Title: A view of the relation between carcinogenesis and mutagenesis
Abstract: The somatic mutation theory of cancer causation gained the status of dogma following the demonstration in the 1970s that the majority of carcinogens were mutagens. However, more than a decade of “validation” and experimentation has failed to explain a notable group of noncongruent mutagens and carcinogens. Other evidence, including cases of nonparallel metabolic activation pathways for mutagenesis and carcinogenesis and patterns of organ-specific effects, does not support the somatic mutation theory. Therefore, the mutagenic reactions of carcinogens might be coincidental rather than causal; alternate mechanisms of carcinogenesis should be considered.
Publication Year: 1989
Publication Date: 1989-01-01
Language: en
Type: review
Indexed In: ['crossref', 'pubmed']
Access and Citation
Cited By Count: 43
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