Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2064940611', 'doi': 'https://doi.org/10.1254/jphs.10262fp', 'title': 'Contributions of Hepatic Gluconeogenesis Suppression and Compensative Glycogenolysis on the Glucose-Lowering Effect of CS-917, a Fructose 1,6-Bisphosphatase Inhibitor, in Non-obese Type 2 Diabetes Goto-Kakizaki Rats', 'display_name': 'Contributions of Hepatic Gluconeogenesis Suppression and Compensative Glycogenolysis on the Glucose-Lowering Effect of CS-917, a Fructose 1,6-Bisphosphatase Inhibitor, in Non-obese Type 2 Diabetes Goto-Kakizaki Rats', 'publication_year': 2011, 'publication_date': '2011-01-01', 'ids': {'openalex': 'https://openalex.org/W2064940611', 'doi': 'https://doi.org/10.1254/jphs.10262fp', 'mag': '2064940611', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/21350313'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1254/jphs.10262fp', 'pdf_url': 'https://www.jstage.jst.go.jp/article/jphs/115/3/115_10262FP/_pdf', 'source': {'id': 'https://openalex.org/S163931769', 'display_name': 'Journal of Pharmacological Sciences', 'issn_l': '1347-8613', 'issn': ['1347-8613', '1347-8648'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'bronze', 'oa_url': 'https://www.jstage.jst.go.jp/article/jphs/115/3/115_10262FP/_pdf', 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5103422066', 'display_name': 'Taishi Yoshida', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210104626', 'display_name': 'Daiichi-Sankyo (Japan)', 'ror': 'https://ror.org/027y26122', 'country_code': 'JP', 'type': 'company', 'lineage': ['https://openalex.org/I4210104626']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Taishi Yoshida', 'raw_affiliation_strings': ['Cardiovascular-Metabolics Research Laboratories, R&D Division, Daiichi Sankyo Co., Ltd., Japan'], 'affiliations': [{'raw_affiliation_string': 'Cardiovascular-Metabolics Research Laboratories, R&D Division, Daiichi Sankyo Co., Ltd., Japan', 'institution_ids': ['https://openalex.org/I4210104626']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5110295179', 'display_name': 'Akira Okuno', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210104626', 'display_name': 'Daiichi-Sankyo (Japan)', 'ror': 'https://ror.org/027y26122', 'country_code': 'JP', 'type': 'company', 'lineage': ['https://openalex.org/I4210104626']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Akira Okuno', 'raw_affiliation_strings': ['Cardiovascular-Metabolics Research Laboratories, R&D Division, Daiichi Sankyo Co., Ltd., Japan'], 'affiliations': [{'raw_affiliation_string': 'Cardiovascular-Metabolics Research Laboratories, R&D Division, Daiichi Sankyo Co., Ltd., Japan', 'institution_ids': ['https://openalex.org/I4210104626']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5016038172', 'display_name': 'Kanako Takahashi', 'orcid': 'https://orcid.org/0000-0001-8945-2713'}, 'institutions': [{'id': 'https://openalex.org/I4210104626', 'display_name': 'Daiichi-Sankyo (Japan)', 'ror': 'https://ror.org/027y26122', 'country_code': 'JP', 'type': 'company', 'lineage': ['https://openalex.org/I4210104626']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Kanako Takahashi', 'raw_affiliation_strings': ['Cardiovascular-Metabolics Research Laboratories, R&D Division, Daiichi Sankyo Co., Ltd., Japan'], 'affiliations': [{'raw_affiliation_string': 'Cardiovascular-Metabolics Research Laboratories, R&D Division, Daiichi Sankyo Co., Ltd., Japan', 'institution_ids': ['https://openalex.org/I4210104626']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5110776085', 'display_name': 'Junko Ogawa', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210104626', 'display_name': 'Daiichi-Sankyo (Japan)', 'ror': 'https://ror.org/027y26122', 'country_code': 'JP', 'type': 'company', 'lineage': ['https://openalex.org/I4210104626']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Junko Ogawa', 'raw_affiliation_strings': ['Cardiovascular-Metabolics Research Laboratories, R&D Division, Daiichi Sankyo Co., Ltd., Japan'], 'affiliations': [{'raw_affiliation_string': 'Cardiovascular-Metabolics Research Laboratories, R&D Division, Daiichi Sankyo Co., Ltd., Japan', 'institution_ids': ['https://openalex.org/I4210104626']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5055740171', 'display_name': 'Yuka Hagisawa', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210104626', 'display_name': 'Daiichi-Sankyo (Japan)', 'ror': 'https://ror.org/027y26122', 'country_code': 'JP', 'type': 'company', 'lineage': ['https://openalex.org/I4210104626']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Yuka Hagisawa', 'raw_affiliation_strings': ['Cardiovascular-Metabolics Research Laboratories, R&D Division, Daiichi Sankyo Co., Ltd., Japan'], 'affiliations': [{'raw_affiliation_string': 'Cardiovascular-Metabolics Research Laboratories, R&D Division, Daiichi Sankyo Co., Ltd., Japan', 'institution_ids': ['https://openalex.org/I4210104626']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5014437813', 'display_name': 'Shoichi Kanda', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210104626', 'display_name': 'Daiichi-Sankyo (Japan)', 'ror': 'https://ror.org/027y26122', 'country_code': 'JP', 'type': 'company', 'lineage': ['https://openalex.org/I4210104626']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Shoichi Kanda', 'raw_affiliation_strings': ['Cardiovascular-Metabolics Research Laboratories, R&D Division, Daiichi Sankyo Co., Ltd., Japan'], 'affiliations': [{'raw_affiliation_string': 'Cardiovascular-Metabolics Research Laboratories, R&D Division, Daiichi Sankyo Co., Ltd., Japan', 'institution_ids': ['https://openalex.org/I4210104626']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5105889718', 'display_name': 'Toshihiko Fujiwara', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210104626', 'display_name': 'Daiichi-Sankyo (Japan)', 'ror': 'https://ror.org/027y26122', 'country_code': 'JP', 'type': 'company', 'lineage': ['https://openalex.org/I4210104626']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Toshihiko Fujiwara', 'raw_affiliation_strings': ['R&D Planning Department, R&D Division, Daiichi Sankyo Co., Ltd., Japan'], 'affiliations': [{'raw_affiliation_string': 'R&D Planning Department, R&D Division, Daiichi Sankyo Co., Ltd., Japan', 'institution_ids': ['https://openalex.org/I4210104626']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 100000, 'currency': 'JPY', 'value_usd': 753, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 0.703, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 7, 'citation_normalized_percentile': {'value': 0.70386, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 82, 'max': 83}, 'biblio': {'volume': '115', 'issue': '3', 'first_page': '329', 'last_page': '335'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T12604', 'display_name': 'Glycogen Storage Diseases and Myoclonus', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2745', 'display_name': 'Rheumatology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T12604', 'display_name': 'Glycogen Storage Diseases and Myoclonus', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2745', 'display_name': 'Rheumatology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11339', 'display_name': 'Metabolism, Diabetes, and Cancer', 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T12915', 'display_name': 'Biochemical Acid Research Studies', 'score': 0.9991, 'subfield': {'id': 'https://openalex.org/subfields/1303', 'display_name': 'Biochemistry'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/glycogenolysis', 'display_name': 'Glycogenolysis', 'score': 0.9491022}, {'id': 'https://openalex.org/keywords/gluconeogenesis', 'display_name': 'Gluconeogenesis', 'score': 0.9044987}], 'concepts': [{'id': 'https://openalex.org/C2777949327', 'wikidata': 'https://www.wikidata.org/wiki/Q680603', 'display_name': 'Glycogenolysis', 'level': 3, 'score': 0.9491022}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.92665803}, {'id': 'https://openalex.org/C134018914', 'wikidata': 'https://www.wikidata.org/wiki/Q162606', 'display_name': 'Endocrinology', 'level': 1, 'score': 0.9102137}, {'id': 'https://openalex.org/C20904676', 'wikidata': 'https://www.wikidata.org/wiki/Q191835', 'display_name': 'Gluconeogenesis', 'level': 3, 'score': 0.9044987}, {'id': 'https://openalex.org/C2777499176', 'wikidata': 'https://www.wikidata.org/wiki/Q174936', 'display_name': 'Glycogen', 'level': 2, 'score': 0.75684667}, {'id': 'https://openalex.org/C2776970464', 'wikidata': 'https://www.wikidata.org/wiki/Q122043', 'display_name': 'Fructose', 'level': 2, 'score': 0.56455666}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.54191005}, {'id': 'https://openalex.org/C62231903', 'wikidata': 'https://www.wikidata.org/wiki/Q1057', 'display_name': 'Metabolism', 'level': 2, 'score': 0.27584547}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.27040684}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.17819798}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.11215058}], 'mesh': [{'descriptor_ui': 'D000409', 'descriptor_name': 'Alanine', 'qualifier_ui': 'Q000031', 'qualifier_name': 'analogs & derivatives', 'is_major_topic': True}, {'descriptor_ui': 'D000577', 'descriptor_name': 'Amides', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D001786', 'descriptor_name': 'Blood Glucose', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': True}, {'descriptor_ui': 'D001786', 'descriptor_name': 'Blood Glucose', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D003924', 'descriptor_name': 'Diabetes Mellitus, Type 2', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': True}, {'descriptor_ui': 'D005943', 'descriptor_name': 'Gluconeogenesis', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': True}, {'descriptor_ui': 'D050261', 'descriptor_name': 'Glycogenolysis', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': True}, {'descriptor_ui': 'D007004', 'descriptor_name': 'Hypoglycemic Agents', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D007211', 'descriptor_name': 'Indoles', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D009943', 'descriptor_name': 'Organophosphorus Compounds', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D000409', 'descriptor_name': 'Alanine', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D000409', 'descriptor_name': 'Alanine', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000577', 'descriptor_name': 'Amides', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001786', 'descriptor_name': 'Blood Glucose', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D003924', 'descriptor_name': 'Diabetes Mellitus, Type 2', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004353', 'descriptor_name': 'Drug Evaluation, Preclinical', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005215', 'descriptor_name': 'Fasting', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}, {'descriptor_ui': 'D005215', 'descriptor_name': 'Fasting', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005943', 'descriptor_name': 'Gluconeogenesis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005947', 'descriptor_name': 'Glucose', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D005947', 'descriptor_name': 'Glucose', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D050261', 'descriptor_name': 'Glycogenolysis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007004', 'descriptor_name': 'Hypoglycemic Agents', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007211', 'descriptor_name': 'Indoles', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019344', 'descriptor_name': 'Lactic Acid', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D019344', 'descriptor_name': 'Lactic Acid', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D063065', 'descriptor_name': 'Organophosphonates', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009943', 'descriptor_name': 'Organophosphorus Compounds', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010447', 'descriptor_name': 'Peptide Hydrolases', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D010447', 'descriptor_name': 'Peptide Hydrolases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051381', 'descriptor_name': 'Rats', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1254/jphs.10262fp', 'pdf_url': 'https://www.jstage.jst.go.jp/article/jphs/115/3/115_10262FP/_pdf', 'source': {'id': 'https://openalex.org/S163931769', 'display_name': 'Journal of Pharmacological Sciences', 'issn_l': '1347-8613', 'issn': ['1347-8613', '1347-8648'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/21350313', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1254/jphs.10262fp', 'pdf_url': 'https://www.jstage.jst.go.jp/article/jphs/115/3/115_10262FP/_pdf', 'source': {'id': 'https://openalex.org/S163931769', 'display_name': 'Journal of Pharmacological Sciences', 'issn_l': '1347-8613', 'issn': ['1347-8613', '1347-8648'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/3', 'score': 0.64, 'display_name': 'Good health and well-being'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 24, 'referenced_works': ['https://openalex.org/W1963995578', 'https://openalex.org/W1969550954', 'https://openalex.org/W1986673931', 'https://openalex.org/W1998945191', 'https://openalex.org/W2006921940', 'https://openalex.org/W2018329874', 'https://openalex.org/W2025481353', 'https://openalex.org/W2026339195', 'https://openalex.org/W2028209738', 'https://openalex.org/W2029378794', 'https://openalex.org/W2040535923', 'https://openalex.org/W2059142248', 'https://openalex.org/W2069409707', 'https://openalex.org/W2078795510', 'https://openalex.org/W2083805317', 'https://openalex.org/W2088551222', 'https://openalex.org/W2093827653', 'https://openalex.org/W2098449083', 'https://openalex.org/W2116792548', 'https://openalex.org/W2124148220', 'https://openalex.org/W2128282444', 'https://openalex.org/W2133032019', 'https://openalex.org/W2151380280', 'https://openalex.org/W3217644652'], 'related_works': ['https://openalex.org/W4235769950', 'https://openalex.org/W34308498', 'https://openalex.org/W2409832535', 'https://openalex.org/W2174039389', 'https://openalex.org/W2146698746', 'https://openalex.org/W2084247271', 'https://openalex.org/W2080048202', 'https://openalex.org/W2025095741', 'https://openalex.org/W2020551231', 'https://openalex.org/W187375748'], 'abstract_inverted_index': None, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2064940611', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2018, 'cited_by_count': 1}, {'year': 2017, 'cited_by_count': 1}, {'year': 2015, 'cited_by_count': 1}, {'year': 2014, 'cited_by_count': 1}], 'updated_date': '2024-12-09T15:19:31.532309', 'created_date': '2016-06-24'}