Publication Information

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2724, 2735, 2757, 2792, 2851, 2857, 2929, 2975, 3000, 3037, 3053, 3072, 3096, 3190, 3264, 3291, 3297, 3333, 3379, 3396, 3417, 3534, 3553, 3576, 3641, 3689, 3753, 3766, 3822, 3827, 3914, 3952, 3974, 3979, 4001, 4051, 4057, 4088, 4221, 4291, 4313, 4351], 'survival.': [15, 223], 'The': [16, 116, 224, 324, 416, 2239, 2256, 2263, 2644, 2685, 2698, 2908, 2919, 2937, 2948, 2964, 3080, 3088, 3273, 3287, 3344, 3813, 3836, 3881, 4204, 4227, 4242, 4333, 4357, 4373, 4470], 'microphthalmia': [17, 225], 'transcription': [18, 226, 569, 589, 1467, 1527, 3572], 'factor': [19, 227, 653, 987, 1250, 1468, 2063], '(MITF)': [20, 228, 1469], 'is': [21, 185, 229, 393, 445, 471, 620, 657, 980, 990, 1432, 1470, 1695, 1997, 2089, 3545, 3565, 4076, 4093, 4207, 4245, 4324, 4336, 4376, 4405, 4464], 'required': [22, 230], 'for': [23, 188, 231, 396, 478, 992, 1262, 1764, 1832, 1968, 2091, 2124, 2141, 2372, 2521, 2651, 2902, 2931, 2958, 3005, 3050, 3059, 3124, 3174, 3245, 3261, 3270, 3352, 3384, 3403, 3420, 3462, 3614, 3656, 3724, 3772, 3819, 3959, 4114, 4279, 4407, 4441], 'terminal': [24, 232], 'differentiation': [25, 233, 619, 1264, 1418, 1436, 2093], 'osteoclasts.': [27, 235, 2006, 4203, 4332], 'To': [28, 236], 'determine': [29, 237, 3927], 'whether': [30, 238, 1995], 'MITF': [31, 41, 64, 92, 109, 119, 148, 175, 184, 199, 239, 249, 272, 300, 317, 327, 356, 383, 392, 407, 1586, 1694, 1743, 1761, 1980, 1996, 2010, 2054, 2077, 2178, 2240, 2568, 2679, 2764, 2880, 2921, 3385, 3513, 3533, 3601, 3660, 3806, 3810, 3840, 3847, 3879, 3933, 3990, 4023, 4029, 4040, 4075, 4187, 4193, 4198, 4225, 4446], 'could': [32, 61, 107, 145, 166, 240, 269, 315, 353, 374, 2045, 3992], 'be': [33, 241, 1260, 1982, 2079, 3515, 3993], 'a': [34, 39, 48, 112, 138, 186, 242, 247, 256, 320, 346, 394, 475, 480, 981, 1066, 1405, 1471, 1600, 1747, 1845, 1983, 1998, 2015, 2080, 2084, 2272, 2535, 2716, 2738, 3117, 3217, 3370, 3449, 3516, 3536, 4021, 4043, 4079, 4173, 4208, 4337, 4348], 'target': [35, 87, 123, 187, 243, 295, 331, 395, 1589, 1767, 1984, 2000, 2039, 2082, 3517], 'RANKL': [37, 76, 190, 245, 284, 398, 979, 1075, 1374, 2026, 2135, 2648, 3241, 3818, 3867, 3920, 3965, 3999, 4008, 4200, 4235, 4284, 4329, 4366], 'signaling,': [38, 246], 'phosphospecific': [40, 248, 2879, 2920, 3736, 3846, 4192, 4224, 4354], 'antibody': [42, 250, 2765, 2922, 2950, 3074, 3279, 3610, 3655, 3711, 3737, 3770, 3831, 3848, 3872, 3897, 3923, 4194, 4256, 4387], 'directed': [43, 251], 'against': [44, 252, 2754], 'conserved': [45, 253, 1603, 2016, 2249, 3546, 3567, 4099], 'residue': [46, 254, 3619, 4101], 'Ser307,': [47, 255], 'potential': [49, 257, 1999, 3537], 'mitogen-activated': [50, 258, 1269], 'protein': [51, 259, 567, 587, 1270, 1476, 1748, 1762, 2595, 3720, 3783, 4030], 'kinase': [52, 260, 1271, 3166, 3199, 3234, 3301, 3342], '(MAPK)': [53, 261, 1272], 'site,': [54, 262], 'was': [55, 65, 263, 273, 2011, 2128, 2136, 2146, 2155, 2180, 2245, 2259, 2576, 2582, 2621, 2649, 2680, 2694, 2700, 2711, 2722, 2733, 2744, 2846, 2875, 2884, 2910, 2923, 2939, 2951, 2966, 2995, 3078, 3109, 3602, 3612, 3621, 3639, 3665, 3681, 3707, 3731, 3764, 3842, 3858, 3924, 3966, 4018, 4270, 4433], 'produced.': [56, 264], 'Using': [57, 265, 3986], 'this': [58, 266, 492, 1991, 2731, 2747, 3627, 3963, 4085, 4120], 'antibody,': [59, 267, 2881, 3796, 3989, 4024], 'we': [60, 268, 1977, 1993, 3776], 'demonstrate': [62, 270], 'rapidly': [66, 274], 'persistently': [68, 276, 2012], 'phosphorylated': [69, 277, 2013, 2870, 3603, 3616, 3859, 4106, 4197, 4325], 'upon': [70, 278], 'stimulation': [71, 279, 2163, 3868, 3939, 4000, 4201, 4236, 4330, 4367], 'primary': [73, 281, 2020, 3935], 'osteoclasts': [74, 127, 194, 282, 335, 402, 1001, 1078, 1367, 1698, 2660, 3454, 4108, 4215], 'with': [75, 83, 98, 147, 283, 291, 306, 355, 1357, 2035, 2164, 2253, 2489, 2496, 2596, 2661, 2750, 2848, 3113, 3240, 3277, 3300, 3326, 3667, 3685, 3703, 3755, 3768, 3817, 3829, 3866, 3876, 3895, 4020, 4045, 4254, 4283, 4385, 4409, 4435], 'phosphorylation': [79, 93, 117, 197, 287, 301, 325, 405, 2030, 2052, 2241, 2655, 3539, 3837, 3929, 3991, 4097, 4185], 'Ser307': [81, 95, 110, 289, 303, 318, 3841, 3857, 4404], 'correlated': [82, 97, 290, 305, 2034], 'expression': [84, 125, 292, 333, 2036, 2327, 2370, 2411, 2522, 4312, 4439], 'the': [86, 151, 168, 177, 189, 294, 359, 376, 385, 397, 457, 460, 463, 466, 469, 485, 546, 629, 984, 1071, 1345, 1358, 1362, 1402, 1409, 1417, 1427, 1526, 1608, 1701, 1742, 1756, 1760, 1833, 1956, 1959, 1962, 1973, 1986, 2002, 2038, 2059, 2062, 2066, 2105, 2116, 2142, 2149, 2158, 2173, 2177, 2275, 2288, 2292, 2493, 2498, 2594, 2688, 2720, 2852, 2864, 2872, 2878, 2882, 2998, 3001, 3070, 3073, 3128, 3206, 3359, 3392, 3404, 3407, 3411, 3421, 3453, 3459, 3463, 3510, 3519, 3528, 3558, 3569, 3615, 3629, 3651, 3654, 3678, 3704, 3710, 3735, 3740, 3759, 3773, 3781, 3794, 3830, 3833, 3845, 3871, 3877, 3888, 3891, 3900, 3909, 3928, 3955, 3969, 3987, 4015, 4063, 4090, 4115, 4176, 4232, 4238, 4246, 4250, 4280, 4300, 4305, 4318, 4360, 4363, 4369, 4377, 4381, 4448], 'gene': [88, 124, 144, 155, 206, 296, 332, 352, 363, 414], 'tartrate-resistant': [89, 152, 297, 360, 552], 'acid': [90, 153, 298, 361, 553, 561, 581, 2603, 2692, 3530, 3562, 3728], 'phosphatase.': [91, 299], 'at': [94, 302, 1700, 2055, 2138, 2148, 2601, 2690, 2759, 2905, 2934, 2961, 3047, 3056, 3085, 3116, 3121, 3171, 3242, 3258, 3267, 3284, 3349, 3541, 3560, 3604, 3618, 3726, 4188], 'also': [96, 304, 4072, 4105], 'persistent': [99, 307], 'activation': [100, 121, 308, 329, 3103, 3405], 'p38': [102, 105, 131, 162, 310, 313, 339, 370, 1346, 1428, 1969, 1987, 2003, 2043, 2373, 2528, 2654, 2790, 2835, 3106, 3408, 3520, 3538, 3687, 3705, 3746, 4322, 4355, 4393], 'MAPK,': [103, 311], 'MAPK': [106, 132, 314, 340, 1410, 1429, 1970, 1988, 2004, 2044, 2836, 3226, 3409, 3521, 4323], 'utilize': [108, 316], 'as': [111, 319, 998, 1000, 3132, 4042, 4078, 4123, 4285, 4304, 4466], 'substrate': [113, 321], 'in': [114, 126, 176, 193, 204, 322, 334, 384, 401, 412, 422, 425, 494, 497, 1069, 1349, 1371, 1434, 1607, 1697, 1755, 1989, 2005, 2019, 2023, 2049, 2070, 2115, 2642, 2886, 2914, 2943, 2953, 2970, 2983, 3011, 3045, 3094, 3127, 3195, 3230, 3251, 3256, 3295, 3338, 3391, 3607, 3661, 3683, 3738, 3761, 3784, 3890, 3917, 3934, 3954, 4033, 4054, 4069, 4081, 4107, 4109, 4119, 4172, 4249, 4287, 4299, 4326, 4331, 4380, 4419, 4423, 4477], 'vitro.': [115, 323], 'were': [128, 336, 2102, 2113, 2269, 2296, 2413, 2487, 2508, 2517, 2532, 2606, 2795, 2837, 2981, 3003, 3009, 3043, 3067, 3082, 3090, 3168, 3203, 3214, 3222, 3228, 3238, 3249, 3254, 3275, 3289, 3324, 3346, 3356, 3367, 3375, 3777, 3811, 3815, 3825, 3946, 3977, 4240, 4295, 4371], 'blocked': [129, 337, 1967, 2885, 3402], 'by': [130, 338, 447, 622, 628, 655, 1355, 1597, 2247, 2261, 2534, 2587, 2629, 2635, 2696, 3111, 3205, 3224, 3358, 3377, 3410, 3709, 3734, 3940, 3981, 4062], 'inhibitor': [133, 341, 1407, 3413], 'SB203580.': [134, 342], 'In': [135, 343, 1400, 1689, 3164], 'transient': [136, 178, 344, 386, 2071, 4420], 'transfections,': [137, 345], 'constitutively': [139, 347], 'active': [140, 348], 'Rac1': [141, 349, 4410, 4456], 'or': [142, 350, 1074, 2266, 2503, 2599, 2869, 3742, 3807, 3863, 4411, 4452, 4458, 4461], 'MKK6': [143, 351], 'collaborate': [146, 354], 'to': [149, 201, 357, 409, 549, 1253, 1259, 1373, 1525, 1599, 1766, 1840, 2025, 2064, 2130, 2157, 2570, 2584, 2615, 2632, 2674, 2702, 2718, 2730, 2925, 2997, 3069, 3452, 3508, 3598, 3633, 3643, 3671, 3779, 3903, 3926, 3968, 4095, 4111, 4169, 4309, 4317, 4328], 'activate': [150, 358, 1254], 'phosphatase': [154, 362, 554], 'promoter': [156, 364, 1609, 2068, 2286, 2290], 'dependent': [157, 365], 'on': [158, 366, 1416, 1955, 2014, 3098, 3216, 3369, 4217, 4347], 'Ser307.': [159, 367], 'Dominant': [160, 368], 'negative': [161, 369, 2369], 'α': [163, 371, 3688], 'β': [165, 373], 'inhibit': [167, 375], 'collaboration': [169, 377, 4408], 'between': [170, 378], 'upstream': [171, 379], 'components': [173, 381], 'assays.': [179, 387, 2073], 'These': [180, 388, 1423, 3693], 'results': [181, 389, 496, 1424, 4171], 'indicate': [182, 390, 1425, 4231, 4362], 'pathway': [192, 400, 1348, 1431, 2087, 3522], 'leads': [200, 408], 'an': [202, 410, 419, 3099, 3231, 3609, 3769, 3896, 4218, 4255, 4386], 'increase': [203, 411], 'osteoclast-specific': [205, 413], 'expression.': [207, 415], 'plays': [418], 'important': [420, 991, 1261], 'role': [421], 'bone': [423, 449, 482, 600, 1350, 1420, 1438, 1860, 1963, 2106, 3970, 4275], 'resorption': [424, 444], 'vertebrates': [426], 'during': [427, 3523], 'development': [428], 'throughout': [430, 484], 'life': [431], '(1.Teitelbaum': [432], 'S.L.': [433], 'Science.': [434], '2000;': [435, 972, 1387, 1453, 1634, 1730, 1881, 2319, 2474, 3436], '289:': [436], '1504-1508Crossref': [437], 'PubMed': [438, 537, 613, 646, 827, 868, 1059, 1140, 1181, 1304, 1332, 1395, 1461, 1498, 1520, 1544, 1559, 1581, 1637, 1684, 1733, 1790, 1820, 1884, 1911, 1924, 1949, 2203, 2234, 2322, 2363, 2404, 2440, 2477, 2563, 2827, 3159, 3444, 3474, 3500, 3592, 4155], 'Scopus': [439, 538, 614, 647, 705, 828, 869, 929, 975, 1060, 1141, 1182, 1242, 1305, 1333, 1396, 1462, 1499, 1545, 1560, 1582, 1638, 1685, 1734, 1791, 1821, 1885, 1912, 1925, 1950, 2204, 2235, 2323, 2364, 2405, 2441, 2478, 2564, 2828, 3160, 3445, 3475, 3501, 3593, 4156], '(3007)': [440], 'Google': [441, 540, 616, 649, 707, 830, 871, 931, 977, 1062, 1143, 1184, 1244, 1307, 1335, 1398, 1464, 1501, 1521, 1547, 1562, 1584, 1640, 1660, 1687, 1736, 1793, 1823, 1887, 1914, 1927, 1952, 2206, 2237, 2325, 2366, 2407, 2443, 2480, 2566, 2788, 2830, 3162, 3447, 3477, 3503, 3595, 4158], 'Scholar).': [442, 617, 650, 978, 1063, 1336, 1399, 1585, 1688, 1737, 1824, 1953, 2238, 2567, 2789, 2831, 3163, 3504, 4159], 'This': [443, 453, 3505, 3853], 'counterbalanced': [446], 'new': [448], 'formation': [450, 1363, 2657], 'from': [451, 543, 1829, 2104, 2746, 2839, 3076, 3458, 3948, 4084, 4214, 4274, 4344], 'osteoblasts.': [452], 'process': [454, 476, 493], 'coupling': [456], 'actions': [458], 'bone-producing': [461], 'cells,': [462, 468, 1843, 1976, 2999], 'osteoblasts,': [464], 'bone-resorbing': [467], 'osteoclasts,': [470, 3608, 4345], 'termed': [472, 2243], '"bone': [473], 'remodeling,"': [474], 'necessary': [477, 2090, 4406], 'maintaining': [479], 'constant': [481], 'mass': [483], 'lifetime': [486], 'vertebrate': [488], 'organisms.': [489], 'Disruption': [490], 'humans': [495], 'diseases': [498], 'bone,': [500], 'including': [501, 1267, 3550], 'osteoporosis': [502], 'hypercalcemia': [504], 'malignancy': [506], '(2.Raisz': [507], 'L.G.': [508, 523, 1937, 3488], 'Disorders': [509], 'Bone': [511, 1631, 1727, 1878, 1939, 2316, 2471, 3490, 3942], 'Mineral': [513], 'Metabolism.': [514], 'Raven': [515], 'Press,': [516], 'New': [517, 2340, 2382, 2541, 2705, 2804, 2840, 3137], 'York1992:': [518], '287-311Google': [519], 'Scholar,3.Mundy': [520], 'G.R.': [521], 'Raisz': [522, 1936, 3487], 'Cooper': [524], 'R.A.': [525], 'Schecter': [526], 'G.P.': [527], 'Salmon': [528], 'S.E.': [529], 'N.': [530, 795, 936, 938, 962, 1027, 1108, 1285, 1623, 1719, 1870, 2308, 2463], 'Engl.': [531], 'J.': [532, 679, 699, 756, 793, 813, 815, 874, 900, 906, 1025, 1045, 1047, 1106, 1126, 1128, 1187, 1213, 1219, 1287, 1321, 1384, 1450, 1511, 1630, 1654, 1726, 1804, 1877, 2315, 2343, 2351, 2352, 2397, 2418, 2429, 2470, 2556, 2782, 2807, 2815, 2816, 3152, 3433], 'Med.': [533], '1974;': [534], '291:': [535], '1041-1046Crossref': [536], '(510)': [539], 'Scholar).Osteoclasts': [541], 'differentiate': [542], 'cells': [544, 596, 633, 1354, 1441, 1827, 1966, 2022, 2159, 2449, 2486, 2507, 2980, 3002, 3237, 3814], 'monocyte/macrophage': [547], 'lineage': [548], 'become': [550], 'multinuclear,': [551, 1365], '(TRAP)': [555], '1The': [556, 576], 'abbreviations': [557, 577], 'used': [558, 578, 2147, 2181, 2701, 3642, 3925], 'are:': [559, 579], 'TRAPtartrate-resistant': [560, 580], 'phosphataseRANKreceptor': [562, 582], 'NF-κBRANKLRANK': [565, 585], 'ligandMAPKmitogen-activated': [566, 586], 'kinaseMITFmicrophthalmia': [568, 588], 'factorCSFcolony-stimulating': [570, 590], 'factorHAhemagglutininRIPAradioimmune': [571, 591], 'precipitation': [572, 592], 'assayMops4-morpholinepropanesulfonic': [573, 593], 'acidGSTglutathione': [574, 594], 'S-transferaseOCLosteoclast': [575], 'S-transferaseOCLosteoclast-positive': [595], 'capable': [597], 'resorbing': [599], '(4.Roodman': [601, 634], 'G.D.': [602, 635], 'Exp.': [603, 636], 'Hematol.': [604, 637], '1999;': [605, 638, 865, 926, 1178, 1239, 1296, 2401, 2560, 3156, 3589], '27:': [606, 639], '1229-1241Abstract': [607, 640], 'Full': [608, 610, 641, 643, 822, 824, 1054, 1056, 1135, 1137, 1299, 1301, 1327, 1329, 1390, 1392, 1456, 1458, 1495, 1517, 1787, 1946, 2200, 2358, 2360, 2435, 2437, 2822, 2824, 3439, 3441, 3497, 4150, 4152], 'Text': [609, 611, 642, 644, 823, 825, 1055, 1057, 1136, 1138, 1300, 1302, 1328, 1330, 1391, 1393, 1457, 1459, 1496, 1518, 1788, 1947, 2201, 2359, 2361, 2436, 2438, 2823, 2825, 3440, 3442, 3498, 4151, 4153], 'PDF': [612, 645, 826, 1058, 1139, 1303, 1331, 1394, 1460, 1497, 1519, 1789, 1948, 2202, 2362, 2439, 2826, 3443, 3499, 4154], '(455)': [615, 648], 'Osteoclast': [618], 'influenced': [621], 'hormones': [623], 'local': [625, 652], 'factors': [626, 1252, 1528], 'produced': [627, 2607], 'osteoblasts': [630, 656], 'stromal': [632], 'One': [651], 'expressed': [654, 1369, 1696, 3803, 4303, 4465], 'receptor': [658, 1073], '(5.Dougall': [664], 'W.C.': [665], 'Glaccum': [666], 'M.': [667, 728, 751, 942, 950, 1289, 1316, 1377, 1383, 1443, 1449, 2339, 2381, 2540, 2803, 3136, 3426, 3432, 3579], 'Charrier': [668], 'K.': [669, 671, 673, 904, 940, 948, 958, 1217, 1619, 1645, 1715, 1866, 2304, 2459, 2773], 'Rohrbach': [670], 'Brasel': [672], 'DeSmedt': [674], 'T.': [675, 781, 956, 964, 1013, 1094, 1379, 1445, 1538, 3428], 'Daro': [676], 'E.': [677, 773, 797, 841, 954, 1005, 1029, 1086, 1110, 1154, 1484, 1776, 1798, 2189, 2208], 'Smith': [678], 'Tometsko': [680], 'M.E.': [681, 1929, 3480], 'Maliszewski': [682], 'C.R.': [683, 779, 855, 914, 1011, 1092, 1168, 1227], 'Armstrong': [684], 'A.': [685, 785, 801, 853, 925, 946, 952, 971, 1017, 1033, 1098, 1114, 1166, 1238, 1482, 1615, 1649, 1680, 1711, 1774, 1862, 1907, 2187, 2300, 2455, 2777, 4288], 'Shen': [686], 'V.': [687, 809, 1041, 1122], 'Bain': [688], 'S.': [689, 763, 789, 805, 845, 880, 886, 890, 894, 924, 970, 1021, 1037, 1102, 1118, 1158, 1193, 1199, 1203, 1207, 1237, 1679, 1906], 'Cosman': [690], 'D.': [691, 693, 712, 1283], 'Anderson': [692, 1509], 'Morrissey': [694], 'P.J.': [695], 'Peschon': [696], 'J.J.': [697], 'Schuh': [698], 'Genes': [700, 1539, 1815], 'Dev.': [701, 1540, 1816], '1998;': [702, 819, 1051, 1132, 1324], '13:': [703, 1579], '2412-2424Crossref': [704], '(1188)': [706], 'Scholar,': [708, 769, 831, 872, 932, 1144, 1185, 1308, 1502, 1548, 1563, 1641, 1661, 1794, 1888, 1915, 3478], '6.Hsu,': [709], 'H.,': [710], 'Lacey,': [711], 'L.,': [713, 733, 739], 'Dunstan,': [714], 'C.': [715, 799, 843, 882, 1031, 1112, 1156, 1195], 'R.,': [716, 737], 'Solovyev,': [717], 'I.,': [718, 731], 'Colombero,': [719], 'A.,': [720], 'Timms,': [721], 'E.,': [722], 'Tan,': [723], 'H.-L,': [724], 'Elliot,': [725, 736], 'G.,': [726, 749], 'Kelley,': [727], 'J.,': [729], 'Sarosi,': [730], 'Wang,': [732], 'Xia,': [734], 'X.-Z.,': [735], 'Chiu,': [738], 'Black,': [740], 'T.,': [741], 'Scully,': [742], 'S.,': [743, 747], 'Caparelli,': [744], 'C.,': [745], 'Morony,': [746], 'Shimamoto,': [748], 'Bass,': [750], 'B.,': [752], 'Boyle,': [754], 'W.': [755, 851, 1164], '@@[email': [757], 'protected]@Proc.': [758], 'Natl.': [759, 920, 966, 1233, 1675, 1902], 'Acad.': [760, 921, 967, 1234, 1676, 1903], 'Sci.': [761, 922, 968, 1235, 1677, 1904], 'U.': [762, 923, 969, 1236, 1678, 1905], '[email': [764], 'protected]@/[email': [765], 'protected]@,': [766], '96,': [767], '3540–3545Google': [768], '7.Lacey': [770], 'D.L.': [771, 916, 1003, 1084, 1229], 'Timms': [772, 840, 1004, 1085, 1153], 'Tan': [774, 838, 883, 1006, 1087, 1151, 1196], 'H.-L': [775, 1007, 1088], 'Kelley': [776, 1008, 1089], 'M.J.': [777, 1009, 1090, 1504, 1802], 'Dunstan': [778, 854, 913, 1010, 1091, 1167, 1226], 'Burgess': [780, 1012, 1093], 'Elliot': [782, 786, 887, 1014, 1018, 1095, 1099, 1200], 'R.': [783, 888, 1015, 1096, 1201, 1312], 'Colombero': [784, 1016, 1097], 'G.': [787, 811, 892, 1019, 1043, 1100, 1124, 1205, 1617, 1647, 1663, 1713, 1800, 1864, 1890, 1933, 2302, 2457, 2775, 3484, 4128], 'Scully': [788, 889, 1020, 1101, 1202], 'Hsu': [790, 909, 1022, 1103, 1222], 'H.': [791, 835, 910, 934, 1023, 1104, 1148, 1223, 1291, 1381, 1447, 1490, 1534, 1782, 1808, 2195, 2224, 2337, 2389, 2548, 2801, 3144, 3430], 'Sullivan': [792, 1024, 1105], 'Hawkins': [794, 1026, 1107], 'Davy': [796, 1028, 1109], 'Capparelli': [798, 842, 881, 1030, 1111, 1155, 1194], 'Eli': [800, 1032, 1113], 'Qian': [802, 1034, 1115], 'Y.-X.': [803, 1035, 1116], 'Kaufman': [804, 893, 1036, 1117, 1206], 'Sarosi': [806, 836, 875, 1038, 1119, 1149, 1188], 'I.': [807, 837, 876, 1039, 1120, 1150, 1189], 'Shalhoub': [808, 1040, 1121], 'Senaldi': [810, 1042, 1123], 'Guo': [812, 1044, 1125], 'Delaney': [814, 1046, 1127], 'Boyle': [816, 860, 917, 1048, 1129, 1173, 1230], 'W.J': [817, 1049, 1130], 'Cell.': [818, 1050, 1131, 1295, 1491, 1554, 1576, 1783, 2196, 2399, 2558, 3154, 4146], '93:': [820, 1052, 1133], '165-176Abstract': [821, 1053, 1134], '(4582)': [829, 1061, 1142], '8.Kong': [832, 1145], 'Y.Y.': [833, 1146], 'Yoshida': [834, 1147], 'H.-L.': [839, 884, 1152, 1197], 'Morony': [844, 879, 1157, 1192], 'Oliveira': [846, 1159], 'S.A.': [847, 1160], 'Van': [848, 891, 1161, 1204], 'G.I.': [849, 1162], 'Khoo': [850, 1163], 'Wakeham': [852, 1165], 'Lacey': [856, 915, 1169, 1228], 'D.L': [857, 1170], 'Mak': [858, 1171], 'T.W.': [859, 1172], 'W.J.': [861, 918, 1174, 1231], 'Penninger': [862, 1175], 'J.M.': [863, 1176, 1508], 'Nature.': [864, 1177], '397:': [866, 1179], '315-323Crossref': [867, 1180], '(2834)': [870, 1183], '9.Li': [873, 1186], 'Yan': [877, 1190], 'X-Q.': [878, 1191], 'McCabe': [885, 905, 1198, 1218], 'Juan': [895, 1208], 'S.-C.': [896, 1209], 'Sun': [897, 1210], 'Y.': [898, 1211, 1293, 1320, 2335, 2387, 2422, 2546, 2799, 3142, 4136], 'Tarpley': [899, 1212], 'Martin': [901, 1214], 'L.': [902, 1215, 2341, 2345, 2383, 2426, 2542, 2805, 2809, 3138], 'Christensen': [903, 1216], 'Kostenuik': [907, 1220], 'P.': [908, 1221], 'Fletcher': [911, 1224], 'F.': [912, 1225], 'Proc.': [919, 965, 1232, 1674, 1901], '97:': [927, 1240], '1566-1571Crossref': [928, 1241], '(936)': [930, 1243], '10.Yasuda': [933], 'Shima': [935], 'Nakagawa': [937], 'Yamaguchi': [939], 'Kinosaki': [941], 'Mochizuki': [943], 'S.-I.': [944], 'Tomoyasu': [945], 'Yano': [947], 'Goto': [949], 'Murakami': [951], 'Tsuda': [953], 'Morinaga': [955], 'Higashio': [957], 'Udagawa': [959], 'N': [960], 'Takahashi': [961], 'Suda': [963], '95:': [973], '3597-3602Crossref': [974], '(3526)': [976], 'member': [982], 'tumor': [985, 1248], 'necrosis': [986, 1249], 'superfamily': [988], 'maturation': [993], 'T-': [995], 'B-cells': [997], 'well': [999, 4124], '(7.Lacey': [1002, 1083], 'Mice': [1064], 'containing': [1065, 2291, 3721, 4447], 'targeted': [1067], 'deletion': [1068], 'either': [1070, 2497, 2597, 3739, 3804, 4442], 'RANK': [1072, 3397], 'lack': [1076, 1844], 'differentiated': [1077], 'develop': [1080], 'severe': [1081], 'osteopetrosis': [1082], 'Scholar).RANKL/RANK': [1245], 'signal': [1246], 'through': [1247], 'receptor-associated': [1251], 'multiple': [1255], 'thought': [1258], 'NF-κB,': [1268], 'pathways,': [1273], 'Src': [1274], 'kinase,': [1275, 3182], 'phosphatidylinositol': [1277], '3-kinase': [1278], '(11.Wong': [1280], 'B.R.': [1281, 1310], 'Besser': [1282], 'Kim': [1284], 'Arron': [1286], 'Vologodskaia': [1288], 'Hanafusa': [1290], 'Choi': [1292, 1319], 'Mol.': [1294, 1553, 1575, 2398, 2557, 3153, 4145], '4:': [1297, 1542], '1041-1049Abstract': [1298], '(514)': [1306], '12.Wong': [1309], 'Josien': [1311], 'Lee': [1313, 2419], 'S.Y.': [1314], 'Yologodskaia': [1315], 'Steinman': [1317], 'R.M.': [1318], 'Biol.': [1322, 1385, 1451, 1512, 1555, 1577, 1656, 2353, 2400, 2430, 2559, 2784, 2817, 3155, 3434], 'Chem.': [1323, 1386, 1452, 1513, 2354, 2431, 2818, 3435], '273:': [1325], '28355-28359Abstract': [1326], '(405)': [1334], 'Recently,': [1337], 'it': [1338], 'has': [1339, 2766, 4071], 'been': [1340, 2451, 2767, 3401, 3701], 'shown': [1341, 4161], 'inhibition': [1343], 'marrow-derived': [1351, 1439, 1964, 3943], 'precursor': [1353, 1440, 1826, 1965], 'treatment': [1356, 1375, 4009], 'drug': [1359, 1403], 'SB203580': [1360, 3414], 'inhibited': [1361], 'functional': [1366], 'TRAP': [1370, 1852, 2067, 2285, 2289, 3424, 4290, 4308, 4427], 'response': [1372, 2024, 4110, 4327], '(13.Matsumoto': [1376, 1442, 3425], 'Sudo': [1378, 1444, 3427], 'Osada': [1380, 1446, 3429], 'Tsujimoto': [1382, 1448, 3431], '275:': [1388, 1454, 3437], '31155-31161Abstract': [1389, 1455, 3438], '(470)': [1397, 1463, 3446], 'contrast,': [1401], 'PD98059,': [1404], 'specific': [1406, 3412, 3613, 3771], 'p42/44': [1411], 'pathway,': [1412], 'had': [1413, 3700], 'no': [1414], 'effect': [1415], 'marrow': [1421, 2107, 3971, 4276], 'cells.': [1422, 4426], 'involved': [1433], 'RANKL-induced': [1435], 'Scholar).The': [1465], 'microphthalmia-associated': [1466], 'basic': [1472, 1757], 'helix-loop-helix': [1473], 'leucine': [1474], 'zipper': [1475], '(14.Hodgkinson': [1477, 1769, 2182], 'C.A.': [1478, 1770, 1806, 2183, 2222], 'Moore': [1479, 1771, 2184, 2209], 'K.J.': [1480, 1772, 2185, 2210], 'Nakayama': [1481, 1773, 2186], 'Steingrimsson': [1483, 1775, 1797, 2188], 'Copeland': [1485, 1777, 1809, 2190, 2225], 'N.G.': [1486, 1778, 1810, 2191, 2226], 'Jenkins': [1487, 1779, 1811, 2192, 2227], 'N.A.': [1488, 1780, 1812, 2193, 2228], 'Arnheiter': [1489, 1781, 1807, 2194, 2223], '1993;': [1492, 1514, 1578, 1784, 2197], '74:': [1493, 1785, 2198], '395-404Abstract': [1494, 1786, 2199], '(940)': [1500, 1792, 2205], '15.Hughes': [1503], 'Lingrel': [1505], 'J.B.': [1506], 'Krakowsky': [1507], 'K.P.': [1510], '268:': [1515], '20687-20690Abstract': [1516], 'Scholar)': [1522], 'closely': [1523], 'related': [1524, 3571], 'TFE3,': [1529, 3575], 'TFEB,': [1530], 'TFEC': [1532], '(16.Beckman': [1533], 'Su': [1535], 'L.K.': [1536], 'Kadesch': [1537], '1990;': [1541, 1556], '167-179Crossref': [1543], '(352)': [1546], '17.Carr': [1549], 'C.S.': [1550], 'Sharp': [1551], 'P.A.': [1552], '10:': [1557], '4384-4388Crossref': [1558], '(189)': [1561], '18.Zhao': [1564], 'G.-Q.': [1565], 'Zhao': [1566, 2338, 2802], 'Q.': [1567], 'Zhou': [1568], 'X.': [1569], 'Mattei': [1570], 'M.-G.': [1571], 'De': [1572], 'Crombrugghe': [1573], 'B.': [1574], '4505-4512Crossref': [1580], '(106)': [1583], 'regulates': [1587], 'genes': [1590, 1613, 1768], 'like': [1591], 'TRAP,': [1592], 'cathepsin': [1593, 1854], 'K,': [1594, 1855], 'E-cadherin': [1596], 'binding': [1598, 1765], '7-base': [1601], 'pair': [1602], 'sequence': [1604, 3531], 'TCANGTG': [1605], 'found': [1606], 'regions': [1610], 'these': [1612, 3676, 4055], '(19.Luchin': [1614, 1710, 1861, 2299, 2454], 'Purdom': [1616, 1646, 1712, 1863, 2301, 2456, 2774], 'Murphy': [1618, 1714, 1865, 2303, 2458], 'Clark': [1620, 1716, 1867, 2305, 2460], 'M.-Y.': [1621, 1717, 1868, 2306, 2461], 'Angel': [1622, 1718, 1869, 2307, 2462], 'Cassady': [1624, 1720, 1871, 2309, 2464, 3582], 'A.I.': [1625, 1721, 1872, 2310, 2465, 3583], 'Hume': [1626, 1650, 1722, 1873, 2311, 2466, 2778, 3586], 'D.A.': [1627, 1651, 1723, 1874, 2312, 2467, 2779, 3587], 'Ostrowski': [1628, 1652, 1724, 1875, 2313, 2468, 2780, 3584], 'M.C.': [1629, 1653, 1725, 1876, 2314, 2469, 2781, 3585], 'Miner.': [1632, 1728, 1879, 2317, 2472], 'Res.': [1633, 1729, 1880, 1942, 2318, 2473, 3493], '15:': [1635, 1731, 1882, 2320, 2475], '451-460Crossref': [1636, 1732, 1883, 2321, 2476], '(107)': [1639, 1735, 1886, 2324, 2479], '20.Mansky': [1642], 'K.C.': [1643, 2771], 'Marfatia': [1644, 2772], 'Luchin': [1648, 2776], 'Leukocyte': [1655, 2783], '2002;': [1657, 2785], '71:': [1658, 2786], '295-303PubMed': [1659, 2787], '21.Motyckova': [1662, 1889], 'Weilbaecher': [1664, 1891], 'K.N.': [1665, 1892, 4126], 'Horstmann': [1666, 1893], 'M.A.': [1667, 1894], 'Rieman': [1668, 1895], 'D.J.': [1669, 1896], 'Fisher': [1670, 1672, 1813, 1897, 1899, 4143], 'D.Z.': [1671, 1898], 'D.E.': [1673, 1814, 1900, 4144], '2001;': [1681, 1908, 4147], '98:': [1682, 1909], '5798-5803Crossref': [1683, 1910], '(190)': [1686, 1913], 'situhybridization': [1690], 'experiments': [1691, 2170, 3664, 3694, 4475], 'confirmed': [1692, 2695], 'beginning': [1699], 'earliest': [1702], 'stages': [1703], 'endochondral': [1705], 'ossification': [1706], 'long': [1708], 'bones': [1709], 'A': [1738], 'mutant': [1739, 2258], 'allele': [1740], 'gene,': [1744, 2040], 'mi,': [1745], 'encodes': [1746], 'product': [1749], 'lacking': [1750, 2988], 'one': [1751], 'four': [1753, 3786], 'arginines': [1754], 'region': [1758, 3680], 'critical': [1763], '22.Hemesath': [1795], 'T.J.': [1796, 4134], 'McGill': [1799], 'Hansen': [1801], 'Vaught': [1803], 'Hodgkinson': [1805, 2221], '1994;': [1817, 2231], '8:': [1818, 2232, 4148], '2770-2780Crossref': [1819], '(545)': [1822], 'Osteoclast-like': [1825], 'derived': [1828], 'mice': [1830, 3460, 3951], 'homozygous': [1831, 3461], 'mi': [1834, 3464], 'mutation': [1835, 2295, 3465, 4166], 'are': [1836, 3389, 3456, 4031, 4060, 4302, 4479], 'incapable': [1837], 'fusing': [1839], 'form': [1841, 2175, 2265], 'multinuclear': [1842], 'ruffled': [1846], 'border,': [1847], 'express': [1848], 'low': [1849], 'levels': [1850, 4027], 'cannot': [1857], 'efficiently': [1858], 'resorb': [1859], '23.Thesingh': [1916], 'C.W.': [1917, 3467], 'Scherft': [1918, 3468], 'J.P.': [1919, 3469], 'Bone.': [1920, 3470], '1985;': [1921, 3471], '6:': [1922, 3472], '43-52Crossref': [1923, 3473], '(75)': [1926, 3476], 'Scholar,24.Holtrop': [1928], 'Cox': [1930, 3481], 'K.A.': [1931, 3482], 'Elion': [1932, 3483], 'Simmons': [1934, 3485], 'H.A.': [1935, 3486], 'Metab.': [1938, 3489], 'Dis.': [1940, 3491], 'Relat.': [1941, 3492], '1981;': [1943, 3494], '3:': [1944, 3495], '123-129Abstract': [1945, 3496], '(42)': [1951, 3502], 'Based': [1954], 'similarity': [1957], 'phenotype': [1960, 3451], 'activity': [1971, 2069, 4414], 'mi/mi': [1974], 'osteoclasts-like': [1975], 'hypothesized': [1978], 'may': [1981, 2078], 'osteoclasts.In': [1990], 'study,': [1992], 'investigate': [1994, 3599], 'We': [2007, 2074, 3526], 'show': [2008, 3904, 4480], 'serine': [2017, 2032, 2047, 2056, 2250, 2598, 3542, 3559, 3605, 3617, 3725, 4100, 4189], '307': [2018, 2033, 2048, 2057, 2605, 2693, 3543, 3564, 3606, 3620, 3659, 3730], 'osteoclast-like': [2021], 'TRAP.': [2041], 'Further,': [2042], 'phosphorylate': [2046], 'vitro,': [2050], 'increased': [2058], 'ability': [2060], 'stimulate': [2065], 'transfection': [2072, 4421], 'conclude': [2075], 'direct': [2081], 'RANKL/p38': [2085], 'function.EXPERIMENTAL': [2095], 'PROCEDURESCulture': [2096], 'Analysis': [2098], 'OCLsHematopoietic': [2100], 'precursors': [2101, 3937, 3945], 'obtained': [2103, 2838, 3947], 'wild': [2109, 3949, 4443], 'type': [2110, 2284, 3950, 4087, 4444], 'mice.': [2111], 'OCLs': [2112], 'grown': [2114, 3390], 'presence': [2117, 3129, 3393, 3741, 3956], '50': [2119, 3339], 'ng/ml': [2120, 2140, 3244], 'colony-stimulating': [2121], 'factor-1': [2122], '(CSF-1)': [2123], '3': [2125, 3006, 3752, 3960], 'days.': [2126, 3961], 'CSF-1': [2127, 3395, 3958], 'lowered': [2129], '5': [2131, 3183], 'ng/ml,': [2132], 'then': [2134, 3054, 3265, 4314], 'added': [2137, 2924, 2996, 3068, 3967], '100': [2139, 2511, 3243], 'indicated': [2143, 2150, 4073, 4286, 4449], 'times.SB203580': [2144], '(Calbiochem)': [2145], 'concentration,': [2151], '10': [2152, 3028, 3031, 3034, 3312], 'μm,': [2153], 'applied': [2156], '30': [2160, 3350, 3353, 3996], 'min': [2161, 3052, 3126, 3263, 3865, 3997], 'before': [2162], 'RANKL.DNA': [2165], 'Constructs': [2166], 'TransfectionsFor': [2168], 'all': [2169, 2414, 3785, 4034, 4259, 4390], 'presented': [2171], 'here,': [2172], 'melanocyte': [2174], 'cDNA': [2179], 'Scholar,25.Steingrimsson': [2207], 'Lamoreux': [2211], 'M.L.': [2212], "Rerre-D'Amare": [2213], 'A.R.': [2214], 'Burley': [2215], 'S.K.': [2216], 'Zimring': [2217], 'D.C.S.': [2218], 'Skow': [2219], 'L.C.': [2220], 'Nat.': [2229], 'Genet.': [2230], '256-263Crossref': [2233], '(440)': [2236], 'mutant,': [2242, 4451], 'S307A/P308A,': [2244], 'made': [2246], 'replacing': [2248], 'proline': [2252], 'alanine': [2254, 2600, 3722, 4170], 'residues.': [2255], 'point': [2257, 2267, 4416, 4450], 'verified': [2260], 'sequencing.': [2262], 'full-length': [2264], 'mutants': [2268, 4417], 'cloned': [2270, 2577], 'into': [2271, 2578, 2623], 'vector': [2273, 2624, 4440], 'providing': [2274], 'influenza': [2276], 'hemagglutinin': [2277], 'tag': [2278, 3902], '(HA)': [2279], '(Roche': [2280], 'Molecular': [2281], 'Biochemicals).': [2282], 'Wild': [2283], 'E': [2293], 'box': [2294], 'previously': [2297, 2415, 2452, 2536, 2769, 2796, 3133], 'described': [2298, 2416, 2453, 2537, 2768, 2797, 3134], 'Scholar).Bacterial': [2326], 'constructs': [2328], 'His-tagged': [2330], 'MKK6b(E)': [2331], 'p38α': [2333], '(26.Jiang': [2334, 2798], 'Gram': [2336, 2388, 2547, 2800, 3143], 'Gu': [2342, 2806], 'Feng': [2344, 2425, 2808], 'Padova': [2346, 2390, 2549, 2810, 3145], 'F.D.': [2347, 2391, 2550, 2811, 3146], 'Ulevitch': [2348, 2394, 2427, 2553, 2812, 3149], 'R.J.': [2349, 2395, 2428, 2554, 2813, 3150], 'Han': [2350, 2396, 2555, 2814, 3151], '1997;': [2355, 2819], '272:': [2356, 2820], '30122-30128Abstract': [2357, 2821], '(431)': [2365, 2829], 'Scholar),': [2367, 2408, 3448], 'dominant': [2368], 'plasmids': [2371], 'α,': [2374], 'β,': [2375], 'γ,': [2376], 'δ': [2378], 'isoforms': [2379, 2529], '(27.Zhao': [2380, 2539, 3135], 'Kravchenko': [2384, 2543, 3139], 'V.V.': [2385, 2544, 3140], 'Kato': [2386, 2545, 3141], 'Olson': [2392, 2551, 3147], 'E.N.': [2393, 2552, 3148], '19:': [2402, 2561, 3157], '21-30Crossref': [2403, 2562, 3158], '(376)': [2406, 2565, 3161], 'MKK6(E)': [2410, 2531, 3115, 4459], 'plasmid': [2412, 2499], '(28.Han': [2417], 'J.-D.': [2420], 'Jiang': [2421], 'Li': [2423], 'Z.': [2424], '1996;': [2432], '271:': [2433], '2886-2891Abstract': [2434], '(482)': [2442], 'Scholar).DNA': [2444], 'transfections': [2445], 'RAW': [2447, 3797, 4424], '264': [2448], 'have': [2450, 3400], 'Scholar).Construction': [2481], 'Cell': [2483, 2843], 'LinesRAW': [2484], '264.7': [2485, 3798, 4425], 'transfected': [2488], 'Superfect': [2490], '(Qiagen)': [2491, 2637], 'following': [2492, 3860, 3995, 4003], "manufacturer's": [2494, 2873], 'directions': [2495], 'expressing': [2500], 'HA-tagged': [2501, 2504, 3805, 3809], 'S73AMITF': [2502], 'S73A/S307A/P308AMITF,': [2505], 'selected': [2509], 'using': [2510, 2863, 3177, 3844, 4223, 4272, 4353], 'μg/ml': [2512, 3029, 3032, 3035], 'Geneticin': [2513], '(Invitrogen).': [2514], 'Individual': [2515], 'clones': [2516], 'picked': [2518], 'screened': [2520], 'HA-MITF.Preparation': [2524], 'Recombinant': [2526, 3719], 'ProteinsRecombinant': [2527], 'prepared': [2533, 3826, 3978, 4083], 'method': [2538], 'corresponding': [2569, 2614, 2673, 3670], 'amino': [2571, 2602, 2616, 2675, 2691, 3529, 3561, 3634, 3672, 3727], 'acids': [2572, 2617, 2676, 3635, 3673], '297–377': [2573], '(nucleotides': [2574, 2619], '1018–1263)': [2575], 'pGEX2t': [2579], '(Pharmacia)': [2580], 'purified': [2583, 2628], '95%': [2585, 2633], 'purity': [2586, 2634], 'glutathione': [2588], 'Sepharose': [2589], 'affinity': [2590, 2638, 2740, 3649], 'chromatography.': [2591], 'Versions': [2592], 'position': [2604, 2686, 3563, 3729], 'purified.RANKL': [2609], 'Bacterial': [2610], 'Expression': [2611], 'PurificationRANKL': [2613], '158–316': [2618], '472–978)': [2620], 'placed': [2622], 'pET': [2625], '32b': [2626], '(Novagene),': [2627], 'native': [2630], 'lysis': [2631], 'nickel-Sepharose': [2636], 'chromatography': [2639], 'eluted': [2641, 2745], 'imidazole.': [2643], 'concentration': [2645], 'soluble': [2647], 'optimized': [2650], 'induction': [2652], 'TRAP-positive': [2659], 'each': [2662], 'preparation.Immunological': [2663], 'Reagents': [2664], 'AnalysisThe': [2666], 'peptide': [2667, 3630], 'PSTGLSpSPDLVN': [2668, 3631], '(where': [2669], 'pS': [2670], 'represents': [2671, 3887], 'phosphoserine),': [2672], '301–312': [2677, 3636], 'synthesized': [2681, 3640], '(QCB/BIOSOURCE,': [2682], 'Hopkinton,': [2683], 'MA).': [2684], 'phosphate': [2689], 'NMR.': [2697], 'phosphopeptide': [2699, 2739], 'immunize': [2703], 'two': [2704, 3298], 'Zealand': [2706], 'White': [2707], 'rabbits.': [2708], 'Collected': [2709], 'serum': [2710], 'pooled': [2712], 'passed': [2714, 2736], 'over': [2715, 2737], 'column': [2717, 2732, 2749], 'which': [2719], 'nonphosphopeptide': [2721], 'coupled,': [2723], 'material': [2725, 2743], 'did': [2727, 3873], 'not': [2728, 3566, 3732, 3874], 'bind': [2729], 'collected': [2734, 3290], 'column.': [2741], 'Bound': [2742], 'second': [2748], 'glycine': [2751], 'buffer,': [2752], 'dialyzed': [2753], 'phosphate-buffered': [2755], 'saline,': [2756], 'stored': [2758], '−70': [2760], '°C.': [2761, 3087, 3286], 'Polyclonal': [2762], 'phosphorylation-independent': [2763], '(20.Mansky': [2770], 'α-': [2791], 'β-specific': [2793], 'antibodies': [2794, 2865], 'Antibodies': [2832, 3382], 'recognized': [2834, 3708, 3733], 'England': [2841], 'Biolabs': [2842], 'Signaling.Western': [2844], 'blotting': [2845, 3663, 3983], 'performed': [2847, 4271, 4476], 'nitrocellulose': [2849], 'membranes': [2850], 'ECL': [2853], 'detection': [2854], 'system': [2855], '(Kirkegaard': [2856], 'Perry': [2858], 'Laboratories).': [2859], 'For': [2860, 2877, 3626, 3675], 'Western': [2861, 3662, 3982, 4209, 4338], 'blots': [2862], 'recognize': [2867], 'total': [2868], 'p38,': [2871], 'protocol': [2874], 'followed.': [2876], 'blot': [2883, 2909, 2938, 2965, 3760, 3889, 4017, 4210, 4248, 4339, 4379], 'TBS': [2887], '(50': [2888, 3013], 'mm': [2889, 2894, 3014, 3019, 3039, 3304, 3309, 3313, 3318], 'Tris,': [2890], 'pH': [2891, 3016, 3306], '7.5,': [2892, 3307], '150': [2893, 3331], 'NaCl),': [2895], '0.1%': [2896, 2916, 2945, 2955, 2972], 'Tween': [2897, 2917, 2946, 2956, 2973], '20,': [2898], '5%': [2899], 'powdered': [2900], 'milk': [2901], '2': [2903, 2932], 'h': [2904, 2933, 2960, 4005], 'room': [2906, 2935, 2962], 'temperature.': [2907, 2936, 2963], 'washed': [2911, 2940, 2967, 3091, 3292], 'three': [2912, 2941, 2968, 3092, 3293, 4473], 'times': [2913, 2942, 2969, 3093, 3294, 3299], 'TBS,': [2915, 2944, 2954, 2971], '20.': [2918, 2947], 'fresh': [2926], 'blocking': [2927], 'buffer': [2928, 3302], 'incubated': [2930, 2952, 3044, 3083, 3255, 3276, 3348, 3682, 3702], 'secondary': [2949], '20': [2957, 2974, 3051, 3060, 3196, 3262, 3271], '1': [2959, 3038, 3315, 3317, 3715], 'developed.For': [2976], '[35S]methionine': [2977, 2993], 'labeling': [2978], 'experiments,': [2979, 3677, 4056], 'starved': [2982], "Dulbecco's": [2984], 'modified': [2985], "Eagle's": [2986], 'medium': [2987], 'methionine.': [2989], '90': [2990], 'μCi': [2991, 3192, 3335], '(ICN)': [2994], 'labeled': [3004], 'h.': [3007], 'Cells': [3008, 3042, 3248, 3253], 'lysed': [3010, 3250], 'RIPA': [3012, 3046, 3095, 3257, 3296], 'Tris-HCl,': [3015], '7.6,': [3017], '125': [3018], 'NaCl,': [3020], '1%': [3021], 'Nonidet': [3022], 'P-40,': [3023], '0.5%': [3024], 'deoxycholate)': [3025], 'included': [3027], 'antipain,': [3030], 'leupeptin,': [3033], 'aprotinin,': [3036], 'sodium': [3040, 3319], 'vanadate.': [3041], '4': [3048, 3086, 3259, 3285, 3754], '°C': [3049, 3123, 3173, 3260, 3351], 'centrifuged': [3055, 3266], '25,000': [3057, 3268], 'rpm': [3058, 3269], 'min.': [3061, 3247, 3272, 3354], 'Protein': [3062], 'G': [3063], 'beads': [3064], '(Amersham': [3065], 'Biosciences)': [3066], 'lysate,': [3071], '(HA': [3075], 'Babco)': [3077], 'added.': [3079], 'immunoprecipitates': [3081, 3089, 3274, 3288], 'overnight': [3084, 3283], 'run': [3097, 4216, 4346], '8%': [3100, 4219], 'SDS-PAGE.Kinase': [3101], 'AssayFull': [3102], 'recombinant': [3105, 3114, 3181, 3668, 3782], 'αin': [3107], 'vitro': [3108, 3165, 3684], 'achieved': [3110], 'incubation': [3112], '5:1': [3118], 'molar': [3119], 'ratio': [3120, 4306], '37': [3122, 3172], '15': [3125, 3175, 3246], 'ATP': [3131, 3690], 'assays': [3167, 4422], 'carried': [3169], 'out': [3170], 'min,': [3176], '0.2': [3178], 'μg': [3179, 3184, 3328, 4437, 4454], 'GST-MITF,': [3186, 3330], '250': [3187], 'μm': [3188], 'ATP,': [3189], '12': [3191, 3334], '[γ-32P]ATP': [3194, 3337], 'μl': [3197, 3340], 'reaction': [3200], 'buffer.': [3201, 3211, 3343, 3364], 'Reactions': [3202, 3355], 'terminated': [3204, 3357], 'addition': [3207, 3360], 'SDS': [3209, 3362], 'sample': [3210, 3363], 'Reaction': [3212, 3365], 'products': [3213, 3366], 'resolved': [3215, 3368, 4077], '10%': [3218, 3371, 4349], 'SDS-PAGE.': [3219, 3372], 'Phosphorylated': [3220, 3373, 3916], 'proteins': [3221, 3374], 'visualized': [3223, 3376], 'autoradiography.p38': [3225], 'activities': [3227], 'measured': [3229, 4418], 'immune': [3232], 'complex': [3233], 'assay.': [3235], 'RAW264.7': [3236], 'stimulated': [3239, 3816], 'RIPA.': [3252], 'anti-p38': [3278, 3323], '(Cell': [3280], 'Signaling': [3281], 'Technology)': [3282], '(20': [3303], 'Mops,': [3305], '25': [3308], 'β-glycerol': [3310], 'phosphate,': [3311], 'MgCl2,': [3314], 'mmdithiothreitol,': [3316], 'vanadate).': [3320], 'Immunoprecipitates': [3321], 'mixed': [3325], '0.5': [3327, 4436], 'μmATP,': [3332], 'reactions': [3345], 'further': [3347, 3792, 4315], 'autoradiography.RESULTSProduction': [3378], 'Characterization': [3380], 'Specific': [3383], 'Phosphoserine': [3386], '307Osteoclasts': [3387], 'but': [3399, 3869], 'remain': [3415], 'mononuclear': [3416], 'stain': [3418], 'weakly': [3419], 'marker': [3423], 'similar': [3450], 'cultured': [3457, 3953], '(23.Thesingh': [3466], '24.Holtrop': [3479], 'led': [3506], 'us': [3507], 'test': [3509], 'hypothesis': [3511], 'might': [3514], 'differentiation.': [3525], 'analyzed': [3527, 3980], 'discovered': [3535], 'site': [3540], 'among': [3547, 3568], 'different': [3548], 'species': [3549], 'human,': [3551], 'mouse,': [3552], 'chicken': [3554], '(Fig.': [3555, 3691, 3712, 3748, 3788, 3849, 3984, 4010, 4036, 4065], '1A).': [3556], 'However,': [3557], 'other': [3570], 'factors,': [3573], 'TFEC,': [3574], 'TFEB': [3577], '(29.Rehli': [3578], 'Elzen': [3580], 'N.D.': [3581], 'Genomics.': [3588], '56:': [3590], '111-120Crossref': [3591], '(74)': [3594], 'Scholar).To': [3596], 'begin': [3597], 'if': [3600], 'developed': [3622], '(see': [3623, 4163, 4180], '"Experimental': [3624], 'Procedures").': [3625], 'purpose,': [3628], '(corresponding': [3632], 'MITF)': [3638], 'produce': [3644], 'polyclonal': [3645], 'rabbit': [3646], 'serum.': [3647], 'Following': [3648], 'purification,': [3650], 'specificity': [3652], 'detecting': [3657], 'phosphoserine': [3658], 'tested': [3666], 'GST-MITF': [3669, 3679, 3698], '297–377.': [3674], 'activated': [3686, 3745], '1B).': [3692], 'showed': [3695], 'only': [3697], 'preparation': [3706], '1B,': [3713, 3749, 3789], 'lane': [3714, 3717, 3756], 'versus': [3716], '2).': [3718, 3985], 'substituted': [3723], 'absence': [3743], 'MAPK.': [3747], 'compare': [3750], 'lanes': [3751, 3787, 4035, 4230, 4361], '1).': [3757], 'When': [3758, 4014], 'Fig.': [3762, 3885, 4164, 4181], '1B': [3763], 'stripped': [3765], 'reprobed': [3767, 3894, 4019, 4253, 4384], 'GST': [3774], 'moiety,': [3775], 'able': [3778], 'detect': [3780], 'bottom': [3790, 3882, 4243, 4374], 'panel).To': [3791], 'characterize': [3793], 'phospho-Ser307-specific': [3795], 'cell': [3799, 3823, 3972, 4086, 4121, 4342], 'lines': [3800], 'stably': [3802], 'S307A/P308A': [3808, 3878], 'created.': [3812], 'various': [3820], 'times,': [3821], 'extracts': [3824, 3976, 4082, 4213, 4239, 4343, 4370], 'immunoprecipitated': [3828], 'recognizing': [3832], 'HA': [3834, 3901], 'epitope.': [3835], 'status': [3838, 3930], 'determined': [3843], '1C,': [3850], 'top': [3851, 3892, 4205, 4251, 4334, 4382], 'panel).': [3852, 4013, 4039], 'analysis': [3854], 'demonstrated': [3855], '15,': [3861], '30,': [3862], '60': [3864], 'react': [3875], 'protein.': [3880], 'panel': [3883, 3893, 4206, 4244, 4252, 4335, 4375, 4383], '1C': [3886], 'recognizes': [3899, 4196, 4258, 4389], 'approximately': [3905, 4025], 'equal': [3906, 4026], 'loading': [3907], 'HA-containing': [3910], 'immunoprecipitates.MITF': [3911], 'Is': [3912], 'Rapidly': [3913], 'Persistently': [3915], 'Osteoclasts': [3918], 'after': [3919, 3938, 4199, 4234, 4365], 'StimulationThe': [3921], 'anti-phospho-MITF': [3922], 'endogenous': [3932], 'RANKL.': [3941], 'At': [3962], 'time,': [3964], 'cultures,': [3973], 'nuclear': [3975, 4212], 'anti-phospho-Ser307': [3988], 'detected': [3994, 4061], 'persisted': [4002], '24': [4004], 'continuous': [4007], '2A,': [4011, 4037], 'upper': [4012, 4091], 'same': [4016, 4247, 4281, 4378], 'nondiscriminating': [4022], 'seen': [4032], 'lower': [4038], 'appeared': [4041], 'doublet': [4044, 4080, 4116], 'electrophoretic': [4046], 'mobility': [4047], 'around': [4049], '55': [4050], '57': [4052], 'kDa': [4053], 'both': [4058], 'bands': [4059], 'anti-phospho-Ser307antibody': [4064], '2A).': [4066], 'Previous': [4067], 'work': [4068], 'melanocytes': [4070], 'band': [4092, 4117, 4179], 'due': [4094], 'c-Kit-mediated': [4096], '73': [4102], '(30).': [4103], 'Ser73is': [4104], 'CSF-1,': [4112], 'accounting': [4113], 'pattern': [4118], 'line': [4122], '(31.Weilbaecher': [4125], 'Motyckova': [4127], 'Huber': [4129], 'W.E.': [4130], 'Takemoto': [4131], 'C.M.': [4132], 'Hemesath': [4133], 'Xu': [4135], 'Hershey': [4137], 'C.L.': [4138], 'Dowland': [4139], 'N.R.': [4140], 'Wells': [4141], 'A.G.': [4142], '749-758Abstract': [4149], '(132)': [4157], 'As': [4160], 'below': [4162], '5)': [4165], 'Ser73': [4168], 'loss': [4174], 'slower': [4177], 'migrating': [4178], '5).Figure': [4182], '2RANKL': [4183], 'stimulates': [4184], '307.': [4190], 'A,': [4191, 4413], 'SDS-PAGE': [4220, 4350], 'probed': [4222, 4352], 'antibody.': [4226, 4356], 'numbers': [4228, 4358], 'abovethe': [4229], 'hours': [4233, 4364], 'collected.': [4241, 4372], 'forms': [4260, 4391], 'MITF.': [4262], 'B,': [4263], 'real': [4264], 'time': [4265, 4282], 'quantitative': [4266], 'RT-PCR': [4267], '(Taqman': [4268], 'assay)': [4269], 'RNA': [4273, 4294], 'cultures': [4277], 'treated': [4278], 'Both': [4289], 'glyceraldehyde-3-phosphate': [4292, 4310], 'dehydrogenase': [4293, 4311], 'quantitated.': [4296], 'All': [4297], 'values': [4298], 'chart': [4301], 'normalized': [4316], 'CSF-1-only': [4319], 'control.': [4320], 'C,': [4321], 'whole': [4341], 'above': [4359], 'MAPK.View': [4394], 'Large': [4395], 'Image': [4396], 'Figure': [4397], 'ViewerDownload': [4398], 'Hi-res': [4399], 'image': [4400], 'Download': [4401], '(PPT)Figure': [4402], '5MITF': [4403], 'MKK6.': [4412], 'luciferase': [4428, 4468], 'reporter': [4429], 'construct': [4430], '(2.5': [4431], 'μg)': [4432], 'co-transfected': [4434], 'MITF,': [4445], '0.4': [4453], '15L': [4457], 'alone': [4460], 'together.': [4462], 'Activity': [4463], 'relative': [4467], 'activity.': [4469], 'averages': [4471], 'independent': [4474], 'duplicate': [4478]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2064904666', 'counts_by_year': [{'year': 2024, 'cited_by_count': 9}, {'year': 2023, 'cited_by_count': 6}, {'year': 2022, 'cited_by_count': 8}, {'year': 2021, 'cited_by_count': 3}, {'year': 2020, 'cited_by_count': 9}, {'year': 2019, 'cited_by_count': 10}, {'year': 2018, 'cited_by_count': 12}, {'year': 2017, 'cited_by_count': 11}, {'year': 2016, 'cited_by_count': 8}, {'year': 2015, 'cited_by_count': 16}, {'year': 2014, 'cited_by_count': 12}, {'year': 2013, 'cited_by_count': 7}, {'year': 2012, 'cited_by_count': 10}], 'updated_date': '2024-12-17T03:46:46.814236', 'created_date': '2016-06-24'}