Title: Role of chelating agents for prevention, intervention, and treatment of exposures to toxic metals.
Abstract: Research ArticleOpen AccessRole of chelating agents for prevention, intervention, and treatment of exposures to toxic metals.is companion ofChelation of toxic metals: current interests. R A Goyer, M G Cherian, M M Jones, and J R Reigart R A Goyer National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA. , M G Cherian National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA. , M M Jones National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA. , and J R Reigart National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA. Published:1 November 1995https://doi.org/10.1289/ehp.951031048Cited by:42AboutSectionsPDF ToolsDownload CitationsTrack Citations ShareShare onFacebookTwitterLinked InReddit FiguresReferencesRelatedDetailsCited by Nardon C, Brustolin L and Fregona D (2016) Is matching ruthenium with dithiocarbamato ligands a potent chemotherapeutic weapon in oncology?, Future Medicinal Chemistry, 10.4155/fmc.15.175, 8:2, (211-226), Online publication date: 1-Feb-2016. Ansar S (2015) Effect of Selenium on the Levels of Cytokines and Trace Elements in Toxin-Mediated Oxidative Stress in Male Rats, Biological Trace Element Research, 10.1007/s12011-015-0403-7, 169:1, (129-133), Online publication date: 1-Jan-2016. Zhao W, Song B, Tao J, Zhang J, Huang M, Wang C and Gou M (2016) Thiol-Functionalized Mesoporous Silica for Effective Trap of Mercury in Rats, Journal of Nanomaterials, 10.1155/2016/9758264, 2016, (1-10), . Capaldo A, Gay F, Scudiero R, Trinchella F, Caputo I, Lepretti M, Marabotti A, Esposito C and Laforgia V (2016) Histological changes, apoptosis and metallothionein levels in Triturus carnifex (Amphibia, Urodela) exposed to environmental cadmium concentrations, Aquatic Toxicology, 10.1016/j.aquatox.2016.01.009, 173, (63-73), Online publication date: 1-Apr-2016. Peng C, Muthusamy S, Xia Q, Lal V, Denison M and Ng J (2015) Micronucleus formation by single and mixed heavy metals/loids and PAH compounds in HepG2 cells, Mutagenesis, 10.1093/mutage/gev021, 30:5, (593-602), Online publication date: 1-Sep-2015. Sisombath N, Jalilehvand F, Schell A and Wu Q (2014) Lead(II) Binding to the Chelating Agent d -Penicillamine in Aqueous Solution , Inorganic Chemistry, 10.1021/ic5018714, 53:23, (12459-12468), Online publication date: 1-Dec-2014. Han D, Wang H, Yue H and Wang S (2013) Study on the In Vitro Effects of the Mixtures of Polycyclic Aromatic Hydrocarbons (PAHs) and Heavy Metals on Ethoxyresorufin-O-Deethylase (EROD) Activity in Mossambica tilapia Liver, Bulletin of Environmental Contamination and Toxicology, 10.1007/s00128-013-1075-7, 91:4, (460-464), Online publication date: 1-Oct-2013. Quig D (2013) Metal Toxicity Textbook of Natural Medicine, 10.1016/B978-1-4377-2333-5.00023-7, (191-199), . Gay F, Laforgia V, Caputo I, Esposito C, Lepretti M and Capaldo A (2013) Chronic Exposure to Cadmium Disrupts the Adrenal Gland Activity of the Newt Triturus carnifex (Amphibia, Urodela) , BioMed Research International, 10.1155/2013/424358, 2013, (1-6), . Flora S (2013) Chelation Therapy Comprehensive Inorganic Chemistry II, 10.1016/B978-0-08-097774-4.00340-5, (987-1013), . Tomilova I, Gromova O and Grishina O (2012) Macro- and microelements in the brains of fetuses and newborns in normal and pathological states: A review, Neurochemical Journal, 10.1134/S1819712412010084, 6:1, (1-6), Online publication date: 1-Mar-2012. Freeman E, Torvaldsen S, Capon A and Lawrence G (2012) Trends in notifiable blood lead levels in NSW, 1998?2008, New South Wales Public Health Bulletin, 10.1071/NB11033, 23:12, (228), . Saxena R, Pai P and Bell G (2010) Nephrotoxic effects of workplace exposures Hunter's Diseases of Occupations, Tenth Edition, 10.1201/b13467-121, (1125-1150), Online publication date: 29-Oct-2010. Hispard F, de Vaufleury A, Martin H, Devaux S, Cosson R, Scheifler R, Richert L, Berthelot A and Badot P (2008) Effects of subchronic digestive exposure to organic or inorganic cadmium on biomarkers in rat tissues, Ecotoxicology and Environmental Safety, 10.1016/j.ecoenv.2007.04.005, 70:3, (490-498), Online publication date: 1-Jul-2008. Loumbourdis N, Kostaropoulos I, Theodoropoulou B and Kalmanti D (2007) Heavy metal accumulation and metallothionein concentration in the frog Rana ridibunda after exposure to chromium or a mixture of chromium and cadmium, Environmental Pollution, 10.1016/j.envpol.2006.05.011, 145:3, (787-792), Online publication date: 1-Feb-2007. Beaudin S, Stangle D, Smith D, Levitsky D and Strupp B (2007) Succimer chelation normalizes reactivity to reward omission and errors in lead-exposed rats, Neurotoxicology and Teratology, 10.1016/j.ntt.2006.11.004, 29:2, (188-202), Online publication date: 1-Mar-2007. Passos C, Mergler D, Fillion M, Lemire M, Mertens F, Guimarães J and Philibert A (2007) Epidemiologic confirmation that fruit consumption influences mercury exposure in riparian communities in the Brazilian Amazon, Environmental Research, 10.1016/j.envres.2007.01.012, 105:2, (183-193), Online publication date: 1-Oct-2007. Hamidinia S, Erdahl W, Chapman C, Steinbaugh G, Taylor R and Pfeiffer D (2005) Monensin Improves the Effectiveness of meso-Dimercaptosuccinate when Used to Treat Lead Intoxication in Rats, Environmental Health Perspectives, 114:4, (484-493), Online publication date: 1-Apr-2006. Santos F, Zeni G, Rocha J, do Nascimento P, Marques M and Nogueira C (2005) Efficacy of 2,3-dimercapto-1-propanesulfonic acid (DMPS) and diphenyl diselenide on cadmium induced testicular damage in mice, Food and Chemical Toxicology, 10.1016/j.fct.2005.05.015, 43:12, (1723-1730), Online publication date: 1-Dec-2005. Jaffe R (2005) First Line Comprehensive Care. Part II: Anthropogenic Xenobiotics in Functional Medicine. Managing Persisting Bioaccumulating Pollutants: Toxic Minerals, Biocides, Hormone Mimics, Solvents, and Chemical Disruptors, Seminars in Integrative Medicine, 10.1016/j.sigm.2005.11.001, 3:3, (79-92), Online publication date: 1-Sep-2005. Kalia K and Flora S (2005) Strategies for Safe and Effective Therapeutic Measures for Chronic Arsenic and Lead Poisoning, Journal of Occupational Health, 10.1539/joh.47.1, 47:1, (1-21), . Rencová J, Vlková A, Čuřík R, Holuša R and Veselá G (2009) Influence of heavy metals upon the retention and mobilization of polonium‐210 in rats, International Journal of Radiation Biology, 10.1080/09553000400017911, 80:10, (769-776), Online publication date: 1-Oct-2004. Saxena G and Flora S (2004) Lead-induced oxidative stress and hematological alterations and their response to combined administration of calcium disodium EDTA with a thiol chelator in rats, Journal of Biochemical and Molecular Toxicology, 10.1002/jbt.20027, 18:4, (221-233), . Roach R and Busch S (2018) Mercury exposure aboard an ore boat., Environmental Health Perspectives, 112:8, (910-913), Online publication date: 1-Jun-2004. Tandon S, Singh S, Prasad S, Khandekar K, Dwivedi V, Chatterjee M and Mathur N (2003) Reversal of cadmium induced oxidative stress by chelating agent, antioxidant or their combination in rat, Toxicology Letters, 10.1016/S0378-4274(03)00265-0, 145:3, (211-217), Online publication date: 1-Dec-2003. Tandon S, Prasad S and Singh S (2002) Chelation in metal intoxication: influence of cysteine orN-acetyl cysteine on the efficacy of 2,3-dimercaptopropane-1-sulphonate in the treatment of cadmium toxicity, Journal of Applied Toxicology, 10.1002/jat.827, 22:1, (67-71), Online publication date: 1-Jan-2002. Pande M, Mehta A, Pant B and Flora S (2001) Combined administration of a chelating agent and an antioxidant in the prevention and treatment of acute lead intoxication in rats, Environmental Toxicology and Pharmacology, 10.1016/S1382-6689(01)00064-3, 9:4, (173-184), Online publication date: 1-Mar-2001. Cai L, Koropatnick J and Cherian M (2001) Roles of vitamin C in radiation-induced DNA damage in presence and absence of copper, Chemico-Biological Interactions, 10.1016/S0009-2797(01)00210-1, 137:1, (75-88), Online publication date: 1-Jul-2001. Lasky R, Laughlin N and Luck M (2001) The Effects of Elevated Blood Lead Levels and Succimer Chelation Therapy on Physical Growth in Developing Rhesus Monkeys, Environmental Research, 10.1006/enrs.2001.4278, 87:1, (21-30), Online publication date: 1-Sep-2001. Lasky R, Luck M and Laughlin N (2001) The effects of succimer chelation therapy on auditory function in rhesus monkeys, Neurotoxicology and Teratology, 10.1016/S0892-0362(01)00176-3, 23:6, (651-658), Online publication date: 1-Nov-2001. Cremin J, Luck M, Laughlin N and Smith D (2018) Oral succimer decreases the gastrointestinal absorption of lead in juvenile monkeys., Environmental Health Perspectives, 109:6, (613-619), Online publication date: 1-Jun-2001. Smith D, Woolard D, Luck M and Laughlin N (2000) Succimer and the Reduction of Tissue Lead in Juvenile Monkeys, Toxicology and Applied Pharmacology, 10.1006/taap.2000.8973, 166:3, (230-240), Online publication date: 1-Aug-2000. Kostial K, Restek-Samar?ija N, Piasek M, Varnai V, Blanu?a M, Jones M and Singh P (2000) Combined treatment withracemic-DMSA and EDTA for lead mobilization in rats, The Journal of Trace Elements in Experimental Medicine, 10.1002/1520-670X(2000)13:3<277::AID-JTRA5>3.0.CO;2-2, 13:3, (277-284), . Tandon S and Singh S (2000) Role of vitamins in treatment of lead intoxication, The Journal of Trace Elements in Experimental Medicine, 10.1002/1520-670X(2000)13:3<305::AID-JTRA8>3.0.CO;2-F, 13:3, (305-315), . Tandon S and Prasad S (2016) Effect of thiamine on the cadmium–chelating capacity of thiol compounds, Human & Experimental Toxicology, 10.1191/096032700668935303, 19:9, (523-528), Online publication date: 1-Sep-2000. Seaton C, Lasman J and Smith D (1999) The Effects of CaNa2EDTA on Brain Lead Mobilization in Rodents Determined Using a Stable Lead Isotope Tracer, Toxicology and Applied Pharmacology, 10.1006/taap.1999.8725, 159:3, (153-160), Online publication date: 1-Sep-1999. Smith D, Bayer L and Strupp B (1998) Efficacy of Succimer Chelation for Reducing Brain Pb Levels in a Rodent Model, Environmental Research, 10.1006/enrs.1998.3854, 78:2, (168-176), Online publication date: 1-Aug-1998. Rao A, Prasad V and Sood P (2016) Monothiols and Vitamins are Ideal Therapeutic Agents for Mercury Elimination from Nervous and Non-Nervous Tissues of Fish, Nutritional Neuroscience, 10.1080/1028415X.1998.11747248, 1:5, (383-390), Online publication date: 1-Jan-1998. Dieter M (2018) Friendly Fire, Environmental Health Perspectives, 104:7, (682-682), Online publication date: 1-Jul-1996. Jacobs D (2012) Lead Patty's Toxicology, 10.1002/0471435139.tox034.pub2, (381-426) Yadav A and Flora S (2016) Nano drug delivery systems: a new paradigm for treating metal toxicity, Expert Opinion on Drug Delivery, 10.1517/17425247.2016.1160890, (1-11) Goyer R (2001) Lead Patty's Toxicology, 10.1002/0471435139.tox034 Related articlesChelation of toxic metals: current interests.1 November 1995Environmental Health Perspectives Vol. 103, No. 11 November 1995Metrics About Article Metrics Publication History Originally published1 November 1995Published in print1 November 1995 Financial disclosuresPDF download License information EHP is an open-access journal published with support from the National Institute of Environmental Health Sciences, National Institutes of Health. All content is public domain unless otherwise noted. Note to readers with disabilities EHP strives to ensure that all journal content is accessible to all readers. However, some figures and Supplemental Material published in EHP articles may not conform to 508 standards due to the complexity of the information being presented. If you need assistance accessing journal content, please contact [email protected]. Our staff will work with you to assess and meet your accessibility needs within 3 working days.