36564958}, {'id': 'https://openalex.org/C170493617', 'wikidata': 'https://www.wikidata.org/wiki/Q208467', 'display_name': 'Receptor', 'level': 2, 'score': 0.27817214}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.1994339}], 'mesh': [{'descriptor_ui': 'D001943', 'descriptor_name': 'Breast Neoplasms', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D002448', 'descriptor_name': 'Cell Adhesion', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D002465', 'descriptor_name': 'Cell Movement', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D005057', 'descriptor_name': 'Eukaryotic Cells', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D039302', 'descriptor_name': 'Integrin alphaVbeta3', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D008562', 'descriptor_name': 'Membrane Glycoproteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D011509', 'descriptor_name': 'Proteoglycans', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D001943', 'descriptor_name': 'Breast Neoplasms', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002448', 'descriptor_name': 'Cell Adhesion', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D002448', 'descriptor_name': 'Cell Adhesion', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002465', 'descriptor_name': 'Cell Movement', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D002465', 'descriptor_name': 'Cell Movement', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005057', 'descriptor_name': 'Eukaryotic Cells', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D005057', 'descriptor_name': 'Eukaryotic Cells', 'qualifier_ui': 'Q000166', 'qualifier_name': 'cytology', 'is_major_topic': False}, {'descriptor_ui': 'D005057', 'descriptor_name': 'Eukaryotic Cells', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005260', 'descriptor_name': 'Female', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D039302', 'descriptor_name': 'Integrin alphaVbeta3', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019012', 'descriptor_name': 'Integrin beta1', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D019012', 'descriptor_name': 'Integrin beta1', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019012', 'descriptor_name': 'Integrin beta1', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D039661', 'descriptor_name': 'Integrin beta3', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D039661', 'descriptor_name': 'Integrin beta3', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D039661', 'descriptor_name': 'Integrin beta3', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D008274', 'descriptor_name': 'Magnesium', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008274', 'descriptor_name': 'Magnesium', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D008562', 'descriptor_name': 'Membrane Glycoproteins', 'qualifier_ui': 'Q000037', 'qualifier_name': 'antagonists & inhibitors', 'is_major_topic': False}, {'descriptor_ui': 'D008562', 'descriptor_name': 'Membrane Glycoproteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017434', 'descriptor_name': 'Protein Structure, Tertiary', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D017434', 'descriptor_name': 'Protein Structure, Tertiary', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}, {'descriptor_ui': 'D017434', 'descriptor_name': 'Protein Structure, Tertiary', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011509', 'descriptor_name': 'Proteoglycans', 'qualifier_ui': 'Q000037', 'qualifier_name': 'antagonists & inhibitors', 'is_major_topic': False}, {'descriptor_ui': 'D011509', 'descriptor_name': 'Proteoglycans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015398', 'descriptor_name': 'Signal Transduction', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D015398', 'descriptor_name': 'Signal Transduction', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}, {'descriptor_ui': 'D015398', 'descriptor_name': 'Signal Transduction', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D053668', 'descriptor_name': 'Syndecan-1', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D053671', 'descriptor_name': 'Syndecan-4', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D053667', 'descriptor_name': 'Syndecans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014407', 'descriptor_name': 'Tumor Cells, Cultured', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1016/s0014-4827(03)00126-5', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S132505712', 'display_name': 'Experimental Cell Research', 'issn_l': '0014-4827', 'issn': ['0014-4827', '1090-2422'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/12749851', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 80, 'referenced_works': ['https://openalex.org/W1481596686', 'https://openalex.org/W1487858339', 'https://openalex.org/W1539404498', 'https://openalex.org/W1565494103', 'https://openalex.org/W1566066927', 'https://openalex.org/W1569428681', 'https://openalex.org/W1585648374', 'https://openalex.org/W1586162668', 'https://openalex.org/W1590696423', 'https://openalex.org/W1594207045', 'https://openalex.org/W1604088022', 'https://openalex.org/W1625671034', 'https://openalex.org/W1919621005', 'https://openalex.org/W1931472297', 'https://openalex.org/W1967223154', 'https://openalex.org/W1973064894', 'https://openalex.org/W1977562862', 'https://openalex.org/W1977867890', 'https://openalex.org/W1978708058', 'https://openalex.org/W1982965697', 'https://openalex.org/W1983308906', 'https://openalex.org/W1983426119', 'https://openalex.org/W1984484904', 'https://openalex.org/W1987817886', 'https://openalex.org/W1989046246', 'https://openalex.org/W1991247076', 'https://openalex.org/W1991503015', 'https://openalex.org/W1991708828', 'https://openalex.org/W1993440705', 'https://openalex.org/W1996066976', 'https://openalex.org/W2001752742', 'https://openalex.org/W2001753204', 'https://openalex.org/W2008588224', 'https://openalex.org/W2016391435', 'https://openalex.org/W2024422510', 'https://openalex.org/W2029206521', 'https://openalex.org/W2036510848', 'https://openalex.org/W2041400374', 'https://openalex.org/W2045891730', 'https://openalex.org/W2052447181', 'https://openalex.org/W2058240687', 'https://openalex.org/W2066371830', 'https://openalex.org/W2068365812', 'https://openalex.org/W2069727723', 'https://openalex.org/W2072871114', 'https://openalex.org/W2074086968', 'https://openalex.org/W2077177273', 'https://openalex.org/W2082548786', 'https://openalex.org/W2084664594', 'https://openalex.org/W2085299722', 'https://openalex.org/W2093463437', 'https://openalex.org/W2097509210', 'https://openalex.org/W2098703981', 'https://openalex.org/W2102227752', 'https://openalex.org/W2110416410', 'https://openalex.org/W2111964851', 'https://openalex.org/W2113557771', 'https://openalex.org/W2115554540', 'https://openalex.org/W2122916194', 'https://openalex.org/W2123807445', 'https://openalex.org/W2127670194', 'https://openalex.org/W2132079001', 'https://openalex.org/W2136261162', 'https://openalex.org/W2136644587', 'https://openalex.org/W2136987922', 'https://openalex.org/W2138482225', 'https://openalex.org/W2144328981', 'https://openalex.org/W2155824282', 'https://openalex.org/W2158832664', 'https://openalex.org/W2162312857', 'https://openalex.org/W2169829977', 'https://openalex.org/W2173289516', 'https://openalex.org/W2185801405', 'https://openalex.org/W2286325638', 'https://openalex.org/W2414887581', 'https://openalex.org/W2428136149', 'https://openalex.org/W34966227', 'https://openalex.org/W4244803411', 'https://openalex.org/W4250102918', 'https://openalex.org/W4256717869'], 'related_works': ['https://openalex.org/W4235290343', 'https://openalex.org/W28257182', 'https://openalex.org/W2123128528', 'https://openalex.org/W2122306511', 'https://openalex.org/W2088505684', 'https://openalex.org/W2024921895', 'https://openalex.org/W1997964633', 'https://openalex.org/W1976727749', 'https://openalex.org/W1510886429', 'https://openalex.org/W1484612874'], 'abstract_inverted_index': {'Syndecans': [0], 'are': [1, 28], 'cell': [2, 11, 158], 'surface': [3], 'heparan': [4, 25], 'sulfate': [5, 26], 'proteoglycans': [6], 'with': [7, 100, 149, 189], 'regulatory': [8], 'roles': [9], 'in': [10, 138, 178, 187], 'adhesion,': [12, 47, 159], 'proliferation,': [13], 'and': [14], 'differentiation': [15], '[Annu.': [16], 'Rev.': [17], 'Biochem.': [18], '68': [19], '(1999)': [20], '729].': [21], 'While': [22, 60], 'the': [23, 37, 162, 169, 172, 179], 'syndecan': [24], 'chains': [27], 'essential': [29], 'for': [30], 'matrix': [31], 'binding,': [32], 'less': [33], 'is': [34, 94, 142, 196], 'known': [35], 'about': [36], 'signaling': [38, 183, 192], 'role': [39], 'of': [40, 87, 98, 117, 124, 144, 171, 181], 'their': [41], 'core': [42, 174], 'proteins.': [43], 'To': [44], 'mimic': [45], 'syndecan-specific': [46], 'MDA-MB-231': [48], 'mammary': [49], 'carcinoma': [50], 'cells': [51, 61, 66, 73, 99], 'were': [52], 'plated': [53], 'on': [54], 'antibodies': [55, 113], 'against': [56], 'syndecan-4': [57, 64], 'or': [58, 90], 'syndecan-1.': [59], 'adherent': [62, 67, 74], 'via': [63, 68, 75, 193], 'spread,': [65], 'syndecan-1': [69, 76, 141, 152, 173], 'do': [70], 'not.': [71], 'However,': [72], 'can': [77], 'be': [78], 'induced': [79], 'to': [80, 140], 'spread': [81], 'by': [82, 133, 199], 'Mn2+,': [83], 'suggesting': [84, 115], 'that': [85, 168, 185], 'activation': [86, 127, 131], 'a': [88, 101, 118, 182], 'β1': [89, 103, 111, 125, 200], 'β3': [91], 'integrin': [92, 112, 120, 126, 130], 'partner': [93], 'required.': [95], 'Surprisingly,': [96], 'pretreatment': [97], 'function-activating': [102], 'antibody': [104], 'does': [105, 155], 'not': [106, 156], 'induce': [107], 'spreading,': [108], 'whereas': [109], 'function-blocking': [110], 'do,': [114], 'involvement': [116], 'β1-to-β3': [119], 'cross-talk.': [121], 'Indeed,': [122], 'blockade': [123], 'induces': [128], 'αvβ3': [129, 190], 'detectable': [132], 'soluble': [134, 150], 'fibrinogen': [135], 'binding.': [136, 146], 'Spreading': [137], 'response': [139], 'independent': [143], 'integrin-ligand': [145], 'Furthermore,': [147], 'competition': [148], 'murine': [151], 'ectodomain,': [153], 'which': [154], 'disrupt': [157], 'nonetheless': [160], 'blocks': [161], 'spreading': [163], 'mechanism.': [164], 'These': [165], 'data': [166], 'suggest': [167], 'ectodomain': [170], 'protein': [175], 'directly': [176], 'participates': [177], 'formation': [180], 'complex': [184, 195], 'signals': [186], 'cooperation': [188], 'integrins;': [191], 'this': [194], 'negatively': [197], 'regulated': [198], 'integrins.': [201]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2065156837', 'counts_by_year': [{'year': 2024, 'cited_by_count': 2}, {'year': 2023, 'cited_by_count': 2}, {'year': 2022, 'cited_by_count': 6}, {'year': 2021, 'cited_by_count': 4}, {'year': 2020, 'cited_by_count': 6}, {'year': 2019, 'cited_by_count': 2}, {'year': 2018, 'cited_by_count': 6}, {'year': 2017, 'cited_by_count': 3}, {'year': 2016, 'cited_by_count': 7}, {'year': 2015, 'cited_by_count': 12}, {'year': 2014, 'cited_by_count': 11}, {'year': 2013, 'cited_by_count': 12}, {'year': 2012, 'cited_by_count': 5}], 'updated_date': '2024-08-31T20:51:38.707158', 'created_date': '2016-06-24'}